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1 iverdin requires oxygen for its synthesis by heme oxygenase.
2 analysis shows upregulation of ferritin and heme oxygenase.
3 m-positive bacteria that possess IsdG-family heme oxygenases.
4 al cytochrome P450 (P450) monooxygenases and heme oxygenases.
5 ikely common intermediate with the canonical heme oxygenases.
6 cts differ from those generated by canonical heme oxygenases.
7 talase, glutathione peroxidase 1 (GPX1), and heme oxygenase 1 (Hmox1) and transcription factor nuclea
9 We showed that variation in basal levels of heme oxygenase 1 (HMOX1) contribute to the response to O
10 ed reduced progesterone levels and placental heme oxygenase 1 (Hmox1) expression and increased methyl
11 h regulates the expression of genes encoding heme oxygenase 1 (Hmox1), glutamate-cysteine ligase cata
14 ession of heat-shock protein 70 (HSP-70) and heme oxygenase 1 (HO-1) and promoted cell survival after
18 ctor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) gene proteins in retinal tissues
19 investigated whether up-regulation of DAF by heme oxygenase 1 (HO-1) is an underlying mechanism by us
21 e 2 signaling response, downstream of which, heme oxygenase 1 (HO-1) was also found to be time-depend
23 (hIL-10R) by cmvIL-10 led to upregulation of heme oxygenase 1 (HO-1), an enzyme linked with suppressi
24 overexpression of the heme-degrading enzyme, heme oxygenase 1 (HO-1), has been shown to protect mice
25 NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase 1 (HO-1), typical chemoprotective gene pr
27 on a key enzyme involved in heme catabolism, heme oxygenase 1 (HO-1), which, ironically, has been poo
34 kers (matrix metalloproteinase 1 [MMP-1] and heme oxygenase 1 [HO-1]), and proinflammatory cytokines
35 The carboxyhemoglobin level (a measure of heme oxygenase 1 activity) has not been assessed in adul
37 orresponded with increases in cytoprotective heme oxygenase 1 and IL-10 mRNAs, selective reductions i
38 ential for linked antioxidant protection via heme oxygenase 1 and reduced foam cell formation via liv
40 ion, hypoxia-inducible factor 1alpha-induced heme oxygenase 1 expression resulting in improved surviv
42 med a systematic review and meta-analysis of heme oxygenase 1 gene (HO-1) promoter polymorphisms and
43 ), intercellular adhesion molecule 1, IL-10, heme oxygenase 1 hypoxia-inducible factor 1 (HIF-1), mon
44 ssion of hypoxia-inducible factor 1alpha and heme oxygenase 1 in the hippocampus was increased in the
45 Cobalt protoporphyrin (CoPP), a well known heme oxygenase 1 inducer, has been used to promote endog
47 t upregulation of superoxide dismutase 2 and heme oxygenase 1 protein following hypoxia-reoxygenation
49 ples for hypoxia-inducible factor 1alpha and heme oxygenase 1, and 4) immunohistochemistry of hippoca
50 H(2)O(2), concomitant with up-regulation of heme oxygenase 1, COX-2, and anti-apoptotic proteins (BC
53 on of antioxidant genes, including those for heme oxygenase 1, NAD(P)H quinone oxidoreductase 1, and
54 most robustly increased genes and proteins, heme oxygenase 1, NADPH-quinone oxidoreductase 1, and gr
55 ulation of H2A histone family, member X, and heme oxygenase 1, which were experimentally validated as
57 ncreased inducible nitric oxide synthase and heme-oxygenase 1 expression, and increased MDA and plasm
58 ncreased inducible nitric oxide synthase and heme-oxygenase 1 expression, and increased plasma creati
59 f Bcl-2 (5.5-folds), Bcl-xl (5.5-folds), and heme oxygenase-1 (4.4-folds); decreased expression of IC
61 adenoassociated virus (rAAV)-encoding human heme oxygenase-1 (hHO-1) in attenuating post-ischemic in
62 n (HP), cluster of differentiation (CD) 163, heme oxygenase-1 (HMOX1), and biliverdin reductase A (BL
64 otective response relies on the induction of heme oxygenase-1 (HMOX1; HO-1) and ferritin H chain (FTH
67 f2, NAD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1) and a high ratio of Bcl-2/Bax.
