ライフサイエンスコーパス: hemangioma

1 (rhabdomyoma, myxoma, teratoma, fibroma, and hemangioma).

2 eins (metastasis) and disrupts blood supply (hemangiomas).

3 treatment method for circumscribed choroidal hemangioma.

4 etina corresponding to the cavernous retinal hemangioma.

5 y for 6 months in the treatment of infantile hemangioma.

6 esion which had a classic imaging pattern of hemangioma.

7 nly confronted with the problem of a growing hemangioma.

8 re treated for symptomatic papillary retinal hemangioma.

9 or cellular growth and survival of infantile hemangioma.

10 system was searched in a 10-year period for hemangioma.

11 r-D is a target of itraconazole in infantile hemangioma.

12 valuation and treatment of CMN and infantile hemangioma.

13 ticipants had a clinically visible choroidal hemangioma.

14 46 were classified as benign foci other than hemangioma.

15 onchopulmonary aspergillosis, and subglottic hemangioma.

16 ure standard-of-care treatment for infantile hemangioma.

17 stemic use of propranolol to treat infantile hemangioma.

18 atments for periocular infantile (capillary) hemangioma.

19 ve been used to successfully treat infantile hemangioma.

20 l of stem cells derived from human infantile hemangioma.

21 osin, immunodiagnostic markers for infantile hemangioma.

22 port wine stain and in the diffuse choroidal hemangioma.

23 ker that is first line therapy for infantile hemangioma.

24 depicts the looping course of iris racemose hemangioma.

25 bnormal vessel growth typical of epithelioid hemangioma.

26 To describe OCTA features of iris racemose hemangioma.

27 rovessel associated with a retinal cavernous hemangioma.

28 th is a rare and atypical feature of hepatic hemangioma.

29 ations as the underlying cause of congenital hemangioma.

30 om patients undergoing resection for hepatic hemangioma.

31 a hemangiomatosis presentation of congenital hemangioma.

32 ations, juvenile angiofibromas and infantile hemangiomas.

33 of MET and contribute to the development of hemangiomas.

34 Weber syndrome [SWS]) and solitary choroidal hemangiomas.

35 data describe the natural history of hepatic hemangiomas.

36 nevi, nevus sebaceus, port-wine stains, and hemangiomas.

37 ful tool in the assessment of possible liver hemangiomas.

38 of benign vascular tumors such as infantile hemangiomas.

39 the treatment of certain types of infantile hemangiomas.

40 y for the treatment of complicated infantile hemangiomas.

41 mangiomas and treating complicated infantile hemangiomas.

42 on of propranolol on regression of infantile hemangiomas.

43 the formation and rapid growth of infantile hemangiomas.

44 (IGFBP3) was down-regulated in proliferating hemangiomas.

45 ular tumorigenesis in a mouse model of liver hemangiomas.

46 blockers to promote regression of periocular hemangiomas.

47 anscription factors Snail/Slug in involuting hemangiomas.

48 epartment as either typical or suspicious of hemangioma 1.5-4 years earlier were enrolled in this ret

49 hree types of liver lesions (13 cysts, seven hemangiomas, 10 metastases) were selected.

50 ad focal nodular hyperplasia, 25 (17.0%) had hemangiomas, 11 (7.5%) had hepatic epithelioid hemangioe

51 USG findings were categorized as (1) cyst or hemangioma, (2) indeterminate lesion, (3) suspicious for

52 lipoma (5%), lymphangioma (3%) and capillary hemangioma (3%).

53 17 patients with eyelid infantile capillary hemangiomas, 3 were excluded for asthma and 14 (7 males,

54 ses, 7 basal cell carcinomas, 7 melanomas, 4 hemangiomas, 4 dermatofibromas, 2 squamous cell carcinom

55 dded (FFPE) congenital cutaneous and hepatic hemangiomas, 4/8 had GNAQ or GNA11 Glu209 variants.

56 ecimens of venous malformations, 4 capillary hemangiomas, 7 lymphatic malformations, and 6 lymphatico

57 The most common diagnosis was cavernous hemangioma (72.7%) followed by orbital sheet meningioma

58 : To describe the sequelae left by infantile hemangiomas after natural involution and to identify cli

59 (RPE), hemorrhagic RPE detachment, choroidal hemangioma, age-related macular degeneration, RPE hyperp

60 mutations occur in both diffuse and solitary hemangiomas, although at distinct codons.

