ライフサイエンスコーパス: helical

1 it a novel type IV pilin fold that is purely helical.

2 the type of chirality, namely, axial versus helical.

3 s comprised of unstructured Abeta(M1-42) and helical 4F.

4 lar circular dichroism relative to a smaller helical analogue, even though they share a similar struc

5 RNA triple helix is more similar to both the helical and base step structural parameters of A'-RNA ra

6 The C-terminal portion of M13 becomes alpha-helical and develops contacts with the N-terminal domain

7 The emphasis of this review is on helical anion foldamers in solution, and many of the bea

8 otoprogrammable chiro-optical mesogenic soft helical architectures.

9 crease of the electronic polarization of the helical architectures.

10 he bipartite zona pellucida (ZP) module in a helical arrangement with a rise of ~65 angstrom and a tw

11 Type IV filaments (T4F), which are helical assemblies of type IV pilins, constitute a super

12 on the surface of bacteria, consisting of a helical assembly of pilin proteins.

13 -MVB12A was determined, revealing an ESCRT-I helical assembly with a 12-molecule repeat.

14 al positioning of the sticky ends around the helical axis is less clear.

15 the absorptivity of these molecules as their helical axis lengthens.

16 The computed subtalar joint helical axis parameters showed consistency across all he

17 Some translation along the helical axis was also observed, reflecting the elasticit

18 uantum chemical calculations reveal that the helical backbone in these molecules offers not only thro

19 -fold increase in the local bending of DNA's helical backbone without evidence of DNA wrapping around

20 nt of nucleic acids, alteration in the alpha-helical/beta-sheet protein ratio, structural changes in

21 d molecular orbital (HOMO) in both axial and helical bicarbazole monoradicals along with a subtle dif

22 radical in comparison with monocarbazole and helical bicarbazole ones.

23 her-resolution cryo-EM of filaments bound to helical bicelles confirms that ESCRT-III filaments can i

24 oreover, nanoparticles constructed with such helical bodipy show efficient PDT-mediated antitumor imm

25 at can adopt two very different homotrimeric helical bundle conformations-one short (~66 angstrom hei

26 onstrate this we first modified the designed helical bundle hemoprotein H4, creating a highly charged

27 ted a red copper protein site within a three helical bundle scaffold which we later revisited and det

28 re-hairpin intermediate to its post-fusion 6-helical bundle state.

29 gather behind the cell body and form a close helical bundle, which propels the cell forward during a

30 Strikingly, alpha-helical bundles formed from the extended C-termini of ca

31 Domain swapping in the alpha-helical C-terminal domain of M(pro) (M(pro)C) locks M(pr

32 predicted structure revealed a unique alpha-helical C-terminal region which we demonstrated to be es

33 lysis of all residues of the (extracellular) helical cap of THIK-1 showed that mutation of the argini

34 conformation which is regulated by an alpha-helical capping "switch" at the loop between the A and B

35 us, a versatile organic photoredox catalyst (helical carbenium ion) for red-light-mediated photoredox

36 Helical cell shape is necessary for efficient stomach co

37 The helical centerline pitch and radius of wild-type H. pylo

38 l structure with two geometrically different helical channels in a 2:1 ratio with the same handedness

39 We suggest that dynamics in the two helical classes are dominated by distinctly different mo

40 HA, most notably a 150 angstrom-long triple-helical coil of HA2, which may bridge between the viral

41 ization pathway, leading to the formation of helical coiled-coil htt(ex1) tetramers, is completely ab

42 red 2D/3D structures such as serpentines and helical coils of conventional materials.

43 ased circular dichroism to confirm its alpha-helical conformation and transmembrane alignment.

44 transitions of extracellular loop 2 from the helical conformation in the D(2)R/risperidone structure

45 subcomplex shows that ARP binding induces a helical conformation in the helicase-SANT-associated (HS

46 The arrested NC adopts a compact alpha-helical conformation that induces 28 S rRNA nucleotide r

47 , our data indicates that S4 undergoes alpha-helical conformation to a short-lived different secondar

48 zing that portion of the S4 segment in alpha-helical conformation).

49 ly forms an imperfect polyproline (polyP) II helical conformation.

50 which we reveal adopts a predominantly alpha-helical conformation.

