ライフサイエンスコーパス: helper

1 precursors, two trajectories developed as T helper 1 (T(H)1) and follicular helper T (T(FH)) transcr

2 A large body of evidence indicates that T helper 1 (T(H)1) cells have pro-atherogenic roles and re

3 after treatment and a higher percentage of T helper 1 (Th1) and NK cells.

4 he ligand and chemoattractant for CXCR3(+) T-helper 1 (Th1) cells.

5 sion of activated lymphocytes, switch to a T helper 1 (Th1) regulatory pattern, and Th17 reduction.

6 s, was antigen dose-sparing, and induced a T helper 1 (Th1) response.

7 IL-12/23p40 in DCs may promote priming of T helper 1 (Th1) responses.

8 ion without adequate counter-regulation by T-helper 1 cell and regulatory T cell activity.

9 A small number of regulatory T cells and T helper 1 cells is also identified.

10 cytokine interleukin-4 (IL-4), but not the T helper 1 cytokine interferon-gamma (IFN-gamma).

11 notypes of interest: (1) a population with T helper 1 function that was increased with iNKT activatio

12 a cellular immune response with favourable T helper 1 polarization, as profiled in mice.

13 ion resolution, including dampening of the T helper 1 response, alternative activation of macrophages

14 erosis, and activation of antigen-specific T helper 1-type T cells is thought to fuel plaque inflamma

15 Here we report that the key T helper 17 (T(H)17) cell differentiation stimulator, STAT

16 Appropriate balance of T helper 17 (Th17) and regulatory T (Treg) cells maintains

17 SAA1 and SAA2 by the host, which increases T helper 17 (Th17) cell production.

18 Memory T helper 17 (Th17) cells (CD4(+)IL-17A(+)CD44(+)) drive th

19 ers of CD44(hi)IL-17(+)IFN-gamma(-) memory T-helper 17 (Th17) cells in the retina, cervical lymph nod

20 nt interleukin-17A (IL-17A) secretion from T helper 17 (Th17) cells of the lamina propria, followed b

21 T helper 17 (Th17) cells, an important subset of CD4(+) T

22 inflammation, particularly HIV-susceptible T-helper 17 (Th17) cells, are unknown.

23 CD4+ T helper 17 (Th17) cells, characterized by IL-17 productio

24 T helper 17 (Th17) cells, defined by RORgammat-dependent p

25 Type I interferon (IFN-I) and T helper 17 (TH17) drive pathology in neuromyelitis optica

26 r fungi, yet the reasons for this dominant T-helper 17 (Th17) response in PSC are not clear.

27 in mice and humans convincingly show that T-helper 17 (Th17)/interleukin 17 (IL-17)-driven immunity

28 develops under the influence of the IL-23/T helper 17 cell axis and is characterized by intense infl

29 The interleukin-23 (IL-23)/T-helper 17 cell pathway is implicated in psoriatic arthri

30 tina and a significantly reducing effector T helper 17 cells and inflammatory macrophages.

31 ng lymph nodes and decreases the number of T helper 17 cells, a pathogenic cell population in EAE.

32 ulates the expression of interleukin-17 in T helper 17 cells.

33 had higher infiltration of neutrophils and T helper 17 cells.

34 tored Treg function, suppressed pathogenic T helper 17 response, and significantly ameliorated the di

35 The activation of T helper 17 signaling plays a critical role in psoriasis p

36 and other RAbos were strong inhibitors of T helper-17 cell effector function in vitro, showing that

37 g growth factor-beta (TGF-beta) suppresses T helper 2 (T(H)2)-cell-mediated cancer immunity(9), we sh

38 y exists whether cDC1s also control CD4(+) T helper 2 (Th2) cell responses, since suppressive and act

39 es interleukin (IL)-4, IL-5 and IL-13 from T helper 2 (Th2) cells and innate lymphoid cells type 2 (I

40 phoid cells (ILC2s) are a potent source of T-helper 2 (Th2) cytokines that promote AHR and lung infla

41 hildhood that is characterized by dominant T-helper 2 cell activation without adequate counter-regula

42 parent discrepancies regarding the role of T helper 2 cells in atherosclerosis based on studies that

43 ed protective response is dependent on the T helper 2 cytokine interleukin-4 (IL-4), but not the T he

44 Third, T helper 2 immune responses are protective in children.

45 s was characterized by hypercytokinemia; a T helper 2 signature; recruitment of low HLA-DR expressing

46 urprisingly, eosinophilia, associated with T helper 2, may be protective.