61 has been used to treat complicated infantile hemangiomas, although data from randomized, controlled t

62 Of the 13 lesions identified as a cyst/hemangioma and 17 as indeterminate, 1 was found to be me

63 n Tsc1+/- female mice, with 91% having liver hemangioma and 55% having severe lesions by 7 months of

64 tem cell as the cellular origin of infantile hemangioma and describes for what we believe is the firs

65 viously described in vivo model of infantile hemangioma and in cultured hemangioma-derived cells.

66 patient-derived in vitro model of infantile hemangioma and pre-clinical model of HLTRS we demonstrat

67 e lesions are shared with those of infantile hemangioma and tufted angioma of children, but features

68 difference in accumulation of RBCs between a hemangioma and uninvolved liver remains unknown.

69 d in 100% (6 of 6) of the solitary choroidal hemangiomas and (c.626A > C; p.Gln209Pro) in the choroid

70 riasis, use of topical timolol for infantile hemangiomas and bone marrow transplantation for dystroph

71 is the association of large segmental facial hemangiomas and congenital anomalies, such as posterior

72 for atopic dermatitis, psoriasis, infantile hemangiomas and dystrophic epidermolysis bullosa are rev

73 t of atopic dermatitis, psoriasis, infantile hemangiomas and dystrophic epidermolysis bullosa will be

74 e quotients of accumulation of Tc-99m-RBC in hemangiomas and in normal liver parenchyma (HEM/liv), an

75 nd show that FoxOs suppress the formation of hemangiomas and lymphomas in mice.

76 ALV-J) is a simple retrovirus that can cause hemangiomas and myeloid tumors in chickens and is curren

77 ells of the myeloid lineage in proliferating hemangiomas and propose a mechanism for the observed evo

78 Nine hemangiomas and six venous malformations were found amon

79 ndrome (BRRS), characterized by lipomatosis, hemangiomas and speckled penis.

80 ssed the development of VHL-associated liver hemangiomas and that angiogenic gene expression in hepat

81 clinical syndromes associated with infantile hemangiomas and treating complicated infantile hemangiom

82 33(-)/Ulex europeus-I(+)) from proliferating hemangiomas and used a previously described property of

83 Atypical presentation and abscess-, hemangioma-, and metastasis-like images delayed AE diagn

84 l retinal macrovessels and retinal cavernous hemangioma are benign lesions.

85 e-related macular degeneration and infantile hemangioma are more common in light-skinned individuals

86 Infantile hemangiomas are benign tumors of vascular endothelial ce

87 Infantile hemangiomas are characterized by rapid capillary growth

88 While hemangiomas are classic examples of angiogenesis, the an

89 genital melanocytic nevi (CMN) and infantile hemangiomas are commonly encountered in newborns and may

90 Infantile hemangiomas are composed of endothelial cells (ECs), end

91 Infantile hemangiomas are localized and rapidly growing regions of

92 Although capillary hemangiomas are more common in children, lobular capilla

93 esis, the angiogenic factors responsible for hemangiomas are not fully understood.

94 Our results indicate that hemangiomas are not microchimeric in origin.

95 Hemangiomas are one of the common primary benign tumors

96 As infantile hemangiomas are reported to express high levels of beta

97 Infantile hemangiomas are the most common benign tumors of infancy

98 Hemangiomas are the most common type of tumor in infants

99 Congenital hemangiomas are typically solitary and have not been rep

100 Congenital hemangiomas are uncommon benign vascular tumors that pre

101 isolated from blood or from a proliferating hemangioma, are stimulated by an angiogenesis inhibitor.

102 We hypothesized that congenital hemangiomas arise due to somatic mutation and performed

103 ls (PHACE syndrome--Posterior fossa defects, Hemangiomas, Arterial anomalies, Cardiac defects and Coa

104 diagnosed with periocular lobular capillary hemangioma at a median age of 39 years (range, 17-82 yea

105 All patients with eyelid infantile capillary hemangiomas at risk of developing amblyopia seen between

106 Vertebral hemangiomas being the most common of all are seen in dai

107 ioma of infancy and, using a murine model of hemangioma, bEnd.3 cells; we show that bEnd.3 hemangioma

108 s that Rapamycin also leads to regression of hemangioma blood vessels, consistent with its known anti

109 essed in the endothelium of human tumors and hemangiomas but was undetectable in normal endothelium.

