ライフサイエンスコーパス: hematopoietic system

1 ney emerges as an important regulator of the hematopoietic system.

2 l for the development and homeostasis of the hematopoietic system.

3 sis, and leads to the formation of the adult hematopoietic system.

4 ol of stem and progenitor cells in the fetal hematopoietic system.

5 unodeficient mice reconstituted with a human hematopoietic system.

6 disease that disrupts normal function of the hematopoietic system.

7 tor cells of the liver, pyloric stomach, and hematopoietic system.

8 their HSPCs displayed attributes of an aged hematopoietic system.

9 at miR-142 is broadly expressed in the adult hematopoietic system.

10 re repopulate large parts of the recipient's hematopoietic system.

11 generate the lineal precursors of the adult hematopoietic system.

12 erful oncogene in the mammary epithelium and hematopoietic system.

13 acts independently from menin (Men1) in the hematopoietic system.

14 bryo is crucial for development of the adult hematopoietic system.

15 HSCs may underlie many features of the aged hematopoietic system.

16 with support of myeloid lineage cells in the hematopoietic system.

17 ograms and direct cell fate decisions in the hematopoietic system.

18 interactions between mammary cancers and the hematopoietic system.

19 e datasets in high-resolution mapping of the hematopoietic system.

20 inel of cellular stress in the liver and the hematopoietic system.

21 hemogenic endothelium to establish the adult hematopoietic system.

22 we generated mice lacking caspase-9 in their hematopoietic system.

23 e-has been previously developed to study the hematopoietic system.

24 mi1(-/-) mice reconstituted with a wild-type hematopoietic system.

25 odel that acutely deletes Grp78 in the adult hematopoietic system.

26 model with conditional TRF1 deletion in the hematopoietic system.

27 f controls the homeostasis of the Drosophila hematopoietic system.

28 nockout mouse model of GRP78 and PTEN in the hematopoietic system.

29 cellular depletion can reverse aging in the hematopoietic system.

30 esis and a primary target of miR-125b in the hematopoietic system.

31 g developmental defects and breakdown of the hematopoietic system.

32 the mouse and affects the composition of the hematopoietic system.

33 ent that is extensively expressed within the hematopoietic system.

34 escence and expansion/differentiation of the hematopoietic system.

35 significantly to p53-mediated effects on the hematopoietic system.

36 ing the essential autophagy gene Atg7 in the hematopoietic system.

37 an adaptor protein expressed in cells of the hematopoietic system.

38 (HSCs) with functional consequences for the hematopoietic system.

39 l of HSCs to sustain the highly regenerative hematopoietic system.

40 t of phagocytes are central functions of the hematopoietic system.

41 rotein selective functions that modulate the hematopoietic system.

42 d carcinogen, especially in reference to the hematopoietic system.

43 unctional defects of individual cells of the hematopoietic system.

44 led the activation of all 3 integrins in the hematopoietic system.

45 deleted FoxO1, FoxO3, and FoxO4 in the adult hematopoietic system.

46 l role for the development of the definitive hematopoietic system.

47 er as well as genetic diseases affecting the hematopoietic system.

48 antigen and other receptors in cells of the hematopoietic system.

49 natally and show profound alterations in the hematopoietic system.

50 aining multiple organ systems, including the hematopoietic system.

51 is and after perturbations of the endogenous hematopoietic system.

52 lly significant consequences of aging of the hematopoietic system.

53 nta in establishing the mammalian definitive hematopoietic system.

54 ells generally requires ablation of the host hematopoietic system.

55 h most cytokines acting in the immune and/or hematopoietic system.

56 of cell differentiation and apoptosis in the hematopoietic system.

57 gene expression to modulate cell fate in the hematopoietic system.

58 nt HSCs were also unable to reconstitute the hematopoietic system.

59 rstanding of the evolution of the vertebrate hematopoietic system.

60 rsed in Kras(G12D) mice lacking NLRP3 in the hematopoietic system.

61 ult THS exposure had profound effects on the hematopoietic system.

62 d challenges for genetic manipulation of the hematopoietic system.

