ライフサイエンスコーパス: hedgehog

1 DNA methylation profiles of infantile sonic hedgehog-activated medulloblastoma (SHH-INF) were subdiv

2 tion-impaired salivary function by transient Hedgehog activation and are promising therapeutic target

3 g and qRT-PCR of sorted cells indicated that Hedgehog activation greatly enhances paracrine interacti

4 ring fibrotic repair, Gli1(+) MSCs integrate hedgehog activation signalling to upregulate BMP antagon

5 ly rare long after irradiation and transient Hedgehog activation.

6 idly impaired by irradiation and restored by Hedgehog activation.

7 g irradiation but were restored by transient Hedgehog activation.

8 tion-impaired salivary function by transient Hedgehog activation.

9 We find that Hedgehog acts through Bmp to delineate the position of t

10 We propose that the inactivation of PTCH1 by Hedgehog allows a transmembrane sterol to access this se

11 nd MAPK3 involved in the WNT, TGF-beta, JNK, HedgeHog and ERK1/2 pathways suggests the regulation of

12 groups, indicating they resemble human Sonic hedgehog and group 3 and 4 medulloblastoma and CNS neuro

13 nt of therapeutics targeting the Notch, WNT, Hedgehog and Hippo pathways.

14 stasis and function, such as the Notch, WNT, Hedgehog and Hippo signalling cascades, continues to be

15 t to the RPE expresses high levels of Indian Hedgehog and identified its downstream target as stromal

16 ol of self-renewing progenitors involves the hedgehog and mammalian target of rapamycin complex 1 (mT

17 models and tissues, the relationship between Hedgehog and polycystic kidney disease is not known.

18 Anti-inflammatory cascades, namely Wnt, Hedgehog and PPAR pathways, were downregulated.

19 other developmental pathways (e.g. the Wnt, Hedgehog and TGFbeta pathways), Hippo signalling is a 'j

20 se disease were identified in genes encoding Hedgehog and Wnt signaling pathway molecules, which are

21 novo variants were identified in SHH (Sonic Hedgehog), and inherited variants were identified in HSP

22 umors revealed inhibition of the RAS-GTPase, Hedgehog, and Notch pathways, along with evidence of act

23 Hedgehog binds the transmembrane protein Patched, which

24 GLI2, SOX11, or GPC4, which function in the Hedgehog, BMP, and Wnt signaling pathways; other genes i

25 icing sequences in eukaryotes, including the Hedgehog C terminus.

26 Deletion of the obligate Hedgehog co-receptor, Smoothened, in Sox9-expressing cel

27 ry disease, while endothelial-derived desert hedgehog (DHH) is expressed at the BBB under resting con

28 ally restricted platform for localization of Hedgehog effectors at the cilium tip.

29 The correct localization of Hedgehog effectors to the tip of primary cilia is critic

30 Posterior transplantation of Hedgehog-expressing cells induced mirror-image limb dupl

31 Furthermore, GC treatment reduced Indian Hedgehog expression in growth plates of wild-type mice b

32 the enhancer-driven activation of the Sonic hedgehog gene (Shh), we have identified a change in chro

33 Salivary gland cells responsive to Hedgehog/Gli signaling comprised small subsets of macrop

34 cord and telencephalon via the regulation of Hedgehog/Gli signaling.

35 A Hedgehog (Hh) antagonist, vismodegib, was found to suppr

36 Hedgehog (Hh) autoprocessing converts Hh precursor prote

37 The Hedgehog (Hh) family of morphogens direct cell fate deci

38 Hedgehog (Hh) is an evolutionarily conserved signaling p

39 In vertebrate embryos, Hedgehog (Hh) is expressed in some anterior basal plate

40 The Hedgehog (Hh) pathway controls embryonic development and

41 The Hedgehog (HH) pathway controls multiple aspects of crani

42 Basal cell carcinomas (BCCs) rely on Hedgehog (HH) pathway growth signal amplification by the

43 The Hedgehog (Hh) pathway is essential for embryonic develop

44 The evolutionarily conserved hedgehog (Hh) pathway is essential for organogenesis and

45 We identifed frequent Hedgehog (Hh) pathway mutations in BSCs, implicating Hh

46 The hedgehog (HH) pathway, first discovered and elucidated i

47 The canonical Hedgehog (HH) pathway, for example, is a bona fide cilia

48 tion factor GLI1, a terminal effector of the Hedgehog (Hh) pathway, is required for the repair of rDN

49 Here we show that Wdp modulates the Hedgehog (Hh) pathway.

50 ignaling pathways, including elements of the Hedgehog (Hh) pathway.

