ライフサイエンスコーパス: heighten

1 y, the need to understand glucose metabolism heightens.

2 se, and in older patients the Ab titers were heightened.

3 rapid expansion of this strain was due to a heightened ability to evade host immune responses during

4 Thus, memory CD8 T cells with heightened ability to recognize environmental inflammato

5 uration of neuronal connectivity may explain heightened abuse liability in individuals with a history

6 cans may protect them from T-cell expansion, heightened activation of interferon pathways, and diseas

7 ubgenual cingulate, which is associated with heightened activity and negative affect in depression.

8 ted into local excitatory circuitry and have heightened activity compared to adulthood.

9 S boosted excessive 'wanting' of rewards and heightened activity in the anterior medial prefrontal co

10 and implicate cytokine-mediated effects and heightened adaptive immune responses.

11 Heightened aggression can be serious concerns for the in

12 linical interventions.SIGNIFICANCE STATEMENT Heightened aggression can have devastating social conseq

13 Heightened aggression is characteristic of multiple neur

14 and that these neuroadaptations mediate the heightened alcohol drinking and anxiety-like behavior ob

15 ndicate that chronic hypoxia reduces EDD via heightened alpha-adrenergic signaling in lowlanders and

16 d later cardiovascular ischemic risk that is heightened among patients with post-procedure MALE hospi

17 h post-traumatic stress disorder (PTSD) show heightened amygdala activity; elevated levels of stress

18 Heightened amygdala reactivity (particularly to negative

19 Heightened amygdala response to threatening cues has bee

20 The threat of nuclear exposure is heightened and it is imperative to identify potential co

21 nt, compensation, and incentive-and identify heightened and novel ethical concerns in the context of

22 thway, resulting in metabolic dysregulation, heightened angiogenesis, intratumoral heterogeneity, and

23 Preferential dendrite growth allows for heightened animal responses to sensory stimuli, indicati

24 Rationale: Individuals with asthma have heightened antibody responses to rhinoviruses (RVs), alt

25 Heightened anxiety-like behavior was also observed in wi

26 Furthermore, all 3 lineages caused heightened apoptosis and reduced organoid size.

27 d from the basal forebrain during periods of heightened arousal directly excites somatostatin (SST)-e

28 nditioning, pupil and EEG markers related to heightened arousal were identified.

29 e auditory cortex of awake mice to show that heightened arousal, as indexed by pupil diameter, broade

30 ing creates an optimal exposure condition by heightening attention and awareness of present moment se

31 The beneficial effects of heightened autophagy from Becn1(F121A) was abolished by

32 ls, we hypothesized that water warming would heighten average individual aggression.

33 hat disrupted output of iMSNs contributes to heightened avoidance behavior.

34 of iMSN output with optogenetic stimulation heightened avoidance of open areas of these tasks, while

35 on worldwide public health and economies has heightened awareness about the lack of effective antivir

36 These results call for heightened awareness and further studies mainly regardin

37 The #MeToo movement heightened awareness of sexism in science.

38 ive vitreoretinopathy in patients with RP, a heightened awareness of this condition is critical in fa

39 Despite quality improvement programs and heightened awareness, sepsis accounts for greater than 5

40 ments in AHNPC phenotypes and suppresses the heightened baseline anxiety observed in mice expressing

41 neural circuit refinement during windows of heightened brain plasticity, but little is known about t

42 and 2) do so through mechanisms selectively heightened by sadness.

43 hotspots and that their impact on sensing is heightened by the CNT network's proximity to percolation

44 ose patients to PML, a goal whose urgency is heightened by the lack of anti-JCPyV agents.

45 This is further heightened by the limited availability of natural betala

46 cting their enhanced basal STIM1-binding and heightened Ca(2+)-dependent inactivation.

47 ce of low-density granulocytes (LDGs) with a heightened capacity for spontaneous NETosis, but the con

48 e that a subset of T cell clones possesses a heightened capacity to form TRM, and that enriched expre

49 C) from LysM (Cre) :Ppard (fl/fl) mice had a heightened capacity to prime myelin oligodendrocyte glyc

50 e of origin on subsequent reactivation and a heightened capacity to redifferentiate into T(RM) cells.