63 e but experienced equivalent collapse of the hematopoietic system.

64 phoid-specific expression pattern within the hematopoietic system.

65 lular ubH2A level and gene expression in the hematopoietic system.

66 porting myeloid amplification to rebuild the hematopoietic system.

67 the development of several cell types in the hematopoietic system.

68 nesis specifically in the context of an aged hematopoietic system.

69 ariety of phenotypes within the skeletal and hematopoietic systems.

70 d the clonal collapse of both young and aged hematopoietic systems.

71 lar disease include the immune, nervous, and hematopoietic systems.

72 ns caused hyperproliferation in lymphoid and hematopoietic systems.

73 When this process happens in the hematopoietic system, a substantial proportion of circul

74 ettings, such as stimulating recovery of the hematopoietic system after bone marrow transplantation.

75 healthy donor HSPC not only reconstitute the hematopoietic system after transplantation, but also sup

76 stem cells (HSCs) generate all cells of the hematopoietic system, age-associated changes in HSCs may

77 In the human hematopoietic system, aging is associated with decreased

78 As with most tissues, the aged hematopoietic system also exhibits a reduced capacity to

79 uction contributes to homeostasis within the hematopoietic system and appropriate responsiveness to i

80 eloid malignancies often arise from an aging hematopoietic system and are currently incurable due to

81 s (HSCs) are the most primitive cells in the hematopoietic system and are under tight regulation for

82 ling of cancer cells both by stimulating the hematopoietic system and by enhancing CD8(+)-dependent t

83 er, PHD2-deficient HSCs replenish the entire hematopoietic system and display an enhanced self-renewa

84 ates Hox gene expression in the adult murine hematopoietic system and dysregulates Hox genes that are

85 sent study, specific deletion of PIT1 in the hematopoietic system and fetal liver transplantation exp

86 we specifically deleted the PDK1 gene in the hematopoietic system and found that PDK1-deficient HSCs

87 scription factor Myb plays a key role in the hematopoietic system and has been implicated in the deve

88 ce of Fbw7-dependent cyclin E control to the hematopoietic system and highlight CIN as a characterist

89 over 1,500 single cells throughout the mouse hematopoietic system and illustrate its utility for reve

90 acceleration of tumor formation both in the hematopoietic system and in sarcomas.

91 ts into the cell-cell cross talk between the hematopoietic system and its microenvironment in the bon

92 erized by the accumulation of B cells in the hematopoietic system and lymphoid tissues.

93 en limited to only a few tissues, mainly the hematopoietic system and mammary gland.

94 lly ablated geminin in the developing murine hematopoietic system and observed profound defects in th

95 ulation of HSCs maintains homeostasis of the hematopoietic system and participates in innate immune r

96 ls (HSCs) lie at the foundation of the adult hematopoietic system and provide an organism throughout

97 ch Scl functions in the establishment of the hematopoietic system and provide evidence that its prima

98 mitigated TBI-induced premature aging of the hematopoietic system and rejuvenated the aged HSCs and M

99 generated a mouse model lacking Hmgb1 in the hematopoietic system and studied the response to acute s

100 ssential for the functional integrity of the hematopoietic system and that its mutations likely contr

101 he complexity of the embryonic origin of the hematopoietic system and the developmental migration of

102 evere side effects that primarily affect the hematopoietic system and the epithelium of the gastroint

103 y described functional interplay between the hematopoietic system and the SNS extends to the earliest

104 s a disease of the vascular endothelium; the hematopoietic system and the vascular endothelium share

105 applied the technology to dissect the human hematopoietic system and to characterize heterogeneous r

106 genes uniquely expressed in HSCs within the hematopoietic system and to develop a reporter strain th

107 , in which Meg3 was deleted in the embryonic hematopoietic system and unexpectedly this did neither g

108 transcriptional control of Elf-4 within the hematopoietic system and, thus, integrate Elf-4 into the

109 udy identifies a link between the neural and hematopoietic systems and opens up the possibility of ma