51 with predisposing mutations in the Nodal and Hedgehog (HH) pathways, with penetrance and expressivity

52 Extracellular Hedgehog (Hh) proteins induce transcriptional changes in

53 ntracellular responses and are essential for Hedgehog (Hh) signal transduction in mammals.

54 ll differentiation and proliferation require Hedgehog (HH) signaling and aberrant HH signaling causes

55 Hedgehog (Hh) signaling can mediate both processes.

56 kers - type II collagen, sox9, aggrecan, and hedgehog (Hh) signaling components, including Gli1 and P

57 Here, we reveal that activation of Hedgehog (Hh) signaling in adjacent epithelial and strom

58 Ligand-dependent activation of Hedgehog (Hh) signaling in cancer occurs without mutatio

59 on of proliferation is a primary function of Hedgehog (Hh) signaling in development.

60 nscription activator (RTA) activity and host hedgehog (hh) signaling in LXA4-treated KSHV-infected ce

61 several murine tumor models, we showed that hedgehog (Hh) signaling in myeloid cells is critical for

62 echanistically, NCC cilia ablation abolishes hedgehog (Hh) signaling in the periocular mesenchyme (PO

63 Hedgehog (Hh) signaling is crucial for establishing comp

64 In particular, ITZ inhibits the hedgehog (Hh) signaling pathway and has the potential to

65 Activation of the Hedgehog (Hh) signaling pathway by mutations within its

66 The Hedgehog (Hh) signaling pathway is crucial for vertebrat

67 forebrain defects.SIGNIFICANCE STATEMENT The Hedgehog (Hh) signaling pathway is essential for proper

68 The hedgehog (Hh) signaling pathway plays several diverse re

69 in embryonic development are governed by the Hedgehog (Hh) signaling pathway, an evolutionary conserv

70 many tumorigenic events associated with the hedgehog (hh) signaling pathway.

71 Since hedgehog (Hh) signaling regulates cancer cell proliferat

72 Here, we report that NRF2 suppresses hedgehog (Hh) signaling through Patched 1 (PTCH1) and pr

73 veals transcriptional expression of GLI1, of Hedgehog (Hh) signaling, in poor-risk MDS/AML.

74 Next, we demonstrate that hedgehog (Hh) signaling, which has been implicated in th

75 ing proteins that putatively are involved in hedgehog (Hh) signaling.

76 KIF14 as a regulator of cilia formation and Hedgehog (HH) signaling.

77 bolism and a key developmental regulator-the Hedgehog (Hh) signalling pathway.

78 hereas ventral neural fates are specified by Hedgehog (Hh) signalling.

79 gate complex patterning defects and define a Hedgehog (Hh)-fibroblast growth factor (FGF) signaling a

80 Mutations in key signaling pathways such as Hedgehog (HH)/Gli can disrupt tracheoesophageal (TE) mor

81 Basal cell carcinomas (BCCs) depend on Hedgehog (Hh)/Gli signaling, but can develop mechanisms

82 velopmental pathways such as TAZ, Notch, and hedgehog; how clearance of dead cells in NASH via effero

83 ivated T cells 1 (Nfatc1), Runx3, and Indian hedgehog (Ihh) signaling pathways, although the mechanis

84 nalyses revealed that the promoter of Indian Hedgehog (IHH), a canonical driver of normal colonocyte

85 In Drosophila, Interference hedgehog (Ihog) or its close paralogue Brother of Ihog (

86 cer stemness is also reversed upon CXCR4 and hedgehog inhibition.

