ライフサイエンスコーパス: heritability

1 in a trait explained by genotyped SNPs (SNP-heritability).

2 ed risk loci explain a small fraction of AAA heritability.

3 Epigenetics may in part facilitate heritability.

4 c inheritance is emerging as a mechanism for heritability.

5 l type-specific enrichments of complex trait heritability.

6 ntergenic regions account for the most trait heritability.

7 tecture and explain over half of the disease heritability.

8 ive variable, or traits with relatively high heritability.

9 linear environmental score (ES) and its GxE heritability.

10 c units (OTUs), Families and Phyla with high heritability.

11 eded to identify loci accounting for genetic heritability.

12 ld be a major cause of prostate cancer (PCa) heritability.

13 fraction of the common variant attributable heritability.

14 e loci explain only a small proportion of AF heritability.

15 terized by a complex genetic trait with high heritability.

16 y implicated, jointly explaining 8.2% of CAD heritability.

17 the total ASD single nucleotide polymorphism heritability.

18 of reliable and accurate methods to estimate heritability.

19 related to leaves, stems and roots with high heritability.

20 hods with accuracies approaching the trait's heritability.

21 s was substantially higher than narrow-sense heritability.

22 gression approach (LEMMA) for estimating GxE heritability.

23 t contribution of regulatory elements to EOC heritability.

24 w skeletal muscle, a complex trait with high heritability.

25 vant, cannot explain the majority of disease heritability.

26 e and is a conjectured source of substantial heritability.

27 50 years), learning slope showed significant heritability.

28 of traits, such as genetic correlations and heritabilities.

29 Across traits, broad-sense heritability (0.4-0.8) was relatively high.

30 evealed strong broad- and narrow-sense trait heritability (0.82 and 0.41, respectively).

31 y the base model, which accounted for a high heritability (61.78%).

32 Nicotine dependence (SNP-based heritability = 8.6%) is genetically correlated with 18 o

33 idual differences in educational attainment (heritability: a(2) = 0.43; 0.41-0.44), but also environm

34 Partitioning heritability across 28 functional annotations, we observ

35 c chromatin data explain a large fraction of heritability across a broad set of diseases and correspo

36 Partitioned SNP heritability across broad functional categories indicate

37 stimate single-nucleotide polymorphism (SNP)-heritability among distantly related individuals with un

38 Heritability analyses found additive genetic effects exp

39 should be especially useful for large-scale heritability analyses in the genomics era.

40 Finally, heritability analyses revealed mutual eye gaze to be mod

41 The heritability analysis indicated that common SNPs account

42 has persisted in the population with a high heritability and a stable prevalence.

43 However, the heritability and association of family history with late

44 timating genetic parameters, such as disease heritability and between-disease genetic correlations, d

45 ding annotations explain substantial disease heritability and can help refine genome-wide association

46 ulticenter study of CASQ2-CPVT redefines its heritability and confirms that pathogenic heterozygous C

47 ng structure may be an important mediator of heritability and determinant of personalized COPD risk.

48 of genetic programs that modify cis-mediated heritability and disease risk.

49 cidence and prognosis of AD and estimate the heritability and environmental contribution in AD in Tai

50 old model was used to examine the effects of heritability and environmental factors.

51 netic and maternal factors equating with low heritability and evolvability.

52 model approach, we estimate partner indirect heritability and find evidence of partner heritability o

53 well as single-nucleotide polymorphism (SNP) heritability and genetic correlation estimation using li

54 e nucleotide polymorphism-based estimates of heritability and genetic correlation relate to those est

55 de gene-based tests and characterize the SNP heritability and genetic correlations between these trai

56 With genetic nurturing, interpreting heritability and hence the meaning of "missing heritabil

57 associated genetic variants explain 18.4% of heritability and improve the accuracy of myopia predicti

58 ractions, which can be useful for explaining heritability and invaluable for determining biologically

59 tic variation, resolving some of the missing heritability and leading to the discovery of novel mecha

60 te, but less so for others because of modest heritability and lower incidence.

61 l of the physical mechanisms that govern the heritability and maintenance of epigenetic modifications

62 both study populations, accounting for 9% of heritability and modifying age of diagnosis as well as a

63 dies (GWAS) and comprehensive evaluations of heritability and pleiotropy across 18 cancer types in tw

64 developed so far for estimating dynamic SNP-heritability and quantifying its full uncertainty.

65 We found significant heritability and shared environment for a number of como

66 ments were strongly associated with PCa risk heritability and somatic mutation density.

67 h likely explains male-female differences in heritability and some gene-environment interactions.