110 lungs or a prenatally stress-exposed immune (hematopoietic) system and induced allergic asthma via ov

111 it in the maternal brain, rather than in the hematopoietic system, and during gestation was responsib

112 TEL2 is expressed in the hematopoietic system, and its expression is up-regulated

113 phasis on GATA-1 and GATA-2 functions in the hematopoietic system, and new links between GATA-2 dysre

114 cytes, representing the highly proliferative hematopoietic system, and skeletal muscle, a minimally p

115 n revealed fog1 expression in the heart, the hematopoietic system, and the brain, while fog2a and fog

116 sues, such as the intestinal epithelium, the hematopoietic system, and the male germline.

117 Chronic viral infections of the hematopoietic system are associated with bone marrow dys

118 ts treated for proliferative diseases of the hematopoietic system are characterised by a severe, prog

119 of Nf1 (Nf1(+/-)) and c-kit signaling in the hematopoietic system as required and sufficient for tumo

120 roles in the development and biology of the hematopoietic system, as evidenced by mouse and human ge

121 ong stem cells from different regions of the hematopoietic system at the same time during development

122 mited to the differentiated monocytes in the hematopoietic system both in human and mouse, the identi

123 patients with malignancies of the kidney or hematopoietic system but are often accompanied by severe

124 lycans (HSPGs), is expressed by cells of the hematopoietic system but its role in leukocyte biology i

125 s selectively rescued in the endothelial and hematopoietic systems but not in the skeleton.

126 cacious for multiple genetic diseases of the hematopoietic system, but roughly half of clinical gene

127 facilitates postinjury recovery of the mouse hematopoietic system by promoting proliferation and faci

128 nockdown of all A1 isoforms expressed in the hematopoietic system by RNA interference.

129 titutive or reversible ablation of A1 in the hematopoietic system by RNA interference.

130 Continuous challenge of the hematopoietic system by serial transplantation provoked

131 em cell fate decisions in the blood-forming (hematopoietic) system by providing a simple and broadly

132 ed both in the (micro)environment and in the hematopoietic system can accelerate thymic involution; h

133 adult angiogenic responses suggest that the hematopoietic system can be a source of endothelial cell

134 hat various tissues, especially parts of the hematopoietic system, can be rejuvenated.

135 aster regulatory transcription factor in the hematopoietic system, can result in a differentiation bl

136 induced by CpG in mice with a Stat3-ablated hematopoietic system cause potent antitumor effects, lea

137 RHAU deletion in hematopoietic system caused hemolytic anemia and differe

138 ere, we show that a deficiency of A20 in the hematopoietic system causes anemia, lymphopenia, and pos

139 Within the hematopoietic system, CD85j is expressed with cell-speci

140 ct its genomic and functional integrity, the hematopoietic system critically depends on the combined

141 The hematopoietic system declines with age, resulting in dec

142 The hematopoietic system declines with age.

143 IN can function as a tumor suppressor in the hematopoietic system: deletion of Atmin under the contro

144 Lineage specification in the hematopoietic system depends on the expression of lineag

145 Mice expressing active Kras(G12D) in the hematopoietic system developed myeloproliferation and cy

146 nges and downregulation of genes involved in hematopoietic system development and function.

147 The hematopoietic system develops during embryogenesis at te

148 Inactivation of Lrp5 and -6 in a hematopoietic system diminished the pool of HSCs, but th

149 Correspondingly, mice lacking Sphk2 in the hematopoietic system display thrombocytopenia.

150 ) mouse model, BMT mice with a reconstituted hematopoietic system displayed increased susceptibility

151 imeric wild-type mice with a CG/NE-deficient hematopoietic system displayed significantly increased l

152 arction (MI), myeloid cells derived from the hematopoietic system drive a sharp increase in systemic

153 ic mice expressing the mutated enzyme in the hematopoietic system driven by a vav gene promoter.

154 icated in the establishment of the primitive hematopoietic system during mouse embryonic development.

