ライフサイエンスコーパス: heterogeneity

1 is limited in its ability to resolve spatial heterogeneity.

2 es carried out without investigating spatial heterogeneity.

3 o each other but still showed some degree of heterogeneity.

4 allenges with sample availability and tissue heterogeneity.

5 challenging due to its spatial and temporal heterogeneity.

6 d is also amenable to clonal analysis of HSC heterogeneity.

7 ods used to harmonize the data and to assess heterogeneity.

8 l fate decisions, inflammation and stem cell heterogeneity.

9 characterized by high genetic and phenotypic heterogeneity.

10 ively low reliability of tasks, and disorder heterogeneity.

11 otactic radiosurgery were excluded to reduce heterogeneity.

12 rties of tumorigenicity, immunogenicity, and heterogeneity.

13 We also assessed between-site heterogeneity.

14 ve dysfunction, likely reflecting biological heterogeneity.

15 ements remains a challenge due to population heterogeneity.

16 ial carcinoma are extreme examples of tumour heterogeneity.

17 esting only partially predicts this clinical heterogeneity.

18 values (n = 110 [48%]) showed high genotypic heterogeneity.

19 isplaying significant genetic and phenotypic heterogeneity.

20 but also contain an adequate degree of image heterogeneity.

21 nsively characterize the underlying cellular heterogeneity.

22 is limited by the considerable between-study heterogeneity.

23 st and parasite factors are involved in this heterogeneity.

24 ells and we observed intra and inter tumoral heterogeneity.

25 ation through bridges maintains this nuclear heterogeneity.

26 to devise a framework for parsing human iNKT heterogeneity.

27 olve systems with a high level of structural heterogeneity.

28 lume correction that accounts for background heterogeneity.

29 ease are a key factor to account for disease heterogeneity.

30 tumors known for their inter- and intratumor heterogeneity.

31 w burst propensity relates to pyramidal cell heterogeneity.

32 enced in detail, especially regarding cancer heterogeneity.

33 pronounced genetic, phenotypic, and clinical heterogeneity.

34 onstrates substantial clinical and molecular heterogeneity.

35 and statistical modeling to grapple with the heterogeneity.

36 by vast inter- and intra-familial phenotypic heterogeneity.

37 olecular targets, consistent with structural heterogeneity.

38 ease with high intratumoral and intertumoral heterogeneity.

39 .58)], but not mucinous [0.99 (0.88-1.10), P-heterogeneity = 0.01] tumors.

40 -F transmission with substantial statistical heterogeneity across studies.

41 cellular composition, which reveals striking heterogeneity across these samples.

42 The heterogeneity among centers was not related to the incid

43 Metabolic heterogeneity among human tumors poses a challenge to de

44 trains, which provides evidence that disease heterogeneity among the synucleinopathies is caused by d

45 ith plot was used to investigate statistical heterogeneity amongst studies.

46 ot recapitulate pathobiology including tumor heterogeneity, an inherent feature of cancer that underl

47 te and tumor size, solid tumors versus tumor heterogeneity and a necrotic phenotype, and optimal sele

48 amplification promotes intratumoral genetic heterogeneity and accelerated tumor evolution(1-3); howe

49 ancer with a thermal camera reveals material heterogeneity and delineates diseased from healthy tissu

50 Similarly, defining metabolic heterogeneity and fuel-switching signals in nonneoplasti

51 mine medullary thymic epithelial cell (mTEC) heterogeneity and its influence on CD1d-restricted iNKT

52 Tumor heterogeneity and lack of knowledge about resistant cell

53 central principle underpinning intra-tumoral heterogeneity and motivates therapeutic targeting of the

54 In light of the metabolic heterogeneity and plasticity of cancer cells that had un

55 cteristics (for example, sample and cellular heterogeneity and platform used) were critical in determ

56 not be easily accounted for by environmental heterogeneity and poses challenging questions for unders

57 atched data and can be confounded by genomic heterogeneity and presence of sub-clonal mutations.