68 enomic regions play different roles in trait heritability and which region is more responsible for ph

69 es revealed significant genetic variance and heritability, and an antagonistic genetic correlation wi

70 with biobank-scale Mendelian randomization, heritability, and genetic correlation analyses.

71 e best GRS explains approximately 75% of SNP-heritability, and individuals in the top decile of GRS h

72 Bipolar disorder has a high heritability (approximately 70%).

73 10(-16)); and (3) the disease onset age and heritability are negatively correlated (rho = -0.46, p <

74 r estimating dynamic variance components and heritability as their function.

75 k genes account for a significantly enriched heritability, as estimated by stratified linkage disequi

76 ritability and hence the meaning of "missing heritability" becomes problematic.

77 We observed partially shared heritability between 25OHD and socio-economic traits, a

78 its, we show systematic differences in trait heritability between European and African populations, p

79 IMPACT annotations captured consistent SNP heritability between populations, suggesting prioritizat

80 vastating neuropsychiatric disease with high heritability but few genes identified.

81 line genomic signatures has implications for heritability, but its impact on targeted therapies has n

82 annotations were highly enriched for disease heritability, but produced only limited conditionally si

83 se acting on estimates of genuinely positive heritability, but we argue that they may also arise from

84 rthritis variants that contribute to disease heritability by tending to modify constrained functional

85 Here we show that genome-wide SNP-heritability can be accurately estimated from biobank-sc

86 ed to estimate additive genetic effects (the heritability), common/shared environmental, and unique/n

87 tabolic pathways and tend to have higher SNP heritability compared to non-eGenes.

88 e 28 GRNs (each contributing to >0.2% of CAD heritability) comprised 24 to 841 genes, whereof 1 to 28

89 The heritability contribution of gene regulatory networks (G

90 r CHIP mutations overall, and no significant heritability could be detected.

91 ize progress to date including dissection of heritability, discovery of vitiligo susceptibility loci

92 ait, the distribution of locus effect sizes, heritability, dominance, and epistasis.

93 ilitating the illumination of common disease heritability enrichment across an array of human phenoty

94 ute) performed best, with an 58% increase in heritability enrichment compared to the chromatin marks

95 isequilibrium score regression and evaluated heritability enrichment in 64 genome-wide association st

96 endothelial cells by using gene mapping and heritability enrichment.

97 tional categories and find evidence that SNP-heritability enrichments are driven largely by many low-

98 .67), and adjustment for this attenuated the heritability estimate (42%).

99 The liability scale common variant heritability estimate for Lifetime Anxiety Disorder was

100 mood instability were identified with a SNP heritability estimate of 9%.

101 Heritability estimated by both approaches was exceedingl

102 Heritability estimates (+/-SE) of Operational Taxonomic

103 uld be open to the possibility that negative heritability estimates could reflect a real physical fea

104 isition is polygenic and heritable, with SNP heritability estimates explaining 28-42% of the variance

105 urrently available that can produce unbiased heritability estimates for sequencing count data.

106 A quarter of variants had heritability estimates greater than 10% with most herita

107 r (PD) has a lifetime prevalence of 2-4% and heritability estimates of 40%.

108 P and phytic acid (PA), and (3) broad-sense heritability estimates of P concentrations.

109 We identified significant and comparable heritability estimates of suicide attempt from both the

110 Heritability estimates of the geometric quantities alone

111 Heritability estimates of VS traits, vulva area (VA), he

112 Heritability estimates range from 0.32 to 0.63.

113 Broad sense heritability estimates revealed low to moderate inherita

114 SNP-based heritability estimates suggest that roughly 60% of the p

115 t EF has an important genetic component with heritability estimates up to 0.61, to date only 6 EF-ass

116 With this model, heritability estimates were 0.26 for honey yield, 0.36 f

117 Single-nucleotide polymorphism-based heritability estimates were more than three times larger

118 ghly Sensitive Child (HSC) questionnaire and heritability estimates were obtained using classic twin

119 unt data), to enable effective and efficient heritability estimation and differential analysis using

120 related traits, it is meaningful to base SNP-heritability estimation on longitudinal data due to the

121 for unequal relatedness between individuals, heritability estimation, and including covariates when t

122 nstruct the genealogy of this population for heritability estimation.

123 Moreover, heritability estimators provided by existing methods may

124 The identified SNPs explained nearly all the heritability expected for character in each sample (50 t

125 The identified SNPs explained nearly all the heritability expected in each sample (37-53%) despite va

126 The proportion of genome-wide chip heritability explained by all known susceptibility loci

127 In this study we first estimated the heritability explained by known common low penetrance ri

128 t identified loci increase the percentage of heritability explained, from 33.5% to 62.6%.

