ライフサイエンスコーパス: heterogenous

1 lly uniform populations to be phenotypically heterogenous.

2 neuronal alterations may be mechanistically heterogenous.

3 the population of circular T-DNAs was highly heterogenous.

4 Most human tumors are highly heterogenous.

5 gkin lymphoma, is clinically and genetically heterogenous.

6 ones are morphologically and physiologically heterogenous.

7 ent asthma are poorly understood, but likely heterogenous.

8 related to depressive symptoms may be highly heterogenous.

9 tients with clonal cytogenetic patterns were heterogenous; a variety of karyotypic defects with numer

10 95.2% against MOG-ab NMOSD and 87.5% in the heterogenous ab-negative NMOSD cohort.

11 n between the noncollider and the outcome is heterogenous across levels of the exposure.

12 lling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in a

13 ent human cells in culture showed robust and heterogenous activation of six genes in the type I IFN p

14 It relies on the assembly of heterogenous, active and passive Cosserat rods into dyna

15 We found that MerTK expression is heterogenous among macrophage subsets, being mostly rest

16 The definition of RVF as an outcome was heterogenous among models.

17 Bile acids (BAs) comprise heterogenous amphipathic cholesterol-derived molecules t

18 asure bone mineral density; and inclusion of heterogenous and changing thyroid disease states.

19 on kidney transplant outcomes have reported heterogenous and conflicting results.

20 ls in tissues, which is CD103(-)CD11b(+), is heterogenous and depends on both Flt3 and MCSF-R.

21 The cellular membrane is very heterogenous and enriched with high-density regions form

22 Atopic dermatitis (AD) is a heterogenous and highly complex disease characterized by

23 ion patterns within the mTEC compartment are heterogenous and include multiple differentiated cell st

24 s balance becomes perturbed are likely to be heterogenous and may involve host immune factors, viral

25 es have recently reported that CAFs are more heterogenous and plastic than was previously thought.

26 Fanconi Anemia (FA) clinical phenotypes are heterogenous and rely on a mutation in one of the 22 FAN

27 oscale IR spectroscopy and imaging on highly heterogenous and rough paint thin sections.

28 Tendon cells are heterogenous and sparsely distributed in a dense collage

29 . cydno and H. melpomene is high but broadly heterogenous, and admixture is reduced at the preference

30 Overall, the Medalist cohort was highly heterogenous, and genetic testing suggested that several

31 s with reduced ejection fraction (HFREF) are heterogenous, and our ability to identify patients likel

32 rtheless, individual response to CCT remains heterogenous, and the predictive potential of neuroimagi

33 als were men (56%), their race/ethnicity was heterogenous, and they were referred from a variety of s

34 tion and mortality to compare geographically heterogenous areas.

35 ied cutins showed that the polymerization is heterogenous at the fruit surface.

36 urg Micro syndrome and Martsolf syndrome are heterogenous autosomal-recessive developmental disorders

37 ed on the plasma membrane of morphologically heterogenous axon terminals contacting unlabeled as well

38 m2, 63% were small axons and morphologically heterogenous axon terminals, 31% of which apposed Dyn-la

39 such fluctuating environments, a dynamically heterogenous bacterial population can sometimes achieve

40 ions that occur between liposomes and detect heterogenous behavior in these reactions.

41 ding exposure to FVIII concentrates, but the heterogenous biological response to desmopressin, showin

42 on for deconvoluting the cellular mixture of heterogenous biospecimens offer a promising solution, ho

43 The responding human CD8+ T cells showed a heterogenous but limited TCR Vbeta gene usage.

44 SSTs are spatially heterogenous, but generally support late Oligocene warmi

45 For all cell types, cluster formation is heterogenous, but is regulated so that cluster size and

46 action of Darwinian selection on genetically heterogenous cancer cell populations.

