ライフサイエンスコーパス: heterodimer

1 match recognition factor MutSbeta (MSH2-MSH3 heterodimer).

2 tructure of the Ctf3c bound to the Cnn1-Wip1 heterodimer.

3 activity of MDM2 homodimer but not MDM2-MDMX heterodimer.

4 one homodimer species without affecting the heterodimer.

5 iated with the four Ca(2+)-binding sites per heterodimer.

6 esidues at the membrane distal region of the heterodimer.

7 lin-like receptors (KIRs) and the NKG2A/CD94 heterodimer.

8 ecifically engage the interleukin-4 receptor heterodimer.

9 to the specific enrichment of an HspB1-HspB6 heterodimer.

10 a single subunit to yield the mature p66/p51 heterodimer.

11 s 2 forms, alphaalpha homodimer or alphabeta heterodimer.

12 TCRgamma, canonically found in the TCRdelta heterodimer.

13 the E1 protein, the E2 protein, or the E1E2 heterodimer.

14 arget for the NR4A-retinoid X receptor (RXR) heterodimer.

15 rmation of an AFF4 homodimer or an AFF1-AFF4 heterodimer.

16 ap domain of T1R2 subunit of the sweet taste heterodimer.

17 ethered to the thylakoid membrane by the OHP heterodimer.

18 ers are less stable than the unmodified holo-heterodimer.

19 uman APCs by signaling through the TLR1/TLR2 heterodimer.

20 rface expression of the alphaVbeta3 integrin heterodimer.

21 r and holo GLRX5:BolA-like protein 3 (BOLA3) heterodimer.

22 's motility to reproduce the behavior of the heterodimer.

23 the crystal structure of the core pUL7:pUL51 heterodimer.

24 omodimerization interface into complementary heterodimers.

25 perative assembly process of heavy chains in heterodimers.

26 o subunits can spontaneously form functional heterodimers.

27 and CD8beta, which can assemble into homo or heterodimers.

28 dimer stability and monomer exchange between heterodimers.

29 tive androstane receptor-retinoid X receptor heterodimers.

30 ast some of these substrates are secreted as heterodimers.

31 ates of differing lengths bound by POT1-TPP1 heterodimers.

32 ydrocarbon yield is achieved compared to the heterodimers.

33 ulatory elements as monomers, homodimers, or heterodimers.

34 y MutS homolog (MSH) mismatch repair protein heterodimers.

35 n of long spiral ribbons from GMPCPP tubulin heterodimers.

36 placing MYC/MAX heterodimers with Omomyc/MAX heterodimers.

37 can exchange with added tubulin to form new heterodimers.

38 dimers, allowing exchange between homo- and heterodimers.

39 ha in cells and form inactive, heme-free sGC heterodimers.

40 inding depends on the formation of OHP1/OHP2 heterodimers.

41 cyto anti-HIV-1 activity of the Trojan horse heterodimers.

42 endocytic machinery come together to form a heterodimer?

43 trations to decelerate GCAP-activated RetGC1 heterodimer-6-fold higher than WT and 2-fold higher than

44 n the monoubiquitination of the FANCI-FANCD2 heterodimer, a central step in the Fanconi anemia (FA) p

45 The MEKK1 TOG domain binds to tubulin heterodimers-a canonical function of TOG domains-but is

46 During gastrula stages, TFAP2A/C heterodimers activate components of the neural plate bor

47 The U2AF heterodimer also has a noncanonical function as a transl

48 nto different conformations by a WDR60-WDR34 heterodimer and a block of two RB and six LC8 light chai

49 tein kinase (DNA-PK), which comprises the KU heterodimer and a catalytic subunit (DNA-PKcs), is a cla

50 the nucleotide-bound ECs lack the A49-A34.5 heterodimer and adopt a Pol II-like conformation, in whi

51 y a coevolved module between the EDS1-SAG101 heterodimer and coiled-coil (CC) HET-S and LOP-B (CC(HEL

52 nding stoichiometry to be four Ca(2+) per CP heterodimer and eight Ca(2+) per CP heterotetramer, (iii

