ライフサイエンスコーパス: heterotopic

1 The authors developed a model of heterotopic abdominal heart transplant (HAHT) to investi

2 UN was induced in male Lewis rat hearts by heterotopic abdominal heart transplantation.

3 Heterotopic abdominal rat heart transplantation has been

4 of cardiac allograft vasculopathy (CAV) is a heterotopic (abdominal) vascularized murine cardiac tran

5 Heterotopic, abdominal transplantation of cardiac allogr

6 -1 protein expression is increased in murine heterotopic airway rejection, and deficiency of HO-1 acc

7 d myofibroblast infiltration was observed in heterotopic airways transplanted into the IL-13(-/-) rec

8 Recipients of heterotopic allogeneic cardiac grafts (C3H donors into B

9 0 mug of TNFRSF25 agonist 4C12 4 days before heterotopic allogeneic heart transplantation.

10 onary IL-10 gene transfer using a functional heterotopic allograft heart transplant model in rabbits.

11 We report significant prolongation of heterotopic alpha Galactosyl transferase "knock-out" and

12 Heterotopic and control (orthotopic) transplants consist

13 antly higher than that between nonhomotopic (heterotopic and intrahemispheric) regions.

14 Using heterotopic and intravenous injection models of lung met

15 irect xenograft tumors require 2 and 5 h for heterotopic and orthotopic implantation, respectively, a

16 In vivo heterotopic and orthotopic implantations using ESRP1 ove

17 The growth of heterotopic and orthotopic Met-expressing human tumor xe

18 In mice with established heterotopic and orthotopic pancreatic tumor xenografts,

19 murine Lewis lung cancer (LLC; 3LL, H-2(b)) heterotopic and orthotopic tumor model systems in C57BL/

20 stained increase in Gd concentration in both heterotopic and orthotopic tumors using dynamic quantita

21 significant decrease in tumor growth in both heterotopic and orthotopic, including patient-derived xe

22 e-controlled NEVKP (n = 5) followed by renal heterotopic autotransplantation.

23 Heterotopic B.16-F10 melanomas elicited greater vascular

24 C57Bl/6 B7-1/B7-2-/- mice were grafted with heterotopic BALB/c hearts.

25 eir migration in the white matter, forming a heterotopic band below the normotopic cortex, and is gen

26 illatory activity is less synchronous across heterotopic bands and mutants are less responsive to pha

27 mine the fibroproliferative tissue preceding heterotopic bone and identified pathologic stiffening at

28 Qualitative analysis of heterotopic bone composition was completed with ex vivo

29 ly, conditional deletion of Zfp521 inhibited heterotopic bone formation in response to local injectio

30 Heterotopic bone formation in these animals appears to f

31 Understanding the role of burn injury on heterotopic bone formation is an important first step to

32 iation is not fully understood, we adapted a heterotopic bone formation model as a new approach for s

33 seful in investigations of the mechanisms of heterotopic bone formation.

34 soaked beads in head explants also prevented heterotopic bone formation.

35 of stem cells to chondrocytes and subsequent heterotopic bone formation.

36 sease characterized by progressive postnatal heterotopic bone formation.

37 es aimed to prevent unwanted and detrimental heterotopic bone formation.

38 model to study the effect of burn injury on heterotopic bone formation.

39 se findings suggest the residence of HSCs in heterotopic bone marrow and support the future use of th

40 tem cells), capable of generating a complete heterotopic bone organ upon in vivo transplantation were

41 Heterotopic bone volume was analyzed in vivo by micro-co

42 Subcutaneously implanted ossicles formed heterotopic bone.

43 To elucidate the role of NO in this cascade, heterotopic bronchial allografts were studied in pigs.

44 Heterotopic bronchus transplantation was performed in 33

45 Heterotopic brown Norway rat cardiac isografts were remo

46 Heterotopic Brown Norway-Lewis heart transplantations we

47 complex mismatch, as well as using a murine heterotopic cardiac allograft model (BALB/c->C57BL/6).

48 rejection, we developed a mouse vascularized heterotopic cardiac allograft model in which B6.RAG1 KO

49 graft rejection in a murine nonvascularized heterotopic cardiac allograft model.