51 ferent G-patch proteins, transiently samples helical conformations, possibly facilitating a conformat

52 and i, i + 7 pairs, to favor 3(10)- or alpha-helical conformations, respectively.

53 carbons populate regular and less-controlled helical conformations, respectively.

54 lded, with exchange between beta strands and helical conformations.

55 orbance spectrum and injects a charge into a helical conjugated pai-system without injecting a spin.

56 nalysis showed a solvent-dependent degree of helical content in the structural ensembles when adding

57 We found that when a large amount of helical content was present early in a transition path,

58 ompositions of folded ensembles with varying helical content.

59 Implementation of these helical copper precatalysts in the hydrosilylation of 1-

60 s poorly understood how the difference in TM helical crossing angles found in the two conformations i

61 aize RS3 because the former possessed double-helical crystallites of a more compact structure.

62 Interleukin-2 (IL-2) is a small alpha-helical cytokine that regulates immune cell homeostasis

63 tions with the adjacent triplexes as well as helical density attributed to the pUL17 and pUL25 subuni

64 version of 1 resulted instead in a dinuclear helical dimer, [((tBu)pyrr(2)py)Fe](2) (3), via bridging

65 bromide-based layers cause symmetry-breaking helical distortions in the inorganic layers, otherwise a

66 We explain these findings by modeling double-helical DNA as a twisted wormlike chain with a finite wi

67 The transfer of charges through double helical DNA is a very well investigated bioelectric phen

68 e guide RNA displaces one strand of a double-helical DNA substrate, positioning the DNase active site

69 hereas Delta-cis has a preference for double-helical DNA.

70 s, Ddi1 and its homologs contain a conserved helical domain (helical domain of Ddi1, HDD) and a retro

71 The ASCC3 fragment comprises a central helical domain and terminal, extended arms that clasp th

72 presence or absence of an unassembled triple-helical domain is not the key feature driving cellular r

73 auto-inhibited conformation in which the XPF helical domain masks the ERCC1 (HhH)(2) domain and restr

74 h as mouse Fringe reveals a novel N-terminal helical domain of B3GNTs that may stabilize the catalyti

75 homologs contain a conserved helical domain (helical domain of Ddi1, HDD) and a retroviral-like prote

76 The C-terminal helical domain of EspG(3mm) is dynamic, alternating betw

77 t extended high-mannose glycosylation at the helical domain of transferrin receptor protein 1 promote

78 Ts OLD lacks the C-terminal helical domain present in Class 2 OLD homologs yet prese

79 troscopy (PET-FCS) to show how a small alpha-helical domain, the N-terminal domain of HemK, folds cot

80 o the association of well-characterized TnT1 helical domains and either isolated tropomyosin or actin

81 ed by recognizing stalled assembly of triple-helical domains or by direct engagement of the C-Pro its

82 e its CIP (Ctf4-interacting peptide)-binding helical domains remain available to recruit partner prot

83 scillations of highly mobile two dimensional helical electrons propagating on a conducting surface of

84 es increase of the reciprocal velocity of 2D helical electrons: [Formula: see text] suggesting modifi

85 inding of a weakly base-paired [UUUU]:[GGAG] helical element.

86 resolution revealed that 5D5 binds an alpha-helical epitope in N-CSP with high affinity through exte

87 zed by cytosolic plant-conserved regions and helical exchange within the transmembrane segments, form

88 structure reveals that FlhB/SctU extends the helical export gate with its four predicted transmembran

89 ues (G335 and G338) are potent inhibitors of helical extension and helix-helix interaction, which are

90 epends on binding-site strand, position, DNA helical face and chromatin context.

91 The 3D helical fibers can be readily integrated with fabrics an

92 -AO molecules self-assemble into left-handed helical fibers with cross-sectional diameters of about 1

93 nusual structure of ComGC is compatible with helical filament assembly.

94 gers transition from flat spiral polymers to helical filament to drive the formation of membrane prot

95 by the RecA family of ATPases, which form a helical filament with single-stranded DNA (ssDNA) and AT

96 P1B first polymerizes into a single-stranded helical filament, shaping membranes into moderate-curvat

97 onsisting of a torque-generating motor and a helical filament, which acts as a propeller.

