ライフサイエンスコーパス: hemin

1 vitro by incubating isolated apoprotein with hemin.

2 ze the adverse physiologic effects of Hb and hemin.

3 ulosis, achieving robust growth with <0.2 uM hemin.

4 or RNA G-quadruplexes (G4) and the cofactor hemin.

5 nd 100 times better than that of unsupported hemin.

6 onferring resistance to the toxic effects of hemin.

7 gastric emptying reversed by the HO1 inducer hemin.

8 e secreted by P. aeruginosa (apo-HasAp) with hemin.

9 77 affected HO-1 levels after induction with hemin.

10 oximately 10(-13) M) of native apoMb (N) for hemin.

11 as similar in media containing hemoglobin or hemin.

12 e HO-1 protein expression in the presence of hemin.

13 sponsive to an environmental signal, such as hemin.

14 its greater ability to acquire host-derived hemin.

15 se pulldown assays showed that Abc3 binds to hemin.

16 in hem15Delta cells cultured in supplemental hemin.

17 apoglobin that is capable of rapidly binding hemin.

18 ocked by PyoG, confirming the role of Hur in hemin acquisition.

19 d treatment at a health care facility and/or hemin administration (median [range] annualized attack r

20 uced by phenylhydrazine-induced hemolysis or hemin administration.

21 uggested that the combination of HNE and low hemin affinity facilitated rapid decomposition of prefor

22 lative importance of apoglobin stability and hemin affinity.

23 to enhance apoglobin stability but decrease hemin affinity.

24 there is little dependence of expression on hemin affinity.

25 overall equilibrium folding constant and not hemin affinity.

26 ngle-molecule redox reaction dynamics at the hemin-Ag interface is primarily driven by thermal fluctu

27 bc3 as vacuolar hemin exporter, results with hemin-agarose pulldown assays showed that Abc3 binds to

28 ther analysis by absorbance spectroscopy and hemin-agarose pulldown assays showed that Shu1 interacts

29 c tumor cell survival assay, SSRBC surrogate hemin, along with H(2)O(2) and ZnPP demonstrate a simila

30 capturing carcinoembryonic antigen (CEA) and hemin, an all-in-one dual-aptasensor with 1,1'-oxalyldii

31 catalyse the NAD(P)H-dependent reduction of hemin, an indication that the protein's role may be to c

32 among all the drugs screened, we found that hemin, an inducer of heme oxygenase, functions as a brea

33 In vivo treatment with hemin, an inducer of HO-1, blocked the vascular hypertro

34 ia and other cell types after treatment with hemin, an iron-containing porphyrin.

35 gic regulator of glomerular DAF and identify hemin analogues as inducers of functional glomerular DAF

36 Hemin analogues differing in either metal or porphyrin r

37 d these results with chemical degradation by hemin and FeCl(3).

38 The sensor consists of hemin and functionalized multi-wall carbon nanotubes cov

39 the surface-exposed HtaA protein binds both hemin and Hb and also contributes to the utilization of

40 within the ChtA CR domain were critical for hemin and Hb binding.

41 61 and H412 were critical for the binding to hemin and Hb by the CR2 domain.

42 ve binding studies demonstrated that soluble hemin and Hb were able to inhibit the binding of HtaA an

43 ChtA, ChtB, and ChtC are able to bind hemin and Hb, with ChtA showing the highest affinity.

44 red proteins, ChtA and ChtC, which also bind hemin and Hb.

45 C. diphtheriae that encode factors that bind hemin and Hb.

46 , HtaB, are required for the ability to bind hemin and Hb.

47 Studies with hemin and heme supplemented medium indicated that antisc

48 Corynebacterium diphtheriae utilizes hemin and hemoglobin (Hb) as iron sources during growth

49 athogen Corynebacterium diphtheriae utilizes hemin and hemoglobin as iron sources for growth in iron-

50 ere respiratory disease diphtheria, utilizes hemin and hemoglobin as iron sources for growth in iron-

51 Plasma levels of hemin and hpx (at admission, day 3, and day 14) were ass

52 Because of the toxicity of high levels of hemin and iron, these compounds are often tightly regula

53 We demonstrated that HbpC binds hemin and localizes to the B. henselae outer membrane an

54 formed from the binding interaction between hemin and the dual DNA aptamer.

55 and facilitate the electron transfer between hemin and the glassy carbon electrode.

56 n without preventing the interaction between hemin and the insoluble matrix of the washed muscle.

