ライフサイエンスコーパス: helical structure

1 ds stabilize a very different dimeric, alpha-helical structure.

2 1-4 are able to self-assemble into this beta-helical structure.

3 beta-turn structures at the expense of alpha-helical structure.

4 w that dynamin bundles actin while forming a helical structure.

5 ed with multiple domains and increased alpha-helical structure.

6 D spectral shifts consistent with an induced helical structure.

7 t resides in their ability to adopt an alpha-helical structure.

8 ble oligomers that retain their native alpha-helical structure.

9 idine, thus becoming an integral part of the helical structure.

10 talyze the hydrolysis of the collagen triple-helical structure.

11 The N terminus of NaKtide adapts a helical structure.

12 revealed that it folded in to a kinked alpha-helical structure.

13 interactions; and (3) non, disfavoring alpha-helical structure.

14 ulting in over half of the RD adopting alpha-helical structure.

15 TDP-43 assembly and function via modulating helical structure.

16 ons of BID remain solvent-exposed and retain helical structure.

17 minantly as a tetramer that is rich in alpha-helical structure.

18 ic functional groups at the periphery of the helical structure.

19 bilising tertiary interactions or persistent helical structure.

20 intermediate suggest that it may be a triple helical structure.

21 ions of DNA rather than to its native double helical structure.

22 tions at the G98 site that may perturb alpha-helical structure.

23 quence-related variations encoded within the helical structure.

24 direction of their effects reflecting alpha-helical structure.

25 on to form a coiled-coil or other interchain helical structure.

26 ngth of ~50 nm, driven by its elegant double helical structure.

27 des containing this sequence, inducing alpha-helical structure.

28 fications to create a membrane-spanning beta-helical structure.

29 a disordered regime and only little residual helical structure.

30 e, consecutive nucleobase pairs might impact helical structure.

31 ors, and the polypeptides regain their alpha-helical structure.

32 compound to adopt a unique right-handed 311 helical structure.

33 SP-Fab311 complex forming a highly organized helical structure.

34 proteins (OMPs), including those with alpha-helical structure.

35 forms from disordered (random coil) to alpha helical structure.

36 d from sites of local deformation in the RNA helical structure.

37 the accommodation of the pendants within the helical structure.

38 r preferences, and stabilizes the C-terminal helical structure.

39 y members can potentially integrate into the helical structure.

40 is found to form both right- and left-handed helical structures.

41 ciations composed of regular, enantiomorphic helical structures.

42 son-Crick H-bonds are fully paired in double-helical structures.

43 other terpene synthases having highly alpha-helical structures.

44 pattern associated with the formation of 2.5-helical structures.

45 hierarchy of more or less compact irregular helical structures.

46 require the formation of beta-sheet or alpha-helical structures.

47 tent of the cis isomer responsible for their helical structures.

48 eement with rotamers previously reported for helical structures.

49 '-5' exonucleases by highly conserved triple helical structures.

50 system can be fulfilled by several competing helical structures.

51 acid sequence associated with straight alpha-helical structures.

52 en the peptide planes without assuming alpha-helical structure a priori.

53 CT constructs identified one region of alpha-helical structure (A333-N361) that mediates CT dimerizat

54 on, the peptides adopt mainly either a alpha-helical structure able to permeabilize dimyristoylphosph

55 Furthermore, mutations disrupting the helical structure abrogate enzymatic activity, implying

56 Here we show that, with helical-structured acoustic metamaterials, it is now pos

57 nd does not affect the ultimate formation of helical structure across a membrane, it correlates with

58 PAGE4 utilizes a transient helical structure adjacent to the central acidic region

59 recent studies suggest the (co)existence of helical structures, albeit in racemic form.

60 The mostly helical structure also shows a beta-sheet motif typical

61 ("passenger") domain that folds into a beta-helical structure and a C-terminal beta-barrel ("beta")

62 purified protein possesses significant alpha-helical structure and appears to be partially disordered

63 conserved BH3 motif that can adopt an alpha-helical structure and bind to a groove on prosurvival pa

64 een distance between two pyrenes on an alpha-helical structure and excimer/monomer (e/m) ratio.