51 Transiently heightened cardiovascular risk around the 2016 election

52 nces triggered incipient atherosclerosis and heightened cardiovascular risk in the SIV-infected HFD-r

53 scular disease has long been associated with heightened cardiovascular risk, much is still unknown re

54 hat depletion of HOIP or Sharpin resulted in heightened caspase-1 activation and cell death in respon

55 he addition of gammadelta T cells results in heightened CD4(+) T cell activation.

56 phrine levels in the spleen, indicating that heightened, central sTNFalpha signaling drives periphera

57 , including persistently enhanced memory and heightened cFos in the basolateral amygdala complex (BLC

58 ributed to enhanced callose accumulation and heightened CLA resistance.

59 Heightened clinical suspicion, improved diagnostic imagi

60 Hundreds of millions of people face heightened coastal risk across Africa, Eurasia, and the

61 ome endow human brains with the capacity for heightened cognitive abilities?

62 s of marine mammal populations worldwide and heightened concern about their impacts on marine food we

63 d suggested that this is driven by liberals' heightened concern with social equality.

64 evolutionary importance of paternal care and heightened cooperation to human life history, human fath

65 We confirmed adult females exhibit a heightened corticosterone response when in SA photoperio

66 We found significantly heightened defense and reduced approach responses to thr

67 Both lesion groups showed heightened defensive and reduced approach responses, acc

68 Moreover, pyramidal neurons in A25 had a heightened density of NMDARs, which are the targets of n

69 dies that suggest that BI is associated with heightened detection of novelty or threat.

70 navirus disease 2019 (COVID-19) pandemic has heightened discussion of the use of mobile phone data in

71 AM before infection, which may contribute to heightened disease severity.

72 Studies of previous pandemics demonstrate heightened distress in health care workers years after t

73 y transplant recipients with C-/SC-TCMR have heightened early allograft chronicity and worse renal fu

74 ict both increased negative emotion risk and heightened EDA, consistent with the proposed allostatic

75 sex disparities in prescribing should prompt heightened efforts to improve the standard and equity of

76 l genes Tead2, Spred1, and Nav3 demonstrates heightened EGFRvIII-glioma cell proliferation.

77 e cingulate cortex, respectively, suggesting heightened empathic proclivities and abilities for fear.

78 The suPAR-treated HK-2 cells showed heightened energetic demand and mitochondrial superoxide

79 f our study region, we identified an area of heightened energetic risk in the northwestern part of th

80 Heightened error monitoring in adolescence moderated hig

81 tive sensory neurons and contribute to their heightened excitability.SIGNIFICANCE STATEMENT Somatosen

82 levated rates of protein synthesis driven by heightened expression of ABCE1, a vulnerability that can

83 dLN of LdCen(-/-) -immunized mice exhibited heightened expression of costimulatory molecules and att

84 to regenerate, with wound edge cells showing heightened expression of structural genes and prominent

85 coculture with gammadelta T cells results in heightened expression of the costimulatory molecule CD86

86 ificantly larger in vacuoles with engineered heightened expression of the H(+)-PPase.

87 that HIV gene expression is associated with heightened expression of transcriptional pathways associ

88 a previously established task used to reveal heightened fall rates in DL rats, to broadly test the ro

89 Heightened fear and inefficient safety learning are key

90 b-5p, and proteins associated with PTSD-like heightened fear expression.

91 ts that greater temperatures and drought may heighten florivory in perennials.

92 ceptibility to psychopathology have led to a heightened focus on both typical and atypical trajectori

93 ransiently activates male odr-10 expression, heightening food sensitivity and reducing food leaving.

94 The difference in these outcomes was heightened for those aged >=75 years compared with those

95 We also identified an endocrine profile of heightened GLP-1 and PP but lower ghrelin that different

96 rmogenic-like BAT phenotype is not linked to heightened glucose tolerance in female mice.

97 type 1 receptor (TNFR1) plays a key role in heightened glutamate signaling in the hypothalamic parav

98 peptidoglycan synthesis and remodeling with heightened granularity.

