ライフサイエンスコーパス: heteromeric

1 s in eukaryotes) present physiologically are heteromeric.

2 in all mutant receptors, both homomeric and heteromeric.

3 pendently inhibited 5-HT-induced currents in heteromeric 5-HT type 3AB receptors (5-HT(3AB)Rs) (IC(50

4 eterobivalent ligands targeting the putative heteromeric 5-HT(2A)/mGlu(2) receptor complex, based on

5 oxybupropion on mouse homomeric 5-HT(3A) and heteromeric 5-HT(3AB) receptors expressed in Xenopus lae

6 macological effects that bupropion exerts on heteromeric 5-HT(3AB) receptors, in particular when cons

7 mary, we demonstrate that bupropion inhibits heteromeric 5-HT(3AB)Rs as well as homomeric 5-HT(3A)Rs.

8 rs required for light-dependent switching of heteromeric ACCase activity.

9 acid biosynthesis to occur in the absence of heteromeric ACCase, which is encoded in part by the plas

10 contribute to light-dependent regulation of heteromeric ACCase.

11 ledonous plants, expresses a multicomponent, heteromeric acetyl-CoA carboxylase (htACCase), which cat

12 for survival in natural environments, where heteromeric acetyl-coenzyme A carboxylase encoded in par

13 Enzymes in heteromeric, allosterically regulated complexes catalyze

14 hRs) (the homomeric alpha7 receptors and the heteromeric alpha*ss* receptors) as well as the two type

15 ms of glycinergic inhibition are mediated by heteromeric alpha/beta glycine receptors.

16 as single channel recordings, indicates that heteromeric alpha/beta subunit-containing receptors unde

17 The remaining synaptic heteromeric alpha1(Q177K)beta GlyRs had decreased curren

18 We hypothesize that heteromeric alpha1beta3 receptors can be activated by pr

19 f the GlyR alpha2 subunit which results in a heteromeric alpha2beta receptor that is insensitive to e

20 Heteromeric alpha3beta4 nicotinic acetylcholine (ACh) re

21 Heteromeric alpha4beta2* nAChRs typically have two ACh b

22 eta(42) activates both homomeric alpha7- and heteromeric alpha7beta2-nAChR subtypes while preferentia

23 hibition through a specific interaction with heteromeric alphabetaGlyRs containing phosphorylated alp

24 System xc(-) is a heteromeric amino acid cystine/glutamate antiporter that

25 Heteromeric amino acid transporters (HATs) are the uniqu

26 Heteromeric amino acid transporters (HATs) comprise a gr

27 desensitization of recombinant homomeric and heteromeric AMPA and kainate receptors.

28 Our data reveal organizational features of heteromeric AMPARs and provide a framework to decipher A

29 74 and related polyamine toxins at homo- and heteromeric AMPARs in the presence and absence of gamma-

30 Moreover, in heteromeric AMPARs, gamma2 positioning in the complex is

31 However, both heteromeric and homomeric mutant GlyRs became less sensi

32 xin 1 (PcTx1) and zinc, homomeric ASIC1a and heteromeric ASIC1a/2 channels were likely responsible fo

33 characterization of these mutants, we found heteromeric assemblies with two equivalent Glu-binding s

34 The molecular bases of heteromeric assembly and link between Na(+) self-inhibit

35 AMPARs are tetramers formed by homo- or heteromeric assembly of GluA1-4 subunits to produce mult

36 e ICA-069673 are a reliable tool to identify heteromeric assembly of KCNQ2 and KCNQ3.

37 rting the biochemical data showing homo- and heteromeric assembly of the CNGC20 and CNGC19 channel co

38 mbly but had no obvious effect on TRPP2-PKD1 heteromeric assembly.

39 interleukin-1 receptor (TIR)-domain-mediated heteromeric association of DM1 and DM2d.

40 Last, we show that the homomeric and heteromeric B4GALT1/ST6GAL1 complexes can assemble later

41 sient aggregation/disaggregation of homo- or heteromeric building blocks.

