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1 cient to obtain gene conversion in initially heterozygous mutants.
2 alues of both positive and negative dP/dt in heterozygous mutants.
3 bosis response was severely reduced for both heterozygous mutants.
4 e dental epithelium and mesenchyme of double heterozygous mutants.
5 ignificantly reduced in Clock homozygous and heterozygous mutants.
6  that was no more severe than that of single heterozygous mutants.
7  of wild-type alpha1beta2gamma2 receptors or heterozygous mutant alpha1(A322D)beta2gamma2 receptors,
8 rafficking and/or accelerated endocytosis of heterozygous mutant alpha1beta2gamma2 receptors containi
9                                              Heterozygous mutants also exhibited delayed recovery of
10 cartilage from the knee joints of the double-heterozygous mutant and surgically treated mice were exa
11  copy numbers in ovulated oocytes from EndoG heterozygous mutant and wild-type mice are similar, sugg
12 e strain but decreasing catalase activity in heterozygous mutants and no detectable catalase in a hom
13                                      We used heterozygous mutants and targeted RNA interference-media
14 t quail exhibited gray plumage, whereas MLPH heterozygous mutants and wild-type quail exhibited dark
15 between those persons who were homozygous or heterozygous mutants and wildtype/pseudo-wildtype (p = 0
16 e 73.3% for p53 wild-type fetuses, 52.5% for heterozygous mutants, and 2.2% for p53-null mutants.
17 our onset, incidence and progression in Pten-heterozygous mutants, and leads to female sterility with
18                                           In heterozygous mutant animals, we observed a relative decr
19 um stress, and fecundity enhancement in E(z) heterozygous mutants are accompanied by changes in the e
20           We also show that Xpc Trp53 double heterozygous mutants are more predisposed to skin cancer
21                      Prior to seizure onset, heterozygous mutants are not defective in motor learning
22 enes expressed during wing development in 27 heterozygous mutants, as well as their co-isogenic wild
23                       Here we show that aged heterozygous mutant (Atp2a2(+/-)) mice develop squamous
24 ables instant germline modifications, making heterozygous mutants available within 18 wk.
25 res from E12.5 homozygous mutant (bcl-x-/-), heterozygous mutant (bcl-x+/-), and wild-type (bcl-x+/+)
26 one morphogenetic protein receptor-2 (BMPR2)-heterozygous, mutant (BMPR2(+/-)) mice have a genetic tr
27                           In contrast to all heterozygous mutants, both systolic and diastolic functi
28                                              Heterozygous mutant BRCA1 cell clones also showed a high
29                       We found that even the heterozygous mutant cell lines showed cell survival defe
30                            We show that Apex heterozygous mutant cells and animals are abnormally sen
31 selectively targeting the WT U2AF1 allele in heterozygous mutant cells could induce cancer cell death
32                                        While heterozygous mutant cells had diminished signaling in re
33                     When compared with Ptch1 heterozygous mutants, compound Ptch1/Hic1 heterozygotes
34 nctionally independent domains, we undertook heterozygous mutant crossing between Phr1(Delta8,9) and
35 ar, both male and female homozygous and male heterozygous mutants develop impaired glucose tolerance
36                       Interestingly, the MK2 heterozygous mutants display an intermediate level of pr
37                                Ventricles of heterozygous mutants displayed a 50% reduction in mlc-2v
38                              In mouse, Hnf1b heterozygous mutants do not exhibit any phenotype, where
39  Myocardial hypoplasia in GATA4/GATA6 double heterozygous mutant embryos is associated with reduced p
40  finding of exencephaly in about 15% of rybp heterozygous mutant embryos, and by Rybp's distinct neur
41  misexpressed in engrailed cells in hedgehog heterozygous mutant embryos, larvae show a dominant phen
42                                    Using p53 heterozygous mutant epithelial cells from Li-Fraumeni sy
43                                 Although the heterozygous mutant ES cells were able to generate low c
44                                              Heterozygous mutants exhibited cardiac function comparab
45                                Finally, BIR1 heterozygous mutants exhibited grossly altered cell morp
46 hat deletion of the WT allele in U2AF1(S34F) heterozygous mutant-expressing hematopoietic cells (i.e.
47 g ENL tumor (ENL(T)) mutations and show that heterozygous mutant expression in Six2(+) nephrogenic or
48  increase in foxc1a levels in homozygous and heterozygous mutant eyes, suggesting a mechanism for fox
49                       Compound Cdc42, tinman heterozygous mutant flies exhibited impaired cardiac out
50 phenotypic characterization of mice that are heterozygous mutants for the Apex gene (Apex+/-).
51                                              Heterozygous mutants (Foxc1(+/-) and NC-Foxc1(+/-)) exhi
52 s knockout (SR-/-) and glycine transporter 1 heterozygous mutant (GlyT1-/+).
