1 Two-dimensional 1H-
15N heteronuclear NMR spectra indicate that H24 is present i
2 1H and
15N heteronuclear NMR spectroscopy has allowed the direct lo
3 (1H,
15N)
heteronuclear NMR experiments aided in assigning the imi
4 Two-dimensional 1H homonuclear and 13C-
1H heteronuclear NMR spectroscopy of native tx5a isolated f
5 and heteronuclear NMR spectra and 1H-15N
3D heteronuclear NMR spectra.
6 ined using a strategy based on 2D, 3D and
4D heteronuclear NMR experiments, and on perdeuterated 13C/
7 e-dimensional (3D) and four-dimensional (
4D)
heteronuclear NMR spectroscopy.
8 ing one- and two-dimensional (1)H, (13)C
and heteronuclear NMR experiments under continuous flow.
9 is issue we establish by crystallography
and heteronuclear NMR spectroscopy that the imidazole of His
10 We used circular dichroism
and heteronuclear NMR to investigate the secondary structure
11 Using UV melting, gel electrophoresis
and heteronuclear NMR, we investigated effects of various si
12 erved HNF-3 homologous protein, Genesis,
and heteronuclear NMR, circular dichroism, DNA gel-shift ass
13 Using (1)H
and heteronuclear NMR spectroscopy, we have characterized on
14 Homo
and heteronuclear NMR spectroscopy have been used to determi
15 High-resolution homo-
and heteronuclear NMR data have been used for structure dete
16 ntent, leading to remarkably clean homo-
and heteronuclear NMR spectra of the serum metabolome that c
17 We show by homo-
and heteronuclear NMR spectroscopy that the covalent Adriamy
18 -dimensional and three-dimensional homo-
and heteronuclear NMR spectroscopy.
19 dodecylphosphocholine micelles by homo-
and heteronuclear NMR spectroscopy.
20 ins of the ribozyme, as studied by homo-
and heteronuclear NMR spectroscopy.
21 rometry (MS), tandem MS, and homonuclear
and heteronuclear NMR analyses.
22 A broad suite of homonuclear
and heteronuclear NMR correlation experiments on dehydrated
23 ance restraints derived from homonuclear
and heteronuclear NMR experiments were used to calculate str
24 achieved by two-dimensional homonuclear
and heteronuclear NMR experiments, is reported for the first
25 ained using multidimensional homonuclear
and heteronuclear NMR experiments.
26 obtained from 1H and 15N 2D homonuclear
and heteronuclear NMR spectra and 1H-15N 3D heteronuclear NM
27 -dimensional (2D) (1)H/(31)P homonuclear
and heteronuclear NMR spectra of blood; (b) mapping the cent
28 peaks in the amide region of homonuclear
and heteronuclear NMR spectra.
29 de has been determined using homonuclear
and heteronuclear NMR spectroscopy, and compared to the unbo
30 rmined using two-dimensional homonuclear
and heteronuclear NMR spectroscopy.
31 were completely assigned by homonuclear
and heteronuclear NMR spectroscopy.
32 ncomplexed E-domain using 2D homonuclear
and heteronuclear NMR spectroscopy.
33 ructure was determined using homonuclear
and heteronuclear NMR techniques on non-labeled and15N-label
34 gated using a combination of homonuclear
and heteronuclear NMR techniques.
35 binding site was studied by homonuclear
and heteronuclear NMR.
36 s were examined by mutagenesis, kinetic,
and heteronuclear NMR studies.
37 hia coli was investigated by mutagenesis
and heteronuclear NMR methods.
38 Previous mutagenesis
and heteronuclear NMR spectroscopy studies directed toward t
39 By deletion mutagenesis
and heteronuclear NMR spectroscopy we localised a globular d
40 near-UV CD, fluorescence, urea titration
and heteronuclear NMR experiments, we show that three amino
41 dichroism) was unaffected by ligand-
binding,
heteronuclear NMR studies revealed subtle local and nonl
42 Here, using
both heteronuclear NMR and single crystal X-ray diffraction,
43 th RbfA, determined in solution at pH 5.0
by heteronuclear NMR methods.
44 ine domain of fractalkine (residues 1-76)
by heteronuclear NMR methods.
45 d-denatured state of barstar was assigned
by heteronuclear NMR experiments and structural parameters
46 residues per monomer, have been assigned
by heteronuclear NMR methods with the 15N- and 13C-labeled
47 red the autocatalytic conversion of BACE1
by heteronuclear NMR spectroscopy and used chemical shift p
48 Sxl (Sxl-RBD1 + 2) has been characterized
by heteronuclear NMR.
49 an detection at micromolar concentrations
by heteronuclear NMR.
50 il nature of zeta(cyt) was also confirmed
by heteronuclear NMR.
51 nd the catalytic domain of FKBP38 derived
by heteronuclear NMR spectroscopy.
