ライフサイエンスコーパス: heterozygous mice

1 ventricular bundle hypoplasia after birth in heterozygous mice.

2 atterns were similar for both homozygous and heterozygous mice.

3 limit fibrosis induced by bleomycin in mTERT heterozygous mice.

4 a4(+/+) mice and approximately 20% higher in heterozygous mice.

5 gic synaptic plasticity in the BLA from Nrg1 heterozygous mice.

6 logic features, compared with the respective heterozygous mice.

7 blasts (MEF) cells derived from wildtype and heterozygous mice.

8 ce show significantly higher incidences than heterozygous mice.

9 rdiomyocyte (CM)-specific HIPK2 knockout and heterozygous mice.

10 ared with sister cultures from wild-type and heterozygous mice.

11 ffects of cytomegalovirus infection in Trp53 heterozygous mice.

12 ve phenotype previously described for global heterozygous mice.

13 both BACE1 null and, surprisingly, in BACE1 heterozygous mice.

14 We have now extended this result for female heterozygous mice.

15 of Prox1, as the valves are absent in Prox1 heterozygous mice.

16 dle cell sarcoma, and thymic lymphoma in p53 heterozygous mice.

17 kidney fibrosis is ameliorated in Dnmt1(+/-) heterozygous mice.

18 ppression of intestinal tumorigenesis in Apc heterozygous mice.

19 s spontaneous pituitary tumorigenesis in p27 heterozygous mice.

20 s with latency and spectrum similar to Trp53 heterozygous mice.

21 nst overall insulin resistance compared with heterozygous mice.

22 nted increase in IOP in comparison to WT and heterozygous mice.

23 rily affects the cells of the GCL in younger heterozygous mice.

24 nner, rescuing the obesity phenotype in Sim1 heterozygous mice.

25 we have generated Six3+/- ;Hesx1Cre/+ double heterozygous mice.

26 errupted aortic arch when compared with Tbx1 heterozygous mice.

27 me 9 in radiation-induced lymphomas from p53 heterozygous mice.

28 ild type and C3H alpha7 receptor null mutant heterozygous mice.

29 enic response to FGF is recapitulated in Vhl-heterozygous mice.

30 inactivation that would be present in female heterozygous mice.

31 the high levels of phosphorylated S6 in Tsc2-heterozygous mice.

32 generated Scn1a(+/-); Scn8a(med-jo/+) double heterozygous mice.

33 body weight when compared with wild-type or heterozygous mice.

34 ve compliance relative to wild-type (WT) and heterozygous mice.

35 cally or overexpressed in the context of Atm heterozygous mice.

36 ect of Nras loss on tumor development in Rb1 heterozygous mice.

37 orphology, and exercise capacity in compound-heterozygous mice.

38 d2 deficient mice with p53 deficient and p53 heterozygous mice.

39 imals, but lung PtdCho mass decreased in the heterozygous mice.

40 adult liver and other tissues from Pcyt1a+/- heterozygous mice.

41 re delivered to the livers of p19Arf-null or heterozygous mice.

42 post-azoxymethane injection in wild-type and heterozygous mice.

43 feron type I receptor were similar in KO and heterozygous mice.

44 ar function in beta-isoproterenol-stimulated heterozygous mice.

45 served analogous lymphocyte defects in Bach2-heterozygous mice.

46 es taken from BAF53b transgenic mice but not heterozygous mice.

47 impairs heat hyperalgesia in homozygous and heterozygous mice.

48 BAF53b transgenic mice compared with BAF53b heterozygous mice.

49 e on electroretinography (ERG) in UBE3D(+/-) heterozygous mice.

50 confirmed a reduced clearing ability in the heterozygous mice.

51 e viral cyclin was dispensable in p18(INK4c) heterozygous mice.

52 hearing loss in all homozygous-null, but not heterozygous, mice.

53 induced diabetes in wild type (+/+) and CTGF heterozygous (+/-) mice.

54 oplastic stage of medulloblastoma in patched heterozygous mice, a model of the human disease.