53 coding PMCA1 caused embryolethality, whereas heterozygous mutants had no overt disease phenotype.
54                                          The heterozygous mutant has no overt phenotype, and its leaf
55                                              Heterozygous mutants have 67% of the enzyme activity of
56                                              Heterozygous mutants have axonal defects in the adult ey
57 hus, heterozygous and homozygous or compound heterozygous mutants have very different clinical phenot
58 t of WT KRAS with a mutant allele sensitized heterozygous mutant HCT116 cells to treatment.
59 CA2 mRNA was reduced by approximately 45% in heterozygous mutant hearts and that SERCA2 protein and m
60 crog/L; 24 had homozygous mutant or compound heterozygous mutant HFE genotypes.
61 can affect muscle function, we have analyzed heterozygous mutants in depth.
62 f chondrogenesis and osteogenesis, while the heterozygous mutant is dwarfed.
63 mal gene can be disrupted, and the resulting heterozygous mutant is unlikely to display a phenotype.
64 s, the phenotype of the lymph gland of Zfpr8 heterozygous mutants is dominantly enhanced by the l(1)d
65  ciliary ganglion and we find that in Phox2b heterozygous mutants it is highly atrophic.
66                       By contrast, kinesin-8 heterozygous mutant (KIP3/kip3) spindles exhibited the s
67                                              Heterozygous mutant Kit(V558Delta)/+ mice that develop s
68                                              Heterozygous mutant KitV558Delta/+ mice develop symptoms
69  comparison with wild-type alphaA protein of heterozygous mutant lenses.
70                                          The heterozygous mutant (LPAT2/lpat2) had minimal altered ve
71                                              Heterozygous mutant (luxoid.Zbtb16(LU)/J) mice deficient
72                                          The heterozygous mutant mice (Acc1(+/-)) had normal fertilit
73 e phenotypes in growth plate chondrocytes of heterozygous mutant mice (Gnas(+/E2-)).
74                                              Heterozygous mutant mice (ngf+/-) have reduced levels of
75                                          The heterozygous mutant mice also developed similar prostati
76 in the mammalian heart, we examined compound heterozygous mutant mice and found conduction system and
77                 The abnormal EEG patterns in heterozygous mutant mice and the influence of genetic ba
78                                        Snf2h heterozygous mutant mice are born at the expected freque
79             In addition, both homozygous and heterozygous mutant mice are highly resistant to the sei
80 oints was dramatically reduced in the double-heterozygous mutant mice compared with that in the type
81 nally, we propose that soluble KITL in Sld/+ heterozygous mutant mice complements a dosage effect of
82                                              Heterozygous mutant mice demonstrate behavioural, neuroa
83                          We report here that heterozygous mutant mice develop into adulthood without
84                          We report here that heterozygous mutant mice develop into adulthood without
85                                          The heterozygous mutant mice display insulin hypersensitivit
86                                          The heterozygous mutant mice do not develop seizures.
87                                     The Chd2 heterozygous mutant mice exhibit increased extramedullar
88 nterestingly, we found that cells from EndoG heterozygous mutant mice exhibit increased resistance to
89                               Homozygous and heterozygous mutant mice exhibited altered hippocampal m
90 ectrophysiological studies demonstrated that heterozygous mutant mice have a specific defect in hippo
91 opment, we generated, through breeding, IRF4 heterozygous mutant mice in the NZB background (NZB IRF4
92 taneous cell death of spermatogonia in EndoG heterozygous mutant mice is significantly reduced compar
93 ed an F2 intercross between insulin receptor heterozygous mutant mice on B6 and 129/Sv backgrounds (B
94                         However, breeding of heterozygous mutant mice on the 129 background generated
95                         Closer inspection of heterozygous mutant mice revealed a range of defects wit
96                                              Heterozygous mutant mice show a phenotype similar to hum
97                 Fibroblasts taken from adult heterozygous mutant mice show an apparent alteration in
98 scular endothelial cells isolated from Foxc2 heterozygous mutant mice showed a marked reduction in It
99                                              Heterozygous mutant mice showed postnatal growth delay w
100                       The resulting compound heterozygous mutant mice showed significantly accelerate
101                The progression in the double-heterozygous mutant mice was delayed by approximately 6
102 , microvessel outgrowth from aortas of Foxc2 heterozygous mutant mice was reduced.
103                                              Heterozygous mutant mice were found to develop severe he
104                                              Heterozygous mutant mice were viable, but embryos exhibi
105                                        Adult heterozygous mutant mice with a targeted disruption for
106                                              Heterozygous mutant mice with deletion of hypoxia-respon
107                                    Mating of heterozygous mutant mice yielded wild-type and heterozyg
108 f osteoclasts were not altered in the double heterozygous mutant mice, indicating that the defect lie
109 chanism of MHE, both Ext1(+/-) and Ext2(+/-) heterozygous mutant mice, which mimic the genetic status
110 ciency also accelerated tumorigenesis in p53 heterozygous mutant mice.