47 migration to the dLN where they initiated T helper-2 cell differentiation.

48 ed that the IL22 was produced primarily by T-helper 22 cells.

49 erived costimulatory factors triggered their helper activity, defined by their ability to produce IFN

50 d by infectious cycling in the presence of a helper adenovirus to yield a new AAV variant that then s

51 ody production and dysregulated T follicular helper and B cell responses.

52 DC have the ability to activate both CD4(+) helper and CD8(+) cytotoxic T cells in response to necro

53 riptional analysis revealed a polyfunctional helper and cytotoxic phenotype characterized by the expr

54 In addition to helper and regulatory potential, CD4(+) T cells also acq

55 IgE levels, showing that Tfr cells have both helper and suppressor functions in IgE production in the

56 lucidation, and bioassays, we found that the helper bacteria inactivate tolaasin by linearizing the l

57 Yet, fungus-associated helper bacteria of the genus Mycetocola (Mycetocola tola

58 For these fungi, helper bacteria play an important role in the establishm

59 uld develop gradually, to reduce the risk of helpers being exploited.

60 ggested that this association occurs because helpers buffer the negative effects of adverse ecologica

61 establish whether the presence and number of helpers buffer the negative effects of variation in rain

62 spectrum of transcriptional signatures, with helper CD4(+) T cells and B cells being relatively diver

63 Induction of functional helper CD4(+) T cells is the hallmark of a protective im

64 Helper CD4(+) T-cell phenotype and function following HC

65 ns of cytotoxic T lymphocytes (CD8(+)) and T helper (CD4(+)) cells detected in tumor tissues.

66 e analyzed the B and T peripheral follicular helper cell (pTfh) responses.

67 Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in resp

68 ant mediator for the development of type 2 T-helper cell (Th2)-driven inflammatory disorders and has

69 pha receptor constant chain and changes in T helper cell 1, T helper cell 2, T helper cell 17, CD8+ e

70 anges in T helper cell 1, T helper cell 2, T helper cell 17, CD8+ effector, CD4+ memory, and regulato

71 models, dry eye disease is associated with T helper cell 17-mediated inflammation of the ocular surfa

72 tant chain and changes in T helper cell 1, T helper cell 2, T helper cell 17, CD8+ effector, CD4+ mem

73 uced a partial expansion of the T follicular helper cell compartment, essential for B cell memory res

74 T helper cell differentiation requires lineage-defining tr

75 cetylates NFkappaB-p65 at K310 to modulate T helper cell differentiation.

76 cell epitopes, impedes the presentation of T helper cell epitopes, and attracts mannose binding prote

77 ed signaling to the promotion of effective T helper cell immune responses, during both anti-fungal ho

78 ) mouse leads to a shift of the follicular T helper cell program from follicular T helper (Tfh)-IL-17

79 e demonstrate that the CoV-2-specific CD4+ T helper cell response is directed against all 3 proteins

80 (H)2 cell and, especially, IL-17-producing T helper cell responses, and promoting memory T cell diffe

81 associated with decreased antigen-specific T helper cell responses.

