ライフサイエンスコーパス: hibernation

1 lex pathophysiology (e.g., myocyte death vs. hibernation).

2 unforeseen parallels to mammalian temperate hibernation.

3 of insulated hibernacula on the evolution of hibernation.

4 ery disease, many of whom exhibit myocardial hibernation.

5 ther seasonal adaptations, such as mammalian hibernation.

6 y through prolonged periods of immobility of hibernation.

7 ic cell death is independent of the stage of hibernation.

8 her protection was dependent on the stage of hibernation.

9 growing season and larger body masses before hibernation.

10 concentrations similar to those that induce hibernation.

11 2)S elicits physiological effects similar to hibernation.

12 reasing adipose stores prior to the onset of hibernation.

13 omote wakefulness and to induce arousal from hibernation.

14 Mammals encounter constant darkness during hibernation.

15 emission tomography correlate of myocardial hibernation.

16 ctivity and spatial navigation skills during hibernation.

17 glycogen, recapitulating the changes during hibernation.

18 s-associated cardiac dysfunction may reflect hibernation.

19 ity and the possible of such interactions in hibernation.

20 irrel, Spermophilus tridecemlineatus, during hibernation.

21 t phosphorylation plays a regulatory role in hibernation.

22 etitive ischemia reproducing the features of hibernation.

23 can recapitulate the phenotype of myocardial hibernation.

24 hose related to ischemic preconditioning and hibernation.

25 ow and oxygen limitation such as seen during hibernation.

26 res and winter lengths permitting successful hibernation.

27 elongation phase of protein synthesis during hibernation.

28 ay be useful in the assessment of myocardial hibernation.

29 ions fell slightly or remained stable during hibernation.

30 evaluate myocardial perfusion, function, and hibernation.

31 ibernation and reperfusion upon arousal from hibernation.

32 seen in clinical and experimental models of hibernation.

33 ctive adaptations may work in concert during hibernation.

34 nts, ascorbate and glutathione (GSH), during hibernation.

35 ccessfully adapted to this challenge through hibernation.

36 sociated with profound CNS depression during hibernation.

37 t play a major role in CNS depression during hibernation.

38 rom a physiological phenotype of stunning to hibernation.

39 scular tone and peripheral resistance during hibernation.

40 the differential expression of genes during hibernation.

41 ozyme 4 are up-regulated in the heart during hibernation.

42 incided with the early transition phase into hibernation.

43 the responses to NA were not altered during hibernation.

44 ith the traditional definition of myocardial hibernation.

45 nd O2 consumption compatible with myocardial hibernation.

46 ocardiography (DE) in identifying myocardial hibernation.

47 be relevant to conditions such as myocardial hibernation.

48 l may occur, is directly after emerging from hibernation.

49 essary to monitor undisturbed states such as hibernation.

50 longed water loss and deprivation throughout hibernation.

51 n of the physiological thirst circuit during hibernation.

52 could counteract this process by shortening hibernation.

53 l to promote fat accumulation and facilitate hibernation.

54 adverse effects on memories formed prior to hibernation.

55 conserved mechanism for eukaryotic ribosome hibernation.

56 undergo torpor lasting up to 63 h, that is, hibernation.

57 ssue function at low body temperature during hibernation.

58 100S particles in a process called ribosome hibernation.

59 ed significantly among the defined states of hibernation.

60 uding ischemic cardiomyopathy and myocardial hibernation (5, 6).

61 Hibernation, a natural model of tolerance to cerebral is

62 dy mass increases were often observed during hibernation--a phenomenon never observed in control anim

63 and short photoperiods and from hamsters in hibernation all showed at least 40% increases in fEPSP s

64 ity rates, specifically low mortality during hibernation, allows long-term bat population viability.

65 m in the presence of infarction, stunning or hibernation, alone or in combination.

66 Cooling and hibernation also induce a number of cold-shock proteins

67 Both hibernation, also called multiday torpor, and daily torp

68 sis of adaptive behaviors like migration and hibernation and advance our understanding of fundamental

69 ations in concentrations of ascorbate during hibernation and arousal in two species of hibernating gr

70 ange of biological processes, such as animal hibernation and cell survival, and is particularly relev

71 We demonstrate how earlier emergence from hibernation and earlier weaning of young has led to a lo

72 and skeletal muscle from individuals in late hibernation and four days post-arousal.

73 bear adaptations to the extreme condition of hibernation and have implications for our understanding

74 ium, both in patients surgically treated for hibernation and in a chronic swine model of repetitive i

75 inserted in some animals after they entered hibernation and in others while they remained euthermic.