50 Heterotopic cardiac allograft outcomes in cynomolgus mon

51 Cynomolgus monkey heterotopic cardiac allograft recipients were treated wi

52 tolerant + anti-ER-TR7 mice received BALB/c heterotopic cardiac allografts and graft survival was mo

53 ory CD4 T cells prolonged survival of murine heterotopic cardiac allografts and synergizes with conve

54 rtment, these B6 mice were transplanted with heterotopic cardiac allografts from allogeneic BALB/c do

55 ansferred into immune-deficient mice bearing heterotopic cardiac allografts from IFN-gamma receptor-d

56 Survival of Lewis to Fisher 344 rat heterotopic cardiac allografts was determined in untreat

57 mune profiles and transplanted chimeras with heterotopic cardiac allografts with or without costimula

58 the graft in cynomolgus monkey recipients of heterotopic cardiac allografts.

59 In a heterotopic cardiac allotransplantation model, CD73 defi

60 We used a murine heterotopic cardiac transplant model to identify inflamm

61 A vascularized murine heterotopic cardiac transplant model was used to test wh

62 e report the management of an infant who had heterotopic cardiac transplantation for advanced cardiom

63 shows several issues relating to the use of heterotopic cardiac transplantation in infants and the c

64 Heterotopic cardiac transplantation in the intra-abdomin

65 The mouse heterotopic cardiac transplantation model has been used

66 A murine heterotopic cardiac transplantation model was used to te

67 o smoke exposure in 6 groups of animals (rat heterotopic cardiac transplantation) as follows: tobacco

68 to control fibers, 10-hr heart cold storage, heterotopic cardiac transplantation, and 24-hr reperfusi

69 -mediated cardioprotection in a rat model of heterotopic cardiac transplantation.

70 At age 11 months, the patient underwent a heterotopic cardiac transplantation.

71 ance to cardiac allografts in large animals, heterotopic cardiac transplants were performed across a

72 6) of previous transgenic CD46 pig-to-baboon heterotopic cardiac transplants were reanalyzed for base

73 Eight baboons received heterotopic cardiac xenografts from GalT-KO porcine dono

74 Heterotopic cardiac xenotransplantation from alpha1,3-ga

75 ckout cardiac xenografts after pig-to-baboon heterotopic cardiac xenotransplantation when the induced

76 ckout (GTKO) background using pig-to-primate heterotopic cardiac xenotransplantation.

77 Heterotopic cartilage develops in certain pathologic con

78 By 6 mo, heterotopic cartilage had formed in the discs and expres

79 GAT-3) revealed a low level of expression in heterotopic cell regions, suggesting a reduced ability f

80 Finally, heterotopic cellular aggregates invade the Ctip2-/- stri

81 uated the tumor binding in nude mice bearing heterotopic cervical (HT3), esophageal (OE33), pancreati

82 G peptide was evaluated in nude mice bearing heterotopic cervical (HT3), esophageal (OE33), pancreati

83 METHODS AND Five dogs underwent heterotopic cervical heart transplantation and simultane

84 Here we show that heterochronic and heterotopic changes early in limb development contribute

85 Previous studies have shown that heterotopic clusters of neocortically derived neurons ex

86 dynamic FC across both intrahemispheric and heterotopic connections.

87 compared with other interhemispheric (i.e., heterotopic) connections.

88 e transfer into B6 recipients 2 weeks before heterotopic DBA/2J heart transplantation resulted in pro

89 Heterotopic donor C57BL/6 cardiac allografts were perfor

90 rafts could induce and maintain tolerance of heterotopic donor-matched hearts through pathways that w

91 However, at some sites, we also observed heterotopic effects; deactivating a specific domain in M

92 longer had any effect on them although the 'heterotopic' effects on a muscle not involved in the int

93 'Heterotopic' effects on a muscle not vibrated during the

94 g opposite effects on neighbouring muscles ('heterotopic' effects).

95 n adipocytes, which drive the early steps of heterotopic endochondral ossification by lowering oxygen

96 new members of the globin family and display heterotopic expression patterns.