55 lyses indicate that in Eya1 hypomorphic/null heterozygous mice, a reduction of Eya1 expression to 21%

56 removed by chromosome deletion from the E2A heterozygous mice, a result consistent with the required

57 in plasma membrane calcium ATPase 2 (PMCA2) heterozygous mice: a possible modality- and sex-specific

58 han other Atoh1-positive cell types and that heterozygous mice actually develop hearing loss late in

59 The Cbs(+/+) (wild type) and Cbs(+/-) (heterozygous) mice (aged 16 to 52 weeks) were subjected

60 Heterozygous mice also develop pancreatic cancer suggest

61 Moreover, 37.5% of pol eta heterozygous mice also developed skin cancer during 5 mo

62 Type III Nrg1 heterozygous mice also have impaired performance on dela

63 +/Pcdh15(av-3J) +/Ush1g(js) double heterozygous mice also showed elevated hearing loss, sug

64 e as no homozygous embryos were observed and heterozygous mice also showed embryonic lethality (haplo

65 Smg1 heterozygous mice also showed evidence of oxidative dama

66 ted PDAC development of KRAS(G12D) INK4A/ARF heterozygous mice and altered the tumor phenotype; while

67 ally reduced in spermatocytes from testes of heterozygous mice and further reduced in homozygous null

68 en in the Huntington's disease (HD) FEN1 +/- heterozygous mice and myotonic dystrophy type 1 (DM1) FE

69 Parity protection was limited to p53 heterozygous mice and not found in mice with increased E

70 ted differences in PPI between type III Nrg1 heterozygous mice and their wild-type littermates.

71 l cortex and hippocampus of 6-month-old BDNF heterozygous mice and wild type littermates by using pol

72 r blood vessels were increased in Claudin 14-heterozygous mice, and in VEGF-stimulated angiogenesis e

73 layers in cbs homozygous mice and older cbs heterozygous mice, and it primarily affects the cells of

74 and myotonic dystrophy type 1 (DM1) FEN1 +/- heterozygous mice, and suggest that inefficient flap pro

75 smaller lesions compared with wild-type and heterozygous mice, and there were no significant differe

76 Adult heterozygous mice appeared normal and exhibited no evide

77 Prox1 heterozygous mice are a new model for adult-onset obesit

78 As Atad5 heterozygous mice are cancer-prone and as ATAD5 mutation

79 Heterozygous mice are characterized by repeated hair los

80 We found that Nedd4-2 heterozygous mice are hyperactive, have increased basal

81 While single heterozygous mice are normal, double heterozygous embryo

82 Additionally, Mdm2+/- Mdm4+/- double-heterozygous mice are not viable and exhibit defects in

83 In contrast, heterozygous mice are overtly and histologically indisti

84 ynapsin, whereas the levels in wild-type and heterozygous mice are undetectable.

85 gh homozygous deletion of Poldip2 is lethal, heterozygous mice are viable and show protection against

86 versed the increase in permeability in KRIT1 heterozygous mice as shown by intravital microscopy.

87 MYH4(L342Q) is present in muscles from heterozygous mice at only 7% of the levels of the wild-t

88 e directly on the T cell as Motheaten viable heterozygous mice autoreactive T cells are not anergized

89 g the dynamic changes in iron balance in Pcm heterozygous mice between 3 and 12 weeks of age.

90 We studied Bmpr2 heterozygous mice (Bmpr2(+/-)), mice with hepatocyte-spe

91 NA levels were observed in 18-month-old BDNF heterozygous mice but not in 7-day-old mice, suggesting

92 GluN2C/2D potentiator in wildtype and GluN2C heterozygous mice but not in GluN2C knockout mice.

93 inal peptide (VIP) induced REMS responses in heterozygous mice but not in KO mice.

94 f rhabdoid tumors in vivo, we developed Ini1 heterozygous mice by targeted disruption.

