ライフサイエンスコーパス: high-affinity

1 anges in opioid receptor (OR) occupancy over high affinity.

2 to-late first-row transition-metal ions with high affinity.

3 ing to recombinant FAP-expressing cells with high affinity.

4 ghly cooperative receptors that still retain high affinity.

5 se nanobodies all bind specifically and with high affinity.

6 at is required for channel inactivation with high affinity.

7 to recognize these modified substrates with high affinity.

8 atterin-like domains and binds to Pfs47 with high affinity (17 to 32 nM).

9 show this preference derives from p44/p62's high affinity (20 nM) for damaged ssDNA.

10 Using a specific and high-affinity actin-binding tool compound, swinholide A,

11 at are activated by oxysterols and synthetic high-affinity agonists.

12 ully targeted and imaged using AuNS with the high-affinity amino acid sequence arginine-glycine-aspar

13 Some of these systems are capable of high affinities and selectivities, raising the hope of b

14 uble ionic calcium and crystalline HAP, with high affinity and chemical specificity.

15 cient identification of an aptamer with both high affinity and high specificity.

16 rcolin with recombinant gp120 and gp140 with high affinity and inhibition of HIV infection at nanomol

17 e core of the protein, where heme binds with high affinity and is degraded to biliverdin.

18 nzoimidazole), which binds Red Broccoli with high affinity and makes Red Broccoli resistant to therma

19 le-stranded DNA aptamer is used to bind with high affinity and selectivity alpha-syn, which is a majo

20 lpiperidin-4-yl)methanamine derivatives with high affinity and selectivity for serotonin 5-HT(1A) rec

21 e high surface-to-volume ratio of SiNWs, the high affinity and selectivity of the uranyl-binding apta

22 G, so called REX and ARS ligands with proved high affinity and selectivity to the human interleukin-2

23 t recognize and bind target molecules with a high affinity and selectivity.

24 We found that mAb-EspB-B7 has high affinity and specificity toward recombinant and nat

25 known to bind to the RNA sequence GCAUG with high affinity and specificity, but just half of Rbfox bi

26 mer peptide, (EP9) that binds to EpiSCs with high affinity and specificity.

27 hat simultaneously binds three proteins with high affinity and specificity.

28 It has high affinity and stability and is suitable for preclini

29 antagonists and inverse agonists displaying high affinity and subtype selectivity over the antitarge

30 In the design of high-affinity and enzyme isoform-selective inhibitors, w

31 This approach led to the discovery of high-affinity and high-selectivity compounds for the ant

32 udies reveal the molecular determinants of a high-affinity and high-selectivity ligand-receptor inter

33 Here, we provide a new high-affinity and selective agonist deschloroclozapine (

34 tic glycocalyx editing strategy to introduce high-affinity and specific CD22 ligands onto NK-92MI and

35 HpBARI_Hom2 also binds human ST2 with high affinity, and effectively blocks human PBMC respons

36 stem cells, bind to R-spondins (RSPOs) with high affinity, and potentiate Wnt-beta-catenin signaling

37 show that ERFE binds BMP6 directly and with high affinity, and that antibodies targeting the N-termi

38 le the rapid isolation and identification of high affinity antibodies from immunised rats.

39 The human body generates a diverse set of high affinity antibodies, the soluble form of B cell rec

40 e-molecule sensitivity, and they require two high-affinity antibodies as well as stringent washing to

41 this problem, we have generated recombinant high-affinity antibodies for a collection of thirteen cy

42 oped, which was key to the identification of high-affinity antibodies with the desired inhibitory pot

43 llicular helper T (T(FH)) cells that mediate high-affinity antibody production in tandem with the ind

44 ed for multiple enrichment rounds to harvest high-affinity aptamers as in conventional SELEX.

45 t all these analogues and identified two new high-affinity aptamers that solely bind to adenosine.

46 ore, inverse agonists binding this site with high affinity are actively being pursued.

47 The protein binds lanthanide ions with very high affinity as demonstrated by tryptophan-enhanced ter

48 to phosphorylated Annexin A2 (pANXA2), with high affinity at high levels of calcium.

49 lar to wild type (WT), and good responses to high-affinity ATP analogues, suggesting intact ion perme

50 The mutant retains high-affinity ATP binding, but was defective in producin

51 oses: 1) to effectively expand both low- and high-affinity B cells specific for the antigenic bait du

52 responses, with preferential recruitment of high-affinity B cells.

53 atter do so more efficiently after acquiring high-affinity BCRs.

54 o inflamed coronary arteries is initiated by high affinity beta2-integrin (CD11c/CD18) that activates

55 Given the nanomolar high affinity between ACE2 and SARS-CoV-2 spike protein,

56 partite binding interface required to form a high-affinity Bim1-Cik1-Kar3 complex.