97 ling and causes the rare genetic disorder of heterotopic (extraskeletal) bone formation fibrodysplasi

98 itrate (GN) was used to induce acceptance of heterotopic FVB/N (H-2(q)) heart allografts by C57BL/6 (

99 iled studies revealed that the mechanisms of heterotopic gene expression in Plg(o) mice required fibr

100 Furthermore, by heterotopic grafting, we show that neural crest cell pop

101 Heterotopic grafts also gave rise to many ectopic muscle

102 arts were transplanted as fully vascularized heterotopic grafts from BALB/c donors into C57BL/6 recip

103 terior chamber of BALB/c eyes protects these heterotopic grafts from rejection but has only a trivial

104 Furthermore, heterotopic grafts of cells from outside the border to t

105 ouble cortex," a brain malformation in which heterotopic gray matter is interposed between zones of w

106 The commonest location of heterotopic gray matter were fronto-parietal areas of br

107 cal regions with connectivity to subcortical heterotopic gray matter.

108 A new rat model of heterotopic heart and lung transplantation has been deve

109 second transplant, consisting of a cervical heterotopic heart from the same ACI donor strain.

110 Heterotopic heart grafting was performed with or without

111 diated before receiving skin or vascularized heterotopic heart grafts from C57Bl/6 mice.

112 >100 day median survival of fully allogeneic heterotopic heart grafts.

113 In the murine heterotopic heart transplant model, BMS-345541 did not p

114 protocol using a rabbit functional cervical heterotopic heart transplant model.

115 assessed in a murine abdominal vascularized heterotopic heart transplant model.

116 major histocompatibility complex-mismatched heterotopic heart transplantation (BALB/c to C57BL/6) wa

117 examined in a fully allogeneic LEW to BN rat heterotopic heart transplantation (HHTx) model.

118 rse aortic constriction (TAC) prior to MU by heterotopic heart transplantation (hHTx/MU).

119 croRNA expression was examined in a model of heterotopic heart transplantation by microarray analyses

120 Heterotopic heart transplantation from GalT-KO pigs was

121 ngation was observed in a fully vascularized heterotopic heart transplantation model (DBA/2 into B6),

122 A rabbit functional cervical heterotopic heart transplantation model was used, and pl

123 ymosin beta4 attenuated graft rejection in a heterotopic heart transplantation model.

124 cultures were adoptively transferred before heterotopic heart transplantation to assess allograft su

125 ing and reduction in LV mass were induced by heterotopic heart transplantation to the abdominal aorta

126 In vivo abdominal heterotopic heart transplantation was performed in rats

127 Heterotopic heart transplantation was performed using AC

128 ith the use of an experimental rodent model, heterotopic heart transplantation was performed, creatin

129 tion Wistar Furth [RT1u] into Lewis [RT1l]), heterotopic heart transplantation was performed, creatin

130 Orthotopic kidney and heterotopic heart transplantation were performed in diff

131 es were transferred to nude mice followed by heterotopic heart transplantation.

132 y subcutaneously to rats starting the day of heterotopic heart transplantation.

133 aive animals and from mice stimulated by rat heterotopic heart transplantation.

134 A series of 10 heterotopic heart transplants from CD46 transgenic pigs

135 lloproteinases in kidneys from recipients of heterotopic heart transplants treated with CsA for 30 an

136 Heterotopic heart transplants were performed on donor he

137 Twenty-three consecutive abdominal heterotopic heart transplants were studied.

138 in glucocorticoid-treated animals following heterotopic (hepatic) expression of both carboxylated an

139 We investigated heterotopic hepatocyte transplantation on biodegradable

140 surgical techniques for orthotopic (ORT) and heterotopic (HET) hind limb transplantation.

141 n 28 NOD.rag(-/-)gammac(-/-) mice undergoing heterotopic human bronchus transplantation and reconstit

142 Orthotopic or heterotopic implantation of established cell lines requi

143 escribe our protocols for the orthotopic and heterotopic implantation of pancreatic cancer cell lines

144 Heterotopic implantation of rBELs into pigs in the absen

145 V) promotor to porcine donor hearts prior to heterotopic implantation.

146 The Imc conveys heterotopic inhibition to the TeO, Ipc, and SLu via wide

147 cal function regulating homotopic as well as heterotopic interhemispheric interactions (IHIs) are ass

148 Seven MGH-miniature swine received heterotopic intestinal grafts, two across MHC-matched, m

149 Mouse heterotopic isograft heart transplants were performed in

150 A heterotopic kidney engraftment site was used for compari

151 mononuclear cells or bone marrow cells and a heterotopic limb transplant were performed.