42 membrane anchor domains and blocks homo- and heteromeric CerS2/6 complex formation and activity.

43 annels is debated, and their ability to form heteromeric channel assemblies is unclear.

44 homomeric TRPM6 plasma membrane channels or heteromeric channel assemblies with TRPM7.

45 a unique property of Kv1.2 that persists in heteromeric channel complexes and may influence function

46 ctivation, but this property is conferred in heteromeric channel complexes containing even a single K

47 but fail to promote or stabilize KCNQ2/KCNQ3 heteromeric channel expression.

48 vity re-introduces Mg.ATP sensitivity to the heteromeric channel similar to that of TRPM7.

49 ence that Kv7.4 and Kv7.5 form predominantly heteromeric channels and that Kv7 activity is regulated

50 spite these findings, adoption of hERG 1a/1b heteromeric channels as a model for cardiac IKr has been

51 Collectively, the data identify Kv1.1/Kv1.2 heteromeric channels as key regulators of action potenti

52 and Kv7.3 homomeric channels and of Kv7.2/3 heteromeric channels by prolonging the residence time in

53 s subpopulation of muscle afferents as being heteromeric channels composed of ASIC2a and -3 subunits.

54 While L268F severely reduces expression of heteromeric channels in hippocampal neurons without affe

55 Also, Kv subunits usually assemble into heteromeric channels in the central nervous system, gene

56 Studies with heteromeric channels incorporating a key lysine mutation

57 Activity of the heteromeric channels is controlled by cellular availabil

58 c smooth muscle cells or through Kv7.4/Kv7.5 heteromeric channels natively expressed in rat mesenteri

59 nnel subunits preferentially combine to form heteromeric channels that display pharmacological and bi

60 restraining mechanisms can be disengaged in heteromeric channels to form fast and sensitive ATP sign

61 been cloned and found to preferentially form heteromeric channels when expressed in a heterologous ex

62 REK subfamily to assemble to form functional heteromeric channels with novel properties.

63 ects are due to the ability of ORAI2 to form heteromeric channels with ORAI1 and to attenuate CRAC ch

64 ibute to K(+) transport in planta by forming heteromeric channels with other Shaker subunits.

65 Here, we identify LRRC8A heteromeric channels, better known as volume-regulated a

66 For Cx26-HA/Cx30 or Cx30-HA/Cx26 heteromeric channels, the Fab-HA binding distribution wa

67 G1a and hERG1b, consistent with them forming heteromeric channels.

68 le direct evidence that ERG1a and ERG1b form heteromeric channels.

69 g the presence of functional K(v)1.1/K(v)1.2 heteromeric channels.

70 that both subunits contribute to functional heteromeric channels.

71 co-expressed with wild-type subunits to form heteromeric channels.

72 activator ICA-069673 to identify assembly of heteromeric channels.

73 composition to explore the functionality of heteromeric channels.

74 Examples of such PPIs are heteromeric chemokine interactions that are potentially

75 establish the first purification system for heteromeric cis-PT and show that both NgBR and hCIT subu

76 Our studies establish the basis of heteromeric ClpP1P2 assembly and function, reveal tight

77 proteases function via collaboration of the heteromeric ClpP1P2 peptidase with a AAA+ partner, ClpX

78 3, with or without optional exon 5, produced heteromeric CNGA3 + CNGB3 channels exhibiting an approxi

79 e mutated the AaegGr3 gene, a subunit of the heteromeric CO2 receptor in Aedes aegypti mosquitoes.

80 opus oocytes expressing recombinant homo- or heteromeric combinations of GluA1, GluA2, and GluA3 in t

81 this study, we investigated the behavior of heteromeric combinations of wild-type (WT) and mutant So

82 minants responsible for the formation of the heteromeric complex are still being studied.

83 BAK1 and demonstrates that formation of the heteromeric complex is the molecular switch for transmem

84 rugs and their crosstalk mechanism through a heteromeric complex of G protein-coupled receptors.

85 een algae, and most plants, this enzyme is a heteromeric complex requiring four different subunits fo

86 cell growth and proliferation by acting in a heteromeric complex to inhibit the mammalian target of r

87 suppressor p53, can work separately and as a heteromeric complex to restrain p53's functions.

