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2 aryl hydrocarbon receptor (AhR) exists in a heterotetrameric 9S core complex consisting of the AhR l
4 GIRK1 and GIRK4 subunits combine to form the heterotetrameric acetylcholine-activated potassium curre
5 of overlapping hot spots of dynamin and the heterotetrameric adaptor 2 complex in Drosophila nerve t
7 with distinct endocytic adaptors such as the heterotetrameric adaptor AP3 influence the trafficking o
9 Expression of the epithelial cell-specific heterotetrameric adaptor complex AP-1B is required for t
11 is a chaperone governing the assembly of the heterotetrameric adaptor complexes 1 and 2 (AP1 and AP2)
14 targeting and are recognized by a family of heterotetrameric adaptor complexes, which then recruit c
18 t well-characterized member of the family of heterotetrameric adaptor protein (AP) complexes that med
22 AP1B1, the gene encoding the beta subunit of heterotetrameric adaptor protein 1 (AP-1) complexes, whi
25 of genes, including several subunits of the heterotetrameric adaptor protein AP-3, which are require
26 g and vesiculation process that requires the heterotetrameric adaptor protein AP3 and a small molecul
29 that hVPS41 requires both a functional AP-3 (heterotetrameric adaptor protein complex) and HOPS (homo
37 itment onto membranes are not dependent upon heterotetrameric adaptors or AP180 homologs in yeast.
40 , Cep63 and Cep152, cooperatively generate a heterotetrameric alpha-helical bundle that functions in
41 sferase (E2) decorated with 60 copies of the heterotetrameric (alpha(2)beta(2)) 153-kDa pyruvate deca
42 lution temperatures (28 to ~40 degrees C), a heterotetrameric (alpha(2)beta(2)) complex is the most a
44 acid decarboxylase/dehydrogenase (BCKD) is a heterotetrameric (alpha(2)beta(2)) thiamine diphosphate
45 nt of subunits closely resembles that of the heterotetrameric (alphabeta)(2) phenylalanyl-tRNA synthe
48 coccus furiosus contains an NADPH-utilizing, heterotetrameric (alphabetagammadelta), cytoplasmic hydr
49 homotetrameric recombinant GluR2, the native heterotetrameric AMPA-R adopted various conformations, w
51 motility and ATP hydrolysis of recombinant, heterotetrameric and homodimeric conventional Drosophila
52 Sera of camelids contain both conventional heterotetrameric antibodies and unique functional heavy
54 iae, there are 13 genes encoding homologs of heterotetrameric AP subunits and two genes encoding AP18
57 AP-4, a novel protein complex related to the heterotetrameric AP-1, AP-2, and AP-3 adaptors that medi
59 in 1, the so-called DPW domain, binds to the heterotetrameric AP-2 adaptor complex by associating dir
66 l that clathrin function is dependent on the heterotetrameric APs and/or AP180 homologs, yeast strain
71 the so-called 'hinge' region of MukB forms a heterotetrameric assembly with a C-terminal DNA binding
75 nd dynamics of plasma membrane OAPs, and the heterotetrameric associations of AQP4, we constructed gr
79 In this study we identify calpactin I, a heterotetrameric, Ca(2+)- and phospholipid-binding prote
83 wild-type subunits to maintain a functional heterotetrameric channel differed among the four RyR1 mu
88 P3R monomers are assembled to form homo- and heterotetrameric channels that mediate Ca(2+) release fr
89 Coexpression of WT+T421M-Kv11.1 resulted in heterotetrameric channels that remained partially traffi
91 splicing in the alpha subunit, formation of heterotetrameric channels, and combinatorial association
94 s the possibility of interaction between the heterotetrameric chromogranin and heterotetrameric IP3 r
95 analysis and mutagenesis studies reveal that heterotetrameric ChsE1-ChsE2 has only two active sites.