58 es should rectify these potential sources of heterogeneity and reach a consensus regarding the inflam

59 The loss of conformational heterogeneity and related functional diversity emphasize

60 evelopmental disorders because of phenotypic heterogeneity and the absence of large-scale genomic scr

61 In this study, we investigated epicardial heterogeneity and the functional diversity of discrete e

62 The vast molecular heterogeneity and the functional group diversity of this

63 Regions of tumor heterogeneity and the hypoxic microenvironment were obse

64 To understand this heterogeneity and the regulation of flagella quantity, w

65 n is driven by a combination of intersubject heterogeneity and the relatively low reliability of stan

66 over-expressed in cancer and promotes tumour heterogeneity and therapy resistance.

67 and relapse that follows is driven by tumor heterogeneity and therapy-resistant populations that can

68 derstand disease aetiology, progression, and heterogeneity and to target future treatments to a highe

69 Moreover, the experimental heterogeneity and wide-ranging quality of high-throughpu

70 reticuloendothelial system clearance, tumor heterogeneity, and complexity of the tumor microenvironm

71 ation, heightened angiogenesis, intratumoral heterogeneity, and deleterious tumor microenvironmental

72 l single cells, their organization and their heterogeneity, and enabled the cellular architecture of

73 "strong", based on estimate of effect sizes, heterogeneity, and risk of bias.

74 d our understanding and appreciation of LNSC heterogeneity, and the role they play in coordinating im

75 ional significance of putative aging-related heterogeneity are also unknown.

76 cale domains with local structural and polar heterogeneity are formed, by tuning complex chemical com

77 n with regards to biocompatibility and brain heterogeneity are then explored.

78 NA-seq) allows us to dissect transcriptional heterogeneity arising from cellular types, spatio-tempor

79 ma frailty models incorporated the effect of heterogeneity associated with genetic transmission clust

80 hese findings are explained by environmental heterogeneity at coarser grains, and to a far lesser ext

81 ged 1100 nt, but with substantial fine-scale heterogeneity at individual hot spots.

82 Due to significant heterogeneity at the clinical and genetic levels, curren

83 the primary tumour but can exhibit subclonal heterogeneity at the genomic, epigenetic and phenotypic

84 t the underlying mechanisms that govern such heterogeneity at the level of gene expression.

85 omponents whose function relies on molecular heterogeneity at the nanometer scale.

86 nologies enable the study of transcriptional heterogeneity at the resolution of individual cells and

87 ng new framework to better understand cancer heterogeneity based on somatic mutations.

88 vated due to Pitx2 deficiency: 1) Electrical heterogeneity between left and right atria increases; an

89 f simple appendicitis in children, to reduce heterogeneity between studies and facilitate data synthe

90 The chi(2) test was used to study heterogeneity between trials, and the I(2) statistic was

91 d a different strategy to emulate such local heterogeneity by forming nanopillar regions in perovskit

92 in-associated benefits and harms or examined heterogeneity by population subgroups or assumed treatme

93 Just like the nature vs nurture debate, heterogeneity can arise from intrinsic or environmental

94 system functions they catalyze, whether such heterogeneity can be maintained in the face of altered r

95 els combining T2-weighted SI and T2-weighted heterogeneity can differentiate metastases from lipid-po

96 Intratumoral heterogeneity can occur via phenotype transitions, often

97 o integrate current understanding of patient heterogeneity captured under the acronym nonalcoholic fa

98 uencing background noise and potential tumor heterogeneity challenge the ability to confidently call

99 Heterogeneity characterization is crucial to define the

100 support, we argue that three factors-climate heterogeneity, collinearity among climate variables, and

101 ; HR, 1.69 [95% CI, 1.47-1.94]; P values for heterogeneity comparing 18-39 years with 40-59 years and

102 Tumor cell-type heterogeneity, defined as the proportion of the various

103 dial-epicardial dissociation marked temporal heterogeneity, discordant and transitioning wavefronts p

104 Despite their functional heterogeneity, dormant label-retaining (LR) and non-LR h

105 helf variability in salinity to permeability heterogeneity due to permeable conduits and normal fault

106 The purpose of this study was to define CF heterogeneity during ventricular remodeling and the unde

107 nal view of normal Hu-MuSCs and describe new heterogeneity, enabling separation of functionally disti

108 hin these discrete types, we find continuous heterogeneity encoding spatial gradients of gene express

109 ysed across three sites of PHENOM (Psychosis Heterogeneity Evaluated via Dimensional Neuroimaging) co

110 istance and provide genomic evidence for the heterogeneity frequently observed in clinical settings.

