ライフサイエンスコーパス: hibernate

1 squirrels before any of the animals began to hibernate.

2 utside of Madagascar was previously known to hibernate.

3 Toolkit, and server-side data storage using Hibernate.

4 axis, increases its body weight, and finally hibernates.

5 The bacterial hibernating 100S ribosome is a poorly understood form of

6 Bacterial hibernating 100S ribosomes (the 70S dimers) are excluded

7 584 segments, 24% (n = 140) were labeled as hibernating; 23% (n = 136) as stunned; 30% (n = 177) as

8 mine, was observed in 83% of stunned, 59% of hibernating, 35% of remodeled and 13% of scarred myocard

9 l because only 55% of segments classified as hibernating actually improved resting function after rev

10 Ascorbate levels in the CSF doubled in hibernating AGS (not determined in TLS), while brain asc

11 osmolarity and pH outside the incubator with Hibernate and density gradient separation of neurons fro

12 n where parasite dispersal and mating occur, hibernate and infect the next generation of wasp larvae.

13 -altitude inhabitants, as well as those that hibernate and interrupt their development when exposed t

14 but kinase-knockout clones still are able to hibernate and recover, indicating that this pathway does

15 me, and hematological features of blood from hibernating and active free-ranging subadult brown bears

16 The brain tissue from hibernating and euthermic animals was examined 3 days af

17 utyric acid ([GABA](ecf)) in striatum of non-hibernating and hibernating arctic ground squirrels to t

18 se-3-like activity was not different between hibernating and summer kidneys.

19 nconsistent bloodstream amino acid supply by hibernating and waiting for more nutrient to be provided

20 d by fibrosis from that arising from viable (hibernating and/or stunned) myocardium has important imp

21 ptable mammals, spending up to half the year hibernating, and the remainder of the year attempting to

22 It may also be induced in nonhibernators via hibernating animal serum factors or delta-opiate peptide

23 emical findings were compared with untreated hibernating animals (n = 7), sham-normal animals (n = 5)

24 amatically attenuated around probe tracks in hibernating animals compared to euthermic controls.

25 respect from nature: Diving, burrowing, and hibernating animals living in diverse environments are m

26 similarities between calorie-restricted and hibernating animals suggest the effects of CR may be par

27 shutdown of cellular functions that permits hibernating animals to tolerate severe reductions in cer

28 Kidneys from both summer and hibernating animals tolerated ex vivo CI, confirming tha

29 SCs were observed postsynaptic to cones from hibernating animals, although depolarized cones were abl

30 ernation confers radio-protective effects in hibernating animals, and this has led to the investigati

31 mans are lacking, several reports, mainly on hibernating animals, demonstrated that melatonin supplem

32 An uncharacterized factor derived from hibernating animals, hibernation induction trigger (HIT)

33 34 interactions were disrupted in brain from hibernating animals, in which eIF-2alpha was highly phos

34 imer-like phosphorylation is also present in hibernating animals, mitosis, or during embryonic develo

35 In hibernating animals, reduction of immunoreactive phospho

36 tolerance to cerebral ischemia exhibited by hibernating animals.

37 earch and conservation strategies to benefit hibernating animals.

38 BA](ecf)) in striatum of non-hibernating and hibernating arctic ground squirrels to test the hypothes

39 neural microstructure from groups of animals hibernating at different ambient temperatures revealed t

40 Millions of hibernating bats across North America have died from whi

41 Population estimates of hibernating bats are often calculated by researchers ent

42 ose syndrome (WNS) is an emerging disease of hibernating bats associated with cutaneous infection by

43 drome (WNS) is an emerging disease affecting hibernating bats in eastern North America that causes ma

44 We show, in hibernating bats infected with Geomyces destructans, tha

45 ts a pronounced northward range expansion of hibernating bats within the next 80 years.

46 activity increased with increasing number of hibernating bats, but more so for western small-footed m

47 proliferates at low temperatures and targets hibernating bats, resulting in their premature arousal f

48 s (Pd) has killed millions of North American hibernating bats.

49 uctans on the skin (including the muzzle) of hibernating bats.