47 Highly heterogenous cancers, such as triple-negative breast can

48 ith both oxides and metals are essential for heterogenous catalysis, leading to remarkable synergisti

49 IF-8 with isolated Au25 sites is a promising heterogenous catalyst with size selectivity imparted by

50 o high-efficiency energy input and effective heterogenous catalytic conversion in ECR systems are com

51 ppIAPP, GFAP, and IGRP as CTL epitopes for a heterogenous CD8(+) T-cell response in type 1 subjects a

52 Heterogenous cell fusion experiments demonstrated that t

53 PINC probably are a heterogenous cell population that can be specified for u

54 The mice developed tumors composed of a heterogenous cell population that resembled that seen in

55 gle-cell RNA sequencing (scRNA-seq) resolves heterogenous cell populations in tissues and helps to re

56 reversible control of gene expression across heterogenous cell populations via fluorescence-based qua

57 e rare Reed-Sternberg cell, concealed in its heterogenous cellular context, also provides a formidabl

58 In hippocampus, there were heterogenous changes in the number of interneurons while

59 fspring of mothers with NLRP5 mutations have heterogenous clinical and epigenetic features, but cases

60 ecause of a lack of frameworks for analyzing heterogenous clinical data.

61 tion rates in characteristic but genetically heterogenous clinical phenotypes, such as a Stargardt-li

62 most common microdeletion in humans, with a heterogenous clinical presentation including medical, be

63 In a large heterogenous cohort of critically ill patients, low admi

64 Thus, BLA excitatory neurons are a highly heterogenous collection of neurons that spatially covary

65 The liver comprises different, heterogenous compartments; stromal cells within those co

66 Otosclerosis is a relatively common heterogenous condition, characterized by abnormal bone r

67 Variant syndromes are heterogenous conditions that probably reflect referral b

68 xistence persisted under both homogenous and heterogenous conditions.

69 nventional drug conjugation strategies yield heterogenous conjugates with relatively narrow therapeut

70 epresent social diversity, in homogeneous or heterogenous contexts.

71 maintaining cellular heterogeneity during a heterogenous culture.

72 geneous/sorted subpopulations giving rise to heterogenous cultures that represented the entire hierar

73 Heterogenous data about the prognostic impact of atrial

74 Our results show that models trained on heterogenous data types and diverse truth resources gene

75 nd knocks down endogenous gene expression in heterogenous DC subsets, (monocyte-derived DCs [MDDCs],

76 Endothelial cells (ECs) are widely heterogenous depending on tissue and vascular localizati

77 The methods used to detect these heterogenous differences in tumor samples are critical,

78 Prostate cancer (PC) is a highly heterogenous disease and one of the leading causes of mo

79 Complex diseases with highly heterogenous disease progression among patient populatio

80 Atopic dermatitis (AD) is a multifactorial, heterogenous disease that arises as a result of the inte

81 Chronic lymphocytic leukemia (CLL) is a heterogenous disease that is highly dependent on a cross

82 rmansky-Pudlak syndrome (HPS), a genetically heterogenous disease with misregulation of the biogenesi

83 Non-small-cell lung cancer is a heterogenous disease, with multiple different oncogenic

84 e cause and pathogenesis of this complex and heterogenous disease.

85 st severe manifestations of this genetically heterogenous disease.

86 alidation methods and difficulty in studying heterogenous diseases of aging.

87 Whereas scleroderma is a heterogenous disorder in terms of disease symptoms and c

88 ature Ovarian Failure (POF) is a genetically heterogenous disorder that leads to hypergonadotropic ov

89 ecombination and somatic hypermutation, is a heterogenous disorder with at least 5 distinct molecular

90 by allowing stratification of what remains a heterogenous disorder.

91 yndromes are a group of rare and genetically heterogenous disorders resulting from defects in the str

92 violation, implying that any application to heterogenous disorders such as autism spectrum disorder

93 ron microscopy suggest that galectin-3 forms heterogenous, disorganized cross-linking complexes with

94 is robustly induced by an environment with a heterogenous distribution of extracellular and intracell

95 The heterogenous distribution of MORs within individual RVL

96 We report a heterogenous distribution of neurotransmitter receptor b

97 ic images of caseous calcification are often heterogenous due to calcium and lipid deposits, and the

98 Further, we identify the heterogenous dynamics of model coarse-grained polymer ch

99 Many amorphous materials show spatially heterogenous dynamics, as different regions of the same

100 stic fibrosis (CF) reveal the importance and heterogenous effects of the position of the premature te

101 ions, E60X-, G542X- and W1282X-CFTR revealed heterogenous effects of these PTCs on CFTR function.