95 ough precancerous lesions were found in Pten heterozygous mice, cancer progression and metastasis onl

96 Here, we report that cardiac myocytes of heterozygous mice carrying a catecholaminergic polymorph

97 We have now analyzed compound heterozygous mice carrying a duplication [Dp(11)17] in o

98 Heterozygous mice carrying a null mutation at the gamma-

99 on, homozygous fII(lox/lox) mice or compound heterozygous mice carrying one fII(lox) allele and one c

100 To do this we generated Trp53 heterozygous mice carrying the T2/Onc transposon and SB1

101 e terminal differentiation, we used compound heterozygous mice carrying the W (null) and W(v) (domina

102 Genetic ablation of CBS in CBS heterozygous mice (CBS(+/-) ) reduced the number of muta

103 In CBS heterozygous mice (cbs(+/-)) and primary neurons deplete

104 r cell-enriched transcripts in the Gfi1(Cre) heterozygous mice cochleae compared with their wild-type

105 e intolerance developed in aged (>10 months) heterozygous mice compared to littermate controls.

106 idal neuron responsivity was observed in the heterozygous mice compared to the wild type mice.

107 quences of PLAG1 deficiency in knock-out and heterozygous mice compared to wild-type mice using RNA-s

108 ) and +/Myo7a(sh1-8J) +/Pcdh15(av-3J) double heterozygous mice compared with age-matched single heter

109 o be unchanged in the Brca1-MG-Deltaex11;Atm heterozygous mice compared with Brca1-MG-Deltaex11;Atm w

110 HSC (ST-HSC) populations are expanded in Apc-heterozygous mice compared with the control littermates;

111 on and lifespan after gamma-radiation in Atm heterozygous mice compared with their wild-type control

112 eritonitis after Cx43 inhibition and in Cx43 heterozygous mice compared with untreated and wild-type

113 on for reward were also exhibited by Ank3+/- heterozygous mice compared with wild-type Ank3+/+ mice.

114 on in vivo in Themis(I23N/+):Lck(-/+) doubly heterozygous mice demonstrate that functional coupling o

115 The Mtap heterozygous mice demonstrated changes in metabolic and

116 following vascular injury in vivo, GABPalpha-heterozygous mice demonstrated reduced KIS gene expressi

117 In contrast to control and heterozygous mice, Depdc5-Emx1-Cre conditional knockout

118 Dmrt2 heterozygous mice derived from these cells are phenotypi

119 emic diet, cystathionine beta-synthase (Cbs)-heterozygous mice develop hyperhomocysteinemia.

120 Heterozygous mice develop lymphomas at an intermediate r

121 The heterozygous mice develop normally, with no changes in r

122 We now report that dab2 heterozygous mice develop uterine hyperplasia and ovaria

123 These heterozygous mice developed muscle weakness and myofibri

124 ctionated by gender, however, homozygous and heterozygous mice developed spontaneous tumors more rapi

125 ciated with 22q11.2 haploinsufficiency, Tbx1 heterozygous mice did not display these behavioral abnor

126 Because prior studies of Atoh1-heterozygous mice did not examine or report on hearing l

127 Bru heterozygous mice display defects similar to Axenfeld-Ri

128 EF2C, and DNA binding-deficient Mef2c global heterozygous mice display numerous MCHS-related phenotyp

129 m heterozygosity, but Brca1-MG-Deltaex11;Atm heterozygous mice displayed decreased ductal branching d

130 However, and surprisingly, Claudin 14-heterozygous mice displayed several blood vessel-related

131 k-out mice, when compared with wild-type and heterozygous mice, displayed a 7-9.7% decrease in lifesp

132 Although, Pax3 heterozygous mice do not show ENS defects, compound Pax3

133 f compensating for the deleted copy and that heterozygous mice do not suffer peripheral hearing impai

134 nd null mice develop cardiomyopathy, whereas heterozygous mice do not.

