ライフサイエンスコーパス: helicase

1 icantly higher than the closely related UvrD helicase.

2 One of these factors is the nsp13 helicase.

3 ring uncoupled from the Cdc45-MCM-GINS (CMG) helicase.

4 ion is performed by the Cdc45-MCM-GINS (CMG) helicase.

5 int kinase, and require unwinding by the WRN helicase.

6 smission through the nonstructural protein 3 helicase.

7 ATP-dependent nonstructural protein 3 (NS3) helicase.

8 te specificity and processivity of the DDX43 helicase.

9 t in complex with two molecules of the nsp13 helicase.

10 ed six mutations in rqh1 encoding a RecQ DNA helicase.

11 , affecting a subunit of the MCM replicative helicase.

12 (hPSC) lacking either functional WRN or BLM helicase.

13 The third protein, Cch2, is a 3'-to-5' helicase.

14 through interaction with the MCM replicative helicase.

15 , reminiscent of the "arginine clamp" of RNA helicases.

16 s are largely driven by eight DExD/H-box RNA helicases.

17 nisms of regulation of unwinding by Rep-like helicases.

18 miting strand rejection by the Sgs1 and Mph1 helicases.

19 ions in BRCA1 interacting protein C-terminal helicase 1 (BRIP1) are associated with ovarian carcinoma

20 that RTEL1 (regulator of telomere elongation helicase 1) has a genome-wide role in MiDAS at loci pron

21 t two host mRNA processing factors, DEAH-box helicase 15 (DHX15) and cleavage and polyadenylation spe

22 RNA helicase DDX21 (also named nucleolar RNA helicase 2) is a nuclear autoantigen with undefined role

23 DEAD-Box Helicase 3 X-Linked (DDX3X) is frequently mutated in the

24 inding protein (RBP)/helicase DDX3 (DEAD-box helicase 3 X-linked) is a key component of stress granul

25 molog of the disease-linked enzyme RecQ-like helicase 4 (RECQL4), as a component of Pso2-mediated ICL

26 DEAD-box helicase 5 (DDX5) is a founding member of the DEAD-box R

27 ble-stranded RNA (dsRNA) receptor DExD/H-Box Helicase 58 (DDX58/RIG-I).

28 induction of IFN-stimulated genes DExD/H-box helicase 58, MX dynamin-like GTPase 1, and IFN-induced p

29 Nuclear RNA helicase A (DHX9/RHA) is necessary for the translation o

30 We recently identified the Hrq1 helicase, a homolog of the disease-linked enzyme RecQ-li

31 ce (RNAi) factor ERI-6/7, a homolog of MOV10 helicase, a retrotransposon and retrovirus restriction f

32 derscoring the significance of plasticity in helicase action.

33 st transition to single-stranded (ss)DNA for helicase action.

34 trigger larger domain movements required for helicase action.

35 into the molecular basis of G-patch-mediated helicase activation is missing.

36 Low level activation of CDK2 mediates helicase activation, cell cycle progression, and both re

37 f Cas3, which contains both the nuclease and helicase activities required for DNA cleavage during int

38 efine the linkage between ATP hydrolysis and helicase activities within NS3 and provide insight into

39 ing that flaviviruses may use suboptimal NS3 helicase activity for optimal genome replication.

40 -like large effector complex subunit and the helicase activity in a separate Cas3' subunit, but the f

41 We demonstrate an RNA-DNA helicase activity in UAP56 and show that its overexpress

42 They found that UAP56 helicase activity is required to remove R loops formed f

43 tive splicing of target exons due to the RNA helicase activity of DDX17.