98 es containing either homotetrameric (CNGA2), heterotetrameric (CNGA2:CNGA4:CNGB1b), or hyperpolarizat
99 ransglutaminase is the catalytic part of the heterotetrameric coagulation FXIII-A(2)B(2) complex that
101 Lateral association seems to be mediated by heterotetrameric coiled coils between the paired C-termi
105 catalyzing intron removal from pre-tRNA is a heterotetrameric complex (splicing endonuclease [SEN] co
106 ts of this CC MBS.LZ PKG-Ialpha low-affinity heterotetrameric complex and allow reevaluation of the r
107 tructure of a protocadherin-15 + cadherin-23 heterotetrameric complex at 2.9- angstrom resolution, de
109 ystal structure and mutational analysis of a heterotetrameric complex between constitutively active R
110 two homodimers assemble into a high-affinity heterotetrameric complex by virtue of two low-affinity i
111 act in vivo and are predicted to form a core heterotetrameric complex capable of creating higher orde
114 35 are homologous P-loop NTPases that form a heterotetrameric complex essential for FeS protein matur
115 modeling of the dimer-dimer interface of the heterotetrameric complex exhibits the involvement of non
118 2)-sFlaF(2) co-crystal structure, define its heterotetrameric complex in solution by small-angle X-ra
119 UB1) and its paralog HUB2 act in a conserved heterotetrameric complex in the chromatin-mediated trans
120 C-1-P-directed invasion, indicating that the heterotetrameric complex is required for C-1-P-mediated
121 We also analyzed binding parameters of a heterotetrameric complex of AnxA2 with its S100A10 prote
123 isoforms initiate signaling by assembling a heterotetrameric complex of paired type I (TbetaRI) and
124 nvolving only 50S subunits and mediated by a heterotetrameric complex of PurH and aEF2-proteins with
129 Analysis of the reconstituted Rad3-Rad26 heterotetrameric complex with electron microscopy enable
130 iption without directly binding DNA but as a heterotetrameric complex with ETS1, a transcription fact
131 tein core domain and for AnxA2 residing in a heterotetrameric complex with its intracellular binding
135 on is believed to derive from formation of a heterotetrameric complex with target proteases involving
137 he hypothesis that the "normal" state in the heterotetrameric complex, in which XerC is catalytically
138 molecular and functional insights into this heterotetrameric complex, we computationally constructed
148 Cu2+ to facilitate the formation of S100A13 heterotetrameric complexes and these signal peptideless
149 ity, the composition and expression of these heterotetrameric complexes are expected to be tightly re
150 that native channels can be either homo- or heterotetrameric complexes composed of several GIRK subu
152 show that Kv1 channels assembled as homo- or heterotetrameric complexes had distinct surface expressi
153 athrin-associated adaptors AP-1 and AP-2 are heterotetrameric complexes involved in the recognition o
155 branes in a distinctive manner by assembling heterotetrameric complexes of structurally related serin
156 ociated recycling protein (EARP) are related heterotetrameric complexes that associate with the cytos
158 uitously expressed, evolutionarily conserved heterotetrameric complexes that mediate different types
159 tly expressed in the brain where it can form heterotetrameric complexes with TRPC1 and TRPC4 channel
165 Kv2/KvS assembly increases the diversity of heterotetrameric configurations and extends the regulato
166 , the biological properties of the different heterotetrameric configurations formed by PIP1 and PIP2
167 ion (GAIT) complex in human myeloid cells is heterotetrameric, consisting of glutamyl-prolyl-tRNA syn
169 in Alzheimer disease (AD) and consists of a heterotetrameric core complex that includes the aspartyl
170 as a heterotetramer, resembling the (H3/H4)2 heterotetrameric core of the histone octamer, suggesting
171 al complex consisting of a (Mre11)2/(Rad50)2 heterotetrameric DNA processing head and a double coiled
173 dues in the E1alpha and E1beta chains of the heterotetrameric E1 (alpha(2)beta(2)) component of the P
174 ears to be conserved in the alpha-subunit of heterotetrameric E1s and multiple sequence alignments su
176 a single subunit type, the plant AGPase is a heterotetrameric enzyme (alpha2beta2) with distinct role
177 ne oxidase from Corynebacterium sp. P-1 is a heterotetrameric enzyme (alphabetagammadelta) that conta
179 and small (SS) subunits yielded a functional heterotetrameric enzyme capable of complementing a mutat
180 ant ADP-glucose pyrophosphorylase (AGP) is a heterotetrameric enzyme composed of two large and two sm
181 e relative roles of the conserved Lys in the heterotetrameric enzyme from potato (Solanum tuberosum L
182 Protein kinase CK2 (casein kinase II) is a heterotetrameric enzyme implicated in many essential reg
183 ructure of molybdopterin synthase revealed a heterotetrameric enzyme in which the C terminus of each
184 d with SS and that the net properties of the heterotetrameric enzyme is a product of subunit synergy.