88 that the cell adhesion molecule Cdon forms a heteromeric complex with the Hh receptor Patched 1 (Ptc1

89 we report that the AT1 receptor preformed a heteromeric complex with the receptor for advanced glyca

90 -5 (PP5) increased its association with this heteromeric complex, while apoptosis signal regulating k

91 c interactions, even within the context of a heteromeric complex.

92 for ISA2 and sta8 mutants lack the ISA1.ISA2 heteromeric complex.

93 ighly conserved in eukaroytes; they can form heteromeric complexes (known as C3POs) and participate i

94 of both ligands and receptors, representing heteromeric complexes accurately.

95 py analysis indicates that NFP and LYK3 form heteromeric complexes at the cell periphery in M. trunca

96 e quaternary structure of alpha1A/B-AR:CXCR4 heteromeric complexes by targeting transmembrane helix 2

97 ophysiology, but could not determine whether heteromeric complexes have a fixed subunit stoichiometry

98 The ability of CRFRs to form heteromeric complexes in association with regulatory pro

99 ow that the two known CRFRs interact to form heteromeric complexes in HEK293 cells coexpressing both

100 tion of preassembled apo-GHSR1a:DRD1:Galphaq heteromeric complexes in hippocampal neurons.

101 vidence for the existence of MT(2) /5-HT(2C) heteromeric complexes in mouse brain.

102 CXCR4 silencing reduced alpha1A/B-AR:CXCR4 heteromeric complexes in VSMC and abolished phenylephrin

103 Although most heteromeric complexes of known structure have even stoic

104 Most AMPA receptors (AMPARs) are heteromeric complexes of subunits GluA1/GluA2 or GluA2/G

105 n and proteasomal degradation resulting from heteromeric complexes of wild-type and mutant SPOP prote

106 Septins form linear, palindromic heteromeric complexes that can assemble in filaments and

107 as a model archaeal system, we show that the heteromeric complexes that can be assembled from its sev

108 meodomain proteins function as components of heteromeric complexes that contain one member each of th

109 Inflammasomes are multi-protein heteromeric complexes that sense molecular patterns that

110 t all HAS isoenzymes form homomeric and also heteromeric complexes with each other.

111 c proteins appears to enable the assembly of heteromeric complexes with more unique components.

112 of HAS isoenzymes to form both homomeric and heteromeric complexes with potentially important functio

113 y, we showed that BAM1 is capable of forming heteromeric complexes with RPK2.

114 al correction of such defects, especially in heteromeric complexes with structurally diverse constitu

115 e CaV1.2 channels in cardiomyocytes exist as heteromeric complexes with the pore-forming CaValpha1, C

116 er member of the same subfamily, TRPC4, form heteromeric complexes with the TRPC1 subunit (TRPC1/5 an

117 complex, as well as two of the most studied heteromeric complexes, i.e., delta-OR/mu-OR and delta-OR

118 ealing that these proteins can assemble into heteromeric complexes, induced by Ca(2+) , to cooperativ

119 As they form heteromeric complexes, the E-Syts confer cytosolic Ca(2+

120 F1R and CRF2betaR, along with actin in these heteromeric complexes.

121 least in part, on the formation of A2AR-CB1R heteromeric complexes.

122 e CaV1.2 channels in cardiomyocytes exist as heteromeric complexes.

123 Ps, revealed many previously uncharacterized heteromeric complexes.

124 hat 5-HT1A and GRPR may function as receptor heteromeric complexes.

125 ional effects, depending on the homomeric or heteromeric composition of the target, its kinetic state

126 t Xist forms the Xi compartment by seeding a heteromeric condensate that consists of ubiquitous RNA-b

127 ional studies revealed that, in homomeric or heteromeric configuration with K(V)7.2 and/or K(V)7.3 su

128 Finally, the formation of heteromeric connexons resulted in significantly increase

129 d-type, confirming the enhanced formation of heteromeric connexons.