87 ination with a CXCR4 antagonist (AMD3100) or hedgehog inhibitor (GDC-0449) displays reduced tumor gro

88 When loaded with the hedgehog inhibitor vismodegib, the cRGDyK-guided liposom

89 Hedgehog interacting protein (Hhip) is essential for isl

90 hitherto uncharacterized gene called HHIPL1 (hedgehog interacting protein-like 1), which encodes a se

91 Finally, using the GLI1-regulated gene HHIP (Hedgehog-interacting protein) as a model, we demonstrate

92 In cuttlefish limb buds, Hedgehog is expressed anteriorly.

93 ifferent kinetics, through distinct modes of Hedgehog ligand reception.

94 The secreted Hedgehog ligand Sonic Hedgehog (SHH) binds to its recept

95 In the absence of Hedgehog ligand, patched-1 (Ptch1) localizes to cilia an

96 Unlike the native Hedgehog ligand, this nanobody does not require lipid mo

97 Hedgehog ligands increase cholesterol accessibility in t

98 thened abundance and elevated sensitivity to Hedgehog ligands.

99 ich induces unconventional Weyl nodes with a hedgehog-like radial spin texture near the conduction ba

100 ents with the medulloblastoma subgroup Sonic Hedgehog (MB(SHH))(.) ELP1 was the most common medullobl

101 We have utilized a natural lipidation PTM (hedgehog-mediated cholesterol modification of proteins)

102 s were exclusively associated with the sonic hedgehog medulloblastoma (MB(SHH)) subgroup and accounte

103 The Sonic Hedgehog medulloblastoma subgroup transcriptionally mirr

104 tial adhesion code is regulated by the sonic hedgehog morphogen gradient.

105 FGF and Hedgehog morphogen signals are required, with FGF provid

106 letal myogenic lineage through modulation of Hedgehog, Notch, and bone morphogenetic protein (BMP) si

107 ant signaling pathways like EGF/EGFR and Wnt/Hedgehog/Notch.

108 Intriguingly, the palmitate anchor of Hedgehog occupies a similar site in the homologous tunne

109 ependent signaling to the overall effects of Hedgehog on cellular physiology appears to be much large

110 Sonic Hedgehog-overexpressing tumors express PTCH-induced cell

111 ne expression data suggested that the Indian Hedgehog-parathyroid hormone-related protein signaling a

112 Our findings suggest that inhibiting Hedgehog-Patched interaction could result in more effect

113 onstrated dose-dependent inhibition of sonic hedgehog-patched-gli signaling.

114 ctivity, facilitating mechanistic studies of Hedgehog pathway activation and the engineering of pathw

115 ent adenylyl cyclase signaling represses the Hedgehog pathway and promotes morphogenetic patterning.

116 Misactivation of the Hedgehog pathway can cause developmental abnormalities a

117 Suppression of Hedgehog pathway either by CRISPR mediated SHH knock out

118 ates the transcriptional events of the sonic hedgehog pathway genes that are implicated in almost one

119 et genes and, importantly, downregulation of hedgehog pathway genes.

120 , translational, and clinical studies of the Hedgehog pathway have helped reveal how cells communicat

121 neither downregulation nor activation of the Hedgehog pathway in epithelial cells along the nephron s

122 This nanobody potently activates the Hedgehog pathway in vitro and in vivo by stabilizing an

123 Vismodegib is a hedgehog pathway inhibitor indicated for the treatment o

124 Cyclopamine, a hedgehog pathway inhibitor, significantly decreased the

125 The Hedgehog pathway is critical for the development of dive

126 Activation of the Hedgehog pathway may have therapeutic value for improved

127 1 transcription factor must maintain maximal Hedgehog pathway output in basal cell carcinomas (BCCs),

128 degib, the cRGDyK-guided liposomes inhibited hedgehog pathway signaling specifically in activated HSC

129 xpression through the mediation of Gli1, the Hedgehog pathway transcription factor.

130 es the ubiquitination and degradation of the Hedgehog pathway transducer Smoothened.

131 y2 knockout is completely independent of the Hedgehog pathway transducer Smoothened.