57 brain-heart infusion (BHI) supplemented with hemin and vitamin K, and a blend of SHI and BHI, each at

58 diates high affinity binding to ferric heme (hemin) and that its N- and C-terminal domains interact w

59 in binding aptamer recognition complex binds hemin, and the resulting catalytic complex activates the

60 release, and molecular signaling effects of hemin appear to be the most critical.

61 7) autoxidize approximately 8 times and lose hemin approximately 200 times more rapidly than native a

62 ng a dual DNA aptamer (CEA aptamer linked to hemin aptamer), capable of rapidly capturing carcinoembr

63 that membrane disruption and the release of hemin are crucial for the onset of oxidation.

64 It is also known that P. gingivalis requires hemin as an iron source for its growth.

65 V genes resulted in a reduced ability to use hemin as an iron source, while deletion of htaB had no e

66 em was not involved in the uptake and use of hemin as an iron source.

67 ells being unable to grow in the presence of hemin as the sole iron source.

68 atment in a health care facility and/or with hemin, as well as chronic symptoms that adversely influe

69 The insertion of hemin b into the asymmetric environment of a protein poc

70 uadruplex structures and when complexed with hemin become functional DNAzymes.

71 )) and Pseudomonas aeruginosa (HasA(p)) bind hemin between two loops, which harbor the axial ligands

72 to the natural biochromophores chlorophyll, hemin, bilirubin, and biliverdin and to high mass fluoro

73 path for the closing of the His32 loop upon hemin binding and identified molecular motions that are

74 To elucidate the mechanism of hemin binding by Hbp2, we determined crystal structures

75 ion proteins (GST-CR1 and GST-CR2) to assess hemin binding by UV-visual spectroscopy.

76 uctures reveal an unprecedented mechanism of hemin binding in which Hbp2(N2) undergoes a major confor

77 ht previously unrecognized plasticity in the hemin binding mechanism of NEAT domains and provide insi

78 conserved sequences are responsible for the hemin binding property previously ascribed to HtaA.

79 son mutant that constitutively expresses the hemin binding protein C (hbpC) gene.

80 orter PiuBCDA, previously described as an Fe-hemin binding protein, binds tetradentate catechol Fe(II

81 hemin transporter, and the surface-anchored hemin binding proteins HtaA and HtaB.

82 Hemin binding proteins, secretion systems, response regu

83 Hemin binding to the Y75 loop triggers closing of the H3

84 326-D660 with a Y642A mutation that prevents hemin binding).

85 the formation of DNA concatemers containing hemin-binding aptamers through a modified hybridization

86 a series of seven-residue peptides that form hemin-binding catalytic amyloids to facilitate enantiose

87 In this reaction, hemin-binding peroxidase-mimicking DNAzymes ("peroxidyme

88 R) domains within HtaA and in the associated hemin-binding protein, HtaB, are required for the abilit

89 ody of HBs (Ab1) immobilized on the MNPs and hemin bio-bar-coded AuNPs probe labeled antibody (Ab2).

90 (2) The partially unfolded intermediate with hemin bound (IH) has a hemichrome spectrum indicative of

91 A was able to acquire hemin from Hb and that hemin bound to HtaA could be transferred to HtaB.

92 , and unfolded (U) states of apoMb and their hemin-bound counterparts, NH (holoMb), IH, and UH, respe

93 (Hbp2(N2); residues 183-303) in its free and hemin-bound states.

94 hese attacks involves i.v. administration of hemin, but a faster-acting, more effective, and safer th

95 e tumor necrosis factor-alpha receptors, and hemin by abolishing both sEng and soluble fms-like tyros

96 tored uptake of both ferric siderophores and hemin by the pathogens.

97 g electron microscopy, it was indicated that hemin can be successfully incorporated into hemin, graph

98 d lower than that for the native state, free hemin can bind to it and promote the assembly of the hol

99 axial ligand-bearing loops in the process of hemin capture we investigated the H32A mutant, which was

100 Infusion of a low dose of hemin caused acute intravascular hemolysis and autoampli

101 Furthermore, excess NTBI and hemin caused aggregation of PrP(C) to a detergent-insolu

102 Py17XNL, phenylhydrazine and hemin caused premature mobilization of granulocytes from

103 d single-molecule redox reaction dynamics of hemin (chloride) adsorbed on Ag nanoparticle surfaces by

104 ribozyme apoenzyme, which, in complex with a hemin cofactor, catalyzes the color change of the sample

105 , serves as a redox moiety when bound with a hemin cofactor.