76 munity, cell differentiation, organogenesis, hibernation and insulin-resistant obesity.

77 ore myocardium affected by hibernation or by hibernation and ischaemia had a greater increase in LVEF

78 t species, together with adaptations such as hibernation and low reproductive rate, contribute to the

79 ransplantation may have substantial zones of hibernation and may still be candidates for coronary byp

80 e the conditions for ribosome remodeling and hibernation and provide further insight into how zinc de

81 amatically (3-4-fold) in both species during hibernation and rapidly returned to prehibernation level

82 ae spores, bound by the conserved eukaryotic hibernation and recycling factor Lso2.

83 oridia, conservation of energy via ribosomal hibernation and recycling is critical.

84 ting the shift in cellular metabolism during hibernation and regulating neuroprotection in the brain.

85 ioxidant could play a protective role during hibernation and reperfusion upon arousal from hibernatio

86 Hibernation and short daily torpor are states of energy

87 s allow enough infected individuals to enter hibernation and survive until the following year, and he

88 neurochemistry of the cerebral mechanisms of hibernation and tolerance to cerebral ischemia exhibited

89 , ectotherms, endotherms (including those in hibernation), and plants in temperatures ranging from 0

90 e cycles, drive metabolic rhythms (including hibernation), and time annual reproduction.

91 gen-based matrix restored perfusion, reduced hibernation, and improved myocardial wall motion.

92 cardial viability in patients with suspected hibernation, and it can predict recovery of function sim

93 bility in patients with suspected myocardial hibernation, and it compared this index to currently est

94 ology, such as those affecting reproduction, hibernation, and metabolism, are controlled by pituitary

95 To identify myocardial ischemia, hibernation, and scar, the resting and stress (82)rubidi

96 vestigated how use of human foods influences hibernation, and subsequently cellular aging, in a large

97 Mating occurs shortly after emergence from hibernation, and the lipid cycle begins again with the c

98 the frequency of arousals from torpor during hibernation, and were emaciated after 3-4 mo.

99 During hibernation, animals cycle between torpor and arousal.

100 both constrictor and dilator actions during hibernation are described.

101 that myocardial adaptations consistent with hibernation are most pronounced in the subendocardial la

102 Although the biological roles of ribosome hibernation are not completely understood, this process

103 n, indeed finding that genes associated with hibernation are present, though most significantly, that

104 ic trait, theoretically this could mean that hibernation as an overwintering strategy was lost in all

105 90% reductions in cerebral blood flow during hibernation as well as rapid reperfusion upon periodic a

106 adaptations consistent with echolocation and hibernation, as well as altered metabolism, reproduction

107 llets, daily vertical migration and seasonal hibernation at depth.

108 evidence for an effect of climate change on hibernation behavior; yellow-bellied marmots are emergin

109 go a severe hypometabolic state analogous to hibernation borders on science fiction.

110 Our observations indicate that the hibernation bout is closely regulated and orchestrated b

111 activated during six different phases of the hibernation bout.

112 ticipating in phase-change regulation of the hibernation bout.

113 aking during the arousal phase of individual hibernation bouts.

114 d not change significantly during individual hibernation bouts.

115 The wasps exploited ornamental butterfly "hibernation boxes" in pollinator gardens as nesting habi

116 taine (422%) and choline (18%) levels during hibernation, but exhibited undetectable levels of TMAO.

117 e quantified the biochemical adaptations for hibernation by comparing the proteome, metabolome, and h

118 70S C- ribosome is exclusively targeted for hibernation by mycobacterial-specific protein Y (Mpy), w

119 , noninvasive imaging of myocardial scar and hibernation can inform the risk of sudden cardiac death.

120 te severe hypoxia or ischemia, including the hibernation-capable Arctic ground squirrel (AGS).

121 sought to determine whether CI and WI during hibernation caused caspase-3 activation, tubular apoptos

122 Hibernation causes reduced synaptic activity and experim

123 d challenged them with Pd upon transfer into hibernation chambers.

124 mained higher 3 h after induced arousal from hibernation compared with euthermic controls.

125 es seasonally, with higher expression during hibernation compared with the summer active state.

126 Hibernation consists of prolonged periods of torpor, las

127 s bats to arouse with unusual frequency from hibernation, contributing to premature depletion of fat

128 orresponding to various stages of the annual hibernation cycle.

129 tory rate of the meadow jumping mouse during hibernation cycles.

