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1 MS tetramer") or a product-substrate dimer ("hemiacetal").
2 lled installation of the labile transannular hemiacetal.
3 g Ser239 in beta(3) tubulin, presumably as a hemiacetal.
4 wo aldehyde groups, one of which exists as a hemiacetal.
5  is driven to completion by cyclization to a hemiacetal.
6 on of an intermediate flavin C4a-hydroperoxy hemiacetal.
7 y labile intermediates to racemic versiconal hemiacetal.
8 with phenolic acetate via the formation of a hemiacetal.
9  water followed by cleavage of the resulting hemiacetal.
10 yde, and subsequent proton migration gives a hemiacetal.
11 n to the carbonyl and by the C-O cleavage of hemiacetal.
12 em had a carbonyl group in a free form or as hemiacetal.
13 on of a bicyclic isoxazolidine-derived azido-hemiacetal.
14 stabilized phosphorus ylide bearing an omega-hemiacetal.
15 otolyzed without involvement of a long-lived hemiacetal.
16 st in equilibrium with stereoisomeric cyclic hemiacetals.
17                    The phosphorylated cyclic hemiacetals 1 and 2 were isolated as binary mixtures of
18 zation, rearrangement, and ring expansion of hemiacetal, 15, is proposed.
19 H followed by reduction with thiourea led to hemiacetal 22.
20   Hence, the sodium borohydride reduction of hemiacetals 2a,b can be controlled to give either a bicy
21               The addition of allylindium to hemiacetals 2a,b occurs both regio- and diastereoselecti
22 during the sulfoxide-catalyzed conversion of hemiacetal 3 to glycosyl sulfonate 10.
23 7 was introduced leading to a mixture of the hemiacetals 48 and the corresponding ketone 49.
24 ton of the hydroxyl residue of the substrate hemiacetal 6-OH group.
25 n stimulated with motilin, erythromycin, 6,9-hemiacetal 8,9-anhydro-4''-deoxy-3'-N-desmethyl-3'-N-eth
26                                              Hemiacetal 9 can be converted to an acetal, reduced to a
27 e conversion of averufin (AVF) to versiconal hemiacetal acetate (VHA), in Aspergillus parasiticus and
28 perturbations, provides strong evidence that hemiacetal activation proceeds through initial nucleophi
29           Mechanistic studies focused on the hemiacetal activation process show that this transformat
30           The X-ray crystal structure of the hemiacetal adduct between Ser 195 of chymotrypsin and N-
31 able product compared to Michael adducts and hemiacetal adducts and also indicating that water molecu
32 re also isolated, including Michael adducts, hemiacetal adducts, and pyridinium salt adducts, at the
33 se Bis-Acetal-Based Substrates (BABS) bear a hemiacetal aglycon leaving group that tethers fluorochro
34 xist as an equilibrating mixture of a cyclic hemiacetal and a ring-opened aldehyde.
35                The protonation states of the hemiacetal and His 57 are explained by the high basicity
36          During the ZA-assisted process, the hemiacetal and the BI act as hydrogen bond donors to sta
37 y 1H NMR indicates that isomerization of the hemiacetal and/or hemiketal is rapid.
38  the glycosylation between 2,6-dideoxy-sugar hemiacetals and glycosyl acceptors in good yield and hig
39 and aldehyde, and they show the formation of hemiacetals and hemiketals on binding small guests with
40 te donors are prepared in situ from glycosyl hemiacetals, and are coupled under mild, operationally s
41 bright-state ketones to dark-state hydrates, hemiacetals, and hemithioacetals is demonstrated for twi
42 nd interactions between the ZA and the BI or hemiacetal are analyzed.
43 vator and the reactivity of a glycosyl donor hemiacetal are matched.
44                   We found that formaldehyde hemiacetals are a considerable fraction of the total for
45                  The structures of the bound hemiacetals are determined by 1D and 2D NMR studies.
46           Although the health effects of the hemiacetals are not yet known, they warrant further inve
47                    The prochiral photoketene hemiacetals are procured from excited alpha,beta-unsatur
48 oacetate with a difluorinated aldehyde ethyl hemiacetal as a key step.
49  and reductive ring opening of the resulting hemiacetal as the key steps.
50 nstrates that use of promoters that activate hemiacetals as well-defined intermediates can be used to
51 th chymotrypsin is consistent with a neutral hemiacetal between pH 7 and 13.