106 CEA and hemin competitively bound with the dual DNA aptamer whil

107 unfavored and where the noncovalent DNAzyme-hemin complex has no activity.

108 The G4/hemin complexes catalyze the H(2)O(2)-mediated oxidation

109 ted that formation of synthetic MF6p/FhHDM-1.hemin complexes inhibited hemin degradation by hydrogen

110 on of oxidative-stress-related genes by this hemin concentration-dependent pathway.

111 nt, a decreased temperature and an increased hemin concentration.

112 lizes to the cell surface in response to low hemin concentrations, but under high hemin concentration

113 to low hemin concentrations, but under high hemin concentrations, Shu1-HA4 re-localizes to the vacuo

114 diating the tolerance of B. quintana to high hemin concentrations.

115 gulated when B. quintana was exposed to high hemin concentrations.

116 hemin-limited conditions compared to excess-hemin conditions.

117 d by variation in fatty acid composition and hemin content of the meat, while protein-bound peroxide

118 e Stern-Volmer quenching constants (Ksv) for hemin, cytochrome c, hemoglobin, and myoglobin were 5.6x

119 hetic MF6p/FhHDM-1.hemin complexes inhibited hemin degradation by hydrogen peroxide and hemin peroxid

120 e hcp promoter sequence, and the binding was hemin dependent.

121 Hemin-dependent activation is mediated primarily by the

122 (DPP)Fe(III) cofactor and the zinc metal ion hemin derivative [(PPIX)Zn], underscoring the exquisite

123 bly pathway appears to be dominated by early hemin disassociation events, which leads to the generati

124 mediates, which are important for preventing hemin disassociation from partially unfolded, molten glo

125 ound O2, promotes autoxidation, and enhances hemin dissociation by inhibiting water coordination to t

126 containing aniline, H2O2, and a G-qudraplex-hemin DNAzyme.

127 Because the hemin-doped serum albumin mats have both biocompatibilit

128 the hypothesis that the hemolysis byproduct hemin elicits events that induce ACS.

129 s that the central NEAT domain in Hbp2 binds hemin even though its primary sequence lacks a highly co

130 Consistent with a role for Abc3 as vacuolar hemin exporter, results with hemin-agarose pulldown assa

131 etection of a signal produced in response to hemin exposure.

132 mbly scheme for human methemoglobin, linking hemin (ferric protoporphyrin IX) disassociation and apop

133 d of the four arms which, in the presence of hemin, form catalytic hemin/G-quadruplex DNAzymes with p

134 s demonstrated that HtaA was able to acquire hemin from Hb and that hemin bound to HtaA could be tran

135 ogens secrete a hemophore (HasA) to scavenge hemin from its host and deliver it to a receptor (HasR)

136 pture and extract the oxidized form of heme (hemin) from Hb, IsdH and IsdB.

137 new design of nitric oxide sensors based on hemin-functionalized graphene field-effect transistors.

138 for probing sensing processes that yield the hemin/G-quadruplex as a functional label.

139 nd sensing platform implements the resulting hemin/G-quadruplex as an electrocatalytic label that cat

140 Then, porous Au@Pd nanoparticles and hemin/G-quadruplex as the peroxidase mimics efficiently

141 tasensor based on VEGF-induced assembly of a hemin/G-quadruplex catalyst (detection limit 18 nM).

142 ed assembly of two aptamer subunits into the hemin/G-quadruplex catalyst (detection limit 2.6 nM).

143 ing to the generation of catalytic telomeric hemin/G-quadruplex chains that control the l-cysteine-me

144 anoparticles (MNPs) as supporting matrix and hemin/G-quadruplex DNAzyme as signal amplifier for deter

145 arget DNA present in a sample, by exposing a hemin/G-quadruplex DNAzyme, which then catalyzes the gen

146 This study describes the novel hemin/G-quadruplex DNAzyme-catalyzed aerobic oxidation o

147 Finally, the hemin/G-quadruplex DNAzyme/Amplex Red system was used to

148 ch, in the presence of hemin, form catalytic hemin/G-quadruplex DNAzymes with peroxidase activity.

149 zation of electroactive toluidine blue (Tb), hemin/G-quadruplex formed by intercalating hemin into th

150 n of DNA is further implemented to yield the hemin/G-quadruplex horseradish peroxidase (HRP)-mimickin

151 surface as a result of the formation of the hemin/G-quadruplex label using SPR.

152 The hemin/G-quadruplex nanostructure and the Pb(2+)-dependen

153 the complex and to the self-assembly of the hemin/G-quadruplex on the Au support.