50 cal response to disuse and malnutrition, but hibernating bears are largely resistant to this phenomen

51 In contrast, hibernating bears show no bone loss over the prolonged p

52 on and delayed recovery of metabolic rate in hibernating bears suggest that the majority of metabolic

53 hat fast during lactation, such as seals and hibernating bears.

54 f bone formation and osteoblast signaling in hibernating bears.

55 w temperatures, and perhaps their ability to hibernate below the permafrost, might explain the abilit

56 murs of Madagascar are obligate hibernators, hibernating between 3 and 7 months a year.

57 sured metabolic rate and body temperature in hibernating black bears and found that they suppress met

58 Administration of serum derived from hibernating black bears to rabbits affords protection ag

59 ranscription-PCR products from euthermic and hibernating brain and compared them using differential d

60 as reduced 3-fold in cell-free extracts from hibernating brain at 37 degreesC, eliminating hypothermi

61 rpose of this study was to determine whether hibernating brain tissue is tolerant to penetrating brai

62 of the catalytic subunit of PP2A (PP2A/C) in hibernating brains and livers.

63 oxically, long-term immobilized free-ranging hibernating brown bears and paralyzed spinal cord injury

64 an antithrombotic signature in platelets of hibernating brown bears with heat shock protein 47 (HSP4

65 Among patients with ischemic cardiomyopathy, hibernating, but not ischemic, myocardium identifies whi

66 Hibernating cardiomyocytes are reversibly hypocontractil

67 illustrate a predominant use of the site by hibernating cave bears and denning hyaenas, coupled with

68 eds of thousands of individual RBCs from the hibernating common noctule bat (Nyctalus noctula), the n

69 approximately 124% and 99%, respectively, in hibernating compared with cold control preparations with

70 The remaining SCNx squirrels that did not hibernate continuously displayed CARs in body mass withi

71 ether animals prepare to develop, reproduce, hibernate, enter dormancy, or migrate.

72 RNAP-delta-HelD)(2) structure that resembles hibernating eukaryotic RNAP I suggest that HelD might al

73 Thus, the torpid/awakening cycle of the hibernating European hamster causes a rapid and reversib

74 Black bears hibernate for 5 to 7 months a year and, during this time

75 Brown bears (Ursus arctos) hibernate for 5-7 months without eating, drinking, urina

76 Unlike normal squirrels that hibernate for about 6 months during each circannual cycl

77 ts during the migratory season and sometimes hibernate for an entire winter.

78 Western fat-tailed dwarf lemurs are known to hibernate for seven months per year inside tree holes.

79 Furthermore, bears that hibernated for shorter periods of time experienced accel

80 that bears that foraged more on human foods hibernated for shorter periods of time.

81 rrels that did not hibernate or had not been hibernating for several weeks.

82 one of euthermic (control), cold control and hibernating golden hamsters.

83 ignaling are regulated in skeletal muscle of hibernating grizzly bear.

84 Isolated hibernating ground squirrel and mouse RTECs were subject

85 d for weeks in brain and other organs of the hibernating ground squirrel, Spermophilus tridecemlineat

86 uirrels (T(b) range 34.7-38.9 degrees C) and hibernating ground squirrels (T(b) range 2.9-3.9 degrees

87 BA](ecf) was determined in unrestrained, non-hibernating ground squirrels (T(b) range 34.7-38.9 degre

88 , suggest that light can reach the retina of hibernating ground squirrels maintained in the laborator

89 rites, and spines from several cell types in hibernating ground squirrels retract on entry into torpo

90 ng hibernation and arousal in two species of hibernating ground squirrels suggest that it could play

91 d shutdown of cellular function that permits hibernating ground squirrels to tolerate "trickle" blood

92 bular epithelial cells (RTECs) isolated from hibernating ground squirrels would be protected against

93 eriments, we looked at mlEPSCs from cones of hibernating ground squirrels, which exhibit dramatically

94 -2) was observed in the brains and livers of hibernating ground squirrels.

95 everal types of neurons in fixed slices from hibernating ground squirrels.