186 Pyrococcus furiosus is an NADP(H)-dependent heterotetrameric enzyme that contains a nickel-iron cata
187 for NAD could be measured with the purified heterotetrameric enzyme that possessed just 16-18% activ
191 cter sp. and Pseudomonas sp. show that these heterotetrameric enzymes also contain covalently bound F
192 AP4E1 encodes the epsilon subunit of the heterotetrameric (epsilon-beta4-mu4-sigma4) AP-4 complex
196 ome bacteria, archaea, and eukaryotes; and a heterotetrameric form (alpha2beta2) present in most bact
197 lder interface conferred specificity for the heterotetrameric form and the trans-orientation of subun
199 of the Pol2p.Dpb2p complexes reveals a novel heterotetrameric form, consisting of two heterodimers of
200 est that molecular association of IP3Rs into heterotetrameric forms can contribute to the complexity
202 for this diversity, we designed an A(2)B(2) heterotetrameric four-helix bundle with an active site s
203 heterooctomeric ATP-sensitive K channels and heterotetrameric G-protein-regulated inward rectifier K
206 tRNA synthetase (EPRS) is a component of the heterotetrameric gamma-interferon-activated inhibitor of
207 (gamma-TuC), in which multiple copies of the heterotetrameric gamma-tubulin small complex (gamma-TuSC
208 handover of TA substrates is mediated by the heterotetrameric Get4/Get5 complex (Get4/5), which tethe
209 led homotetrameric GIRK1 channels and in the heterotetrameric GIRK1/2 channel, the truncation of G1-d
211 ma alone activated homotetrameric GIRK1* and heterotetrameric GIRK1/3 channels, without affecting the
212 we show the crystal structure of the intact heterotetrameric GluN1-GluN2B NMDA receptor ion channel
214 he mature insulin receptor is a cell surface heterotetrameric glycoprotein composed of two alpha- and
219 that encode monomeric forms of the normally heterotetrameric insulin receptor and monomeric platelet
220 nstituted receptor shows the alpha(2)beta(2) heterotetrameric insulin receptor to be a three-armed pi
221 SP8 assembly, and interface II mediating the heterotetrameric interaction between the two NSP7-NSP8 d
224 N-methyl-d-aspartate receptors (NMDARs) are heterotetrameric ion channels assembled as diheteromeric
225 etween the heterotetrameric chromogranin and heterotetrameric IP3 receptor but also appears to reflec
226 hosphate (IP3) receptor and the existence of heterotetrameric IP3 receptor in the cell, the heterotet
230 B/LDHA expression analysis intimated various heterotetrameric isoforms comprising LDHA and LDHB in tu
231 omains bound to two JAK2 molecules, creating heterotetrameric JAK2-(SH2-B)2-JAK2 or JAK2-(APS)2-JAK2
232 ata were compared with [125I]MgTX binding to heterotetrameric K(V) channels in rat brain synaptic pla
236 yl-D-aspartate (NMDA) receptors are obligate heterotetrameric ligand-gated ion channels that play cri
240 ependent isocitrate dehydrogenase (IDH) is a heterotetrameric mitochondrial enzyme with 2alpha:1beta:
242 etween individual domains of E1p relative to heterotetrameric multienzyme complex E1 components opera
244 and antibody labeling, demonstrates that the heterotetrameric Ndc80 complex is an approximately 570-A
245 of pore-forming transmembrane helices in the heterotetrameric neuronal channel GluN1a-2B N-methyl-D-a