135 of RNA isolated from wild-type and Tcof1+/- heterozygous mice embryos from strains that exhibit a le

136 This function was tested in endoglin heterozygous mice (Eng(+/-)) and their wild-type sibling

137 The activation of efferent neurons in heterozygous mice evoked biphasic postsynaptic currents

138 All the tumors from heterozygous mice examined retain the wild-type allele a

139 do not show ENS defects, compound Pax3;Tcof1 heterozygous mice exhibit cumulative apoptosis which sev

140 Here we show that Grb2 heterozygous mice exhibit decreased susceptibility to Fr

141 Conversely, miR-34a knockout and heterozygous mice exhibit elevated bone resorption and r

142 Myc heterozygous mice exhibit extended lifespans resulting f

143 Survived adult heterozygous mice exhibit frequent haemorrhages and incr

144 Skeletal muscles from heterozygous mice exhibit increased susceptibility to ca

145 ath between P16 and P26, whereas Scn1a(RH/+) heterozygous mice exhibit infrequent spontaneous general

146 Doubly heterozygous mice exhibit progressive hyperglycemia, hyp

147 Adult Zeb1 heterozygous mice exhibit these same corneal defects.

148 n apparent normal VMH cytoarchitecture, sf-1 heterozygous (+/-) mice exhibited diet-induced obesity w

149 NHE1(+/+) mice treated with HOE 642 or NHE1 heterozygous mice exhibited a approximately 33% decrease

150 ddition, CM-HIPK2 knockout mice and CM-HIPK2 heterozygous mice exhibited a gene dose-response relatio

151 least one of the two genes because compound heterozygous mice exhibited a prostatic phenotype that w

152 Arid1b-heterozygous mice exhibited abnormal cognitive and socia

153 ivated Protein C (aPC), plasma from Pros1+/- heterozygous mice exhibited accelerated thrombin generat

154 The surviving heterozygous mice exhibited altered glucose metabolism,

155 BDNF heterozygous mice exhibited an increase in CXCR4 mRNA co

156 mPGES-1 null and heterozygous mice exhibited decreased incidence and seve

157 Under these pathological conditions, heterozygous mice exhibited localized vascular abnormali

158 These heterozygous mice exhibited no vascular defects until ch

159 The C3H alpha7 heterozygous mice exhibited significant reductions in hi

160 itivity and tumour predisposition, with Helq heterozygous mice exhibiting a similar, albeit less seve

161 mors and pretumor cells derived from patched heterozygous mice express high levels of Mad3 compared w

162 Heterozygous mice expressing the human MH/central core d

163 h was induced in cystathionine-beta synthase heterozygous mice fed a high-methionine diet for 8 weeks

164 deficient mice (Fg(-/-)) in comparison with heterozygous mice (Fg(+/-)) to point the proinflammatory

165 Heterozygous mice for the G90D mutation did not exhibit

166 K18-null but not K8-null or heterozygous mice form MBs, which indicates that K8 is i

167 lyzed modifiers of an eye defect in Jag1del1 heterozygous mice from this same cross.

168 Observations in heterozygous mice further support a role for relative N

169 Heterozygous mice had a twofold increase in these projec

170 ce were devoid of type XIV collagen, whereas heterozygous mice had reduced synthesis.

171 e-body exposure to ionizing radiation, Brca1 heterozygous mice have a 3-5-fold higher incidence speci

172 Trim21 heterozygous mice have a haploinsufficiency phenotype in

173 Fos mice have no multinucleated osteoclasts, heterozygous mice have a reduction in the number of oste

174 IFIH1 heterozygous mice have a regulatory rather than effector

175 tic metabolomic analyses revealed that SIRT1 heterozygous mice have elevated gluconeogenesis and oxid

176 ependence in cells, intestine-specific Sirt1 heterozygous mice have enhanced intestinal tumor formati

177 EPAS1-null as well as heterozygous mice have impaired renal erythropoietin ind

178 Heterozygous mice have less extensive ICC hyperplasia an

179 ars embryonic-lethal in homozygous mice, but heterozygous mice have no alterations at baseline.