68 production of antioxidant enzymes, including heme oxygenase-1 (HO-1) and glutathione peroxidase 1 (Gp
69 of the antioxidant/anti-inflammatory enzyme heme oxygenase-1 (HO-1) and increased neuroinflammation
73 d CXCL8 secretion and required activation of heme oxygenase-1 (HO-1) and phosphorylated adenosine mon
74 cells by the regulations of novel molecules heme oxygenase-1 (HO-1) and programmed death-1 ligand 1
76 a hypoxia-inducible plasmid expressing both heme oxygenase-1 (HO-1) and the Src homology domain-2 co
78 AC and selected reaction monitoring revealed heme oxygenase-1 (HO-1) as the most significantly up-reg
79 he cytoprotective and antiapoptotic molecule heme oxygenase-1 (HO-1) at the transcriptional level.
85 a, urine, and tissues, which in turn induces heme oxygenase-1 (HO-1) expression in the colonic epithe
87 vitro study showed that adiponectin induced heme oxygenase-1 (HO-1) expression through the peroxisom
89 ase expression, nitric oxide production, and heme oxygenase-1 (HO-1) expression, which was associated
91 al injury, and inhibited RPTC Nrf2, Agt, and heme oxygenase-1 (HO-1) gene expression in Akita Cat tra
93 lective overexpression of the stress protein heme oxygenase-1 (HO-1) in astrocytes of novel GFAP.HMOX
94 the products of the cytoprotective molecule heme oxygenase-1 (HO-1) in cancer cells, has been implic
95 of NO induce the anti-inflammatory effector heme oxygenase-1 (HO-1) in gastric epithelial cells thro
96 of the cytoprotective, heme-degrading enzyme heme oxygenase-1 (HO-1) in neutrophil progenitors in bon
97 e antioxidative and anti-inflammatory enzyme heme oxygenase-1 (HO-1) in the brains of individuals wit
98 ed a hypothesized anti-inflammatory role for heme oxygenase-1 (HO-1) in the development of metabolic
115 The stress-inducible cytoprotective enzyme heme oxygenase-1 (HO-1) may play a critical role in the
117 ukin-8 (IL-8), cyclooxygenase-2 (COX-2), and heme oxygenase-1 (HO-1) mRNA was measured in BEAS-2B cel
118 of inducing the activity of the host enzyme heme oxygenase-1 (HO-1) on hRSV replication and pathogen
120 overexpression of the cytoprotective enzyme heme oxygenase-1 (HO-1) play a critical role in the grow
123 Only overexpression of the gene encoding heme oxygenase-1 (HO-1) significantly correlated with in
125 y amplified in human breast cancers, induced heme oxygenase-1 (HO-1) through Nrf2 transactivation in
127 erythroid 2p45-related factor-2 (Nrf2), and heme oxygenase-1 (HO-1) was tested in both in vitro and
128 up-regulation of the cytoprotective protein heme oxygenase-1 (HO-1) which is capable of mitigating a
129 amplification with pNaKtide and induction of heme oxygenase-1 (HO-1) with cobalt protoporphyrin (CoPP
130 d that PRRSV downregulates the expression of heme oxygenase-1 (HO-1), a pivotal cytoprotective enzyme
133 ter antioxidant transcription factor, and of heme oxygenase-1 (HO-1), one of its main target genes, i
134 ome solid tumors and myeloid leukemia cells, heme oxygenase-1 (HO-1), the anti-oxidant, anti-inflamma
135 attention as a master protective sentinel is heme oxygenase-1 (HO-1), the rate-limiting step in the c
137 Many cancer cells constitutively express heme oxygenase-1 (HO-1), which catabolizes heme to gener
138 is the up-regulation of the inducible enzyme heme oxygenase-1 (HO-1), which catabolizes heme to gener
139 Intracellular heme levels are regulated by heme oxygenase-1 (HO-1), which catalyzes the degradation
141 ng expression of the stress response protein heme oxygenase-1 (HO-1), which interacts with and thereb
142 ory functions, preclinical studies encourage heme oxygenase-1 (HO-1)-inducing regimens in clinical or
150 is generated by the stress-responsive enzyme heme oxygenase-1 (HO-1, encoded by Hmox1), which is high
154 quality control is regulated in part by the heme oxygenase-1 (HO-1; Hmox1) system through the redox-
156 mL; CO-E-CPR, 89 +/- 26 pg/mL; p < 0.05) and heme oxygenase-1 (sham, 1 +/- 0.1; cardiopulmonary resus
158 ranofin displayed synergistic lethality with heme oxygenase-1 and glutamate-cysteine ligase inhibitor
160 e discuss here new insights into the role of heme oxygenase-1 and heme on cardiovascular health, and
161 ontractility rather than passive stretch via heme oxygenase-1 and histone deacetylase signalling.