52 teraction between the hydroxyl oxygen at the hemiacetal C1 of GAP and the nicotinamide ring.
53 dducts in the R- and S-configurations at the hemiacetal carbons.
54           At pH <7.0, His 57 in the AcLF-CHO-hemiacetal complex of chymotrypsin undergoes protonation
55                             The formaldehyde hemiacetals derived from these solvents were reported as
56  hemiacetals on the metal sites, followed by hemiacetal diffusion to a nearby Bronsted acid site to d
57                                 These cyclic hemiacetals effectively mask the reactive aldehydes nece
58     The reason for this is that formaldehyde hemiacetals follow other reaction pathways, such as the
59 converting the C-1 anomeric carbon into free hemiacetal followed by intramolecular reductive aminocyc
60 ially available trifluoroacetaldehyde methyl hemiacetal, followed by a classical chemical resolution,
61 conjugate addition, leading to chiral cyclic hemiacetals, followed by a multicomponent reaction with
62 (10%), monohydrated acyclic (5%), and cyclic hemiacetal form (85%) of orthophthalaldehyde (OPA).
63 ntrast, its reversible reaction product, the hemiacetal form (A'), is not affected by temperature.
64 nfiguration of the C1' hydroxyl group of the hemiacetal form on duplex structure and abasic site repa
65 s in a carbohydrate-like fashion in a cyclic hemiacetal form under aprotic conditions.
66 -modification produces 3-thiolated sugars in hemiacetal form, rather than typical glycosides.
67 ther the abasic site is in the alpha or beta hemiacetal form.
68 sing or decreasing the product pH, to induce hemiacetal formation and acetal stabilization or induce
69 significant role in oligomer formation, with hemiacetal formation less important, and aldol condensat
70 ation after changing CysI to serine suggests hemiacetal formation.
71 -hand with a stabilizing O-methylation and a hemiacetal formation.
72 mechanism in which the hydroxyl group of the hemiacetal formed upon addition of methanol to the aldeh
73 the aldehyde, the hydrated aldehyde, and the hemiacetal forms (dominant).
74 necarboxylic acid obtained from the gem-diol/hemiacetal forms and the polymerization products after t
75 trolled dehydrative coupling of various C(1)-hemiacetal glycosyl donors and nucleophilic acceptors pr
76 of the hydroxyl moiety of the intramolecular hemiacetal group and the phenolic hydrogen.
77 yclic carbohydrates, with and without a free hemiacetal group, is observed.
78 en established in the context of a versatile hemiacetal hydroxyl activation/substitution reaction for
79 through initial nucleophilic addition of the hemiacetal hydroxyl to the S(IV)-center of putative sulf
80 sual tetrahydrofuran ring with a concomitant hemiacetal in its structure.
81                 The presence of these cyclic hemiacetals in duplex DNA is significant as they mask th
82 nesulfonic anhydride activates 2-deoxy-sugar hemiacetals in situ as electrophilic species, which reac
83 abilize the transition state oxyanion of the hemiacetal intermediate in support of the flip-flop mode
84 resolved UV-vis measurements showed that the hemiacetal intermediate is formed by two competing pathw
85 d route, the proton migration leading to the hemiacetal intermediate is the rate-determining step (De
86          A superposition of NAD(+)-bound and hemiacetal intermediate structures reveals an interactio
87 , consistent with synthesis of a short-lived hemiacetal intermediate that breaks down spontaneously i
88 ciated H-bond, and the crucial ferric peroxo-hemiacetal intermediate that precedes carbon-carbon (C-C
89 ver, proton-assisted homolysis of the peroxo hemiacetal intermediate to produce P450 compound I and t
90  aliphatic alcohols showed that a long-lived hemiacetal intermediate was formed during the reaction.
91 matic states, NAD(+)-free, NAD(+)-bound, and hemiacetal intermediate.
92 h a dynamic kinetic resolution of the peroxy hemiacetal intermediate.
93 illman reaction involving the formation of a hemiacetal intermediate.
94 ly hydrosilylate esters to mixed silyl/alkyl hemiacetal intermediates but also catalyze the reduction
95                                              Hemiacetal intermediates for the rate-limiting proton tr
96 ydrolysis of benzaldehyde dialkyl acetals to hemiacetal intermediates that breakdown rapidly to benza
97 dehydes, and ketones through the collapse of hemiacetal intermediates.
