ライフサイエンスコーパス: high risk

1 h among "low risk" (1.1 = 3.4-2.3 days) and "high risk" (1.1 = 3.6-2.5) pregnanices.

2 e in preventing type 2 diabetes in people at high risk(1,2).

3 e sensitivity for identifying LS carriers in high-risk (89.3% v 85.7%; P = .712) and oncology clinic

4 in newly diagnosed paediatric patients with high-risk acute myeloid leukaemia.

5 With up to 14 years of follow-up, high-risk adenomas were associated with an increased ris

6 in genes frequently mutated in ATL than did high-risk, age-matched HTLV-1 carriers who remained ATL-

7 us etoposide for patients > 4 years old with high-risk ALL undergoing allogeneic HSCT.

8 and even in those individuals that carry the high-risk allele of rs1061170 (Y402H).

9 topic dermatitis compared to children from a high-risk allergy cohort with comparable rates of parent

10 venting thromboembolic events in patients at high risk and describes the emerging therapeutic strateg

11 ightfold difference in risk between women at high risk and those at general risk.

12 ong 308 CMV seronegative recipients, 168 CMV high-risk and 203 belatacept-treated patients were inclu

13 ulopathy in patients of African ancestry and high-risk APOL1 genotype infected with SARS-CoV-2 have e

14 eased investment in health care resources in high risk areas may have produced additional unobserved

15 ed monitoring approaches and by prioritizing high-risk areas for management.

16 s (TBE), with Stockholm County as one of the high-risk areas.

17 Defining high risk as having at least one biological parent with

18 levated anxiety symptoms in combination with high-risk biological factors such as APOEepsilon4 and su

19 or who otherwise self-identified as being at high risk but were not in serodifferent partnerships or

20 Outcomes for those identified as high risk by the model were significantly worse than for

21 Health care workers at high risk can contribute in other ways to patients and p

22 m can correctly reclassify IPNs into low- or high-risk categories in more than a third of cancers and

23 65% malignancy thresholds defining low- and high-risk categories, the overall net reclassifications

24 than 20% of the study population are in the high-risk category, of whom 13.7% were older than 70 yea

25 ars underwent follow-up within days based on high-risk characteristics, and no false-negative tears p

26 yrosine-kinase inhibitor, despite the use of high-risk chemotherapy regimens and frequent HSCT upon f

27 Thus, from an evolutionary standpoint, some high-risk childhood cancers are born bad, whereas others

28 AZM targeted to high-risk children may preserve benefit while minimizing

29 ppocampal biomarkers in subjects at clinical high risk (CHR) for psychosis to further characterize th

30 Patients at clinical high-risk (CHR) for psychosis show elevations in [(18)F]

31 nd DPFC system disturbances may lead to very high risk circumstances in which suicidal ideation is co

32 er this lineage might constitute an emerging high-risk clone.

33 P. aeruginosa sequence types (STs), termed "high-risk clones." We noted that clonal complex (CC) 446

34 Our findings show that the known high-risk CNVs are not only associated with schizophreni

35 revent serious cardiac complications in this high-risk cohort of women need to be developed.

36 actors associated with CT/NG prevalence in a high-risk cohort of Zambian female sex workers and singl

37 gression to type 1 diabetes in a prospective high-risk cohort.

38 er RDN was similar for patients with varying high-risk comorbidities and across the range of ASCVD ri

39 cular focus on what are currently considered high-risk components-namely, the production of small dro

40 ) specimens were collected from the case and high-risk contacts and tested for SARS-CoV-2.

41 t is associated with increased prevalence of high-risk coronary plaque and risk of cardiovascular eve

42 o were symptomatic, had recently traveled to high-risk countries, or had contact with infected person

43 Younger patients less frequently met very high-risk criteria for intensive secondary prevention li

44 patients, and 57% and 72% for patients with high-risk cytogenetics.

45 59 years (range, 40-76 years), and 35.5% had high-risk cytogenetics.

46 he ATRX tumor-suppressor gene correlate with high-risk disease and poor prognosis.

47 tial or reinduction chemotherapy and initial high-risk disease are risk factors in relapse.

48 ated patients with CLL, including those with high-risk disease such as del(17p) CLL.

