ライフサイエンスコーパス: hemizygous

1 iency phenotypes (increased growth rate when hemizygous).

2 e ancestral W female sex chromosome), and is hemizygous.

3 e examine the pathogenetic impact of somatic hemizygous 13q12.2 microdeletions in B-cell precursor (B

4 enital-anomaly disorders caused by a de novo hemizygous 22q11.2 deletion mediated by meiotic nonallel

5 The recurrent hemizygous 22q11.2 deletion, associated with 22q11.2 del

6 A total of 829 patients with a confirmed hemizygous 22q11.2 deletion, recruited through 12 intern

7 se reports of parkinsonism co-occurring with hemizygous 22q11.2 deletions and the associated multisys

8 iduals with this syndrome possess 1.5-3.0 Mb hemizygous 22q11.2 deletions.

9 e of stc1 was 2-fold lower when flanked by a hemizygous 25-kb retrotransposon cluster.

10 We found 28% to 45% hemizygous and 15% to 57% homozygous deletions of the OL

11 Pl-OGT hemizygous and EPS male placentas showed similar robust

12 Hemizygous and homozygous deletions in cell lines/xenogr

13 ocus heterozygotes develop as females, while hemizygous and homozygous eggs develop as haploid and di

14 Deletions (hemizygous and homozygous) of GPx3 gene are frequent in

15 rotein are decreased in HDL2 brain, and Jph3 hemizygous and null mice exhibit abnormal motor function

16 Notably, clinical isolates are often EFG1 hemizygous and thus licensed to undergo this transition.

17 PDAPP hemizygous and wild-type littermate control mice were ex

18 he gain-of-function Su(z)2(1) allele but are hemizygous and, in some cases, homozygous viable.

19 In the other, most intergenic insertions are hemizygous and, thus, incapable of homologous recombinat

20 ted pathogenic PID variants (1 homozygous, 5 hemizygous, and 35 heterozygous) found in 35/176 (20%) p

21 Compared with p53 wild-type animals, p53 hemizygous animals had early onset of lesions and a pron

22 male, and individuals that are homozygous or hemizygous are male.

23 We bred NOD mice hemizygous at both TCRalpha and beta (TCRalpha(+/-) beta

24 and grip force were lower in homozygous and hemizygous Berkley mice (BERK and hBERK1, respectively)

25 CI 0.86-1.11; p=0.82) or homozygous girls or hemizygous boys (0.93, 0.82-1.04; p=0.25), with the sole

26 no evidence for protection among G6PD c.202T hemizygous boys and homozygous girls (OR 1.18, 0.99-1.40

27 kg once daily for 3 days), 95 G6PD-deficient hemizygous boys, 24 G6PD-deficient homozygous girls, and

28 2%) children were either homozygous girls or hemizygous boys.

29 MO2 breast cancer cell line, which harbors a hemizygous BRCA1185delAG mutation.

30 iation in diploid C. albicans cells, as EFG1 hemizygous cells undergo a phenotypic transition inacces

31 Hemizygous ch1p36 deletion was common in LG serous carci

32 ouse embryonic stem cells (ESCs) with nested hemizygous chromosomal deletions, we reveal that ribosom

33 gens with the amount of IL-4 produced in the hemizygous condition falling close to the threshold requ

34 eceptor channel was reduced to less than the hemizygous control and to less than half of the wild-typ

35 nces in this model compared with C57BL/6 and hemizygous controls.

36 Hemizygous Cthrc1 transgenic mice developed normally but

37 In this study, we provide evidence that hemizygous deficiency of KLF2 increased diet-induced ath

38 tly, KIF1Bbeta and DRP1 are silenced in 1p36 hemizygous-deleted neuroblastomas, indicating that dereg

39 This accounts for LOH in both its hemizygous deletion and copy-neutral forms, and does not

40 Whereas hemizygous deletion appears to be responsible for KLF5's

41 indicated that promoter hypermethylation and hemizygous deletion contributed to the down-regulation o

42 zygosity that accrues as gene conversion and hemizygous deletion expose preexisting recessive deleter

43 uish loss of heterozygosity events caused by hemizygous deletion from those that occur by copy-neutra

44 in squamous cell carcinomas detected a novel hemizygous deletion in INPP5A on 10q26.3.