129 ronmental Sensitivity (ES) by estimating its heritability, exploring the presence of multiple heritab

130 We provide estimates of SNP-heritability for 22 complex traits in the UK Biobank and

131 The estimated heritability for 640 metabolites ranged between 0%-54% w

132 imated single nucleotide polymorphisms (SNP) heritability for a suicide attempt.

133 , which account for an average of 75% of the heritability for each trait.

134 obsessiveness.There was evidence of moderate heritability for impulsivity (A(2) = 0.33), modest addit

135 epresents a unique opportunity to assess GxE heritability for many traits and diseases in a well powe

136 The estimated heritability for MDC was essentially null (2%; 95% CI, -

137 ], [Formula: see text]), while the estimated heritability for Reynolds number calculated using the ab

138 The study showed high heritability for survival (SUR) under all three phenotyp

139 Significant heritability for survival were found for all time points

140 a bifactor modelling approach and estimated heritability for their shared and unique phenotypic vari

141 that exome data alone will miss much of the heritability for these traits-i.e., existing PRS cannot

142 g there is essentially no remaining 'missing heritability' for vitiligo.

143 local flow during systole showed substantial heritability ([Formula: see text], [Formula: see text]),

144 it methods to multiomics data to dissect the heritability found in GWASs.

145 We used posterior mean per-SNP heritabilities from PolyFun + SuSiE to perform polygenic

146 Finally, we used heritability, gene-set enrichment, and transcriptome-wid

147 Here we report heritability, genetic correlations and genome-wide assoc

148 High estimates of heritability (> 0.81) were observed for Fe, Zn, Ca, P, M

149 ht loss is a heritable trait, with estimated heritability (h (2) = 0.49) within the range reported fo

150 lculated near-zero estimates of narrow sense heritability (h (2)), which suggest that variation in DN

151 Broad-sense heritability (H(2) ) ranged from 0.30 to 0.56 for morpho

152 ) = 0.50, P < 0.001) and demonstrated robust heritability (h(2) , 0.36; 95% confidence interval [CI],

153 Total additive genetic heritability (h(2)) of the annual rate of change in thes

154 Quantile-specific heritability (h(2)), estimated by 2beta(OP)/(1 + r(spous

155 The narrow sense heritability (h(g)(2)) of EOC overall and high-grade ser

156 SNP heritability (h(snp)(2)) estimates were ~10%, and both t

157 We estimated family-based heritability (h2FAM) by vitiligo recurrence among a tota

158 We estimated genotype-based heritability (h2SNP) by deep imputation to Haplotype Ref

159 Over 50% of late-onset AD heritability has been captured, allowing researchers to

160 study were to estimate and compare vitiligo heritability in European-derived patients using both fam

161 tional annotations, we observe enrichment of heritability in FANTOM5 enhancers in asthma, eczema, thy

162 an explain only a small fraction of lifespan heritability in humans.

163 upported by the observation that broad-sense heritability in hybrids was substantially higher than na

164 mary, we have confirmed previous findings of heritability in MD, and also established heritability of

165 To identify missing heritability in PAH we integrated deep phenotyping with

166 e important role than genic regions in trait heritability in rice, which is consistent with findings

167 An analysis of heritability in the functionally partitioned rice genome

168 ndent, and whether this explains the greater heritability in women than men in accordance with their

169 relations and single-nucleotide polymorphism heritabilities inferred from GWAS summary statistics of

170 tic variation in TF-binding sites to disease heritability is challenging, as binding is often cell ty

171 n at least ~25% of these traits, the partner heritability is consistent with the existence of indirec

172 We propose that most heritability is driven by weak trans-eQTL SNPs, whose ef

173 genome-wide association study (n = 461,106) heritability is estimated at 8.2% (95% CI: 6.4%, 9.9%).

174 s, a significant proportion of estimated SLE heritability is not accounted for by common disease alle

175 ons are strongly related to adiposity, whose heritability is quantile dependent.

176 raits (average N = 361k), we determined that heritability is spread ~4x more evenly among common SNPs

177 sk attributable to genetic variation, termed heritability, is high, with estimates from family studie

178 The heritability levels of two traits for diabetes diagnosis

179 ters were identified, which had estimates of heritability lying between 41.9% and 54.3%.

