ライフサイエンスコーパス: hemocyanin

1 immunoglobulin conjugated to keyhole limpet hemocyanin.

2 ell and chemically coupled to keyhole limpet hemocyanin.

3 hapten, conjugated to BSA or keyhole limpet hemocyanin.

4 immunized with trinitrophenyl-keyhole limpet hemocyanin.

5 -fold) after conjugation with keyhole limpet hemocyanin.

6 2) mimics the spectroscopic signature of oxy-hemocyanin.

7 -dependent Ag, phosphocholine-keyhole limpet hemocyanin.

8 ow insect hexamerins might have evolved from hemocyanin.

9 ization of male SJL mice with keyhole limpet hemocyanin.

10 nserved copper-binding histidine residues of hemocyanin.

11 reased by conjugating them to keyhole limpet hemocyanin.

12 ITC-labeled tetanus, OVA, and keyhole limpet hemocyanin.

13 equenced lepidopteran hexamerin or arthropod hemocyanin.

14 host-restricted responses to keyhole limpet hemocyanin.

15 against 2,4,6 trinitro-phenyl-keyhole limpet hemocyanin.

16 hed control Ig, conjugated to keyhole limpet hemocyanin.

17 o oligosaccharides present on keyhole limpet hemocyanin.

18 a) with the benchmark carrier keyhole limpet hemocyanin.

19 g dose groups challenged with keyhole limpet hemocyanin.

20 A, as well as to the model Ag keyhole limpet hemocyanin.

21 T cell-dependent (TD) Ag DNP-keyhole limpet hemocyanin.

22 r after immunization with DNP-keyhole limpet hemocyanin.

23 coupled with carrier protein keyhole limpet hemocyanin.

24 T cell-dependent antigen TNP-keyhole limpet hemocyanin.

25 h UO(2)(2+)-DCP conjugated to keyhole limpet hemocyanin.

26 icant homology to the sequences of arthropod hemocyanins.

27 Inhibition of anti-keyhole limpet hemocyanin Ab response was dose-dependent in FR104 recip

28 nitrophenol hapten-conjugated keyhole limpet hemocyanin adsorbed to Imject aluminum hydroxide-contain

29 mmunity to model Ags (OVA and keyhole limpet hemocyanin), affecting all major T-dependent Ig classes,

30 a substantial Ab response to keyhole limpet hemocyanin after completion of anti-CD40L Ab treatment,

31 r, mDCs(ICOS) pulsed with the keyhole limpet hemocyanin Ag during the maturation phase were better st

32 en and secondary responses to keyhole limpet hemocyanin Ag.

33 Hemocyanins also interact with glycan-recognizing innate

34 ion of IgE in response to DNP-keyhole limpet hemocyanin/alum and Nippostrongylus brasiliensis infecti

35 nation with GM2 conjugated to keyhole limpet hemocyanin and administered with QS-21 (GMK) for 96 week

36 hemocyanin in comparison with keyhole limpet hemocyanin and C. concholepas hemocyanin, which was char

37 onses against protein antigen keyhole limpet hemocyanin and carbohydrate antigen sTn, respectively.

38 CD4+ T cell sensitization to keyhole limpet hemocyanin and CD8+ T cell sensitization to MART-1 melan

39 ykynurenine (3OHKYN)-modified keyhole limpet hemocyanin and characterized it using 3OHKYN-modified am

40 nses to two soluble proteins, keyhole limpet hemocyanin and chicken egg albumin.

41 The presence of both hemocyanin and cryptocyanin in one animal provides an ex

42 f tumor Ig protein coupled to keyhole limpet hemocyanin and emulsified in an immunologic adjuvant.

