ライフサイエンスコーパス: hiPSC

1 hiPSC-CMs cultured on Matrix Plus mature functionally an

2 hiPSCs are induced into incipient mesoderm-like cells (i

3 hiPSCs, neural precursor cells, and cortical neurons der

4 Overall, this study demonstrated that Wk-4 hiPSC-CMs showed improved functional, metabolic and ultr

5 Here, we report the generation of a hiPSC TBX5(Clover2) and NKX2-5(TagRFP) double reporter t

6 We present a hiPSC transcriptomics resource on corticogenesis from 5

7 AD hiPSC-derived neurons also displayed increased sodium cu

8 In the AD hiPSC-derived neurons/organoids, we found increased exci

9 on Paper: Integrating CRISPR Engineering and hiPSC-Derived 2D Disease Modeling Systems, by Kristina R

10 ts, and integration of advanced genetics and hiPSC-based datasets in future studies.

11 ble similarities between the BRV of hESC and hiPSC derived cardiomyocytes in vitro and the HRV in viv

12 y points out the great potential of hESC and hiPSC derived tissue to be used routinely for many diffe

13 beating cardiomyocytes derived from hESC and hiPSC was generally consistent with clinical experiences

14 induced pluripotent stem cells (hiPSCs) and hiPSC-CMs by employing xCGE-LIF.

15 sed in both mouse ventricular myocardium and hiPSC-CMs, while it was almost undetectable in canine ve

16 Explants and hiPSCs were then pulsed with BET inhibitors to increase

17 eating cardiomyocytes derived from hESCs and hiPSCs were made using Microelectrode Arrays (MEA).

18 perimental set with RPE derived from another hiPSC source and from foetal human RPE.

19 o estimate how much I(K1) is needed to bring hiPSC-CMs to a stable and hyperpolarized RMP and which m

20 ignaling bioactivity of exosomes released by hiPSC-derived neural cultures lacking MECP2, a model of

21 and allows the early screening of candidate hiPSC seed stocks for clinical use by facilitating safet

22 pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) CACNA1C-p.R518C model, CACNA1C-p.R518C hiPSC-C

23 pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) technology and by contact-free all-optical sys

24 n healthy human iPSC-derived cardiomyocytes (hiPSC-CM) and in developing Drosophila and zebrafish hea

25 contraction of hiPSC-derived cardiomyocytes (hiPSC-CMs) and implemented these signals to nonlinear an

26 luripotent-stem-cell-derived cardiomyocytes (hiPSC-CMs) and MAP4K4 gene silencing, we demonstrate tha

27 uripotent stem cells derived cardiomyocytes (hiPSC-CMs) are a virtually endless source of human cardi

28 luripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as tissue transplants in regenerative medicin

29 luripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have been developed for cardiac cell transpla

30 luripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in vitro can expand CMs modestly (<5-fold).

31 luripotent stem cell derived cardiomyocytes (hiPSC-CMs) is a major limitation to the use of these val

32 luripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide an excellent platform for potential c

33 luripotent stem cell derived cardiomyocytes (hiPSC-CMs) using CRISPR-Cas9.

34 luripotent stem cell-derived cardiomyocytes (hiPSC-CMs) with a haploinsufficient mutation for lamin A

35 luripotent stem cell-derived cardiomyocytes (hiPSC-CMs), and we describe responses to metabolic and p

36 luripotent stem cell-derived cardiomyocytes (hiPSC-CMs), but potentiated I(to) in the canine cardiomy

37 ction) control hiPSC-derived cardiomyocytes (hiPSC-CMs).