180 Whereas Ctla4 heterozygous mice have no obvious phenotype, human CTLA4

181 The Mmp20 heterozygous mice have normal-appearing enamel, with Vic

182 Herein, using Hhip heterozygous mice (Hhip(+/-)), we observed increased lun

183 neered mice, with human P2X7R, revealed that heterozygous mice (i.e., they coexpress the disease-asso

184 roximal to the Sod2 start site in PGC-1alpha heterozygous mice, implicating PGC-1alpha in facilitatio

185 It is deficient in EC-SMC Bmpr2 double heterozygous mice in association with reduced collagen I

186 in-A1 is a feature of tumors arising in Hic1 heterozygous mice in which the remaining wild-type allel

187 cies arising in NrasG12D/G12D,C181S compound heterozygous mice invariably acquired revertant mutation

188 atio in skeletal muscles from RyR1Q1970fsX16 heterozygous mice is lower compared to that from WT mice

189 e these defects, rod-mediated sensitivity in heterozygous mice is not decreased to the extent seen in

190 e show that on a C57BL/6 background, jagged1 heterozygous mice (Jag1(+/-) ) exhibit impaired intrahep

191 Compound-heterozygous mice lacking 1 copy of Pkd1 and Taz exhibit

192 xclusively progerin (Lmna HG) and found that heterozygous mice (Lmna HG/+) exhibit many phenotypes of

193 Heterozygous mice (Lrat(+/L3)) were crossed with mice ex

194 s study is to determine whether Zeb1 null or heterozygous mice may provide an animal model for PPCD.

195 y loss of Ptch1 in Ptch1(+/-)/ODC(t)/C57BL/6 heterozygous mice may provide insights about the cancer

196 DNA binding-deficient global Mef2c heterozygous mice (Mef2c-Het) displayed numerous MCHS-re

197 Since the expression profile in the heterozygous mice mimicked viral transduction, we conclu

198 induced calcium transients in RyR1Q1970fsX16 heterozygous mice muscles were decreased by 20% and 15%,

199 In vitro, islets of NHA2-deficient and heterozygous mice, NHA2-depleted Min6 cells, or islets t

200 udied Prkar2a and Prkar2b knock out (KO) and heterozygous mice; none of these mice developed bone les

201 We have previously shown that male Npc1 heterozygous mice (Npc1(+/-)), as compared to homozygous

202 We also found that Atoh1 heterozygous mice of both sexes (Atoh1(lacZ/+)) have adu

203 s in genetic background, we crossed Jag1del1 heterozygous mice onto the same genetic background as th

204 heterozygous (+/-) mice, Pten and Fyn double heterozygous (+/-) mice, or Fyn knockout (-/-) mice conf

205 Moreover, double-heterozygous mice (ostes/+, Tg(Pkd1l2)/0) suffer from my

206 d1(m1Bei) and Runx2-II mice to create double heterozygous mice (Pkd1(+/m1Bei)/Runx2-II(+/-)) deficien

207 Tbx1(-/+)/Pitx2(-/+) double heterozygous mice present with an extra premolar-like to

208 ing to demonstrate that the PVN of germ line heterozygous mice projects normally to the dorsal vagal

209 Thus, Nedd4-2 heterozygous mice provide a new genetic model to study i

210 By combining SB mutagenesis with Patched1 heterozygous mice (Ptch1(lacZ/+)), we observed an increa

211 cytes from Fyn heterozygous (+/-) mice, Pten heterozygous (+/-) mice, Pten and Fyn double heterozygou

212 interfering RNA and (b) astrocytes from Fyn heterozygous (+/-) mice, Pten heterozygous (+/-) mice, P

213 tics of skeletal muscles from RyR1Q1970fsX16 heterozygous mice recapitulates that of the heterozygous

214 notype of the RyR1Q1970fsX16+A4329D compound heterozygous mice recapitulates the clinical picture of

215 mice show more severe defects compared with heterozygous mice reflecting the dominant and dose-depen

216 eover, loss of one allele of Notch1 in Prox1 heterozygous mice rescued embryonic lethality due to Pro

217 gical activation of CREB in the female Mecp2 heterozygous mice rescued several behavioral defects.

