ライフサイエンスコーパス: hemocyte

1 ifferentiation into specialized blood cells (hemocytes).

2 f leukemic clam hemocytes (and not in normal hemocytes).

3 hitin in macrophage-like immune cells called hemocytes.

4 lular signal-regulated kinase (ERK) in naive hemocytes.

5 the basis of mutual repulsion in Drosophila hemocytes.

6 pact on the cytoskeleton, and stimulation of hemocytes.

7 the production of reactive oxygen species by hemocytes.

8 born neurons in crayfish can be derived from hemocytes.

9 une responses in immune cells, in particular hemocytes.

10 ance between prohemocytes and differentiated hemocytes.

11 tinct patterns, but were mainly expressed in hemocytes.

12 2 and Pvf3 to the Pvr trophic maintenance of hemocytes.

13 onses in other insects, and immune-competent hemocytes.

14 a CvGal1 glycoprotein ligand associated with hemocytes.

15 to coordinate trans-epithelial migration of hemocytes.

16 mbryonically derived- and larval lymph gland hemocytes.

17 induces plasmatocyte maturation in adjacent hemocytes.

18 with prodigious production of differentiated hemocytes.

19 tions as an opsonin favoring phagocytosis by hemocytes.

20 in blood cell progenitors and differentiated hemocytes.

21 calization in the cytoplasm of leukemic clam hemocytes.

22 3, and results in apoptosis of leukemic clam hemocytes.

23 s expressing tetraspanin mediate adhesion of hemocytes.

24 ual hemocytes or encapsulated by interacting hemocytes.

25 s accompanied by abnormal differentiation of hemocytes.

26 n mechanism to passively gain entry into the hemocytes.

27 ranscript abundance usually being highest in hemocytes.

28 vely charged nature makes it unattractive to hemocytes.

29 rosine phosphatase activity than noninfected hemocytes.

30 o melanizations that are not encapsulated by hemocytes.

31 the host fat body and those that target host hemocytes.

32 process that discriminates between glia and hemocytes.

33 the HPT increased the number of circulating hemocytes.

34 regulates the proliferation and adhesion of hemocytes.

35 , which comprise the vast majority of mature hemocytes.

36 per controlling the periodic movement of the hemocytes.

37 and the plasma membrane of a subset of snail hemocytes (60%), it was not detected in cell-free plasma

38 Specifically, for hemocytes, a genotype-by-mating status interaction media

39 naling and the Jak/Stat pathway ligand Upd3, hemocytes act as sentinels of bacterial infection, induc

40 ia the DOP1 receptor may contribute to early hemocyte activation.

41 As demonstrated with a hemocyte adhesion assay and a surface plasmon resonance

42 MdBV-infected hemocytes also exhibited higher levels of tyrosine phosp

43 MdBV infects primarily host hemocytes and also infects a hemocyte-derived cell line

44 ons, show a progressive apoptotic decline in hemocytes and an incomplete resident hemocyte pattern, w

45 P transcripts are expressed primarily in the hemocytes and are increased at 24 h after pathogenic bac

46 s characterized by the absence of phagocytic hemocytes and atypical expression of immunity-related ge

47 glycoproteins, hemocyte extracts, and intact hemocytes and by surface plasmon resonance analysis.

48 lts in a leukemia-like over-proliferation of hemocytes and copious differentiation of lamellocytes du

49 Hemocytes and hemocyte microaggregations were quantified

50 gon and w1118 flies possess more circulating hemocytes and higher levels of phenoloxidase activity th

51 in the larval lymph gland and in circulating hemocytes and interacts with Asrij.

52 that Drosophila Vps8 is highly expressed in hemocytes and nephrocytes, and localizes to early endoso

53 , and weight) and immune response (number of hemocytes and phenoloxidase activity) of the nonbiting m

54 asdhA mutant caused a transient depletion of hemocytes and reduced mortality.