130 ciates as a probable tetramer and also forms heteromeric contacts with pKM101-encoded TraI relaxase,

131 ardly rectifying shape, in contrast to their heteromeric counterparts.

132 Both the homomeric CpomOrco and heteromeric CpomOrco + OR complexes can be activated by

133 study demonstrates that ORAI1 and ORAI2 form heteromeric CRAC channels, in which ORAI2 fine-tunes the

134 irst time that the molecular architecture of heteromeric Cx channels has been revealed, thus providin

135 Investigating properties of heteromeric Cx channels is challenging considering the h

136 urally, the stoichiometry and arrangement of heteromeric Cx channels remain unknown.

137 4G, but dependent on subunits i and g of the heteromeric eIF3 complex.

138 mGlu5) receptors can form previously unknown heteromeric entities with distinctive functional propert

139 n one isoform of the Na, K-ATPase (NKA), the heteromeric enzyme that creates the Na(+) and K(+) gradi

140 ls, fungal, and long-chain plant cis-PTs are heteromeric enzymes composed of two distantly related su

141 in Purkinje cells are presumably mediated by heteromeric erg1/erg3 or modified erg1 channels.

142 ture illustrates the molecular principles of heteromeric GABA(A) receptor organization and provides a

143 e to many anesthetic drugs that modulate the heteromeric GABA(A) receptor, it maintains a rich and mu

144 s to generate accurate structural models for heteromeric GABA(A) receptors have been hampered by the

145 ns form homotypic rather than heterotypic or heteromeric gap junctions.

146 ridophores, suggest that both connexins form heteromeric gap junctions.

147 a cryo-electron microscopy structure of the heteromeric GluA1/2 receptor associated with two transme

148 ues in the nanomolar range (252-356 nM), and heteromeric GluA1/A2 and GluA2/A3 receptors nonselective

149 Preferential AMPAR subunit assembly favors heteromeric GluA1/GluA2 complexes.

150 toinactivation of both homomeric (GluA2) and heteromeric (GluA2:GluA1) AMPA receptors.

151 Altogether, our data unveil heteromeric GluClR assemblies having three alpha and two

152 We further characterized this heteromeric GluClR mutant as a receptor having a third G

153 ignal approach for the study of a variety of heteromeric glutamate-gated ion channel receptors with d

154 using recombinantly expressed homomeric and heteromeric glycine receptor channels, including their s

155 ynaptic inhibition through the activation of heteromeric glycine receptors (GlyRs) composed primarily

156 )) enhances receptor activation in homo- and heteromeric glycine receptors.

157 ld type) but reduced only marginally that of heteromeric GlyRs (0.96; cf. 0.99 for wild type).

158 ic homomeric GlyRs, rather than postsynaptic heteromeric GlyRs (which mediate glycinergic synaptic tr

159 glycinergic synaptic transmission), because heteromeric GlyRs are less affected by many startle muta

160 ecay of synaptic currents mediated by mutant heteromeric GlyRs is expected to reduce charge transfer

161 Recombinant heteromeric GlyRs were less impaired than homomers by th

162 ic homomeric GlyRs (rather than postsynaptic heteromeric GlyRs), because homomeric GlyRs are more sen

163 tely 10- and 7-fold faster for homomeric and heteromeric GlyRs, respectively.

164 TBP modulated synaptic, presumably alphabeta heteromeric, GlyRs only after priming with PGE2.

165 the paucity of reliable methods for probing heteromeric GPCR interactions in situ.

166 LiGPPS.LSU and LiGPPS.SSU1 formed an active heteromeric GPPS, while LiGPPS.LSU and LiGPPS.SSU2 did n

167 nificant potency enhancement was observed at heteromeric halpha3beta2 and halpha9alpha10 nAChRs.

168 ly sequestering HdrR in a membrane-localized heteromeric HdrR/M complex.

169 Heterologous expression of these hyperactive heteromeric hemichannels increases cell membrane permeab

170 he slow inactivating current mediated by the heteromeric hP2X2/3 channel.