44 Mechanistically, MCM8IP stimulates the helicase activity of MCM8-9.

45 C-terminal domain significantly reduced the helicase activity of nsp10, indicating that the four dom

46 in the helicase domain, indicating that the helicase activity of Rqh1 plays an important role in the

47 While p44 is known to regulate the helicase activity of XPD during NER, p62 is thought to b

48 Here, by analyzing in vitro helicase activity, dissociation of UPF1 from purified mR

49 3X missense mutations profoundly disrupt RNA helicase activity, induce ectopic RNA-protein granules i

50 winding at replication forks by limiting CMG helicase activity, suggesting a mechanism for fork stabi

51 late DNA at the replication fork impairs its helicase activity, which is alleviated by binding of the

52 ructure, which plays a crucial role in nsp10 helicase activity.

53 tiation factor 4A (eIF4A) and inhibiting its helicase activity.

54 ase, 5' to 3' ssDNA translocase and 5' to 3' helicase activity.

55 lso suggests that two mutations in the nsp13 helicase allowed for the adaptation of the virus to the

56 Here, using helicase and adenosine triphosphatase assays we show tha

57 We have used HCV NS3 helicase and fluoroquinolones as a model for drug-protei

58 FANCJ, a DNA helicase and interacting partner of the tumor suppressor

59 Disruption of the balance between helicase and polymerase activities during replication st

60 at protein fork blocks, the coupling of DNA helicase and polymerase functions during replication str

61 d displays intermittent coupling between the helicase and polymerase(s).

62 ticipated roles for the Escherichia coli Rep helicase and RecA recombinase in tolerating toxicity ind

63 These results show how tight coupling of the helicase and topoisomerase activities allows for inducti

64 RNA helicases and E3 ubiquitin ligases mediate many critical

65 atively slow duplex unwinding by replicative helicases and explains how replisome components that int

66 However, pin structures vary among helicases and it remains unclear whether they confer a c

67 may have evolved as a trimer to organize two helicases and one Pol alpha-primase into a replication f

68 e bivalent ALYREF protein to bridge adjacent helicases and regulate the TREX-mRNA interaction.

69 n of slow DNA unwinding rates by replicative helicases and the mechanism by which other replication c

70 interactions such that codeficiency of some helicases and their genetically interacting proteins res

71 rules of engagement may apply to diverse RNA helicases and TRIM/TRIM-like proteins.

72 ly conserved rules of engagement between RNA helicases and tripartite motif (TRIM) E3 ligases that le

73 DNA polymerase from the replication fork DNA helicase, and 2) on the damaged template, nascent leadin

74 V inhibition, while its P-body localization, helicase, and ATP-binding functions are not required.

75 Concomitantly, RNA affinity, helicase, and ATPase activity of DHX15 are increased whe

76 e is a structure-specific nuclease, 5'-to-3' helicase, and DNA-dependent ATPase.

77 ty is specific to eukaryotic RecQ4 subfamily helicases, and genetic and biochemical data suggest that

78 Helicases are enzymes that move, manage, and manipulate

79 Two UAP56/DDX39B RNA helicases are juxtaposed at each end of the tetramer, wh

80 ependent recombination, possibly mediated by helicases, are suppressed by exonucleases ExoI and RecJ.

81 me, these observations suggest a role of the helicase as the central organizing hub.

82 MCM-BP, which interacts with subunits of MCM helicase, as a protein whose downregulation results in t

83 endencies, the Werner syndrome ATP-dependent helicase, as a synthetic lethal target in tumours from m

84 risation region to dock onto the side of the helicase assembly formed by Cdc45 and GINS.

85 MTR4 is a RNA helicase associated with a nuclear exosome that plays ke

86 tures have not been reported for replicative helicases at a replication fork at atomic resolution, a

87 Replication is controlled by loading of helicases at origins of replication, activation to prefe

88 ated that acetylation of Pif1 stimulated its helicase, ATPase, and DNA-binding activities, whereas ma

89 h the parental duplex, DNA rezipping-induced helicase backtracking reestablishes productive helicase-

90 The RNA helicase bad response to refrigeration 2 homolog (BRR2)

91 on and regulation as in the spliceosomal RNA helicase Brr2.