180 score regression (MESC), to estimate disease heritability mediated by the cis genetic component of ge

181 Heterochromatin heritability might allow wild-type cells under certain c

182 boosted scores also produce improvements in heritability model fit and in classifying disease-associ

183 f genetic architecture, without specifying a heritability model or partitioning SNPs by allele freque

184 ncidences of SCZ and BIP were used to inform heritability models for these disorders.

185 rovide a statistical framework for assessing heritability models using summary statistics from genome

186 model is more realistic than other existing heritability models, but that it can be improved by inco

187 mon, complex psychiatric disorders with twin heritabilities of 30-60%.

188 ally accounting for genetic correlations and heritabilities of the traits in the association test.

189 ins considerable and twin studies estimate a heritability of >45% for nephrolithiasis and >50% for hy

190 rongly associated with host genetic with the heritability of 0.776 in bovine MDM and 0.8 in mouse per

191 We then partitioned the common SNP heritability of 111 genome-wide association study summar

192 e single-nucleotide polymorphism (SNP)-based heritability of 12 subfields, as well as their genetic c

193 We estimated an SNP-based heritability of 20-25% for DD, and observed significant

194 tissues, and to investigate the partitioned heritability of 25OHD and its shared heritability with o

195 Using this approach, the SNP heritability of 25OHD was estimated to 16.1%.

196 sorder affecting the ability to read, with a heritability of 40-60%.

197 We partitioned the heritability of 49 diseases and complex traits using str

198 p-value-based tests for detecting minor QTL (heritability of 5-10%) and is competitive with regard to

199 nd autism spectrum disorders exhibited a SNP heritability of 5.6% [CI-95: 1.9-9.3%] and 9.6% [CI-95:

200 r's disease (AD), with late-onset AD showing heritability of 58-79% and early-onset AD showing over 9

201 ADHD's high heritability of 74% motivated the search for ADHD suscep

202 nding of genetic architecture underlying the heritability of a trait.

203 The heritability of AD was estimated to be 57.0% for genetic

204 re partly determined by genetic factors; the heritability of ADHD is estimated at 70-80% and of canna

205 ciated genes significantly contribute to the heritability of anxiety, major depressive disorder, obse

206 riants together account for about 25% of the heritability of BD.

207 ly approximately 27% of the 30-50% estimated heritability of blood pressure, and the effect of each S

208 We have evaluated SNP-based heritability of BPH in two cohorts and conducted a genom

209 ifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive.

210 Here, we report high heritability of calcification rate among the eight most

211 Broad sense heritability of calcification rates was high among all e

212 tually dominating the population, due to the heritability of cell-cycle phases.

213 n single cells and suggests that non-genetic heritability of cellular state may be a quantitative pro

214 The heritability of chromatin states through cell division i

215 The heritability of common psychiatric disorders has motivat

216 Heritability of CT was 35% when estimated across environ

217 ome-wide association studies to estimate the heritability of cutaneous psoriasis, psoriasis vulgaris

218 We show that the heritability of dental caries is enriched for conserved

219 Here, we estimated the heritability of developmental change in white matter tra

220 nd which may determine key components of the heritability of distinctive disease traits including ste

221 We investigated the heritability of educational attainment and how it differ

222 flow may increase risk, we investigated the heritability of fluid metrics in the ascending aorta cal

223 only limited insights, leaving the observed heritability of HF largely unexplained.

224 result, it is currently unclear whether the heritability of host-associated microbiomes follows simi

225 Heritability of human lifespan is 23-33% as evident from

226 with common alleles better explain apparent heritability of human lifespan.

227 r maternal effects might explain the missing heritability of late-onset human diseases, such as Alzhe

228 guppy (Poecilia reticulata) to quantify the heritability of leadership in a cooperative context, and

229 The estimated heritability of liability for SCZ (h(2) = 0.62, 95% conf

230 e demonstrate significant enrichments of the heritability of major depressive disorder, obsessive-com

231 rare genetic variations have documented the heritability of major psychiatric disorders, established

232 The genomic heritability of maleness ranged between 0.48 and 0.62 de

233 The heritability of mammographic features such as dense area

234 The SNP-based heritability of MDD with reported trauma exposure (24%)

235 These findings provide novel data on the heritability of microcalcifications, masses, and density

236 do not fully account for the relatively high heritability of neurodevelopmental conditions, suggestin

237 X-variant heritability of neuroticism was estimated at 0.22% (SE =

238 microbiomes follows similar patterns to the heritability of other complex traits.