102 were unable to completely treat tumors with heterogenous EGFRvIII expression, leading to outgrowth o

103 Second, S1PR1 signaling in the heterogenous endothelial cell (EC) subtypes occurs at sp

104 Irregular margin and heterogenous enhancement in DCE-MRI were associated with

105 typic characteristics were evaluated in this heterogenous environment.

106 inical K. pneumoniae isolates are remarkably heterogenous, even within clusters or individual patient

107 lung cancers (NSCLCs), are characterized by heterogenous expression of p53 protein in the neoplastic

108 microenvironment conditions (e.g., hypoxia, heterogenous extracellular matrix) exert a dramatic sele

109 Seizures are heterogenous; extrainsular propagation occurs early, acc

110 Ultrasonographic (size, depth, vascularity, heterogenous features, septae) and MRI (size, depth, vas

111 , septae) and MRI (size, depth, vascularity, heterogenous features, septae, complete fat signal suppr

112 It assembles heterogenous, filamentous, enveloped virus particles con

113 antioxidants, calling for further studies in heterogenous food products.

114 risons, dosage, and outcome measurement were heterogenous for head-to-head comparisons.

115 ovides smooth velocity fields even in highly heterogenous formations with discrete fractures.

116 oietic progenitors characterized by acquired heterogenous genetic changes that alter normal mechanism

117 Fanconi anemia (FA) is a heterogenous genetic disease with a high risk of cancer.

118 talyze the reduction of soluble fumarate and heterogenous graphene oxide, with electrons from an exte

119 routine electrocardiogram recordings from a heterogenous group of 70 adult ICU patients.

120 Costimulatory molecules are a heterogenous group of cell surface molecules that act to

121 GABAergic interneurons represent a heterogenous group of cell types in neocortex that can b

122 erneurons in the cerebral cortex represent a heterogenous group of cells that generate the inhibitory

123 The white-dot syndromes are a heterogenous group of chorioretinal disorders that have

124 l and diffuse lung disease (chILD) is a rare heterogenous group of conditions, with symptoms often ov

125 The Ehlers-Danlos syndromes are a heterogenous group of diseases that cause connective tis

126 Syndrome X and microvascular angina are a heterogenous group of diseases.

127 time it has become apparent that these are a heterogenous group of disorders which, while sharing som

128 Retinitis pigmentosa (RP) is a genetically heterogenous group of eye diseases in which initial dege

129 tions for systematic and regimented use by a heterogenous group of health care providers.

130 Cutaneous T cell lymphomas (CTCLs) are a heterogenous group of lymphoproliferative disorders caus

131 nes health conditions encountered in a large heterogenous group of migrants.

132 nsic properties that allow permeation of the heterogenous group of molecules acting as organic osmoly

133 The restrictive cardiomyopathies are a heterogenous group of myocardial diseases that vary acco

134 tau gene mutations that are pathogenic for a heterogenous group of neurodegenerative disorders, calle

135 tes, in patients with neuroacanthocytosis, a heterogenous group of neurodegenerative hereditary disor

136 Cutaneous T-cell lymphomas (CTCLs) are a heterogenous group of non-Hodgkin's lymphomas characteri

137 lindness and is a clinically and genetically heterogenous group of optic neuropathies.

138 Long noncoding RNAs (lncRNAs) are a heterogenous group of RNAs, which can encode small prote

139 lity will be universally effective against a heterogenous GSC population.

140 marsupials, and thus occupied seasonally dry heterogenous habitats long before the onset of late Neog

141 This method allowed us to observe heterogenous host sequences incorporated into IAV mRNA,

142 al cell-based therapy exhibiting efficacy in heterogenous immune-mediated diseases such as cutaneous

143 ufficiency (CTLA4h) lead to a phenotypically heterogenous, immune-mediated disease that can include n

144 ageal or columnar duodenal epithelia and was heterogenous in different regions of the BE surface.

145 ncing revealed that the Kras(mut) allele was heterogenous in primary tumors yet homogenous in metasta

146 ell types, including neurons, and are highly heterogenous in size and composition.

147 embrane rafts are spatially and functionally heterogenous in the cell membrane.

148 r, neurons with high modulation indexes were heterogenous in the spatial organization of ON and OFF r

149 tially confined to the lung interstitium and heterogenous in their expression of CD11c, MHC class II,

150 umors are often polyclonal and are therefore heterogenous in their genomic and molecular profiles, wh

151 and around Kathmandu, we measured a high but heterogenous incidence of typhoid.