38 luripotent stem-cell-derived cardiomyocytes; hiPSC-CMs) at ~kHz with a sorting purity and recovery ra

39 anced ensemble stacking, clearly categorized hiPSCs in different developmental stages with 97.5% accu

40 CD49f(+) hiPSC-astrocytes are thus a valuable resource for invest

41 Notably, CD49f(+) hiPSC-astrocytes respond to inflammatory stimuli, acquir

42 and bulk transcriptome analyses of CD49f(+) hiPSC-astrocytes and demonstrate that they perform key a

43 SC) und human induced pluripotent stem cell (hiPSC) derived cardiomyocytes by analyzing the beat rate

44 lthough human induced pluripotent stem cell (hiPSC) lines are karyotypically normal, they retain the

45 Human induced pluripotent stem cell (hiPSC) lines from an individual with microphthalmia caus

46 pecific human-induced pluripotent stem cell (hiPSC) model of the SQTS, and to provide mechanistic ins

47 gy in a human induced pluripotent stem cell (hiPSC)-based in vitro model of neuroinflammation is demo

48 oupling human induced pluripotent stem cell (hiPSC)-based technology with CRISPR-based genome enginee

49 tes and human induced pluripotent stem cell (hiPSC)-derived astrocytes.

50 Human induced pluripotent stem cell (hiPSC)-derived blood-brain barrier (BBB) models establis

51 eity of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs).

52 pecific human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes and to identify physiologi

53 rs with human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes is a new paradigm for prec

54 tion of human induced pluripotent stem cell (hiPSC)-derived human intestinal organoids (HIOs) would f

55 Human-induced Pluripotent Stem Cell (hiPSC)-derived models have advanced the study of neurode

56 lity of human induced pluripotent stem cell (hiPSC)-derived monolayer brain cells and region-specific

57 sh that human induced pluripotent stem cell (hiPSC)-derived neurons well represent the diversity of N

58 esis in human induced pluripotent stem cell (hiPSC)-derived neuroprogenitors using an isotopically la

59 tity of human induced pluripotent stem cell (hiPSC)-derived RPE (iRPE) was extensively characterized,

60 derived human induced pluripotent stem cell (hiPSC)-RPE cells from an individual carrying a homozygou

61 d from human induced pluripotent stem cells (hiPSC) at the physiological air-liquid interface (ALI) r

62 tional human induced pluripotent stem cells (hiPSC) can be significantly improved by reversion to a t

63 s from human induced pluripotent stem cells (hiPSC-CMs) are increasingly recognized as valuable for d

64 derived from induced pluripotent stem cells (hiPSC-CMs) from Danon patients exhibit decreased colocal

65 -culture of human induced pluripotent cells (hiPSCs) with various types of supporting non-parenchymal

66 Human-induced pluripotent stem cells (hiPSCs) allow for the establishment of brain cellular mo

67 ion of human induced pluripotent stem cells (hiPSCs) and hiPSC-CMs by employing xCGE-LIF.

68 Human induced pluripotent stem cells (hiPSCs) and neurons derived from them are documented as

69 Human induced pluripotent stem cells (hiPSCs) are a powerful model of neural differentiation a

70 d from human induced pluripotent stem cells (hiPSCs) are ideal for developing patient-specific cell t

71 d from human induced pluripotent stem cells (hiPSCs) are one such in vitro model.

72 s) and human induced pluripotent stem cells (hiPSCs) can rapidly produce high-yield excitatory neuron

73 ) from human induced pluripotent stem cells (hiPSCs) derived from an LCA4 patient carrying a Cys89Arg

74 w that human induced pluripotent stem cells (hiPSCs) derived from DS patients overproduce OLIG2(+) ve

75 s from human induced pluripotent stem cells (hiPSCs) for producing tissue-engineered vascular grafts

76 ent of human-induced pluripotent stem cells (hiPSCs) has made possible patient-specific modeling acro

77 Human induced pluripotent stem cells (hiPSCs) have a number of potential applications in stem

78 erived human induced pluripotent stem cells (hiPSCs) have demonstrated considerable promise in consti

79 Human induced pluripotent stem cells (hiPSCs) have revolutionized research on human diseases,

80 ecific human-induced pluripotent stem cells (hiPSCs) hold great promise for the modelling of genetic

81 tiated human induced pluripotent stem cells (hiPSCs) into NPCs to generate two-dimensional (2D) and t

82 ntiate human induced pluripotent stem cells (hiPSCs) into oogonia in vitro.

