ライフサイエンスコーパス: hemidesmosome

1 180 into the cell surface at the site of the hemidesmosome.

2 is a type II transmembrane component of the hemidesmosome.

3 ane via a multimolecular junction called the hemidesmosome.

4 BTB dynamics directly and/or indirectly via hemidesmosome.

5 e beta4 cytoplasmic domain and disruption of hemidesmosomes.

6 hc and signaling to ERK but not formation of hemidesmosomes.

7 herin to adherens junctions and myotactin to hemidesmosomes.

8 els formed ample numbers of normal appearing hemidesmosomes.

9 beling, and there was variable hypoplasia of hemidesmosomes.

10 expressed in the lens, but in the absence of hemidesmosomes.

11 presence of junctional blisters and abnormal hemidesmosomes.

12 nced by less abundant and irregularly spaced hemidesmosomes.

13 ning the same peptide, they fail to assemble hemidesmosomes.

14 d muscle-induced tension transmitted through hemidesmosomes.

15 so becomes competent to nucleate assembly of hemidesmosomes.

16 ha6 beta4 integrin, an integral component of hemidesmosomes.

17 e epidermis to the basement membrane through hemidesmosomes.

18 s pathway, and with cytoskeletal elements of hemidesmosomes.

19 the failure to form anchoring filaments and hemidesmosomes.

20 e in adherence, even though they do not form hemidesmosomes.

21 ion components cause incomplete formation of hemidesmosomes.

22 e dorsal and ventral epidermis, there are no hemidesmosomes.

23 normal alpha6beta4 integrin clustering into hemidesmosomes.

24 ckout mice, leading to restored formation of hemidesmosomes.

25 ing that the defect was in reassembly of the hemidesmosomes.

26 1109) that is unable to assemble into mature hemidesmosomes.

27 s critical for the ability of EGF to disrupt hemidesmosomes.

28 ve mua-6 null allele localizes to hypodermal hemidesmosomes.

29 signaling, alpha6beta4 mediates assembly of hemidesmosomes.

30 alpha6beta4-mediated adhesion or assembly of hemidesmosomes.

31 scopy revealed rudimentary, poorly developed hemidesmosomes.

32 pha 6 beta 4 is involved in BM anchorage via hemidesmosomes.

33 phosphorylation of beta4 and disassembly of hemidesmosomes.

34 tained beta3 expression and the formation of hemidesmosomes.

35 m directly attaches to the tooth surface via hemidesmosomes, a soft diet requires minimal mastication

36 K14(+) cells were enriched for desmosome and hemidesmosome adhesion complex genes, and were depleted

37 in prevents reassembly of the BMZ and mature hemidesmosomes after keratectomy in beta6(-/-) mice.

38 and bullous pemphigoid antigen 2 within the hemidesmosomes along the basolateral surface of the epit

39 Within each hemidesmosome, alpha6beta4 integrin plays a crucial role

40 alpha6beta4 integrin, a component of hemidesmosomes, also plays a role in keratinocyte migrat

41 required for keratin filament linkage to the hemidesmosome, an adhesion complex in epithelial basal c

42 disorders resulting from defects in several hemidesmosome-anchoring filament components.

43 ha 6 beta 4 is an essential component of the hemidesmosome and a target of such regulation.

44 ly, basal cell markers, including integrins, hemidesmosome and extracellular matrix components, are s

45 dermal blister formation at the level of the hemidesmosome and is associated with a myopathy of unkno

46 rs gamma-tubulin and NOCA-1 are recruited to hemidesmosomes and adherens junctions early in elongatio

47 ermis of these mice contains well-structured hemidesmosomes and adheres stably to the basement membra

48 s of pp126 epithelial cells fail to assemble hemidesmosomes and are motile.

49 nd functional dynamics of the biology of the hemidesmosomes and basement membranes.

50 alpha6beta4 integrin, decreased formation of hemidesmosomes and decreased assembly of the actomyosin

51 ysis of superficial cells, but the number of hemidesmosomes and desmosomes are normal in basal and su

52 alpha 6 beta 4 in the formation of complete hemidesmosomes and in stable adhesion of basal keratinoc

53 ous cell carcinoma cells, which have reduced hemidesmosomes and increased beta4 phosphorylation, an i

54 e that this mobilization of alpha6beta4 from hemidesmosomes and its redistribution to cell protrusion

55 sing dominant negative Fyn display increased hemidesmosomes and migrate poorly in vitro in response t

56 at specialized adhesive structures known as hemidesmosomes and plays a critical role in diverse epit