43 immune deviation induced with keyhole limpet hemocyanin and IFA did not affect corneal allograft reje

44 okine-matured DCs loaded with keyhole limpet hemocyanin and MHC-I alone or MHC-I/II-restricted tumor-

45 fferent immunogenic carriers, keyhole limpet hemocyanin and N-alpha-palmitoyl-S-[2,3-bis(palmitoyloxy

46 ponses to the T-dependent Ags keyhole limpet hemocyanin and OVA, as well as reduced Ag-specific B cel

47 duction of antibodies against keyhole limpet hemocyanin and Pneumovax in mice, indicating that APRIL

48 ponse to trinitrophenol (TNP)-keyhole limpet hemocyanin and tetanus/diphtheria vaccine, CD40Ltg+ mice

49 n or trinitrophenylated (TNP) keyhole limpet hemocyanin and the type 2 T-independent Ags TNP-Ficoll o

50 hybridoma, was conjugated to keyhole limpet hemocyanin and used to immunize Balb/c mice by administr

51 was conjugated to the carrier keyhole limpet hemocyanin and used to immunize mice.

52 cyanin is closely associated with crustacean hemocyanins and suggests that cryptocyanin arose as a re

53 en synthesized, conjugated to keyhole limpet hemocyanin, and administered with the immunologic adjuva

54 caffeine covalently linked to keyhole limpet hemocyanin, and recombinant antibody techniques were use

55 were synthesized, coupled to keyhole limpet hemocyanin, and used to produce rabbit antisera.

56 nd immunoblots using anti-AGE-keyhole limpet hemocyanin antibody, aminoguanidine inhibited glucose-in

57 L-selectin-deficient mice to keyhole limpet hemocyanin are indistinguishable from wild-type control

58 n, sarcoplasmic calcium-binding protein, and hemocyanin are the most relevant.

59 Il5 Collectively, our data demonstrate that hemocyanins are able to trigger the release of proinflam

60 Hemocyanins are giant oxygen transport proteins found in

61 Hemocyanins are multimeric copper-containing hemolymph p

62 Hemocyanins are widely used as carriers, adjuvants, and

63 ed after immunization with PC-keyhole limpet hemocyanin but at significantly lower levels than those

64 4-hydroxy-3-nitrophenylacetyl-keyhole limpet hemocyanin, but GrB-deficient mice produced normal amoun

65 igh doses of (4-hydroxy-3-nitrophenyl)acetyl-hemocyanin, but maintenance of affinity maturation.

66 m plasma of mice immunized to keyhole limpet hemocyanin, but not from naive or OVA-immunized mice, we

67 din L-733,560 was conjugated to succinylated hemocyanin by water-soluble carbodiimide and was used as

68 ounterligands (fibrinogen and keyhole limpet hemocyanin) by 50%, but did not affect adhesion to fibro

69 CTL, and development of anti-keyhole limpet hemocyanin CD4+ T cells, rejection of allogeneic or syng

70 phiX 174 and nuclear protein-keyhole limpet hemocyanin) characterized by a reduction in number and s

71 ere defective in adherence to keyhole limpet hemocyanin-coated glass, iC3b-mediated phagocytosis, and

72 MH6, was then contrasted with keyhole limpet hemocyanin conjugate vaccine in a subsequent experiment

73 zed with the native 38C13 IgM-keyhole limpet hemocyanin conjugate vaccine.

74 ], MH6, and MH7) or a control keyhole limpet hemocyanin conjugate vaccine.

75 immunized with a cocktail of keyhole limpet hemocyanin-conjugated peptides corresponding to the AipA

76 cinated with the CD20 peptide keyhole limpet hemocyanin conjugates had a 25% decrease in CD19(+) sple

77 Both keyhole lymphet hemocyanin conjugates induced IgM and IgG antibodies aga

78 ty of three synthetic globo H-keyhole limpet hemocyanin conjugates plus the immunologic adjuvant QS-2

79 as free glycopeptides or as keyhole lymphet hemocyanin conjugates.

80 hetic model that structurally mimics the oxy-hemocyanin core, whereas the Cu(II)(2) protein reacted w

81 ltiple members of the hemocyanin gene family-hemocyanin, cryptocyanin, phenoloxidase, and hexamerins-

82 mmunized with nitrophenylated-keyhole limpet hemocyanin, Dbc1(-/-) mice produce significantly increas

83 immunized with trinitrophenyl-keyhole limpet hemocyanin, dbh-/- mice produced less Th1 cytokine-depen

84 The inhibition of hemocyanin-derived phenoloxidase activity is discussed,

85 unized with PA1 conjugated to keyhole limpet hemocyanin developed high anti-peptide (1/13,000), but l

86 gen, 2,4-dinitrophenyl hapten-keyhole limpet hemocyanin (DNP(23)-KLH).