218 ration of Trps1(DeltaGT/+);Runx2(+/-) double heterozygous mice rescued the opposite growth plate phen

219 7beta-estradiol pellets in adult female Pten heterozygous mice, resulting in increased carcinoma inci

220 y deficits observed in the alpha2 and alpha3 heterozygous mice reveal the Na,K-ATPase to be an import

221 Magnetic resonance imaging of type III Nrg1 heterozygous mice revealed hypofunction in the medial pr

222 cardiac skinned fibers isolated from WT and heterozygous mice revealed that the WT cTnI was complete

223 ved from WT/Delta locus control region (LCR) heterozygous mice reveals no significant H3 K79 dimethyl

224 zygous animals and alpha7 nicotinic receptor heterozygous mice reveals that the sustained phase of po

225 To this end, SERCA2 heterozygous mice (S2HET) were challenged with a high-fa

226 UPR acting in pro-survival mode, Enamp.S55I heterozygous mice secreted structurally normal enamel.

227 Both homozygous and heterozygous mice show a decline in survival compared to

228 In vivo, Akt3-null and heterozygous mice show dose-dependent decreases in angio

229 NeuroD2 heterozygous mice show profound deficits in emotional le

230 In contrast, P30 Jag1/Rumi double-heterozygous mice show well-developed portal triads arou

231 Arid1b-heterozygous mice showed a decreased number of cortical

232 In addition, mPGES-1 null and heterozygous mice showed a marked reduction of serum IgG

233 O mice were early embryonic lethal, but Smg1 heterozygous mice showed a predisposition to a range of

234 Primary hippocampal cells derived from heterozygous mice showed an attenuated calcium uptake up

235 In this study, we found that: (i) Mecp2 heterozygous mice showed deficiency of GABA perisomatic

236 Fbw7(Delta/+) heterozygous mice showed haploinsufficiency for Notch de

237 Finally, endothelial Notch1 heterozygous mice showed higher diet-induced atheroscler

238 Lastly, BDNF heterozygous mice showed higher levels of CCR5 and CXCR3

239 nsistent with this ex vivo observation, KLF2 heterozygous mice showed increased microvessel density i

240 We found that Nf1 heterozygous mice showed increased neovascularization in

241 Both homozygous and heterozygous mice showed reduced glutamatergic transmiss

242 cked GnRH neurons in the hypothalamus, while heterozygous mice showed substantial decreases in the nu

243 specific expression of Cdkn2b transcripts in heterozygous mice showed that the deletion affects expre

244 a exhibits a strong gene dosage effect, with heterozygous mice showing approximately 2-fold reduction

245 of bdnf I and IV in the VMH were reduced in heterozygous mice similar to levels observed in fasted w

246 a3+/+ and alpha3-/- littermates delivered by heterozygous mice soon after their exposures to ETS or e

247 ough partial reduction of GRP78 in the Grp78 heterozygous mice substantially reduces the tumor microv

248 Cdk2 wild-type or heterozygous mice succumbed to mammary tumors with mean

249 A144E heterozygous mice, such as TACI(+/-) mice, expressed hal

250 In contrast to Ptch1 heterozygous mice, Sufu heterozygotes had no development

251 itioning and novel object recognition in I-2 heterozygous mice suggest that I-2 is a memory suppresso

252 The neurobehavioral changes seen in heterozygous mice suggest that these mouse models may be

253 equent higher mortality were not observed in heterozygous mice, suggesting that one allele of betaArr

254 Heterozygous mice tended to have thicker corneas (3.4%).

255 ting ADIPOQ protein level were lower in Brd4 heterozygous mice than in wild-type mice at 21 days afte

256 examined the immune response to gammaHV68 in heterozygous mice that have an autosomal dominant mutati

257 enewal capacity with progressive breeding of heterozygous mice that was indistinguishable from that o

258 mice that received vehicle alone or control (heterozygous) mice that received vehicle.