52 ture of the NC-SL2 complex was determined
by heteronuclear NMR methods using (15)N,(13)C-isotopically
53 ate 8.1 in these reactions was determined
by heteronuclear NMR to be a configurationally stable, alph
54 However, here we establish
by heteronuclear NMR and other spectroscopic methods that T
55 gnaling partner, TSG101-UEV, as evidenced
by heteronuclear NMR spectroscopy.
56 nt helix at low temperature as identified
by heteronuclear NMR relaxation measurements, secondary che
57 of the 19-residue SL2 oligoribonucleotide
by heteronuclear NMR methods.
58 flexibility in the native state as probed
by heteronuclear NMR spectroscopy and multiple conformer si
59 d the pH titration of individual residues
by heteronuclear NMR.
60 beta-chains of oxyhemoglobin, as revealed
by heteronuclear NMR spectra of chain-selectively labeled s
61 e applied differential scanning
calorimetry,
heteronuclear NMR spectroscopy, and solution small-angle
62 n D(28K) we performed detailed
complementary heteronuclear NMR and microelectrospray mass spectrometr
63 been labeled with 13C and 15N, and
complete heteronuclear NMR resonance assignments have been comple
64 using severe line broadening in
conventional heteronuclear NMR experiments.
65 or enzymatic oxidation in rat liver
cytosol;
heteronuclear NMR experiments revealed that oxidation oc
66 K(D) = 52 nM) was determined by standard 3-
D heteronuclear NMR methods.
67 These (1)H-
detected heteronuclear NMR spectra can have their sensitivity enh
68 the 15N nuclear spins using proton-
detected heteronuclear NMR spectroscopy.
69 plication of two, three and four-
dimensional heteronuclear NMR techniques on samples containing unifo
70 (U1A117) determined using multi-
dimensional heteronuclear NMR is presented.
71 Multi-
dimensional heteronuclear NMR spectroscopy has been used to obtain s
72 iptional repressor MBD1 by multi-
dimensional heteronuclear NMR spectroscopy.
73 9)) has been determined by multi-
dimensional heteronuclear NMR spectroscopy.
74 using two-dimensional and three-
dimensional heteronuclear NMR spectroscopy.
75 has been determined using three-
dimensional heteronuclear NMR spectroscopy.
76 has been determined using three-
dimensional heteronuclear NMR spectroscopy.
77 using two-dimensional and three-
dimensional heteronuclear NMR spectroscopy.
78 ar NMR in conjunction with three-
dimensional heteronuclear NMR.
79 n organic solvents and using two-
dimensional heteronuclear NMR in conjunction with magic-angle spinni
80 riched bile salts along with two-
dimensional heteronuclear NMR methods.
81 h as may be obtained from a two-
dimensional,
heteronuclear NMR spectrum), the inverse mode of SPARIA
82 Here, we
employ heteronuclear NMR spectroscopy to characterize a monomer
83 We have
employed heteronuclear NMR methods to determine the pK(a) values
84 We propose a set of
exclusively heteronuclear NMR experiments to investigate these featu
85 effects (fluoro, nitrobenzoate), handles
for heteronuclear NMR ((19)F:fluoro; pentafluorophenyl or pe
86 he T and A bases, as previously deduced
from heteronuclear NMR measurements by Zhao et al.
87 unfolded BPTI analogue were determined
from heteronuclear NMR relaxation measurements at similar sol
88 ntains a large unfolded region identified
in heteronuclear NMR experiments.
89 Multidimensional heteronuclear NMR analysis showed that the binding mode
90 Multidimensional heteronuclear NMR and molecular modeling studies are rep
91 Multidimensional heteronuclear NMR techniques were applied to study a pro
92 A
multidimensional heteronuclear NMR study has demonstrated that a guanine-
93 Comparison of proton and
multidimensional heteronuclear NMR spectra of individual modules to those
94 structure, as determined by
multidimensional heteronuclear NMR analysis.
95 149, has been determined by
multidimensional heteronuclear NMR spectroscopy.
96 get RNA, has been solved by
multidimensional heteronuclear NMR spectroscopy.
97 eceptor, has been solved by
multidimensional heteronuclear NMR spectroscopy.
98 it of TC has been solved by
multidimensional heteronuclear NMR spectroscopy.
99 the structure was solved by
multidimensional heteronuclear NMR, revealing many structural features of
100 29-231)] is investigated by
multidimensional heteronuclear NMR.
101 of arginine was studied by
multidimensional heteronuclear NMR.
102 Dcp has been determined by
multidimensional heteronuclear NMR.
103 28)) has been determined by
multidimensional heteronuclear NMR.
104 693) has been determined by
multidimensional heteronuclear NMR.
105 estraints were derived from
multidimensional heteronuclear NMR spectra.
106 Recent developments in
multidimensional heteronuclear NMR spectroscopy and large-scale synthesis
107 omain using high resolution
multidimensional heteronuclear NMR techniques.
108 ed solubility dictated that
multidimensional heteronuclear NMR experiments had to be performed at a p
109 Using traditional
multidimensional heteronuclear NMR, even for single smGs, numerous experi
110 Phe13 in MIP-1beta, we used
multidimensional heteronuclear NMR to determine the three-dimensional str
111 ed to high resolution using
multidimensional heteronuclear NMR methods.