65 la to Pro mutations in the region of NaKtide helical structure and generated several stable cell line

66 ilizing interactions, preserving both triple-helical structure and heterospecificity of assembly.

67 RNP, defining the attributes of its largely helical structure and how polymerase interacts with nucl

68 gs suggest that GTP caps retain the filament helical structure and hydrolysis triggers filament stiff

69 e coefficient was found to be independent of helical structure and long range molecular order, possib

70 nd it is capable of adopting secondary alpha-helical structure and more stable tertiary folding eithe

71 dues, which appear to be essential for alpha-helical structure and oligomerization.

72 design: only Hcy-Cys bridges improve triple-helical structure and stability upon disulfide-bond form

73 usion peptides that exhibit stabilized alpha-helical structure and striking proteolytic resistance.

74 nontrivial interplay between the effects of helical structure and thermal fluctuations on electrosta

75 mplex indicated that E2A-AD1 adopts an alpha-helical structure and uses its PhiXXPhiPhi motif to bind

76 G-quadruplex DNAs form four-stranded helical structures and are proposed to play key roles in

77 eins in mammals, are defined by their triple-helical structures and distinctive Gly-Xaa-Yaa repeating

78 phospholipid vesicles also exhibited highly helical structures and proton transport that is activate

79 l not clear how perversions arise in various helical structures and which universal principles govern

80 (L)(phen)]) are both 1D MOFs (AEPF-16 with a helical structure), and AEPF-17 ([Mg(H(2)O)(L)(phen)]) w

81 nship among base stacking, groove occupancy, helical structure, and DNA bend stiffness.

82 and apoMb at pH 4.1 have significantly less helical structure, and for the latter, that may correspo

83 h these surface ion pairs, destabilizing the helical structure, and perturbing the primary Cd(II) bin

84 We observed that AglR decorated a helical structure, and the AglR helices rotated when cel

85 phorylation, from a random coil to a largely helical structure, and V(19)L(23) becomes more extended

86 All regions encompass coiled-coil or alpha-helical structures, and three are involved in DISC1 olig

87 that loss of hydrophobic bonding and loss of helical structure are key events in the loss of Urc acti

88 ver, indicates that approximately 20% of the helical structures are formed with the "unexpected" hand

89 utions at key positions within the conserved helical structures are shown to provide strong activatin

90 Helical structures are ubiquitous in natural and synthet

91 sequences, presumably adopting more-defined helical structures, are more potent than shorter ones.

92 ynamin proteins assemble into characteristic helical structures around necks of clathrin-coated membr

93 resulting peptide, mast-MO, adopted an alpha-helical structure as determined by NMR, exhibited increa

94 e (CT1-long; Gly-45-Lys-74) exhibit an alpha-helical structure, as determined by CD measurements.

95 by dehydration stimulated it to fold into a helical structure, as it did when the aqueous solution w

96 rich sequences maintain the canonical triple-helical structure at body temperature.

97 The unwinding of the helical structure at the grid walls drives the lens shap

98 ng shape, yet a general principle to realize helical structures at the sub-100 nm scale via colloidal

99 In fact, the steady-state helical structure becomes chaotic when the longest chara

100 otein binding depends not only on the triple-helical structure but also its nucleotide composition.

101 t proteases due to the tightly packed triple-helical structure, but are readily cleaved at a specific

102 that the p55 domain has a predominantly beta-helical structure, but no structural data are available

103 binant proteins studied formed stable triple helical structures, but the stability varied depending o

104 The stabilization of the helical structure by amidation has previously been shown

105 Similarly, disruption of helical structure by proline replacement, either single

106 of Mia40, and chemical induction of an alpha-helical structure by trifluoroethanol suffices to accele

107 lecular level that variations in the F-actin helical structure can be modulated by cooperative bindin

108 These peptides in solution adopt helical structures closely resembling that of ShK.

109 Moreover, a narrowly distributed nonideal helical structure coexists with a broadly distributed id

110 The proteolysis of collagen triple-helical structure (collagenolysis) is a poorly understoo

111 e near their C termini rather than the alpha-helical structure common to peptides that bind related G

112 rent pH values support formation of a triple-helical structure composed of multiple U*A-U base triple

113 erized as type I and maintained their triple-helical structure, confirmed by SDS-PAGE and FTIR.