57 in-a laminin-5 receptor-mediates assembly of hemidesmosomes and recruitment of Shc and phosphoinositi

58 n, bradykinin, or acetylcholine can increase hemidesmosomes and reduce beta4 phosphorylation in a cal

59 regrown epithelium, with re-establishment of hemidesmosomes and reduced scarring and inflammation (CD

60 aling of the skin, keratinocytes disassemble hemidesmosomes and reorganize their actin cytoskeletons

61 (1364) reduced the ability of EGF to disrupt hemidesmosomes and that this effect appears to involve c

62 MUA-3 localizes to the hypodermal hemidesmosomes and to other sites of mechanically robust

63 sin restored desmosomal cell-cell junctions, hemidesmosomes, and BM integrity and epithelial cohesion

64 GFP-beta4WT) into 804G cells, which assemble hemidesmosomes, and human endothelial cells, which expre

65 in the basal keratinocytes that connected to hemidesmosomes, and on the dermal side both collagen fil

66 , as seen by a nearly complete lamina densa, hemidesmosomes, and the polarized, linear distribution o

67 d keratinocytes reveals abundant desmosomes, hemidesmosomes, and the production of a basal lamina.

68 structural functions, invertebrate and human hemidesmosomes are actively monitored by the cell as a n

69 Hemidesmosomes are cellular attachment structures of gre

70 Because hemidesmosomes are involved not only in keratinocyte-ext

71 alized cell junctions such as desmosomes and hemidesmosomes are mediated through the so-called plakin

72 Hemidesmosomes are multiprotein structures that attach e

73 Hemidesmosomes are specialized cell-matrix adhesion stru

74 Desmosomes and hemidesmosomes are the major cell surface attachment sit

75 , the alpha6beta4 integrin is mobilized from hemidesmosomes as evidenced by indirect immunofluorescen

76 Our results reveal a novel role for hemidesmosomes as regulators of cellular mechanical forc

77 The absence of plectin in the hemidesmosomes, as reflected by negative immunofluoresce

78 alpha6beta4 integrin plays a crucial role in hemidesmosome assembly by binding to laminin-5 in the ba

79 Hemidesmosome assembly emerged as a key pathway in our a

80 onally, increased tension caused by impaired hemidesmosome assembly leads to a redistribution of inte

81 ilitates basement membrane assembly, but not hemidesmosome assembly, in the laminin 5-rich dermal-epi

82 ts in enhanced wound healing while promoting hemidesmosome assembly.

83 LAMB3, and LAMC2), in the gene encoding the hemidesmosome-associated beta4 integrin (ITGB4), and in

84 Future work targeting hemidesmosome-associated protein modifications may preve

85 nificant post-translational modifications to hemidesmosome-associated proteins develop in airway epit

86 for changes in abundance and distribution of hemidesmosome-associated proteins following DA exposure

87 es nor for the localization of other cIFs or hemidesmosome-associated proteins in the embryo.

88 ulted in post-translational modifications to hemidesmosome-associated proteins with KRT5 crosslinking

89 dermal blisters and autoantibodies against 2 hemidesmosome-associated proteins, BP180 and BP230.

90 tribution and relative abundance of multiple hemidesmosome-associated proteins, including keratin 5 (

91 tal abundance and perinuclear aggregation of hemidesmosome-associated proteins.

92 collagen as a transmembrane component of the hemidesmosomes at the dermal/epidermal junction.

93 beta 4 couple with BPAG1-e and BPAG2 to form hemidesmosomes, attaching externally to laminin and inte

94 In short, an apical ES-BTB-hemidesmosome autocrine regulatory axis was identified i

95 rin alpha6beta4 is an essential component of hemidesmosomes but it also plays a dynamic role in invas

96 atment does not induce increased assembly of hemidesmosomes, but instead causes a deterioration of th

97 suggest that the EGF-R causes disassembly of hemidesmosomes by activating Fyn, which in turn phosphor

98 lso the disruption of alpha6beta4-containing hemidesmosomes by protein kinase C.