130 dial blood flow had increased (P</=0.01) and hibernation decreased (P<0.01) in the cells+matrix group

131 During myocardial hibernation, decreases in coronary perfusion elicit inhi

132 hey spend too much time out of torpor during hibernation, depleting vital fat reserves required to su

133 n sex hormone-binding globulin levels during hibernation draws, for the first time, attention to its

134 ogrammed manner by undergoing deep torpor or hibernation during which the hypothalamic setpoint for b

135 Conclusion: This "hepatic hibernation" during prolonged moderate hypoxia may repre

136 ing survival strategies-including torpor and hibernation-during which their body temperature decrease

137 days per year, over a 20-year period) in the hibernation emergence date of adult females in a wild po

138 s, suggesting that the thermal dependence of hibernation energetics constrains the biogeography of th

139 As an example, we use the well-quantified hibernation energetics of the little brown bat (Myotis l

140 lasma protein concentration increased during hibernation, even though the concentrations of most indi

141 was the identification of mRNAs for ribosome hibernation factors (the rmf and PA4463 genes) at the bo

142 We examined the effect of diet on pre-hibernation fattening and the gut microbiota of captive

143 Our results demonstrate that pre-hibernation fattening of arctic ground squirrels is robu

144 sumably are related to disrupted patterns of hibernation, food intake, and metabolism.

145 edge and suggest possible roles in mammalian hibernation for peroxisome proliferator-activated recept

146 main in a state of drought-imposed dormancy (hibernation) for many years.

147 enes associated with regulating arousal from hibernation (GABARB1), breakdown of fats (cGMP-PK1), and

148 Thus, hibernation has been retained in at least one primate ou

149 to climate change in some analyses, whereas hibernation, heterothermy, burrowing, nesting, and study

150 n, extremely high metabolic rates, nocturnal hibernation, high brain-to-body size ratio and a remarka

151 We used a combination of artificial hibernation, hormonal treatments, gene expression analys

152 The hibernation hypothesis predicts that nova eruptions stro

153 -like growth factor signaling pathway during hibernation (i.e., phosphorylated FKHR was significantly

154 Specifically, we show that ribosome hibernation in a batch culture is induced at an approxim

155 tion trigger (HIT), has been shown to induce hibernation in active animals and afford myocardial prot

156 n fact, most patients have both scarring and hibernation in different regions.

157 bolic status that occur during the course of hibernation in European hamsters cause structural change

158 cation of regulatory mechanisms that control hibernation in ground squirrels can guide efforts to dev

159 cation of regulatory mechanisms that control hibernation in ground squirrels may guide efforts to dev

160 Their relevance to myocardial hibernation in humans is unknown.

161 h intravenous contrast identifies myocardial hibernation in humans.

162 indicating that HPF is required for ribosome hibernation in L. monocytogenes.

163 Hibernation in mammals is a remarkable state of heteroth

164 Hibernation in mammals is a reversible state of suspende

165 hocardiography (MCE) in detecting myocardial hibernation in man and its comparative accuracy to dobut

166 e and underweight male hibernators terminate hibernation in spring when aboveground food becomes avai

167 ble for the physiological characteristics of hibernation in the heart of the thirteen-lined ground sq

168 CKD, across animal species as well as during hibernation in two animal species.

169 can enter a severe hypothermic state during hibernation in which metabolic activity is extremely low

170 everal genes differentially regulated during hibernation, including Pdk4 and Serpinf1.

171 Hibernation increased the proportion of myosins in the S

172 ulted from adaptive introgression related to hibernation, indeed finding that genes associated with h

173 Microbiome alterations may contribute to hibernation-induced changes in the intestinal immune sys

174 zed factor derived from hibernating animals, hibernation induction trigger (HIT), has been shown to i

175 udy undertook to test whether treatment with hibernation induction triggers could improve myocardial

176 Furthermore, hibernation-induction triggers extend organ preservation

177 other physiological variables that accompany hibernation involve only modest reprogramming of gene ex

178 Central functions in hibernation involving the coagulation response and prote

179 Hibernation is a physiological adaptation characterized

180 Hibernation is a physiological state employed by many an

181 Together, we propose that ribosome hibernation is a specific and conserved response to zinc

182 Mammalian hibernation is a temporary suspension of euthermia allow

183 The mechanisms by which hibernation is achieved in microsporidia, however, remai

184 ration or progressive fibrosis suggests that hibernation is adaptive rather than an unstable physiolo

185 Myocardial hibernation is an adaptive response to ischemia and hypo

186 Hibernation is an energy-conserving state, now known to

187 Hibernation is an extreme response to a seasonal environ

188 Myocardial hibernation is associated with an inflammatory response

189 Myocardial hibernation is associated with structural myocardial cha

190 Since hibernation is commonly viewed as an ancient, plesiomorp

191 the majority of metabolic suppression during hibernation is independent of lowered body temperature.

