戻る
「早戻しボタン」を押すと検索画面に戻ります。 [閉じる]

コーパス検索結果 (１語後でソート)

通し番号をクリックするとPubMedの該当ページを表示します
1 ease TMPRSS6 that cleaves the BMP coreceptor hemojuvelin.
2 d conditional knockout mice that lack muscle hemojuvelin.
3 e membrane involving BMP, its receptors, and hemojuvelin.
4 rified by its binding to an uncleaved mutant hemojuvelin.
5 errin receptor 2, ferroportin, hepcidin, and hemojuvelin.
6 petition between soluble and cell-associated hemojuvelin.
7 owth differentiation factor-11/8], and RGMC [hemojuvelin]).
8       Repulsive guidance molecule c (RGMc or hemojuvelin), a glycosylphosphatidylinositol-linked glyc
9                                              Hemojuvelin, a glycophosphatidyl inositol-linked membran
10                                              Hemojuvelin, a protein critical for maintaining appropri
11  support a key role for BMP6 as a ligand for hemojuvelin and an endogenous regulator of hepcidin expr
12 e hepcidin expression, a process enhanced by hemojuvelin and blunted in Hfe2-/- hepatocytes.
13  we report expression of soluble versions of hemojuvelin and neogenin for biochemical characterizatio
14 est that MT2 suppresses hepcidin by cleaving hemojuvelin and other components of the bone morphogenet
15 hepatocytes in vitro; and measured hepcidin, hemojuvelin, and ferroportin-1 gene expression.
16 s of hepcidin mRNA, it did not interact with hemojuvelin, and interference with its signaling pathway
17 y of a new gene involved in iron metabolism, hemojuvelin, and new data on the role of HFE mutations i
18 endent pathway requires the presence of Hfe, hemojuvelin, and probably transferrin receptor 2 (tfr-2)
19                   We show that a robust BMP, hemojuvelin, and SMAD1 response by murine Hamp1 is depen
20 y known iron metabolic proteins such as HFE, hemojuvelin, and transferrin receptor 2 are expanding th
21     Neogenin binds to cleaved and noncleaved hemojuvelin, as verified by its binding to an uncleaved
22                             We localized the hemojuvelin binding site on neogenin to the membrane-pro
23 hanism of this process is not clear, several hemojuvelin-binding proteins, including the cell surface
24 ulate hepcidin mRNA concentrations through a hemojuvelin/BMP2/4-dependent pathway.
25 coordination of multiple proteins, including hemojuvelin, bone morphogenetic protein 6 (BMP6), heredi
26                  The protein product of HJV, hemojuvelin, contains a C-terminal glycosylphosphatidyli
27  which HFE2 mutations cause hemochromatosis: hemojuvelin dysfunction decreases BMP signaling, thereby
28 alytic cleavage, and as in vivo, recombinant hemojuvelin exists as a mixture of cleaved and uncleaved
29 ding HFE, transferrin receptor 2 (TfR2), and hemojuvelin, function at least in part, by modulating th
30 s caused by mutations in the recently cloned hemojuvelin gene (HJV; also called HFE2), whereas Type 2
31 rotein (HFE), transferrin-receptor 2 (TfR2), hemojuvelin, hepcidin, or ferroportin genes.
32 ee hemochromatosis-associated proteins: HJV (hemojuvelin), HFE (hemochromatosis protein), and TfR2 (t
33  BMP2/4 and hemochromatosis-related proteins hemojuvelin, HFE and transferrin receptor 2, also regula
34  iron regulatory hormone hepcidin (HAMP) and hemojuvelin (HFE2).
35               Mutations in the gene encoding hemojuvelin (HFE2, also known as HJV) cause severe iron
36                                         Both hemojuvelin (HJV) and bone morphogenic protein-6 (BMP6)
37                    Cells co-transfected with hemojuvelin (HJV) and matriptase-2 (MT-2) were used as a
38                                              Hemojuvelin (HJV) and matriptase-2 (MT2) are co-expresse
39  (BMPs) through a receptor complex requiring hemojuvelin (HJV) as a co-receptor.
40 ic proteins (BMPs), apparently by binding to hemojuvelin (Hjv) as a coreceptor and signaling through
41                                 Mutations in hemojuvelin (HJV) cause severe, early-onset juvenile hem
42  the HFE, transferrin receptor-2 (TfR2), and hemojuvelin (HJV) genes.
43 netic protein 6 (BMP6) or the BMP coreceptor hemojuvelin (HJV) in mice leads to a similar phenotype w
44                                              Hemojuvelin (HJV) is a coreceptor for bone morphogenetic
45                                              Hemojuvelin (HJV) is a glycosylphosphatidylinositol-link
46                                              Hemojuvelin (HJV) is an important regulator of iron meta
47  severe form, usually caused by mutations in hemojuvelin (HJV) or hepcidin (HAMP).
48                                              Hemojuvelin (HJV) regulates iron homeostasis by direct i
49                                              Hemojuvelin (HJV) was recently identified as a critical
50 ontrast, mice deficient for both Tmprss6 and hemojuvelin (Hjv), a BMP coreceptor that augments hepcid
51                            It interacts with hemojuvelin (HJV), a BMP coreceptor that plays a pivotal
52  to regulate hepcidin production by cleaving Hemojuvelin (Hjv), a key modulator of hepcidin expressio
53                                              Hemojuvelin (HJV), encoded by the gene HFE2, is a critic
54                                              Hemojuvelin (HJV), HFE, and transferrin receptor-2 (TfR2
55 rrence of compound heterozygous mutations in hemojuvelin (HJV), including a termination codon, in a p