114 Unique modifications to its core beta-helical structure create a groove on one side of the pro

115 Despite its amphipathic alpha-helical structure, Ctn[1-14] was totally inert toward ba

116 bicity and particle size increased and alpha helical structure decreased, reducing the stability of s

117 mide protons by formation of hydrogen-bonded helical structure during the early folding events has be

118 at the peptide monomer tends to adopt a more helical structure during the hydrogelation as the DMSO/H

119 hat nearly the entire apoA-I molecule adopts helical structure (except for the terminal residues 1-6

120 h is found to contain a highly ordered alpha-helical structure extending from Glu-6 to Lys-63.

121 The helical structure facilitates sampling of H3K4 methylati

122 in of Ag43a displays a twisted L-shaped beta-helical structure firmly stabilized by a 3D hydrogen-bon

123 es, the core of the protein adopts a compact helical structure flanked by flexible N and C termini.

124 er paramyxovirus FPs likely require an alpha-helical structure for efficient membrane disordering and

125 a channel that is predicted to have an alpha-helical structure for protein import.

126 ure of all collagen types is a unique triple-helical structure formed by tandem repeats of the consen

127 Hydrophobic amino acids forming alpha-helical structures frequently line the binding pockets.

128 lymer morphologies, including tetragonal and helical structures, from a combination of polyferrocenyl

129 an interface, consisting of two hydrophobic helical structures, from the HCV E2 surface glycoprotein

130 phase of refolding, attributed to non-native helical structure frustrating microsecond refolding.

131 PVs that lead to hydrogen bonded aggregates, helical structures, gels, nanoparticles, vesicles, mesos

132 tapling of side chains to stabilize an alpha-helical structure has been generally associated with an

133 cleave triple helical collagens, the triple helical structure has to be locally unwound before hydro

134 Contrary to DNA double-helical structures, hydrogen bonds (H-bonds) involving n

135 lian cells, which is usually associated with helical structure, hydrophobicity, and charge density.

136 provide the first observations of extensive helical structure in a histone tail, revealing the inher

137 lpha-helix in the prodomain N terminus adopt helical structure in a membrane-mimetic environment.

138 RemCA switches from unordered to alpha-helical structure in a nonpolar environment.

139 mperature melts indicated that partial alpha-helical structure in cross-linking domains at lower temp

140 minus has previously been found to take up a helical structure in fibrils.

141 tro, the predicted TM domain adopts an alpha-helical structure in lipid environments and can function

142 ontrast to KYE28, KYE28A adopted an extended helical structure in LPS with extended N and C termini.

143 ese mutants do not show patterns of an alpha-helical structure in monomeric and filamentous actin, ir

144 and a better understanding of the control of helical structure in protein folding.

145 UBpep and Ca(2+)/CaM with substantially more helical structure in RUBpep and a global structural chan

146 tion-arresting SP1 mutation T8I also induces helical structure in SP1 and further global dynamical an

147 R AF1 domain to increase the amount of alpha-helical structure in the complex.

148 ve introduced mutations to augment intrinsic helical structure in the F helix of the kinetic folding

149 Second, the alpha-helical structure in the middle of the helix F is replac

150 ral angle bias in the unfolded state and PP2 helical structure in the native state.

151 Results demonstrate that LLP peptides adopt helical structure in the presence of SDS or trifluoroeth

152 Moreover, we observe helical structure in the repeat regions of the MT bindin

153 emical shifts shows the location of residual helical structure in the transient intermediate and iden

154 fore, the alpha clamp and its recognition of helical structure in the translocating substrate play ke

155 y bacterial endonuclease that cleaves double-helical structures in diverse coding and noncoding RNAs.

156 The utility of helical structures in driving motion of microorganisms a

157 ects (NOE) with 600 MHz NMR and CD confirmed helical structures in micelles, which were rationalized

158 s) is an attractive strategy for stabilizing helical structures in N-a-chiral aromatic peptoids, whic

159 if 6 in Xenopus, and similarly located alpha-helical structures in other vertebrate FoxD proteins.