83 Cs) or human induced pluripotent stem cells (hiPSCs) is a promising approach to model the complex str

84 ) from human induced pluripotent stem cells (hiPSCs) is critically dependent upon the regulation of t

85 d from human induced pluripotent stem cells (hiPSCs) of ASD individuals with early developmental brai

86 d with human induced pluripotent stem cells (hiPSCs) or hiPSCs overexpressing the antiapoptotic facto

87 Human induced pluripotent stem cells (hiPSCs) provide a potentially unlimited cell source for

88 Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease modeling

89 d from human induced pluripotent stem cells (hiPSCs) provide the capability of identifying biological

90 d from human induced pluripotent stem cells (hiPSCs) still lack a microglia component, the resident i

91 lly engineered human pluripotent stem cells (hiPSCs) that captures authentic cancer pathobiology.

92 ned in human induced pluripotent stem cells (hiPSCs) that were differentiated either to lateral plate

93 ployed human induced pluripotent stem cells (hiPSCs) to compare patterns of Abeta42 accumulation in H

94 ployed human induced pluripotent stem cells (hiPSCs) to model acute and latent HSV-1 infections in tw

95 ployed human induced pluripotent stem cells (hiPSCs) to model the interaction of HSV-1 with NPCs, whi

96 d from human induced pluripotent stem cells (hiPSCs) via ribosome profiling.

97 nes of human induced pluripotent stem cells (hiPSCs) were generated from 13 individuals with 16p11.2

98 nts in human induced pluripotent stem cells (hiPSCs), and develop a software package (rgenie) to anal

99 les in human induced pluripotent stem cells (hiPSCs), indicating isoform-specific function.

100 3T and human induced pluripotent stem cells (hiPSCs), respectively, three orders of magnitude greater

101 as9 in human induced pluripotent stem cells (hiPSCs), we efficiently create pathogenic deletion mutat

102 erived human induced pluripotent stem cells (hiPSCs), we found that in patients protected from CVD, t

103 ts and human induced pluripotent stem cells (hiPSCs), we show that BET protein inhibition with I-BET1

104 ively, human induced pluripotent stem cells (hiPSCs), which are expandable in culture and have the po

105 ulated human induced pluripotent stem cells (hiPSCs).

106 y from human induced pluripotent stem cells (hiPSCs).

107 s from human induced pluripotent stem cells (hiPSCs).

108 levant human induced pluripotent stem cells (hiPSCs).

109 production of non-immunogenic, cellularized hiPSC-derived TEVGs composed of allogenic vascular cells

110 We compare hiPSCs bearing familial AD mutations vs. their wild-type

111 s recent advances in generating more complex hiPSC-based systems using three-dimensional organoids, t

112 Based on these results, mutant and control hiPSC cultures were treated exogenously with selected FG

113 A-seq), the authors compared DMD and control hiPSC-derived cardiomyocytes, mdx mice, and control mice

114 ISPR/Cas9-based mutation correction) control hiPSC-derived cardiomyocytes (hiPSC-CMs).

115 decrease neuronal activity levels in control hiPSC-neurons.

116 compared with the patient's isogenic control hiPSC-CMs (434+/-30 ms; n=8; P<0.05).

117 622+/-11 ms; n=92) than the isogenic control hiPSC-CMs (453+/-5 ms; n=62; P<0.0001).

118 iPSC-CMs when compared with isogenic control hiPSC-CMs.

119 Q)VSX2 hiPSC-OVs relative to sibling control hiPSC-OVs.

120 ever, antagonizing FGF9 in wild-type control hiPSCs did not alter OV development.

121 l polarization in human neurons, we cultured hiPSC-derived neurons, characterized early developmental

122 Co-culturing hiPSCs with human endothelial cells (hECs) is a relative

123 capitulated by LAMP-2B knockout in non-Danon hiPSC-CMs.

124 iring, whereas exosomes from MECP2-deficient hiPSC neural cultures lack this capability.

125 -derived cardiomyocytes from HADHA-deficient hiPSCs and accelerated their maturation via an engineere

126 The developed hiPSC-based RoC has the potential to promote drug develo

127 We developed hiPSC-derived Aged dopaminergic and cholinergic neurons

128 cing SynGAP protein expression in developing hiPSC-derived neurons enhanced dendritic morphogenesis,

129 ntiated from patient-specific naive diabetic hiPSC (N-DhiPSC) possessed higher vascular functionality

130 culture method (EECM), which differentiates hiPSC-derived endothelial progenitor cells to brain micr

131 e tissue level using confluent 2-dimensional hiPSC-derived cardiac cell sheets (hiPSC-CCSs) and optic

132 e strongest risk factor for these disorders, hiPSC-derived models represent rejuvenated neurons.