45 -GATA site (T AGATAA: AGCCCC) and found that hemizygous deletion led to an embryonic lethal phenotype

46 eletion syndrome (22qDS), characterized by a hemizygous deletion of 1.5-3 Mb on chromosome 22 at locu

47 c genome rearrangement in TB that caused the hemizygous deletion of 313 genes, including the loss of

48 Hemizygous deletion of a 1.5- to 3-megabase region on ch

49 ychiatric abnormalities and is caused by the hemizygous deletion of a 1.5-3 Mb region of chromosome 2

50 Hemizygous deletion of a variable region on chromosome 1

51 At the premalignant stage, hemizygous deletion of Bif-1 resulted in an increase in

52 Hemizygous deletion of chromosome 1p occurs in approxima

53 aniofacial development are associated with a hemizygous deletion of chromosome 22q11 in humans and in

54 In mice, hemizygous deletion of either Tbx1 or Gnb1l can cause de

55 ssues, we took advantage of the link between hemizygous deletion of human chromosome 22q11.2 and high

56 Hemizygous deletion of its gene has been implicated in s

57 We identified a single case with a hemizygous deletion of MIR223, resulting in the complete

58 However, mice with global hemizygous deletion of Notch1 (N1(+/-)) developed larger

59 Indeed, hemizygous deletion of Notch1 in BM-derived cells leads

60 mouse models of human colorectal cancer with hemizygous deletion of POLR2A.

61 mors that lack intragenic mutations but have hemizygous deletion of PTEN, which includes the promoter

62 We found that hemizygous deletion of Synj1 in the context of a mouse m

63 atment was identified who harbored a somatic hemizygous deletion of the DNA repair gene FANCA and put

64 Hemizygous deletion of the elastin gene (ELN) causes Wil

65 mouse model (Df[h15q13]/+) was generated by hemizygous deletion of the orthologous region and charac

66 Here we find that hemizygous deletion of the PIK3R1 gene encoding p85alpha

67 ation, and immunodeficiency resulting from a hemizygous deletion of the short arm of chromosome 4, ca

68 Hemizygous deletion of the Vps35 gene in mice promoted h

69 In this paper, we show that hemizygous deletion of Vps35 in the Tg2576 mouse model o

70 eletion syndrome (22q11.2DS) carry a de novo hemizygous deletion of ~ 3 Mbp occurring by non-allelic

71 yndrome is a rare genetic disorder caused by hemizygous deletion of ~1.6 Mb affecting 26 genes on chr

72 )-a neurodevelopmental condition caused by a hemizygous deletion on chromosome 22-is associated with

73 neurodevelopment disorder associated with a hemizygous deletion on chromosome 7.

74 s syndrome (WS), a rare disorder caused by a hemizygous deletion on chromosome 7q11.23, including gen

75 22q11DS), the result of a 1.5- to 3-megabase hemizygous deletion on human chromosome 22, results in d

76 Hemizygous deletion promoted anchorage-independent growt

77 the observed 27-40% LOH presents evidence of hemizygous deletion with the remaining allele hypermethy

78 1.2 locus, to levels more than expected by a hemizygous deletion, and we demonstrate that this reduct

79 sus regions and the percentage of homozygous/hemizygous deletions across multiple samples.

80 CDKN1B in 14 of 180 SI-NETs, and we detected hemizygous deletions encompassing CDKN1B in 7 out of 50

81 We screened mutant mice carrying hemizygous deletions of 22q11DS genes and identified hap

82 syndromes have in common a high frequency of hemizygous deletions of chromosome 22q11.2.

83 otably, human high-grade gliomas carry focal hemizygous deletions of the X-linked Huwe1 gene in assoc

84 Our findings reveal that the frequent hemizygous deletions on chromosome 16q present a druggab

85 homozygous autosomal, complex autosomal and hemizygous deletions on the X chromosome of probands.