110 teroids are commonly used to treat infantile hemangioma, but the mechanism of action of this therapy

111 e more common in children, lobular capillary hemangiomas can also arise in the periocular region of a

112 irths, and although rarely life threatening, hemangiomas can pose serious concerns to the cosmetic an

113 Although benign, some hemangiomas cause deformation and destruction of feature

114 apoptosis of the endothelial cells of mouse hemangioma cell line and infantile primary hemangioma en

115 s this issue, we used tie-2-deficient bEnd.3 hemangioma cells, which, surprisingly, were fully profic

116 Cavernous hemangiomas (CHs) account for 5% to 12% of all spinal va

117 Congenital hemangiomas (CHs) are rare benign vascular tumors that d

118 The average age at which hemangioma completed involution was 3.5 years.

119 An R183 codon is mutant in diffuse choroidal hemangiomas, consistent with other Sturge-Weber vascular

120 (OCTA) allows visualization of iris racemose hemangioma course and its relation to the normal iris mi

121 The diffuse choroidal hemangioma (DCH) was characterized by loss of the choroi

122 dition characterized by thymic lymphomas and hemangiomas, demonstrating that the mammalian FoxOs are

123 pression of GFP was used to confirm that the hemangioma-derived cells formed the blood vessels and ad

124 when transplanted into immunodeficient mice, hemangioma-derived cells recapitulated the unique evolut

125 odel of infantile hemangioma and in cultured hemangioma-derived cells.

126 and used a previously described property of hemangioma-derived ECs (HemECs), enhanced migratory acti

127 gioma-derived stem cells in vitro but not by hemangioma-derived endothelial cells or human umbilical-

128 In hemangioma-derived endothelial cells, defects in a vascu

129 Our hypothesis is that hemangioma-derived EPCs (HemEPCs) differentiate into the

130 ioma-genesis we characterized the progenitor hemangioma-derived stem cell (HemSC) and its lineage and

131 on its ability to inhibit proliferation of a hemangioma-derived stem cell population, human vasculoge

132 We also tested hemangioma-derived stem cells for expression of vascular

133 We tested hemangioma-derived stem cells for vasculogenic activity

134 Pretreatment of hemangioma-derived stem cells in vitro before implantati

135 examethasone suppressed VEGF-A production by hemangioma-derived stem cells in vitro but not by hemang

136 Silencing VEGF-A in hemangioma-derived stem cells reduced vasculogenesis in

137 d also inhibited the expression of VEGF-A by hemangioma-derived stem cells, and silencing of VEGF-A e

138 nt suppressed other proangiogenic factors in hemangioma-derived stem cells, including urokinase plasm

139 redefining the clinical course of infantile hemangiomas, describing clinical syndromes associated wi

140 is known about the pathogenesis of infantile hemangiomas despite the fact that they are relatively co

141 logic means, suggesting that angiogenesis in hemangiomas differs fundamentally from that of malignant

142 Although most CMN and infantile hemangiomas do not require active intervention, understa

143 zole also remarkably reduced angiogenesis of hemangioma endothelial cell in vitro.

144 nscriptome profiling via mRNA microarrays in hemangioma endothelial cell upon itraconazole treatment,

145 e hemangioma cell line and infantile primary hemangioma endothelial cell.

146 ry as a basis, we set out to explore whether hemangioma endothelial cells (HEC) were maternal in orig

147 thelial growth factor receptor-1 (VEGFR1) in hemangioma endothelial cells (hemECs) and hemangioma tis

148 As a consequence, hemangioma endothelial cells exhibit constitutive vascul

149 Cultured proliferating and involuting hemangioma endothelial cells were treated with varying c

150 led to a dose dependent cytotoxic effect in hemangioma endothelial cells with decreased cell viabili

151 32, CD14, CD15) that unexpectedly co-labeled hemangioma endothelial cells, providing new evidence tha

152 eningiomas, lipomas, vascular malformations, hemangiomas, epidermoid cysts, cerebellar astrocytomas,

153 tal cavernous venous malformations (not true hemangiomas), except that their vascular walls are thinn

154 Infantile hepatic hemangiomas exhibit a diverse phenotype.

155 s support a unifying diagnosis of congenital hemangioma for these vascular tumors.