92 em-loops can transiently escape the ribosome helicase by binding to the A site.

93 acid helicases whose members comprise tandem helicase cassettes.

94 ctural analysis revealed conservation of the helicase catalytic domain across the order Nidovirales (

95 ough the elongating ribosome is an efficient helicase, certain mRNA stem-loop structures are known to

96 RNA triggers are ATP-sensitive, regulated by helicase/chaperone activity, and exhibit the hallmarks o

97 The eukaryotic replicative helicase CMG is a closed ring around double-stranded (ds

98 cessive DNA unwinding by the replicative DNA helicase, CMG, demonstrating that budding yeast replisom

99 at an ICL protects against DNA2-WRN nuclease-helicase complex and not the MRE11 nuclease that is impl

100 at MCM8IP directly associates with MCM8-9, a helicase complex mutated in primary ovarian insufficienc

101 que long 52 (UL-52; component of DNA primase/helicase complex), Circ, bICP4, and IEtu2 were stimulate

102 ryotic replicative CMG (Cdc45, Mcm2-7, GINS) helicase contains a Mcm2-7 motor ring, with the N-tier r

103 DHX36 contains the superfamily 2 helicase core and several auxiliary domains that are con

104 ndicate that nidoviruses contain a conserved helicase core domain and key amino acid sites affecting

105 zinc-binding domain (ZBD), a 1B domain, and helicase core domains 1A and 2A.

106 DEAH helicases couple adenosine triphosphate (ATP) hydrolysis

107 results suggest a role for the bacterial RNA helicase CrhR in RNase E-dependent mRNA processing in Sy

108 equires interaction with and activity of the helicase DDX11.

109 DEAD-box RNA helicase DDX21 (also named nucleolar RNA helicase 2) is

110 We show that PRL3 binds to the RNA helicase DDX21, thereby restricting productive transcrip

111 RNA-binding protein (RBP)/helicase DDX3 (DEAD-box helicase 3 X-linked) is a key co

112 De novo germline mutations in the RNA helicase DDX3X account for 1%-3% of unexplained intellec

113 The human DEAD-box RNA helicase DDX3X is an essential cofactor for viral replic

114 Neuron, Cheng et al. (2019) report that the helicase DDX3X, which unwinds (or relaxes) RNA, suppress

115 nsically disordered region (IDR) of DEAD-box helicase Ddx4, as a test case, to assess roles of electr

116 Recently, we found that the DEAD-box helicase DDX43 contains a KH domain in its N-terminus; h

117 Yeast DEAD-box helicase Ded1 stimulates translation initiation, particu

118 Here, we report that RECQL4 DNA helicase, deficient in the cancer-prone and premature ag

119 ly observed with wild-type DNA2, but not the helicase-deficient variant.

120 cleic acid sequence-based amplification, and helicase-dependent amplification.

121 Here, we have solved the structure of human helicase DHX15/Prp43, which has a dual role in splicing

122 The DEAH/RHA helicase DHX36 has been linked to cellular RNA and DNA q

123 s overcome through activity of a G4-specific helicase DHX36, increasing K+ leak currents and membrane

124 nd nucleolar proteins including the DEAD box helicases, DHX9, DDX5 and DDX17.

125 e nucleic acid-binding ATPase domains of the helicase directly in front of the replicating-transcribi

126 ed ASC-1 complex (ASCC) containing the ASCC3 helicase disassembles the leading ribosome in an ATP-dep

127 on processivity from 1750 to >9000 bp before helicase disassociation, suggesting that more than half

128 f FACT during replication stress, the MCM2-7 helicase dissociates from chromatin, resulting in the ab

129 a novel role for FACT as a factor preventing helicase dissociation from chromatin during replication

130 Here, we identify the Chromodomain Helicase DNA Binding Protein 7 (CHD7), which is frequent

131 n remodeling protein gene CHD7 (Chromodomain helicase DNA binding protein 7).