171 found inhibition of both homomeric hP2X3 and heteromeric hP2X2/3 receptors, an effect mediated by eff

172 , providing insights into their roles in the heteromeric HrpRS co-complex.

173 bunit-selective ligands affect the gating of heteromeric iGluRs, namely their activation and desensit

174 for analysis of two-color images to resolve heteromeric interactions between molecules labeled with

175 Heteromeric interactions between the catalytically impai

176 computationally expedient means of measuring heteromeric interactions in cellular environments.

177 Here we investigated the homomeric and heteromeric interactions of TbetaRIII with TbetaRI and T

178 ed type-4 BRET, which detects both homo- and heteromeric interactions using induced multimerization o

179 ric interactions for GnT1IP-L in the ER, and heteromeric interactions with MGAT1 in the Golgi.

180 e energy transfer, are unsuited to reporting heteromeric interactions.

181 residues, to create a beta(3)(+)alpha(1)(-) heteromeric interface in the homomeric human beta(3) GAB

182 ic erythropoietin receptor (EpoR) and at the heteromeric interferon gamma receptor (IFNGR).

183 mary cilia, where they are thought to form a heteromeric ion channel complex.

184 s in the cochlea, adaptation is regulated by heteromeric ion channels composed of Kv1.1 and Kv1.2 sub

185 We conclude that hERG1b preferentially forms heteromeric ion channels with hERG1a at the plasma membr

186 demonstrate that individual monomers within heteromeric IP3Rs contributed equally toward generating

187 tin signaling and almost completely abrogate heteromeric (JAK2-JAK1) IFN-gamma signaling, potentially

188 ment of the potency of kappaM-RIIIJ block of heteromeric K(+) channel-mediated currents in heterologo

189 arrangement of individual subunits in native heteromeric K(+) channels and establishing their physiol

190 The vast complexity of native heteromeric K(+) channels is largely unexplored.

191 al tools that systematically target specific heteromeric K(v) channel complexes that operate in nativ

192 bunits, and also GluK1/GluK5 and GluK2/GluK5 heteromeric kainate receptors with equal potency.

193 igh-resolution structure currently exists of heteromeric kainate receptors.

194 s is to mediate subtype-specific assembly of heteromeric KCNQ channels.

195 specific Kv7 activator to assess assembly of heteromeric KCNQ2/KCNQ3 (Kv7.2/Kv7.3) channels and demon

196 , L166Q, and G83V) on homomeric (Kir4.1) and heteromeric (Kir4.1-Kir5.1) channel function.

197 onal Kv11.3 channels and the more ubiquitous heteromeric Kv11.1a/1b channels.

198 24a showed also higher potency in activating heteromeric Kv7.2/Kv7.3 and homomeric Kv7.4 channels.

199 Heteromeric Kv7.4/7.5 channels displayed intermediate re

200 -069673 on homomeric human Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels exogenously expressed in

201 nce of homomeric Kv7.4 and Kv7.5, as well as heteromeric Kv7.4/7.5 channels, and induced a negative s

202 the alpha2(+)/alpha2(-) binding site on the heteromeric low sensitivity alpha2beta2 nAChR and valida

203 An unusual set of Francisella regulators-the heteromeric macrophage growth locus protein A (MglA)-str

204 Acetylcholine receptors (AChRs) are heteromeric membrane proteins essential for neurotransmi

205 ng MORF-MORF interactome identifies specific heteromeric MORF protein interactions in plastids and in

206 ased recruitment of MDM4 by the homomeric or heteromeric mutant p53(V172F) complex that inhibits p53-

207 gnificantly increased the sensitivity of the heteromeric mutant receptor to both Glu and IVM, and imp

208 ibitory (VGAT) neurons across A1 layers; (2) heteromeric nAChR binding across A1 layers; and (3) nACh

209 0A,N11R,E14A) indicated that the predominant heteromeric nAChR expressed by human adrenal chromaffin

210 To understand how alpha5DN impairs heteromeric nAChR functions, we coexpressed alpha4, alph

211 Although the alpha9/10 heteromeric nAChR is an important component of vestibula

212 n A1 nAChR subunit expression across layers, heteromeric nAChR receptor binding, and nAChR excitabili