49 Men with high-risk disease were all prescribed 24 months of andro

50 esence of low-/intermediate-risk disease and high-risk disease without the need for additional clinic

51 However, in some high-risk districts in Africa, a 95% coverage may be req

52 nd outcomes associated with HHV-6 viremia in high-risk donor CMV-seropositive and recipient CMV-seron

53 lassification has strong prognostic value in high-risk EC, with significantly improved RFS with adjuv

54 ersus radiotherapy alone (RT) for women with high-risk endometrial cancer (EC).

55 rapy Versus Radiotherapy Alone in Women With High-Risk Endometrial Cancer (PORTEC-3) trial investigat

56 nce of 13.6% and 54.5% for intermediate- and high-risk episodes, respectively.

57 of the participants (719 of 821) reported a high-risk exposure to a confirmed Covid-19 contact.

58 aring neither a face mask nor an eye shield (high-risk exposure) or while wearing a face mask but no

59 -day exclusion from work policy for HCP with high-risk exposure.

60 istrative personnel, underlying disease, and high-risk exposure.

61 al upper incisor inclination can be signs of high-risk factors.

62 ed these for specific segregation within the high-risk families, and for association of variants with

63 sychArray genotypes from suicide cases in 43 high-risk families, identifying 30 distinct shared genom

64 Optic nerve (ON) invasion is an important high-risk feature, and an indicator for neoadjuvant chem

65 essential to avoid missing such an important high-risk feature.

66 lications in PCOS should focus on women with high-risk features rather than all women with PCOS.

67 High-risk features were defined by bulky tumors, variant

68 ary angiography (CTPA) rates in subgroups at high risk for adverse imaging outcomes, including young

69 Despite having high risk for ASCVD events, patients with PAD were less

70 f inherited intellectual disabilities with a high risk for ASDs.

71 d 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophre

72 , evidence links HLA alleles associated with high risk for autoimmune disease with ICI-induced T1D an

73 NPS improves the identification of groups at high risk for breast cancer, type 2 diabetes, inflammato

74 eted fluorescent peptide, in a population at high risk for colorectal cancer.

75 N hamartoma tumor syndrome (PHTS) and are at high risk for developing breast, thyroid and other cance

76 ess in pregnant adolescents, a population at high risk for distress, in association with neonatal hip

77 upper gastrointestinal bleeding who were at high risk for further bleeding or death, endoscopy perfo

78 ing to persons living in Iceland who were at high risk for infection (mainly those who were symptomat

79 Kidney transplant recipients at high risk for infections might benefit from enhanced sur

80 one lower-extremity revascularization are at high risk for major adverse limb and cardiovascular even

81 ay aid physicians in identifying patients at high risk for Mp CAP.

82 italization for HFpEF identifies patients at high risk for near-term clinical progression.

83 i.e., <= 32 weeks gestational age) remain at high risk for neurodevelopmental impairments.

84 Moreover, PGSs stratified patients with high risk for progressive disease indicated by worse pro

85 in the management of individuals at clinical high risk for psychosis (CHR) is that it is difficult to

86 nical outcomes vary among youths at clinical high risk for psychosis (CHR-P), with approximately 20%

87 s among help-seeking individuals at clinical high risk for psychosis by identifying covariant longitu

88 r problem behavior and are at a particularly high risk for serious impairment relative to others with

89 to 10-year postpartum window associates with high risk for subsequent metastatic disease.

90 ated cardiac biomarkers in middle age are at high risk for the development of heart failure with pres

91 ow sensitivity for detecting TOC in women at high risk for TOC.

92 Patients receiving LT) for HCC are at a high risk for tumor recurrence.

93 ws metabolic deterioration in individuals at high risk for type 1 diabetes.

94 after 1 year of treatment in individuals at high risk for type 1 diabetes.

95 Remarkably high risks for second in situ squamous cell carcinoma of

96 sed model identified very preterm infants at high-risk for cognitive, language, and motor deficits at

97 ging system, but also identifies patients at high-risk for early death.

98 identified a Swedish National Sample of 666 high-risk full sibships and 2,596 high-risk half sibship

99 of the following: gene expression profiling high risk (GEP(hi)), t(14;16), t(14;20), del(17p) or amp

100 ons that are currently offered to women with high-risk germ-line mutations, the in vivo HSPC gene the

101 only effective options offered to women with high-risk germline mutations.

