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1 e inhibitor (EGFR TKI) resistance induced by heregulin.
2 3/ErbB2 chimeras confirm this dual effect of heregulin.
3 and the mechanism of oligomer disruption by heregulin.
4 rs are destabilized by binding of the ligand heregulin.
5 with HER2/NEU or its transactivating ligand HEREGULIN.
6 readily detected 2 min after the addition of heregulin.
7 er cell lines were screened for responses to heregulin.
8 ErbB2-overexpressing cells in the absence of heregulin.
9 rosine kinase in the presence and absence of heregulin.
10 spholipase C (PLC)-gamma1 with HER2 than did heregulin.
11 fect of cucurbitacin I on Rac1 activation by heregulin.
12 failed to affect the activation of P-Rex1 by heregulin.
13 ding the heterodimer ligands EGF/TGFalpha or heregulin.
14 ibited the lamellipodia formation induced by heregulin.
15 ed secretion of TGF-alpha, amphiregulin, and heregulin.
16 prominent among these are the Neuregulins or Heregulins.
17 le defined medium containing an IGF1 analog, heregulin-1beta (a ligand for ERBB2/ERBB3), fibroblast g
20 cer cells and, in particular, in response to heregulin, a growth factor that activates the Neu/ErbB2
21 In the present study, we examined whether heregulin, a HER3 ligand that is also overexpressed in a
26 n-binding growth factors, as well as that to heregulin alpha, heregulin beta, and hepatocyte growth f
27 , immediately following a mechanical injury, heregulin-alpha activates erbB2 in cells at the edge of
29 at in differentiated human airway epithelia, heregulin-alpha is present exclusively in the apical mem
31 cells, LMO4 transcripts were upregulated by heregulin, an activator of ErbB receptors that are known
32 strongly induced by the transforming ligand heregulin and complexes incorporated a number of additio
34 ption in breast carcinoma cells treated with heregulin and this effect was inhibited by MTA1 knockdow
37 ely produce both a ligand, the growth factor heregulin, and its receptors--erbB2, erbB3 and erbB4.
38 t signal was specific to ErbB3 activation by heregulin, and was not observed in response to epidermal
39 own of Ack1 or Src showed that Ack1 mediates heregulin- and Gas6-induced AR Tyr-267 phosphorylation,
42 ntial display of mRNA that the growth factor heregulin beta 1 (HRG), a combinatorial ligand for human
43 4ICD and STAT5A colocalize within nuclei of heregulin beta 1 (HRG)-stimulated cells and both protein
47 e to the peptide growth factors (IGF-1, EGF, heregulin-beta, and bFGF), and partially blocked the res
48 of increasing concentrations of IGF-1, EGF, heregulin-beta, bFGF, or estrogen under un-induced and i
53 aused by fibroblast growth factor 1 (FGF-1), heregulin beta1 (HRGbeta1), and epidermal growth factor
54 an be induced by the highly malignant factor heregulin beta1 (HRGbeta1), which induces HSP expression
56 GF) receptor family that can be activated by heregulin beta1 and heparin binding (HB)-EGF, is express
61 ctivity during colon cancer cell invasion by heregulin-beta1 (HRG) and prostaglandin E2 (PGE2), we ha
64 pression in combination with the HER4 ligand heregulin-beta1 (HRG) resulted in apoptosis of BT20 cell
65 hiolated form of the HER3-binding peptide of heregulin-beta1 (HRG) with or without a 12- or 24 mer po
68 ), insulin-like growth factor-I (IGF-I), and heregulin-beta1 (HRG-beta1), can modulate the expression
73 on by growth factors, MMP-9 was activated by heregulin-beta1 as shown by zymography in both SKBr3 and
74 so associated with ErbB3 in LNCaP cells, and heregulin-beta1 enhanced this interaction and further st
75 els were still markedly decreased by EGF and heregulin-beta1 in LNCaP cells adapted to growth in andr
76 study was undertaken to explore the role of heregulin-beta1 in regulating uPA and uPAR in breast can
81 hat activation of these kinases with EGF and heregulin-beta1 rapidly (within 8 hours) decreased expre
84 reatment of these cells with the EGFR ligand heregulin-beta1 signals through the ERK and the phophati
85 regulin-beta1 and EGF was Src-dependent, and heregulin-beta1 stimulation of Bmx was also PI 3-kinase-
87 CaP cells were markedly decreased by EGF and heregulin-beta1, and experiments with actinomycin D to b
88 VEGF expression are positively regulated by heregulin-beta1, we hypothesized that Pak1 regulates VEG