213 udies show a significant age-related loss of heteromeric nAChR receptor number, which supports patch

214 neurons, the alpha5 subunit is essential for heteromeric nAChR-induced intracellular-free Ca(2+) conc

215 l mechanisms that govern agonist efficacy in heteromeric nAChRs and related ligand-gated ion channels

216 nAChR subtypes include high-affinity heteromeric nAChRs commonly composed of alpha4 and beta2

217 uctural subunit, much like a beta subunit of heteromeric nAChRs, providing only complementary compone

218 st site and perhaps an allosteric action for heteromeric nAChRs.

219 urons, probably mediated by beta2-containing heteromeric nAChRs.

220 DCC and UNC5 homologs are proposed to form a heteromeric netrin-receptor complex to mediate a chemore

221 this NLR pair thus suggests that activity of heteromeric NLR signaling complexes depends on the sum o

222 he N-methyl-d-aspartate (NMDA) receptors are heteromeric non-selective cation channels that require t

223 dependent behaviors requires the activity of heteromeric odorant receptor (OR) ion channel complexes

224 Insect odorant receptors are heteromeric odorant-gated cation channels comprising a c

225 odorant ligands to the variable subunits of heteromeric olfactory receptors.

226 Strikingly, heteromeric oligomer formed by Cx43/Cx26 (syndromic muta

227 al compound addition protocol, revealed that heteromeric OR (ORx/Orco) function was susceptible to st

228 nnels in hPECs and prostate cancer cells are heteromeric Orai1/Orai3 channels with an increased Orai1

229 irements for the activation of homomeric and heteromeric Orco channel complexes.

230 ction between the alpha6beta4 nAChRs and the heteromeric P2X2/3 receptor.

231 Purinergic homomeric P2X3 and heteromeric P2X2/3 receptors are ligand-gated cation cha

232 sic neuronal excitability is mediated by the heteromeric P2X2/3 receptors.

233 eochromocytoma cells to form light-activated heteromeric P2X2/3 receptors.

234 The inference that p53 was unstable as a heteromeric p53(wt)/p53(V172F) complex was confirmed in

235 at the active form of PaClpP2 is a part of a heteromeric PaClpP1(7) P2(7) tetradecamer that is requir

236 ular architectures from charge-complementary heteromeric pairs of collagen-mimetic peptides (CMPs).

237 P35 (Nucleotide-Binding Protein 35 kDa), the heteromeric partner of CFD1 in metazoa, functions on its

238 enhances activation by agonist bound to its heteromeric partner, and a unique conformational pathway

239 rs can be assembled from either homomeric or heteromeric pentameric subunit combinations.

240 east, the main in vivo activities are due to heteromeric Pmt1-Pmt2 and homomeric Pmt4 complexes.

241 lls express PC1-L1 and PC2, which may form a heteromeric polycystin channel complex on primary cilia.

242 critical mechanical nociception function for heteromeric PPK and Balboa channels in vivo.

243 s are the first demonstration of an obligate heteromeric PRMT, and they suggest that enzyme-prozyme o

244 cence of P. leiognathi is generated within a heteromeric protein complex composed of the bacterial lu

245 ent decades, many thousands of homomeric and heteromeric protein complex structures have been determi

246 a general mechanism facilitating assembly of heteromeric protein complexes involved in a range of bio

247 The formation of heteromeric protein complexes were validated by coimmuno

248 For instance, for heteromeric protein complexes, excess nonstoichiometric

249 in 10% of a representative set of bacterial, heteromeric protein complexes.

250 t self-chaperoning is a robust mechanism for heteromeric protein folding and assembly that could also

251 LiGPPS was heteromeric protein, consisting of a large subunit (LiGP

252 Class I RNRs are heteromeric proteins built up by alpha and beta subunits

253 nto the nanomechanics of such multidomain or heteromeric proteins.