53 SN2/CSN4, release of the catalytic CSN5/CSN6 heterodimer and finally activation of the CSN5 deneddyla

54 fers calcineurin-dependent regulation to the heterodimer and gives rise to a pharmacological profile

55 an inhibitory mode that holds the Rag GTPase heterodimer and has previously been captured by structur

56 kinase (DNA-PK), which is composed of the KU heterodimer and the large catalytic subunit (DNA-PKcs),

57 J factor that encompasses the Ku70-Ku80 (KU) heterodimer and the large DNA-PK catalytic subunit (DNA-

58 show that all 10 capsid proteins (from four heterodimers and two homodimers) have obvious structural

59 These hetero-hexamers are built from heterodimers and utilise a jigsaw-puzzle system of pegs

60 Ubc9*Pdr6 import complex, of the RanGTP*Pdr6 heterodimer, and of the trimeric RanGTP*Pdr6*eIF5A expor

61 inding, formation of homodimer of alpha-beta heterodimers, and cholesterol binding in the cell membra

62 cally stable RAF dimers, suggesting that RAF heterodimers, and not homodimers, are the major players

63 in Escherichia coli, 65 formed constitutive heterodimers, and the crystal structures of four designs

64 structure and function in the RTY homo- and heterodimers, and unveiled the likely structural basis o

65 Simulations also indicate that HNG-IAPP heterodimers are 10 times more stable than IAPP homodime

66 Coiled-coil heterodimers are an exception, but the restricted geomet

67 Four functionally distinct alphabeta heterodimers are assembled from only five subunits to re

68 The oxidized heterodimers are less stable than the unmodified holo-he

69 BMP7/BMP2 or BMP7/BMP4 heterodimers are more active than homodimers in vitro, b

70 We found that B/CRAF heterodimers are the most thermodynamically stable RAF d

71 nservation, we first identified the INTU/FUZ heterodimer as a novel member of homologous HerMon (Herm

72 Nuclear receptors (NRs) form homo- and/or heterodimers as central scaffolds of multiprotein comple

73 iprovocim induced the formation of TLR2/TLR1 heterodimers as well as TLR2 homodimers in vitro.

74 In turn, two such heterodimers assemble into a tetramer both in the crysta

75 C37/53 is related to heterodimers associated with RNAPs I and II, and C11 is

76 astaneum in complex with a human MICU1-MICU2 heterodimer at 3.3 angstrom resolution.

77 e cryo-EM structure of the human LAT1-CD98hc heterodimer at 3.3- angstrom resolution.

78 re consistent with the formation of parallel heterodimers at concentrations below a synergistic incre

79 tionally relevant in the unloading of PE-PPE heterodimers at the secretion machinery.

80 gle x-ray scattering data supports a compact heterodimer between the CTL domains.

81 Exclusive heterodimers between EDS1 and SAG101 or PAD4 create esse

82 Myc/Max heterodimers bind to E box sequences in the promoter reg

83 ntrast to allosteric activation by RHEB, Rag heterodimer binding does not change mTORC1 conformation

84 es; however, it only moderately impaired the heterodimer binding to long ssDNA substrates containing

85 Remarkably, the U2AF heterodimer binds weak, uridine-poor Py tracts as a mixt

86 We determined the structures for nsp16-nsp10 heterodimers bound to the methyl donor S-adenosylmethion

87 ers, including BRAF homodimers and BRAF-CRAF heterodimers, but not CRAF homodimers or ARAF-containing

88 f 300 nm We created a molecular model of the heterodimer by comparison with the Sphingomonas sp. A1 M

89 04) promotes nuclear accumulation of PER-TIM heterodimers by inhibiting the interaction of TIM and nu

90 Additionally, we show that BRAF(D594G):CRAF heterodimers bypass autoinhibitory P-loop phosphorylatio

91 s examine the architecture of the Rag GTPase heterodimers complexed with mTORC1.

92 e enzyme soluble guanylyl cyclase (sGC) is a heterodimer composed of an alpha subunit and a heme-cont

93 Furthermore, one of these heterodimers, composed of ATF4 and CCAAT enhancer-bindin

94 stream form (BSF) of Trypanosoma brucei is a heterodimer comprising glycosylphosphatidylinositol (GPI

95 ate heterodimer consisting of alpha and beta heterodimer conserved from yeast to human.