98 y in physiological conditions to form paired helical filament-like fibres in vitro in the absence of

99 that all Tau isoform fibrils exhibit paired-helical-filament-like structures consisting of two proto

100 opy confirmed that ESCRT-I subcomplexes form helical filaments in solution.

101 from the assembly of two distinct bundles of helical filaments that have the same helical path but bi

102 ropel and change direction by rotating long, helical filaments, called flagella.

103 Most motile bacteria are propelled by rigid, helical, flagellar filaments and display distinct swimmi

104 cell, driving the ion-driven rotation of the helical flagellum.

105 ain of NPR4 refolded with SA adopts an alpha-helical fold that completely buries SA in its hydrophobi

106 ps adopt the unique aquaporin-like hourglass helical fold.

107 eir strands are capable of adopting a triple-helical fold.

108 Novel unprecedented helical foldamers have been effectively designed and syn

109 assified into proteins with 2/2 or 3/3 alpha-helical folding around the heme cavity.

110 TM proteins and identification of stable two-helical folding intermediates.

111 ance (HSQC NMR) spectroscopy revealed robust helical folding propensity in acetonitrile.

112 ily accessible monomer diversity and peptoid helical folding propensity.

113 ests that LPL is condensed into its inactive helical form for storage in intracellular vesicles.

114 or HBV, DHBV CLPs consist of a dimeric alpha-helical frame-work with protruding spikes at the dimer i

115 ation between the ATP-binding pocket and the helical gate.

116 The protein deviates from the ideal alpha-helical geometry due to three phenylalanine residues, wh

117 he gamma-TuRC arranges gamma-tubulins into a helical geometry poised to nucleate microtubules.

118 , our data allows discerning details such as helical grooves, single-strand versus double-strand cros

119 de-branching, in particular resulting in the helical growth of microstructure in a chessboard strateg

120 ) gain-of-function mutations in the flexible helical hairpin domain HP2 and applied linear free energ

121 The domain 3a helical hairpin of Vps45 is unfurled, exposing the presu

122 We show that Pf3 is inserted as a helical hairpin, i.e., the prospective transmembrane seg

123 Here, using a helical-hairpin construct derived from CFTR's transmembr

124 Ph SAM forms helical head to tail polymers, and SAM-SAM interactions

125 e molecular weight of 18.2 kDa and 3.6 nm in helical height, exhibits the highest anion-transport act

126 The most potent helical heterogeneous 1:1 alpha/Sulfono-gamma-AA peptide

127 The use of helical hexapeptides to establish a surface dipole layer

128 core complex shows Periphilin forms an alpha-helical homodimer, bound by a single TASOR molecule.

129 This knowledge will guide the design of helical hydrocarbons as rigid scaffolds or as hydrophobi

130 Alpha-helical integral membrane proteins contain conserved seq

131 The ability to modulate helical integrity by pH may enable incorporation of exte

132 Mutation of VPS28 helical interface residues blocks filament formation in

133 solution and the solid state through double-helical intermolecular and transannular hydrogen bonding

134 orted protein family 1 (EPF1) and Plasmodium Helical Interspersed Sub-Telomeric (PHIST) gene families

135 e use of self-assembled monolayers (SAMs) of helical lanthanide-binding peptides.

136 P2-membrane interactions, in addition to the helical lid domain.

137 pled peptides are a class of bioactive alpha-helical ligands developed to target protein-protein inte

138 agneto-optical Kerr effect(1,2), spontaneous helical light emission(3,4) from ferromagnetic (FM) mono

139 (N2) and third (N3) NEAT domains joined by a helical linker, called IsdH(N2N3).

140 Mutation of one of the helical LPL interaction interfaces causes loss of the fi

141 s required for the formation of multilayered helical M1 oligomers similar to those observed in virion

142 Such photoprogrammable mesogenic soft helical materials are competitive candidates for use in

143 n of the mechanism for a simple prototype of helical membrane protein folding.

144 This tool can be applied to diverse alpha-helical membrane proteins, and may aid in the developmen

145 stabilising variants of [Formula: see text]-helical membrane proteins, increasing efficiency and red

146 tion is a fundamental step in the folding of helical membrane proteins.

147 that promote raft partitioning for multispan helical membrane proteins.