132 re, we identify Ankmy2 as a repressor of the Hedgehog pathway via adenylyl cyclase targeting.

133 ycin to target CD33, glasdegib to target the hedgehog pathway, and a liposomal formulation of daunoru

134 This extends to the Hedgehog pathway, which primarily serves to counter GLI

135 of these six genes enhanced activity of the hedgehog pathway.

136 sterol transport at two crucial steps in the Hedgehog pathway.

137 C-X-C motif chemokine receptor 4 (CXCR4) and hedgehog pathways cooperate in PC chemoresistance via bi

138 th targeted inhibition of both the CXCR4 and hedgehog pathways improves outcomes in a PC mouse model.

139 is abrogated by inhibition of the CXCR4 and hedgehog pathways.

140 ting to wnt/beta-catenin, TGF-beta and sonic hedgehog pathways.

141 ase D], APOE [apolipoprotein E], IHH [Indian hedgehog protein], ITIH4 [inter-alpha-trypsin inhibitor

142 Hedgehog proteins are pivotal morphogens acting through

143 Hedgehog proteins bind to and inhibit the transmembrane

144 a conformation-specific nanobody against the Hedgehog receptor Patched1 (PTCH1).

145 nitor markers, comparable to the loss of the Hedgehog receptor Patched1.

146 landscape of adult RPE/choroid and uncover a Hedgehog-regulated choroidal immunomodulatory signaling

147 e aging, and that it does so by regulating a Hedgehog-related signaling factor, WRT-10.

148 l patterning and maturation include the Wnt, Hedgehog, retinoic acid, and Hippo signaling pathways.

149 lls and interneurons via the amount of sonic hedgehog secreted.

150 Furthermore, we provide evidence that Sonic hedgehog (Shh) activates Gli2 by stimulating its phospho

151 Here, we investigated how Sonic hedgehog (Shh) and Fibroblast growth factor (Fgf) signal

152 ntral nervous system, CNS), depends on Sonic hedgehog (SHH) as a main signaling morphogen.

153 nstitute the core reception system for sonic hedgehog (SHH) as well as GLI transcription factors, the

154 HS production around the lesion allows Sonic hedgehog (Shh) binding and favors the local enrichment o

155 The secreted Hedgehog ligand Sonic Hedgehog (SHH) binds to its receptor Patched1 (PTCH1) in

156 e found that on induction of mouse AD, Sonic Hedgehog (Shh) expression in skin, and Hh pathway action

157 In Ftm (-/-) embryos, Sonic hedgehog (Shh) expression was virtually lost in the vent

158 gion were observed including decreased Sonic hedgehog (Shh) expression, abnormal cell adhesion, and a

159 All tumor samples clustered within the sonic hedgehog (SHH) group.

160 nd histone modification, is induced by Sonic Hedgehog (SHH) in SHH-dependent cerebellar progenitor ce

161 We showed that gigaxonin governs Sonic Hedgehog (Shh) induction, the developmental pathway patt

162 Sonic hedgehog (Shh) is a multifunctional signaling protein go

163 Hepatic expression of Sonic Hedgehog (SHH) is associated with Non-alcoholic fatty li

164 The signaling protein Sonic Hedgehog (SHH) is crucial for the development and functi

165 and cancer: it covalently modifies the Sonic hedgehog (SHH) ligand, restricting its release from prod

166 Sonic Hedgehog (SHH) medulloblastomas are brain tumours that a

167 ental hierarchy of progenitor pools in Sonic Hedgehog (SHH) medulloblastomas, and identified OLIG2-ex

168 nuclear RNAs (snRNAs) in about 50% of Sonic hedgehog (SHH) medulloblastomas.

169 lt in transcriptomic activation of the Sonic Hedgehog (SHH) pathway in SSTs.

170 The Sonic Hedgehog (SHH) pathway plays a key role in cancer.

171 on; and RGS5, decay of which activates Sonic Hedgehog (SHH) pathway-mediated differentiation of matur

172 Here, we present a system to trigger a Sonic Hedgehog (SHH) protein gradient in developing forebrain

173 nt carrying a germline mutation in the sonic hedgehog (SHH) receptor PTCH1.