96 CapZ is an obligate heterodimer consisting of alpha and beta heterodimer con

97 Katanin, a heterodimer, consisting of catalytic (p60) and regulator

98 sm where reversible binding of the A49-A34.5 heterodimer could contribute to the regulation of Pol I

99 of female infertility, but, as a noncovalent heterodimer, cumulin is difficult to produce and purify

100 stablishment; however, reliance on Oct4/Sox2 heterodimers declines during pluripotency maintenance.

101 gions on a hydrophobic face of the K1/K10-1B heterodimer dictated tetramer assembly: the N-terminal h

102 sxA and its chaperone EsxB are secreted as a heterodimer (EsxA:B) and are crucial for mycobacterial e

103 1 exists in monomer or homodimer but forms a heterodimer exclusively with XPB.

104 tation assays confirm that endogenous BMP4/7 heterodimers exist.

105 activity of Smc5-Smc6 require the Nse5-Nse6 heterodimer, explaining how this nonessential cofactor c

106 ptor, monomers of each receptor compete with heterodimers for space within endocytic structures.

107 We show that HCF244 stability depends on OHP heterodimer formation and introduce the concept of a fun

108 ing heme insertion while preventing inactive heterodimer formation during sGC maturation.

109 , we reported on the early onset of parallel heterodimer formation of the two antimicrobial peptides

110 de additional insight into the regulation of heterodimer formation of tubulin from different biologic

111 onceptual advancement based on blocking PI3K heterodimer formation rather than inhibition of PI3K enz

112 ts supported a hypothesis of PtrCAD1/PtrCCR2 heterodimer formation.

113 of all four cysteines by alanine abolished a heterodimer formation.

114 We determined the crystal structure of the heterodimer formed by human MCT-1 and the N-terminal dom

115 t) and Dachsous (Ds)-and the levels of Ft-Ds heterodimers formed concomitantly.

116 es pathway, which recruited these butenolide heterodimers from a field of 250,000 compounds.

117 ange in concentration and found that tubulin heterodimers from different biological sources differ in

118 ing to the p66 subunit in the mature p66/p51 heterodimer) from a closed to a partially open state upo

119 und Ig (mIg) molecule and the Igalpha/Igbeta heterodimer functioning as antigen binding and signal tr

120 The herpes simplex virus (HSV) heterodimer gE/gI and another membrane protein, US9, whi

121 The Rag GTPase heterodimer has a unique architecture that consists of t

122 ally associated with only one Igalpha/Igbeta heterodimer has been a puzzle.

123 Strikingly, the mGluR2/7 heterodimer has high affinity and efficacy.

124 s main building block, the alphabeta-tubulin heterodimer, has yet to be studied.

125 EDS1-PAD4 heterodimers have a different and broader activity in ba

126 e homodimers that function as conformational heterodimers having allosteric (Eallo) and catalytic (Ec

127 is increased, this assembly dissociates into heterodimers (holo alphabeta forms) before ultimately fo

128 Heterodimers, i.e., CssBA and CssAB, were sufficient to

129 that bind to the IL-2 receptor betagamma(c) heterodimer (IL-2Rbetagamma(c)) but have no binding site

130 on requires the Toll-like receptor (TLR) 2/1 heterodimer in cooperation with Dectin-1 to initiate sig

131 scribe a role for the ZIKV protease NS2B-NS3 heterodimer in mediating neurotoxicity through cleavage

132 D3 complex comprises a diverse alphabeta TCR heterodimer in noncovalent association with three invari

133 osomal localization is blocked by active Rag heterodimer in response to amino acid stimulation.

134 paB pathway but complexes with the NF-kappaB heterodimer in the nucleus for transcriptional activatio

135 fluence enzyme processivity of the Pmt1-Pmt2 heterodimer in vivo.

