ライフサイエンスコーパス: hemangioblastoma

1 pography, suggests a developmental origin of hemangioblastoma.

2 forme and is overexpressed in human cerebral hemangioblastoma.

3 rvival outcomes in patients with spinal cord hemangioblastoma.

4 erapy may be effective for retinal capillary hemangioblastomas.

5 lar tumors, including central nervous system hemangioblastomas.

6 specifically clear cell renal carcinomas and hemangioblastomas.

7 oradic renal cell carcinomas (RCC) and brain hemangioblastomas.

8 d with sporadic renal cell carcinoma and CNS hemangioblastomas.

9 renal carcinomas and central nervous system hemangioblastomas.

10 n Hippel-Lindau disease patients with 22 CNS hemangioblastomas (11 spinal cord; 11 cerebellar) that w

11 1 patients [77%]) and central nervous system hemangioblastomas (15 of 50 patients [30%]).

12 with important roles in the pathogenesis of hemangioblastoma and CC-RCC.

13 neoplasms, including central nervous system hemangioblastoma and clear cell renal cell carcinoma (CC

14 Loss of VHL expression predisposes to hemangioblastoma and clear cell renal cell carcinoma, wh

15 ations predisposing to renal cell carcinoma, hemangioblastoma and pheochromocytoma.

16 nificantly increased incidence of cerebellar hemangioblastoma and RCC (hazard ratios 2.3 and 4.0, res

17 that HIF deregulation plays a causal role in hemangioblastoma and renal carcinoma, and raises the pos

18 ight one day play a role in the treatment of hemangioblastoma and renal cell carcinoma.

19 A specific ELISA showed that hemangioblastomas and CC-RCCs expressed SDF-1alpha prote

20 In hemangioblastomas and CC-RCCs, HIF-1alpha is constitutiv

21 ha was detected in tumor cell nuclei of both hemangioblastomas and CC-RCCs.

22 within tumor cells and endothelial cells of hemangioblastomas and CC-RCCs.

23 l cell-derived factor-1alpha (SDF-1alpha) in hemangioblastomas and CC-RCCs.

24 The genetic hallmark of hemangioblastomas and clear cell-renal cell carcinomas (

25 e been linked to the development of sporadic hemangioblastomas and clear-cell renal carcinomas.

26 Despite their benign pathology, hemangioblastomas and ELSTs are a frequent cause of morb

27 lar pathobiology and clinical course between hemangioblastomas and ELSTs, the optimal management stra

28 the tumor cell of origin for VHL-associated hemangioblastomas and indicate that it is also the proge

29 s, seven lipid-poor angiomyolipomas, and one hemangioblastoma) and 68 malignant masses (including 41

30 ma, pheochromocytoma/paraganglioma, cerebral hemangioblastoma, and endolymphatic sac tumors.

31 , ectopia lentis, neurofibromatosis, retinal hemangioblastomas, and familial exudative vitreoretinopa

32 ch predisposes individuals to kidney cancer, hemangioblastomas, and paragangliomas.

33 ssor gene predispose people to renal cancer, hemangioblastomas, and pheochromocytomas in an allele-sp

34 would predict that children who present with hemangioblastoma are likely to harbor germline mutation

35 ures and blood vessels within VHL-associated hemangioblastomas are a result of tumor-derived vasculog

36 Hemangioblastomas are central nervous system (CNS) tumor

37 Hemangioblastomas are composed of neoplastic "stromal" c

38 Spinal cord hemangioblastomas are rare, benign, intradural tumors th

39 kD complex was selectively downregulated in hemangioblastoma as compared to glioblastoma multiforme.

40 Hemangioblastoma-associated cyst wall histomorphological

41 wly and progressively evolved into enlarging hemangioblastoma-associated cysts in all tumors (mean fo

42 uld be evaluated in 12 patients with retinal hemangioblastomas at baseline, all (100%) were graded as

43 angiomesenchymal tumorlets, which resembled hemangioblastoma, but which also consistently showed dis

44 r include retinal and central nervous system hemangioblastomas, clear cell renal carcinomas and pheoc

45 hich is associated with an increased risk of hemangioblastomas, clear cell renal cell carcinomas (ccR

46 Thirteen (59%) hemangioblastoma-cysts became symptomatic (mean time to

47 riety of autocrine loops may be initiated in hemangioblastomas, depending on the differentiation stat

48 Four children with solitary hemangioblastoma did not have a detectable germline dele

49 creened 6 pediatric patients with cerebellar hemangioblastoma for germline or somatic mutations of th

50 alysed two renal cell carcinomas and one CNS hemangioblastoma from three unrelated patients for genet

51 ing, we analyzed five central nervous system hemangioblastomas from three patients of a single VHL ge

52 All 10 hemangioblastomas had a mean area reduction of 15% or mo

53 Individuals with ocular hemangioblastomas had a significantly increased incidenc

54 nset renal cell carcinoma and </= 40% of CNS hemangioblastoma harbor germline VHL mutations without a

55 ents develop multiple central nervous system hemangioblastomas (HB).