96 n cold controls and markedly enhanced in the hibernating group at all frequencies tested.

97 In the hibernating group, NTG alone improved wall thickening in

98 ificantly enhanced in both cold controls and hibernating groups, while vasoconstriction in response t

99 ificantly increased in the renal arteries of hibernating hamsters compared with controls, but not com

100 The ultrastructure of MFT in hibernating hamsters showed a significant reduction in s

101 y in the pancreas, but when expressed in the hibernating heart it liberates fatty acids from triglyce

102 val underlies the sustained viability of the hibernating heart.

103 on after revascularization in these areas of hibernating heart.

104 In hibernating hearts, icMSCs increased Ki67+ cardiomyocyte

105 y be related to the temperature range of its hibernating host.

106 teristics of the cardiac interstitium in the hibernating human myocardium and evaluate whether active

107 ular necrosis and apoptosis did not occur in hibernating kidneys.

108 g perfusion was significantly reduced in the hibernating LAD region in comparison with the normal rem

109 increased from 2.4+/-0.04 to 4.7+/-0.7 mm in hibernating LAD regions (P<0.05) whereas remote wall-thi

110 muscle of arctic ground squirrels, comparing hibernating (late in a torpor and during torpor re-entry

111 , we used convergent evolutionary changes in hibernating lineages to define conserved cis-regulatory

112 and a long-term (1976-2008) data set from a hibernating mammal (the yellow-bellied marmot) inhabitin

113 of the dynamics of the body temperature of a hibernating mammal is presented.

114 d cardiac ischemia but are well tolerated by hibernated mammalian myocardium.

115 Hibernating mammals are remarkable for surviving near-fr

116 shortage and/or reduced ambient temperatures hibernating mammals become heterothermic, allowing their

117 Torpor in hibernating mammals defines the nadir in mammalian metab

118 In contrast, hibernating mammals demonstrate limited muscle loss over

119 Neurons in hibernating mammals exhibit a dramatic form of plasticit

120 Hibernating mammals possess a unique ability to reduce t

121 Hibernating mammals survive for periods up to 6 mo in th

122 emonstrate that resting myosin is altered in hibernating mammals, contributing to significant changes

123 In hibernating mammals, cooling induces loss of synaptic co

124 ypothermic and hypometabolic torpid state in hibernating mammals, we investigated the potential for t

125 uction and energy expenditure in infants and hibernating mammals-also exists in adult humans.

126 has been shown to be cerebral protective in hibernating mammals.

127 Apoptotic myocytes were observed in the hibernating myocardial region in all pigs (4.8 +/- 2.3%)

128 vidence for a local inflammatory reaction in hibernating myocardial segments from patients undergoing

129 sion imaging detects impaired resting MBF in hibernating myocardial segments.

130 ly perfused remote regions from animals with hibernating myocardium (32+/-7%).

131 20+/-77 myocytes per 10(6) myocyte nuclei in hibernating myocardium (P<0.05).

132 nt in LVEF was associated with the volume of hibernating myocardium (viable myocardium with contracti

133 coronary artery (LAD) stenosis that produced hibernating myocardium after 3 months.

134 licits a gene program of survival protecting hibernating myocardium against cell death.

135 ibitory cytokines are elevated in regions of hibernating myocardium and account in part for the depre

136 GF-5 may afford a way to restore function in hibernating myocardium and ameliorate heart failure in c

137 renergic receptor densities occur in viable, hibernating myocardium and may account in part for the o

138 period (P<0.05 versus untreated animals with hibernating myocardium and normal shams).

139 Swine with hibernating myocardium arising from a chronic left anter

140 that can accurately determine the amount of hibernating myocardium as well as the presence and degre

141 re is evidence to suggest that patients with hibernating myocardium benefit most from revascularizati

142 coplasmic reticulum proteins were present in hibernating myocardium but absent in stunned myocardium

143 thickening at low-dose DSE may be limited in hibernating myocardium by severe hypoperfusion.