111 ration (scAI) method to deconvolute cellular heterogeneity from parallel transcriptomic and epigenomi

112 ative and quantitative description of global heterogeneity (GH) and DH for samples and blending proce

113 responsible for drug activation, but genetic heterogeneity has hindered development of a molecular di

114 The basis of this disease heterogeneity has proved difficult to resolve due to poo

115 Size heterogeneity has traditionally imposed large challenges

116 e, the pathways and networks that sustain EC heterogeneity have not been fully delineated.

117 l, studies in the lung displayed significant heterogeneity (I(2) 98%, P < .0001), but no significant

118 Meta-analysis revealed moderate heterogeneity (I(2) = 62%).

119 tigate the role of pre-existing lithospheric heterogeneities in continental microplate rotation.

120 ysis can characterize intratumour phenotypic heterogeneity in a disease-relevant manner, with the pot

121 doption of diagnostic scintigraphy, there is heterogeneity in adherence to consensus guidelines.

122 alysis of included studies identified marked heterogeneity in animal models of donor brain death coup

123 Intratumoral heterogeneity in bladder cancer is a barrier to accurate

124 nsional flow cytometry to reveal substantial heterogeneity in both effector and immature populations.

125 ether the duration of obesity was related to heterogeneity in cardiometabolic risk.

126 ity, and adaptive capacity all contribute to heterogeneity in climate change vulnerability, predictin

127 atical models that properly account for risk heterogeneity in communities approaching elimination, wh

128 hypersensitivity demonstrated a significant heterogeneity in current practice, suggesting the need t

129 in clinical care and reduces methodological heterogeneity in defining phenotype, obscuring biologica

130 nvestigate the role played by conformational heterogeneity in determining the activity of the C-termi

131 lation globally however there is significant heterogeneity in existing epidemiological studies.

132 ore previously undescribed spatial metabolic heterogeneity in GBM biology and opportunities for MSI i

133 nanosecond-timescale dynamics and structural heterogeneity in GCK using a combination of unnatural am

134 approaches developed for T2D to the study of heterogeneity in GDM.

135 Results (2)H MR spectroscopic imaging showed heterogeneity in glycolytic flux across the tumor and an

136 roimaging datasets can be used to understand heterogeneity in human brain development.

137 Modeling tools that can capture heterogeneity in infectiousness and contact are importan

138 re studies to account for cell cycle-related heterogeneity in iPSCs.

139 break this trade-off by evolving phenotypic heterogeneity in lag time.

140 The heterogeneity in meta-analyses is usually assumed to fol

141 Canada, we present the spatial and temporal heterogeneity in pathogen prevalence and intensity of in

142 yond group-level estimates to illustrate the heterogeneity in patterns of brain development.

143 Regional heterogeneity in phenotype trends indicates complex resp

144 However, it remains unknown whether heterogeneity in phosphorylation of key structural prote

145 or the phylogeny contrasts with high genomic heterogeneity in phylogenetic signal and introgression.

146 We report neuroanatomical heterogeneity in populations of the serotonergic raphe n

147 veillance strategies, leading to significant heterogeneity in practices.

148 There is no evidence of heterogeneity in PRS performance in Chinese, Malay and I

149 patterns of innervation of target areas and heterogeneity in receptor distributions, suggests that a

150 in defining phenotype, obscuring biological heterogeneity in research concerning allergy, asthma, an

151 ze trait responses to environment, revealing heterogeneity in response to anthropogenic change.