133 ne and following adrenergic stimulation, DMD hiPSC-derived cardiomyocytes had a significant increase

134 MD left ventricle samples and found that DMD hiPSC-derived cardiomyocytes have dysregulated pathways

135 ilenced by a designer drug while using donor hiPSC-MGE cells expressing designer receptors exclusivel

136 As a result, DS hiPSC-derived cerebral organoids excessively produce spe

137 easurement of hundreds of sarcomeres in each hiPSC-CM, SarcTrack provides large data sets for robust

138 nd FGF19 were selectively increased in early hiPSC-derived optic vesicles (OVs) when compared to isog

139 Our findings establish hiPSC-derived AD neuronal cultures and organoids as a re

140 atial factors that regulate Wnt, we evaluate hiPSC-CM differentiation with: (1) two-phase modulation

141 Engineered heart tissues from expanded hiPSC-CMs showed comparable contractility to those from

142 Taken together, we introduce the first hiPSC-derived BBB model that displays an adhesion molecu

143 n neglected as potential surface markers for hiPSC-CMs due to significant analytical challenges.

144 LC (hLC) features supports the potential for hiPSC-based hLC regeneration.

145 rds identifying a subset of 'footprint'-free hiPSC clones.

146 ferentiation efficiency and consistency from hiPSC lines to CMs.

147 Data from hiPSC phenotypes and human embryonic stem cells (hESCs)

148 rt development of engineered VF mucosae from hiPSC, transfected via TALEN constructs for green fluore

149 of the neural progenitor cells derived from hiPSCs that have been genome-edited to contain tumor-ass

150 tudy, microglia-like cells were derived from hiPSCs using a simplified protocol with stage-wise growt

151 n a human neuroprogenitor model derived from hiPSCs, but endosulfan sulfate and tributyltin chloride

152 nt essential retinal cell types derived from hiPSCs.

153 primary VSMCs and VSMCs differentiated from hiPSCs and observed that the number of lipid droplets wa

154 e-dimensional (3D) brain organoids made from hiPSCs to model HSV-1-human-CNS interactions.

155 itotic maturation of human neurons made from hiPSCs, which influences how activity develops within na

156 ol to generate choroid plexus organoids from hiPSCs and showed that productive SARS-CoV-2 infection o

157 ngineer brain region-specific organoids from hiPSCs incorporated with isogenic microglia-like cells i

158 The success in generating hiPSC-derived hLLCs with broad human LC (hLC) features s

159 ss advances at the intersection of genomics, hiPSCs and CRISPR.

160 relevant quality controls for clinical-grade hiPSCs remain imperative.

161 ant human leucocyte antigen (HLA)-homozygous hiPSCs and their derivatives under postdistribution cond

162 However, hiPSC-derivatives have traditionally been utilized in tw

163 However, hiPSC-derived TEVGs are hampered by low mechanical stren

164 We also report that human hiPSC-derived cardiomyocytes possess measurable TRPM7 cu

165 We also report that human hiPSC-derived cardiomyocytes possess measurable TRPM7 cu

166 Our results show that (i) hiPSC-derived CNS neurons are permissive for HSV-1 infec

167 NA (miRNA) profiling at Wk-1, Wk-2 & Wk-4 in hiPSC-CMs in vitro.

168 tochondrial function, and calcium cycling in hiPSC-CMs.

169 t with VSX2 to promote NR differentiation in hiPSC-OVs and has potential to be used to manipulate ear

170 As proof of principle that drug discovery in hiPSC-CMs may predict efficacy in vivo, DMX-5804 reduces

171 tly, targeted deletion of ESRRA and ESRRG in hiPSC-CM derepressed expression of early (transcription

172 ribed in animal models can be established in hiPSC-derived CNS neurons; (iii) the complex laminar str

173 ara I(K1) model to perform DC experiments in hiPSC-CMs.

