ライフサイエンスコーパス: heterosynaptic

1 nal motoneurons were frequency-dependent and heterosynaptic.

2 icity induced by PAS and cTBS interacts in a heterosynaptic and bidirectional manner.

3 icity presents unique features as it is both heterosynaptic and homosynaptic in nature and requires C

4 types of LTD in vivo, including associative, heterosynaptic and homosynaptic LTD.

5 This form of plasticity is heterosynaptic and is expressed as an increase (long-ter

6 The two mechanisms, homosynaptic and heterosynaptic, are the distinguishing characteristics o

7 The effects of priming also were heterosynaptic, because the induction of synaptic plasti

8 We show that this is readily achieved by heterosynaptic but not standard Hebbian rules.

9 term potentiation (LTP), coactivation of the heterosynaptic CF input, which evokes large dendritic ca

10 These heterosynaptic changes are weight-dependent and balanced

11 tion to Hebbian-type associative plasticity, heterosynaptic changes at synapses that were not active

12 Moreover, heterosynaptic changes can accompany homosynaptic plasti

13 Induction of these heterosynaptic changes depended on the rise of intracell

14 The direction of heterosynaptic changes is weight-dependent, with balance

15 Interestingly, the net outcome of heterosynaptic changes was different in FS and non-FS ne

16 n both fast-spiking (FS) and non-FS neurons, heterosynaptic changes were weight-dependent, because th

17 ynaptic mGluR5 receptors and facilitation of heterosynaptic communication between multiple neurons.

18 lbeit with differential requirements for the heterosynaptic communication of excitatory signals to in

19 ell-studied neurons, such as Purkinje cells, heterosynaptic competition between inputs from different

20 ual cortex have been interpreted in terms of heterosynaptic competition between inputs.

21 We show that heterosynaptic competition within single neurons, when c

22 hat one set of inputs can exert long-lasting heterosynaptic control over another, allowing the coupli

23 of descending sensory control and imply that heterosynaptic cooperativity contributes to the auditory

24 In these cases of heterosynaptic cooperativity, thalamocortical efficacy d

25 Afferent Glu spillover provides heterosynaptic cross talk with GABAergic inhibition in N

26 ut theoreticians have also seen the need for heterosynaptic decreases in synaptic efficacy, both in n

27 cording has been used to study the effect of heterosynaptic depolarization on pure N-methyl-D-asparta

28 adaptation in vivo, there was no evidence of heterosynaptic depression between independent inputs in

29 tivation during cortical seizures in vivo or heterosynaptic depression in situ is independent of Nt5e

30 e touch (T) mechanosensory neurons induces a heterosynaptic depression of nociceptive (N) synapses th

31 lar GABA, which in turn caused a short-lived heterosynaptic depression of the parallel fiber to Purki

32 We speculate that this heterosynaptic depression provides the mossy fiber synap

33 terosynaptic facilitation' at -60 mV and of 'heterosynaptic depression' at +40 mV of EPSPN was simila

34 ation from 'heterosynaptic facilitation' to 'heterosynaptic depression' of EPSPN.

35 t for cerebellar transmission in vivo, since heterosynaptic depression, produced by activating GABAer

36 y of eliciting LTD accompanied by persistent heterosynaptic depression.

37 ed from interneurons contribute to 'diffuse' heterosynaptic depression.

38 otentiation and mediated activity-dependent, heterosynaptic depression.

39 Heterosynaptic ecLTD was unaffected by antagonists for N

40 Activity-dependent heterosynaptic effects acting within network cellular as

41 second input served as a control to monitor heterosynaptic effects.

42 This heterosynaptic, endocannabinoid-dependent long-term depr

43 This heterosynaptic, endocannabinoid-dependent modulation of

44 inhibitory input to PBN neurons by inducing heterosynaptic, endocannabinoid-dependent, long-term dep

45 eceptor antagonists, suggesting an indirect, heterosynaptic enhancement of GABA release caused by a V

46 vity that differentially modulates long-term heterosynaptic facilitation at the converging inputs.

47 By contrast, the heterosynaptic facilitation mediated by the modulatory t

48 at CRF-R2 may regulate glutamate release via heterosynaptic facilitation of GABA synapses.

49 ation involve multiple mechanisms, including heterosynaptic facilitation of sensory neuron-motor neur

50 hich activates Cdc42 and Rac1, but not RhoA; heterosynaptic facilitation of sLTP, which is conveyed b

51 nin-induced facilitation; this suggests that heterosynaptic facilitation primarily involves an increa

52 The heterosynaptic facilitation produced by a single pulse o

53 The time course of 'heterosynaptic facilitation' at -60 mV and of 'heterosyn

54 eterosynaptic paired-pulse stimulation from 'heterosynaptic facilitation' to 'heterosynaptic depressi

55 ation of the individually produced homo- and heterosynaptic facilitation.