144 umented with a proximal LAD stenosis develop hibernating myocardium characterized by relative reducti

145 ysiological and molecular characteristics of hibernating myocardium develop rapidly after a critical

146 Hibernating myocardium developed a significant downregul

147 Previous studies have suggested that hibernating myocardium eventually results in progressive

148 proved clinically useful for distinguishing hibernating myocardium from irreversibly injured myocard

149 nuclear density to 995+/-100 nuclei/mm(2) in hibernating myocardium from the instrumented group versu

150 fter 2 weeks, when physiological features of hibernating myocardium had developed.

151 acked necrosis, might have been mistaken for hibernating myocardium had only histology been evaluated

152 rsibility of protein changes that develop in hibernating myocardium have an impact on functional reco

153 Although humans and swine with hibernating myocardium have an increased risk of sudden

154 al function and heart failure, dysfunctional hibernating myocardium improves after pravastatin.

155 Hibernating myocardium in patients with collateral-depen

156 ced flow and increased FDG characteristic of hibernating myocardium in similarly instrumented pigs af

157 Delayed recovery of hibernating myocardium in the absence of scar may reflec

158 Previous studies of hibernating myocardium in the fasting state have shown r

159 cyte >10%) and increased glycogen typical of hibernating myocardium in the LAD region (33+/-3% of myo

160 New modalities to detect hibernating myocardium include 99mTc-sestamibi, contrast

161 lts indicate that icMSCs improve function in hibernating myocardium independent of coronary flow or r

162 Several models purported to represent hibernating myocardium involve a coronary stenosis (CS)

163 The diagnosis of hibernating myocardium involves (a) documenting left ven

164 These data support the notion that hibernating myocardium is a pathophysiological substrate

165 Hibernating myocardium is a state of persistently impair

166 Hibernating myocardium is accompanied by a downregulatio

167 his study was performed to determine whether hibernating myocardium is adaptive or is destined to und

168 lation of oxygen consumption and function in hibernating myocardium is an adaptive response that prev

169 Hibernating myocardium is associated with persistent red

170 Hibernating myocardium is characterized by reduced regio

171 ata indicate that the proteomic phenotype of hibernating myocardium is dynamic and has similarities t

172 0.65+/-0.08 (mean+/-SEM) mL.min(-1).g(-1) in hibernating myocardium of instrumented pigs compared wit

173 F-A improves contractile function of chronic hibernating myocardium of pigs to a level comparable to

174 on tomography identified ischemia, scar, and hibernating myocardium on the survival benefit associate

175 Swine with chronic hibernating myocardium received autologous intracoronary

176 Hibernating myocardium refers to chronically dysfunction

177 Thus, physiologic and structural features of hibernating myocardium remain constant for at least two

178 ster and more precise method for determining hibernating myocardium remains the holy grail of noninva

179 , can be initiated by regional dysfunctional hibernating myocardium resulting from a severe coronary

180 in function and oxygen consumption at rest, hibernating myocardium retains the ability to increase m

181 and the presence of ischemia and/or stunned/hibernating myocardium should be assessed for optimal ma

182 designed to study apoptosis in hypoperfused hibernating myocardium subtending severe coronary stenos

183 tricular dysfunction (LVD) may have areas of hibernating myocardium that improve functionally after r

184 gene expression is regionally upregulated in hibernating myocardium to a level intermediate between t

185 te the serial changes in the response of the hibernating myocardium to dobutamine stimulation after r

186 is heterogeneous, varying from predominantly hibernating myocardium to irreversible scarring.

187 f contractile reserve and thallium uptake in hibernating myocardium to myocardial structure in humans

188 descending artery (LAD) stenosis to produce hibernating myocardium underwent percutaneous revascular

189 egion (33+/-3% of myocytes from animals with hibernating myocardium versus 15+/-4% of myocytes from s

190 ascularization in the setting of significant hibernating myocardium was associated with improved surv

191 Human hibernating myocardium was characterized by an upregulat

192 Hibernating myocardium was characterized by severe regio

193 n the fasting state, FDG uptake in pigs with hibernating myocardium was heterogeneous and was increas