87 he molt cycle and reaches levels higher than hemocyanin during premolt.

88 red with native hemocyanins N-deglycosylated hemocyanins elicited reduced antibody titers, as well as

89 t from those generated by the keyhole limpet hemocyanin-epitope conjugates.

90 ptide [SLS(10-30)] coupled to keyhole limpet hemocyanin evoked antibodies in rabbits that completely

91 Within some spider lineages, however, hemocyanin evolution has been a dynamic process with ext

92 ion and cytokine secretion by keyhole limpet hemocyanin-experienced CD4(+) T cells.

93 mice with 3H1 conjugated with keyhole limpet hemocyanin Freund's adjuvant induced humoral and cellula

94 Rhodamine and fluorescein-labeled hemocyanin from Megathura crenulata (KLH) were prepared

95 ture of a high molecular weight protein, the hemocyanin from Octopus vulgaris, under solution conditi

96 The results show that the hemocyanin from the mollusc and that from the arthropod

97 ural and immunological properties, including hemocyanins from Concholepas concholepas, Fissurella lat

98 sts that cryptocyanin arose as a result of a hemocyanin gene duplication.

99 rphae in order to infer the evolution of the hemocyanin gene family and estimate spider relationships

100 etween cryptocyanin and other members of the hemocyanin gene family shows that cryptocyanin is closel

101 results suggest that multiple members of the hemocyanin gene family-hemocyanin, cryptocyanin, phenolo

102 We have obtained hemocyanin gene sequences from numerous representatives

103 Our hemocyanin gene tree is largely consistent with the prev

104 the last number of years, the oxygen carrier hemocyanin, has demonstrated several immune- and physiol

105 muscle of Macrobrachium rosenbergii whereas, hemocyanin (HC) was identified as an allergen in Macrobr

106 tertiary, and quaternary structures of squid hemocyanin (Hc) were characterised, and the relationship

107 led binuclear "type 3" Cu sites are found in hemocyanin (Hc), tyrosinase (Tyr), and the multicopper o

108 e the reaction coordinate of O(2) binding to Hemocyanin (Hc).

109 Immunization with DNP-keyhole limpet hemocyanin, heat-killed Brucella abortus, or infection w

110 n, aggrecan, collagen, entactin, fibrinogen, hemocyanin, heparan sulphate, laminin, myosin, proteogly

111 d to immunocyanin monomers of keyhole limpet hemocyanin (IC(KLH)) to create the MCV ICKLH-SOO9.

112 using the standard therapy of keyhole limpet hemocyanin Id + GM-CSF.

113 e immunogenic carrier protein keyhole limpet hemocyanin (Id-KLH).

114 h2 cells, lymphoid cells from keyhole limpet hemocyanin-immune mice bearing healthy corneal allograft

115 rophenyl hapten conjugated to keyhole limpet hemocyanin immunization and nephritis induction.

116 rophenyl hapten conjugated to keyhole limpet hemocyanin immunization resulted in higher affinity 2,4,

117 en-specific IgG1 responses to keyhole limpet hemocyanin immunization, regulated CD4(+) T-cell CD40L e

118 s of Th1 cells in response to keyhole limpet hemocyanin immunization.

119 droxy-3-nitrophenylacetyl/keyhole lymphocyte hemocyanin) immunization.

120 -hydroxy-3-nitrophenyl acetyl-keyhole limpet hemocyanin immunized animals; recall responses were also

121 lper 2 response (ovalbumin or keyhole limpet hemocyanin in alum) and is only seen with T cell-depende

122 fter immunization with OVA or keyhole limpet hemocyanin in CFA, NK cell-deficient (NK-T+) mice develo

123 roinflammatory response for F. latimarginata hemocyanin in comparison with keyhole limpet hemocyanin

124 0,000-mug doses of intranasal keyhole limpet hemocyanin in conjunction with adjuvant intranasal diese

125 s in isopods, we discuss a possible role for hemocyanins in lignin decomposition.