102 ion of high MELD patients transplanted with "high-risk" grafts.

103 C]ABP688 BP(ND) values were only seen in the high risk group that used high quantities of cannabis.

104 As a practicing frontline surgeon in a high risk group, the hospital offered the author, and ot

105 At multivariable Cox analysis, the high-risk group (TP53, RB1, and/or KDM6A mutations) was

106 ariable logistic regression, patients in the high-risk group were more likely to require renal replac

107 The model identified a high-risk group with over 30 times the occurrence rate o

108 hter's transformation occurred in 17% of the high-risk group, and in no patient in the low-risk group

109 valve intervention improves outcomes in this high-risk group.

110 ngoing PMTCT efforts, and the vaccination of high-risk groups, diagnosing and treating HBV infection

111 ple of 666 high-risk full sibships and 2,596 high-risk half sibships containing at least one home-rea

112 73.9% (66.0-82.7), respectively (low-risk vs high-risk hazard ratio [HR] 0.04, 95% CI 0.0-0.1, p<0.00

113 Among patients with high-risk heart failure, the incidence of death from car

114 To follow up on the earlier analysis on high-risk HLA-DQ2.5 and DQ8.1, the current analysis unco

115 Factors associated with high-risk HPV (HR-HPV) persistence and incidence were as

116 l samples were positive for at least 1 of 13 high-risk HPV (hrHPV) types.

117 therapy (ART) on the natural history of anal high-risk HPV and anal lesion progression is not well es

118 support the model that PTPN14 degradation by high-risk HPV E7 leads to repression of differentiation

119 ginine did not impact the ability of several high-risk HPV E7 proteins to bind and degrade the retino

120 stently reported factor associated with oral high-risk HPV persistence.

121 llected for Xpert HPV (an assay that detects high-risk HPV types in five channels: HPV type 16; HPV t

122 ubstrate proteins for low-risk HPV-11 E6 and high-risk HPV-16 E6.

123 at the degradation of PTPN14 is required for high-risk HPV18 E7 to extend keratinocyte life span.

124 0.0040) and as group categories (low-risk vs high-risk HR 0.27, 0.1-0.7, p=0.005).

125 (HR 15.39, 95% CI 2.01-118.09, p = .009) and high-risk (HR 23.81, 95% CI 3.17-178.66, p = 0.002) cate

126 The 'high risk' (HR) group includes children with one or more

127 ose larger than 2 mm in diameter were deemed high risk (hrTS) for vision loss.

128 amous cell carcinoma (HNSCC) associated with high-risk human papilloma virus (HPV) infection is a gro

129 thought to play a role in modulating risk of high-risk human papillomavirus (hrHPV) infection.

130 pathology, with an increasing occurrence of high-risk ICI-related myocarditis.

131 orts of pancreas cancer screening studies in high-risk individuals and expert opinion.

132 gest potential for genetic stratification of high-risk individuals and for genetically-informed prior

133 manifestation of the HFpEF syndrome in these high-risk individuals.

134 For the subset of high-risk infants later diagnosed with autism, infant th

135 with a significant survival advantage among high-risk infants, and this advantage is strongly influe

136 ctic treatment against RSV, palivizumab, for high-risk infants.

137 strated that, regardless of mutation status, high-risk leukemic cells could only be killed using RAS-

138 rts the notion that patients with IDH-mutant high-risk LGG regardless of codeletion status receive be

139 Two hundred twenty-four participants with high-risk LVH were identified by cardiac magnetic resona

140 g patients younger than 18 years of age with high-risk, mature B-cell non-Hodgkin's lymphoma (stage I

141 ng children and adolescents with high-grade, high-risk, mature B-cell non-Hodgkin's lymphoma and was

142 intermediate phase of disease progression in high-risk MM.

143 Key inclusion criteria were the absence of high-risk multiple myeloma and an Eastern Cooperative On

144 High-risk multiple myeloma was defined by one of the fol

145 4) translocation obtained from patients with high-risk multiple myeloma.

146 early phase clinical trials in children with high-risk MYCN-driven disease, with limited ability to e

147 inical practice change whereby patients with high-risk myocardium were identified on daily rounds.