152 ex topologies are attainable with irregular, heterotopic linkers.

153 ormality in dentate granule cells, including heterotopic localization of granule cells in the molecul

154 Heterotopic lower layer replacement operations strongly

155 hat can occur are pancreatic saponification, heterotopic mesenteric ossification, and pseudolipoma of

156 We performed heterotopic MHC class I/II cardiac transplants from BALB

157 several days of injury, indicative of acute heterotopic mineralization along the cortical surface.

158 yosin (CM) in Freund's adjuvant and received heterotopic, minor antigen-mismatched heart transplants.

159 del (miniature swine) is feasible using this heterotopic model, and it can be useful for the study of

160 We found that in a fully mismatched heterotopic mouse heart transplantation model, T cells d

161 be targeted to any irregularities within the heterotopic mucosa.

162 The preservation and transplantation of heterotopic murine cardiac allografts strongly induce Eg

163 We performed heterotopic murine cardiac transplants in total allogene

164 gle human leukocyte antigen (HLA)-mismatched heterotopic murine heart transplant model (HLA-A2 into H

165 To that end, heterotopic murine Lewis lung cancer and tail vein metas

166 ative airways disease (OAD) also develops in heterotopic murine tracheal allografts in association wi

167 In this study, we used an heterotopic murine tracheal transplantation model to det

168 Heterotopic neurons were identified in subcortical white

169 ramatic prolongation of GABAergic IPSCs onto heterotopic neurons.

170 s (or normotopic cells) but had no effect on heterotopic neurons.

171 ortex as well as a second band of misplaced (heterotopic) neurons beneath the cortex ("double cortex

172 The mice exhibited white matter heterotopic nodules and discrete cortical tuber-like les

173 urons were classified as Type I-inhibited by heterotopic noxious conditioning stimuli (HNCS) or as Ty

174 to change and therefore was more stable than heterotopic or intrahemispheric connections.

175 The many heterotopic origins represent unexpected commissural inf

176 scaffolds in nude mice gave rise to perfect heterotopic ossicles in vivo with ultrastructure of dent

177 bers and 11% to 20% of civilians who develop heterotopic ossification (HO) after blast-related extrem

178 Heterotopic ossification (HO) and fatty infiltration (FI

179 ia (POH) is a rare developmental disorder of heterotopic ossification (HO) caused by heterozygous ina

180 Heterotopic ossification (HO) is an aberrant regenerativ

181 , and over-exuberant osteogenesis results in heterotopic ossification (HO) of soft tissues.

182 Here we use a mouse model of trauma-induced heterotopic ossification (HO) to examine how cell-extrin

183 Pathologic extraskeletal bone formation, or heterotopic ossification (HO), occurs following mechanic

184 Heterotopic ossification (HO), or the abnormal formation

185 Heterotopic ossification (HO), the abnormal formation of

186 al admission according to risk of developing heterotopic ossification (HO).

187 mine the contribution of lymphatic tissue to heterotopic ossification (HO).

188 a disabling genetic disorder of progressive heterotopic ossification (HO).

189 cer, may possibly be repurposed for treating heterotopic ossification and other diseases caused by GN

190 udy the role of the BMP signaling pathway in heterotopic ossification and to improve our understandin

191 Heterotopic ossification consisting of mature lamellar b

192 Heterotopic ossification consists of ectopic bone format

193 essiva (FOP), a debilitating and progressive heterotopic ossification disease caused by activating mu

194 Heterotopic ossification frequently occurs following inj

195 Occasional reports of mild heterotopic ossification in Albright's hereditary osteod

196 ective against injury-induced and congenital heterotopic ossification in humans.

197 Lineage tracing of heterotopic ossification in mice using a Tie2-Cre constr

198 iption in cells and disrupted caALK2-induced heterotopic ossification in mice.