82 tial B-cell clonal composition, T-follicular helper cell signaling, increased rounds of productive so

83 CV-specific CD4+ T cells with a follicular T helper cell signature that is maintained after therapy-i

84 omoting disease) and a specific T follicular helper cell subset that contributes to IgG4 isotype swit

85 that leads to the development of a chronic T helper cell type 1-polarized systemic immune response ac

86 f T(H)1, T helper cell type 2 (T(H)2), and T helper cell type 17 (T(H)17), and of follicular-helper T

87 enriched for TLR (Toll-like receptor) and T-helper cell type 17 (Th17) signaling and endoplasmic ret

88 nd anti-inflammatory transcripts of T(H)1, T helper cell type 2 (T(H)2), and T helper cell type 17 (T

89 There was no reciprocal increase of T-helper cell type 2 (Th2) cytokine genes or the Th2 chemo

90 strain failed to induce the nonprotective T helper cell type 2 (Th2) responses characteristic of wil

91 IFN-gamma-type response than RV-A without T-helper cell type 2 (Th2) upregulation.

92 ith a high dose of T. muris that induces a T helper cell type 2-polarized immune response did not aff

93 anies atherosclerosis, autoreactive CD4(+) T-helper cells accumulate in the atherosclerotic plaque.

94 ncreased proportions of cytotoxic follicular helper cells and cytotoxic T helper (T(H)) cells (CD4-CT

95 ifferentiation signals, such as T follicular helper cells and follicular dendritic cells.

96 TT-specific, CD40 ligand-expressing CD4(+) T helper cells and maturation of antigen-presenting cells.

97 increase germinal center B and T follicular helper cells and plasma neutralizing antibodies.

98 required for the development of T follicular helper cells and T follicular regulatory (Tfr) cells tha

99 ior to treatment suggested that T follicular helper cells and various other immune cell subsets may p

100 promoted the differentiation of T follicular helper cells followed by an enhanced germinal center res

101 ly expand alloreactive IL-18R1+ T peripheral helper cells in allograft tissues to promote donor-speci

102 olific innate killers, NK cells are also key helper cells in antiviral defense, influencing adaptive

103 lular immune response of type-1 and type-2 T helper cells in rhesus macaques.

104 nscriptional characteristics of follicular T helper cells increasingly shaped the circulating HCV-spe

105 ignature associated with CD4(+) T follicular helper cells that is associated with longer progression-

106 mory B cells and a reduction in T follicular helper cells with a phenotype suggesting recent GC activ

107 dendritic cells (which activate T follicular helper cells) and lymphatic sinus-associated SIGNR1(+) m

108 pitopes that elicit CD8(+) T cells, CD4(+) T helper cells, and IgG2b antibodies, and (ii) adjuvant ac

109 r T cell populations, including T follicular helper cells, and increases germinal center B cells and

110 tion, PI3K in B lymphocytes, iCOS-iCOSL in T helper cells, and the role of NFAT in regulating the imm

111 ponse was predominantly mediated by type-1 T helper cells, as demonstrated by the profiling of the Ig

112 sed splenic CD3+ T cells, specifically CD4+T helper cells, compared to splenocytes from non-irradiate

113 germinal center formation, and T follicular helper cells, especially when the load of the antigen is

114 oduced mainly by Th17 cells and T follicular helper cells, has been intensively investigated in B cel

115 of this effector program become T follicular helper cells, supporting development of B cells expressi

116 of less T-central-memory cells, T-follicular-helper cells, TGF-beta response, and CD4( +) T memory re

117 ell maturation into CXCR5+PD-1+ T follicular helper cells.

118 features of recently described T peripheral helper cells.

119 o differentiate into CD16(-)/CD25(+)/CD83(+) helper cells.

120 a higher abundance of cytotoxic phenotype T helper cells.

121 levels in part by inhibition of T follicular helper cells.

122 dent cross-activation of myeloid cells and T helper cells.

123 lls and indirectly by promoting T follicular helper cells.

124 dependent on interactions with T follicular helper cells.

125 of circulating CXCR5(+)PD-1(+) T follicular helper (cT(FH)) and T follicular regulatory (T(FR)) cell

126 T cells revealed that IL-2(+) cells produce helper cytokines, and that IFN-gamma(+) cells produce cy

127 Induced Loops (RAIL), utilizes complementary helper DNA oligonucleotides that expose gaps or loops at

128 lex) that mediate cyclic cascade and role of helper enzymes.

129 splaying B41 trimers carrying a PADRE T-cell helper epitope (TCHE).