98 es confirm that, under these conditions, the hemiacetal is quantitatively converted into an alpha-gly
99 classic acid-catalyzed hydrolysis, where the hemiacetal is the putative intermediate responsible for
100 BS) in which a racemic substrate, versiconal hemiacetal, is cyclized to an optically active product w
101 transient photoenol, in the form of a ketene hemiacetal, is enantioselectively protonated with a chir
102                                  We find the hemiacetal leaving group rapidly breaks down, enabling q
103 f CysI by alanine, which cannot form a (thio)hemiacetal, led to even higher activities, pointing to a
104 Surprisingly, the (R) stereochemistry at the hemiacetal linkage is opposite to that expected by compa
105                            Hydrolysis of the hemiacetal linkage of some of these modified carbohydrat
106                                          The hemiacetal linkages to the essential Ser146 are of a sin
107 addition of H* atoms to the carbonyl to form hemiacetals on the metal sites, followed by hemiacetal d
108 lier peroxide identifications may in fact be hemiacetals or ethers.
109           The bismuth-mediated two-component hemiacetal/oxa-conjugate addition of delta-trialkylsilyl
110 57 are explained by the high basicity of the hemiacetal oxygen (pK(a) > 13.5) relative to that of His
111 oton from solution, it is concluded that the hemiacetal oxygen of the chymotrypsin-AcLF-CHO complex i
112                                   In the (R)-hemiacetal, oxygen is hydrogen bonded to His 57, not the
113 erating in this multistep domino-aldol-aldol-hemiacetal protocol was used for probing the efficiency
114                       The domino-aldol-aldol-hemiacetal-reaction cascade of indium and other group 13
115 oxyl hydroperoxide intermediates followed by hemiacetal ring closure.
116 7,24-dien-3beta-ol, resulting in spontaneous hemiacetal ring formation and the production of the prot
117 as determined that these compounds contained hemiacetal ring structures and two double bonds, as woul
118 lesterol by nucleophilic addition, forming a hemiacetal salt.
119 eated with hydrochloric acid to liberate the hemiacetal shown.
120  site hole and assists in the opening of the hemiacetal, shows conformational exchange.
121 eavage of the glycosidic bond, the liberated hemiacetal spontaneously breaks down, leading to separat
122 formation of acetal to aldehyde occurs via a hemiacetal TFA ester intermediate, which differentiates
123 chlorophenoxyacetic acid (2,4-D) producing a hemiacetal that spontaneously decomposes to 2,4-dichloro
124 d less nucleophilic than that derived from a hemiacetal, the nondirected reaction is much slower for
125 rom the refined structures of the two cyclic hemiacetals, the conformations of the corresponding dias
126  two equilibrating enantiomers of versiconal hemiacetal to cyclize the appropriate antipode to optica
127 side chain cyclization of racemic versiconal hemiacetal to the bisfuran ring system of(-)-versicolori
128                                    The azido-hemiacetal was also converted into an aza-C-glycoside im
129 e 5'-direction, while the (6R,8S,11R) cyclic hemiacetal was oriented in the 3'-direction.
130                       The (6S,8R,11S) cyclic hemiacetal was oriented in the 5'-direction, while the (
131 ereomeric (6S,8R,11S) and (6R,8S,11R) cyclic hemiacetals were examined with respect to conformation w
132 the study described herein, the formaldehyde hemiacetals were found at higher levels than those of fr
133  Both the (6S,8R,11S) and (6R,8S,11R) cyclic hemiacetals were located within the minor groove of the
134 oth exist primarily as diastereomeric cyclic hemiacetals when placed into duplex DNA.
135 he abasic site in CD is predominantly a beta hemiacetal, whereas in AD the alpha and beta forms are e
136 hi cross-coupling affording an omega-hydroxy hemiacetal which was macrocyclized via a domino addition
137  the conversion of the ZA to a more reactive hemiacetal, which is further decomposed to the BI with t
138 hen rapidly adds to the enol ether to form a hemiacetal, which then undergoes elimination to cyclohex
139             We demonstrate that activating a hemiacetal with a sulfonyl chloride, followed by treatin
140 ormal 1,3-proton transfer in the photoketene hemiacetal with CPA as a proton shuttle delivers alpha-b
141 ive ("parasitic") intermediate, namely a N,O-hemiacetal with trifluoroacetophenones.
142 ation between 2-deoxy- and 2,6-dideoxy-sugar hemiacetals with various acceptors in good yields and hi
143 he respective orientations of the two cyclic hemiacetals within the minor groove were dependent upon

 
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