55 xicity is dependent on a direct contact with hemocytes and requires an ancestral gene encoding a prot

56 ect first tick midgut cells and subsequently hemocytes and salivary glands from where transmission oc

57 are expressed constitutively in fat body and hemocytes and secreted into plasma, where they are activ

58 ant disrupted in Mcl1 is rapidly attacked by hemocytes and shows a corresponding reduction of virulen

59 PLL exhibited an ability to bind to insect hemocytes and the cuticular surface of a nematode, H. ba

60 developmental defects, overproliferation of hemocytes and the formation of melanotic tumors or nodul

61 ted to the loss of lwr function primarily in hemocytes and the lymph glands, a hematopoietic organ in

62 related sugar, lacNAc, and strongly binds to hemocytes and the tegument of S. mansoni sporocysts in a

63 complexed in the cytoplasm of leukemic clam hemocytes (and not in normal hemocytes).

64 rtical remodeling of Drosophila blood cells (hemocytes) and mouse macrophages.

65 at were similarly expressed in immune cells (hemocytes) and ovarian somatic cells (stretched cells) d

66 ent transcription factor that controls glia, hemocyte, and tendon cell differentiation in Drosophila.

67 evels were specifically elevated in diseased hemocytes, and high expression was correlated with disea

68 t BgGRN induces proliferation of B. glabrata hemocytes, and specifically drives the production of an

69 First, Repo expression is repressed in the hemocyte anlagen by mesoderm-specific factors.

70 Hemocytes appear involved in debris removal and seem to

71 the mechanism(s) for parasite entry into the hemocyte are unknown.

72 We investigated whether insect hemocytes are capable of de novo DA production.

73 lyses demonstrate that the majority of adult hemocytes are phagocytic macrophages (plasmatocytes) fro

74 During late larval stages three types of hemocytes are produced, plasmatocytes, crystal cells, an

75 their different origins, Drosophila glia and hemocytes are related cell populations that provide an i

76 sensory neurons, epidermal cells rather than hemocytes are the primary phagocytes in clearing degener

77 These studies identify hemocytes as a source of adult-born neurons in crayfish

78 d respond to parasite infection, implicating hemocytes as critical modulators of the late-phase immun

79 ed on these data, we introduce leukemic clam hemocytes as novel and easily accessible, in vivo and in

80 significantly increased in gills at 4h, and hemocytes at 0 h and 4 h, while HdHIF-1beta expression s

81 gulated in gills at 4h, 24h and 96 h, and in hemocytes at 24h and 96 h, while HdHIF-1beta remained re

82 as lower than the blank and control group in hemocytes at 4 h, 12 h and 24 h (p < 0.05).

83 ntify an extensive reservoir of blood cells (hemocytes) at the respiratory epithelia (tracheal air sa

84 were altered and the density of circulating hemocytes (blood cell analog) was significantly reduced,

85 Drosophila hemocytes (blood cells) have emerged as a powerful syste

86 in a sugar-inhibitable fashion suggest that hemocyte-bound galectin may be serving as a pattern reco

87 Interestingly, CanA1 RNAi in hemocytes but not the fat body was sufficient to block i

88 e not required for the directed migration of hemocytes, but act locally in epithelial cells to coordi

89 isoforms were expressed at similar levels in hemocytes, but in fat body isoform B mRNA was present at

90 and forth between epithelial disc cells and hemocytes by extracellular ROSs and TNF/Eiger drives ove

91 novel MT isoform (CvMT-IV) was isolated from hemocytes by subtractive hybridization techniques follow

92 rix components, the fly blood cells known as hemocytes can be relocated to tissue surfaces where they

93 Host hemocytes can recognize and ingest its conidia, but this

94 in multiple migratory cell types, including hemocytes, caudal visceral mesoderm (CVM), the visceral

95 Hemocyte collision and subsequent repulsion involves a s

96 vations were linked to changes in the larval hemocyte composition, showing changes in cell types impo

97 mph gland hypertrophy, increased circulating hemocyte concentration, and abundant production of lamel

98 Surface proteins of hemocytes control the abrupt transition of hemocytes fro

99 Hemocytes coordinate a robust and specific immunological

100 in crayfish is tightly correlated with total hemocyte counts (THCs) and can be manipulated by raising

101 ypoxia exposure, both Tbeta-4 expression and hemocyte counts declined.

102 1-alpha and down-regulated Tbeta-4, although hemocyte counts were unaffected.

103 ression of HIF1-alpha and Tbeta-4 along with hemocyte counts, biomarkers of hypoxic stress and immune

104 e internalizing amnioserosa tissue by mutant hemocytes coupled with impaired midline zippering of mut

105 EBP levels within peripheral differentiating hemocytes, culminating in their premature release into c

106 heral neurons and we demonstrate that larval hemocytes depend on the PNS as an attractive and trophic

107 genotype-by-genotype interaction determined hemocyte depletion post mating.