152 nterpretability or interpreting results with heterogenous information which may confuse users; (ii) i

153 Surfactant deactivation causes a heterogenous injury, with all three alveolar types prese

154 es, offers an efficient, robust and low-cost heterogenous integration capability of large-size device

155 It causes heterogenous intratumoral distribution of drugs and macr

156 of PSI, yet the SMA-PSI complexes display a heterogenous kinetic behavior.

157 A dramatic, heterogenous landscape of molecular species was revealed

158 of pollen collected by honey bee colonies in heterogenous landscapes and in many hand-collected polle

159 LCEs are constructed in both monolithic and heterogenous layouts that exhibit complex shape changes,

160 binomannan (LAM) is a high molecular weight, heterogenous lipoglycan present in abundant quantities i

161 Tween caused a heterogenous lung injury with areas of normal alveolar m

162 hypothyroid mice contained fewer beta-cells, heterogenous MAFA expression, and increased glucagon(+)

163 A version with typical heterogenous mammalian glycoforms (ED(50) = 11 mug) had

164 Simple models of signal propagation in heterogenous media, such as percolation theory, can pote

165 fat increased gel strength but led to a more heterogenous microstructure, which may be improved by ho

166 ered a single ethnic group, they represent a heterogenous mixture of ancestries who can self-identify

167 ll size bioparticles (i.e., exosomes) from a heterogenous mixture through negative depletion and prov

168 ced the elastase release from homogenous and heterogenous mixtures of neutrophils and monocytes.

169 contrast, abundant, more highly sulfated and heterogenous mixtures of octasaccharides with lower affi

170 All strands formed heterogenous mixtures of structures, with features of qu

171 Surprisingly, the effect of resolvin D1 on heterogenous mixtures was antisynergistic, resulting in

172 actionation of microscopic bioparticles from heterogenous mixtures.

173 ple identified many more eccDNAs with highly heterogenous molecular structure.

174 DAMPs encompass a group of heterogenous molecules, including intracellular molecule

175 Systemic lupus erythematosus (SLE) is a heterogenous multi-systemic autoimmune disease that is a

176 rticles, these organic compounds can undergo heterogenous/multiphase reactions to form more highly ox

177 human skeletal muscle and that of young/aged heterogenous muscle-derived human primary cells (HDMCs)

178 erstanding common biological consequences of heterogenous mutations in complex polygenic conditions i

179 s themselves, resulting in polypeptides with heterogenous N-termini still containing N-terminal exten

180 quence resulted in PHA-E, PHA-L and GNA with heterogenous N-termini, with the majority of the protein

181 red by layer-by-layer self-assembly of Au@Ag heterogenous nanorods (NRs) with rhodamine 6G, and speci

182 ignificant challenges due to the genomically heterogenous nature of HCC.

183 trices often fail to capture the dynamic and heterogenous nature of the in vivo environment, which va

184 variable series of traits in response to the heterogenous nature of the soil environment, but ultimat

185 to allelic variation of coding sequence, the heterogenous nature of the tetraploid potato genome cont

186 sidered to be a highly immunosuppressive and heterogenous neoplasm.

187 , starting from the known disease genes in a heterogenous network constructed from miRNA-gene associa

188 k for the integration of PPI and eQTL into a heterogenous network model, enabling efficient identific

189 chanism shared by molecularly and clinically heterogenous neurodegenerative diseases (NDs).

190 Frontotemporal dementia is a heterogenous neurodegenerative disorder, with about a th

191 Although predominantly nuclear, this heterogenous nuclear ribonuclear protein (hnRNP) has mul

192 Mice lacking heterogenous nuclear ribonuclear protein D (Hnrnpd), als

193 old attachment factor A (SAF-A), also called heterogenous nuclear ribonuclear protein U (hnRNP-U), is

194 This work identified heterogenous nuclear ribonucleoprotein A1 (hnRNP-A1) as

195 Linc1992 bound specifically to heterogenous nuclear ribonucleoprotein L (hnRNPL) and fo

196 l mRNAs that already have no introns or with heterogenous nuclear RNP (hnRNP) complexes.

197 loss of oxygen through ebullition caused by heterogenous nucleation on algae surfaces.