160 pressure, explaining the frequently observed helical structures in pressure-unfolded proteins.

161 ino acid is an effective stabilizer of 3(10) helical structures in short peptides.

162 ybrid HTH" motifs with more than one kind of helical structures in them.

163 n the N-terminus of the B helix to stabilize helical structure (in the mutant G23A/G25A) and to promo

164 retched, almost planar and practically rigid helical structure, inert to external stimuli and prone t

165 ation-dependent conversion of PrP from alpha-helical structures into beta-sheet structures was confir

166 hly conserved within the family, its nascent helical structure is conserved.

167 ar dichroism indicate that the general alpha-helical structure is maintained regardless of cargo load

168 osecond timescale, indicating that the alpha-helical structure is only part of the equilibrium regime

169 ditions, where the fully base-paired, double-helical structure is preserved, is lacking.

170 amic conformational disorder remains and the helical structure is sampled <20% of the time.

171 sis suggests that that the formation of this helical structure is supported by intermolecular interac

172 ions-suggests that deformation of the double-helical structure is the origin of DNA allostery.

173 ide groups in hydrogen-bond stabilization of helical structures is a major factor, which determines s

174 ntigenic peptides from random coils to alpha-helical structure, is important for antigen loading insi

175 ntrinsic W423 fluorescence and induced alpha-helical structure, it is inferred that binding of LPG ne

176 nucleotides can fold into quadruple-stranded helical structures known as G-quadruplexes.

177 tatricopeptide repeat (PPR) motifs are alpha-helical structures known for their modular recognition o

178 f hydrophobic interactions, ionic bonds, and helical structure, leads to Urc inactivation and aggrega

179 ed and regulated and suggest that RNA triple-helical structures likely have key regulatory functions

180 The p55 domain, composed primarily of beta-helical structures, localizes to the peripheral arms, wh

181 wo-state mechanism, with loss of ~20% of the helical structure, loss of the majority of the tertiary

182 The helical-structured metamaterials present a non-dispersiv

183 The helical-structured metamaterials will have profound impa

184 ally and experimentally demonstrate that the helical-structured metamaterials with designed inhomogen

185 eated to produce a predicted amount of alpha-helical structure: mostly helical, some helical, and no

186 Because of their intricate helical structure, new properties of CLC have emerged re

187 characterization of non-Watson-Crick double-helical structures; new structural parameters that integ

188 tyrosine into the cationic polypeptide, the helical structure of AMPs was distorted owing to the sid

189 The triple-helical structure of collagen, the most abundant protein

190 otation, inducing twisting that results in a helical structure of defined chirality.

191 in a significant stabilization of the double-helical structure of DNA against thermal denaturation.

192 acids and amino acids is responsible for the helical structure of DNA and proteins, which in turn lea

193 s in which the intrinsic chirality of double helical structure of DNA forms the primary determinant o

194 The double-helical structure of DNA results from canonical base pai

195 y time, shortly after the discoveries of the helical structure of DNA, the central dogma of DNA to RN

196 nA(1-300)-induced cooperative changes in the helical structure of F-actin and observe the binding coo

197 The double-helical structure of genomic DNA is both elegant and fun

198 endence suggests that the negatively charged helical structure of heparin electrostatically complemen

199 idues that contain a bulky side chain in the helical structure of NaKtide by alanine abolished the in

200 Circular dichroism measurements confirmed helical structure of peptides in lipid bilayer, in the p

201 dicated by an overall reduction of the alpha-helical structure of proteins and increase in the concen

202 veals that both lobes of CaM collapse onto a helical structure of PSD-95 formed at its N-terminus (re

203 In apo-IC, the helical structure of region 1, the nascent helix of regi

204 ed binding surface of Juno may recognize the helical structure of the amino-terminal domain of Izumo1

205 the monomeric protein reveals that the beta-helical structure of the p55 domain extends into the C-t

206 esults provide support for the idea that the helical structure of the p75(NTR) transmembrane domain,

207 liquid versus solid) on chirality, the alpha-helical structure of the positively charged polypeptide

208 that substrate dimerization and/or the alpha-helical structure of the substrate can regulate the site

209 ons induce distinct alterations in the alpha-helical structure of the TILRR core protein.