130 a B cell GAS peptide epitope, a universal T helper epitope, and a synthetic toll-like receptor 2-tar

131 Na-APR-1 from N americanus, attached to a T-helper epitope.

132 ion rates steadily decreased with increasing helper expression.

133 tase-A with RgE-tuned levels of the required helper factor SUMF1 demonstrated that the maximum specif

134 iNKT cells can serve both as helpers for effector B cells and negatively regulate aut

135 of peanut-specific IgE, revealing an active helper function by Tfr cells on Ag-specific IgE.

136 In this study, we explored the helper function of human NK cells in chronic HIV-1 infec

137 The helper function of Tfr cells for IgE production involves

138 ying integrated domains, suggesting a paired helper function.

139 t requires Microprocessor recognition of the helper hairpin and linkage of the two hairpins, yet pred

140 r, linker lengths, and the identities of the helper hairpin, the recipient hairpin, the linker-sequen

141 40-fold higher levels when clustered with a helper hairpin.

142 hairpins, yet predominantly manifests after helper-hairpin processing.

143 to that connecting Prochlorococcus with the 'helper' heterotrophic microbes in its environment.

144 eutrophils, instead inducing iNKT follicular helper (iNKTfh) cells that in turn promote autoimmunity.

145 onal regulator Id2, which defines the common helper-like innate lymphoid progenitor (ChILP), but not

146 ke 1, also known as ST2) in ILC2p and common helper-like innate lymphoid progenitors (CHILP), at leas

147 ch T cell subset function (such as effector, helper, memory or regulatory function) is dictated by di

148 We applied this method to NRC4-a helper NLR that functions with multiple sensor NLRs with

149 the context of networking with receptor and helper NLRs and downstream resistance machineries.

150 -coil (CC) HET-S and LOP-B (CC(HELO)) domain helper NLRs that is recruited by intracellular Toll-inte

151 nd N REQUIREMENT GENE 1 (NRG1), that act as "helper" NLRs during multiple sensor NLR-mediated immune

152 Experiments reveal optimal helper oligodeoxynucleotide designs and conditions for t

153 70 promoter for a heat-inducible transposase helper plasmid, and creating vectors marked with the D.

154 ties by altered transcription, co-chaperone "helper" proteins, and ATP binding and hydrolysis.

155 Peripheral T follicular helper (pTfh) responses to S or N strongly correlated wi

156 L vector had a blunting effect on CD4(+) Th1 helper responses and instead favored the induction of my

157 l responses for the former and CD4(+) T-cell helper responses for the latter.

158 In contrast, helper responses in chronic infection were infrequently

159 otoxicity) or class II (important for T-cell helper responses) genes, we analyzed GWAS from 24 case-c

160 fic, redundant, and synergistic functions of helper RNLs is limited.

161 hus reveal that Tfr cells have an unexpected helper role in promoting food allergy and may represent

162 eproductive divide with distinct breeder and helper roles.

163 n and maintenance of GCs, providing critical helper signals such as CD40L.

164 were phenotypically distinct from follicular helper T (T(FH)) cells and lacked BCL6 expression.

165 ), secreted by a subpopulation of follicular helper T (T(FH)) cells and T-B cell border-enriched fibr

166 Follicular helper T (T(FH)) cells are implicated in type 1 diabetes

167 lammatory effector T cells versus follicular helper T (T(FH)) cells that mediate high-affinity antibo

168 ds upon effective interactions of follicular helper T (T(fh)) cells with germinal center (GC) B cells

169 veloped as T helper 1 (T(H)1) and follicular helper T (T(FH)) transcriptomes contracted and partially

170 ock8(-/-) mice have a profound type 2 CD4(+) helper T (T(H)2) cell bias upon pulmonary infection with

171 CD4(+) effector T cells including follicular helper T (Tfh) cells are the major producers of TLR7-ind

172 e defects could be corrected when follicular helper T (Tfh) cells were induced before macrophage abla

173 ies, with increased activated T cells, naive helper T (Th) and cytotoxic T cells, loss of CD56bright