56                         Its encoded protein, hemojuvelin (HJV), is a co-receptor for the bone morphog
57                            RGMc, also called hemojuvelin (HJV), is essential for iron homeostasis.
58 in (HAMP), homeostatic iron regulator (HFE), hemojuvelin (HJV), nuclear factor erythroid 2-related fa
59 tions in HFE, transferrin receptor 2 (Tfr2), hemojuvelin (HJV), or bone morphogenetic protein 6 (BMP6
60 sis type 2 (HFE2), which encodes the protein hemojuvelin (HJV), result in the absence of hepcidin and
61                    Similarly, RPE cells from hemojuvelin (Hjv)-knockout mice, another model of hemoch
62                            It interacts with hemojuvelin (HJV).
63  is strongly modulated by the BMP coreceptor hemojuvelin (HJV).
64 main is greatly attenuated in the absence of hemojuvelin (Hjv).
65 y iron loading in hh are hepcidin (HAMP) and hemojuvelin (HJV).
66                    We also show that soluble hemojuvelin (HJV.Fc) selectively inhibits BMP induction
67      Here we show that compared with soluble hemojuvelin (HJV.Fc), the homologous DRAGON.Fc is a more
68                                              Hemojuvelin (HJV; also called repulsive guidance molecul
69        However, neither the specific role of hemojuvelin in maintaining iron homeostasis nor its rela
70 idin expression were not affected by loss of hemojuvelin in skeletal muscle regardless of dietary iro
71                To explore possible roles for hemojuvelin in skeletal muscle, we analyzed conditional
72 ron regulatory hormone, by cleaving membrane hemojuvelin into an inactive form.
73                         Here, we report that hemojuvelin is a BMP coreceptor and that hemojuvelin mut
74                                              Hemojuvelin is a bone morphogenetic protein (BMP) co-rec
75                We have previously shown that hemojuvelin is a co-receptor for bone morphogenetic prot
76                  We have recently shown that hemojuvelin is a coreceptor for bone morphogenetic prote
77                                              Hemojuvelin is a member of the repulsive guidance molecu
78                                              Hemojuvelin is a recently identified iron-regulatory pro
79 ave any known function outside of the liver, hemojuvelin is expressed at very high levels in cardiac
80 de that, in spite of its expression pattern, hemojuvelin is primarily important in the liver.
81                                      We used hemojuvelin-knockout (Hjv(-/-)) mice to examine whether
82  inhibitors pacritinib and momelotinib, anti-hemojuvelin monoclonal antibody DISC-0974C) are currentl
83  we used hemojuvelin-specific siRNAs to vary hemojuvelin mRNA concentration and showed that cellular
84 hat hemojuvelin is a BMP coreceptor and that hemojuvelin mutants associated with hemochromatosis have
85 mochromatosis is associated with hepcidin or hemojuvelin mutations, and these patients have low or ab
86                                              Hemojuvelin normally undergoes an autocatalytic cleavage
87  rarer instances, transferrin-receptor 2 and hemojuvelin, or make its receptor ferroportin, resistant
88  mRNA concentration and showed that cellular hemojuvelin positively regulated hepcidin mRNA expressio
89 te with low hepcidin levels, suggesting that hemojuvelin positively regulates hepcidin expression.
90 at BMP-2 and neogenin bind simultaneously to hemojuvelin raises the possibility that neogenin is part
91  We propose that soluble and cell-associated hemojuvelin reciprocally regulate hepcidin expression in
92 lthough our previous studies have shown that hemojuvelin regulates hepcidin expression and iron metab
93 s engineered to express hemojuvelin, soluble hemojuvelin release was progressively inhibited by incre
94                    Inactivating mutations in hemojuvelin/repulsive guidance molecule c (HJV/RGMc) cau
95  guidance molecules RGMa, DRAGON (RGMb), and hemojuvelin (RGMc) as coreceptors for BMP signaling.
96 ption-level changes of the murine homolog of Hemojuvelin (Rgmc).
97      We also showed that recombinant soluble hemojuvelin (rs-hemojuvelin) suppressed hepcidin mRNA ex
98               In cells engineered to express hemojuvelin, soluble hemojuvelin release was progressive
99                        In this study we used hemojuvelin-specific siRNAs to vary hemojuvelin mRNA con
100  present study, we show in mice that loss of hemojuvelin specifically in the liver leads to decreased
101 wed that recombinant soluble hemojuvelin (rs-hemojuvelin) suppressed hepcidin mRNA expression in prim
102  EC BMP6 has paracrine actions on hepatocyte hemojuvelin to regulate hepcidin transcription and maint
103 ne (LOC148738) encoding a protein designated hemojuvelin was cloned.
104                                      Soluble hemojuvelin was found in human sera at concentrations si
105                                              Hemojuvelin was localized on the hepatocyte sinusoidal m
106          Localization of the BMP co-receptor hemojuvelin was visualized by immunofluorescence microsc
107 ) family members RGMa, RGMb/Dragon, and RGMc/hemojuvelin were found recently to act as bone morphogen
108 evels of soluble and membrane-bound forms of hemojuvelin, which in turn would influence the amount of

 
Page Top