132 Here we report that chromodomain helicase DNA-binding protein 4 (CHD4) physically interac

133 been applied to study various motors such as helicases, DNA and RNA polymerases, topoisomerases, nucl

134 tion of the chromatin remodeler chromodomain-helicase-DNA-binding protein 7 (CHD7) expanded phenotypi

135 ich codes for the protein CHD8 [chromodomain-helicase-DNA-binding protein 8]) are among the most comm

136 direction, and facilitate the loading of the helicase DnaB onto the DNA to restart replication.

137 ns: an Origin Binding Domain (OBD) and a SF3 helicase domain (HD).

138 nce on the N terminus (Lys-118 and Lys-129), helicase domain (Lys-525, Lys-639, and Lys-725), and C t

139 n (A287V) or adaptive mutations in the RecA2 helicase domain (T358S or V410I).

140 similarity with other PVs, except for an SF3 helicase domain in its nonstructural protein.

141 d a Chi hotspot-deficient mutant in the RecB helicase domain located > 45 A from both the Chi-recogni

142 gest that novel missense variants within the helicase domain of BRIP1 may confer risk for both breast

143 The DNA helicase domain of DDX11 is essential for sister chromat

144 h1 is highly conserved, and mutations in the helicase domain of these human enzymes may cause the che

145 This activity is provided by the C-terminal helicase domain of viral nonstructural protein 3 (NS3).

146 sed by silencing of Dicer-2, which has a RNA helicase domain similar to MDA5 that senses unedited dsR

147 and the other is homologous to the Poltheta helicase domain, called Poltheta-polymerase and Poltheta

148 t for a start codon mutation, are all in the helicase domain, indicating that the helicase activity o

149 otspot missense mutations within the SMARCA4 helicase domain.

150 e receptors (RLRs), viral RNA receptors with helicase domains, interact with their cognate TRIM/TRIM-

151 e E3 ligases through similar epitopes in the helicase domains.

152 on of the protein, distinct from its PHD and helicase domains.

153 RCA1 and BRCA2, CtIP deficiency promoted the helicase-driven destabilization of RAD51 nucleofilaments

154 We also found that an RNA helicase, eIF4A, independently accelerated eIF4E-cap ass

155 X5) is a founding member of the DEAD-box RNA helicase family, a group of enzymes that regulate ribonu

156 the budding yeast ortholog of Fanconi anemia helicase FANCM, prevents precocious DSB strand exchange

157 propose that Pif1 is a general displacement helicase for replication bypass of both R-loops and prot

158 licase backtracking reestablishes productive helicase-fork engagement, underscoring the significance

159 plex of Frequency (FRQ), FRQ-interacting RNA helicase (FRH), and casein kinase I (CKI), which inhibit

160 iated decay (NMD) by preventing the UPF1 RNA helicase from associating with potential decay targets.

161 urther our understanding of the mechanism of helicase function and provide new targets for the develo

162 ly, primarily mutations that compromise priA helicase function or recA promoter mutations that reduce

163 re domain and key amino acid sites affecting helicase function, which share a common mechanism of hel

164 loops, in a process that is dependent on its helicase function.

165 biophysical mechanisms for ATPase-driven NS3 helicase function.

166 four domains must cooperate to contribute to helicase function.

167 In general, all helicases function by converting the chemical energy sto

168 In Saccharomyces cerevisiae, the Pif1 helicase functions in both nuclear and mitochondrial DNA

169 sence/absence of a unique UvrD/PcrA/Rep-like helicase gene immediately downstream in the genome.

170 Variation in the BLM helicase gene resulted in defects in the DNA repair mech

171 impacting protein synthesis: a ribosomal RNA helicase gene, tRNA biosynthesis genes, and a gene contr

172 Replicative helicases generally unwind duplex DNA an order of magnit

173 demonstrated by the linkage of mutations in helicase genes to hereditary disorders with defects in D

174 probably damaging variants in DExD/H-box RNA helicase genes.