148 Cryo-ET reveals how the shape of the helical membrane tube arises from the assembly of two di

149 an ideal molecular scaffold to design alpha-helical mimetics.

150 ent modes--pseudo-one-dimensional, localized helical modes in one case, and pseudo-three-dimensional

151 f freedom has an unbounded set of orthogonal helical modes that could function as information channel

152 n of aryl substituents at position 23 of the helical moieties has a negligible impact on the optical

153 nding and unbinding events between the alpha-helical molecular recognition element (alpha-MoRE) of th

154 ity-induced spin selectivity (CISS), whereby helical molecules polarize the spin of electrical curren

155 sordered region with and without a transient helical motif and one disordered protein containing a re

156 rce field capable of retaining the transient helical motif observed in NMR experiments.

157 ologous actin-binding proteins use conserved helical motifs to associate with the vinculin head domai

158 stabilizer of MEILB2 by binding to an alpha-helical N-terminus of MEILB2 and preventing MEILB2 self-

159 the major achievements in the development of helical nanomaterials are highlighted.

160 he synthesis of a new perylene-diimide-based helical nanoribbon, which exhibits the largest molar ele

161 These shape-persistent helical nanoribbons incorporate multiple helicenes, a cl

162 The helical nature of the topological polaritons, where pola

163 Helical NP superstructures are a rapidly expanding subcl

164 e presence of Ca(2+) revealed that NS2 forms helical oligomers which, when aligned with the N-termina

165 However, single-layered helical oligomers with biochemical and ultrastructural s

166 , we report an observation of incommensurate helical ordering of electric dipoles by light hole dopin

167 eals that Eag chaperones mimic transmembrane helical packing to stabilize effector TMDs.

168 dles of helical filaments that have the same helical path but bind the membrane with different interf

169 swim faster than 500 um.s(-1) along a double helical path, making them one of the fastest natural mic

170 igned capping peptides control the length of helical peptide nanofibers with unique precision.

171 secretase complex that contain an N-terminal helical peptide region that engages a substrate docking

172 connection with similar behavior as one long helical peptide with a kink.

173 ation and characterization of a set of alpha-helical peptides and stapled derivatives that specifical

174 Moreover, we demonstrate that two helical peptides can form a kink-like connection with si

175 city originating from self-assembly of alpha-helical peptides is incomplete.

176 ces of a set of perfluoroarene stapled alpha-helical peptides of the BIM BH3 peptide to the BCL(XL) r

177 In particular, the proline/glycine kink in helical peptides was reported to both increase and decre

178 mino acids in the construction of stabilized helical peptides.

179 ides represent a new generation of unnatural helical peptidomimetics, which have similar folding conf

180 ly help achieve more conformationally stable helical peptoids with desired functions.

181 kunloop) of DNA with sticky ends over three helical periods (100-130 bp) using single-molecule fluor

182 bre modes, cylindrical vector (CV) beams and helical phase front optical vortex (OV) beams.

183 orbital photogalvanic effect, driven by the helical phase gradient, is distinguished by a current wi

184 ode purity up to 99%, and (b) control of the helical phasefront from 2pai-6pai and the revolving spee

185 e-Gaussian ([Formula: see text]) beam with a helical phasefront rotating around its own beam center.

186 of Janus-faced building blocks to establish helical pillars as well as lateral branches that togethe

187 Up to 3000 copies of FimA assemble to the helical pilus rod through a mechanism termed donor stran

188 ouble helices with programmed handedness and helical pitches.

189 Topological helical polaritons provide a platform for developing rob

190 At the population level, they included a helical population-trajectory geometry with shifts in th

191 tructures of the water-soluble forms of a 12-helical pore and a 16-helical pore closely match the com

192 -soluble forms of a 12-helical pore and a 16-helical pore closely match the computational design mode

193 h those reported for the transmembrane alpha-helical portion of the amyloid precursor protein after t

194 protein nanomachine and comprises a rotating helical propeller attached to a membrane-embedded motor

195 l flagella are ultimately constructed from a helical propeller that is attached to a motor embedded i

196 he H2 region of C. thermophilum IC has a low helical propensity and establishes that H2 binds directl

197 helices consistent with winding/unwinding in helical propensity as the knot tightens to secure the SA

198 Further, we show that the helical propensity of the H1 NTD is subtype-dependent an

199 red protein containing a region of increased helical propensity).