210 of Lys(63)-linked diubiquitin stabilizes the helical structure of the UIM domain and that the corresp

211 emonstrate that phosphorylation distorts the helical structure of TIRAP PBM, reducing PI interactions

212 eport our observations of multiple staggered helical structures of two canonical coiled coils.

213 s are disordered, whereas Ca(2+)/CaM imposed helical structure on both KCNQ A and B domains.

214 sformations by either intensifying the alpha helical structure or changing from alpha helical to beta

215 e synthesis results in the alteration of DNA helical structure or reduced thermal stabilities.

216 taining anionic lipids, (ii) adopts an alpha-helical structure oriented in plane with respect to the

217 osteric site preferentially recognizes alpha-helical structure over beta-sheet structure.

218 lucidate the macroscopic distribution of the helical structure over the entire shell (~1 mm), the str

219 cture prediction programs predicted an alpha-helical structure overlapping with amphibian-specific Mo

220 tions with various chemical groups and alpha-helical structure presented by the unfolding polypeptide

221 The one-dimensional helical structures presented in this study are unique be

222 erged as one such solution, conferring alpha-helical structure, protease resistance, cellular penetra

223 gammaTuSCs associate laterally into helical structures, providing a structural template for

224 ability-the stiff, naturally straight double-helical structure-rather than to the unique features of

225 Thus, DcuS contains a long alpha-helical structure reaching from the sensory PAS(P) (alph

226 ure of AdhE and suggests that the high-order helical structure regulates its enzymatic activity.

227 ed domains dominated by beta sheet and alpha helical structure, respectively.

228 symmetry space by efficient modeling of the helical structure restrained by interprotomer ssNMR dist

229 Mutations predicted to disrupt the alpha-helical structure resulted in a significant decrease in

230 of a peptide that abrogates the formation of helical structure resulted in poor loading efficiency.

231 main showed that disruption of the signature helical structure resulted in the loss of gamma-secretas

232 the Q/H segments adopt minor populations of helical structure, show decreased mobility and start to

233 tations that closely resemble ideal sheet or helical structures, similar non-ideal structures at PPI

234 The mutation profoundly impacts helical structure stability of D25V-variant, which is re

235 A perversion in an otherwise uniform helical structure, such as a climbing plant tendril, ref

236 ur data establish a locally perturbed double helical structure that accommodates the bulky adduct by

237 of apoA-IV shows that it adopts an elongated helical structure that dimerizes via two long reciprocat

238 ed to aqueous and is potentially folded in a helical structure that intimately interacts with the NBC

239 a classical NLS at the far C terminus of its helical structure that is conserved only in two genera o

240 type 2 dUTPase (DutNM1), which has an alpha-helical structure that is distinct from the type 1 trime

241 H C terminus forms a stable membrane binding helical structure that is important for CLD secretion.

242 ubic phase bilayer, yielding a dimeric alpha-helical structure that is in excellent agreement with pr

243 C terminus is an independently folding alpha-helical structure that is relatively resistant to urea d

244 a major contribution from H3, which adopts a helical structure that projects into a deep, wide groove

245 The 3' end forms a novel triple-helical structure that supports export and translation a

246 The two parallel cable elements form twisted helical structures that are connected by transversal fil

247 nus of PduP and C terminus of PduA both form helical structures that bind one another via the key res

248 aggregates, whereas inhibitors induce alpha-helical structures that form stable dimeric/trimeric oli

249 Well-defined helical structures that have been identified in several

250 s that, through the recognition of unfolding helical structure, the alpha clamp can accelerate the ra

251 ible expansion linker contracts to a compact helical structure, the CTD translates 6 A and becomes te

252 Aside from stabilizing helical structures, the ketone moiety embedded in the li

253 change from compact random coil to extended helical structure-the disappearance of a band at 495 nm

254 tution expected to break the predicted alpha-helical structure; this significantly reduced FoxD4L1's

255 Cd(II), the Glu residues stabilize the three-helical structure though salt bridge interactions with s

256 ble-helical DNA is capable of forming triple-helical structures through Hoogsteen and reverse Hoogste

257 ated by bacterial phosphatase to restore the helical structure, thus contributing to strong membrane

258 g domain in hRpn10 locks into a well-defined helical structure to form an intermolecular 4-helix bund

259 Subunit b contributes a central alpha-helical structure to the peripheral stalk, extending fro

260 ightforward approach for the design of alpha-helical structure to validate the knob-socket model.