56 variety of tumor types that include retinal hemangioblastomas, hemangioblastomas of the central nerv

57 To better understand hemangioblastoma histogenesis, we analyzed postmortem CN

58 Solitary cerebellar hemangioblastoma in children does not predict a germline

59 The tumorigenesis of hemangioblastoma in younger patients may differ from tha

60 4, 12 had 1 or more evaluable active retinal hemangioblastomas in 16 eyes at baseline per independent

61 Eighteen retinal hemangioblastomas in 17 eyes were treated with PDT.

62 Among this subgroup, 10 of 24 hemangioblastomas in 8 eyes of 6 participants measured 5

63 distribution of central nervous system (CNS) hemangioblastomas in the von Hippel-Lindau (VHL) tumor s

64 Exophytic juxtapapillary retinal capillary hemangioblastoma (JRCH) can be difficult to diagnose.

65 eveloping central nervous system and retinal hemangioblastomas, kidney cysts and clear cell carcinoma

66 derstanding the factors underlying growth in hemangioblastoma may lead to better strategies to arrest

67 er, recent data indicate that VHL-associated hemangioblastoma neoplastic cells originate from embryol

68 nt with unresectable symptomatic suprasellar hemangioblastoma, octreotide resulted in tumor volume re

69 ons result in organ-specific tumors, such as hemangioblastoma of the central nervous system and renal

70 ypes that include retinal hemangioblastomas, hemangioblastomas of the central nervous system, renal c

71 inically by vascular tumors including benign hemangioblastomas of the cerebellum, spine, brain stem a

72 elopment of highly vascular tumors including hemangioblastomas of the retina and central nervous syst

73 No new retinal hemangioblastomas or ocular disease progression were rep

74 redisposition to renal clear-cell carcinoma, hemangioblastoma, pheochromocytoma, and autosomal-recess

75 e at high risk of multiple tumors (e.g., CNS hemangioblastomas, pheochromocytoma, and renal cell carc

76 including retinal and central nervous system hemangioblastomas, pheochromocytomas, and renal and panc

77 ained in von Hippel-Lindau disease patients, hemangioblastomas provide an opportunity to examine the

78 r both juxtapapillary and peripheral retinal hemangioblastomas, providing satisfactory rates of tumor

79 In 5 VHL patients, we resected quiescent hemangioblastomas (Q-HB) that were en-route during surgi

80 of advanced juxtapapillary retinal capillary hemangioblastomas (RCH) associated with von Hippel-Linda

81 tumor populations, their role in spinal cord hemangioblastoma remains poorly understood.

82 romocytoma, polycythemia, or combinations of hemangioblastoma, renal cell carcinoma, and/or pheochrom

83 Spinocerebellar hemangioblastomas, renal carcinomas, and pheochromocytom

84 ncer syndrome predisposing to ocular and CNS hemangioblastomas, renal-cell carcinoma (RCC), and pheoc

85 Moreover, in two patients who each had two hemangioblastomas resected each tumor contained a unique

86 It is characterized by brain and spinal-cord hemangioblastomas, retinal angiomas, clear-cell renal ca

87 rafamilial phenotypic variability of retinal hemangioblastoma (RH) in families with von Hippel-Lindau

88 Retinal Hemangioblastoma (RH) is the most frequent manifestation

89 ny patient with single or multifocal retinal hemangioblastomas (RHs), should undergo genetic testing

90 -route during surgical access to symptomatic hemangioblastomas (S-HB), for matched tumor analysis.

91 Retinal angiomas, cerebellar and spinal hemangioblastomas, solid organ cysts, and renal carcinom

92 Central nervous system lesions include hemangioblastomas (the most common tumor in VHL) and end

93 medical records of 17 patients with retinal hemangioblastoma treated with PDT were reviewed, and tre

94 Von Hippel-Lindau (VHL)-associated hemangioblastomas (VHL-HB) arise in the central nervous

95 Efficacy of belzutifan in retinal hemangioblastomas was a secondary end point, measured as

96 rigin of tumor vasculature in VHL-associated hemangioblastomas, we analyzed the vascular elements in

97 Further, similar to hemangioblastomas, we demonstrate that other VHL-associa

98 total of 716 adult patients with spinal cord hemangioblastoma were analyzed, with the majority being

99 VHL patients with at least 1 measurable hemangioblastoma were eligible.

100 Patients diagnosed with spinal cord hemangioblastoma were identified from the National Cance

101 sease, including capacity to control retinal hemangioblastomas, with effects sustained for more than

102 characteristic topographical distribution of hemangioblastomas within the CNS.

103 h null VHL alleles develop kidney cancer and hemangioblastomas without a high risk of paraganglioma.