112 ucture of this mutant using
multidimensional heteronuclear NMR methods.
113 of the two sequences using
multidimensional heteronuclear NMR spectroscopy, and the structure was fo
114 rminal EF-hand domain using
multidimensional heteronuclear NMR.
115 modification, and two-dimensional (1)H-(15)
N heteronuclear NMR relaxation experiments.
116 Comparative two-dimensional (1)H, (15)
N heteronuclear NMR spectra indicate that the double mutan
117 ecylphosphocholine micelles using (1)H/(15)
N heteronuclear NMR spectroscopy.
118 s a function of temperature using (1)H-(15)
N heteronuclear NMR spectroscopy.
119 We used a combination
of heteronuclear NMR experiments and molecular dynamics sim
120 15N-labeled PSA, we applied a combination
of heteronuclear NMR methods, such as heteronuclear single
121 er acidic conditions, using a combination
of heteronuclear NMR, analytical ultracentrifugation, and c
122 roach is presented for the interpretation
of heteronuclear NMR spin relaxation data in mobile protein
123 of the apo-domain was determined by means
of heteronuclear NMR spectroscopy and found to be a flatten
124 P with and without bound ligands by means
of heteronuclear NMR.
125 reliable way of enhancing the sensitivity
of heteronuclear NMR in dilute mixtures of metabolites.
126 In this paper, we present a series
of heteronuclear NMR experiments for the direct observation
127 ure in solution was improved with the use
of heteronuclear NMR data.
128 An analysis
of heteronuclear-NMR-based screening data is used to derive
129 tural (13)C abundance, metabolomics based
on heteronuclear NMR is limited by sensitivity.
130 structure we report for the A form, based
on heteronuclear NMR restraints, involving a total of 1288
131 Here, using
primarily heteronuclear NMR complemented by fluorescence spectrosc
132 A high
quality heteronuclear NMR spectrum of HCV NS5B(Delta21) has been
133 ment are amenable to further high-
resolution heteronuclear NMR analysis.
134 A range of double and triple
resonance heteronuclear NMR has been used to obtain nearly complet
135 Double- and triple-
resonance heteronuclear NMR spectroscopy have been used to determi
136 Standard heteronuclear NMR methods were used to assign the protei
137 In this
study,
heteronuclear NMR methods were used to study the structu
138 These results indicate
that heteronuclear NMR, used with chain-selective isotopic la
139 ments, and illustrates the usefulness of
the heteronuclear NMR experiments.
140 ns and the first equivalent of metal
through heteronuclear NMR relaxation measurements.
141 ate was then directly demonstrated using
two heteronuclear NMR methods, an 1H-(13)C HSQC experiment a
142 rized in mutational studies, and here we
use heteronuclear NMR spectroscopy to identify the rat CD48
143 In this study, we
use heteronuclear NMR techniques to study drug binding to [m
144 We have
used heteronuclear NMR methods to probe the loop conformation
145 We have now
used heteronuclear NMR spectroscopy to determine its conforma
146 Here, we
used heteronuclear NMR spectroscopy and molecular modeling to
147 Using heteronuclear NMR (13)C-(15)N-(1)H correlation experimen
148 Using heteronuclear NMR methods we have investigated the domai
149 Using heteronuclear NMR spectroscopy, we demonstrate that a 13
150 Using heteronuclear NMR spectroscopy, we demonstrated that the
151 Using heteronuclear NMR spectroscopy, we have determined the b
152 Using heteronuclear NMR spectroscopy, we have determined the s
153 humanized anti-HER2 antibody (Hu4D5-8)
using heteronuclear NMR spectroscopy.
154 polypeptide dynamics of human FADD-DD
using heteronuclear NMR spectroscopy of (15)N and (13)C,(15)N-
155 protein unfolded in 6 M urea in detail
using heteronuclear NMR.
156 e in its free form has been determined
using heteronuclear NMR and compared to the structure of the p
157 dust mite allergen Der p 2, determined
using heteronuclear NMR methods.
158 eptide bound to BIV TAR RNA determined
using heteronuclear NMR methods.
159 (Ku86CTR(592-709)) has been determined
using heteronuclear NMR spectroscopy and dynamical simulated a
160 rtase (PC) 1 pro-domain was determined
using heteronuclear NMR spectroscopy and is the first structur
161 hydrogen isotope exchange experiments
using heteronuclear NMR spectroscopy.
162 Here,
using heteronuclear NMR spectroscopy, we reveal that AcpP-teth
163 ate kinase (PGK) has been investigated
using heteronuclear NMR spectroscopy.
164 tructure for the bound form of TAR RNA
using heteronuclear NMR.
165 cross-linked DNA fragment was studied
using heteronuclear NMR techniques.
166 Studies
using heteronuclear NMR showed a steep decrease in (1)H-(15)N
167 ed modes to be characterized in analogy
with heteronuclear NMR.