174 Sonic hedgehog (Shh) signal transduction specifies ventral cel

175 ain tumor treatment, but inhibition of Sonic Hedgehog (SHH) signaling has failed in SHH-driven medull

176 Here, we show that Sonic hedgehog (Shh) signaling in mature astrocytes is require

177 In the healthy, adult CNS, Sonic hedgehog (Shh) signaling is active in mature, differenti

178 Although sonic hedgehog (SHH) signaling is known to activate CGNP proli

179 In the developing cerebellum, Sonic hedgehog (SHH) signaling is required for expansion of ce

180 h changes in genes associated with the sonic hedgehog (SHH) signaling pathway, required for spatial p

181 e driven by aberrant activation of the Sonic Hedgehog (SHH) signaling pathway.

182 Mutations in Sonic hedgehog (SHH) signaling promote aberrant proliferation

183 Reduced sonic hedgehog (SHH) signaling was confirmed by in situ hybrid

184 PBO was recently found to inhibit Sonic hedgehog (Shh) signaling, a key developmental regulatory

185 e neuron precursors (CGNPs) induced by Sonic Hedgehog (SHH) signaling, but downstream effectors of mi

186 In Sonic hedgehog (SHH) signaling, GLI family zinc finger (GLI)-m

187 Driven by pathogenic activation of sonic hedgehog (SHH) signaling, SHH subgroup MB (SHH-MB) accou

188 n of apical constriction controlled by Sonic hedgehog (Shh) signaling.

189 he underlying pathogenic mechanisms on Sonic Hedgehog (Shh) signaling.

190 rotein coupled receptor that regulates Sonic Hedgehog (Shh) signaling.

191 local temporospatial requirements for sonic hedgehog (SHH) signalling during tongue development.

192 Here, we show that Sonic hedgehog (Shh) signalling in the embryonic chick wing bu

193 s studies found that astrocyte-derived Sonic hedgehog (SHH) stabilizes the BBB during CNS inflammator

194 In Sonic Hedgehog (SHH) subgroup medulloblastoma, aberrant activa

195 al. (2018) describe genetic models of Sonic Hedgehog (SHH) subgroup of medulloblastoma with SUFU alt

196 Using a transgenic mouse model for the sonic hedgehog (Shh) subgroup of medulloblastoma, here we eval

197 ), which are abundantly present in the Sonic Hedgehog (SHH) subgroup of medulloblastoma.

198 ing development, HFSC progeny secretes Sonic Hedgehog (SHH) to direct the formation of this APM-sympa

199 shes the growth stimulation effects of sonic hedgehog (SHH) treatment, resulting in the disruption of

200 We also found that tumor cells secrete sonic hedgehog (SHH), an Hh ligand, and that tumor-derived SHH

201 ellular localization, interaction with sonic hedgehog (SHH), and influence on hedgehog signaling were

202 groups of MB have been described (WNT, sonic hedgehog (SHH), Group 3 and Group 4), each of which is a

203 The activating ligand, Sonic hedgehog (SHH), is highly hydrophobic because of dual pa

204 ed largely of netrin1 (FP-netrin1) and Sonic hedgehog (Shh), that can attract the axons at a distance

205 ation of fibroblasts was identified as sonic hedgehog (Shh), which was rapidly induced in renal tubul

206 sforming growth factor-beta (Tgfbeta), sonic hedgehog (Shh), wingless-integrated site (Wnt)/beta-cate

207 evolution at single-cell resolution in sonic hedgehog (SHH)-activated medulloblastomas that originate

208 be a cell cycle timer that operates in Sonic hedgehog (Shh)-expressing polarising region cells of the

209 Here we generate humanized models for Sonic Hedgehog (SHH)-subgroup MB via MYCN overexpression in pr

210 d N-terminal signaling domain of human Sonic hedgehog (ShhN(p)) at a 4:2 stoichiometric ratio.