175 DNA helicases have risen to the forefront as genome caretake

176 y role of LANA and identified a cellular RNA helicase, hnRNP A1, regulating the translation of LANA m

177 DNA2 is an essential nuclease-helicase implicated in DNA repair, lagging-strand DNA sy

178 ding the sole Asp-Glu-Ala-Asp (DEAD)-box RNA helicase in Synechocystis sp. PCC 6803, crhR (slr0083),

179 -like receptors and DEAD-box or DEAH-box RNA helicases in an orchestrated RNA-sensing network and als

180 ely, accumulating evidence suggests that DNA helicases in cancer cells have a network of pathway inte

181 We discuss the roles of RECQ DNA helicases in cancer, emphasizing some of the more recent

182 is for further understanding the function of helicases in the order Nidovirales.

183 CL repair and establish a role for the RecQ4 helicases in the repair of these detrimental DNA lesions

184 t, we identify roles for the HR factors Rqh1 helicase, in concert with Rad55, in suppressing dnTA at

185 n support of this notion, integration of two helicase-inactive mutations or deletion of rqh1 generate

186 the structure and function of these DEAH-box helicases, including new information provided by recent

187 However, it is unclear how most RNA helicases interact with ribosome assembly intermediates

188 at PDS5 proteins are required to recruit WRN helicase-interacting protein 1 (WRNIP1), RAD51 recombina

189 as a modulator of ATP-dependent DEAD-box RNA helicases involved in messenger (m)RNA export, translati

190 DNA2 nuclease/helicase is a structure-specific nuclease, 5'-to-3' heli

191 Twinkle helicase is an essential component of mtDNA replication.

192 ion termination, the CMG (Cdc45-MCM2-7-GINS) helicase is polyubiquitylated by CRL2(Lrr1) and unloaded

193 s inhibited even with SSBs present, and Pif1 helicase is required.

194 or 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase, is a critical component of the eIF4F complex,

195 re, we investigated the mechanism by which a helicase-like factor HelD recycles RNAP.

196 ry connections between TRIM proteins and RNA helicases, linking ubiquitin and RNA biology throughout

197 cation origins serve as sites of replicative helicase loading.

198 hromatin remodeling factor lymphoid-specific helicase (LSH), an epigenetic driver of NSCLC.

199 Mutation of HELLS (Helicase, Lymphoid-Specific)/Lsh in human DNA causes a s

200 censed by the loading of the replicative DNA helicase, Mcm2-7, in inactive double hexameric form arou

201 nding affinity, ATP hydrolysis activity, and helicase-mediated unwinding activity.

202 et of mRNAs through its interaction with RNA helicase Moloney leukemia virus 10 (MOV10).

203 r data highlight the central role of the RNA helicase Mtl1 in regulation of the complex and provide i

204 These include the DEAH-box RNA helicase Mtr4 together with an RNA-binding protein (Air1

205 al developmental arrest phenotype of the RNA helicase mutant and identified genes involved in ribosom

206 Rad3 signaling and partially rescued a rqh1 helicase mutant.

207 As a member of the superfamily 2 (SF2) helicases, NS3 requires the binding and hydrolysis of AT

208 PRRSV helicase nsp10 is a multifunctional protein with translo

209 PRRSV helicase nsp10 is an important component of the replicat

210 ultiple activities of enterobacterial RecBCD helicase-nuclease are coordinated by Chi recombination h

211 he ribonucleoprotein complex Cascade and the helicase-nuclease Cas3(4,5), but nuclease-deficient type

212 Bacterial RecBCD helicase-nuclease must coordinate DNA unwinding and cutt

213 llus stearothermophilus Bad, a bacterial DNA helicase-nuclease with similarity to human DNA2.