198 Heterogenous oceanic redox conditions are expressed by t

199 ntified in families with tooth agenesis, but heterogenous or multiple genes may be responsible for th

200 d proteins are crucial elements of chromatin heterogenous organization.

201 de detailed protocols to isolate and culture heterogenous organoids from murine and human primary and

202 ble, cost- and time-effective way to monitor heterogenous orthotopic PDX growth.

203 ombinations have the ability to subgroup the heterogenous osteoarthritis population to allow a better

204 rmative neural circuitry may in part explain heterogenous outcomes following ablation procedures in d

205 Tumor fluorescence, however, was heterogenous owing to intratumoral variations in cellula

206 tibility disorder, delineating a genetically heterogenous pathway for the repair of replication-block

207 ernet-based data sharing was used to study a heterogenous patient population in ophthalmic oncology.

208 ecially during self-inhibited DI, produced a heterogenous pattern of constriction inclusive of random

209 Speckle-derived strain reveals a heterogenous pattern of regional heart strain in SSc tha

210 Such complex freezing causes dynamic and heterogenous patterns in water potential and probably in

211 erfere with vessel patency that likely cause heterogenous perfusion and hypoxia thus perpetuating ang

212 limitations of the study include missing and heterogenous phenotype data in some data sets and differ

213 on neuropathic hereditary amyloidosis with a heterogenous phenotype including gastrointestinal, renal

214 However, cells with extra centrioles display heterogenous phenotypes including extended cell cycle ar

215 asingly recognized as consisting of numerous heterogenous phenotypes, their immunopathology, particul

216 EZH2 inhibition results in a heterogenous phenotypic response characterized by senesc

217 low and reef morphology resulted in a highly heterogenous physical environment even within isobaths t

218 P), and used to parameterize a self-avoiding heterogenous polymer (SAHP).

219 ntribute to synergism within a consortium by heterogenous polysaccharide metabolism.

220 CD4 T cells form a heterogenous pool of effector cells in various stages of

221 Ribosomes exist as a heterogenous pool of macromolecular complexes composed o

222 y shaping connectivity within a functionally heterogenous pool of neurons.

223 studies investigating HIV in astrocytes as a heterogenous population have established the relevance o

224 CCKBR-positive cells comprise a molecularly heterogenous population of excitatory and inhibitory neu

225 NK cells are a heterogenous population of innate lymphocytes with diver

226 (DCs) are a phenotypically and functionally heterogenous population of leukocytes with distinct subs

227 ses may help to generate defined ends from a heterogenous population of linear viral DNAs.

228 We identified a heterogenous population of lymphatic endothelial cell cl

229 ic periventricular nucleus (PeVN) comprise a heterogenous population of neurons with both local intra

230 Pediatric VTE encompasses a highly heterogenous population, with variation in age, thrombos

231 d for both research and treatment, given the heterogenous populations identified by current phenomeno

232 ategies are poorly reproducible and generate heterogenous populations of cells.

233 P. falciparum invasion might vary across the heterogenous populations of RBCs found both within and b

234 Twenty-three described heterogenous populations with variant pathology.

235 and lead to efficient strain segregation in heterogenous populations, indicating that in social yeas

236 for compressible air-water two-phase flow in heterogenous porous structures.

237 diators of organ damage fails to explain the heterogenous presentation in patients.

238 f virally induced neurological diseases with heterogenous presentation, an important step for designi

239 rs shown to carry the novel COL4A1 mutation, heterogenous presentations of anterior segment dysgenesi

240 dent that senescence is a highly dynamic and heterogenous process.

241 (DCLDs) are a group of pathophysiologically heterogenous processes that are characterized by the pre

242 pulation asymmetry), stem cells also exhibit heterogenous proliferation-rates; in the long run, howev

243 Amelogenins are a group of heterogenous proteins first identified in developing too

244 ng and depolarizing inputs evoked a markedly heterogenous range of firing responses.

245 ate several sets of rates for sequences with heterogenous rates.