126 Evaluating the function of N-deglycosylated hemocyanins in the humoral immune response and their non

127 e to the T cell-dependent Ag, keyhole limpet hemocyanin, in the PDE7A(-/-) mice was found to be signi

128 Hemocyanins induce a potent Th1-dominant immune response

129 s preclinical models, such as keyhole limpet hemocyanin-induced Ab responses, alloantigen-induced T c

130 Octopus hemocyanin is composed of ten subunits, each of which co

131 e structural and immunological properties of hemocyanin is unclear.

132 In conclusion, the glycan content of hemocyanins is, among other structural characteristics,

133 TCR Id protein conjugated to keyhole limpet hemocyanin (KLH) (TCR Id:KLH) and injected with a chemic

134 gated to the carrier protein, keyhole limpet hemocyanin (KLH) - to be capable of inducing broadly neu

135 ulated the production of anti-keyhole limpet hemocyanin (KLH) Ab, increasing anti-KLH IgG, IgG2a, and

136 ive subcutaneous boosts of Id/keyhole limpet hemocyanin (KLH) administered with adjuvant.

137 ) idiotype (Id) conjugated to keyhole limpet hemocyanin (KLH) and administered with granulocyte-monoc

138 tive was covalently linked to keyhole limpet hemocyanin (KLH) and monophosphoryl lipid A (MPLA) to fo

139 lsed with 2 foreign proteins, keyhole limpet hemocyanin (KLH) and tetanus toxoid (TT), as well as an

140 on with two conjugates, Tn(c)-keyhole limpet hemocyanin (KLH) and Tn(c)-palmitic acid (PAM) with the

141 pic mAb MK2-23, conjugated to keyhole limpet hemocyanin (KLH) as a carrier and given with Bacillus Ca

142 a matrix peptide (Flu-MP) and keyhole limpet hemocyanin (KLH) as control antigens.

143 Subjects were fed keyhole limpet hemocyanin (KLH) before subcutaneous immunization and bo

144 ty, we bound thiolated MEP to keyhole limpet hemocyanin (KLH) by using succinimidyl-4-(N-maleimidomet

145 generated to the glycoprotein keyhole limpet hemocyanin (KLH) can cross-link with reactive carbonyl r

146 on of the glycopeptide to the keyhole limpet hemocyanin (KLH) carrier protein completed the preparati

147 jugated to maleimide-modified keyhole limpet hemocyanin (KLH) carrier protein through backbone Cys re

148 ns plus GM-CSF, or linkage to keyhole limpet hemocyanin (KLH) carrier protein were increasingly poten

149 To solve this problem, the keyhole limpet hemocyanin (KLH) conjugates of a series of GM3 derivativ

150 1-82 alphaS, human betaS, and keyhole limpet hemocyanin (KLH) control proteins induced no symptoms or

151 olunteers were immunized with keyhole limpet hemocyanin (KLH) first orally and then parenterally or o

152 s and the immunogenic protein keyhole limpet hemocyanin (KLH) for 24 h and then combined.

153 ynthesized, and conjugated to keyhole limpet hemocyanin (KLH) for examining its immunogenicity.

154 6OXY(Gly)(4)OH) conjugated to keyhole limpet hemocyanin (KLH) has shown early proof-of-efficacy in ro

155 r immunity induced by s.c. Id-keyhole limpet hemocyanin (KLH) immunization.

156 initrophenol (TNP)-conjugated keyhole limpet hemocyanin (KLH) in a specific pathogen-free environment

157 ith the cocaine immunogen GNC-keyhole limpet hemocyanin (KLH) in preventing cocaine self-administrati

158 uenza matrix peptide (MP) and keyhole limpet hemocyanin (KLH) in two healthy subjects.