239 The single nucleotide polymorphism-based heritability of overall motor development was 20% (SE =

240 modules, and a significant enrichment of the heritability of Parkinson's disease within the substanti

241 Heritability of passive immunity associated traits (rang

242 Genetic heritability of PAU was enriched in brain and in conserv

243 r 14% of variation in perceived age, and the heritability of perceived age was partially shared with

244 Better elucidation of the heritability of psoriatic disease subsets is important f

245 Furthermore, the enrichment of the heritability of psychiatric disorders in the co-expressi

246 EDU/SES significantly affected the observed heritability of psychiatric traits, ranging from 2.44% h

247 The heritability of PTC is high compared to other cancers, b

248 Heritability of QT dynamics during exercise and recovery

249 gonistic variation due to asymmetries in the heritability of recessive traits in the homogametic vers

250 Heritability of SBP and DBP ranged from 16.8% to 40.4% f

251 Results indicate that the heritability of sensitivity was 0.47, and that the genet

252 Family studies have estimated substantial heritability of suicidal behavior; however, collecting t

253 s on the contribution of GGIs to the overall heritability of T2D.

254 s Maori and Pacific children may reflect the heritability of telomere length in genetically less comp

255 However, we do not know the heritability of the development of the neural substrates

256 responsible for most of the common variation heritability of the disease.

257 Relevant heritability of the microbiome included Actinomyces and

258 of heritability in MD, and also established heritability of the number of microcalcifications and ma

259 We examined heritability of the plasma lipidome among healthy older-

260 wever, practical methods to accurately track heritability of the trait are lacking.

261 tibility, we present evidence supporting the heritability of this phenotype, have identified suggesti

262 ell as genotypic effects that support a high heritability of this trait were observed.

263 with growth and fatness, ii) to estimate the heritability of those features, and, iii) to conduct a g

264 However, the regulation and heritability of transcriptional memory in single cells a

265 s, we show that m(6)A QTLs contribute to the heritability of various immune and blood-related traits

266 A moderate genomic heritability of viral load at 4 weeks (0.15-0.21) and a

267 ct heritability and find evidence of partner heritability on ~50% of the analysed traits.

268 dum that were significantly enriched for BMI heritability (p<1.6x10(-4)).

269 ain only a small proportion of breast cancer heritability, particularly in Asian women.

270 riation and environmental factors impact DCM heritability remains unclear.

271 A notable part of this heritability remains unexplained, and large genetic stud

272 markedly enhance the genetic association and heritability signals of diseases and traits.

273 - 0.13, p = 9.07 x 10(-7)) and a sizable SNP heritability (SNP h(2) = 0.21 +/- 0.02) for the cross-di

274 nable genetic analysis of traits with modest heritability, such as diet.

275 Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across t

276 tation showed single nucleotide polymorphism heritabilities that ranged from 5 to 11%.

277 DD): the former has a lower genotype-derived heritability that cannot be explained by inclusion of mi

278 owever, there is still a large proportion of heritability that might be explained by rare but functio

279 ing negative maximum likelihood estimates of heritability that sometimes arise from popular statistic

280 omic findings to date account for ~30% of AD heritability, therefore, considerable further work is ne

281 n SNPs causally explaining 50% of common SNP heritability; these sets ranged in size from 28 (hair co

282 Controlling for mental disorders reduced the heritability to 1.9% [CI-95: 0.3-3.5%].

283 We estimated the broad-sense heritability to be 50-60% for all examined traits, and w

284 There is heritability to interindividual variation in platelet co

285 sCJD but, although the condition has similar heritability to other neurodegenerative disorders, no ot

286 of twin data and new methods for estimating heritability using measured DNA.

287 ant, gene, and pathway level, and estimating heritability using single-nucleotide polymorphism (SNP)

288 much debate regarding the best model for how heritability varies across the genome.

289 sample sizes required to explain 80% of GWAS heritability vary from 60,000 cases for testicular to ov

290 Expression-mediated heritability was enriched in genes with evidence of sele

291 Heritability was estimated at 58% [95% confidence interv

292 Suicide death heritability was estimated at an h(2)(SNP) value of 0.25

293 Heritability was estimated using pedigree-based (QTDT) a

294 Significant heritability was found for the rates of change of 6 whit

295 or older to confirm finalized education, the heritability was higher in the older cohorts born in 190

296 Averaging across traits, only 11 +/- 2% of heritability was mediated by assayed gene expression lev

297 are significantly enriched for schizophrenia heritability with maximal enrichment in cortical layer V

298 itioned heritability of 25OHD and its shared heritability with other traits.

299 soriatic arthritis both exhibit considerable heritability, with a greater contribution coming from cu

300 We further investigated enrichment of heritability within 2,868 annotations of genome-wide tra