136 (B) is unique in its function as an obligate heterodimer in which agonist binding and G-protein activ

137 ubunit asymmetry found in the mature p66/p51 heterodimer in which catalytic activity resides in the p

138 bicistronic expression, we obtain an IRSp53 heterodimer in which only one subunit is phosphorylated,

139 terms these promote the formation of kinase heterodimers in a context dependent fashion.

140 ding Ror2 homodimers, Ror2/Fzd7 and Ror2/dsh heterodimers in an endocytosis dependent manner.

141 These adhesins include integrin alphabeta heterodimers in metazoans and single subunit transmembra

142 a cleft created by two adjacent CHIKV E2-E1 heterodimers in one trimeric spike and engaging a neighb

143 s photometry to observe tubulin monomers and heterodimers in solution simultaneously, thereby quantif

144 lated form of URI that is capable of forming heterodimers in vivo.

145 units IL-27p28 and EBi3, and while the IL-27 heterodimer influences T cell activities, there is evide

146 Our simulations further show that the heterodimers interact via salt bridges and hydrophobic f

147 n skeletal muscle fibers, the ATF4-C/EBPbeta heterodimer interacts with a previously unrecognized and

148 stricted geometry of interactions across the heterodimer interface (primarily at the heptad a and d p

149 We also identify a previously unknown heterodimer interface between transmembrane helices 3 an

150 , our results demonstrate that the Okp1/Ame1 heterodimer is a reader module for posttranslational mod

151 When the U2AF heterodimer is bound to a strong, uridine-rich splice si

152 -bound forms and an active form in which the heterodimer is bound to an agonist and a positive allost

153 The nsp16/nsp10 heterodimer is captured in the act of 2'-O methylation o

154 d that a [4Fe-4S](2+) cluster-bound ISCA1a/2 heterodimer is effective in transferring [4Fe-4S](2+) cl

155 The MHC-class-I-like protein of the FcRn heterodimer is encoded by FCGRT.

156 While CD8alphabeta heterodimer is expressed exclusively on CD8(+) T cells,

157 ing that the human adult beta-cell MAFA/MAFB heterodimer is functionally equivalent to the mouse MafA

158 n conditions demonstrated that the Flv1/Flv3 heterodimer is solely responsible for an efficient stead

159 The alphabeta-tubulin heterodimer is the fundamental building block of microtu

160 The nucleotide state of Rag heterodimers is critical for their association with mTOR

161 Formation of Oct4/Sox2 heterodimers is essential for pluripotency establishment

162 MutLgamma (MLH1-MLH3 heterodimer) is a poorly understood member of the eukary

163 res the formation of NF-kappaB family member heterodimers, is regulated by activation receptors, kina

164 For the PE/PPE heterodimers, it has been shown that they interact with

165 of constitutive and HRG-induced ErbB3/ErbB2 heterodimers, it only slightly blocked ErbB3 homodimeriz

166 We used fluorescent heterodimers labeled with enhanced green fluorescent pro

167 the dimer interface of the BRAF(D594G):CRAF heterodimer may represent a promising target in the desi

168 lope glycoprotein (Env) trimer of gp120-gp41 heterodimers mediates virus entry into CD4-positive (CD4

169 In this study, we identify the TPX2/Aurora A heterodimer, nominally considered a mitotic kinase compl

170 mplex is composed of a diverse alphabeta TCR heterodimer noncovalently associated with the invariant

171 We found that the TLR2/6 heterodimer, not TLR2/1, is responsible for CDT recognit

172 In this process, metallic heterodimer NPs were used as catalysts for NW growth to

173 The formation of Myc/Max and Omomyc/Max heterodimers occurs cotranslationally; Myc, Max, and Omo

174 the high-resolution X-ray structures of the heterodimer of Gc and the Gn head and of the homotetrame

175 impeded the nuclear import of NP and PA-PB1 heterodimer of IAV, thereby suppressing the vRNP assembl

176 It is a heterodimer of KIF3A and KIF3C motor polypeptides which

177 repair (MMR) factors, including MutLgamma, a heterodimer of MLH1/MLH3, one of the three MutL complexe

178 ously solved ESX-5 heterotrimers, the PE-PPE heterodimer of our ESX-3 heterotrimer is interacting wit