200 o C11, exhibit a dramatic odd-even effect in helical propensity.

201 of temperature sensing; ELF4, a small alpha-helical protein; and LUX ARRYTHMO (LUX), a DNA-binding p

202 nd post-translational translocation of alpha-helical proteins across inner membrane and the assembly

203 It is further shown that helical proteins fall into two classes with very differe

204 tivity, generates cationic amphipathic alpha-helical proteoforms.

205 tive site and displacing RNA, while a unique helical protrusion inserts into the main channel, prying

206 f BurrH, an 82-kDa DNA-binding protein whose helical pseudosymmetry prevents accurate image orientati

207 cence while also inducing the formation of a helical PTAA-LL37(FRRV) construct, as confirmed by circu

208 atory role of a third structurally conserved helical region (HR3) in F.

209 study, we uncovered a novel role of a third helical region (HR3) of the NiV fusion glycoprotein in t

210 Therefore, the TDP-43 helical region serves as a short but uniquely tunable mo

211 aM N and C domains bind independently to two helical regions at the GRK5 N and C termini to inhibit G

212 This unprecedented structural plasticity of helical repeats may be a general regulatory mechanism of

213 rand RNA viruses relies on two components: a helical ribonucleocapsid and an RNA-dependent RNA polyme

214 g creates the exceptional stiffness of these helical rods, with a persistence length of more than 200

215 ents in the membrane, which are converted to helical rotations in the catalytic core via an interveni

216 Highly charged, single alpha-helical (SAH) domains contain a high percentage of Arg,

217 The dynamic domain is anchored to the helical scaffold by a secondary hydrophobic core, pinnin

218 Herein, we use an alpha-helical scaffold to control the iron coordination geomet

219 create de novo metalloproteins within alpha-helical scaffolds.

220 single chain contains alternating zigzag and helical sections.

221 the pore-lining helix, which contains a pai-helical segment in the closed and open conformations, bu

222 smembrane segment, followed by a short alpha-helical segment, a large unstructured loop, and finally,

223 tarts vectorially as soon as the first alpha-helical segments are synthesized.

224 As nascent chain grows, emerging helical segments dock onto each other and continue to re

225 n impaired conformational adaptability of TM helical segments in CFTR.

226 are deformed into sequential arrays of half-helical segments of alternating handedness (perversions)

227 Furthermore, C(H)2 helical segments, beta-sheets, beta-turns, and random co

228 small fraction of chiral monomer units, the helical sense of a dynamic polymer constructed from achi

229 Furthermore, the helical sense of chirality can be controlled by varying

230 re the fast side-chain dynamics of the alpha-helical sensory rhodopsin II and the beta-barrel outer m

231 with altered polymerization properties lose helical shape and associated positive Gaussian curvature

232 onditions tested, in contrast with the usual helical shape of other members of the family Spirochaeta

233 but the molecular mechanisms for generating helical shape remain unclear.

234 The 3D helical shape results from stress relaxation of the pres

235 e chiro-optical properties of such mesogenic helical soft materials by homogeneously dispersing photo

236 xamer in which five spastin subunits adopt a helical, spiral staircase configuration that binds the p

237 rmal base G while they are nested in the DNA helical stack.

238 e unique because they exhibit three distinct helical states, two of which are triggered by coassembli

239 upramolecular polymer that features multiple helical states.

240 ring geometry, stacking interactions, double-helical stems, and G-quadruplexes are immediately obviou

241 organic frameworks(12-14) that feature rigid helical strands interlaced in all three dimensions, rath

242 en the peptide planes without assuming alpha-helical structure a priori.

243 mplex indicated that E2A-AD1 adopts an alpha-helical structure and uses its PhiXXPhiPhi motif to bind

244 resulting peptide, mast-MO, adopted an alpha-helical structure as determined by NMR, exhibited increa

245 bicity and particle size increased and alpha helical structure decreased, reducing the stability of s

246 lpha-helix in the prodomain N terminus adopt helical structure in a membrane-mimetic environment.

247 otation, inducing twisting that results in a helical structure of defined chirality.