86 rier mutations, we identified homozygous and hemizygous deletions potentially causative for recessive

87 ber of probes for genomic amplifications and hemizygous deletions that were initially detected by Rep

88 ed aberrations include homozygous deletions, hemizygous deletions, copy-neutral LOH, duplications, an

89 umor suppressors are part of large recurrent hemizygous deletions, such as the common chromosome 16q

90 rcinomas analyzed, 3 (13%) have somatic KLLN hemizygous deletions, with somatic loss of the wild-type

91 with cancer-relevant properties within these hemizygous deletions.

92 ss consequences versus matched S. cerevisiae hemizygous diploids.

93 Liver tissues from mice with liver-specific hemizygous disruption of Ppargc1a placed on an obesogeni

94 patients with heterozygous TERT mutations or hemizygous DKC1 mutations, these 2 homozygous TERT patie

95 e resulting fitted models are applied to the hemizygous donors, one model (the one with the positive

96 these studies in wild-type C57BL/6 mice and hemizygous Drd1a-td Tomato (D1-Tmt), Drd1a-eGFP (D1-GFP)

97 When transmitted from a hemizygous father (+/Tg), the Xist Tg demonstrates pater

98 Ovaries of Tgkd/+ hemizygous female mice exhibit defects in luteinization,

99 ne result in Incontinentia Pigmenti in human hemizygous females.

100 Homozygous and hemizygous flies with each allele are viable and fertile

101 ated FLT3/ITD homozygous (FLT3(ITD/ITD)) and hemizygous (FLT3(-/ITD)) mice.

102 Tumors exhibit numerous recurrent hemizygous focal deletions that contain no known tumor s

103 As F(1) hybrid males hemizygous for a D. mauritiana (or D. simulans) X chromo

104 ed Tconv clones from a female subject who is hemizygous for a null mutation in FOXP3, allowing the co

105 Recently, using mice hemizygous for a site-directed VDJH and VJkappa transgen

106 11 (g.73664C > T c.1846C > T p.Arg616*) and hemizygous for a transition mutation in Exon 6 of Nance-

107 had ultralow frequency but existed in males hemizygous for ACE2.

108 except at the test locus, which is rendered hemizygous for alternative alleles from the two parental

109 Plants that are hemizygous for AtLETM2 and homozygous for Atletm1 (letm1

110 nd related phenotypes of db/db mice that are hemizygous for both NSE-LEPR-B and SYN-LEPR-B transgenes

111 Mice hemizygous for C/EBPalpha displayed an intermediate-enha

112 odeletion syndrome (15q13.3DS) are typically hemizygous for CHRNA7, the gene coding for the alpha7 ni

113 that did not express Cre (Cre(0/0)) or were hemizygous for Cre (Cre(+/0)).

114 Here we show that juvenile mice hemizygous for Cyfip1 have altered presynaptic function,

115 uals derived from these inbred lines will be hemizygous for each of these non-allelic homologs but RI

116 Double knockout (KO) mutants that are hemizygous for either aapt1 or aapt2 display impaired po

117 onin neurons are genetically deleted in mice hemizygous for ePet1-Cre and homozygous for floxed Lmx1b

118 olving immature vessels was observed in mice hemizygous for Grk2 or in animals with endothelium-speci

119 /-) and Enpp1(asj) mice, either wild-type or hemizygous for human ENPP1.

120 sessed APC mobilization and function in mice hemizygous for knockout of the insulin receptor (IRKO) a

121 ncing confirms that the heterogametic sex is hemizygous for most sex-linked genes.

122 le explanations for lethality of human males hemizygous for null alleles of FLNA.

123 ial cells of mice that were Brca1 mutant and hemizygous for p53 increased the percentage of mice exhi

124 investigated using Brca1(f/f;MMTV-Cre) mice hemizygous for p53.

125 ine model and fibroblasts from XLID patients hemizygous for PLP2-(-113C>A).