179 y the beta and common gamma (gamma(c)) chain heterodimer of the IL-2 receptor through trans-presentat

180 regulates abundance of the gp91phox-p22phox heterodimer of the phagocyte NADPH oxidase in human cell

181 An essential heterodimer of the U2AF1 and U2AF2 pre-mRNA splicing fac

182 entify the PAT complex, an abundant obligate heterodimer of the widely conserved ER-resident membrane

183 The SIFV nucleocapsid is formed by a heterodimer of two homologous proteins and is membrane e

184 ubiquitylates and helps to degrade inactive heterodimers of BTB proteins while sparing functional ho

185 pc105/Spc7) can be bypassed; simply inducing heterodimers of Mps1(Mph1) kinase and Bub1 is sufficient

186 elope containing 80 spikes, each a trimer of heterodimers of the E1 and E2 glycoproteins.

187 Consistently, cells lacking functional Rag heterodimer on the lysosome accumulate Ub-Rheb, and bloc

188 actions, but instead stabilizes FANCI:FANCD2 heterodimers on dsDNA.

189 structures of the human full-length GB1-GB2 heterodimer: one structure of its inactive apo state, tw

190 of two peptides that comprise a coiled-coil heterodimer pair with unique DNA handles in order to lin

191 pper, and we show that the WT chain in WT-RQ heterodimers partly reduces basal activity of the RQ cha

192 The nuclear receptor small heterodimer partner (Shp) plays a complex role in lipid

193 cascade involving FXR and FXR-induced small heterodimer partner (SHP) regulates expression of miR-80

194 rtant for the regulation of BA levels, small heterodimer partner (SHP), and bile salt export pump (BS

195 w that FGF15/19 and FGF15/19-activated Small Heterodimer Partner (SHP/NR0B2) have a role in transcrip

196 alters farnesoid X receptor (FXR) and small heterodimer partner gene expression but also inhibits bi

197 The orphan nuclear receptor SHP (small heterodimer partner) is a well-known transcriptional cor

198 f well-known FXR target genes, hepatic small heterodimer partner, and ileal fibroblast growth factor

199 upregulated in C9(+)-derived cells, and its heterodimer partner, LEO1, binds C9(+) repeat chromatin.

200 t activation of TR through activation of its heterodimer partner, the retinoid-X-receptor (RXR), was

201 Simultaneous activation of the heterodimer partners PPARgamma and RXR resulted in high

202 omodimer BmrA from Bacillus subtilis and the heterodimer PatA/PatB from Streptococcus pneumoniae, whe

203 ctive role in the structurally unique pseudo-heterodimer PfCCT protein in a heterologous cellular con

204 n of transcription regulators: the MglA-SspA heterodimer, PigR, and the stress signal, ppGpp.

205 c18-1 binding; binding to syntaxin-1-SNAP-25 heterodimers, precluding SNARE complex formation; and bi

206 ity of cyclase regulation by GCAP1 in RetGC1 heterodimer produced by co-expression of WT and the R838

207 e isolated and characterized a two-component heterodimer protein from the alpha-proteobacterium Methy

208 lso establishes that the engineered covalent heterodimer provides a robust experimental system for in

209 he generality of our biogenetically inspired heterodimer rearrangement was demonstrated in a guided s

210 During amino acid sufficiency, the RAG heterodimer recruits mTORC1 to the lysosomal membrane wh

211 lation of the Toll-like receptor (TLR)1-TLR2 heterodimer (referred to herein as TLR1/2), TLR7 or TLR9

212 n inhibitor of TPX2, the importin-alpha/beta heterodimer, regulates TPX2 condensation in vitro and, c

213 (AtSAG101), but the role of AtEDS1-AtSAG101 heterodimers remains unclear.

214 begins, TFAP2A trades partners, and TFAP2A/B heterodimers reorganize the epigenomic landscape of prog

215 EsxA facilitates dissociation of the EsxA:B heterodimer required for EsxA membrane permeabilization

216 tion of CRY-CRY homo-oligomers and a CRY-BIC heterodimer reveals how the activity of plant CRYs is re

217 eviously showed that mammalian brain tubulin heterodimers reversibly dissociate, following the mass a

218 the molecular mechanism by which the EsxA:B heterodimer separates is not clear.