99 In particular, melatonin heightened GSH content as well as the ratio of GSH/GSSG

100 obesity/diabetes, hyperinsulinemia maintains heightened hepatic expression of cyclin D1, suggesting a

101 1 activation contributes to hypertension via heightened hypothalamic glutamate-dependent signaling.SI

102 asymptomatic heterozygous carriers released heightened IL-1beta specifically in response to Y. pesti

103 lpha degradation, sustained cRel activation, heightened IL-2 production and T cell expansion.

104 increased; sensitivity to D-amphetamine was heightened; immobility times decreased on the tail suspe

105 mmals, such as humans and wild mice, display heightened immune activation compared with artificially

106 There is heightened immune dysfunction and tumor progression but

107 In general, heightened immune responses limit pathogen-induced cellu

108 eases such as cancer that can be combated by heightened immune surveillance.

109 gulated 10 genes, including several encoding heightened immune-function or antimicrobial activities.

110 terized by strong response to interferon and heightened immunomodulatory properties.

111 velopment of type 2 diabetes, indicating the heightened importance of body weight control in these pa

112 This meta-analysis indicates heightened impulsivity across a range of cognitive domai

113 Heightened impulsivity in youth was significantly and sp

114 lymphopoietin expression, which were further heightened in chronic lesions.

115 virus 1 (HIV-1) infection is associated with heightened inflammation and excess risk of cardiovascula

116 Heightened inflammation in the male VAT facilitated the

117 etween atrophy and insulin signalling during heightened inflammation is believed to be possible.

118 esent evidence that aging is associated with heightened inflammation, impaired SPM:LT ratio, defectiv

119 especially in the setting of HIV viremia and heightened inflammation.

120 ntiviral state, but if unchecked can lead to heightened inflammation.

121 cterized by chronic bacterial infections and heightened inflammation.

122 obial translocation and memory NK cells with heightened inflammatory potential, and explains the chro

123 The heightened inflammatory response detected in BAL fluid f

124 oximal and distal TE cell population's shows heightened inflammatory signaling in distal differentiat

125 fy and inhibit pathways that perpetuate this heightened inflammatory state because this could lead to

126 A heightened inflammatory state is associated with major a

127 T-cell manufacturing feasibility as well as heightened inflammatory toxicities, leading to dose de-e

128 isms by which fatty acids lead to a state of heightened innate immunity and inflammation.

129 isms by which fatty acids lead to a state of heightened innate immunity and inflammation.

130 nique metabolic profile that correlates with heightened insulin sensitivity and GLP-1 secretion.

131 a, intracranial pressure (ICP) is attracting heightened interest because of its influence on optic ne

132 ell-specific Nlrp12-deficient mice display a heightened interferon and TNF response and are more resi

133 NMR and alanine mutagenesis suggest a heightened involvement of the C-terminal alpha-helix of

134 ated in certain interferonopathies, in which heightened IRF3 activity leads to IFN-beta-induced disea

135 While H2A.Z widens the barrier, uH2B heightens it, and both modifications greatly lengthen Po

136 s lose cell membrane association, leading to heightened KRAS activity.

137 evated after widowhood when distress is at a heightened level.

138 Cystic fibrosis (CF) patients experience heightened levels of anxiety and depression.

139 ty toward compatible P. syringae and possess heightened levels of markers of lipid peroxidation after

140 Predominantly fueled by heightened local proliferation, tissue macrophage number

141 et, and streptozotocin-induced diabetes) had heightened lung ACE2 and TMPRSS2 protein levels and incr

142 4)Cu-Macrin in rabbits and pigs, we detected heightened macrophage numbers in the infarcted myocardiu

143 tory increase in the number of monocytes and heightened macrophage-dependent inflammation in the kidn

144 that myeloid-CITED2 deficiency significantly heightened macrophages and neutrophils recruitment to th

145 ogressed to mild cognitive impairment (MCI), heightened memory awareness was observed up to 1.6 years

146 This heightened metabolism results in elevated levels of reac

147 ptor 2 (HER2) expression, is associated with heightened metastatic potential and poor prognosis.

148 Furthermore, heightened miR-223 expression in KLF6-deficient macropha

149 itigate oxidative stress in response to this heightened mitochondrial activity.