148 Three decades ago, high-risk NB metastatic to bone and bone marrow in child

149 a component of presumptive HIV treatment in high-risk neonates.

150 ance mechanism (TMM) on clinical outcomes in high-risk neuroblastoma, we integrated the C-circle assa

151 Patients with high-risk non-muscle invasive tumors that do not respond

152 the mainstay of therapy for intermediate and high-risk non-muscle-invasive bladder cancer, the therap

153 HCP with high-risk occupational exposure to COVID-19 had increase

154 nt groups not previously recognized to be at high risk of aspergillosis.

155 Limitations include high risk of bias and moderate to very low certainty of

156 All studies were at high risk of bias for index test domain because no repor

157 This is likely due to the high risk of bias identified in the study designs and an

158 All had a high risk of bias.

159 th atrial fibrillation, including those with high risk of bleeding.

160 E, although caution is needed in patients at high risk of bleeding.

161 rtension and mean 24-hour BP associated with high risk of cardiovascular disease and progression of k

162 aboratory data could identify individuals at high risk of COVID-19 and enable prioritization of PCR t

163 Although this high risk of CVD has been known for decades, patients wi

164 tients with PH in the absence of eLAP are at high risk of death and in need of focused attention.

165 iven to delay the discharge of patients with high risk of death on ICU admission.

166 tients with rheumatoid arthritis (RA) are at high risk of developing cardiovascular disease (CVD).

167 e performance and to identify individuals at high risk of developing cognitive impairment.

168 eful instrument in identifying patients with high risk of developing postoperative complications.

169 Group performance status of 0-2, and were at high risk of disease as defined by the presence of an ad

170 discharge from hospital is associated with a high risk of early rehospitalization and death.

171 lantation is the only curative option, but a high risk of graft failure and poor immune reconstitutio

172 show that only about 24%-45% of US adults at high risk of HBV infection are protected.

173 lmonary hypertension) identified patients at high risk of HF readmission.

174 y early treatment of HIV-exposed neonates at high risk of HIV acquisition.

175 , there should be no more than one period at high risk of HIV infection during the follow-up period w

176 ukemia (CLL) patients may be at particularly high risk of infection and poor outcomes related to coro

177 idered only for patients with an anticipated high risk of leukemic relapse, because multiple studies

178 analysis identified a profile of children at high risk of liver injury (odds ratio, 1.56; 95% confide

179 e of the CM episode may identify children at high risk of long-term neurocognitive impairment.

180 ection during pregnancy is associated with a high risk of maternal mortality and pregnancy loss.

181 signs to identify children with pneumonia at high risk of mortality in the outpatient setting in heal

182 eve this exposure, and it is associated with high risk of nephrotoxicity.

183 ld potentially be used to stratify people at high risk of NKTCL for targeted prevention.

184 n of this model may identify patients with a high risk of NPV trigger before ablation.

185 information about vulnerable populations at high risk of opioid abuse and death.

186 for this permanent immunosuppression is the high risk of opportunistic, community, and hospital-acqu

187 ns in gross CO(2) emissions, with consequent high risk of overshooting global temperature targets.

188 ress syndrome development is associated with high risk of poor outcome even after adjustment for unde

189 n living with perinatal HIV infection have a high risk of post-partum viraemia.

190 salience abnormalities in people at clinical high risk of psychosis (CHR) relative to findings in pat

191 rmediate risk of recurrence, and 47% were at high risk of recurrence.

192 racranial stenosis was perceived to convey a high risk of recurrent stroke, but two previous trials (

193 sh optimal treatment duration in patients at high risk of recurrent VTE.

194 Different pediatric cancers with a high risk of relapse share a common generic pattern of e

195 Myocardial Infarction identified patients at high-risk of cardiovascular and noncardiovascular events

196 sify a group of patients with MPBC-HGT1 with high-risk of early progression.

197 uld be considered in all patients undergoing high-risk operations, regardless of their underlying dia

198 h apixaban, rivaroxaban, or LMWH to selected high-risk outpatients with cancer; rivaroxaban and edoxa

199 ate p53 functional states: gain of function, high risk p53 mutation (p53HRmut) and wildtype p53 (p53W

200 In the presence of any high-risk pathologic features (nodal or margin involveme

201 outcomes and was particularly important for high-risk patient groups and less robust regimens.