156 es recent studies of molecular mechanisms of hemangioma formation and places new findings and hypothe

157 therapy for problematic hemangioma, to block hemangioma formation in vivo.

158 ngioma specimens, raise the possibility that hemangioma formation involves a combination of germline

159 uld be potentially helpful in distinguishing hemangiomas from other RBC-accumulating liver masses.

160 To understand the process of hemangioma-genesis we characterized the progenitor heman

161 During follow-up, 39.3% of hemangiomas grew 5% or more in mean linear dimension.

162 Nearly 40% of hepatic hemangiomas grow over time.

163 establishes Nox4 as a critical regulator of hemangioma growth and identifies fulvenes as a potential

164 Nox activity in vitro and potently inhibited hemangioma growth in vivo.

165 reased Ang2 mRNA levels and greatly impaired hemangioma growth in vivo.

166 th a soluble tie-2 receptor decreases bEnd.3 hemangioma growth in vivo.

167 that this treatment nearly abolished bEnd.3 hemangioma growth in vivo.

168 d subcutaneously into nude mice, we compared hemangioma growth originating from bEnd cells derived fr

169 on at a time when the treatment paradigm for hemangiomas has changed.

170 Hemangiomas have been found to be clonal neoplasms of en

171 By contrast, solitary choroidal hemangiomas have mutations in the Q209 codon, similar to

172 macrophage-treated ECs isolated from patient hemangiomas (HemECs) but not untreated HemECs readily di

173 ography performed in 1 eye depicted the iris hemangioma; however, small-caliber radial iris vessels w

174 nt, can clinically improve or cure infantile hemangioma; however, the underlying molecular mechanisms

175 ay) in the treatment of periocular infantile hemangioma (IH) based on clinical and radiological findi

176 Infantile hemangioma (IH) is a common childhood vascular tumor.

177 Infantile hemangioma (IH) is the most common tumor of infancy.

178 Herein, we used infantile hemangioma (IH), the most common tumor of infancy, as a

179 re multipotent cells isolated from infantile hemangioma (IH), which form hemangioma-like lesions when

180 Infantile hemangiomas (IH) are common tumors for which there is no

181 Propranolol therapy for infantile hemangiomas (IH) is now being used widely, and case repo

182 Infantile hemangiomas (IHs) are common benign tumors of infancy th

183 Infantile hemangiomas (IHs) are the most common benign tumors in e

184 ikely to make a correct diagnosis of SCC and hemangioma in color (P < .001 for both comparisons) and

185 Management of choroidal hemangioma in the PDT era has allowed for significantly

186 icantly accelerated the development of liver hemangioma in Tsc1+/- female mice, with 91% having liver

187 s tumors that are accompanied by soft tissue hemangiomas in Maffucci syndrome.

188 lar tumors that differ from common infantile hemangiomas in that they grow in utero and are fully dev

189 ly expressed in proliferating and involuting hemangiomas in vivo will contribute to our understanding

190 tion may be useful in the treatment of human hemangiomas in vivo.

191 reason for vertebroplasty was the vertebral hemangioma, in another 4 - pathological vertebral fractu

192 Using an experimental model of human hemangiomas, in which polyoma middle T-transformed brain

193 Conventional treatments for infantile hemangioma include the use of corticosteroids, laser, su

194 Certain clinical characteristics of hemangioma, including those located on the head and neck

195 The mechanisms that trigger involution of hemangioma into fibro-fatty tissue remain unknown.

196 Importance: Infantile hemangiomas involute to some extent, but they often leav

197 Capillary hemangiomas involved the upper eyelid in 10 cases and th

198 Infantile hemangioma is a benign endothelial tumor composed of dis

199 Infantile hemangioma is a common vascular tumor with a unique life

200 Epithelioid hemangioma is a locally aggressive vascular neoplasm, fo

201 Congenital hemangioma is a rare vascular tumor that forms in utero.

202 Synovial hemangioma is benign tumor of the joints and is seen rel

203 er proton beam therapy for retinal papillary hemangioma is convincing, whereas functional outcome may

204 male patient with the diagnosis of synovial hemangioma is reported and its radiologic findings are m

205 Infantile hemangioma is the most common benign vascular tumor of i

206 od cells (Tc-99m-RBC) for detection of liver hemangiomas is very high, it is still not perfect.