150 re to high altitude (HA) is characterized by heightened muscle sympathetic neural activity (MSNA); ho

151 within the normal range were associated with heightened near-term risk for death, acute MI, or hospit

152 By contrast, in response to heightened neuronal activity, ARNT2 recruits the neurona

153 139WfsX2 mutation, we show a reversal of the heightened neuronal excitability, linking the phenotype

154 r stroke showing that early injury responses heighten neuroplastic potential, to date, visual rehabil

155 ion was essential for NMDA signaling and the heightening NMDA currents during hypertension.

156 Conditional RIM1 KO mice show heightened novelty-induced locomotion and impaired motor

157 This reveals a heightening of the barrier to unfolding in G37R by >5 kJ

158 ge of geologic formations has simultaneously heightened oil and gas production, brought extractive ac

159 occur in virtually all cancers and result in heightened oncogenic E2F activity, leading to uncontroll

160 Similarly, AM-heightened opsonophagocytic capacity was correlated with

161 develop an abnormal response to pain, either heightened or diminished.

162 ubchondral bone sclerosis has been linked to heightened osteogenic commitment of bone marrow stromal

163 Other discovered IgGs heighten pain indirectly by T-cell-mediated inflammation

164 eurons and Schwann cells (SCs) may result in heightened pain processing and chronic pain states.

165 ever, the molecular mechanisms that underlie heightened pain processing remain incompletely understoo

166 -day Britons, where they are associated with heightened pain sensitivity.

167 chanism through which viral infections cause heightened pain sensitivity.

168 Defensive system activation promotes heightened perception of threat signals, and excessive a

169 eading to elevated filling pressures through heightened pericardial restraint.

170 n developing mouse cortex coincides with the heightened period of synaptogenesis, but is precipitousl

171 Clinical studies suggest that heightened peripheral inflammation contributes to the pa

172 A subset of melanomas display heightened peroxisome proliferator-activated receptor ga

173 idence of metabolic reprogramming as well as heightened phagocytosis and increased expression of the

174 ce live longer than WT littermates, and have heightened phosphaturia from downregulation of two key N

175 -b-PLA and PEG-b-PCL nano-assemblies display heightened plasma exposure, reduction in biodistribution

176 plantation into mouse V1 creates a window of heightened plasticity that is quantitatively and qualita

177 ual variation of the troposphere, tropopause heightening, position and speed of atmospheric interface

178 tion over that of Treg cells, and promoted a heightened pro-inflammatory gene expression signature.

179 ion (MI) triggers myelopoiesis, resulting in heightened production of neutrophils.

180 Stimulated trained macrophages showed heightened production of reactive oxygen and nitrogen sp

181 r Pag1(-/-) recipients demonstrated that the heightened propensity for T(H) 2-cell differentiation wa

182 Tumor mitochondria have heightened protein folding quality control, but the regu

183 Despite the potent ability of N-MYC in heightening protein synthesis and malignant characterist

184 verlooked features of these datasets such as heightened reactivity patterns in the signal recognition

185 e for deficits in Pavlovian processes (e.g., heightened reactivity to safety cues in anxious samples)

186 , alters cortisol dynamics during stress and heightens reactivity to proximal and distal threat.

187 nts caused enhanced callose accumulation and heightened resistance to CLA, suggesting that the OPDA-m

188 to enhanced callose deposition by providing heightened resistance to CLA.

189 selected in Mediterranean populations confer heightened resistance to Y. pestis.

190 yers (repetition suppression) coupled with a heightened response in the deep layers (repetition enhan

191 lier encounters that in turn facilitates the heightened response of these cells, as well as that of t

192 , which has been hypothesized to result from heightened response to information of high spatial frequ

193 ude the ability of fish macrophages to mount heightened responses to a secondary stimulus in a nonspe

194 also be generated by vaccination, exhibiting heightened responses to cytokine stimulation months afte

195 the hypothesis that FND is characterised by heightened responsiveness to verbal suggestion.

196 Area 14 overactivation was found to induce heightened responsivity to uncertain, low-imminence thre

197 prolonged immunomodulatory therapies have a heightened risk for developing PML.

198 degrees of retinopathy appearing to carry a heightened risk for each outcome.