259 Heterozygous mice (the same frizzled 9 genotype as Willi

260 However, in contrast to global heterozygous mice, the behavioral changes induced by gam

261 Compared with wild-type or Rac1 heterozygous mice, the hearts of c-Rac1(-/-) mice showed

262 In Arc-positive GFP heterozygous mice, the pattern of GFP-positive cells exh

263 1.2(I1624E) mutation were generated in adult heterozygous mice through inactivation of the floxed WT

264 by 53BP1 deletion, and it predisposes BRCA1 heterozygous mice to cancer.

265 We used 3T3-L1 adipocytes and Brd4 heterozygous mice to investigate whether the induction o

266 prospero-related homeobox protein 1 (Prox1) heterozygous mice, using pressure-volume loop and microm

267 In VMD2-Cre heterozygous mice variable progressive age-dependent RPE

268 Notably, seizure induction in heterozygous mice was accompanied by enhanced reporter e

269 -induced B-cell lymphoma development in Mtbp heterozygous mice was profoundly delayed.

270 social communication and interaction in TSC2 heterozygous mice, we recorded ultrasonic vocalizations

271 In vivo, wild-type and Ngn-3-heterozygous (+/-) mice were subjected to 3,5-diethoxyca

272 In addition, Cyp17a1 heterozygous mice were also backcrossed onto an Apoe KO

273 Mammary tumors from Brca1-MG-Deltaex11;Atm heterozygous mice were anaplastic and undifferentiated i

274 Pmm2(R137H/F115L) mice, but their levels in heterozygous mice were comparable to wild-type (WT) litt

275 lethal renal phenotype, Aqp11-/sjds compound heterozygous mice were generated from Aqp11 +/sjds and A

276 tic bile duct cells from Tsc1, Tsc2 and Pkd1 heterozygous mice were highly misoriented.

277 l IOPs of C57Bl/6x129SvJ WT, SPARC-null, and heterozygous mice were measured.

278 richment of mannosyl compounds and glycogen, heterozygous mice were normal, arguing against possible

279 ced more tumors than wild-type mice, whereas heterozygous mice were not statistically different.

280 Heterozygous mice were phenotypically normal and in situ

281 Skeletal myoblasts derived from SIRT1+/- heterozygous mice were resistant to the effects of eithe

282 Wildtype, COX-2 knockout and COX-2 heterozygous mice were subjected to a model of colonic a

283 When Tert(+/-) heterozygous mice were successively cross-bred through 1

284 ncy induced hematopoietic dysplasia, and Eed heterozygous mice were susceptible to malignant transfor

285 , Atm heterozygous as well as Atm/P53 double heterozygous mice were treated with ionizing radiation.

286 onstrated early embryonic lethality, whereas heterozygous mice were viable, but developed signs of hy

287 genetic model of breast cancer in the Grp78 heterozygous mice where GRP78 expression level was reduc

288 Motheaten viable heterozygous mice, which contain a mutation in the SHP-1

289 Heterozygous mice, which correspond to the human occurre

290 w medulloblastoma model by crossing Patched1 heterozygous mice, which develop medulloblastomas with l

291 ator of the HCM response, and compound VM/RC heterozygous mice, which developed a severe HCM phenotyp

292 The bone phenotype of the heterozygous mice, which have 79-84% of wild-type Runx2

293 We generated Arid1b heterozygous mice, which showed social behavior impairme

294 Tumour growth/angiogenesis is reduced in heterozygous mice, which was associated with reduced act

295 Heterozygous mice with forebrain Cul3 deletion displayed

296 esizing MEE cells following mating Tgf-beta3 heterozygous mice with Keratin 14 promoter directed Smad

297 were induced by the transduction of p53(+/-) heterozygous mice with lentiviral vectors containing onc

298 Our results show that heterozygous mice with mutations in the myosin motor or

299 e cellular phenotype and barrier function in heterozygous mice with simvastatin, a drug known to inhi

300 We generated compound heterozygous mice with the R137H and F115L mutations in