108 ing Drosophila embryogenesis depends on both hemocyte-deposited extracellular matrix and neural activ

109 primarily host hemocytes and also infects a hemocyte-derived cell line from P. includens called CiE1

110 arallel glycomic study carried out on oyster hemocytes determined the structures of oligosaccharides

111 ur study provides detailed insights into the hemocyte development and cellular immune responses at si

112 know nothing about the endogenous control of hemocyte development in any gastropod model.

113 for spatial and temporal events that govern hemocyte development.

114 regulate the cytoskeleton during a subset of hemocyte developmental migrations.

115 However, circulating hemocytes did aggregate over the needle-puncture wound t

116 Correlatively, no hemocytes differentiate.

117 the choice between progenitor quiescence and hemocyte differentiation [the posterior signaling center

118 kdown experiments indicate that LL3 mediates hemocyte differentiation during immune priming.

119 lood cell precursor maintenance and prevents hemocyte differentiation during larval hematopoiesis.

120 One regulatory network known to control hemocyte differentiation is the Janus kinase (JAK)/Signa

121 lvement of this pathway in the regulation of hemocyte differentiation through its action in the hemat

122 l-autonomous and non-autonomous functions in hemocyte differentiation.

123 ogenitor population and preventing premature hemocyte differentiation.

124 matopoietic precursor state while preventing hemocyte differentiation.

125 cells in the lymph gland results in abnormal hemocyte differentiation.

126 Consequently, hemocytes disrupted for autophagy were impaired in their

127 leted hemocyte population and a breakdown in hemocyte distribution.

128 use the Drosophila embryo to investigate how hemocytes (Drosophila macrophages), are able to prioriti

129 we identify the developmental trajectory of hemocytes during normal development as well as the emerg

130 require secretion by migrating macrophages (hemocytes) during their developmental dispersal, which i

131 required in muscles, but not in fat body or hemocytes, during larval development for an efficient en

132 Layers of hemocytes encapsulated larvae immediately after infectio

133 oncentration there was lowest at night, when hemocytes entered the crypts.

134 Surprisingly, we find no sign of adult hemocyte expansion.

135 Hemocytes express a larger range of glycans, including c

136 ith intact and deglycosylated glycoproteins, hemocyte extracts, and intact hemocytes and by surface p

137 fob hemocytes (fly macrophages) engulf bacteria but fail to

138 ue, but confirm the essential role of Pvr in hemocytes for embryonic survival.

139 cs, neurons, fat body, tracheae, muscles and hemocytes, for up to 8 h.

140 dy (three genes) and those expressed in host hemocytes (four genes).

141 f hemocytes control the abrupt transition of hemocytes from resting, nonadherent cells to activated,

142 do not appear to be able to take shelter in hemocytes from the action of the Toll pathway, the effec

143 actor, glia originate from the ectoderm, and hemocytes from the mesoderm.

144 l being instead sustained via integration of hemocytes generated by the innate immune system.

145 Proteomic analysis of the hemocyte glycoproteins identified beta-integrin and domi

146 c organ comprised of prohemocytes and mature hemocytes, has been a valuable model for understanding m

147 We show that leukemic clam hemocytes have an intact p53 pathway, and that maintenan

148 Three types of mature hemocytes have been characterized in the lymph gland: pl

149 t molecular underpinnings of the lymph gland hemocytes have been less investigated.

150 Immune cells known as hemocytes, have been intricately associated with phagocy

151 ogether, our data show that Collier controls hemocyte homeostasis via coordinate regulation of PSC ce

152 ed that L. pneumophila resided within insect hemocytes in a vacuole that ultrastructurally resembled

153 n and trophic maintenance of macrophage-like hemocytes in Drosophila melanogaster embryos.

154 ensively analyze heterogeneity of developing hemocytes in the lymph gland, and discover previously un

155 lly differentiate in the nervous system, and hemocytes in the procephalic mesoderm.

156 Tracking actin retrograde flow within hemocytes in vivo reveals synchronous reorganization of

157 ion regulates the production of blood cells (hemocytes) in Drosophila larvae.