126 uppressing the expression of EphB4; PV cells hemizygous for Pten show an approximately 2-fold increas

127 ly, we estimate that typical individuals are hemizygous for roughly 30-50 deletions larger than 5 kb,

128 further revealed that undifferentiated ESCs hemizygous for Rps5 showed reduced expression levels of

129 Thymocytes from mice hemizygous for the CD8 transgene have a less severe rear

130 Some individuals are hemizygous for the Crs-1 locus, indicating major haploty

131 dually lost in diploid strains, which become hemizygous for the destabilized chromosome.

132 , the use of inbred strains of mice that are hemizygous for the Drd2 BAC transgene provides a reliabl

133 ccurred in 5 patients, of which 3 males were hemizygous for the G6PD-Mahidol mutation.

134 Kernels hemizygous for the gamma-zein deletion had intermediate

135 However, most lines are hemizygous for the insertion, necessitating a genotyping

136 We cloned genomic DNA from two males hemizygous for the long and short repeats of the microsa

137 The TgM83(+/-) mice that were hemizygous for the mutant transgene did not develop spon

138 nic animals that were homozygous rather than hemizygous for the Sp2 transgene exhibited a striking ar

139 Several F1 populations hemizygous for the synthRBCSB1 gene cluster gave rise to

140 resulting in yellow (ch-42) sectors that are hemizygous for the trait of interest.

141 Mice that were hemizygous for the transgene with CRP levels of 9 microg

142 10 mo of age, uninoculated TgM83(+/-) mice (hemizygous for the transgene) remain healthy.

143 d strains of mice (C57BL/6, FVB/N) that were hemizygous for the transgene, the Drd2-eGFP BAC transgen

144 single SNP (rs721575) and their parents were hemizygous for this marker.

145 Mice hemizygous for transgenic expression of human IAPP did n

146 Humans homozygous or hemizygous for variants predicted to cause a loss of fun

147 sex determination) locus, whereas males are hemizygous (from unfertilized eggs).

148 x invasion are enzymatically normal, even in hemizygous G6PD-Mahidol G487A mutants; thus, allowing th

149 We found that hemizygous gamma-TuSC mutants exhibit higher rates of ch

150 rtnering subunits, which was not seen in the hemizygous gene deletion control.

151 Three hemizygous genes appear to determine S-morph characteris

152 ome-wide transcriptional consequences of the hemizygous genomic microdeletion at chromosome 7q11.23.

153 w that dispensable genes are associated with hemizygous genomic regions affected by structural varian

154 The hemizygous genotype had no effect on either acquisition

155 of the csd gene determine femaleness, while hemizygous genotypes (single specificity) determine male

156 comparing phenotypes between homozygous and hemizygous hA-transgenic mice.

157 Mice that are 53bp1 deficient or hemizygous have an increased incidence of lymphoid malig

158 identify rare and intragenic homozygous and hemizygous (HMZ) deletions that may represent complete l

159 ess, a specific facial nerve hypomorphism in hemizygous Hoxb1(A1/-) mice and decreased viability in h

160 inue to collapse the homozygous (i.e., A/A), hemizygous (i.e., A/0), and duplicative (i.e., A/A/A) ge

161 Both genes are hemizygous in Jacobsen syndrome, an 11q contiguous gene

162 The homozygous (or hemizygous in males) CLDN2 genotype confers the greatest

163 e fused to the ancestral X chromosome and is hemizygous in males.

164 osomes show male-biased inheritance) and are hemizygous in the heterogametic sex.

165 monary tumorigenesis was also accelerated by hemizygous inactivation of Lkb1.

166 t cleavage results in chromosomal losses and hemizygous indels because of cleavage of both alleles.

167 Hemizygous insertion of Gp1ba promoter-driven human alph

168 The tubules of hemizygous KitL(L263A/Sl) mice completely lack germ cell

169 elogenesis, we generated and characterized a hemizygous knockin (KI) mouse model with a phosphorylati

170 erve a significant 1.5-fold increase in rare hemizygous knockouts in males, contributing to another 2

171 his study, we tested whether variants in the hemizygous LCR22A-D region are associated with risk for

172 ic ablation of Atp6ap2 resulted in both male hemizygous lethality and female haploinsufficiency.