174 en (Ag)-presenting cells (APC) instruct CD4+ helper T (Th) cell responses, but it is unclear whether

175 In a murine model, Alp1 elicits helper T (Th) cell-dependent lung eosinophilia that is i

176 Type 1 helper T (Th1) cells and Type 17 helper T (Th17) cells i

177 Type 1 helper T (Th1) cells and Type 17 helper T (Th17) cells increased initially and promoted o

178 umulating evidence has shown that follicular helper T cell (T(FH)), a critical player in humoral immu

179 le to identify a super-functional follicular helper T cell (Tfh)-like subpopulation in lupus-prone NZ

180 We describe distinct helper T cell activation and migration profiles along th

181 Furthermore, we find an association between helper T cell content in thyroid tissue and a COMMD3/DNA

182 of key transcription factors in determining helper T cell identity.

183 elper T lymphocyte proportions and low naive helper T cell proportions are associated with those most

184 r T cells and naive CD3+ CD4+ CD62L+ CD45RA+ helper T cell subpopulation fractions were significantly

185 Treg-mediated suppression of host follicular helper T cell-dependent antibody production.

186 These include a defective interaction of helper T cells (CD4+) with B cells in germinal centers,

187 ty and gene connectivity in human follicular helper T cells (TFH), a cell type required for anti-nucl

188 Follicular helper T cells (Tfh), CD4 lymphocytes critical for effic

189 n model on the mouse, and detect whether the helper T cells (Th) and regulatory T cells (Treg) could

190 of their antigen receptor (TCR) by B cells, helper T cells act on B cells via CD40 ligand and secret

191 as T(H)2, T(H)9, T(H)17, T(H)22, follicular helper T cells and CD28(null) T cells, as well as other

192 nifestations and GATA2 deficiency, CD4+ CD3+ helper T cells and naive CD3+ CD4+ CD62L+ CD45RA+ helper

193 We detected reduced relative numbers of helper T cells and reduced activation of B cells in DLB

194 CD4(+) helper T cells contribute important functions to the imm

195 us, targeted TGF-beta signalling blockade in helper T cells elicits an effective tissue-level cancer

196 on of germinal center B cells and follicular helper T cells in the draining lymph node and Ag-specifi

197 ferentiation of naive CD4 T lymphocytes into helper T cells subtypes, including types 1, 2, and 17 he

198 cells to differentiate into pro-inflammatory helper T cells that are prone to invade into tissue and

199 These tonsillar CCR6(+)B helper T cells were phenotypically distinct from follicu

200 Follicular helper T cells were the primary source of IL-21 that inh

201 ne networks in the intestine associated with helper T cells' (Th1, Th2, and Th17) specific pathways.

202 rough liver-resident immunoregulatory CD4(+) helper T cells, alternatively activated macrophages, and

203 row-infiltrating OX40+ cytotoxic T cells and helper T cells, as well as decreased ICOS+ and 4-1BB+ na

204 cells subtypes, including types 1, 2, and 17 helper T cells, that have more tailored immunologic resp

205 ogate endogenous, Salmonella-specific CD4(+) helper T cells, we show that certain host microenvironme

206 er ICOS(+) populations, including peripheral helper T cells, were highly sensitive to costimulation b

207 haracterized population of extrafollicular B helper T cells, which produced IL-10 and could play a pr

208 per cell type 17 (T(H)17), and of follicular-helper T cells.

209 trong CD4 cytokine response involving type 1 helper T cells.

210 d steering their interaction with follicular helper T cells.

211 homeostasis, and differentiation into CD4(+) helper T lymphocyte (Th)17 cell phenotypes.

212 Low total helper T lymphocyte proportions and low naive helper T c

213 cently discovered population of T follicular helper T(fh)13 cells regulates the production of high-af

214 Vaccination induced type 1 helper T-cell (Th1)-biased CD4 T-cell responses and low

215 al specimens reveals a predominantly type 17 helper T-cell (Th17)/Th1 signature, implicating this as

216 Recent reports suggest helper T-cell abnormalities in minimal-change nephrotic

217 icate allergic disorders that show a similar helper T-cell profile with Th2/Th17 predominance.