214 ding the biochemical properties of DNA2-like helicase-nucleases and DNA looping motor proteins in gen

215 RNA helicases of the DEAH/RHA family are involved in many es

216 DNA helicases of the RecQ family are conserved among the thr

217 ing CDC6, and assembling the MCM replicative helicase on DNA.

218 we investigated the role of the Kunjin virus helicase on infection in cell culture and in vivo This w

219 e on the 5'-ended strand and its slower RecB helicase on the 3'-ended strand.

220 A end, RecBCD unwinds DNA with its fast RecD helicase on the 5'-ended strand and its slower RecB heli

221 and, with the help of Cdt1, the core Mcm2-7 helicase onto DNA.

222 ing ATPase that loads the Mcm2-7 replicative helicase onto replication origins.

223 ing secondary structures in template, slowed helicase, or uncoupled helicase-polymerase, increase DNA

224 e, organized around the Cdc45-MCM-GINS (CMG) helicase, orchestrates chromosome replication.

225 the "NM_000057.3" transcript expressing BLM helicase (P54132).

226 Interestingly, the four helicases participating in the late stages of splicing a

227 A and S411A in motif V exhibit a hyperactive helicase phenotype, leading to the regulation of translo

228 Polo-like kinase 1-interacting checkpoint helicase (PICH) is a DNA translocase essential for chrom

229 ity is reversed by deletion of the conserved helicase PIF1 and/or DNA damage checkpoint-mediator RAD9

230 Overexpressing the G4-DNA helicase Pif1 in neurons exposed to the G4 stabilizer im

231 All eukaryotes contain the accessory helicase Pif1, which tracks in a 5'-3' direction on sing

232 fic manner by the ATP-dependent G4-resolving helicase Pif1.

233 occurs only in the presence of the 5'-3' DNA helicase Pif1.

234 RNA helicases play various roles in ribosome biogenesis depe

235 h unwinding and the DNA path through the CMG helicase-Pol epsilon-PCNA clamp.

236 somes lack intrinsic mechanisms that control helicase-polymerase coupling at the fork.

237 Leading-strand template aberrations cause helicase-polymerase uncoupling and impede replication fo

238 s in template, slowed helicase, or uncoupled helicase-polymerase, increase DNA reannealing and polyme

239 Finally, we found that the full-length DDX43 helicase prefers DNA or RNA substrates with TTGT or UUGU

240 alled DNA replication forks requires the DNA helicase PriA.

241 ts indicate that PcrA is a highly processive helicase prone to stochastic pausing, resulting in avera

242 We propose that DDX11 is a DNA helicase protecting against G4 induced double-stranded b

243 esults in the unidirectional movement of the helicase protein along one strand of a nucleic acid.

244 proteomics, we found that Pgr binds the RNA helicase protein Ddx21.

245 The BLM helicase protein plays a vital role in DNA replication a

246 S3 protease complex and 5 hinges in the NS3- helicase protein.

247 Despite extensive investigation of helicase proteins in humans, no attempt has previously b

248 DEAD-box helicase proteins perform ATP-dependent rearrangements o

249 MCM2-7, PCNA, RPA1) and RNA metabolism (RNA helicases, PRP19, p54(nrb), splicing factors).

250 least partially complemented by another SF2 helicase, RadD.

251 nd sensitizes it to cut DNA when the leading helicase RecD stops at the DNA end.

252 The SF2 helicase RecG is a key enzyme in the processing of postr

253 on ISG15 functional interaction with the DNA helicase RECQ1, which promotes restart of stalled replic

254 Here, we show that DHX34, an RNA helicase regulating NMD initiation, directly interacts w

255 D substrates, presenting a new model for RNA helicase regulation and target selection in the NMD path

256 s RNA processing role, UAP56/DDX39B is a key helicase required to eliminate harmful cotranscriptional

257 y biallelic disruption of the WRN or BLM DNA helicases respectively.

258 ain, called Poltheta-polymerase and Poltheta-helicase, respectively.