192 ch the C- ribosome remains active, while its hibernation is inhibited by the caseinolytic protease (C

193 Typically, hibernation is observed in cold-adapted mammals, though

194 Hibernation is one of the most dramatic examples of phen

195 ith a chronic stenosis and hypothesized that hibernation is preceded by chronic stunning with normal

196 One of the characteristics of animals in hibernation is reduced behavioral activity.

197 Hibernation is studied because it represents a unique st

198 suggested that chronic stunning rather than hibernation is the principal cause of regional wall moti

199 An integral aspect of hibernation is the profound decrease of cerebral perfusi

200 An integral aspect of hibernation is tolerance to a profound decrease of cereb

201 creased for 12 weeks in spring, from minimal hibernation levels (mean 20-25 beats/minute [bpm]; min 1

202 We suggest that a distinct post-hibernation life history stage consisting mostly of rest

203 The Caenorhabditis elegans dauer state is a hibernation-like state of diapause that displays a drama

204 ocks somatic growth and sensitizes mice to a hibernation-like state of torpor.

205 Torpor is a short-term hibernation-like state that allows conservation of metab

206 ortedly minimize energy losses by entering a hibernation-like state when deprived of food.

207 suprachiasmatic nucleus, abolishes torpor, a hibernation-like state, implicating the circadian clock

208 tics is believed to be due to persistence, a hibernation-like survival mechanism modulated, in part,

209 The hibernation mass loss phase begins after the body mass p

210 Recent work has suggested hibernation may also slow the process of senescence, or

211 Together these results suggest that although hibernation may ameliorate cellular aging, foraging on h

212 anding of how renal protection occurs during hibernation may help in understanding the pathophysiolog

213 anisms underlying neuroprotective aspects of hibernation may lead to novel therapeutic strategies for

214 However, hibernation may represent persistent myocardial stunning

215 We hypothesized that myocardial hibernation may underlie sepsis-associated myocardial de

216 sumo-2/3-ylation may also be associated with hibernation-mediated neuroprotection.

217 In myocardial hibernation, methods evaluating rest perfusion (MCE, Tl-

218 cumflex artery territory (both P<0.001), and hibernation (mismatch) was observed.

219 asticity, silent yet intact circuits enter a hibernation mode marked by reduction of presynaptic axon

220 The hibernation model predicts cyclical evolution of catacly

221 A pig model of myocardial hibernation of 24 hours to 7 days was created through se

222 pose a novel concept of inflammatory-induced hibernation of the fetus.

223 Recanalization of CTO is followed by a hibernation of vascular wall at distal coronary segments

224 We hypothesize that the slowing effects of hibernation on metabolic and viral activity maintains in

225 n the renal artery, the long term effects of hibernation on perivascular nerve activity, and the resp

226 The first report of the effect of hibernation on the gut microbiota of bears reveals trend

227 that it could play a protective role during hibernation or arousal.

228 r, patients with more myocardium affected by hibernation or by hibernation and ischaemia had a greate

229 n response to reduced hemodynamic demands of hibernation or pathogenic HCM variants.

230 To date, the underlying mechanism for hibernation or similar behaviors remains an enigma.

231 body temperatures of animals can drop during hibernation or torpor covering a large range of temperat

232 levels, with timing of animal reproduction, hibernation, or migration becoming detached from peak fo

233 eu5-enkaphalin (DADLE), which mimics natural hibernation, or preperfusion with DADLE, administered fo

234 that a good candidate species for the use of hibernation, outside of Madagascar should be the pygmy s

235 Interestingly, the subcellular changes in hibernation parallel the altered biology of induced card

236 ectrum of delayed recognition where both the hibernation period and the awakening intensity are taken

237 Its citation history exhibits a long hibernation period followed by a sudden spike of popular

238 a thousand to a million years, starting the hibernation phase.

239 Given that lipids are integral in the hibernation phenotype they may play important regulatory

240 However, several other aspects of hibernation physiology are also consistent with toleranc

241 significant but unknown role in maintaining hibernation physiology.