194 Although, originally, hibernating myocardium was identified by a mismatch betw

195 After 3 months (n=8), hibernating myocardium was present as reflected by reduc

196 The physiological substrate of hibernating myocardium was present before SCD, with redu

197 An interaction between treatment and hibernating myocardium was present such that early revas

198 At 3 months, physiological features of hibernating myocardium were confirmed, with depressed LA

199 MCE parameters of perfusion in hibernating myocardium were similar to segments with nor

200 The improvement of wall thickening of hibernating myocardium with NTG and dobutamine, from 23.

201 We previously produced hibernating myocardium with reduced resting flow in pigs

202 ing artery (LAD) stenosis to produce chronic hibernating myocardium with regional contractile dysfunc

203 f ischemic and dysfunctional myocardium (ie, hibernating myocardium) and infarct size were each indep

204 n reversible loss of cardiomyocyte function (hibernating myocardium), which is amenable to therapeuti

205 t persistent myocardial stunning can lead to hibernating myocardium, 13 pigs were chronically instrum

206 nal myocardium with reduced resting flow, or hibernating myocardium, after 3 mo.

207 emodeling in the cardiac interstitium of the hibernating myocardium, an important predictor of recove

208 There was no lactate production in hibernating myocardium, and lactate uptake increased dur

209 identification of candidates with regions of hibernating myocardium, because these patients stand to

210 measured the expression of survival genes in hibernating myocardium, both in patients surgically trea

211 hat dobutamine echocardiography can identify hibernating myocardium, but laboratory studies suggest t

212 Hibernating myocardium, characterized by reductions in f

213 In hibernating myocardium, icMSCs increased function (perce

214 ion in coronary BF in conscious pigs induced hibernating myocardium, ie, perfusion-contraction matchi

215 Hibernating myocardium, ischemic myocardium, and scarred

216 In hibernating myocardium, MIBG deposition was decreased in

217 Using an established model of chronic hibernating myocardium, mini-swine underwent 90% proxima

218 this preclinical swine model of ischemic and hibernating myocardium, the combined delivery of circula

219 t in perfusion reserve is well recognized in hibernating myocardium, there is substantial controversy

220 tensive defects in HED uptake were found for hibernating myocardium, with regional retention approxim

221 resting myocardial blood flow is reduced in hibernating myocardium.

222 d stability of sympathetic dysinnervation in hibernating myocardium.

223 d for at least 2 mo after the development of hibernating myocardium.

224 ) to improve flow and function in swine with hibernating myocardium.

225 titative CMR perfusion imaging is reduced in hibernating myocardium.

226 beta-receptor adenylyl cyclase signaling in hibernating myocardium.

227 ion is attenuated in patients and swine with hibernating myocardium.

228 mpathetic norepinephrine uptake in pigs with hibernating myocardium.

229 survival of medically treated patients with hibernating myocardium.

230 entricular dysfunction are features of human hibernating myocardium.

231 ative to revascularisation for patients with hibernating myocardium.

232 lic adjustments could facilitate survival of hibernating myocardium.

233 r non-hibernators according to the volume of hibernating myocardium.

234 the excess mortality seen in the setting of hibernating myocardium.

235 the observed depression of function seen in hibernating myocardium.

236 l, molecular, and morphological phenotype of hibernating myocardium.

237 pinephrine uptake-1 mechanism is impaired in hibernating myocardium.

238 ta4 in a translational large animal model of hibernating myocardium.

239 he result of a mixture of scarred as well as hibernating myocardium.

240 tural adaptations was evaluated in pigs with hibernating myocardium.

241 ntadecanoic acid (IPPA), to identify viable, hibernating myocardium.

242 EGF(165) GTx may successfully rescue foci of hibernating myocardium.

243 n PET has been used successfully to diagnose hibernating myocardium.

244 cardium having the physiological features of hibernating myocardium.

245 nctional recovery after revascularization in hibernating myocardium.

246 nse to dobutamine have been used to identify hibernating myocardium.

247 ventricular arrhythmias, and reperfusion of hibernating myocardium.

248 ustained, the result is necrosis rather than hibernating myocardium.

249 gh-dose dobutamine from inducing ischemia in hibernating myocardium.

250 has been increasingly used for detection of hibernating myocardium.