154 Hemin/G-quadruplex structure as HRP mimicking-DNAzyme si

155 e of K(+) ions and hemin, into the telomeric hemin/G-quadruplex structure, exhibiting horseradish per

156 The telomeric hemin/G-quadruplex structures catalyze the oxidation of

157 g recognition events that form the catalytic hemin/G-quadruplex structures.

158 VEGF-induced assembly of a semiconductor QDs-hemin/G-quadruplex supramolecular structure (detection l

159 The hemin/G-quadruplex-aptamer nucleoapzyme also stimulates

160 xy-L-arginine to L-citrulline by a series of hemin/G-quadruplex-arginine aptamer conjugated nucleoapz

161 f the enzymatic activity of AChE through the hemin/G-quadruplex-catalyzed aerobic oxidation of thioch

162 The coupling of a concomitant H2O2-mediated hemin/G-quadruplex-catalyzed oxidation of Amplex Red to

163 of dopamine to aminochrome using a series of hemin/G-quadruplex-dopamine aptamer nucleoapzymes.

164 aptamer can be attached to the surface of a hemin, graphene oxide and multi-walled carbon nanotubes

165 To do this, a ternary nanocomposite of hemin, graphene oxide and multi-walled carbon nanotubes

166 hemin can be successfully incorporated into hemin, graphene oxide and multi-walled carbon nanotubes.

167 Well supported: stable hemin-graphene conjugates formed by immobilization of mo

168 HtaA was unable to bind to Hb from which the hemin had been chemically removed.

169 In cell cultures, this microbe secretes hemin/hemoglobin-binding protein 2 (Hbp2; Lmo2185) prote

170 s better than that of the recently developed hemin-hydrogel system and 100 times better than that of

171 y focuses on how doping the protein mat with hemin improves charge-transport.

172 round signal associated with the use of free hemin in histochemical studies.

173 tion, but no residue from the Q32 loop binds hemin in holo-HasA(yp).

174 ystem and the iron center in the biomolecule hemin in nanometer proximity in a bio-organic/semiconduc

175 ted with the competitive reaction of CEA and hemin in the presence of the dual aptamer, was exponenti

176 ly important in transmitting the presence of hemin in the Tyr75 loop to the His32 loop to initiate it

177 lysis and autoamplification of extracellular hemin in transgenic sickle mice, but not in sickle-trait

178 We demonstrate that Hur can bind to hemin in vitro and that this interaction is blocked by P

179 binding ability of the synthetic protein to hemin in vitro.

180 biomolecule and a solid-state system in the hemin/InAs hybrid structure.

181 Exposure to hemin induced a significant reduction in miR-217 express

182 moglobin-AS) sickle mouse model, intravenous hemin induced cardiovascular collapse and mortality with

183 Exogenous hemin induced Treg polarization in purified T cell/monoc

184 wild-type rats, the natural Hmox substrate, hemin, induced glomerular DAF.

185 egakaryocyte differentiation, but not during hemin-induced erythrocyte differentiation.

186 Furthermore, L3MBTL1 levels decrease during hemin-induced erythroid differentiation or erythropoieti

187 p66Shc knockdown inhibits hemin-induced erythroid differentiation, in which reacti

188 Hemin-induced expression of PlGF is abolished in EKLF-de

189 lterations in leukocyte recruitment, whereas hemin-induced inflammation occurred over a longer time f

190 these results show that Shu1 undergoes rapid hemin-induced internalization from the cell surface to t

191 We now demonstrate heme-bound iron (hemin) induces PlGF mRNA >200-fold in a dose- and time-d

192 n renal epithelial (HK-2) cells demonstrated hemin-inducible chromatin looping between the intronic e

193 4 and hemopexin replacement therapy prior to hemin infusion protected sickle mice from developing ACS

194 , more rapidly and effectively than a single hemin infusion.

195 Heme oxygenase (HO) cleaves hemin into biliverdin, iron, and CO.

196 The incorporation of hemin into the G-quadruplex structure of DNAzyme yields

197 , hemin/G-quadruplex formed by intercalating hemin into the TB aptamer (TBA) and glucose oxidase (GOx

198 that fold, in the presence of K(+) ions and hemin, into the telomeric hemin/G-quadruplex structure,

199 The use of hemin iron by Corynebacterium diphtheriae requires the D

200 The use of hemin iron in C. diphtheriae involves the dtxR- and iron

201 le mutant exhibits a significant decrease in hemin iron use, indicating a role in hemin transport for

202 Hemin iron utilization assays using various C. diphtheri

203 ssays showed that Y361 was essential for the hemin iron utilization function of HtaA.