159 Mice immunized with the Ag keyhole limpet hemocyanin (KLH) mixed with HKL generated a KLH-specific

160 n cocaine immunoconjugate GND-keyhole limpet hemocyanin (KLH) or with the anti-cocaine mAb GNC92H2 we

161 sing Id chemically coupled to keyhole limpet hemocyanin (KLH) plus granulocyte macrophage colony-stim

162 ed to the immunogenic protein keyhole limpet hemocyanin (KLH) protects mice from tumor challenge with

163 hapten to maleimide-activated keyhole limpet hemocyanin (KLH) provided a PI3P immunogen, which was su

164 e of the transgenic mice with keyhole limpet hemocyanin (KLH) resulted in a decrease in anti-KLH IgG

165 s of inflammation including a keyhole limpet hemocyanin (KLH) study and a collagen-induced arthritis

166 ds demonstrated efficacy in a Keyhole Limpet Hemocyanin (KLH) study in rats, where the blockade of PI

167 jugated to ovalbumin (OVA) or keyhole limpet hemocyanin (KLH) to enhance immunogenicity.

168 ed and covalently linked with keyhole limpet hemocyanin (KLH) to generate Id/KLH.

169 genic foreign carrier protein keyhole limpet hemocyanin (KLH) using glutaraldehyde has shown promisin

170 ing antimyeloma idiotype (Id)-keyhole limpet hemocyanin (KLH) vaccine to vaccine-specific costimulate

171 Keyhole limpet hemocyanin (KLH) was beneficial in earlier studies.

172 and to peptides conjugated to keyhole limpet hemocyanin (KLH) were characterized by their ability to

173 r methods, to protein carrier keyhole limpet hemocyanin (KLH) were studied in mice.

174 mimetics of GXM conjugated to keyhole limpet hemocyanin (KLH) with glutaraldehyde developed Abs to GX

175 (TNP-LPS) or T-dependent (TNP-keyhole limpet hemocyanin (KLH)) Ag.

176 Following challenge with TNP-keyhole limpet hemocyanin (KLH), Ab production in these mice was hapten

177 onjugated to ovalbumin (OVA), keyhole limpet hemocyanin (KLH), and a bis-maleimide; KLH conjugates ar

178 Rats were immunized with keyhole limpet hemocyanin (KLH), and blood samples were taken.

179 n exogenous, nonself antigen, keyhole limpet hemocyanin (KLH), by releasing IL-4 in the microenvironm

180 of a foreign helper protein, keyhole limpet hemocyanin (KLH), can augment the efficacy of tumor lysa

181 ith a single dose of 20 mg of keyhole limpet hemocyanin (KLH), followed by s.c. immunization with KLH

182 gen conjugated to the protein keyhole limpet hemocyanin (KLH), has been in clinical evaluation.

183 eeks later by DCs pulsed with keyhole limpet hemocyanin (KLH), HLA-A*0201-positive restricted influen

184 response to PC conjugated to keyhole limpet hemocyanin (KLH), T15 Id(+) Abs constitute >90% of the s

185 Ab immunization protocol (mAb-keyhole limpet hemocyanin (KLH)-Calmette-Guerin bacillus (BCG), an auto

186 However, keyhole limpet hemocyanin (KLH)-priming of IFN-gko mice readily elicite

187 ultured with HDK-1 T cells (a keyhole limpet hemocyanin (KLH)-specific CD4+ Th1 clone) in the presenc

188 tective clone (N-MoPn), and a keyhole limpet hemocyanin (KLH)-specific cell line (KLH-1).

189 ith ovalbumin peptide or with keyhole limpet hemocyanin (KLH).

190 e, 2,4,6-trinitrophenyl (TNP)-keyhole limpet hemocyanin (KLH).

191 48 h before immunization with keyhole limpet hemocyanin (KLH).

192 umin and a secondary antigen, keyhole limpet hemocyanin (KLH).

193 n following immunization with keyhole limpet hemocyanin (KLH).

194 icle before immunization with keyhole limpet hemocyanin (KLH).