158 resent at enormously high levels in diseased hemocytes, indicative of extensive reverse transcription

159 tantly, oyster ETs were evidenced in vivo in hemocyte-infiltrated interstitial tissues surrounding wo

160 This model includes hemocyte integration and intrinsic cell proliferation to

161 e niche cell pool is not only replenished by hemocyte integration but also by limited numbers of symm

162 e migration and highlight novel Pvf roles in hemocyte invasive migration.

163 challenge, transcriptomes of H. diversicolor hemocytes involved in immunity were profiled.

164 scapularis ISE6 tick cells, a model for tick hemocytes involved in pathogen infection.

165 LL3 expression in the midgut and hemocytes is activated by ookinete midgut invasion and i

166 This overproduction of hemocytes is attributed to the loss of lwr function prim

167 Drosophila lymph gland, the source of adult hemocytes, is established by mid-embryogenesis.

168 electron transport chain complex assays, and hemocyte isolation from Drosophila larvae.

169 and, despite successful phagocytosis by host hemocytes, killed caterpillars both at 37 degrees C and

170 r of 5-ethynyl-2'-deoxyuridine (EdU)-labeled hemocytes, labeled cells populate the neurogenic niche c

171 Hemocytes lacking Stat fail to differentiate into plasma

172 bee survival, flower visitation, heart rate, hemocyte levels, and expression of genes related to lipi

173 Here, we use insect plasmatocytes and hemocyte-like Drosophila S2 cells to characterize mechan

174 embers and conducted functional studies with hemocyte-like Drosophila S2 cells.

175 Hemocytes limit the capacity of mosquitoes to transmit h

176 We identify and validate two main hemocyte lineages and find evidence of proliferating gra

177 intenance and some cell fate choices between hemocyte lineages.

178 The removal of panulirin from the lobster hemocyte lysate leads to an increase in phenoloxidase re

179 ing concentrations of panulirin to a lobster hemocyte lysate, previously depleted of trypsin-inhibito

180 asmaniensis use distinct mechanisms to cause hemocyte lysis.

181 the lack of Repo triggers the expression of hemocyte markers in glia.

182 progenitors (IPs) expressing prohemocyte and hemocyte markers.

183 DA synthesized and released from hemocytes may act in an autocrine mechanism to stimulate

184 bdivided into melanotic nodules engaging the hemocyte-mediated encapsulation and into melanizations t

185 elanotic masses were generally linked to the hemocyte-mediated immune response.

186 Hemocytes and hemocyte microaggregations were quantified for female ce

187 We show here that, just before dusk, hemocytes migrate from the vasculature into the symbioti

188 ntal migrations in which posteriorly located hemocytes migrate toward the head.

189 In the absence of hemocytes migrating adjacent to the developing VNC, the

190 Our findings redefine Pvf roles in hemocyte migration and highlight novel Pvf roles in hemo

191 Trpml is needed for both hemocyte migration and phagocytic processing at distinct

192 t subcellular localizations: Trpml regulates hemocyte migration by controlling actomyosin contractili

193 Finally, Ena rescues hemocyte migration defects caused by activated Dia.

194 Indeed, hemocyte migration is essential to deliver a subset of E

195 Failure of hemocyte migration, loss of collagen IV, or abrogation o

196 ligands, Pvf2 and Pvf3 in the regulation of hemocyte migration, proliferation, and size.

197 Studies with staining reagents and hemocyte monolayers showed that MCL1 functions as an ant

198 utility of G(PA)C is exemplified by tracking hemocyte movements using a versatile transgenic Drosophi

199 The primary features of the oyster whole hemocyte N-glycome were also found in dominin, the major

200 fic Abs localized to 3-day p.p. fat-body and hemocyte nuclei, suggesting a role for vankyrin proteins

201 of NAC, a delay in the recovery rate of the hemocyte number was observed.

202 in the rapid restoration of the circulating hemocyte number.

203 Here we profile the transcriptomes of 8506 hemocytes of Anopheles gambiae and Aedes aegypti mosquit

204 9, 12, 13, 25, 27, 32 and 34 in fat body and hemocytes of larvae injected with bacteria.

205 that integrins perform diverse functions in hemocytes of silkworm.