162 d4 to Nrf2-binding sites on the promoters of heme oxygenase-1 and NADPH quinone oxidoreductase 1.
163 rf2 or DJ-1 attenuated Cu((II))ATSM-mediated heme oxygenase-1 and NADPH quinone oxidoreductase-1 indu
164 into the nucleus to induce transcription of heme oxygenase-1 and other cytoprotective enzymes throug
167 arkable cardioprotective effects ascribed to heme oxygenase-1 are best evidenced by its ability to re
169 nhancing expression of the IL-10 target gene heme oxygenase-1 by mechanisms dependent on p38 MAPK act
172 enhances its paracine effects on RIII via a heme oxygenase-1 dependent mechanism, which may help us
174 s, whereas treatment with carbon monoxide, a heme oxygenase-1 enzymatic product, abrogated this effec
175 als treated with tin protoporphyrin (SnPP, a heme oxygenase-1 enzyme inhibitor), even after Ad.Trx1 t
177 -induced oxidative stress by down-regulating heme oxygenase-1 expression via nuclear factor (erythroi
179 nosine thymidine dinucleotide repeats in the heme oxygenase-1 gene promoter in 386 patients with coro
180 nosine thymidine dinucleotide repeats in the heme oxygenase-1 gene promoter is associated with cardio
181 nosine thymidine dinucleotide repeats in the heme oxygenase-1 gene promoter is associated with higher
184 duced expression of the Nrf2 target protein, heme oxygenase-1 in the skin and protected against UVB-i
186 vivo and IRAK-M(-/-) AECs in vitro with the heme oxygenase-1 inhibitor, tin protoporphyrin, substant
187 a 7-day doxycycline treatment sustained high heme oxygenase-1 levels during the entire period of hypo
188 T6 recruits BAF170 to enhancer region of the Heme oxygenase-1 locus and promotes recruitment of RNA p
191 related with CO in the breath were levels of heme oxygenase-1 protein in serum and HMOX1 transcripts
192 ted bitransgenic mice that overexpress human heme oxygenase-1 under doxycycline control in an inducib
195 tide phosphate:quinone oxidoreductase 1, and heme oxygenase-1 were lower in group 2 than group 3.
197 based proteomics screen, we identified HO-1 (heme oxygenase-1), the rate-limiting enzyme in the degra
198 ) mice have increased expression/activity of heme oxygenase-1, a phase II antioxidant, and NF (erythr
199 aimed to investigate the mechanisms by which heme oxygenase-1, an anti-inflammatory enzyme, is protec
200 , despite significantly higher expression of heme oxygenase-1, an antioxidant and cytoprotective enzy
201 ntioxidant systems such as peroxiredoxins-1, heme oxygenase-1, and anti-apoptotic factors, including
202 ed anti-inflammatory factors interleukin-10, heme oxygenase-1, and Hsp70 in macrophages stimulated or
203 ing IL-1ra, IL-10, and PGE(2), but not IL-6, heme oxygenase-1, and NO, attenuated 5-FU-MSC-induced im
205 lation of the oxidative stress response gene heme oxygenase-1, and we demonstrated that NF-kappaB inh
207 lial NOS (eNOS), Nrf2, and Phase II enzymes (heme oxygenase-1, catalase, superoxide dismutase-1) in a
208 ation of the CBS inhibitor, CO, a product of heme oxygenase-1, flip the operating preference of CSE f
209 expression of Nrf2-dependent genes, such as heme oxygenase-1, glutamate-cysteine ligase catalytic su
210 tor-kappaB, hypoxia-inducible factor-1alpha, heme oxygenase-1, inducible nitric oxide synthase, B-cel
211 itochondrial superoxide dismutase (SOD), and heme oxygenase-1, mucosal receptors such as the Toll-lik
212 e regulation of key Nrf2 target genes (i.e., heme oxygenase-1, NAD(P)H dehydrogenase, quinone 1, glut
213 ificantly upregulates Nrf2-responsive genes, heme oxygenase-1, NAD(P)H quinone oxidoreductase 1, and
214 n and expression of the antioxidant proteins heme oxygenase-1, NADPH quinone oxidoreductase 1, and gl
215 such as superoxide dismutase, nitric oxide, heme oxygenase-1, neutrophil infiltration, cysteamine, m
216 es that impair liver regeneration, including heme oxygenase-1, programmed cell death 4, and the cycli
217 pression levels of survival genes, Bcl-2 and heme oxygenase-1, were analyzed by gene array analysis a
225 em macrophages through coregulation of HO-1 (heme oxygenase-1; HMOX1) and lipid homeostasis genes.