211 viously we proposed that transmission of the hedgehog signal across the plasma membrane by Smoothened

212 the Frizzled-class (class-F), transduces the Hedgehog signal from the tumour suppressor Patched-1 (PT

213 tudy identifies the existence of a divergent Hedgehog signal pathway mediated by Ptch2 and provides a

214 Our work provides molecular insights into Hedgehog signal transduction and the activation of a cla

215 Trapping this accessible cholesterol blocks Hedgehog signal transmission across the membrane.

216 rotein that interacts with SHH and increases hedgehog signaling activity.

217 ed for phenotypic analysis and assessment of hedgehog signaling activity.

218 Further studies indicate that hedgehog signaling acts through the Foxf1/2 transcriptio

219 Knockout embryos have increased Hedgehog signaling and completely open neural tubes show

220 We present mouse models of sonic hedgehog signaling and craniofacial malformations to ill

221 EGF-C strongly correlates with activation of Hedgehog signaling and EMT in the human disease.

222 Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced b

223 ecreted proatherogenic protein that enhances hedgehog signaling and regulates smooth muscle cell prol

224 sutures with a consequent imbalance in MAPK, Hedgehog signaling and RUNX2 expression.

225 This TGF-beta-CREB-Hedgehog signaling axis allows a key metabolic tissue to

226 e that activation of canonical Gli-dependent Hedgehog signaling by Gli1 gene transfer is sufficient t

227 hanism to control Smo's ciliary level during Hedgehog signaling by regulating the ubiquitination stat

228 Pkd1 combined with conditional modulation of Hedgehog signaling components in renal epithelial cells,

229 Activation of Hedgehog signaling decreases Smo ubiquitination and cili

230 esults indicate that Dsg2 enhances canonical hedgehog signaling downstream of Ptc1 to promote BCC dev

231 ors that specifically regulate regeneration (hedgehog signaling effector gli-1) or maintenance (RREB2

232 Hedgehog signaling governs critical processes in embryog

233 ugh recent studies have found alterations in Hedgehog signaling in ADPKD-related models and tissues,

234 After increasing or decreasing levels of Hedgehog signaling in cells that underwent inactivation

235 (WT) motor function for cilium assembly and Hedgehog signaling in Kif3a/Kif3b double-knockout cells.

236 Tissue-specific inactivation of hedgehog signaling in neural crest-derived mandibular me

237 tected in the affected individuals inhibited hedgehog signaling in NIH 3T3 fibroblasts, thereby provi

238 xamine the potential role of cell-autonomous Hedgehog signaling in regulating kidney cyst formation i

239 nd biochemically to regulate the strength of Hedgehog signaling in target cells.

240 In vivo genetic impairment of Hedgehog signaling induced significant loss of choroidal

241 Sonic Hedgehog signaling is critical for breast morphogenesis

242 In contrast to its role in development, Hedgehog signaling is dispensable for the proliferative

243 echanisms favoring SP cells and suggest that Hedgehog signaling may provide a viable target for ovari

244 the transcriptionally independent effects of Hedgehog signaling on cytoskeleton.

245 In addition, the expression of Hedgehog signaling pathway components Shh, Gli1, and Pat

246 s a new class of glycosides that inhibit the hedgehog signaling pathway through a nonsmoothened mode

247 tion as cholesterol transport systems in the Hedgehog signaling pathway, driven by either sodium or p

248 s disorders may result from dysregulation of hedgehog signaling pathways.

249 Loss of hedgehog signaling reduced expression of Osr1 and PMC-sp

250 Noncanonical Hedgehog signaling remains poorly characterized but is t

251 tudies indicate that transient activation of Hedgehog signaling rescues irradiation-impaired salivary

252 e-tethered ubiquitin complex that attenuates Hedgehog signaling strength and genetically interact to

253 set of stromal cells characterized by active hedgehog signaling that proliferate, acquire a myofibrob

254 L1 knockdown aortic smooth muscle cells, and hedgehog signaling was decreased in HHIPL1-deficient cel

255 Host hedgehog signaling was modulated in an AMP-activated pro

256 with sonic hedgehog (SHH), and influence on hedgehog signaling were tested.