155 In mice, specific knockdown of SHIP1 in the hematopoietic system following retroviral delivery of a

156 Prdm16 deletion in the hematopoietic system following transplantation produced

157 LTR HSC can reconstitute the hematopoietic system for life, whereas STR HSC can susta

158 he ability of stem cells to reconstitute the hematopoietic system for many decades after the administ

159 athway represents a leading model within the hematopoietic system for the analysis of genetic network

160 ing sufficient H3K9me3 to protect the entire hematopoietic system from changes associated with premat

161 critical factors that govern recovery of the hematopoietic system from stress, such as during antican

162 Within the hematopoietic system, Ghr is expressed in a highly HSC-s

163 show that Prdm16 deletion in the adult mouse hematopoietic system has a less severe effect on HSCs, c

164 Together, our results indicate that the hematopoietic system has a remarkable tolerance for majo

165 ectively in the development of the mammalian hematopoietic system has been difficult to ascertain bec

166 In contrast, after the hematopoietic system has been perturbed by irradiation o

167 me time during development suggests that the hematopoietic system has evolved mechanisms to prevent t

168 a general role for the lipocalin 24p3 in the hematopoietic system has not been tested in vivo.

169 Therefore, strategies to rejuvenate the hematopoietic system have important clinical implication

170 ces in the understanding of the cells of the hematopoietic system have provided a rich basis for impr

171 velopment as well as normal functions of the hematopoietic system, heart, and kidney in adults.

172 In the adult hematopoietic system, HH signaling regulates intrathymic

173 such as the skin, gastrointestinal tract and hematopoietic system, homeostasis is dependent on the co

174 We further characterized the hematopoietic system in individuals with CH as follows:

175 marrow cells prior to reconstitution of the hematopoietic system in lethally irradiated mice.

176 by E2F transcription factors in a BM-derived hematopoietic system in mice, we uncovered a functional

177 econstitution of this genetically engineered hematopoietic system in mice.

178 re, we review recent studies implicating the hematopoietic system in plexiform neurofibroma genesis,

179 s a juxtacrine homeostatic adaptation of the hematopoietic system in stress myelopoiesis.

180 e Vav promoter to express MYC throughout the hematopoietic system in transgenic mice.

181 as warranted a therapeutic potential for the hematopoietic system in treating diseases of the CNS.

182 6 is expressed during the development of the hematopoietic system in vivo and in vitro and that its e

183 and to repopulate a functional multilineage hematopoietic system in vivo.

184 The hematopoietic systems in the irradiated recipients were

185 Many age-related changes in the hematopoietic system, in particular the clonal myeloid b

186 Human CMV (HCMV) uses members of the hematopoietic system including neutrophils for dissemina

187 ssing IL1RAP, with no apparent effect on the hematopoietic system, including CD34(+) stem cells.

188 s associated with significant changes in the hematopoietic system, including increased inflammation,

189 S exposure induces persistent changes in the hematopoietic system independent of age at exposure.

190 e that P2Y14 on stem/progenitor cells of the hematopoietic system inhibits cell senescence by monitor

191 NSG mice with human hematopoietic system injected with the HMGB1 antagonist

192 In the hematopoietic system, instead of causing the predicted B

193 of multiple tissues, including those of the hematopoietic system, intestine, muscle, brain, skin and

194 The development of the hematopoietic system is a dynamic process that is contro

195 Communication with the hematopoietic system is a vital component of regulating

196 Aging of the hematopoietic system is associated with an increased inc

197 Aging of the hematopoietic system is associated with myeloid malignan

198 However, the role of Dmtf1 in the hematopoietic system is entirely unknown.

199 The Drosophila larval hematopoietic system is founded by differentiated hemocy

200 the shared phenotype of self-renewal in the hematopoietic system is linked at the molecular level.

201 on and physiological relevance in the murine hematopoietic system is nevertheless elusive.

202 Although the kinetics of recovery of the hematopoietic system is normal, HSCs in a SPARC-deficien

203 s, but the regulation of this process in the hematopoietic system is poorly understood.