199 RAR-gamma agonists are potent inhibitors of heterotopic ossification in mouse models and, thus, may

200 In addition, an RAR-gamma agonist blocked heterotopic ossification in transgenic mice expressing a

201 ation of muscle architecture adjacent to the heterotopic ossification lesion, suggesting that RARgamm

202 ficans progressiva (FOP), a disease in which heterotopic ossification occurs as a result of activatin

203 ldhood, followed by disabling and widespread heterotopic ossification of skeletal muscle and deep con

204 2, which lead to inappropriate signaling and heterotopic ossification of soft tissues.

205 Heterotopic ossification or postoperative osteolysis was

206 tients with AHO who had atypically extensive heterotopic ossification suggested a common genetic basi

207 Acvr1(R206H/+) mouse model of injury-induced heterotopic ossification to examine the fibroproliferati

208 Here we show that heterotopic ossification was essentially prevented in mi

209 cid receptor gamma (RARgamma) agonist blocks heterotopic ossification, a pathological bone formation

210 to inhibit constitutive BMP signaling during heterotopic ossification, may be re-purposed for OA trea

211 The factors contributing to heterotopic ossification, the formation of bone in abnor

212 Heterotopic ossification, the pathologic formation of ex

213 c Hedgehog signaling is sufficient to induce heterotopic ossification, whereas inhibition of this sig

214 that multiple cell sources contribute to the heterotopic ossification.

215 precluded bone union, and resulted in robust heterotopic ossification.

216 of fracture repair and substantially limited heterotopic ossification.

217 ogressiva is a rare genetic disease in which heterotopic ossifications appear in early childhood and

218 t a case of a 31-year-old woman with massive heterotopic ossifications who suffered multiple injuries

219 Associated with the heterotopic osteogenesis is an upregulation of Bmp signa

220 ibition of MSC lineage commitment may reduce heterotopic osteogenic differentiation within the injure

221 Heterotopic osteomyocutaneous flap transplantation was p

222 diation (TBI) followed by transplantation of heterotopic osteomyocutaneous flaps from hindlimbs of Au

223 ntigens by skin transplantation and received heterotopic osteomyocutaneous VCTA flaps.

224 An isolated heterotopic pancreas as a cause of bowel intussusception

225 Heterotopic pancreas is a rare developmental anomaly def

226 Though a rare entity, heterotopic pancreas should be considered in the differe

227 xamination confirmed the excised lesion as a heterotopic pancreatic tissue.

228 ograft biopsies from nonhuman primates after heterotopic partial facial segment allotransplantation f

229 rogenital tissue transplants using a new rat heterotopic penile transplant model that includes preput

230 Syngeneic and allogeneic heterotopic penile transplantations were performed on Le

231 velopment in immune-deficient mice receiving heterotopic porcine bronchus transplants, and major hist

232 median survival of 76 days in this group of heterotopic porcine-to-baboon cardiac xenografts represe

233 nterogradely labeled terminals, suggesting a heterotopic projection from Imc upon TeO.

234 Heterotopic projections (>1 mm beyond the main homotopic

235 mally positioned (normotopic) and misplaced (heterotopic) pyramidal neurons in the tish neocortex exh

236 This, and data from heterotopic quail-chick grafting studies, suggests that

237 poptosis, experiments were performed using a heterotopic rat abdominal heart transplant model and cyt

238 METHODS AND Using heterotopic rat cardiac transplantation, we tested the e

239 The heterotopic rat trachea transplant model was used.

240 evelopment, we have investigated evidence of heterotopic (relative changes in position) and heterochr

241 h deficient or sufficient for TLR4 underwent heterotopic renal allograft transplantation, with an add

242 Heterotopic renal transplantation and bilateral native n

243 Heterotopic renal transplantation was performed in 20 do

244 more readily from orthotopic sites than from heterotopic sites, to identify metastasis-permissive tum

245 lls in orthotopic pancreatic tumours but not heterotopic skin tumours in mice to restrict pancreas-sp

246 Heterotopic slice transplant and explant cultures sugges

247 oth porcinized and humanized mouse models of heterotopic subcutaneous bronchus transplantation imitat

248 F/SF ligand significantly enhances growth of heterotopic subcutaneous xenografts derived from human M

249 and 126 specimens from the skin component of heterotopic swine hindlimb transplants.