199 In light of the heightened risk for infection associated with solid orga

200 with peripheral artery disease (PAD) are at heightened risk for ischemic events related to atherothr

201 patients and their friends and relatives at heightened risk for long-term opioid use, misuse, overdo

202 ation, a pathway that may link stress with a heightened risk for many diseases.

203 scence and emerging adulthood are periods of heightened risk for psychopathology associated with emot

204 ratio [IRR], 2.2; 95% CI, 1.3-3.5), with the heightened risk limited to the postpartum period (IRR, 5

205 FLG and likely EDC variants in terms of the heightened risk of AD, but foremost enables to predict e

206 in identifying relatives with high Lp(a) and heightened risk of ASCVD, particularly when the proband

207 st-FEP stabilization may be characterized by heightened risk of behavioral disinhibition and violence

208 with peripheral artery disease (PAD) are at heightened risk of cardiovascular complications.

209 K2-related Parkinson disease patients have a heightened risk of certain nonskin cancers, including br

210 Non-index readmission carries a heightened risk of FTR.

211 of developing such a vaccine among those at heightened risk of infection, controlled human infection

212 undwater to freshwater ecosystems may pose a heightened risk to endobenthic organisms (buried in sedi

213 howed no clear inflection point or period of heightened risk.

214 atization of certain sectors of society, and heightened risks and unequal treatment of individuals du

215 between in utero exposure to smoking and the heightened risks for the subsequent development of neuro

216 the advent of agriculture imposed radically heightened selective pressures in agriculturalist popula

217 stibular and visual stimuli characterized by heightened self-motion sensitivity and visually-induced

218 They further show heightened self-paced instrumental responding for food a

219 ly mammalian embryos to transition away from heightened self-renewal and toward competency for lineag

220 rough context-specific enhancer activity and heightened sensitivity of the lower jaw to Sox9 expressi

221 Consistently, NEK10-deficient cells display heightened sensitivity to DNA-damaging agents.

222 ith impulse control disorders also exhibited heightened sensitivity to exogenous monetary rewards cue

223 sposal during negative selection and confers heightened sensitivity to experimental autoimmune enceph

224 posed to chronic antigen stimulation exhibit heightened sensitivity to IL-6, which contributes to the

225 Individuals with heightened sensitivity to punishment (SP) are especially

226 Anxious individuals exhibit heightened sensitivity towards chemosensory stress signa

227 sistance to chemotherapy, but simultaneously heightens sensitivity to immune checkpoint blockade in a

228 Users report heightened sexual pleasure as a motivation for further d

229 ter anxiety in social situations also showed heightened sharpened tuning of visuocortical neurons to

230 dications are proposed explanations for this heightened skin cancer risk; however, the exact mechanis

231 reat learning, pathological anxiety involves heightened skin conductance response to potential but no

232 Heightened somatic symptoms are reported by a wide range

233 owed correlation between low 5-HT levels and heightened somatic symptoms.

234 metabolic) hearing loss etiology may explain heightened speech perception difficulties in people over

235 vanilla or H(2)O mice, PL layers 2/3 showed heightened spontaneous excitatory post-synaptic currents

236 eurons with useful functional coding exhibit heightened stability to support memory guided behavior.

237 heir utility, splitter neurons would exhibit heightened stability.

238 epending on whether DAergic activity is in a heightened state and if there is a functional CLOCK prot

239 ified a historically unprecedented period of heightened storm activity common to four Florida panhand

240 Heightened stress exposure was defined as exposure to at

241 of the TMPRSS6 gene that is hypothesized to heighten susceptibility to IL-6-mediated inflammatory ef

242 Heightened susceptibility to peer influence and hypersen

243 gs into adolescence or identified periods of heightened susceptibility.

244 RT deficiency enhances pulmonary fibrosis by heightening susceptibility to bleomycin-induced epitheli

245 rcuits below the injury results in abnormal, heightened sympathetic responses, such as extreme, sudde

246 anders, upward baroreflex resetting promotes heightened sympathetic vasoconstrictor activity and main

247 pose tissue, an important SIV reservoir, and heightened systemic immune activation and inflammation,

248 Although several reports have documented heightened systemic inflammation in posttraumatic stress

249 order (PTSD) has increasingly been linked to heightened systemic inflammation.