219 recluded N (alpha)-acetylation inhibited the heterodimer separation and hence prevented EsxA from int

220 The CEH-60:UNC-62 heterodimer serves an unanticipated dual function in int

221 The ability to design orthogonal protein heterodimers should enable sophisticated protein-based c

222 ing, we concluded that cells expressing Sod1 heterodimers showed decreased antioxidant activity, incr

223 in vitro, but it is not known whether these heterodimers signal in vivo.

224 ation that is critical for TLR2/1 and TLR2/6 heterodimer signaling to blunt inflammation in a murine

225 neration and protease activated receptor 1/2 heterodimer signaling.

226 Gene transfer of TCRalphabeta heterodimers specific for clonal neoantigens confirmed c

227 ganisms for a basic physical characteristic: heterodimer stability and monomer exchange between heter

228 ture of a Zip2:Spo16 subcomplex, revealing a heterodimer structurally related to the XPF:ERCC1 endonu

229 Although the VFT heterodimer structure has been resolved(16), the structu

230 EDS1-family evolutionary rate variation and heterodimer structure-guided phenotyping of AtEDS1 varia

231 Three different conformations of A/B heterodimers suggest a mechanism for ATP hydrolysis that

232 peptide-binding pocket 7 (P7) of the HLA-DR heterodimer, suggesting that these alterations might acc

233 The octamer-like fold comprises the heterodimers Taf6-Taf9, Taf10-Spt7 and Taf12-Ada1, and t

234 bispecific antibody using the knob-into-hole heterodimer technology.

235 cient of all ErbB2 molecules and ErbB3/ErbB2 heterodimers than in the mobility of ErbB3.

236 domain architecture and form an antiparallel heterodimer that corresponds to the canonical homodimer

237 We recently engineered a protein heterodimer that dissociates when irradiated with blue l

238 its functional entity comprises an obligate heterodimer that is composed of the GB1 and GB2 subunits

239 We design homotrimers and heterodimers that are stable above pH 6.5 but undergo co

240 in the formation of stimulus-specific NPAS4 heterodimers that exhibit distinct DNA binding patterns.

241 The envelope glycoproteins Gn and Gc form heterodimers that further assemble into tetrameric spike

242 have as allosterically modulated, functional heterodimers, the cyclooxygenases exhibit complex kineti

243 he first is similar to a full-length/Delta10 heterodimer; the second, also sampled by Delta10, is eit

244 ic affinity towards alpha(v)beta(3) integrin heterodimers; the other is linear (RGDSP) and is reporte

245 analyses show that CENP-H and CENP-K form a heterodimer through both N- and C-terminal interactions.

246 gh the action of IL-17A, IL-17F, and IL-17AF heterodimer through their receptors (IL-17RA and IL-17RC

247 gested that GTP binding to one Rag locks the heterodimer to prevent GTP binding to the other.

248 iculum and the binding of the Igalpha/Igbeta heterodimer to the mIg molecule.

249 5) and increased the recruitment of the PI3K heterodimer to the plasma membrane.

250 DNA (ssDNA) overhang recognized by POT1-TPP1 heterodimers to help regulate telomere length homeostasi

251 insulin-stimulated binding of p110-p85alpha heterodimers to IRS1 and activation of PI3K.

252 relationship from binding alpha-beta tubulin heterodimers to the larger proportions of microtubules.

253 rylation-dependent nuclear export of PER-TIM heterodimers to the maintenance of circadian periodicity

254 pe that spans across E1 and E2 and locks the heterodimer together, likely preventing structural rearr

255 In the cumulin heterodimer, two distinct type I receptor interfaces are

256 by the chemical composition of the metallic heterodimer used.