206 heet antimicrobial peptide isolated from the hemocytes of Tachypleus tridentatus.

207 opoietic system is founded by differentiated hemocytes of the embryo, which colonize segmentally repe

208 We found here that the hemocytes of the oyster Crassostrea gigas release antimi

209 d PEN2, PEN3, and PEN4, are expressed in the hemocytes of the Pacific white shrimp, Litopenaeus vanna

210 an embryonic cell line (Bge) and circulating hemocytes of the snail Biomphalaria glabrata, intermedia

211 nhibitor, named panulirin, isolated from the hemocytes of the spiny lobster Panulirus argus with regu

212 The immune cells (hemocytes) of a snail are sentinels that act as a crucia

213 runcated variant, 620-fold above normal clam hemocytes) of human mortalin, an Hsp70 family protein.

214 but many must be phagocytosed by individual hemocytes or encapsulated by interacting hemocytes.

215 f the highly conserved ortholog, cut, led to hemocyte overgrowth and tumor formation in Drosophila me

216 owed that virulent strains were cytotoxic to hemocytes, oyster immune cells.

217 In untreated leukemic clam hemocytes, p53 is complexed throughout the cytoplasm wit

218 Drosophila hemocytes patrol the body cavity and act as macrophages

219 line in hemocytes and an incomplete resident hemocyte pattern, whereas supernumerary peripheral neuro

220 he symbionts catabolize chitin released from hemocytes (phagocytic immune cells) that traffic into th

221 Hemocytes phagocytosed bacteria after injection, and ant

222 his study, we found that DA modulates insect hemocyte phagocytosis using hemocytes prepared from the

223 1 receptor with antagonist SCH23390 impaired hemocyte phagocytosis.

224 s and the phagocytosis receptor Eater on the hemocytes physically interact and are necessary and suff

225 Instead, hemocytes play a role in relaying an innate immune respo

226 pvr mutants have a depleted hemocyte population and a breakdown in hemocyte distribu

227 teristics that traditionally define mosquito hemocyte populations.

228 f hemocytes, whereas the other was active in hemocyte precursors and plasmatocytes only.

229 During larval stages, a pool of pluripotent hemocyte precursors differentiate into hemocytes that ar

230 the lymph gland (LG), within which stem-like hemocyte precursors or prohemocytes differentiate to mul

231 modulates insect hemocyte phagocytosis using hemocytes prepared from the rice stem borer (RSB), Chilo

232 s, a niche regulates prohemocytes to control hemocyte production.

233 Hemocyte proliferation and differentiation are influence

234 nstrate that U-shaped acts to control larval hemocyte proliferation and suppress lamellocyte differen

235 infection with S. mansoni by first inducing hemocyte proliferation with BgGRN.

236 At least one isoform of serpin-1 can inhibit hemocyte proteinase 1, another M. sexta blood proteinase

237 In Drosophila, glia and hemocytes provide a scavenger activity within and outsid

238 In this study, we show that oyster hemocytes recognize P. marinus via a novel galectin (C.

239 expressed at high levels by tumor-associated hemocytes recruited from the circulation.

240 progenitor cells in the tissue and to reduce hemocyte release.

241 The hemocyte-released DNA was found to surround and entangle

242 Here, we show that Drosophila hemocytes require a precisely orchestrated CIL response

243 heral nervous system (PNS), and blood cells (hemocytes) require the PNS for their survival and recrui

244 These hemocyte responses depend on PNS activity, as shown by a

245 ression of mutant Idh in larval blood cells (hemocytes) resulted in higher numbers of circulating blo

246 ound that in the absence of SdhA, the LCV in hemocytes showed signs of instability and leakage.

247 The conserved hemocyte-specific endosomal protein Asrij is essential f

248 xpression in turn inhibits the expression of hemocyte-specific genes in the nervous system.

249 m is sufficient to repress the expression of hemocyte-specific genes.

250 ween the large extracellular loop domain and hemocyte-specific integrin is interrupted not only by a

251 acellular loop of tetraspanin D76 binds to a hemocyte-specific integrin of Manduca sexta.

252 autophagy was required for integrin-mediated hemocyte spreading and Rho1-induced cell protrusions.