195 nant HPV16/18 E7 antigens and keyhole limpet hemocyanin (KLH; an immunological tracer molecule) and d

196 3 after immunization with Ars-keyhole limpet hemocyanin, (KLH) and at day 6, large clusters of Ars-sp

197 C with conjugates of primary (keyhole limpet hemocyanin; KLH) and recall (Bet v 1) Ags (H4B4*KLH and

198 immunized intranasally with a keyhole limpet hemocyanin-linked peptide, corresponding to the prominen

199 However, every hemocyanin maintains downregulated key M2 cytokine genes

200 We present evidence that hemocyanin may act as a causative agent of hyperpigmenta

201 Efficacy experiments in a keyhole limpet hemocyanin model in rats demonstrated that administratio

202 tibodies were raised by using keyhole limpet hemocyanin modified in vitro by 4-hydroxynonenal (4-HNE)

203 Imaging of DNA, keyhole limpet hemocyanin, mouse monoclonal IgG, and glucose oxidase on

204 ma model, we found that compared with native hemocyanins N-deglycosylated hemocyanins elicited reduce

205 -nitrophenyl(5) conjugated to keyhole limpet hemocyanin (NP(5)- KLH) or infected with HSV-1, and the

206 -hydroxy-3-nitrophenyl acetyl-keyhole limpet hemocyanin (NP-KLH) and NP-OVA develops within ectopic l

207 phenyl acetyl (NP)-conjugated keyhole limpet hemocyanin (NP-KLH) or ovalbumin(323-337) peptide, using

208 Sequencing of the subunit of the hemocyanin of Octopus dofleini has been completed from a

209 ata, and Megathura crenulata (keyhole limpet hemocyanin), on cultures of peritoneal macrophages.

210 h a secondary Th2 response to keyhole limpet hemocyanin or A. fumagatus extract, or by intranasal rIL

211 immature DCs with the neoAgs keyhole limpet hemocyanin or human immunodeficiency virus-1 p24 gag pri

212 en-activated BALB/c Th1 clones, specific for hemocyanin or ovalbumin, did not ameliorate EAE.

213 condary Th2 lung responses to keyhole limpet hemocyanin or primary responses to Nippostrongylus larva

214 ee cell type cluster complex, keyhole limpit hemocyanin or tetanus toxoid-reactive Th cells promoted

215 Ags fluorescein-labeled (FL) keyhole limpet hemocyanin or trinitrophenylated (TNP) keyhole limpet he

216 to Pneumovax, IgG response to keyhole limpet hemocyanin, or cytokine response to LPS).

217 and B cell-deficient mice to keyhole limpet hemocyanin over 6 mo and observed diminished IL-2 produc

218 esponses by immunization with keyhole limpet hemocyanin plus IFA.

219 ared a conjugate vaccine (GD2-keyhole limpet hemocyanin plus immunological adjuvant QS-21) that consi

220 phosphocholine conjugated to keyhole limpet hemocyanin, ppc1-5 NAA B cells mounted a quick IgM Ab re

221 h the foreign helper protein, keyhole limpet hemocyanin, prior to intratumoral delivery and combining

222 ginal tumor, including (1) Id-keyhole limpet hemocyanin protein, (2) Id single-chain variable fragmen

223 In this study, hemocyanin purified from the hemolymph of Nephrops norve

224 an F(2)Pab peptide coupled to keyhole limpet hemocyanin recognized a p53(1-39) peptide phosphorylated

225 CLEC12A-mediated delivery of keyhole limpet hemocyanin resulted in enhanced proliferation and cytoki

226 , a comparison of Octopus and horseshoe crab hemocyanin reveals a similar active site, in a striking

227 led that the deglycosylation does not change hemocyanin secondary structure but alters their refoldin

228 Lastly, the conserved hemocyanin sequences allow for the inference of spider r

229 Analyses of concatenated hemocyanin sequences resolved deep nodes in the spider p

230 eptide 184- 198 conjugated to keyhole limpet hemocyanin showed significant pulmonary eosinophilia (39

231 Ag (keyhole limpet hemocyanin)-specific Th1/Th2 responses of fetal-derived

232 nation with the TCR linked to keyhole limpet hemocyanin, specific anti-TCR humoral responses were ind

233 unization with trinitrophenyl-keyhole limpet hemocyanin, specific ASC could be isolated from all immu