92 iogenesis, our studies suggest that blocking heregulin-beta1-mediated activation of MMP-9 by inhibiti
96 Herceptin, an anti-HER2 antibody inhibited heregulin-beta1-mediated stimulation of both VEGF expres
97 we found that WWP1 negatively regulates the heregulin-beta1-stimulated ErbB4 activity as measured by
108 e kinase homo- and heterodimerizes following heregulin binding, which provokes increased levels of ty
112 h factors in the mammary gland, we show that heregulin but not her2/neu, c-Myc or v-Ha-ras plays a ma
117 UM102 cells resulted in the acquisition of a heregulin-dependent antiproliferative response, associat
120 esults indicate that patritumab can overcome heregulin-dependent EGFR inhibitor resistance in NSCLC i
121 olutionary conserved tyrosine 1114 site in a heregulin-dependent manner, even in the presence of tamo
127 kinase activity is stringently required for heregulin-dependent, but not 12-O-tetradecanoylphorbol-1
130 g the epidermal growth factor-like region of heregulin ectodomain for 3 months in vivo resulted in up
131 and pharmacologic inhibition of JNK impaired heregulin-enhanced expression of BRCA1 and mitotic delay
132 atment of cells with EGF (ErbB1-specific) or heregulin (ErbB4-specific) resulted in a hierarchic tran
134 Patritumab sensitivity was associated with heregulin expression, which, when abolished, resulted in
136 UB branching morphogens (i.e., pleiotrophin, heregulin, FGF1 and GDNF) were found to have a higher af
137 pathway involved in the survival function of heregulin, focusing on heregulin-induced changes in Akt
138 -4 cells with epidermal growth factor (EGF), heregulin, Gas6 (ligand binding to the Mer receptor tyro
140 for VEGF induction and tumor angiogenesis by heregulin-HER2 signaling and establish a novel mechanism
142 th factor receptor (HER) 3 (ErbB3), blocking heregulin (HRG) -mediated ErbB3 signaling and inducing E
145 s blocked by an antibody against HER-2 or by heregulin (HRG) depletion from the conditioned medium th
149 We have previously shown that expression of heregulin (HRG) is closely correlated with breast cancer
155 cells with epidermal growth factor (EGF) or heregulin (HRG) results in marked upregulation of MUC1-C
156 GF receptor HER-2 (erbB2) leads to amplified heregulin (HRG) signaling, promoting more aggressive bre
158 phila S2 cells, binds the EGF-like domain of heregulin (hrg) with a K(d) of 1.9 nM as measured by sur
159 pha(v)beta(3) integrin and overexpression of Heregulin (HRG), a growth factor associated with breast
160 reast cancer cells exhibiting high levels of Heregulin (HRG), a growth factor closely associated with
161 In concert with these results, we show that heregulin (HRG), a ligand for ErbB receptors, activates
167 tivation by epidermal growth factor (EGF) or heregulin (HRG), significantly improves prediction of ce
168 subset of the cell lines for Src-dependent, heregulin (HRG)-augmented, anchorage-dependent and indep
170 vestigate these mechanisms, we observed that heregulin (HRG)-mediated activation of HER2, or HER2 ove
171 (sErbB3), is a potent negative regulator of heregulin (HRG)-stimulated ErbB2, ErbB3, and ErbB4 activ
172 ely regulates crosstalk between ErbB3 ligand heregulin (HRG)-triggered signaling and the AR axis, aff
177 al, addition of the ErbB3/ErbB4 ligand alpha-heregulin (HRG; 1-100 ng/ml) inhibited secretory respons
180 nvestigate further the signaling pathway for heregulin in glial cells, BAD was overexpressed in C6 gl
181 ting pathways of G(2)/M delay, we noted that heregulin increased the expression of BRCA1 in a HER4-de
182 regulin 1 (or NRG1, hereafter referred to as heregulin) increased CXCR4 expression in breast cancer c
184 Based on these results, we propose that heregulin increases the expression of pro-invasive, pro-
187 ls and primary cultures of oligodendrocytes, heregulin induced time- and dose-dependent Akt phosphory
189 nd blocks epidermal growth factor (EGF)- and heregulin-induced activation of Rac GTPase, extracellula
190 ErbB3 that results in increased basal and/or heregulin-induced activation of receptors, and their dow
193 etreatment of SKBr3 cells with ID5 decreased heregulin-induced association of HER2 with HER3 as well
194 vels blocked a significant proportion of the heregulin-induced cell cycle progression in LNCaP cells.