218 regions, suggesting that both cytotoxic and helper T-cell responses are important.

219 marker to draw inferences about T follicular helper (T(FH)) activity within germinal center.

220 he distribution of T(H) cell and folliclular helper (T(FH)) cell subsets was analyzed by flow cytomet

221 tantly investigated the role of T follicular helper (T(FH)) cells and B cells during ABMR in 105 kidn

222 T follicular helper (T(FH)) cells are a distinct type of CD4(+) T cel

223 T follicular helper (T(FH)) cells are critical in adaptive immune res

224 e alter the functional state of T follicular helper (T(FH)) cells in vitro and in vivo, thereby exert

225 r and induced the maturation of T follicular helper (T(FH)) cells.

226 sful DAA treatment reconstitute T follicular helper (T(FH))-B cell axis in HCV patients is unclear.

227 of Ehrlichia muris that type 1 T follicular helper (T(FH1)) cells provide help to CD11c(+) T-bet(+)

228 onstrate a wholly novel mechanism by which T-helper (T(H) ) polarization is governed and provide crit

229 oxic follicular helper cells and cytotoxic T helper (T(H)) cells (CD4-CTLs) responding to SARS-CoV-2

230 natomical compartments, suppressing type 1 T helper (T(H)1) cell responses while permitting T(H)2 cel

231 ted T(reg) cells into the type 2 and type 17 helper (T(H)2 and T(H)17) effector T cells by Wnt and Hi

232 including T(H)1, T(H)2, T(H)9, T follicular helper, T follicular regulatory, and regulatory T cells.

233 ded double-negative, but depleted follicular helper, T-cell compartments and impaired Fas-dependent a

234 pecific SLE T-cells displayed a T-follicular helper-(T(FH))-like phenotype, with CXCR5/Bcl-6 and IL-2

235 lymphocyte interactions, drives T follicular helper (Tfh) cell development in germinal centers (GCs).

236 tly control naive B and cognate T follicular helper (Tfh) cell interaction and initiation of the GC r

237 nt SARS-CoV-2-specific GC B and T follicular helper (Tfh) cell responses as well as LLPCs and MBCs.

238 The current view is that CD4(+) T follicular helper (Tfh) cells are the main subset regulating autore

239 CD4+ T follicular helper (Tfh) cells dominate the acute response to a bloo

240 nut flour, naive mice developed T follicular helper (Tfh) cells in their lung draining lymph nodes an

241 T follicular helper (Tfh) cells play a very important role in mountin

242 Follicular T helper (TFH) cells provide B-cell help and are crucial f

243 CXCR5(+) T follicular helper (Tfh) cells provide help to B cells, are essentia

244 l center B cells, as well as to T follicular helper (TFH) cells, and directly regulates B cells and T

245 ls, IL-17-producing Th17 cells, follicular T helper (Tfh) cells, or regulatory T (Treg) cells.

246 roenvironment, including CD4(+) T follicular helper (Tfh) cells.

247 pediments, including defects in T follicular helper (Tfh) cells.

248 f lung dendritic cells (DCs) in T follicular helper (Tfh)-cell induction, a T-cell subset critically

249 ular T helper cell program from follicular T helper (Tfh)-IL-17 to Tfh-IFN-gamma.

250 tch murine transplant model and T follicular helper (Tfh):B cell co-culture system.

251 id organs, which expressed lower levels of T helper (Th) 1 and Th17 cytokines and higher levels of Th

252 The impact of T helper (Th) 1 versus Th2 immunity on intracellular infec

253 ch was associated in vivo with a decreased T helper (Th) 1/17 differentiation and Treg formation with

254 ates immunosuppression, and by a subset of T-helper (Th) 17-cells, where it limits pathogenicity.

255 nitis and food allergy, mainly by inducing T helper (Th) 2 immune responses and clinical trials with

256 nf-cDC2s) were superior in inducing CD4(+) T helper (Th) cell polarization while simultaneously prese

257 Inter-individual differences in T helper (Th) cell responses affect susceptibility to infe

258 ne system, NKG2D-driven regulation of CD4+ T helper (Th) cell-mediated immunity remains unclear.