204 rce, while deletion of htaB had no effect on hemin iron utilization in C. diphtheriae.

205 b and also contributes to the utilization of hemin iron.

206 The binding of free hemin is characterized by an initial rapid phase forming

207 echanism of lung injury due to extracellular hemin is independent of SCD.

208 m of hemin uptake in C. diphtheriae in which hemin is initially obtained from Hb by HtaA and then tra

209 stability of the N state or its affinity for hemin is reduced.

210 lthough the affinity of the intermediate for hemin (K(d) approximately 10(-11) M) is approximately 10

211 me (either intrinsic or added in the form of hemin) led to a further enhancement of thiol-stimulated

212 ne was enhanced in P. gingivalis grown under hemin-limited conditions compared to excess-hemin condit

213 In this study, we found that a hemin-limited growth environment significantly enhanced

214 Hence, to investigate the effect of hemin loading on the topology of the His32 loop we also

215 direct experimental evidence indicating that hemin loads onto the Tyr75 loop of apo-HasAp, which trig

216 exhibit different rates of autoxidation and hemin loss.

217 n intron 1 of the HO-1 gene, which regulates hemin-mediated HO-1 gene expression.

218 rized NEAT domains to coordinate iron in the hemin molecule.

219 r of the redox state of the iron center in a hemin molecule.

220 s are linked by cofacial interactions of two hemin molecules and that the conformation of the Ala32 l

221 nteraction allows reliable immobilization of hemin molecules on graphene without damaging the graphen

222 ution from electron hopping between adjacent hemin molecules to be isolated.

223 0-fold via electron hopping between adjacent hemin molecules, resulting in the highest measured condu

224 -mimicking DNAzymes was stimulated by adding hemin molecules.

225 hat in response to the RBC breakdown product hemin, monocyte control of T cell polarization will diff

226 Our results suggest a mechanism that excess hemin of beta-thalassaemia patients is a significant cau

227 of antibody and alkylthiol/G-quadruplex DNA/hemin on gold nanoparticles was used as bio-bar-coded na

228 ugates formed by immobilization of monomeric hemin on graphene, showed excellent catalytic activity,

229 The interference quantifies the influence of hemin on the spin decoherence properties of the surface

230 on between the apo- and holo-structures, the hemin on-rate is too fast to detect by conventional stop

231 Induction of HO-1 by hemin or CoPP in vitro reduced production of IFN-gamma a

232 fect on the ability of C. diphtheriae to use hemin or Hb as iron sources; however, a chtB htaB double

233 iron and activated by a heme source, such as hemin or Hb.

234 vated by the ChrAS system in the presence of hemin or hemoglobin, and mutations in the chrSA genes ab

235 However, the presence of excess hemin or iron reversed this dominance.

236 tly pirate plant iron compounds such as heme/hemin or iron-nicotianamine, and our data indicate that

237 be cells, their ability to acquire exogenous hemin or the fluorescent heme analog zinc mesoporphyrin

238 d hemin degradation by hydrogen peroxide and hemin peroxidase-like activity in vitro.

239 Reduced hemin, (PPIX)Fe(II), was also employed to highlight the

240 M-1 interact in vitro with cell membranes in hemin-preconditioned erythrocytes.

241 Importantly, hemin primarily through its effect on CD16+ monocytes in

242 te attacks, with 52 (46%) patients receiving hemin prophylaxis.

243 For mammalian HOs, both native hemin propionates are required for substrate binding and

244 efficiencies that rival those of engineered hemin proteins.

245 Hemin, prototypical for the heme group in hemoglobin, is

246 t alpha chain folding intermediates prior to hemin reduction and incorporation into adult Hemoglobin

247 and induced-fit mechanisms that may promote hemin release from Hb by altering the position of its F

248 space, oxidative and nitric oxide reactions, hemin release, and molecular signaling effects of hemin

249 This was ascribed to hemin, released from metHb, promoting lipid oxidation mo

250 ious cycle, B. quintana transitions from the hemin-restricted human bloodstream to the hemin-rich bod

251 role in the adaptation of B. quintana to the hemin-rich arthropod vector environment.

252 he hemin-restricted human bloodstream to the hemin-rich body louse vector.