173 as the remaining lines caused homozygous and hemizygous lethality.

174 ion of mitochondrial proteins was reduced in hemizygous (letm1(-/-) LETM2(+/-)) plants.

175 as heritable and gene dosage dependent, with hemizygous lines showing intermediate HFA levels.

176 critical for normal cognitive function; its hemizygous loss is linked to the severe mental retardati

177 example, breakpoints leading to large-scale hemizygous loss of chromosome 11q were highly clustered

178 cent studies have revealed downregulation or hemizygous loss of Dicer in many tumor models and demons

179 In comparison, hemizygous loss of Dicer in the same model also reduces

180 We confirmed hemizygous loss of Faf1 and down-regulation of Faf1 prot

181 Hemizygous loss of ID4 in nontransformed TCL1-positive B

182 Although we have previously shown that hemizygous loss of RPS14 recapitulates the failed erythr

183 y, rare human prostate cancer samples showed hemizygous loss of the COP1 gene, loss of COP1 protein,

184 u syndrome (PTS) seems to occur by virtue of hemizygous loss of the FLI1 transcription factor gene.

185 tion driving aberrant MYB-QKI expression and hemizygous loss of the tumor suppressor QKI.

186 We identified a 99-kb hemizygous loss on chromosome Xq13.2 that involved three

187 m to complete IL-4Ralpha(-/-) mice to obtain hemizygous LysM(cre)IL-4Ralpha(flox/-) mice.

188 alphaS homozygous M83 Tg mice and 3-4 mo for hemizygous M83 Tg mice, these animals developed a rapid,

189 oneal (i.p.) injections of alphaS fibrils in hemizygous M83 transgenic (M83(+/-)) mice resulted in CN

190 3-5 months, 7-10 months and 18-20 months) in hemizygous male and heterozygous female mice.

191 e-specific inheritance pattern of FDH, Porcn hemizygous male embryos arrest during early embryogenesi

192 limb strength and exercise capacity in adult hemizygous male mice starting from 7 to 10 months of age

193 Since hemizygous male mice with Nsdhl mutations die by midgest

194 Hemizygous male Mtm1 p.R69C mice develop early muscle at

195 Hemizygous male mutant cells showed a strikingly enhance

196 Thus, adult hemizygous male, but not heterozygous female, mice showe

197 thogenesis of developmental epilepsy in both hemizygous males and carrier females.

198 type I syndrome leading to prenatal death in hemizygous males and dysmorphic faces and brain malforma

199 Nevertheless, Pcdh19 hemizygous males and heterozygous females showed impaire

200 test is applied to the females only, and the hemizygous males are considered to be uninformative.

201 Hemizygous males usually die of neonatal encephalopathy.

202 = 2% in Hispanics) lowered HbA1c (-0.88% in hemizygous males, -0.34% in heterozygous females) and ex

203 76723693, p.Leu353Pro, MAF = 0.5%; -0.98% in hemizygous males, -0.46% in heterozygous females) and de

204 nizable but mild neurocognitive phenotype in hemizygous males.

205 ue boundaries-a process that cannot occur in hemizygous males.

206 and reduced copper content in the brains of hemizygous males.

207 s and is generally lethal (cause unknown) in hemizygous males.

208 and identifiedacorrelation with phenotype in hemizygous males.

209 ndividuals with MDS and AML-in an inducible, hemizygous manner in hematopoietic cells.