56 her, the sensory neurons exhibit significant heterosynaptic facilitation.

57 mina I NK1R(+) neurons may contribute to the heterosynaptic facilitatory mechanisms underlying mechan

58 ain access to specific spinal circuitry, via heterosynaptic facilitatory mechanisms, to mediate mecha

59 This heterosynaptic form of plasticity is involved in changes

60 ons on pyramidal neurons, thereby generating heterosynaptic i-LTP in the AC.

61 This I-LTD is heterosynaptic in nature, requiring glutamate release to

62 We tested the hypothesis that heterosynaptic influences from excitatory motor axon inp

63 weakening during later development and that heterosynaptic influences from sensory synapses during e

64 utoreceptor inhibition by glutamate or GABA, heterosynaptic inhibition by GABA, tonic adenosine inhib

65 The blockade of heterosynaptic inhibition by the membrane-permeant Ca2+

66 ming stimulation of mPFC projections induced heterosynaptic inhibition in auditory cortical inputs to

67 evidence, we propose that the time course of heterosynaptic inhibition is determined primarily by the

68 Heterosynaptic inhibition of mossy fiber responses was o

69 Heterosynaptic inhibition of synaptic currents and calci

70 l and electrophysiological data suggest that heterosynaptic inhibition was enhanced by higher frequen

71 umed that the role of the strongly activated heterosynaptic input during the induction of associative

72 lasticity induced by PAS can be modulated by heterosynaptic inputs of cTBS150.

73 y associated with LTP, with LTD appearing at heterosynaptic inputs.

74 This unique type of heterosynaptic interaction is a hallmark feature of syna

75 emporal order of activation are critical for heterosynaptic interactions among convergent synaptic in

76 ergic cotransmission can provide a basis for heterosynaptic interactions between the B and C pathways

77 We found that both homosynaptic and heterosynaptic interactions increase the likelihood of d

78 elayed by homosynaptic interactions, whereas heterosynaptic interactions may help detect coincident s

79 ltage-clamp conditions (tested at +40 mV) no heterosynaptic interactions were seen.

80 two different presynaptic neurons interact (heterosynaptic interactions), and (3) what is the time c

81 red-pulse stimulation) did not result in any heterosynaptic interactions.

82 what is the time course of homosynaptic and heterosynaptic interactions?

83 Release from OSNs was strongly suppressed by heterosynaptic, intraglomerular inhibition.

84 l at mossy-fiber synapses in KA2-/- neurons, heterosynaptic kainate receptor-mediated facilitation re

85 The induction of heterosynaptic L-LTP is associative and critically depen

86 ico-hippocampal activity provides a powerful heterosynaptic learning rule for long-term gating of inf

87 at in the CA1 region of the hippocampus this heterosynaptic long-term depression has the property tha

88 However, much less is known about heterosynaptic long-term plasticity induced by mGluRs at

89 tic acetyl choline receptors account for the heterosynaptic loss in vitro.

90 Protein kinase C (PKC) mediates a heterosynaptic loss of efficacy, and we now show that pr

91 Heterosynaptic LTD can occur at synapses that are inacti

92 When the test stimulations were resumed, heterosynaptic LTD could not be observed.

93 Moreover, this dopamine-mediated heterosynaptic LTD is abolished after withdrawal from co

94 5 min) of the glutamatergic synapses induced heterosynaptic LTD of GABAergic transmission, and the LT

95 to the pathway which was silent during LFS (heterosynaptic LTD) in experiments conducted above spiki

96 term depression (LTD), and slowly developing heterosynaptic LTD, of Schaffer collateral-pyramidal cel

97 conversion of LTD to LTP and elimination of heterosynaptic LTD, whereas blocking ryanodine receptors

98 This heterosynaptic LTP may provide a dopamine-guided mechani

99 This heterosynaptic LTP may provide a dopamine-guided mechani

100 ate transmission in the VTA via a concerted, heterosynaptic manner that may become altered by stress-

101 f different forms of plasticity--Hebbian and heterosynaptic--may prevent runaway synaptic dynamics an

102 This may provide an additional heterosynaptic mechanism for controlling excitation and

103 This heterosynaptic mechanism is likely to boost the efficacy

104 affecting BLA-to-NAcSh synapses, revealing a heterosynaptic mechanism through which BLA signals persi

105 t affecting BLA-to-NAc synapses, revealing a heterosynaptic mechanism through which BLA signals poten

106 ingle-neuron model, we show that Hebbian and heterosynaptic mechanisms plausibly underlie the retenti

107 ceptors and dopamine transporters-as well as heterosynaptic mechanisms, such as retrograde signaling

108 er, we found that mossy fiber NMDARs mediate heterosynaptic metaplasticity between mossy fiber and as

109 in a way that occluded further reduction by heterosynaptic metaplasticity, whereas LTP was entirely

110 ork-connected parietal-motor circuit through heterosynaptic metaplasticity.