250 .23 s-1 vs 1.39 +/- 0.27 s-1; P = .003), and heightened systemic monocyte activation.

251 y, nitric oxide production may contribute to heightened systemic sNVT and provide a potential neurova

252 d study with 400 participants suggested that heightened systemizing underlies this relationship.

253 her than qualitative, with chronic AD having heightened T(H)2, T(H)1, T(H)17, and IL36 responses and

254 nd absences by -0.5 to +3.6 days/test but at heightened testing needs of 989.6-1995.9 tests/1000 work

255 enotype in LysM (Cre) :Ppard (fl/fl) mice to heightened Th responses.

256 oading dual ligands we postulated to achieve heightened Th-1 immune response that would yield pronoun

257 This situation is thought to heighten the overall inflammatory state via increased ba

258 s population and increased interconnectivity heighten the risk that infectious diseases pose for huma

259 Conversely, smoking heightened the inflammatory response evident by change i

260 In addition, long-term activation of DRD2 heightened the sphere-forming capacity of GBM cells, as

261 injustice and colonial legacies, which have heightened the vulnerability of human and other biotic c

262 ased over successive generations, while also heightening the rate of host genome selection.

263 deposition, impairing vascular exchange and heightening the risk of advanced fibrosis.

264 ects and very high compositional homogeneity heightens the likelihood that Cd(0.9)Zn(0.1)Te(0.98)Se(0

265 The global decline of coral reefs heightens the need to understand how corals respond to c

266 be how studying increasingly complex samples heightens the relevance of single-molecule results to in

267 improving others' well-being also comprises heightening their positive affect or decreasing their ne

268 expenditure is highest during REM because of heightened theta and gamma activity.

269 ocampal structure and function contribute to heightened threat appraisal at the time of trauma vs. su

270 ay pose a reduced pandemic risk but remain a heightened threat for poultry.IMPORTANCE Avian influenza

271 Heightened threats for nuclear terrorism using improvise

272 BACKGROUNDGiven the heightened tolerance to self-starvation in anorexia nerv

273 s that decrease PIEZO2 function could reduce heightened touch responses during inflammation.

274 ncides with improved nucleosome positioning, heightened transcription factor binding, and increased e

275 , chromosome missegregation also resulted in heightened transformation potential, assessed by colony

276 d to intrusive re-experiencing of trauma via heightened trauma memory.

277 t of the immune and endocrine systems and/or heightened tumour predisposition.

278 ation and memory differentiation, suggesting heightened turnover.

279 lung morphogenetic processes associated with heightened Type 2 immunity are not merely a tissue "back

280 e other linking enhanced threat learning and heightened uncertainty estimation to symptoms of depress

281 Improving coral reef conservation requires heightened understanding of the mechanisms by which cora

282 dies reveal that the loss of PIGBOS leads to heightened UPR and increased cell death.

283 led to proliferation of intestinal cells and heightened V. parahaemolyticus' colonization and virulen

284 e updates for attended stimuli, resulting in heightened value estimates.

285 difference in the speed prior, but there was heightened variability in the ASD group.

286 However, despite heightened variation among CTE neurons, CTE cases exhibi

287 fter stroke and demonstrate that a window of heightened vascular plasticity is coupled to the reestab

288 d that stroke created a restricted period of heightened vascular plasticity that was associated with

289 e impaired vasodilator capacity is involved, heightened vasoconstrictor tone and/or responsiveness ma

290 a unique phenotype of HFpEF characterized by heightened ventricular interaction, right heart failure,

291 Although heightened vessel leakiness has been linked to glial and

292 e increase in striatal ACh relative to DA is heightened via D1-type DA receptors that activate ChIs i

293 C4-deficient mice exhibit heightened viral burdens.

294 different subtypes and genotypes, exhibited heightened virulence in mammals, and extended their host

295 tural power of business interests lends them heightened visibility in policy debates.

296 Among the factors that confer heightened vulnerability are the substantial energy requ

297 ype during a period of rapid lung growth and heightened vulnerability.

298 are reduced when practicing compassion, and heightened when being self-critical.

299 Continued and heightened wild amphibian disease surveillance is a prio

300 ed fertility, and increasing stresses due to heightened workload and greater mobility required for ca