259 T helper (Th) cells are CD4(+) effector T cells that play

260 The importance of CD4+ T helper (Th) cells is well appreciated in view of their e

261 system, namely effector choice among CD4+ T helper (Th) cells.

262 produce multiple functionally specialized T helper (Th) subsets.

263 Atopic dermatitis (AD) is a T helper (Th)2-biased disease with elevated expression of

264 Differentiation of T-helper (Th1) cells, Th2 cells, and T-regulatory cells wa

265 onal specialization of NLRs into sensors and helpers, the independent emergence of direct and indirec

266 products and lingonberry press cake (called "helpers") to minimize lipid oxidation during acid/alkali

267 his was achieved by creating a binary vector/helper transformation system by linking the hopper(Bd-we

268 n that drives the generation of pathogenic T-helper type 1 (T(H)1) cells with proinflammatory cytokin

269 Most participants had T helper type 1 (T(H)1)-skewed T cell immune responses wit

270 omplement C3 activity is integral to human T helper type 1 (Th1) and cytotoxic T cell responses.

271 ture of B cell enrichment, upregulation of T helper type 1 (Th1) and Th2 cell-associated pathways, in

272 ravated phenotype is mediated by increased T helper type 1 (Th1) cell polarization, which in turn res

273 children and is associated with nonatopic T-helper type 1 (Th1) cell polarized inflammation that cor

274 larization and interferon-gamma-expressing T-helper type 1 (Th1) cells but increases in interleukin 5

275 ral factors such as OAS1-3 and IFIT1-3 and T helper type 1 (Th1) chemokines CXCL9/10/11, as well as a

276 oid cells (ILCs) functionally analogous to T helper type 1 (Th1), Th2, and Th17 cells are well charac

277 the CD4(+) T cell effector program [e.g., T helper type 1 (Th1), Th2, Th17].

278 st innate immune regulator responsible for T helper type 1 and type 17 (Th1 and Th17) development and

279 antly, tofacitinib treatment did not alter T helper type 1 responses or parasite control.

280 diet analogous to the WD in mice leads to T helper type 1-/T helper type 17-biased skin inflammation

281 memory TNF-alpha and IL-17 double-positive T helper type 17 (Th17) cells is a leading feature of refr

282 Psoriasis is a T helper type 17 autoimmune disease associated with an inc

283 The IL-23/T helper type 17 cell axis is a target for psoriasis.

284 romote proliferation of memory T cells and T helper type 17 cells.

285 skin and joint disease without suppressing T helper type 17 cytokine expression.

286 o the WD in mice leads to T helper type 1-/T helper type 17-biased skin inflammation before significa

287 the mediastinal lymph nodes, and increased T-helper type 2 (T(H) 2)-cell differentiation.

288 following each bladder infection, a highly T helper type 2 (T(H)2)-skewed immune response directed at

289 Although T-helper type 2 (Th2) cell pathology is implicated in seve

290 Memory CD4+ T helper type 2 (Th2) cells drive allergic asthma, yet the

291 Cytokines produced by T-helper type 2 cells and transforming growth factor beta

292 of dermal C-C chemokine receptor type 4(+) T helper type 2 cells, IL-17(+) cells, basophils, substanc

293 d by several T-cell populations, including T-helper type 2 cells.

294 T cells from Valpha14(Tg) NC mice showed a T helper type-1-dominant cytokine profile, which may accou

295 is-affected tissues, the imbalance between T-helper type-17 (Th17) and T-regulatory (Treg) lymphocyte

296 he absence of AhR, we detected an enhanced T helper type-2 (Th2) [increased interleukin 5 (IL-5) and

297 in the liver, and possibly does not require helper virus coinfection.

298 ught animals that could serve as a potential helper virus.

299 Using helper viruses with cell type specific promoters to targ

300 ase chain reaction, and GCs and T follicular helper were assessed using immunohistochemistry.