99 80 and certain cytoplasmic components of the hemidesmosome colocalize in the peptide-treated cells, t

100 In the skin, laminins are part of a hemidesmosome complex essential for basal keratinocyte a

101 Analysis of the hemidesmosome component alpha6beta4 indicated that norma

102 Nonetheless, the transmembrane hemidesmosome component collagen XVII (ColXVII) is found

103 s is the first crystal structure of either a hemidesmosome component or an integrin cytoplasmic domai

104 olecule and compared it to the transmembrane hemidesmosome component, alpha 6 beta 4 integrin, and to

105 Phosphorylation of the beta4 integrin, a hemidesmosome component, induces disassembly.

106 Both UNC-52 and hemidesmosome components exhibited highly regular stripe

107 We propose that just as hemidesmosomes connect the dorsal and ventral epidermis,

108 d by keratinocytes and is a key component of hemidesmosomes connecting the keratinocytes to the under

109 re mediated by a mechanical feedback loop of hemidesmosome-containing structures that span from the e

110 We propose that the Ab-mediated loss of hemidesmosomes could weaken attachment of basal keratino

111 essed as a percentage of the total number of hemidesmosomes counted.

112 s BP230) is a member of the plakin family of hemidesmosome cytoskeletal linker proteins that is encod

113 Furthermore, desmosome and hemidesmosome defects were identified in the skin of FA

114 cells produce lamellae, their basal type II hemidesmosomes disappear and the alpha6 integrins appear

115 Epidermal growth factor (EGF) can induce hemidesmosome disassembly by a mechanism that involves s

116 the mechanism and functional significance of hemidesmosome disassembly during normal epithelial cell

117 siRNA increase beta4 phosphorylation, induce hemidesmosome disassembly, and increase migration in HaC

118 serine phosphorylation in regulating type II hemidesmosome disassembly, implicate a cluster of serine

119 Stratified tissues are devoid of hemidesmosomes, display only a very fragile attachment t

120 Hemidesmosome dynamics are altered downstream of epiderm

121 Although the regulation of hemidesmosome dynamics during processes such as epitheli

122 reduces beta4 phosphorylation and stabilizes hemidesmosomes, effects that are reversed by CsA, indica

123 lation of alpha6 or beta4 results in loss of hemidesmosomes, epidermal polarity, and basement membran

124 0-kDa alpha(3) subunit efficiently nucleates hemidesmosome formation and reduces cell motility.

125 partic acid mutation of beta4 T1736 impaired hemidesmosome formation in junctional epidermolysis asso

126 er, the component responsible for initiating hemidesmosome formation remains unknown.

127 This failure of hemidesmosome formation results in a less stable epithel

128 luated by immunofluorescence microscopy, and hemidesmosome formation was assessed by electron microsc

129 lance of beta1 and beta4 integrin signaling, hemidesmosome formation, and laminin production were inf

130 Accordingly, clint1 mutants show impaired hemidesmosome formation, loss of cell-cell contacts and

131 iated by the BP epitope but is necessary for hemidesmosome formation.

132 protein, impedes wound healing but inhibits hemidesmosome formation.

133 t mimic constitutive phosphorylation reduced hemidesmosome formation.

134 Although the adhesion function of hemidesmosomes has been extensively studied, their role

135 Hemidesmosomes (HDs) are epithelial-specific cell-matrix

136 Hemidesmosomes (HDs) are multiprotein structures that an

137 (LN332) receptor central to the formation of hemidesmosomes in epithelial layers.

138 d basement membrane is responsible for fewer hemidesmosomes in the Klf4CN cornea.

139 re not affected even though there were fewer hemidesmosomes in the Klf4CN corneas.

140 Some tracks organize hemidesmosomes in the overlying epidermis.

141 BP230 N terminus in 804G cells that assemble hemidesmosomes in vitro.

142 ent adhesion molecules, whereas those in the hemidesmosome include the integrin class of cell matrix

143 The resultant hemidesmosome instability or loss would suggest a less s

144 massive failure of BM assembly/organization, hemidesmosome instability, and a failure of hair follicl

145 c migration of carcinoma cells that assemble hemidesmosomes involves the activation of a signaling pa

146 The hemidesmosome is a multimolecular complex that integrate

147 6beta4, the primary transmembrane protein of hemidesmosomes, is also expressed in the lens, but in th

148 ds to assess certain morphologic features of hemidesmosome-keratin intermediate filaments interaction

149 further assess the role of beta1-integrin in hemidesmosome, knockdown of beta1-integrin in Sertoli ce

150 The appearance of mature hemidesmosomes lags still further.

151 ion of adhesion molecule BP180 and defective hemidesmosomes, leading to detachment of corneal epithel

152 abilizes laminin 5 and engages cells to form hemidesmosome-like junctions in response.

153 rich in mitochondria and had desmosome- and hemidesmosome-like junctions with other axons and retina

154 In C. elegans, assembly of hypodermal hemidesmosome-like structures called fibrous organelles

155 contrast, alpha6beta4C expressed only within hemidesmosome-like structures containing BP180.