195 tion of Pten was able to inhibit ErbB-2- and heregulin-induced cell cycle progression, as well as cyc
196 survival function of heregulin, focusing on heregulin-induced changes in Akt activity in cultured gl
202 nt acidification of endosomes were employed, heregulin-induced ErbB-4 cleavage was sensitive to metal
204 kinase pathway in SKBr3 cells did not affect heregulin-induced G2-M-phase arrest, apoptosis, and diff
206 with submicromolar affinities and to inhibit heregulin-induced interactions of erbB3 with different e
209 ediated PI3-kinase signaling is critical for heregulin-induced motility, and therefore crucial for Er
212 translated region of HIF-1alpha mRNA directs heregulin-inducible expression of a heterologous protein
214 which anti-p185HER2 antibody and the ligand heregulin inhibit tumor growth, we have investigated sev
218 This study demonstrates that transmembrane heregulin is functionally active and suggest it is capab
219 t data suggest that the survival function of heregulin is mediated through the PI-3 kinase/Akt pathwa
224 cells (Her-2 +/-) engineered to overexpress heregulin (MCF-7/HRG), a ligand for the Her-2/3/4 networ
228 inhibitor of I kappa B-kinase (IKK), blocked heregulin-mediated activation of NF-kappa B and cell pro
229 as the depletion of Pak1 interferes with the heregulin-mediated dephosphorylation of cofilin, the dep
230 athrin-coated pit formation, suggesting that heregulin-mediated ErbB-4 cleavage occurs subsequent to
231 c localization of utrophin occurs in part by heregulin-mediated extracellular signal-regulated kinase
235 b, the tyrosine kinase inhibitor, suppressed heregulin-mediated p185(c-neu)/ErbB3 signaling to PRL.
237 e related to focal adhesion kinase (FAK), in heregulin-mediated signal transduction in breast cancer
239 The amelioration of dystrophic phenotype by heregulin-mediated utrophin up-regulation offers a pharm
240 A is transcriptionally regulated in part by heregulin-mediated, extracellular signal-related kinase-
241 geted corrole noncovalently assembled with a heregulin-modified protein directed at the human epiderm
245 ll line Ben-Men-1, particularly neuregulin-1/heregulin (NRG1), and confirm increased NRG1 secretion a
247 onditions, as well as the in vivo effects of heregulin on human cells growing in nude mice to address
249 fragment is generated by cell treatment with heregulin or 12-O-tetradecanoylphorbol-13-acetate, the f
251 lts indicate that the activation of ErbB2 by heregulin or by its overexpression requires Grb2 to stim
252 reatment of LNCaP and LAPC-4 cells with EGF, heregulin or Gas6 induced AR phosphorylation at Tyr-267,
259 he Mr 46,000 isoform of SHC to HER2, whereas heregulin preferentially induced binding of the Mr 52,00
260 ing heregulin receptors are co-cultured with heregulin-producing cells, specific in vivo associations
263 in several tumor cells lines the addition of heregulin results in the translocation of ErbB-4 to a de
264 mains unclear because its activating ligand, heregulin, results in either proliferation or differenti
266 clonal antibody 2C4 inhibited all aspects of heregulin signaling as well as anchorage-independent and
270 otein inhibition led to growth inhibition of heregulin-stimulated breast cancer cells, but not Erk1,2
273 tion of Pak1 decreases phospho-MLC levels in heregulin-stimulated cells, the depletion of Pak2 enhanc
275 Anti-ErbB2 monoclonal antibody 2C4 blocked heregulin-stimulated phosphorylation of ErbB2 and ErbB3;
279 trast to other inducers of HIF-1 expression, heregulin stimulation does not affect the half-life of H
282 uced by overexpression in mouse 3T3 cells or heregulin stimulation of human MCF-7 breast cancer cells
288 tivation of p185(c-neu)/ErbB3 signaling with heregulin, the ErbB3 ligand, in rat lacto-somatotroph (G
289 e to breast carcinoma invasion stimulated by heregulin, these roles are mediated by distinct signalin
291 ated receptor agonist, acted in synergy with heregulin to induce massive cell death in breast cancer
292 ated and associated with PI3K activity after heregulin treatment and that Gab1 and Gab2, but not ErbB
293 ly lack mesenchyme formation, are rescued by heregulin treatment, which restores phosphorylation of E