259 DNA unwinding by Bloom (BLM) or Werner (WRN) helicase, RPA directs the DNA2 nuclease to degrade the 5

260 is the primary resection nuclease, with the helicase Rqh1 playing a minor role.

261 e and the rest of the complex, with the Snf2 helicase-SANT associated (HSA) domain connecting all mod

262 inding induces a helical conformation in the helicase-SANT-associated (HSA) domain of Sth1.

263 Ski8 (Ski) complex containing the 3'->5' RNA helicase Ski2 binds to 80S ribosomes near the mRNA entra

264 which other replication components increase helicase speed are unclear.

265 that participates in stabilizing the overall helicase structure.

266 genes encoding members of the DExD/H-box RNA helicase superfamily might also underlie developmental d

267 binds in an extended conformation across the helicase surface.

268 SrmB is a DEAD-box helicase that acts early in the ribosome assembly proces

269 ex, the inactive form of the DNA replicative helicase that is assembled onto DNA in G1-phase (also kn

270 e focus on the host restriction factor DHX30 helicase that is countered by the NS1 protein, and estab

271 ex is a dual-cassette Ski2-like nucleic acid helicase that provides single-stranded DNA for alkylatio

272 dentify UAP56 as a cotranscriptional RNA-DNA helicase that unwinds R loops.

273 Mcm10 activates CMGs to form helicases that encircle single-strand (ss) DNA and initi

274 Cells use accessory helicases that help the replisome bypass difficult barri

275 the late stages of splicing are all DEAH-box helicases that share structural similarities.

276 The MOV10L1/Armitage RNA helicase then facilitates the translocation of ribosomes

277 lnerability of the D-loop to dissociation by helicases, thereby promoting ectopic telomere formation.

278 ng domain that works together with the DDX11 helicase to facilitate replication of G4 DNA structures.

279 Addition of CHK1i re-activates the DNA helicase to unwind DNA, but in the absence of dNTPs, thi

280 he RNase L-cleaved dsRNAs signal to Rig-like helicases to amplify IFN production.

281 function, which share a common mechanism of helicase translocation and unwinding activity.

282 tively affect the activity of the N-terminal helicase unit from a distance.

283 have used magnetic tweezers to monitor PcrA helicase unwinding and its relationship with the nicking

284 S3 reduce viral replication and increase the helicase-unwinding turnover rates by 1.7- and 3.5-fold,

285 A ring-shaped helicase unwinds DNA during chromosome replication in al

286 he polymerase holoenzyme and the replicative helicase upon association of the primase with the replis

287 a pathway homologous to the mammalian RIG-I helicase viral response pathway.

288 telomeric DNA in part by recruiting the BLM helicase, which can resolve G-quadruplexes on the laggin

289 n ectopic telomere is promoted by Mph1/FANCM helicase, which has the capacity to disassemble D-loops.

290 ted DNA damage response in cells lacking Rep helicase, which is an enzyme that disrupts stalled trans

291 ukaryotic replisome assembles around the CMG helicase, which stably associates with DNA replication f

292 in A1 (hnRNP A1) as a G-quadruplex-unwinding helicase, which unfolds these stable secondary structure

293 erved set of proteins including UPF1, an RNA helicase whose ATPase activity is essential for NMD.

294 distinct subgroup of Ski2-like nucleic acid helicases whose members comprise tandem helicase cassett

295 plex unwinding is then performed by the PcrA helicase, whose processivity is critically promoted by i

296 strate that engagement of the eukaryotic CMG helicase with template DNA at the replication fork impai

297 nserved, essential regulator of DEAD-box RNA helicases, with critical roles defined in mRNA export, t

298 The RecQ DNA helicase WRN is a synthetic lethal target for cancer cel

299 The DNA helicase XPB plays a key role in DNA opening and coordin

300 l transcription factor TFIIH, containing the helicases XPB, XPD and five 'structural' subunits, p62,