156 IL-8 production and decreasing the number of hemidesmosomes localized at the basement membrane zone.

157 These results suggest that disruption of hemidesmosomes mediated by Fyn is a prerequisite for nor

158 lexes and a decrease of 44% in the number of hemidesmosomes/microm of membrane from samples prepared

159 At DA concentrations >= 8.6 mM, these hemidesmosome modifications persist in culture.

160 ne phosphorylation of beta4 and disrupts the hemidesmosomes of 804G cells expressing recombinant wild

161 fect incorporation of alpha(6)beta(4) in the hemidesmosomes of 804G cells.

162 rts a decreasing degree of inhibition on the hemidesmosomes of cells expressing versions of beta(4) c

163 that traverses the lamina lucida beneath the hemidesmosomes of epidermal cells and functions to link

164 UNC-52/Perlecan linked the dense body to the hemidesmosome on the hypodermal cells, which in turn ins

165 Mature hemidesmosomes, once present, have a low turnover rate.

166 rotubules were essential for elongation when hemidesmosomes or the activity of the Rho kinase LET-502

167 Plectin localization and hemidesmosome organization are unaffected in rodless ple

168 MUP-4 colocalizes with epithelial hemidesmosomes overlying body wall muscles, beginning at

169 14 days of age, although the total number of hemidesmosomes per microm of epithelial plasmalemma was

170 A major component of the hemidesmosome plaque is the 230-kDa bullous pemphigoid a

171 focal contact area is increased by 25%, and hemidesmosome proteins are mislocalized.

172 In the same cells, hemidesmosome proteins arrange in cat paw patterns, more

173 the actin cytoskeleton, focal adhesion, and hemidesmosome proteins complexes, thereby modulating cel

174 P-beta4WT and GFP-beta4V284E colocalize with hemidesmosome proteins, whereas hemidesmosomal component

175 pe arising from variants in genes coding for hemidesmosome proteins.

176 In addition, hemidesmosome reformation was also impaired in the beta6

177 rix adhesion complexes, i.e., desmosomes and hemidesmosomes, respectively.

178 Inhibiting focal adhesion kinase or hemidesmosome signaling disrupted acinus formation in IK

179 ajor epidermal integrins are alpha3beta1 and hemidesmosome-specific alpha6beta4; both share laminin 5

180 This, in turn, is required for hemidesmosome stability, epidermal proliferation, and ha

181 primarily on its role in the organization of hemidesmosomes, stable adhesive structures that associat

182 nding of autoantibodies to components of the hemidesmosome structure, resulting in an inflammatory re

183 al epidermal cells via intermediate-filament/hemidesmosome structures.

184 certain critical intracellular functions of hemidesmosomes, such as the normal connections with kera

185 toward a pathogenic epitope on the epidermal hemidesmosome that anchors basal keratinocytes to the ba

186 o those interactions of the molecules of the hemidesmosome that are necessary for its function in int

187 rix protein integral to the formation of the hemidesmosomes that attach normal basal cells to the und

188 surface in structures referred to as type II hemidesmosomes that persist throughout this early stage.

189 lpha 6 beta 4 integrin is a component of the hemidesmosome, the anchoring structure in the basal memb

190 a 6 beta 4 integrin, and to the formation of hemidesmosomes themselves.

191 thogenic rabbit antibody directed toward the hemidesmosome to beta2m-deficient mice and to normal con

192 Using COS-7 cells, which assemble hemidesmosomes type II upon exogenous expression of the

193 atrix (ECM) occur through focal adhesions or hemidesmosomes via the engagement of integrins with fibr

194 ioned whether this intracellular function of hemidesmosomes was also perturbed in junctional epidermo

195 In normal skin 83.3% +/- 3.3 (SEM) hemidesmosomes were associated with keratin intermediate

196 h prominent microvilli, tight junctions, and hemidesmosomes were more pronounced in air-lifted cultur

197 ganized, and anchoring complexes composed of hemidesmosomes were often absent.

198 mbly of cell- matrix adhesive devices called hemidesmosomes when other cells are plated upon them.

199 somes), and pemphigoid antigens are found in hemidesmosomes (which mediate adhesion to the basement m

200 hin keratinocytes; alpha6beta4 is present in hemidesmosomes, while alpha3beta1 is recruited into foca

201 id (BP), is a transmembrane component of the hemidesmosome with a collagen-like extracellular domain.

202 phosphorylation of beta4 and disassembly of hemidesmosomes without interfering with the activation o