152 Disentangling psychopathological heterogeneity in schizophrenia is challenging, and previ

153 Neurobiological heterogeneity in schizophrenia is poorly understood and

154 Given the heterogeneity in symptoms, the detection of clinical tra

155 Perspective, we describe efforts to decipher heterogeneity in T2D and detail how we and others are ap

156 Here we find ESCs exhibit intrinsic heterogeneity in the absence of external gradients by fo

157 We analyze heterogeneity in the association by wealth quintiles and

158 ed to interact with FcRn with a considerable heterogeneity in the binding affinity.

159 Our results suggest that heterogeneity in the cellular and molecular features of

160 Finally, the results show considerable heterogeneity in the effect of age structure and human c

161 evelop a multi-trait pleiotropy model of the heterogeneity in the exposure-outcome analysis due to pa

162 ransition from mitosis to meiosis results in heterogeneity in the female germ cell populations, which

163 Tumors harbor extensive genetic heterogeneity in the form of distinct clone genotypes th

164 These results indicate U heterogeneity in the fuel pellet from incomplete blendin

165 efficiency of individual lines, and utilise heterogeneity in the genetic background across individua

166 We found striking patient-to-patient heterogeneity in the hyperphosphorylated species of solu

167 ng, which likely contribute to myofibroblast heterogeneity in the infarcted myocardium.

168 Our results suggest that the heterogeneity in the interaction pattern will play an im

169 tropy (S(conf)), we find clear signatures of heterogeneity in the monomeric conformational entropies.

170 However, electron microscopy showed heterogeneity in the particles and a total of 13 unique

171 However, there is considerable heterogeneity in the tools used to measure frailty.

172 We found that cellular heterogeneity in the TRN is characterized by a transcrip

173 The vast heterogeneity in the types of airborne samples collected

174 ession and response to therapy, highlighting heterogeneity in the underlying biological mechanisms.

175 ssionals and researchers (n = 448), we found heterogeneity in the way REA are perceived, defined, and

176 There was heterogeneity in these associations across countries.

177 nic mechanisms, and the basis for phenotypic heterogeneity in this disorder, remain unknown.

178 al that models encompass both spatiotemporal heterogeneity in transmission and movement.

179 -of-the-art dose prediction algorithms using heterogeneity index, conformity index, and various dosim

180 rch into two potential sources of behavioral heterogeneity: individual differences in decision-making

181 1) open the lung to minimize the presence of heterogeneity-induced stress concentrators that are focu

182 Here we explore how different layers of heterogeneity influence type 2 immunity.

183 nomeric disulfides triggers marked dynamical heterogeneity, interfacial wettability, and asymmetric s

184 Intratumoral heterogeneity is a common feature of many myeloid leukem

185 This heterogeneity is believed to play a previously unknown r

186 Another relevant aspect in intratumor heterogeneity is cell plasticity-the ability of a cell t

187 bestrophin channels, significant phenotypic heterogeneity is evident.

188 Furthermore, heterogeneity is further elevated due to Pitx2 deficienc

189 ral phenomena, this conceptual ambiguity and heterogeneity is hardly surprising.

190 coinfection, plasma immune activation marker heterogeneity is in part attributable to age, sex, cirrh

191 This microsite heterogeneity is often invoked to explain non-normal dis

192 Although heterogeneity is recognized within the murine satellite

193 lex human health conditions with etiological heterogeneity like Autism Spectrum Disorder (ASD) often

194 This heterogeneity may be explained by genetic variation with

195 e, where pulmonary perfusion is passive, and heterogeneity may be increased because of the underlying

196 MOL heterogeneity might correlate with the local environment

197 curacy of tumor detection, interrogate tumor heterogeneity, monitor treatment response, focus surgica

198 urvival under stress and fosters non-genetic heterogeneity (NGH).

199 tometry (MP) can accurately characterize the heterogeneity of a sample using minimal material with hi

200 LS and bvFTD and shed light on the cognitive heterogeneity of ALS, expanding its possible neuropsycho

201 informative plots to visualise cell-to-cell heterogeneity of alternative splicing profiles across si

202 Recent findings reveal functional heterogeneity of AMs.

203 ring Plasmodium infection and highlights the heterogeneity of antigen-presenting cells involved in CD

204 rganisms, and in the second, we show how the heterogeneity of autism mechanisms in humans can be brok

205 Given the great heterogeneity of cell types located in the PVH, we perfo

206 tion of tau and TDP-43 pathology, and to the heterogeneity of clinical disease.