248 The double-helical structure of DNA results from canonical base pai

249 The double-helical structure of genomic DNA is both elegant and fun

250 e synthesis results in the alteration of DNA helical structure or reduced thermal stabilities.

251 Thus, DcuS contains a long alpha-helical structure reaching from the sensory PAS(P) (alph

252 of a peptide that abrogates the formation of helical structure resulted in poor loading efficiency.

253 g domain in hRpn10 locks into a well-defined helical structure to form an intermolecular 4-helix bund

254 ral region of the Nterm domain adopted alpha-helical structure upon titration of Nterm and Nterm-ACB

255 ntigenic peptides from random coils to alpha-helical structure, is important for antigen loading insi

256 the Q/H segments adopt minor populations of helical structure, show decreased mobility and start to

257 characterized by a seven-transmembrane alpha-helical structure, transmitting extracellular signals in

258 w that dynamin bundles actin while forming a helical structure.

259 D spectral shifts consistent with an induced helical structure.

260 idine, thus becoming an integral part of the helical structure.

261 TDP-43 assembly and function via modulating helical structure.

262 Helical structures are ubiquitous in natural and synthet

263 ng shape, yet a general principle to realize helical structures at the sub-100 nm scale via colloidal

264 The one-dimensional helical structures presented in this study are unique be

265 Well-defined helical structures that have been identified in several

266 recent studies suggest the (co)existence of helical structures, albeit in racemic form.

267 mputational simulations suggested that these helical sulfono-gamma-AA peptides could mimic the critic

268 nfers reversible handedness inversion to the helical superstructure upon irradiation with visible lig

269 ics, which promotes the formation of elegant helical superstructures or supramolecular assemblies in

270 Such helical superstructures play key roles in the propagatio

271 al molecular switches induce photoresponsive helical superstructures, that is, cholesteric liquid cry

272 a rigid [6]helicene-based core within their helical superstructures.

273 theoretical studies of the self-assembly of helical supramolecular polymers of (S)-triarylamine tris

274 The hinge angle can diverge further from helical symmetry at the microtubule seam, generating a s

275 ons of the m-loop that are incompatible with helical symmetry.

276 The helical tail structure of Fab C10:DENV3 clubSP showed al

277 antiomeric l- and d-blocks (FKFEFRFD) formed helical tapes closely resembling those of the heterochir

278 otifs with opposite chirality, assemble into helical tapes with dimensions greatly exceeding those of

279 ere employed to quantitatively show that the helical tetraspan peripheral myelin protein 22 (PMP22) e

280 ed as single- or multistrand complexes-often helical-that incorporate one or more anions.

281 eltaG(asc) in 554 PDB structures of 85 seven-helical TM proteins and identification of stable two-hel

282 an endogenous substrate resembling an alpha-helical TM.

283 We demonstrate helical topological polaritons up to 200 kelvin without

284 ith N-aminoazetidine-2-carboxylic acid, an 8-helical topology is shown to dominate for sequences up t

285 erate is the only possibility to enable both helical tracks and fast reorientations.

286 re, and a subset of folded motors lie on the helical tracks described previously.

287 el opening is accompanied by an alpha-to-pai helical transition in the pore-lining transmembrane heli

288 Nevertheless, some multispan helical transmembrane proteins have been proposed to par

289 ring functions has yielded a consensus alpha-helical transmembrane structure for Pf1 protein.

290 ed monomer at low concentrations to an alpha-helical trimer at high concentrations.

291 clear oscillation with a period close to the helical turn of DNA (~10.5 bp).

292 ites with a periodicity corresponding to one helical turn of DNA, spanning ~40 bases and centered ~80

293 four strand antiparallel beta-sheet and two helical turns stabilized by a complex disulfide bond net

294 ogen exchange rates extending as far as +/-2 helical turns, pointing to a substantial degree of coope

295 Due to helical unwinding, the RNA triple helix spans an average

296 en conformations, but becomes entirely alpha-helical upon inactivation.

297 region were determined and found to be alpha-helical using nuclear magnetic resonance (NMR) spectrosc

298 the sequence identity at corresponding polar helical-wheel heptad sites between vaccine and nonvaccin

299 The oncogenic spacer region is alpha-helical, which contrasts with previous suggestions that

300 However, the chain is helical, with only one enantiomer present, resulting in