210 0.81%-units (95% CI 0.66-0.96) per allele in hemizygous men, and 0.68%-units (95% CI 0.38-0.97) in ho

211 all EGFPf-positive cultured DRG neurons from hemizygous mice (TRPM8(EGFPf/+)) responded to cold and m

212 OPCs from hemizygous mice also undergo precocious differentiation,

213 NF-kappaB essential modulator) are lethal in hemizygous mice and men, whereas hypomorphic alleles typ

214 n which epitope-specific CD8(+) T cells from hemizygous mice had a higher avidity for pMHCI and incre

215 Clic4 hemizygous mice had intermediate deficits in the above p

216 cient operation of the shuttle in the aralar hemizygous mice prevents the protective role of L-lactat

217 oreover, the peripheral T cell repertoire in hemizygous mice showed selective retention of T cell clo

218 ve superiority of CD8(+) T cells retained in hemizygous mice was also seen during influenza A virus i

219 Furthermore, examination of hemizygous mice with a single Taar allele suggests that

220 pheral CD8(+) T cell numbers of ~50% in MHCI hemizygous mice, MHCI levels had no notable impact on th

221 The prediabetes stage was prolonged in the hemizygous mice, wherein beta-cell dysfunction and exten

222 ype AQP2 and AQP2-T126M were bred to produce hemizygous mice, which following excision of the wild-ty

223 homozygous mice and prevented oncogenesis in hemizygous mice.

224 n is absent from tumors arising in p27(Kip1) hemizygous mice.

225 There was no loss of LC neurons in the hemizygous mice.

226 rome (WS), a genetic disorder resulting from hemizygous microdeletion of chromosome 7q11.23, has emer

227 syndrome (WS), a genetic disorder caused by hemizygous microdeletion on chromosome 7q11.23 and chara

228 Williams syndrome, caused by a hemizygous microdeletion on chromosome 7q11.23, is chara

229 drome (WS) is a genetic disorder caused by a hemizygous microdeletion on chromosome 7q11.23.

230 alysis in each family identified overlapping hemizygous microdeletions.

231 We identified 11 male patients with hemizygous missense mutations in ATP6AP1, encoding acces

232 We identified hemizygous missense mutations in the gene TBC1D8B in fiv

233 ically diagnosed with WDSTS; this revealed a hemizygous, missense mutation in SMC1A that was predicte

234 ale embryos were more severely affected than hemizygous mutant male embryos.

235 in by CRISPR-Cas9 mutagenesis and found that hemizygous mutants displayed significant differences in

236 We describe a young male with a hemizygous mutation in the X-chromosome gene FIGF (c.352

237 In addition, hemizygous mutations in GATA2, as well as heterozygous a

238 Here, we report on two hemizygous mutations in OGT in individuals with X-linked

239 Hemizygous mutations in the human gene encoding platelet

240 We observed hemizygous mutations in the moesin (MSN) gene (located o

241 Hemizygous mutations predictive of the absence of WAS pr

242 n we sequenced TET2, we found homozygous and hemizygous mutations.

243 Their hemizygous nature contributes to faster divergence and r

244 noma NCI-H460 cells, which we show contain a hemizygous nonsense mutation in the Arkadia/RNF111 gene,

245 nts and exonic copy number variants, such as hemizygous nonsense, frameshift, and missense changes in

246 We show that thrums are hemizygous not heterozygous for the S locus, which sugge

247 hT17M rhodopsin transgene in a line that was hemizygous null for wild-type mouse rhodopsin (mrho(+/-)

248 ssessments have been conducted in male Mecp2 hemizygous null mice as offspring of heterozygous dams.

249 In addition, transgenic mice hemizygous-null for nm23-m1 and nm23-m2 exhibited UVR-in

250 in the neonatal brain of placental-specific hemizygous OGT mice was substantially altered.

251 The finding of hemizygous or homozygous deletions at band 14 on chromos

252 cer Genome Atlas project, 93 (21%) have KLLN hemizygous or homozygous deletions.

253 Mice with liver-specific hemizygous or homozygous disruption of Ppargc1a (Ppargc1

254 Using mice that are hemizygous or homozygous for a single MHCI allele, we sh

255 Mice hemizygous or homozygous for either knockin allele exhib

256 Here we report hemizygous or homozygous inactivating mutations of the c

257 re dominant and functioned equally well in a hemizygous or homozygous state.