261 characterized by a seven-transmembrane alpha-helical structure, transmitting extracellular signals in

262 In contrast to the ideal alpha-helical structures typically assumed in mechanistic mode

263 fully hydrated conditions and acquired alpha-helical structure upon drying and in the presence of tri

264 es coupled folding and binding to form alpha-helical structure upon interacting with KIX.

265 tion resulted in the formation of a straight helical structure upon the neutralization of the hinge h

266 ral region of the Nterm domain adopted alpha-helical structure upon titration of Nterm and Nterm-ACB

267 ondary structural motifs, including an alpha-helical structure, upon binding to cyclin-dependent kina

268 ch agrees favorably with the prediction of a helical structure using molecular modeling.

269 The relaxation of helical structures very close to equilibrium is observed

270 ation enthalpy that indicates loss of double helical structure was found highest in Mushki budgi (9.7

271 alpha-syn involves anionic phospholipids and helical structure, we discovered that the protein deform

272 h the aim of modulating the stiffness of the helical structure, we investigated the effect, using NMR

273 is an all-or-none process related to loss of helical structure, weak unfolding and ejection of the pr

274 ular dichroism revealed an amphiphilic alpha-helical structure when reconstituted in lipid vesicles,

275 the active peptides adopted highly coiled to helical structures when bound to a membrane surface.

276 nism for pH-controlled structural changes in helical structures when histidines act as the pH sensor.

277 We find that CsgA forms a beta-helical structure, where each turn corresponds to previo

278 ies suggest that PrPC is enriched with alpha-helical structure, whereas PrPSc contains a high proport

279 with micelles stabilizing a particular alpha-helical structure, whereas submicellar lipids stabilize

280 r, this interaction leads to a change in the helical structure, which alters G-domain interactions to

281 he assembly adopts the polyproline II (PPII) helical structure, which brings the chromophores into cl

282 ding/refolding process, a loss/gain of alpha-helical structure, which did not disrupt the capsid inte

283 acid at a time, without altering their alpha-helical structure, which is required for correct antigen

284 o observe repeated formation and breaking of helical structure, which we found to occur on a multimic

285 gens three polypeptides form a unique triple-helical structure with a one-residue stagger to fit ever

286 tide in a lipid bilayer demonstrate a stable helical structure with an average tilt of 24 degrees, wi

287 tive mutations to the NTD, suggesting that a helical structure with defined orientation in the membra

288 The protein-free RNA aptamer adopts a helical structure with multiple non-canonical base pairs

289 a self-assembled one-dimensionally periodic helical structure with pitch [Formula: see text] in the

290 amide 2c generates, in a cooperative manner, helical structures with a preferred handedness in a proc

291 may effectively operate as three-dimensional helical structures with broadband bianisotropic optical

292 appropriate length and sequence form triple-helical structures with purine-rich sequences of duplex

293 how that BASIC contains an amphiphilic alpha-helical structure within its N-terminal domain.

294 rop, at least some lambda*YA forms misplaced helical structure within microseconds.

295 dicated that the T43I substitution increases helical structure within the TM domain of C55.

296 hydrophilic segment adopted a stable, alpha-helical structure within the tunnel when the most C-term

297 on of the Q239-D258 fragment confirmed alpha-helical structures within the linker, with a short beta-

298 The natural collagen domain forms a triple helical structure without 4-hydroxylation of proline at

299 e, cell-derived alpha-synuclein showed alpha-helical structure without lipid addition and had much gr

300 uin Zn(2+)-tetrathiolate and a loss of alpha-helical structure without overall thermal destabilizatio