174 oward the simple gangliosides GM3 and GD3 in hiPSC-CMs.

175 tified 454 differentially expressed genes in hiPSC-derived neurons, enriched in pathways including ph

176 e contraction, are immature and nonlinear in hiPSC-CMs, which technically challenge accurate function

177 ntagonized the I(to) inhibition by NS5806 in hiPSC-CMs.

178 tations when translating results obtained in hiPSC-CMs to humans, and 3) shows the strength of combin

179 monitors fluorescently tagged sarcomeres in hiPSC-CMs.

180 In hiPSCs, BET inhibitors strongly repressed C-peptide and

181 In hiPSCs, the outcome was different because C-peptide expr

182 BN V388I mutation or SALL4 G416A mutation in hiPSCs.

183 fic embryonic antigen 3 (SSEA3) and SSEA4 in hiPSCs toward the simple gangliosides GM3 and GD3 in hiP

184 and pomalidomide, dose-dependently inhibited hiPSC mesendoderm differentiation.

185 An isogenic hiPSC-CM gene-corrected control was created using CRISPR

186 Characterization of isogenic hiPSC-derived neurons using heterochromatin and nuclear

187 After readthrough drug treatment, the LCA16 hiPSC cells were hyperpolarized by 30 mV, and the Kir7.1

188 We found that the LCA16 hiPSC-RPE cells had normal morphology but did not expres

189 vailable induced pluripotent stem cell line (hiPSC) obtained from a human female donor.

190 d human induced pluripotent stem cell lines (hiPSCs) and demonstrate physiological permeability of Lu

191 d a molecular interplay that enables massive hiPSC-CM expansion for large-scale drug screening and ti

192 Mature hiPSC-CMs showed rod-shaped morphology, highly organized

193 Matrix Plus also promoted mature hiPSC-CM electrophysiological function and monolayers' r

194 terol biosynthesis and that methodologically hiPSC neuroprogenitor cells provide a particularly sensi

195 lowing implantation into a rat aortic model, hiPSC-derived TEVGs show excellent patency without lumin

196 Genetically modified hiPSCs expressing CRBN E377V/V388I mutant or SALL4 G416A

197 Compared with gene-corrected cells, mutant hiPSC-CMs have marked electrophysiological and contracti

198 n most gene expression alterations in mutant hiPSC-CMs.

199 ripotent stem cell-derived cardiac myocytes (hiPSC-CM) demonstrated that ERRgamma activates transcrip

200 tankyrase inhibitor-regulated naive hiPSC (N-hiPSC) represent a class of human stem cells with high e

201 broadly, tankyrase inhibitor-regulated naive hiPSC (N-hiPSC) represent a class of human stem cells wi

202 A novel hiPSC-based model of the SQTS was established at both th

203 ronal activity in patient-derived NRXN1(+/-) hiPSC-neurons is ameliorated by overexpression of indivi

204 Patient-derived NRXN1(+/-) hiPSC-neurons show a greater than twofold reduction in h

205 Using this protocol, we obtain hiPSC colonies (up to 160 +/- 20 mean +/- s.d (n = 48))

206 Optically obtained hiPSC-CM APs and CaTrs were used from spontaneous activi

207 SarcTrack analysis of hiPSC-CMs carrying a heterozygous truncation variant in

208 Functional assessment of hiPSC-CMs was determined by multielectrode array (MEA),

209 The combination of hiPSC-based disease modeling, CRISPR technology, and hig

210 forms reflecting the physical contraction of hiPSC-derived cardiomyocytes (hiPSC-CMs) and implemented

211 (OVs) when compared to isogenic cultures of hiPSC-derived forebrain neurospheres.

212 l was developed to refine the description of hiPSC-CM spontaneous electrical activity; a population o

213 critical power limitations in the design of hiPSC-based studies of complex genetic disorders.