253 studies suggest that the natural Hb and the hemin-scavenger proteins Hp and hemopexin have a strong

254 BACH1 depletion by shRNA or degradation by hemin sensitizes cells to ETC inhibitors such as metform

255 ore, in vitro studies show that the graphene-hemin sensors can be used for the detection of nitric ox

256 Our studies demonstrate that the graphene-hemin sensors can respond rapidly to nitric oxide in phy

257 Our work supports a model in which hemin serves as a signal for the regulation of OxyR acti

258 emistry measurements of the metalloporphyrin hemin showing shifts of the iron oxidation marker band n

259 is found to increase with temperature due to hemin, signifying a spin exchange between the iron cente

260 nzyme activity compared with non-transfected hemin-stimulated controls.

261 he use of an alternative iron source such as hemin, suggesting an additional inhibitory mechanism ind

262 s showed that both domains were able to bind hemin, suggesting that the conserved sequences are respo

263 O, wild-type V. fischeri grew more slowly on hemin than a hnoX deletion mutant.

264 requiring a 200-fold higher concentration of hemin to achieve growth equivalent to that of its parent

265 (b) The addition of hemin to antiparallel G-quadruplex DNAzymes lead to a bl

266 ing as an Hb-binding hemophore that delivers hemin to other Hbp2 proteins that are attached to the ce

267 n transfer from the Fe(III)/Fe(II) couple of hemin to the carbon surface at -0.370 V and -0.305 V vs.

268 y linked to its catalytically active moiety, hemin, to avoid the high background signal associated wi

269 HrtAB system is required for protection from hemin toxicity and that expression of the hrtAB genes is

270 e reviews the principal mechanisms of Hb and hemin toxicity in different disease states, updates how

271 ved in the protection of C. diphtheriae from hemin toxicity.

272 The results of hemin transfer experiments are consistent with Hbp2 func

273 Hemin transfer experiments demonstrated that HtaA was ab

274 ease in hemin iron use, indicating a role in hemin transport for HtaB and ChtB.

275 s study, we examined the Corynebacterium hmu hemin transport region, a genetic cluster that contains

276 1 Type 3 Secretion System and its effectors, hemin transport, and the two-component system PhoPQ.

277 nes encoding a previously described ABC-type hemin transporter and three additional genes, which we h

278 ae requires the DtxR- and iron-regulated ABC hemin transporter HmuTUV and the secreted Hb-binding pro

279 hmu hemin uptake locus, which encodes an ABC hemin transporter, and the surface-anchored hemin bindin

280 enotype and restores metformin resistance in hemin-treated cells and tumours(7).

281 (low Treg/high Th1) in SCD, was dampened in hemin-treated stimulated monocytes from non-alloimmunize

282 mitochondrial localization, is increased by hemin treatment, but p66Shc remains exclusively in the c

283 leukemia cells treated with the HbF inducers hemin, trichostatin A, and sodium butyrate had significa

284 rred between surface-anchored proteins, with hemin ultimately transported into the cytosol by an ABC

285 en the 11-MUA-Au NDs and the Fe(II) atoms of hemin units, was supported by an increase in the signals

286 are consistent with a proposed mechanism of hemin uptake in C. diphtheriae in which hemin is initial

287 ae involves the dtxR- and iron-regulated hmu hemin uptake locus, which encodes an ABC hemin transport

288 onses in P. gingivalis include regulation of hemin uptake systems and gingipain activity, processes t

289 Both receptors rapidly extract hemin using a conserved tri-domain unit consisting of tw

290 Ten of these, including hemin-utilization genes, have a promoter with a putative

291 nential phase reciprocally shortened as more hemin was bound to the insoluble matrix of WCM.

292 tolerance of H(2)O(2) was also enhanced when hemin was limited in the growth medium of P. gingivalis.

293 y the affinities of the apoglobin states for hemin were allowed to vary.

294 fractions of unfolded apo subunits and free hemin, which are known to damage the integrity of blood

295 Hemin, which protects graphene nanosheets, also serves a

296 iphtheriae produced increased sensitivity to hemin, which was complemented by a plasmid harboring the

297 While hemin, wild-type myoglobin, and other hemoproteins are u

298 bserved that synthetic MF6p/FhHDM-1 binds to hemin with 1:1 stoichiometry and an apparent Kd of 1.14

299 een replaced with Ala residues fails to bind hemin with high affinity.

300 sional (1)H NMR of NmHO azide complexes with hemins with selectively deleted or rearranged propionate

301 ldown assays showed that Shu1 interacts with hemin, with a KD of approximately 2.2 mum.