253 RNAi reduction of Se-sEH interfered with hemocyte-spreading behavior, nodule formation, and AMP e

254 wever, the lack of genetic tools has limited hemocyte study despite their importance in mosquito anti

255 fically drives the production of an adherent hemocyte subset that participates centrally in the anti-

256 ChIP) localizes NURF to Ken-binding sites in hemocytes, suggesting that Ken recruits NURF to repress

257 The genotype-by-genotype effect on hemocytes supports a role of sexual conflict in post-mat

258 om the blood group A oligosaccharides on the hemocyte surface may function as potentially effective l

259 oss-linking to beta-integrin, located on the hemocyte surface, leading to cell activation, phagocytos

260 lood group moieties on oyster dominin and on hemocyte surfaces can account in part for their affinity

261 s interaction of integrin and tetraspanin on hemocyte surfaces.

262 , ligand-independent mechanism that promotes hemocyte survival during both normal hematopoietic devel

263 d enhance the phenoloxidase (PO) activity of hemocyte suspensions in the presence of LPS or beta-1,3-

264 otent hemocyte precursors differentiate into hemocytes that are released into circulation upon metamo

265 bundance of granulocytes, a subpopulation of hemocytes that circulates in the insect's hemocoel, and

266 hila immune cells within (glia) and outside (hemocytes) the nervous system require the same transcrip

267 with extracellular DNA networks released by hemocytes, the circulating immune cells of invertebrates

268 pling of cell locomotion and phagocytosis in hemocytes, the Drosophila macrophage-like immune cells.

269 ncrease in proliferation of undifferentiated hemocytes throughout development and is accompanied by a

270 Importantly, we show that these resident hemocytes tightly colocalize with peripheral neurons and

271 decrease in EsMIF concentration permits the hemocytes to be drawn into the crypts, delivering chitin

272 silencing abrogates the ability of mosquito hemocytes to differentiate and respond to parasite infec

273 Attachment and spreading of hemocytes to foreign surfaces induced localization of Cv

274 Here we show that exposing hemocytes to lipopolysaccharide (LPS) led to induction o

275 a DA-dependent signaling system operates in hemocytes to mediate phagocytotic functions.

276 Exposure of hemocytes to Perkinsus spp. trophozoites enhanced this p

277 h-promoted immune responses and functions in hemocytes to promote a tissue-to-tissue signaling cascad

278 n of the proneural gene scute (sc) misdirect hemocytes to these ectopic locations.

279 rvae with fluorescently labeled blood cells (hemocytes) to investigate the circulatory dynamics of la

280 po) adults can be reversed when they receive hemocytes transplanted from wild-type donor flies prior

281 Inside oyster hemocytes, trophozoites resist oxidative killing, prolif

282 h gland, and discover previously undescribed hemocyte types including adipohemocytes, stem-like prohe

283 Yet, throughout larval development, both hemocyte types increase in numbers.

284 Drosophila immune cells, the hemocytes, undergo four stereotypical developmental migr

285 The expression of TNF by hemocytes was both necessary and sufficient to trigger T

286 In mosquitoes, differentiation of hemocytes was necessary and sufficient to confer innate

287 a-4 expression increased, while no effect on hemocytes was observed.

288 Most MdBV genes expressed in hemocytes were persistently expressed in CiE1 cells, inc

289 is expressed in circulating and lymph gland hemocytes, where it plays a critical role in controlling

290 EsMIF inhibited migration of isolated hemocytes, whereas exported bacterial products, includin

291 One enhancer was active in all classes of hemocytes, whereas the other was active in hemocyte prec

292 formation and activates the proliferation of hemocytes which invade the lesion site.

293 llular ROSs activate Drosophila macrophages (hemocytes), which in turn trigger JNK activity in epithe

294 mors is due to a large number of circulating hemocytes, which is approximately 10 times higher than t

295 VEGF/PDGF ligands from the tubules attract hemocytes, which secrete components of the basement memb

296 study, we examined the N-glycans of both the hemocytes, which via CvGal1 are the target of the parasi

297 In leukemic clam hemocytes, wild-type p53 and mortalin proteins co-locali

298 e partially inhibited by pretreatment of the hemocytes with anti-CvGal Abs.

299 In addition, treatment of leukemic clam hemocytes with MKT-077, a cationic inhibitor of mortalin

300 Our data reveal the functional diversity of hemocytes, with different subtypes of granulocytes expre