257 ere they showed that transient activation of Hedgehog signaling within the murine submandibular gland

258 Cholesterol plays two critical roles in Hedgehog signaling, a fundamental pathway in animal deve

259 function, as indicated by dysregulated sonic hedgehog signaling, abnormal staining for IFT-B componen

260 -mesenchymal transition and up-regulation of hedgehog signaling, and consequently biliary tree inflam

261 iliary entry of membrane-associated protein, Hedgehog signaling, and embryogenesis.

262 m2-null MEF show normal ciliary dynamics and Hedgehog signaling, but additional loss of a Thm1 allele

263 er-frequency variants, Kruppel-like factors, Hedgehog signaling, Hippo-YAP signaling, long noncoding

264 rns, we identified genes involved in WNT and Hedgehog signaling, neurogenesis, and axonal guidance as

265 , including genes that are markers of active hedgehog signaling, Osr1 (encodes a transcription factor

266 l-derived meninges, while variants affecting Hedgehog signaling, PI3K signaling, TRAF7, KLF4, and POL

267 s, facilitates ciliogenesis and alters Sonic Hedgehog signaling, pointing to a key role in cytoskelet

268 These results define an essential step in Hedgehog signaling, whereby coreceptors activate SHH by

269 phogenetic anomalies resulting from impaired hedgehog signaling, which is transduced by primary cilia

270 architecture, protein trafficking and Sonic hedgehog signaling.

271 te wingless/Int-1 signaling and SMO mediates Hedgehog signaling.

272 or developmental pathways, including Wnt and hedgehog signaling.

273 Both modes appear to be independent of hedgehog signaling.

274 questers cholesterol in complexes, amplifies Hedgehog signaling.

275 codes a sequence homolog of an antagonist of hedgehog signaling.

276 ulted in shortened cilia and defective sonic hedgehog signaling.

277 erol transporter, in germ cell migration and Hedgehog signaling.

278 e approach to inhibit SMO function and thus, Hedgehog signaling.

279 Smoothened (SMO) is a GPCR that mediates hedgehog signaling.

280 The Hedgehog-signaling pathway is an important target in can

281 se findings show that Gli1(+) MSCs integrate hedgehog signalling as a rheostat to control BMP activat

282 atelet-derived growth factor (PDGF), WNT and hedgehog signalling drive disease progression in later s

283 al myogenesis, which is instead initiated by Hedgehog signalling from the notochord.

284 an endogenous ligand of PTCH1, can stimulate Hedgehog signalling in cells and can trigger G-protein s

285 mechanism for differential interpretation of Hedgehog signalling in the germ cell niche.

286 Moreover, Ptch2-mediated Hedgehog signalling induces the phosphorylation of Creb

287 Hedgehog signalling is fundamental to embryonic developm

288 Aberrant postnatal Hedgehog signalling leads to several malignancies, inclu

289 ) transcription factors, which activates the Hedgehog signalling pathway(1,2).

290 c/Cdon act as co-receptors in the vertebrate Hedgehog signalling pathway, but the nature of their int

291 of Boc and Gas1 may determine the outcome of Hedgehog signalling through compartmentalisation and mod

292 between WNT, bone morphogenetic protein and hedgehog signalling with SFRP1.

293 ue anomalies seen in patients with disrupted hedgehog signalling.

294 ) can promote tumor progression in the sonic hedgehog subgroup of medulloblastoma (SHH-MB).

295 The sonic hedgehog subtype of medulloblastoma (SHH MB) is associat

296 in PDGF, EGFR, VEGF, insulin/IGF/MAPKK, FGF, Hedgehog, TGFbeta, and PI3K signaling pathways.

297 in tumor with five molecular subtypes, Sonic Hedgehog TP53-mutant, Sonic Hedgehog TP53-wildtype, WNT,

298 subtypes, Sonic Hedgehog TP53-mutant, Sonic Hedgehog TP53-wildtype, WNT, Group 3, and Group 4, defin

299 o show a retrograde transport defect for the Hedgehog transducer, Smoothened, and an impaired respons

300 After establishment by sonic hedgehog, ventral NSC identity became independent of thi