258 iciency phenotypes (reduced growth rate when hemizygous) or haploproficiency phenotypes (increased gr

259 Hemizygous plants displayed a semi-dwarfing phenotype, i

260 growth reduction of tumours characterized by hemizygous POLR2A loss.

261 as expressed at a level approximating normal hemizygous protein output.

262 heterozygous rare variants in autosomes and hemizygous rare variants in the X chromosome of males.

263 In Primula, the S locus is a roughly 300-kb hemizygous region containing five predicted genes.

264 etinograms (ERGs) were recorded from 44 male hemizygous Rs1h-KO and 44 male wild-type (WT) C57BL/6J m

265 Hemizygous s6k1s6k2/++ mutant and S6K1 RNAi lines show h

266 f the intermediate phenotype of functionally hemizygous Scn8a(N1768D/-) mice indicates that severity

267 ng skew in Z genotype was detected in their (hemizygous) sisters.

268 contrast, papillomas formed normally in Chk1 hemizygous skin but showed an increased propensity to pr

269 , heterozygous Sod2-knockout mouse (HET) and hemizygous Sod2 mice with overexpression of the enzyme (

270 ccur for transgenes that are maintained in a hemizygous state for several generations.

271 anel of single-allele knockout strains whose hemizygous state mimics the genes' adaptive down-regulat

272 ncreased lysine in QPM in its homozygous and hemizygous states.

273 ve fitness assays of these pooled, barcoded, hemizygous strains, and accompanying controls, revealed

274 degree of correction in db/db mice that are hemizygous (Syn db/db) and homozygous (Syn/Syn db/db) fo

275 In a first series of experiments using hemizygous tamoxifen-induced genetic inactivation of a f

276 In our study, hemizygous TEX11 mutations were a common cause of meioti

277 GLUD protein and activity in CNS neurons of hemizygous Tg mice were associated with increases in the

278 Study animals were PS19, homozygous and hemizygous Tg(MAPT*P301S), and B6/J mice.

279 Hemizygous Tg-TBK1 mice (with one TBK1 transgene per gen

280 zygous Tg-TBK1 mice had 7.6% fewer RGCs than hemizygous Tg-TBK1 mice and 20% fewer RGCs than wild-typ

281 ghbouring genes, rendering cancer cells with hemizygous TP53 deletion vulnerable to further suppressi

282 ic potential of colorectal cancer cells with hemizygous TP53 loss in a p53-independent manner.

283 at transgene expression can be restored when hemizygous transgenes that were silenced via multigenera

284 mLECs) derived from human IDO-overexpressing hemizygous transgenic (hemTg) and wild-type (Wt) mice we

285 ory hair cells within inner ear epithelia of hemizygous transgenic females due to X inactivation.

286 Hemizygous transgenic mice harboring increased levels of

287 e (nasodigitoacoustic syndrome) identified a hemizygous truncating variant in the gene encoding glypi

288 treatment preferentially upregulated several hemizygous TSG in this genomic region, significantly der

289 nding hypermethylation and gene silencing of hemizygous tumor suppressor genes (TSG), we thus hypothe

290 tumors revealed a common profile among E518K hemizygous tumors.

291 ces within a 200-kb X-linked region, and the hemizygous (unpaired) state of the Xist region promotes

292 , and multiple compound-heterozygous or rare hemizygous variants in children with CTRD.

293 on, we identified four predicted pathogenic, hemizygous variants on chromosome X in two known disease

294 However, Pl' can revert to Pl-Rh when hemizygous, when heterozygous with pl1 alleles other tha

295 y one-quarter were viable when homozygous or hemizygous, whereas the remaining lines caused homozygou

296 73 HMZ deletion calls (567 homozygous or 206 hemizygous) with an estimated sensitivity of 86.5% (82%

297 Hemizygous worms [spe-46(hc197)/mnDf111] are effectively

298 ous recombination to modify a native gene in hemizygous (wt/Deltaexon) human cancer cells, generating

299 o females, due to dosage compensation of the hemizygous X.

300 n is doubled from the single X chromosome in hemizygous (XY) males, whereas in Caenorhabditis nematod