207 Emerging data point to functional heterogeneity of fibroblasts.

208 cells migrate in human GC and highlight the heterogeneity of GC for Tfh cell motility.

209 Here, we set out to understand the heterogeneity of HbF activation by developing techniques

210 malignancies; however, spatial and temporal heterogeneity of HER2 expression may prevent identificat

211 Despite the heterogeneity of IBS, patients have significant differen

212 intercancer, interpatient, and intratumoral heterogeneity of interacting immune checkpoints.

213 ese data, capturing the spatial and temporal heterogeneity of intralesional drug PK, have major impli

214 ctices, which drive the spatial and temporal heterogeneity of life cycle environmental impacts.

215 y, 10 patients (53%) had granular pattern or heterogeneity of liver.

216 erse decisions and highlights the biological heterogeneity of loss aversion across individuals.

217 The intertumoral and intratumoral heterogeneity of lung cancers as well as incidences of s

218 y, leading to transcriptional and epigenetic heterogeneity of macrophages in atherosclerotic plaques.

219 gnificant changes in ecosystem-level spatial heterogeneity of microbial functions and communities.

220 ement microbiome', we ranked by priority the heterogeneity of modern husbandry practices/perceptions

221 We also identify considerable heterogeneity of movement, including spring/summer accel

222 fically associated with the genetic variance heterogeneity of oil concentration, 89% can be explained

223 ne likely contributing factor is the genetic heterogeneity of patients that might modify their vulner

224 These observations revealed a marked heterogeneity of release site properties within individu

225 Widespread heterogeneity of results from studies published to date

226 ethod, the LGE-dispersion mapping, to assess heterogeneity of scar, and evaluated its prognostic role

227 Brassicaceae present a great heterogeneity of seed oil and fatty acid composition, ac

228 Unfortunately, the heterogeneity of sepsis at the individual patient level

229 med in adults, little is known regarding the heterogeneity of severe asthma in children, particularly

230 07 donors revealed an unprecedented level of heterogeneity of SLC5A2 expression.

231 derstanding of the phenotypic and functional heterogeneity of stromal cells in tumors.

232 Our results illustrate the heterogeneity of T cell responses, furthering our unders

233 and specificity, we were able to confirm the heterogeneity of the brain Li distribution and its inter

234 atments for autism spectrum disorders is the heterogeneity of the condition.

235 tandard IR spectromicroscopy, AFMIR revealed heterogeneity of the deposits and established that vanco

236 The tissue-specific heterogeneity of the endothelium is maintained during sy

237 Given the structural and functional heterogeneity of the hippocampal formation, we sought to

238 dels that reflect the genomic and biological heterogeneity of the human disease.

239 Both intertumoral and intratumoral heterogeneity of the hyperpolarized pyruvate and lactate

240 test and I(2) index were used to assess the heterogeneity of the studies.

241 In metastatic cancer, the degree of heterogeneity of the tumor microenvironment (TME) and it

242 n reduces microvessel turnover and decreases heterogeneity of the tumor microenvironment, hence PI3Kb

243 between fast growing tumors and the size and heterogeneity of their nuclei.

244 emphasis is placed on new insights into the heterogeneity of these cells as determined by lineage tr

245 To characterize the genetic and molecular heterogeneity of these tumors, we studied 31 diffuse LBC

246 Heterogeneity of treatment effect (HTE) refers to the no

247 , rehospitalizations, and expenditures), and heterogeneity of treatment effect.

248 ns in lymphomas have uncovered a significant heterogeneity of tumor-infiltrating slan(+) -cells, incl

249 understanding the mechanisms underlying the heterogeneity of type 2 immune responses between individ

250 aining at geniculate level could reflect the heterogeneity of Y cell subpopulations and the heterochr

251 research into the influence of the collector heterogeneity on the nano-ZVI mobility.