251 stenosis and to 78+/-17 mL 7 days later with hibernating myocardium.

252 th through myocyte apoptosis in hypoperfused hibernating myocardium.

253 inducing deterioration of wall thickening in hibernating myocardium.

254 rapeutic efficacy in a large animal model of hibernating myocardium.

255 injected transendocardially in the areas of hibernating myocardium.

256 s using a clinically relevant swine model of hibernating myocardium.

257 ncreasing myocardial perfusion in swine with hibernating myocardium.

258 Many of these patients have "hibernating" myocardium secondary to chronic ischemia wi

259 reas of nonfunctional but viable (stunned or hibernating) myocardium can also contribute to the devel

260 he reversibility of molecular adaptations of hibernating myocytes.

261 olonged torpor and in squirrels that did not hibernate or had not been hibernating for several weeks.

262 EF might be mediated by improved function of hibernating or ischaemic myocardium, or both.

263 ntractile myocardium, which is distinct from hibernating or stunned myocardium.

264 ersibly hypocontractile myocardium as simply hibernating or stunned.

265 ars and garden dormice during the vulnerable hibernating period.

266 murs (genus Cheirogaleus), the only obligate hibernating primate.

267 factors ribosome modulation factor (RMF) and hibernating promoting factor (HPF) were shown to directl

268 arvester ants, in which only colonies with a hibernated queen produce new queens.

269 ed transmural variation in FDG uptake in the hibernating region (LAD/normal), which averaged 2.5 +/-

270 p, NTG alone improved wall thickening in the hibernating region modestly from 11.4+/-7.2% at baseline

271 in(-1)) dobutamine on wall thickening in the hibernating region.

272 zation may be an adaptive mechanism in such "hibernating" regions.

273 cterize dysfunctional myocardium as stunned, hibernating, remodeled and nonviable.

274 This study is the first of its kind in a hibernating reptile and provides key insight into this e

275 Hibernating ribosomes are formed by the activity of one

276 Notably, we show that hibernating ribosomes exclusively bind to the outer mito

277 Here we investigated eukaryotic hibernating ribosomes from the microsporidian parasite S

278 Replenishment of zinc to cells harboring hibernating ribosomes restores Mrf instability and disso

279 in situ structural analyses reveal that the hibernating ribosomes tether to fragmented mitochondria

280 proteins, we determined that BPOET activates hibernating ribosomes via 23S rRNA pseudouridine synthas

281 peratures for brief intervals throughout the hibernating season.

282 a marker of active remodeling, was higher in hibernating segments than in segments with persistent dy

283 trophic effects extend to myoblasts from non-hibernating species (including C. elegans), as documente

284 duced a torpor-like state similar to that in hibernating species and characterized by a marked fall i

285 y plays a primary adaptive role which allows hibernating species to tolerate such phenomena.

286 ate to elicit therapeutic hypothermia in non-hibernating species, including humans.

287 iod of snow cover also have implications for hibernating species.

288 Hibernating squirrels alternate between periods of torpo

289 The results show that [GABA](ecf) in non-hibernating squirrels was 73 nM and this level was decre

290 In vivo fiber photometry of SON neurons from hibernating squirrels, together with RNA sequencing and

291 the changes from a state of activity to the hibernating state are poorly understood; however, the se

292 itiation, regulation, and maintenance of the hibernating state.

293 Myocardial segments were defined as hibernating, stunned, remodeled or scarred.

294 crobiome-mediated urea nitrogen recycling in hibernating thirteen-lined ground squirrels (Ictidomys t

295 hermoregulatory differences between mice and hibernating thirteen-lined ground squirrels (Ictidomys t

296 yzes the regulation of ischemic tolerance in hibernating thirteen-lined ground squirrels (Spermophilu

297 cantly reduced as was its kinase activity in hibernating thirteen-lined ground squirrels.

298 e observation that eastern dwarf lemurs also hibernate, though in self-made underground hibernacula.

299 The tissue was shipped overnight in Hibernate transport medium.

300 Our findings that dwarf lemurs can hibernate underground in tropical forests draw unforesee