202 CN positively correlated with survival in a high-risk patient subset.

203 rategies such as preprocedural intubation in high risk patients when PPCI is the preferred strategy m

204 p and cause the drug to be less effective in high risk patients.

205 Nine hundred three high-risk patients (median Society of Thoracic Surgeons

206 Of the PCCRCs identified, 43% were in high-risk patients (those with inflammatory bowel diseas

207 illator (ICD) implantation in early selected high-risk patients after primary percutaneous coronary i

208 .5 mL) were detected in 6.8% (10/147) of the high-risk patients and 6.2% (2/33) with advanced disease

209 remains suboptimal for intermediate-risk and high-risk patients and novel therapies are needed.

210 classification enables earlier treatment for high-risk patients as well as reduction of unnecessary t

211 The low- and high-risk patients classified by DGM-CM6 (RI-DR) had sig

212 ver, indicates that low-dose CT screening of high-risk patients enables detection of lung cancer at a

213 factors allow more precise identification of high-risk patients for early intensive control of multip

214 into practice could standardize testing for high-risk patients in adult EDs during influenza seasons

215 en for oral cancer risk, and then they refer high-risk patients to specialists for biopsy-based diagn

216 trend towards a lower graft survival in CMV high-risk patients treated with belatacept and whether i

217 One quarter of high-risk patients underwent surgery at a low-quality ho

218 The median OS for high-risk patients was 78.2 months (95% CI, 62.2 to 94.2

219 HVPG is over 16 mm Hg improves detection of high-risk patients while markedly reducing the number of

220 This method reduced the "gray zone" (i.e., high-risk patients who had not died on follow-up) from 4

221 er a VTE polygenic risk score could identify high-risk patients who would derive the greatest VTE red

222 al disease; thus, they should not be used in high-risk patients with cardiovascular disease.

223 eported episodes of AF/AFL adverse events in high-risk patients with type 2 diabetes mellitus.

224 and secondary CVD preventive care than other high-risk patients, and an unmet need exists for improve

225 ng-term freedom from AF recurrences in these high-risk patients.

226 tablish the best treatment options for these high-risk patients.

227 mission affects the overall outcome of these high-risk patients.

228 se the risk of major adverse events in these high-risk patients.

229 stratification for the formation of BTAs in high-risk patients.

230 urgical mitral valve replacement in selected high-risk patients.

231 "High-risk" patients were best defined as those with a lo

232 nd RP in patients with clinically localized, high-risk PC at this time.

233 ique used to reinforce the identification of high-risk PC patients and lead to more precise diagnosis

234 Men with clinically localized, high-risk PC were assigned to RP alone or neoadjuvant CH

235 al staging of biopsy-proven intermediate- or high-risk PC, and 57 patients (mean age, 70.5 y old) who

236 Conclusion: In this high-risk PCa cohort, we identified advanced disease in

237 hods: Sixteen patients with intermediate- or high-risk PCa underwent (18)F-PSMA-1007 and (68)Ga-PSMA-

238 For detection of high-risk PDR, sensitivity and specificity were higher w

239 ent and Gene x Sex effects of ADCYAP1R1 in a high-risk pediatric population.

240 ent topoisomerase I inhibitors used to treat high-risk pediatric solid tumors, but they often show po

241 Pregnancy is a high-risk period for HIV acquisition in African women, a

242 rst trimester of pregnancy is a particularly high-risk period for P. falciparum infection during preg

243 Pregnancy and postpartum are high-risk periods for different forms of thrombotic micr

244 udies are needed on the effects of screening high-risk persons and to identify quality measures for d

245 ) are being used to rule out infection among high-risk persons, such as exposed inpatients and health

246 e used in a pipeline to automatically detect high-risk phenotypes of LVH in participants undergoing C

247 eter aortic valve replacement (TAVR) in this high-risk population is debated.

248 In a high-risk population of older patients with cardiovascul

249 ate MRI should be considered for patients in high-risk populations prior to EBRT because upstaging fr

250 e survival of the low-risk, medium-risk, and high-risk populations were 98.1% (95% CI 96.3-99.9), 88.