252 er, do not comprehensively evaluate blastema heterogeneity or address lineage restriction of closely

253 ed with caution in the presence of substrate heterogeneity or variable sample thickness.

254 without CAD (OR 1.01; 95% CI 0.99, 1.03) and heterogeneity P = 0.0041.

255 alterations, mutation signatures, intratumor heterogeneity, pathway alterations, histology, and overa

256 Different heterogeneity pattern were realized by printing separate

257 n (EMT) has been associated with cancer cell heterogeneity, plasticity, and metastasis.

258 However, tumor heterogeneity presents a significant technical challenge

259 The resulting sediment geochemical heterogeneity provides a critical control on the release

260 We show that individual heterogeneity provides a key intermediary mechanism with

261 arcoma samples, we show that DNA methylation heterogeneity provides information complementary to the

262 traepithelial carcinoma (STIC), with genetic heterogeneity providing a platform for HGSC evolution.

263 chemical mechanisms that govern this spatial heterogeneity remain largely unknown.

264 but the functional-anatomical basis of this heterogeneity remains poorly understood.

265 This phenotypic heterogeneity requires the production of the nucleotides

266 Dissecting white adipose tissue heterogeneity revealed that the MCT1 is expressed in ind

267 Early cultures maintain the clonal heterogeneity seen in PDAC with similar phenotypes (cyst

268 oss HF science, interpreting and handling of heterogeneity should be standardized.

269 trongly shaped by population aggregation and heterogeneity, such that epidemics in crowded cities are

270 ies (n=5936 patients), was 4.62% (2.25-7.65; heterogeneity test Q=527.33; tau(2)=0.0384; I(2)=95.05%;

271 baseline signaling profiles and far greater heterogeneity than previously described.

272 Furthermore, we discuss multiple aspects of heterogeneity that both contribute to and result from th

273 leading cause of cancer mortality, exhibits heterogeneity that enables adaptability, limits therapeu

274 ritical biological insight into the cellular heterogeneity that is masked by bulk-scale analysis.

275 ional level (i.e. intersections exhibit high heterogeneity), the average differences are potentially

276 and improved our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, a

277 cancer-immune interaction sculpts intratumor heterogeneity through the selection of immune-evasive cl

278 eviations from helicity and other sources of heterogeneity to be quantified and corrected for at the

279 There is significant heterogeneity to this progression of glycemia after onse

280 ns of our data sets, preserving the chemical heterogeneity uncovered by the single-cell analysis whil

281 This heterogeneity was explored in different additional meta-

282 Heterogeneity was moderate (I(2)=51%).

283 ing an essential component of meta-analyses, heterogeneity was not reported for nearly 30% of outcome

284 Heterogeneity was performed adjusting multilevel models.

285 To clarify the impact of such heterogeneity, we investigated spatiotemporal variation

286 re conducted for 10 variables; the tests for heterogeneity were not statistically significant for any

287 ility, rainfall seasonality, and topographic heterogeneity were the strongest predictors of taxonomic

288 tuberculosis presents with notable clinical heterogeneity, which complicates diagnosis, treatment, a

289 s complicated on account of the vast genetic heterogeneity with >75 candidate disease-associated gene

290 ould be used to accommodate inter-individual heterogeneity with either approach.

291 We find that it displays conformational heterogeneity with various elliptical shapes, and with s

292 ghly similar polymer chemistries or identify heterogeneities within individual polymer spots.

293 2D measurements consider heterogeneity within a single observable section but not

294 is undisputed, the level of mesenchymal cell heterogeneity within and between organs, while appreciat

295 Although studies have proposed lineage heterogeneity within GMPs, it is unclear if committed pr

296 We examined mutational heterogeneity within individual patients with melanoma u

297 These findings point to previously unknown heterogeneity within the bone marrow microenvironment, i

298 We report an unexpected heterogeneity within the naive T cell compartment in mic

299 Despite the heterogeneity within the two groups of wines, it was pos

300 a noninvasive means of dissecting biological heterogeneity, yet its sensitivity, specificity, and val