246 challenges presented by the degradation of a heterogenous recalcitrant insoluble substrate by an intr

247 omplexity is maintained during aging despite heterogenous reductions in proliferative capacity, allow

248 etailed description of AVP-ir innervation in heterogenous regions such as the amygdala, bed nucleus o

249 ults show that neurotypical children exhibit heterogenous responses to lexical-semantic violation, im

250 We identified heterogenous ribonucleoprotein A1 (hnRNP A1) as a G-quad

251 Here, we show that the heterogenous ribonucleoprotein A18 (hnRNP A18) RNA Bindi

252 The predominantly nuclear heterogenous ribonucleoprotein A18 (hnRNP A18) transloca

253 Lowering ELL2 expression by transfection of heterogenous ribonucleoprotein F (hnRNP F) or small inte

254 of sun-grown sunflower leaves led to a more heterogenous saturation of electron transport capacity a

255 Importantly, engrafted tumors displayed the heterogenous sensitivity to chemotherapy observed clinic

256 in the mammalian primary visual cortex (V1), heterogenous serotonergic modulation has been observed i

257 f the data identified an organized, but more heterogenous set of audiogram types that was consistent

258 proved SHIFT generalizability in a small but heterogenous set of human pancreatic cancer samples.

259 populates macromolecular complexes of widely heterogenous size and mobility in vivo.

260 es of Abeta42 fibrillar oligomers, including heterogenous size, ability to seed new populations of fi

261 On imaging, a heterogenous soft tissue mass with internal calcific den

262 es by judiciously building feature sets from heterogenous sources and coupling them with measures of

263 ion of malaria hotspots is hampered by their heterogenous spatial distribution, and the laborious nat

264 normal increase of intensity, to a spatially heterogenous speckled pattern, to variably sized patches

265 Mutations in EGR2 are reported to cause a heterogenous spectrum of peripheral neuropathy with wide

266 imodality and trimodality approaches for the heterogenous stage subsets within the stage III designat

267 Inbred and heterogenous strains of mice, in contrast, present with

268 ctive (glomeruli connect to most others with heterogenous strength), or global (glomeruli connect to

269 euroblastoma cell lines typically consist of heterogenous subpopulations of cells that are morphologi

270 of structures exists within this diverse and heterogenous superfamily.

271 ns, and tonsils is similar, but they display heterogenous surface phenotypes.

272 CTCs (RCC-CTCs) remains elusive due to their heterogenous surface receptor expression.

273 Delirium, a heterogenous syndrome, is associated with worse long-ter

274 HFpEF is a heterogenous syndrome.

275 high copy number ligands has been limited to heterogenous systems.

276 087 cells had long and heterogenous telomeres whereas telomeres of 041 cells ha

277 HL colonies are larger and more spatially heterogenous than low-light colonies.

278 re highly conformational and immunologically heterogenous; their subunit pilins are, however, immunol

279 On one interpretation, the heterogenous thermal signals are overridden by homogenou

280 dicate that rates of evolution are extremely heterogenous through time and their interpretation depen

281 tudy indicates that tendon is a surprisingly heterogenous tissue with substantial genetic variation b

282 ively interrogate macromolecule synthesis in heterogenous tissues at the organ, cellular, and molecul

283 f these pathways and interactions within the heterogenous TME will be instrumental to advance this pr

284 E2F is a heterogenous transcription factor and its role in cell c

285 en together, our results newly elucidate the heterogenous transcriptional response of single-cell per

286 Heterogenous transmission is increasingly recognized as

287 f SCD-HeFT patients to 11 years demonstrated heterogenous treatment-related patterns of long-term sur

288 th primary and metastatic tumors, generating heterogenous tumor cell populations.

289 select for fibroblast activation within the heterogenous tumor microenvironment.

290 This results in a highly heterogenous tumor, where a slow-growing, aggressive pop

291 However, CART.BiTE cells eliminated heterogenous tumors in mouse models of glioblastoma.

292 sal relationship among subpopulations within heterogenous tumors.

293 ies tailored to the oligoclonal landscape of heterogenous tumors.

294 However, due to heterogenous tumour growth inherent in glioblastoma, the

295 istent with seeing languages as semiotically heterogenous, using categorial, depictive, and analogic

296 w will focus on our current understanding of heterogenous virulence factor expression and discuss the

297 The tumor microenvironment can be spatially heterogenous, which makes it challenging to fully charac

298 This distribution was heterogenous with regard to dendritic size: PNMT-labeled

299 sponse of ENaC to aldosterone stimulation is heterogenous, with both quantitative and qualitative cha

300 s studied so far, linker histones are highly heterogenous, with numerous nonallelic variants cooccurr