214 tocol based on a combined differentiation of hiPSC in 2D cultures followed by a forced reaggregation

215 ges associated with functional evaluation of hiPSC-CMs, SarcTrack enhances translational prospects fo

216 Here, we demonstrate massive expansion of hiPSC-CMs in vitro (i.e., 100- to 250-fold) by glycogen

217 ng these three critical physical features of hiPSC-CMs allows identification of all major drug classe

218 Here, we report generation of hiPSC-derived TEVGs with mechanical strength comparable

219 a rat model, we demonstrate that grafting of hiPSC-derived MGE-like interneuron precursors into the h

220 Moreover, grafting of hiPSC-MGE cells after SE mediated several neuroprotectiv

221 ynaptic function and network interactions of hiPSC-derived neurons.

222 In monolayers of hiPSC-CMs, we simultaneously monitored voltage and Ca(2+

223 Our work illustrates the power of hiPSC differentiation to unveil long-range pathomechanis

224 ution to the commonly encountered problem of hiPSC-CM immaturity that has hindered implementation of

225 in HLHS through single-cell RNA profiling of hiPSC-derived endocardium and human fetal heart tissue w

226 physiology by engaging in the regulation of hiPSC transcription in an isoform-specific manner, provi

227 mechanism of Wnt activation in regulation of hiPSC-CMs differentiation, and more importantly provide

228 advance the reproducibility and relevance of hiPSC-based studies, stem cell biologists must contempla

229 mexiletine via high-throughput screening of hiPSC-CMs derived from patients with the cardiac rhythm

230 the hypothesis of that fate specification of hiPSC-CMs differentiation is dictated by temporal and sp

231 n vitro MEA based platforms for the study of hiPSC neural network activity and their potential use in

232 nducted an RNA-sequencing profiling study of hiPSC-derived cell lines from schizophrenia (SCZ) subjec

233 e substantive evidence of the suitability of hiPSC-based neuronal platforms to model HSV-1-CNS intera

234 ogical assays can be complex, and the use of hiPSC-cardiomyocyte models of congenital disease phenoty

235 RS-CoV-2 neurotropism and support the use of hiPSC-derived brain organoids as a platform to investiga

236 diac cell death and highlight the utility of hiPSC-CMs in drug discovery to enhance cardiomyocyte sur

237 our results highlight the potential value of hiPSC-derived 3D cultures to model HSV-1-NPC interaction

238 successfully induced the differentiation of hiPSCs into either human Leydig-like (hLLCs) or adrenal-

239 proteome during stepwise differentiation of hiPSCs into HLCs over 40 days.

240 This system also enables the generation of hiPSCs suitable for clinical translation or further rese

241 f the regulation of autophagy, generation of hiPSCs via cellular reprogramming, and neuronal differen

242 While demonstrating the utility of hiPSCs derived from multiplex families to identify signi

243 siological and immunofluorescence studies on hiPSC-derived cerebrocortical neuronal cultures and cere

244 for understanding the confinement effects on hiPSCs differentiation while confirming its importance f

245 n induced pluripotent stem cells (hiPSCs) or hiPSCs overexpressing the antiapoptotic factor BCL2, tra

246 bitors on synchronous firing patterns of our hiPSC-derived neural networks.

247 in late-passage hiPSCs than in early-passage hiPSCs after differentiation.

248 entiation ability of early- and late-passage hiPSCs into cardiomyocyte-like, hepatic-like, and neuron

249 in which more SNPs occurred in late-passage hiPSCs than in early-passage hiPSCs after differentiatio

250 udy aimed to (i) explore whether the patient hiPSC-derived ROs recapitulate LCA4 disease phenotype, a

251 across multiple genetic and pharmacological hiPSC-CM models of LQT3 with diverse backgrounds.

252 d a mechanical stretching regimen to produce hiPSC-derived TEVGs with mechanical behavior similar to

253 derived extracellular matrix (ECM) promotes hiPSC-CM maturation to a greater extent than mouse cell

254 e consistent and high-yield and high-quality hiPSC-CMs production in cardiovascular research.