207 s malformation (VVM), also called "verrucous hemangioma," is a non-hereditary, congenital, vascular a

208 zed the treatment of proliferating infantile hemangiomas, laser and/or surgical excision are useful i

209 omas (KHEs), and childhood lobular capillary hemangiomas (LCHs).

210 l propranolol for eyelid infantile capillary hemangiomas led to complete regression of the lesion in

211 Superficial and deep hemangiomas left significantly fewer sequelae than combi

212 lls from hemangioma tissue that give rise to hemangioma-like lesions in immunodeficient mice.

213 d from infantile hemangioma (IH), which form hemangioma-like lesions when injected subcutaneously int

214 edominantly benign complication in infantile hemangioma, little is known about the prognosis of ulcer

215 most common lesions were renal cysts, liver hemangiomas, liver cysts, thyroid nodules, and uterine l

216 Comparison of hemangioma managed in the pre-PDT (1967-2001) era versus

217 t significantly fewer sequelae than combined hemangiomas (Mann-Whitney; superficial vs deep, OR, 1.6;

218 sically located inside the liver parenchyma, hemangiomas may occasionally develop outside the extra-h

219 Our in vitro and in vivo (hemangioma model of angiogenesis) experiments confirmed

220 Initial misdiagnosis as retinitis (n = 5), hemangioma (n = 1), choroidal neovascular membrane (n =

221 bdomyoma (n = 14), malignant tumor (n = 12), hemangioma (n = 9), thrombus (n = 4), myxoma (n = 3), te

222 ation on surgical specimens of proliferating hemangiomas (n=8) demonstrated no XX-labeled HEC from re

223 stabilizes (i.e., non-involuting congenital hemangioma [NICH]).

224 by Harve Deramond in France in 1984 due to a hemangioma of cervical vertebral body.

225 n of the endothelial tie-2 receptor in human hemangioma of infancy and, using a murine model of heman

226 Hemangioma of infancy is the most common neoplasm of chi

227 Hemangioma of the rib is rarely seen.

228 rteriovenous malformations: one had a benign hemangioma of the small bowel, and the other had chronic

229 Hemangiomas of infancy differ from malignant endothelial

230 found to be effective in treatment of severe hemangiomas of infancy.

231 Features of iris racemose hemangioma on OCTA.

232 center evaluating the growth rate of hepatic hemangiomas on cross-sectional imaging studies during a

233 These conditions include renal hemangiomas or arteriovenous malformations, ureteropelvi

234 or nearly complete resolution of the target hemangioma) or failure of trial treatment at week 24, as

235 d in children with associated skin capillary hemangioma (p < 0001).

236 wth factor receptor/integrin complex in some hemangioma patients, and somatic mutations in a phosphat

237 emangioma, bEnd.3 cells; we show that bEnd.3 hemangiomas produce both angiopoietin-2 (ang-2) and its

238 ic C482R VEGFR-2 mutant, linked to infantile hemangioma, promotes ligand-independent signaling by mim

239 ities of the airway, such as laryngomalacia, hemangiomas, pyriform aperture stenosis, choanal atresia

240 s/caregivers completed the 35-item Infantile Hemangioma Quality-of-Life (IH-QoL) instrument and provi

241 induced by M1 macrophages promotes infantile hemangioma regression and may lead to novel therapeutic

242 n part, recapitulated the natural history of hemangioma regression.

243 o-mesenchymal transition (EndMT) and promote hemangioma regression.

244 A proportion of infantile hepatic hemangiomas remain asymptomatic permitting observation u

245 5 months of age with proliferating infantile hemangioma requiring systemic therapy.

246 s of ulcerated rapidly involuting congenital hemangiomas (RICH) that were complicated by life-threate

247 quickly (i.e., rapidly involuting congenital hemangioma [RICH]) or partially regresses and stabilizes

248 Human placenta and infantile hemangioma samples highly express ECSCR protein, suggest

249 and ocular adnexal tissue, such as lymphoma, hemangioma, sarcoidosis, and dermoid cyst.

250 Spindle cell hemangioma (SCH) is a rare, benign vascular tumor of the

251 rmine how patients with more rapidly growing hemangiomas should be treated.