254 howed that rhizobium LCOs are perceived by a heteromeric receptor complex of distinct Lys motif (LysM

255 mbrane helix 2 of CXCR4 and depletion of the heteromeric receptor complexes by CXCR4 knockdown inhibi

256 In addition, heteromeric receptor complexes have been identified.

257 Heteromeric receptor complexes of P2X7A and P2X7L are pr

258 he functional presentation and activation of heteromeric receptor complexes of transmembrane, dual-sp

259 competent death receptors through formation heteromeric receptor complexes.

260 It is a heteromeric receptor composed only of alpha subunits.

261 oes, which is detected by a highly conserved heteromeric receptor consisting of three 7-transmembrane

262 in this domain abolishes Neto2 modulation of heteromeric receptor desensitization.

263 for the higher affinity of nicotine for the heteromeric receptor.

264 -evoked current, indicating that most of the heteromeric receptors contained beta4 ligand-binding sit

265 momeric nAChR composed of alpha9 subunits or heteromeric receptors containing alpha9 and alpha10 subu

266 nt propensities to form homomeric or various heteromeric receptors expressed on cell surface, but the

267 Thus, the synaptic function of heteromeric receptors is likely to be impaired by the mu

268 s mirrored by subunit-selective agonists and heteromeric receptors that contain binding-impaired subu

269 fect on activation properties in alpha1beta3 heteromeric receptors.

270 and reduced channel conductance in homo- and heteromeric receptors.

271 the latter is suggestive of a population of heteromeric receptors.

272 Heteromeric rings of pRNA demonstrated that one or two c

273 to the structural asymmetry that arises from heteromeric self-association.

274 A common design principle of heteromeric signaling proteins is the use of shared subu

275 Recently, four additional heteromeric structures were reported, highlighting key r

276 nd new mechanistic insights into the role of heteromeric subunit assembly for regulation of vascular

277 libenclamide and carbamazepine stabilize the heteromeric subunit interface critical for channel bioge

278 spatial organization and drives formation of heteromeric TbetaRI/TbetaRII complexes and Smad activati

279 ed with GluN2 (and/or GluN3) subunits into a heteromeric tetramer.

280 Functional receptors are homo- or heteromeric tetramers with each subunit contributing a r

281 TnsA and TnsB together form the heteromeric Tn7 transposase, and TnsD is a target-select

282 controlled by a second hitherto unrecognized heteromeric transcription factor named BisDC.

283 As a group, heteromeric transposase elements utilize diverse target

284 coded genes (tnsABCDE) including an atypical heteromeric transposase.

285 uggests that distantly related elements with heteromeric transposases exist with alternate targeting

286 We identified the first heteromeric TRP channels composed of subunits from 3 dif

287 I(4,5)P(2) sensitivity between homomeric and heteromeric TRPC channels.

288 synovial sarcoma cells which is mediated by heteromeric TRPC4/C1 channels and Na(+) loading.

289 the plant Phyllanthus engleri which acts via heteromeric TRPC4/C1 channels to cause cytotoxicity in s

290 82 cells with biophysical characteristics of heteromeric TRPC4/C1 channels.

291 mass spectrometric analysis of homomeric and heteromeric TRPM7 and TRPM6 channels identified phosphor

292 Strikingly, the activity of heteromeric TRPM7/M6 channels is independent of intracel

293 Co-expression of TRPM7 and TRPM6 produces heteromeric TRPM7/M6 channels with altered pharmacology

294 Functionally, this heteromeric TRPV4-C1-P2 channel mediates the flow-induce

295 The analysis demonstrated the formation of a heteromeric TRPV4-C1-P2 complex in primary cultured rat

296 KCNE3 (MiRP2) forms heteromeric voltage-gated K(+) channels with the skeleta

297 overed that LRRC8 gene family members encode heteromeric VRAC composed of LRRC8A plus LRRC8B-E, which

298 All LRRC8 subunits of heteromeric VRAC were expressed during myotube formation

299 ggest the existence of at least two distinct heteromeric VRACs in astroglial cells.

300 findings point to the existence of multiple heteromeric VRACs in the same cell type: LRRC8A/D-contai