255 Patch clamp assessment of CACNA1C-p.R518C hiPSC-CMs paced at 1 Hz confirmed a prolonged APD(90) (6

256 Arclight-measured APD(90) of CACNA1C-p.R518C hiPSC-CMs was significantly longer (622+/-11 ms; n=92) t

257 C-CM) CACNA1C-p.R518C model, CACNA1C-p.R518C hiPSC-CMs were generated from a 13-year-old man (QTc, >4

258 sed late calcium current for CACNA1C-p.R518C hiPSC-CMs when compared with isogenic control hiPSC-CMs.

259 We review recent hiPSC-based models of SZ, in light of our new understand

260 mensional hiPSC-derived cardiac cell sheets (hiPSC-CCSs) and optical mapping.

261 ughput experimental data to refine in silico hiPSC-CM populations and to predict and explain drug act

262 ectrical activity; a population of in silico hiPSC-CMs was constructed and calibrated using simultane

263 mentally calibrated populations of in silico hiPSC-CMs, 2) offers insights into certain limitations w

264 Using patient-specific hiPSC-CM mutant and isogenic control lines, we demonstra

265 pathy, the authors used DMD patient-specific hiPSC-derived cardiomyocytes to examine the physiologica

266 e-associated aberrations in patient-specific hiPSC.

267 Patient-specific hiPSCs were generated from a symptomatic SQTS patient ca

268 Using patient-specific hiPSCs, we show that, although the inversion shuffles th

269 Optical mapping of the SQTS-hiPSC-CCSs revealed shortened APD, impaired APD-rate ada

270 nd abbreviated refractory period in the SQTS-hiPSC-CMs.

271 Collectively, our results demonstrate that hiPSC-derived VF mucosa is a versatile tool for future i

272 Collectively, our results indicate that hiPSC-derived neuronal platforms, especially 3D organoid

273 We propose that hiPSC models may be useful for screening drugs to treat

274 Here, we show that hiPSC-derived NPCs from ASD individuals with macrocephal

275 In order to establish the hiPSC-CM-based platform as an autologous source for card

276 APD(50)/APD(90)) after including them in the hiPSC-CM mathematical model by Paci.

277 nction after lentiviral gene delivery to the hiPSC-RPE cells.

278 sistently better performance compared to the hiPSCs only group in regard to persistent albumin secret

279 l neural progenitor cells derived from these hiPSCs identified alterations in gene expression pattern

280 phenotypes-and how this might emerge through hiPSC-based studies.

281 Thus, hiPSCs-derived microglia transplanted into the neonatal

282 c action in adult cardiomyocytes compared to hiPSC-CMs could be traced to the different expression of

283 interested in translating their research to hiPSC-based studies.

284 protocol to reprogram human somatic cells to hiPSCs with high efficiency in 15 d using microfluidics.

285 alidated SarcTrack by analyzing drug-treated hiPSC-CMs, confirming the contractility effects of compo

286 three congruent patient-specific cell types-hiPSCs, hESCs and direct-lineage-converted cells-derived

287 rable contractility to those from unexpanded hiPSC-CMs, demonstrating uncompromised cellular function

288 Recently in Cell, Lo Sardo et al. used hiPSC genome editing to demonstrate how this locus contr

289 easibility of studying alveolar repair using hiPSC-AEC2 cultured at the ALI and indicated that this m

290 rders where autophagy has been studied using hiPSC models.

291 Multiple studies have utilized hiPSC models of neurodegenerative diseases to study auto

292 mutant retinal phenotype of the (R200Q)VSX2 hiPSC-OV model.

293 were downregulated over time in (R200Q)VSX2 hiPSC-OVs relative to sibling control hiPSC-OVs.

294 While hiPSC differentiation still requires optimization, these

295 ration of CRISPR engineering approaches with hiPSC-based models permits precise isogenic comparisons

296 Co-culture of EECM-BMEC-like cells with hiPSC-derived smooth muscle-like cells or their conditio

297 Microvascular Endothelial Cells (HAMEC) with hiPSCs, leading to a higher differentiation yield and no

298 The WT hiPSC-CMs did not exhibit any sign of arrhythmogenicity

299 ot include all n = 6 samples for the hESC, Y-hiPSC and AG4-ZSCAN10 groups as was stated in the legend

300 In addition, the bars for hESC, Y-hiPSC, AG4-ZCNAN10, AG4 and LS in Supplementary Fig.