251 ing and discuss the clinical developments in high-risk populations worldwide; additionally, we addres

252 reexposure prophylaxis (PrEP) regimens among high-risk populations, including men who have sex with m

253 als of otoprotective agents are warranted in high-risk populations.

254 s that RDN is effective and durable in these high-risk populations.

255 d the pathogenesis of respiratory viruses in high-risk populations.

256 nt COVID-19 morbidity and mortality in these high-risk populations.

257 creased cardiovascular events, especially in high-risk populations.

258 pregnancies and excluded studies confined to high risk pregnancies.

259 onate) in the offspring of women attending a high-risk pregnancy clinic during the recent ZIKV outbre

260 identify sociodemographic risk factors in a high-risk pregnancy cohort (n = 122) in Chapel Hill, Nor

261 and especially practices and prescribers in high-risk prescribing was observed.

262 mplex karyotype, few co-occurring mutations, high-risk presentation and poor outcomes were specific t

263 EBRT plus ADT in men with intermediate- and high-risk prostate cancer.

264 r oral health elevated the risk of ESCC in a high-risk region of China.

265 ful for both Blacks and Whites residing in a high-risk region of the United States.

266 especially as portable inhalation devices in high-risk, resource-poor settings.

267 our strata of negligible, low, moderate, and high risk, respectively.

268 ently solid malignancies and more frequently high-risk SAB.

269 antimicrobial therapy must seek treatment in high-risk settings.

270 he pathogenic effects of membership in these high-risk sibships was substantially attenuated by high

271 and prevention (an optional track to prevent high-risk stage B pre-HF from progressing to stage C).

272 , minimally medicated patients with clinical high-risk states for psychosis; patients with recent-ons

273 c treatment of sites with active bleeding or high-risk stigmata for rebleeding.

274 Patients had localized high-risk STS (grade 3; size, >= 5 cm) of an extremity o

275 3]) and DFS in the clinical high and genomic high-risk subgroup (86.1% v 88.1%; HR, 0.83 [95% CI, 0.5

276 ve was to use (18)F-FDG PET/CT to identify a high-risk subgroup requiring therapeutic intensification

277 The NCB was particularly favorable in high-risk subgroups and those with multiple risk charact

278 22, P = 0.381 respectively), nor in specific high-risk subgroups or breast cancer subtypes.

279 We estimate the proportion of high-risk subjects in the host population by fitting com

280 e among cisgender male sex workers (MSWs), a high-risk subset of cisgender men who have sex with men

281 ES) to correct for intravascular deficits in high-risk surgical patients is either effective or safe.

282 payments and clinical outcomes of referring high-risk surgical patients to local high-quality hospit

283 ssess its clinical utility in characterizing high-risk survivors and guiding intervention strategies.

284 Among high-risk survivors, adherence to COG breast, colorectal

285 d phase II trial in patients with resectable high-risk T3, T4, and/or N2 CC on baseline computed tomo

286 ss them, and tighter genetic correlations in high-risk than in low-risk treatments.

287 sample and carry a higher mutational load in high-risk than in low-risk tumors.

288 e author, and other health care providers at high risk, the option to opt out of the care Covid-19 su

289 r schools, the proportion of schools below a high-risk threshold for vaccination coverage, and five-y

290 suggesting that young children are still at high risk to the newly emerged A(H3N2)v viruses.

291 atelet therapy (DAPT) reduced stroke risk in high-risk transient ischemic attack (TIA) patients asses

292 disrupted by SVs in 14% of MYCN nonamplified high-risk tumors based on WGS and 10% in the SNP array c

293 , CFI, and C3 genes because they harbor rare high-risk variants.

294 antiviral and steroid prophylaxis for MK in high-risk, vascularized herpetic corneal scars achieves

295 appear to be amplified when initiated in the high-risk window after hospitalization and warrant prosp

296 reduced rate of breast cancer development in high-risk women in the initial 5 years of follow-up afte

297 High-risk women were more likely to be diagnosed with st

298 wn risk factors, hampering identification of high-risk women.

299 integration of health and social services in high-risk young adults to improve TB control efforts.

300 ced substantial decline-frequently into the "high risk" zone-throughout their shifts compared to day