204 the vascular endothelium, in addition to the hematopoietic system, is a major contributor of plasma S

205 cell fraction at the foundation of the adult hematopoietic system, is currently of great interest and

206 lays an important role in the development of hematopoietic system, it is less well understood whether

207 and p21 and to induce MDM2 expression in the hematopoietic system, its downstream targets in TNBC are

208 tion of Lis1 (also known as Pafah1b1) in the hematopoietic system led to a severe bloodless phenotype

209 turation of the various cell lineages of the hematopoietic system, less is known about factors that g

210 h beta-arrestin1 and -2 are expressed in the hematopoietic system, loss of beta-arrestin2 preferentia

211 Aging leads to functional decline of the hematopoietic system, manifested by an increased inciden

212 The hematopoietic system matures from the fetal state, chara

213 that age-related changes in HSCs and in the hematopoietic system may not entirely be due to a degene

214 lopment of the cardiovascular, excretory and hematopoietic systems may be more closely related than p

215 Within the hematopoietic system, members of the Kruppel-like family

216 Overexpressing Lin28A in the mouse hematopoietic system mimicked the phenotype observed on

217 The fetal/neonatal hematopoietic system must generate enough blood cells to

218 In the hematopoietic system, mutations in IDH1 at arginine (R)

219 aracterized by the presence in the patient's hematopoietic system of a large cell population with a m

220 is their ability to reconstitute the entire hematopoietic system of hemoablated recipients.

221 riments showing that genetic deletion in the hematopoietic system of Janus kinase 2 (JAK2) abrogates

222 ficient LSK cells failed to reconstitute the hematopoietic system of lethally irradiated mice.

223 s were unable to adequately reconstitute the hematopoietic system of lethally irradiated recipients.

224 dressed these questions by investigating the hematopoietic system of mice deficient for Rev1, a core

225 The hematopoietic system of mice is established during the e

226 Analysis of the hematopoietic system of mice with the Apc(min) allele th

227 ifferentiated progeny, which can sustain the hematopoietic system of multiple hosts for a long time.

228 has enabled HSCs to be used to replenish the hematopoietic system of patients after chemotherapy or r

229 the leukemogenic potential of SET-CAN in the hematopoietic system of transgenic mice.

230 NF can be effectively supplied by either the hematopoietic system or the CNS, but the essential TNFR1

231 D88 deletion, predominantly in the liver and hematopoietic system, or were crossed with Akr1b7 Cre tr

232 idence indicates that cells derived from the hematopoietic system participate in angiogenesis.

233 egulate cell fate decisions in the mammalian hematopoietic system, playing crucial roles in stem cell

234 The hematopoietic system plays a major role in human health.

235 We show here that, within the hematopoietic system, Prdm16 is expressed very selective

236 The hematopoietic system produces new blood cells throughout

237 nown role in defense and debris removal, the hematopoietic system provides critical regenerative driv

238 The hematopoietic system provides numerous examples attestin

239 In the human hematopoietic system, rare self-renewing multipotent lon

240 e find that inhibition of let-7 in the adult hematopoietic system recapitulates fetal erythroid-domin

241 by donor HSC transplantation enabled stable hematopoietic system reconstitution in recipients with m

242 We find that deletion of SPPL3 in the hematopoietic system reduces numbers of peripheral NK ce

243 angiopoietin-like proteins (Angptls) in the hematopoietic system remain unknown.

244 the mechanistic basis for its impact on the hematopoietic system remains largely unresolved.

245 Widespread inactivation of RB in the murine hematopoietic system resulted in profound myeloprolifera

246 Dpy30 loss in the adult hematopoietic system results in severe pancytopenia but

247 gp96/grp94 deletion in the murine hematopoietic system results in thrombocytopenia, prolon

248 The hematopoietic system's myeloid bias was reflected by inc

249 n highly proliferative organs, including the hematopoietic system, small intestine, and testes.

250 nt a small and heterogeneous fraction of the hematopoietic system, specialized in antigen capture, pr

251 gp96 is also essential for expression of 14 hematopoietic system-specific integrins.