257 armacological properties of the TRESK/TREK-2 heterodimer using a covalently linked TRESK/TREK-2 const

258 MFN2 and MFN1 can form heterodimers via the G interface in a nucleotide-depende

259 NO-binding signal throughout the entire sGC heterodimer, via its coiled-coil domain, to reorient the

260 The heterodimer was also more resistant than homodimers to i

261 based on fusion between SEA and coiled-coil heterodimers was developed that enabled detection of fun

262 Using HLA alpha/beta allelic heterodimers, we bioinformatically predicted immunodomin

263 Correct folding and assembly of the heterodimer were confirmed by the high-resolution (1.88-

264 e cytokines IL-10 and IL-35 (Ebi3-IL-12alpha heterodimer) were divergently expressed by T(reg) cell s

265 suppresses activation of the RAG A/B-RAG C/D heterodimer when amino acids are insufficient.

266 regulates transcription through the p50:p65 heterodimer, where S80 phosphorylation acts in trans to

267 DENR and MCT-1 form a heterodimer, which binds to the ribosome.

268 lexes we showed that the Ame1/Okp1(CENP-U/Q) heterodimer, which forms the COMA complex with Ctf19/Mcm

269 ecombinant EsxA or EsxB protein or the EsxBA heterodimer, which further confirms the role of the EsxB

270 response to nutrients through the Rag GTPase heterodimer, which is regulated by multiple upstream pro

271 he P85-P110 phosphoinositide 3-kinase (PI3K) heterodimer, which reduced PI3K activity and down-regula

272 e the transcription function of the CREB/Meq heterodimer, which targets cellular and viral gene expre

273 ir is monoubiquitination of the FANCD2-FANCI heterodimer, which then recruits nucleases to remove the

274 clear preference for binding curved tubulin heterodimers, which exist in soluble tubulin and at site

275 ons, mammalian cells activate RelA/NF-kappaB heterodimers, which induce genes encoding interferon bet

276 t both nucleotide binding domains of the Rag heterodimer, while the DENN domains interact at the dist

277 ATF4 may promote muscle atrophy by forming a heterodimer with another bZIP family member.

278 While forming a heterodimer with AR-FL to induce nuclear localization of

279 Thus, BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian developme

280 LAT1 forms a disulfide-linked heterodimer with CD98 heavy chain (CD98hc, 4F2hc or SLC3

281 re, we demonstrate that KPAF4 functions as a heterodimer with KPAF5, a protein lacking discernable mo

282 yc is to bind DNA as either a homodimer or a heterodimer with Max that is formed cotranslationally, r

283 We constructed a Grp94 heterodimer with one arm that is catalytically dead, to

284 studies have established that as an obligate heterodimer with retinoid X receptor (RXR), PPARgamma bi

285 es: forming C2A/C2A homodimers, or forming a heterodimer with the zinc finger domain of UNC-10/RIM (C

286 Id1 can prevent E2A from forming heterodimers with bHLH TFs or from forming homodimers.

287 Class I PI3Ks are obligate heterodimers with catalytic and regulatory subunits.

288 e, we found that GGA1t formed homodimers and heterodimers with GGA1.

289 d sphingosine-1-phosphate receptors can form heterodimers with GPCRs from their immediate subfamilies

290 MUR4 forms either a homodimer or heterodimers with its isoforms.

291 We demonstrate that semaphorins can form heterodimers with members of the same semaphorin class.

292 -mediated transcription by replacing MYC/MAX heterodimers with Omomyc/MAX heterodimers.

293 psis thaliana) TNL-mediated immunity, AtEDS1 heterodimers with PHYTOALEXIN DEFICIENT4 (AtPAD4) transc

294 asohibins 1 and 2 (VASH1 and VASH2) can form heterodimers with small vasohibin-binding protein (SVBP)

295 f URI accumulates under Fe deficiency, forms heterodimers with subgroup IVc proteins, and induces tra

296 tivity of AR-V7 and that AR-V7 can also form heterodimers with the full-length AR (AR-FL), there are

297 We have observed that ING5 can form heterodimers with the highly homologous ING4, and that t

298 s to the subfamily II and specifically forms heterodimers with the subfamily III(a + c)1 members, whi

299 nge of quantitatively forming self-assembled heterodimers without other equilibrium by-products is ov

300 ver-expression of the scFv chain to maximize heterodimer yield.