226 the CX3CR1 receptor induced upregulation of heme-oxygenase-1 (HMOX-1), an antioxidant and anti-infla
227 Q61L) mutant induced the anti-oxidant enzyme heme-oxygenase-1 (HO-1) through activation of NRF2.
230 reverses vitamin C-induced up-regulation of heme-oxygenase-1 and ferritin in KRAS-mutant cancer cell
231 ntrol animals, and inhibiting the HIF target heme-oxygenase-1 before IR reduced GFR in STN animals.
233 with higher substrate affinity of the enzyme heme oxygenase 2, whereas SH rats present lower substrat
237 ate binding site within the cellular protein heme oxygenase-2 that acts as a trap to inhibit N-myrist
239 vel cytotoxic isoflavone is shown to inhibit heme oxygenase, a desirable yet elusive target that disr
241 s sp. strain PCC 7002 comprises two enzymes: heme oxygenase and phycocyanobilin synthase (PcyA).
242 Tetrapyrrole substrates and products of heme oxygenase are potent inhibitors of hepatitis C viru
243 xide synthase, type 1 heme oxygenase, type 2 heme oxygenase, Bax, and Bcl-2 protein and mRNA expressi
244 on of genes encoding bacteriophytochromes or heme oxygenase clearly show that both bacteriophytochrom
245 metabolic shift to the PPP is controlled by heme oxygenase-dependent generation of carbon monoxide (
246 , homologs of which have been proposed to be heme oxygenases, did not eliminate (13)C-BV IXdelta and
249 antibacterial effects while CO, generated by heme oxygenases, enhances phagocytosis of macrophages.
250 acquires the following characteristics of a heme oxygenase enzyme: (a) donation by His429 of an addi
253 her outbreak isolates were found to harbor a heme oxygenase gene (hemO)-containing gene cluster.
254 ve previously shown the catalytic actions of heme oxygenase (HemO) along with the cytoplasmic heme tr
255 stant infections, such as the iron-regulated heme oxygenase (HemO) of Pseudomonas aeruginosa, due to
259 final round, we discovered that deletion of heme oxygenase (HMX1) increases total heme concentration
260 ies production and upregulated expression of heme oxygenase HO-1 (HMOX1), an indicator of oxidative s
261 We hypothesize that in beta-thalassemia heme oxygenase (HO) 1 could play a pathogenic role in th
262 ibited activity of the renoprotective enzyme heme oxygenase (HO) and determined the effects on renal
269 n), astrocyte activation, IgG extravasation, heme oxygenase (HO), iron deposition, oxidative end prod
272 Carbon monoxide (CO), an end-product of heme oxygenase (HO)-1 activity, can confer anti-inflamma
273 At the molecular level, the expression of heme oxygenase (HO)-1 and the secretion of stromal cell-
275 the expression of antioxidant genes, such as heme oxygenase (HO)-1, that protect parasites from oxida
276 , IL-4, and IL-6 and oxidative stress marker heme oxygenase (HO)-1, were higher in WD+VDD versus WD a
280 embrane potential and increases in cytosolic heme oxygenase (HO-1) expression and mitochondrial coloc
282 s that interact with HIV-1 MA, we found that heme oxygenase (HO-2) specifically binds the myristate m
283 nduces expression of the CO-producing enzyme heme oxygenase (HO1) and that CO is sensed by M. tubercu
289 ray crystal structure showed that UndA has a heme-oxygenase-like fold, thus associating it with a str
290 used by the massive induction by arsenite of heme oxygenase mRNA (HMOX1; 68-fold increase), the rate-
291 mparable in both types of donors, the type 1 heme oxygenase mRNA expression and antioxidant enzyme ac
292 flux of extracellular heme through the HemO heme oxygenase, resulting in more-efficient heme utiliza
297 that B. abortus 2308 has at least one other heme oxygenase that works in concert with BhuQ to allow
299 ase, inducible nitric oxide synthase, type 1 heme oxygenase, type 2 heme oxygenase, Bax, and Bcl-2 pr
300 n the kidneys, whereas high levels of C3 and heme oxygenase were identified in pancreas biopsies.