234 on protein, however, enhances keyhole limpet hemocyanin- specific T-cell proliferation and 2,4,6-trin

235 ce, were able to suppress the keyhole limpet hemocyanin-specific delayed-type hypersensitivity inflam

236 A-stimulated spleen cells nor keyhole limpet hemocyanin-specific proliferation of spleen cells was al

237 r upon 6-h coculture with the keyhole limpet hemocyanin-specific Th1 clone HDK-1 in the presence of A

238 ncubation with HDK-1 T cells (keyhole limpet hemocyanin-specific TH1 clone) or with 5S8 T cells (dini

239 reconstituted with a clone of keyhole limpet hemocyanin-specific Th2 cells and trinitrophenyl-specifi

240 Mollusk hemocyanins, such as Concholepas concholepas (CCH), Fiss

241 The sera raised against keyhole limpet hemocyanin-SV1 hapten, showed binding values of 50-75% a

242 similar in sequence, size, and structure to hemocyanin, the copper-containing oxygen-transport prote

243 nse to the T-dependent Ag DNP-keyhole limpet hemocyanin, the Tg mice exhibited severely impaired seco

244 ed with 2,4, 6-trinitrophenyl-keyhole limpet hemocyanin (TNP-KLH).

245 ease-inducing (TNP-conjugated keyhole limpet hemocyanin [TNP-KLH]) and disease-inhibiting (anti-CD3)

246 This represents the first molluscan hemocyanin to be completely sequenced.

247 icated decreased binding of N-deglycosylated hemocyanins to the MR and MGL receptors and TLR4 and red

248 tratumoral VVHY, VVGMCSF, and keyhole limpet hemocyanin (to produce CD4 help) generated splenic HY-sp

249 Hemocyanin transcripts were highly abundant in the hepat

250 However, the mechanisms by which hemocyanins trigger innate immune responses, leading to

251 to the coupled binuclear Cu active sites in hemocyanin, tyrosinase, and catechol oxidase, in O(2) ac

252 Coupled binuclear Cu proteins include hemocyanin, tyrosinase, and catechol oxidase.

253 O(2) ) featured in type III copper proteins (hemocyanin, tyrosinase, catechol oxidase) are vital for

254 ensitization to a neoantigen, keyhole limpet hemocyanin, using a unique model of human nasal allergic

255 elin as compared with Ghr2 or keyhole limpet hemocyanin vaccinated controls.

256 hypersensitivity response to keyhole limpet hemocyanin was diminished.

257 coupling the glycopeptide to keyhole limpet hemocyanin was examined; although both IgM and IgG antib

258 llowing immunization with DNP-keyhole limpet hemocyanin was significantly decreased for all IgG subcl

259 s, the primary Ab response to keyhole limpet hemocyanin was unaltered over a 20-day period.

260 ns, bacteriophage phiX174 and keyhole limpet hemocyanin, was also evaluated.

261 nant filarial protein Ags and keyhole limpet hemocyanin, we sensitized T cells from uninfected, nonat

262 4,6-trinitrophenyl-conjugated keyhole limpet hemocyanin were measured by ELISA, and presence of autoa

263 gh-affinity antibodies to TNP-keyhole limpet hemocyanin were severely impaired, even after adoptive t

264 alimab, antibody responses to keyhole limpet hemocyanin were transiently suppressed.

265 Hemocyanins were phagocytosed and slowly processed.

266 e response to recall antigen (keyhole limpet hemocyanin) were normal.

267 (GAD), but not the control Ag keyhole limpet hemocyanin, were eliminated in NODJg mu(null) mice.

268 inistered soluble protein Ag, keyhole limpet hemocyanin, were enhanced when mice were treated with pe

269 h or without conjugation with keyhole limpet hemocyanin, were fused with P3/NS1/1-Ag4-1 myeloma cells

270 keyhole limpet hemocyanin and C. concholepas hemocyanin, which was characterized by an increase in th

271 e, the biophysical interactions of shellfish hemocyanin with known phenoloxidase inhibitors are prese

272 nse, we investigated the effects of mollusks hemocyanins with varying structural and immunological pr