252 eformations helped to the final diagnosis of hemangioma, showing its origin from the liver edge.

253 VEGF-A was detected in hemangioma specimens in the proliferating phase but not

254 matic mutations in a phosphatase in sporadic hemangioma specimens, raise the possibility that hemangi

255 Hemangioma stem cells (HemSCs) are multipotent cells iso

256 ng of blood flow through vessels formed with hemangioma stem cells shows that Rapamycin also leads to

257 differentiation potential in patient-derived hemangioma stem cells, and suggests a novel therapeutic

258 cin reduces the self-renewal capacity of the hemangioma stem cells, diminishes differentiation potent

259 egrations in the MET gene in two of the five hemangiomas studied.

260 ary outcomes include the fraction of hepatic hemangiomas that demonstrated growth during long-term fo

261 Although the overall rate of growth is slow, hemangiomas that exhibit growth do so at a modest rate (

262 ve cohort study of images from 187 infantile hemangiomas that had not received systemic treatment and

263 Most are benign infantile hemangiomas that typically regress by 5 years of age; ot

264 Patients with hepatic hemangiomas that were 1 cm or larger as seen on cross-se

265 e clinical benefit of propranolol therapy in hemangioma, the mechanistic understanding of what drives

266 s a wide variety of human diseases,including hemangiomas, the most common tumor of childhood.

267 mature human placental vessels and infantile hemangiomas, the most common tumor of infancy and ECs.

268 apitulated the unique evolution of infantile hemangioma--the formation of blood vessels followed by i

269 be clinically and radiologically typical for hemangiomas, their HEM/liv ratios were at least 1.6 (sma

270 ropranolol exerts its suppressive effects on hemangiomas through the HIF-1alpha-VEGF-A angiogenesis a

271 in hemangioma endothelial cells (hemECs) and hemangioma tissue is markedly reduced compared to contro

272 isolation of multipotential stem cells from hemangioma tissue that give rise to hemangioma-like lesi

273 of vessels from proliferating and involuting hemangiomas to identify differentially expressed genes.

274 the current standard therapy for problematic hemangioma, to block hemangioma formation in vivo.

275 Patients with circumscribed choroidal hemangioma treated with PDT were identified, and factors

276 these or similar agents may be effective in hemangioma treatment.

277 shown a promising new therapy for infantile hemangioma using nonselective beta-blockers, including o

278 By OCTA, the hemangioma was clearly visualized as a uniform large-cal

279 rovessel associated with a retinal cavernous hemangioma was made.

280 By anterior segment OCT, the racemose hemangioma was partially visualized in all cases.

281 cidental diagnosis of a pedunculated hepatic hemangioma was strongly suggested by the typical imaging

282 In a subset of individuals with hemangioma, we found missense mutations in the genes enc

283 Using an experimental mouse model of human hemangioma, we found that the endothelial neoplasms deri

284 ents diagnosed with unilateral iris racemose hemangioma were included in the study.

285 of 4 patients with unilateral iris racemose hemangioma were included in the study.

286 of 79 patients with circumscribed choroidal hemangioma were treated with PDT.

287 Hemangiomas were avoided and only normal, pericyte-cover

288 e to normal placental vessels, proliferating hemangiomas were characterized by increased expression o

289 Involuting hemangiomas were characterized by the expression of chro

290 A total of 163 hemangiomas were identified in 123 patients.

291 Results: A total of 184 hemangiomas were included.

292 ism and amblyopia associated with periocular hemangiomas while minimizing side effects.

293 architecture of slow-growing Ang2-expressing hemangiomas, while Ang2+/- cells were greatly impaired i

294 indicates the rare association of congenital hemangioma with hematologic abnormalities and verifies s

295 cular haemangioma or an intermediate type of hemangioma with intra- and extraarticular components.

296 omatic exudative retinal papillary capillary hemangioma with or without association with von Hippel-L

297 Superficial hemangiomas with a cobblestone appearance or rough surfa

298 Hemangiomas with a step or abrupt border of the superfic

299 Using multivariate analysis, combined hemangiomas with a superficial component and a step bord

300 the chickens developed myeloid leukosis and hemangiomas within 2 months after hatching.

301 All eyes had sectoral iris racemose hemangioma without associated iris or ciliary body solid