242 ated by ribosome modulation factor (RMF) and hibernation promoting factor (HPF), or alternatively, th

243 genes in Synechococcus, including ribosomal hibernation promoting factor (hpf), which causes ribosom

244 oteins, ribosome modulation factor (RMF) and hibernation promoting factor (HPF), while most Gram-posi

245 onstrate that the P. aeruginosa gene PA4463 [hibernation promoting factor (HPF)], but not the ribosom

246 aphylococcus aureus and most other bacteria, hibernation-promoting factor (HPF) homodimerizes the 70S

247 These proteins include hibernation-promoting factor (HPF), which dimerizes ribo

248 taphylococcus aureus, a small protein called hibernation-promoting factor (HPFSa) is sufficient to di

249 active 70S dimers (called 100S ribosomes) by hibernation-promoting factor is a widespread survival st

250 revealed unexpected homology with bacterial hibernation-promoting factors that bind to ribosomes and

251 This study demonstrates that hibernation protection with DADLE is beneficial for prol

252 ition cycles of the living material (active, hibernation, reactivation).

253 Myocardial hibernation refers to a state of persistent left ventric

254 Myocardial hibernation refers to a state of prolonged impairment of

255 ll bears, including an individual denned for hibernation, responded to UAV flights with elevated hear

256 proach, investigating expression of putative hibernation-responsive genes by Northern analysis, revea

257 Hibernation results in dramatic changes in body temperat

258 Samples were collected during the hibernation season from arctic ground squirrels (AGS; Sp

259 Furthermore, torpid squirrels during the hibernation season keep their brain temperature signific

260 In order to survive the multi-month hibernation season many species engage in hyperphagy, dr

261 n thermoregulation and metabolism during the hibernation season than at other times of year, thereby

262 CHA-induced torpor within the hibernation season was specific to A(1)AR activation; th

263 season, two of six AGSs tested early in the hibernation season, and none of the six AGSs tested duri

264 Throughout the hibernation season, bouts of deep torpor are punctuated

265 por in six of six AGSs tested during the mid-hibernation season, two of six AGSs tested early in the

266 AGS), display torpor only during the winter, hibernation season.

267 squirrel, Spermophilus lateralis, during the hibernation season.

268 As such, hibernation serves as a model for studying natural toler

269 cient lipid reserves spontaneously terminate hibernation several weeks before females and independent

270 ble on molecular changes that correlate with hibernation state, and what has been done focused mainly

271 anied by maintaining inactive ribosomes in a hibernation state, in which they are bound by proteins w

272 s the stability of mRNA as a function of the hibernation state, we examined the poly(A) tail lengths

273 ctic ground squirrels sacrificed during four hibernation states (early and late during a torpor bout

274 some small differences were observed across hibernation states, none of the 29 had significant chang

275 d both active (eating) and waiting (dormant, hibernation) states with additional recovery for reiniti

276 eveal a new role in the reversal of ribosome hibernation that is intimately linked to bacterial patho

277 nd ribosome biogenesis during both stages of hibernation that suggests induction of translation durin

278 prolonged partial occlusions (ie, short-term hibernation), the time course of functional recovery var

279 During hibernation, the 13-lined ground squirrel (GS) cycles th

280 For true hibernation, the geographical restriction was absolute.

281 In myocardial hibernation, the majority of recovery of rest function o

282 he Leydig cells in a state of steroidogenic "hibernation," the reductions in Leydig cell testosterone

283 nt as the patient's physiology moves toward "hibernation." The agents we utilize as sedative and pres

284 el was decreased by approximately 50% during hibernation thereby suggesting that an increase in [GABA

285 The seasonal character of hibernation thus provides a clue to its regulation.

286 lude suspended animation-like states such as hibernation, torpor, and estivation.

287 otential role of the CNS in the induction of hibernation/torpor, since CNS-driven changes in organ ph

288 This study reveals how hibernation triggers the production of new queens in Pog

289 level of metabolic shutdown (analogous to a hibernation-type response), seems to be crucial in deter

290 l that predicts the feasibility of mammalian hibernation under different climatic conditions.

291 sess whether the adaptations consistent with hibernation varied across the myocardial wall.

292 Our comparison of gene expression in hibernation versus muscle atrophy identified several gen

293 rels maintained in the laboratory and affect hibernation via an SCN-independent mechanism.

294 tunning (rest asynergy with normal flow) and hibernation was present in 15 of 23 (65%) patients.

295 By measuring hydration status during hibernation, we show that squirrels remain hydrated duri

296 GS kidneys at various stages of hibernation were subjected to ex vivo CI.

297 ces, were less likely to survive their first hibernation, were more likely to disperse and were less

298 e as a source of electrons during periods of hibernation when food supplies are low.

299 atty acids may be preferentially used during hibernation, whereas polyunsaturated fatty acids may be

300 ther regional LV dysfunction with myocardial hibernation without transmural or extensive infarction c