250 and 126 specimens from the skin component of heterotopic swine hindlimb transplants.

251 rate that GABA-mediated synaptic function at heterotopic synapses is altered and suggests that inhibi

252 The heterotopic syngeneic murine head and neck cancer model

253 notably, there is an order of magnitude more heterotopic than homotopic projections; all cortical reg

254 ding pyramidal cell somata in normotopic and heterotopic tish neocortex.

255 g stromal or lymphoid proliferations or even heterotopic tissue.

256 cells to repopulate tumors in orthotopic and heterotopic tissues.

257 tors were upregulated during OB in the mouse heterotopic trachea model.

258 study evaluates the role of HO-1 in a murine heterotopic tracheal allograft model for obliterative br

259 Using this murine heterotopic tracheal allograft model, we evaluated the e

260 are the principal alloantigens in the mouse heterotopic tracheal model of obliterative bronchiolitis

261 ective role on chronic lung rejection in the heterotopic tracheal transplant model.

262 Heterotopic tracheal transplantation (HTT) mouse model w

263 hrough Smad3, in the development of OB using heterotopic tracheal transplantation in wild-type and Sm

264 Using the heterotopic tracheal transplantation model, we examined

265 amined using murine models of orthotopic and heterotopic tracheal transplantation.

266 literative airway disease (OAD) after murine heterotopic tracheal transplantation.

267 Murine heterotopic tracheal transplants into fully allogeneic m

268 Stuart Welch who performed a heterotopic transplant in the canine species in 1955.

269 Heterotopic transplantation in the rabbit does allow rec

270 five (R5, n=12) or nine (R9, n=12) prior to heterotopic transplantation into ACI recipients.

271 iversity of Wisconsin (UW) solution prior to heterotopic transplantation into syngeneic recipients.

272 Using a rat (Lewis-Wistar Furth) abdominal heterotopic transplantation model, we reported previousl

273 Beta-catenin co-expression, heterotopic transplantation of CNC cells into the pharyn

274 Heterotopic transplantation of donor hearts was performe

275 By utilizing a novel EFE model of heterotopic transplantation of hearts from newborn repor

276 Heterotopic transplantation of olfactory progenitors rev

277 (I-Ad restricted) TCR-Tg CD4+ T cells after heterotopic transplantation of OVA transgene-expressing

278 Following heterotopic transplantation of rhombomeres along the ros

279 in a model of atrophic remodeling induced by heterotopic transplantation of the rat heart (duration 1

280 In a model of atrophic remodeling induced by heterotopic transplantation of the rat heart, we measure

281 loading of failing rabbit hearts by use of a heterotopic transplantation technique could lead to reco

282 ed cells repopulated tracheal scaffolds in a heterotopic transplantation xenograft model.

283 In animal models of heterotopic transplantation, mechanical unloading of the

284 niquet placement or myocardial isolation via heterotopic transplantation.

285 tiation of these cells is also observed upon heterotopic transplantation.

286 Using heterotopic transplantations, we show that the fate of C

287 treatments need to consider the location of heterotopic transplants and administration of chemothera

288 Heterotopic transplants were performed using minor major

289 pathological retinal neovascularization and heterotopic tumor growth.

290 ing PHD3 were investigated in orthotopic and heterotopic tumor models.

291 dult tissues and in capillaries growing into heterotopic tumors expressed ADAMTS9.

292 d reduction in the spontaneous metastases of heterotopic tumors to the lungs of CXCR2(-/-) mice.

293 Valve-in-ring or heterotopic TV implantation procedures were not included

294 We performed heterotopic uterine transplants in genetically defined m

295 rized neonatal ear-heart transplantation and heterotopic vascularized heart transplantation models to

296 A rodent heterotopic working heart-lung transplantation model was

297 We have employed a rat heterotopic working-heart CR model for a magnetic resona

298 idual macrophages in vivo by MRI in a rodent heterotopic working-heart transplantation model using a

299 Herein, we establish 45 heterotopic WT patient-derived xenografts (WTPDX) in CB1

300 etry for IgG binding from sensitized cardiac heterotopic xenograft recipients.