111 The heterosynaptic modulation interacted with short-term hom

112 neurobiological correlate of sensitization, heterosynaptic modulation of sensory neuron excitability

113 ons can be enhanced in one of two ways: by a heterosynaptic (modulatory input-dependent) mechanism th

114 Importantly, GABAergic STDP is heterosynaptic (NMDA receptor dependent): triggered by c

115 examined the reciprocal impact of short-term heterosynaptic or homosynaptic plasticity at sensorimoto

116 Mg(2+)-free medium converted the response to heterosynaptic paired-pulse stimulation from 'heterosyna

117 However, under current-clamp conditions, heterosynaptic paired-pulse stimulation resulted in hete

118 stimulation of a second set of fibres (i.e. heterosynaptic paired-pulse stimulation) did not result

119 at potentials of between -30 and +40 mV then heterosynaptic paired-pulse stimulation, in normal Mg(2+

120 ynaptic paired-pulse stimulation resulted in heterosynaptic 'paired-pulse facilitation' of the NMDA r

121 Here we describe L-LTP elicited by such heterosynaptic pairing at the Schaffer collateral synaps

122 forms of learning are likely to require the heterosynaptic pairing of stimuli.

123 We propose that when a heterosynaptic pathway has been recently used, continuou

124 tic pathway, the 0.017 Hz test pulses to the heterosynaptic pathway were interrupted for 25 min.

125 rization, is sufficient to induce LTP in the heterosynaptic pathway, whereas an enzymatic glutamate s

126 synaptic strength could also be detected in heterosynaptic pathways, indicating a global response.

127 omosynaptic depression (HSD)], or short-term heterosynaptic plasticity [serotonin-induced facilitatio

128 out (KO) mice will express (1) impairment of heterosynaptic plasticity and (2) behavioral deficits in

129 synaptic potentiation in layer 5, but induce heterosynaptic plasticity and spike output in layer 2/3.

130 Moreover, these results identify heterosynaptic plasticity as a new potential target for

131 city at paired inputs and different forms of heterosynaptic plasticity at the strongest unpaired syna

132 one increases sleep pressure), modulation of heterosynaptic plasticity by adenosine represents an end

133 behavioral consequences of the impairment of heterosynaptic plasticity by experimental manipulations

134 ations, we show that experimentally observed heterosynaptic plasticity can indeed serve the theoretic

135 nstrated that co-occurring, weight-dependent heterosynaptic plasticity can robustly prevent runaway d

136 alyses demonstrated how the relative rate of heterosynaptic plasticity could normalize and stabilize

137 hen nearby, nonsynchronous synapses by local heterosynaptic plasticity crosstalk mediated by NMDAR-de

138 We find that heterosynaptic plasticity effectively prevented runaway

139 xperimental analysis of the proposed role of heterosynaptic plasticity in behavior.

140 e blockade of adenosine A1 receptors impairs heterosynaptic plasticity in brain slices and, when impl

141 experimental evidence for a proposed role of heterosynaptic plasticity in organism-level learning.

142 Short-term heterosynaptic plasticity induced by 5-HT (facilitation)

143 We conclude that heterosynaptic plasticity is an inherent property of pla

144 ong and repeated, the magnitude of LTP after heterosynaptic plasticity is greatly increased, specific

145 Importantly, this form of heterosynaptic plasticity is induced at unpaired synapse

146 We propose that weight-dependent heterosynaptic plasticity may counteract runaway dynamic

147 and lack mechanisms for synaptic competition.Heterosynaptic plasticity may solve these problems by co

148 This subthreshold form of heterosynaptic plasticity occurs in the absence of somat

149 s, this experimentally characterized form of heterosynaptic plasticity prevents runaway dynamics of s

150 ying synaptic signalling in this new form of heterosynaptic plasticity remain unclear.

151 This new form of heterosynaptic plasticity represents the cellular basis

152 between tonic vs. phasic neurons and defines heterosynaptic plasticity rules in a powerful model glut

153 ns, such changes of the weight dependence of heterosynaptic plasticity shifted their operating point

154 s, in intercalated neurons at least, inverse heterosynaptic plasticity tends to compensate for homosy

155 . (2015) present a cortically driven form of heterosynaptic plasticity that could promote oscillatory

156 nduction of a form of dendritic spike driven heterosynaptic plasticity that enhances memory specifici

157 round firing activity, neural adaptation and heterosynaptic plasticity to a rate attractor network mo

158 This provides the first evidence linking heterosynaptic plasticity to organism-level learning.

159 weight dependence determines the ability of heterosynaptic plasticity to prevent runaway dynamics of