111 ter behavioral recovery than in wild-type or heterozygous mutant mice.
112 f the Steel locus increase TGCT incidence in heterozygous mutant mice.
113  disease was only evident in homozygous, not heterozygous, mutant mice.
114 omal breaks as well as aneuploidy in primary heterozygous mutant mouse embryonic fibroblasts.
115                                Analysis of a heterozygous mutant mouse in which the NF-kappaB-depende
116 phenotypes, our lab recently created a Myt1l heterozygous mutant mouse inspired by a clinically relev
117 which manifests as visual dysfunction in the heterozygous mutant mouse, B6;C3-Opa1(Q285STOP).
118 rs for Parkinson's disease (PD) are a set of heterozygous mutant (MT) alleles of the GBA1 gene that e
119 , a finding relevant to our understanding of heterozygous mutant myosins found in disease states like
120 ablated in Schwann cells in the context of a heterozygous mutant (Nf1+/-) microenvironment.
121 ablated in Schwann cells in the context of a heterozygous mutant (Nf1+/-) microenvironment.
122 trocytes from NKCC1 wild-type (NKCC1+/+) and heterozygous mutant (NKCC1+/-) mice.
123          When the mutations were examined in heterozygous mutant/nonmutant genotypes, more than half
124 the activity of the wild-type transposase in heterozygous mutant/nonmutant genotypes.
125 for the first time a new type of Odf2-DDS in heterozygous mutant Odf2(+/-) mice.
126 ary phase survival was prolonged in a double heterozygous mutant of the metabolic enzyme non-quiescen
127 ductive tracts of Hoxa-10 and Hoxa-11 single heterozygous mutants of both sexes were primarily unaffe
128        Second, we study climbing behavior of heterozygous mutants of genes implicated in the fly PD m
129 urbations of the cell cycle oscillator using heterozygous mutants of mitotic kinases and phosphatases
130       We show a genetic interaction in trans-heterozygous mutants of phosphatidylserine synthase and
131 rease in deposition of AA when compared with heterozygous mutant or wild-type animals.
132 us mutants spontaneously form cysts, whereas heterozygous mutants (original or base corrected) expres
133 ic mice bearing both the v-Ha-ras gene and a heterozygous mutant p53 allele tend to retain the Ink4a
134 cted with an apparent dominant ZSD in whom a heterozygous mutant PEX6 allele (c.2578C>T [p.Arg860Trp]
135                                              Heterozygous mutant plants showed no visible leaf phenot
136 d whether phenotypes are also present in the heterozygous-mutant populations that comprise the vast m
137                                 Selfing of a heterozygous mutant produced normal-sized and shrunken s
138                            We found that pnr heterozygous mutants result in defective cardiac perform
139 ors and a maximum lifespan of 22 days, while heterozygous mutants (RL/+) exhibit autistic-like behavi
140 ient for the Bloom's syndrome helicase, such heterozygous mutants segregate homozygous daughter cells
141 e extreme fertility observed in the compound heterozygous mutant sheep.
142                                              Heterozygous mutants show a slow onset of degeneration i
143                                 In contrast, heterozygous mutants show an exaggerated escape response
144                             We conclude that heterozygous mutants show neither a molecular nor a phys
145                                          The heterozygous mutants showed slower growth kinetics and e
146 ice had no detectable CuZn-SOD activity, and heterozygous mutants (Sod1 +/-) showed a 50% decrease co
147  further suggestive of selection against the heterozygous mutant state as tumors progress.
148 We obtained homozygous cells from 40% of the heterozygous mutants tested.
149                          Moreover, in double heterozygous mutants, the lower incisors were consistent
150 00(DeltaKASH), or in klar and msp-300 double heterozygous mutants, the MSP-300 nuclear ring and the a
151                                              Heterozygous mutant thymocytes had a severe defect in p5
152 nctionally complemented lpat2 in transformed heterozygous mutants to produce the lpat2/lpat2 genotype
153                         We have grown > 6000 heterozygous mutants together and exposed them to a star
154                                 Using double heterozygous mutants, we also show that CaGPI2 and CaGPI
155                                          The heterozygous mutants were born with no pancreatic phenot
156                      By flow cytometry, some heterozygous mutants were polyploid accumulating >4 N DN
157                               Notch2(Q2319X) heterozygous mutants were smaller and had shorter femurs
158 ty could be rescued by transformation of the heterozygous mutant with a 35S:LPAAT1 construct.
159                                 In ephrin-B1 heterozygous mutants, X inactivation generates ephrin-B1
160                                  Breeding of heterozygous mutants yielded a normal Mendelian ratio am

 
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