252 l vector HSPC gene therapy generates a human hematopoietic system stably marked at the clonal level b

253 In the hematopoietic system, stem cells are characterized by us

254 2b deletion in CD11c-expressing cells of the hematopoietic system survive to adulthood.

255 The hematopoietic system sustains regeneration throughout li

256 In the hematopoietic system, TGF-beta signaling controls a wide

257 nvolves a tumor/stromal interaction with the hematopoietic system that depends, at the molecular leve

258 Macrophages are versatile cells of the hematopoietic system that display remarkable functional

259 ata annotate developmental mechanisms in the hematopoietic system that enable a decision to be made e

260 n stem cells for tissue homeostasis like the hematopoietic system that forms immune cells, it is beli

261 CSF) is an endogenous peptide hormone of the hematopoietic system that has been shown to be neuroprot

262 CSF) is an endogenous peptide hormone of the hematopoietic system that has entered Phase I/II clinica

263 n powerful new methods for investigating the hematopoietic system that have provided transformative i

264 ically significant conditions arising in the hematopoietic system that include: diminution and decrea

265 ochromic, microcytic anemia intrinsic to the hematopoietic system that is associated with a decreased

266 AML) is an autosomal dominant disease of the hematopoietic system that is caused by heterozygous muta

267 To elucidate the properties of an aged human hematopoietic system that may predispose to age-associat

268 The only cells of the hematopoietic system that undergo self-renewal for the l

269 In the hematopoietic system, the ANS regulates stem cell niche

270 In the hematopoietic system, the function of the pathway has be

271 n, differentiation, and proliferation in the hematopoietic system, the intestine, the pancreas, and t

272 nd because they are broadly expressed in the hematopoietic system, their targeting may have unwanted

273 nerating immunocompromised mice with a human hematopoietic system, there are still several shortcomin

274 patterns of stem cell divisions in the human hematopoietic system throughout life.

275 s to assess activity and distribution of the hematopoietic system throughout the whole skeleton of re

276 receptor nuclear translocator (ARNT) in the hematopoietic system to ablate activity of both HIF-1alp

277 nt approach is to engineer the patient's own hematopoietic system to express high levels of the defic

278 homeostasis and highlight the ability of the hematopoietic system to respond to stress without signif

279 ve approach is to engineer the patient's own hematopoietic system to restore glucocerebrosidase expre

280 d with deficits in neurodevelopment and with hematopoietic system toxicity.

281 ding of the accumulation of mutations in the hematopoietic system upon aging.

282 determined that CFU-ECs are derived from the hematopoietic system using progenitor assays, and analys

283 ouse model and deleted Prdm16 in adult mouse hematopoietic system using the IFN-inducible Mx1-Cre Our

284 rs (CMPs) by deletion of Atmin in the entire hematopoietic system using Vav-Cre.

285 Beyond the hematopoietic system, Usp3Delta/Delta animals spontaneou

286 As expected, the hematopoietic system was most affected, with all subject

287 xposure and bone marrow transplantation, the hematopoietic system was successfully reconstituted over

288 nd exhibited GFP expression that, within the hematopoietic system, was restricted predominantly to ly

289 Using the hematopoietic system, we analyzed the relative importanc

290 In the hematopoietic system, we defined critical decision point

291 further explore its physiologic functions in hematopoietic system, we generated a mouse model with he

292 manull (NSG) mice reconstituted with a human hematopoietic system, we were able to discriminate the r

293 d that the effects of TCDD on the developing hematopoietic system were mediated by direct AHR activat

294 This is particularly true of the hematopoietic system, where demands on host defenses can

295 TL represents TL in the highly proliferative hematopoietic system, whereas TL in skeletal muscle repr

296 erated telomere shortening restricted to the hematopoietic system, which affects the baseline TL of a

297 defects in the development of the zebrafish hematopoietic system, which could be partially rescued b

298 Thus, Mi-2beta provides the hematopoietic system with immune cell capabilities as we

299 ntly requires depleting a patient's existing hematopoietic system with toxic and non-specific chemoth

300 R/R) mice display altered development of the hematopoietic system without enhanced tumor susceptibili