246 Membrane-associated Hyd-2 is an unusual heterotetrameric [NiFe]-hydrogenase that lacks a typical
247 t dimer dissociation is critical for forming heterotetrameric NMDA-Rs containing GluN2 subunits, defi
248 ive AdoCbl-dependent PCM with an alpha2beta2 heterotetrameric organization similar to that of isobuty
250 primer strand through the dual action of the heterotetrameric polymerase alpha-primase (pol-prim) enz
252 sidue in the large and small subunits of the heterotetrameric potato (Solanum tuberosum) tuber enzyme
253 factor XIII (FXIII) exists in circulation as heterotetrameric proenzyme FXIII-A2B2 Effectively all FX
254 t complex (b([0,+])AT1-rBAT) which reveals a heterotetrameric protein assembly composed of two heavy
255 ed by actin-capping protein at one end and a heterotetrameric protein complex containing the p62 subu
257 showed that the X. sagittifolium lectin is a heterotetrameric protein composed of four 12-kDa subunit
258 ne oxidase from Corynebacterium sp. P-1 is a heterotetrameric protein containing three different enzy
261 hetase (PheRS) is a multidomain (alphabeta)2 heterotetrameric protein responsible for synthesizing Ph
262 ing through the extracellular annexin a2-p11 heterotetrameric protein, can mediate vascular endotheli
265 rent TGFbeta isoforms induce assembly of the heterotetrameric receptor complex in the same general ma
266 or (GDNF) is a ligand for RET and acts via a heterotetrameric receptor complex that includes GDNF rec
267 he insulin receptor, the IGF-1 receptor is a heterotetrameric receptor tyrosine kinase, whereas the I
273 synthase (GltB2), large subunit of putative heterotetrameric sarcosine oxidase (SoxA) and glutamine
281 s dimerization to initially form an inactive heterotetrameric species, followed by conversion to acti
282 -containing tRNAs requires the action of the heterotetrameric splicing endonuclease, which is compose
283 nken2 (Sh2) encodes the large subunit of the heterotetrameric starch synthetic enzyme adenosine dipho
284 nomic locations suggest that the alpha2beta2 heterotetrameric structural motif has evolved to enable
287 In the bacterial GA crystals, we observe a heterotetrameric structure similar to that found in the
288 two MoaE subunits and two MoaD subunits in a heterotetrameric structure with the two MoaE subunits fo
289 y that different TRPC subunits coassemble as heterotetrameric structures to form smooth muscle SOCs.
290 core proteins form homotetrameric (Red1) or heterotetrameric (SYCP2:SYCP3 and ASY3:ASY4) coiled-coil
292 e mammalian immune response is mediated by a heterotetrameric transcriptional control complex, called
293 cells and identify a regulatory role for the heterotetrameric translocon-associated protein (TRAP) co
294 ked SSR4 gene which encodes a protein of the heterotetrameric translocon-associated protein (TRAP) co
295 smooth muscle results from the formation of heterotetrameric TRPC structures in different smooth mus
296 l and adult homeostatic events through their heterotetrameric type I and type II receptor complexes.
299 sarcoglycan complex in striated muscle is a heterotetrameric unit integrally associated with sarcosp
300 lution are required for the formation of the heterotetrameric Vestigial-Scalloped complex on DNA.