160 el implementing both homosynaptic (STDP) and heterosynaptic plasticity with properties matching the e

161 earning is correlated with differences in SN heterosynaptic plasticity within a background of evoluti

162 Changing the weight dependence of heterosynaptic plasticity within an experimentally obser

163 ltiple terminals and allows the emulation of heterosynaptic plasticity, an important learning rule in

164 any known aspects of experimentally observed heterosynaptic plasticity, and moreover makes new experi

165 rt-term homosynaptic plasticity to long-term heterosynaptic plasticity, and we implicate dopamine in

166 c regulation of synaptic efficacy, including heterosynaptic plasticity, gain control, output balancin

167 the disparate worlds of the neurobiology of heterosynaptic plasticity, the engineering of regularize

168 A novel, retroactive form of heterosynaptic plasticity, where activation of one group

169 a novel type of plasticity, weight-dependent heterosynaptic plasticity, which accompanies the inducti

170 etical and modeling studies demonstrate that heterosynaptic plasticity-changes at synapses inactive d

171 pses on inhibitory neurons, weight-dependent heterosynaptic plasticity.

172 ces of the impairment of Hebbian-type versus heterosynaptic plasticity.

173 anipulation prevented behavioral analysis of heterosynaptic plasticity.

174 ritic democracy, multiplicative scaling, and heterosynaptic plasticity.

175 and to generate a temporally precise form of heterosynaptic plasticity.

176 accompanied by changes in unpaired synapses: heterosynaptic plasticity.

177 es hippocampus-amygdala interactions to gate heterosynaptic plasticity.

178 aptically active during the induction, i.e., heterosynaptic plasticity.

179 detection that gives rise to a novel form of heterosynaptic plasticity.

180 hat adenosine regulates weight dependence of heterosynaptic plasticity: adenosine strengthened weight

181 adenosine modulates the weight dependence of heterosynaptic plasticity: blockade of adenosine A1 rece

182 adenosine strengthened weight dependence of heterosynaptic plasticity; blockade of adenosine A1 rece

183 methyl ester (L-NAME), completely prevented heterosynaptic potentiation and associated reduction in

184 Thus, CA1 neurons expressing heterosynaptic potentiation induced by external sensory

185 results are consistent with the notion that heterosynaptic potentiation is of pre-synaptic origin an

186 linergic axons is thus sufficient to trigger heterosynaptic potentiation of glutamatergic signalling

187 on of apical tuft synapses alone resulted in heterosynaptic potentiation of proximal synapses.

188 Our studies reveal a mechanistically unique heterosynaptic PP1 gate that is constitutively driven by

189 aminobutyric acid (GABA) act as autaptic and heterosynaptic presynaptic inhibitory transmitters throu

190 a larger quantal size, whereas autaptic and heterosynaptic PV-PV synapses differed in the number of

191 sensitization, became labile with short-term heterosynaptic reactivation and reversed when the reacti

192 e of PKC activity or a homosynaptic, but not heterosynaptic, reactivation when paired with rapamycin.

193 ese inputs and determine their intrinsic and heterosynaptic relationships.

194 This novel form of LTP is heterosynaptic, requiring postsynaptic NMDA (N-methyl-d-

195 at the first central synapses, suggesting a heterosynaptic role for the Group II mGluRs in shaping b

196 The molecular mechanism for heterosynaptic sharing involves metabotropic glutamate r

197 Heterosynaptic sharing is blocked by postsynaptic disrup

198 This heterosynaptic sharing of plasticity represents a dynami

199 ial thereby altering homosynaptic as well as heterosynaptic short-term ionic plasticity at GABAergic

200 The induction of LTD at homo- and heterosynaptic sites requires functional ryanodine recep

201 Such heterosynaptic spread of synaptic facilitation could acc

202 e homosynaptic pathway was involved, with no heterosynaptic stimulation, as in conventional experimen

203 comes labile following selective activations-heterosynaptic stimuli that evoke opposite forms of plas

204 to 0.033 Hz) during a 25 min interruption of heterosynaptic stimulus did not preserve homosynaptic LT

205 elective silencing by BoNT-C does not induce heterosynaptic structural or functional plasticity at th

206 contribution of KOR signaling in PFC-driven heterosynaptic suppression of HP inputs onto MSNs using

207 resulted in complete blockade of PFC-induced heterosynaptic suppression of less salient HP inputs.

208 triggers the release of endocannabinoids and heterosynaptic suppression of PF inputs.

209 BLA train stimulation also produced heterosynaptic suppression of responses from the amygdal

210 Heterosynaptic suppression was unidirectional as HP trai

211 eads to what we call spatial competition, or heterosynaptic synaptic modification.

212 ere the first well-defined mechanism for the heterosynaptic transmitter-mediated regulation of transm