57 ide interactions are often conducted only on high affinity binders due to conservative data threshold

58 ultivalency-enhanced interactions and create high affinity binding agents.

59 Although high affinity binding between streptavidin and biotin is

60 ged E3 for the proteasome, with a dedicated, high affinity binding site contributed by hRpn10.

61 site-specific glycosylation requirements for high affinity binding to these lectins.

62 By unveiling this high-affinity binding mode, our studies establish a high

63 e PPARgamma agonists with, however, a unique high-affinity binding mode.

64 Our results support the relevance of high-affinity binding of ARF transcription factors to un

65 , and MD-predicted structures shows that the high-affinity binding of Car9 to the silanol-rich surfac

66 reates a strong thermodynamic driver for the high-affinity binding of guests in aqueous solution for

67 High-affinity binding of heparin/heparan sulfate to the

68 ne through accommodation surfaces may assist high-affinity binding of HIV-1 MPER epitope at membrane

69 High-affinity binding of InsP(8) to the XPR1 N-terminus

70 s in increased resistance, probably owing to high-affinity binding of SAP2 to pyrethroid insecticides

71 nds of interactions account for the specific high-affinity binding of the c-di-AMP ligand.

72 late strand alignment in the active site for high-affinity binding of the initiating nucleotides.

73 y relying on a polyzwitterion polymer, where high-affinity binding onto the QDs is driven by multicoo

74 Our results reveal that high-affinity binding requires a distinct sequence and s

75 easing the fraction of channels presenting a high-affinity binding site for PF-05089771 and suggestin

76 of HK domain 5 (HKD5) to gC1qR shows only 1 high-affinity binding site per trimer.

77 Combining multiple high-affinity binding sites with the twofold change in F

78 ow for promiscuity in a protein selected for high-affinity binding to a single target remain unclear.

79 conformational changes in PCSK9 required for high-affinity binding to LDL particles.

80 mal titration calorimetry analysis confirmed high-affinity binding to STAT3, with K(D) of 880 nM (7g)

81 to the cell surface, and further facilitate high-affinity binding to virus-specific cell-surface rec

82 synthetic auxin derivative 5-Ad-IAA and its high-affinity-binding partner OsTIR1F74A.

83 s electrochemical detection by fabricating a high-affinity bispecific AEC (bsAEC) using two Catcher/T

84 many biological processes because it builds high-affinity bonds by using several weak binding intera

85 he inactivated state of Nav1.7 channels with high affinity but binds only weakly to channels in the r

86 cation initiator protein DnaA binds ATP with high affinity but the amount of ATP required to initiate

87 and RCK1 Ca(2+) sites, suggesting that both high-affinity Ca(2+) sites transduce their effect, at le

88 Doc2a and Doc2b are high-affinity calcium-binding proteins that interact wit

89 of inosine without cleavage and thus enable high affinity capture of inosine in RNA.

90 Converting this motif to high affinity caused ectopic enhancer activity and elimi

91 Membrane upregulation of high affinity CD11c correlated with concomitant activati

92 riven by multiple Ags, we coencapsulated the high-affinity CD4(+) mimotope (BDC2.5(mim)) of islet aut

93 tallography of the A(2A) AR with a low and a high affinity chromone derivative confirmed the predicte

94 xoY can directly bundle actin filaments with high affinity, comparable with eukaryotic F-actin-bundli

95 Da), which produces bright luminescence upon high-affinity complementation with LgBiT, an 18-kDa subu

96 nalized layer in the DGT unit exhibited both high affinity (complexation constant K(c) = 10(19.8) at

97 olo form with the cofactor bound, UvrC forms high affinity complexes with duplexed DNA substrates; th

98 gnals that convert integrin alphaLbeta2 to a high-affinity conformation, which interacts with ICAM-1

99 ency and safety of gapmer ASOs modified with high-affinity constrained Ethyl (cEt) nucleotides in the

100 menin provides a structural basis for their high-affinity, covalent interactions.

101 closely coregulated with the Anr-controlled high-affinity cytochrome c oxidase genes.

102 In the absence of high-affinity cytochrome c oxidases, deletion of mhr no

103 ction between ACE2 and S and for engineering high-affinity decoy receptors.

104 In contrast, for high-affinity decoys, noise levels first increase with i

105 This high affinity DNA binding contrasts reports made for iso

106 their application in PCR-based diagnostics, high-affinity DNA aptamer generation, site-specific labe

107 e C-terminal region of FOXN1 is required for high-affinity DNA binding and that FOXN1 has a significa

108 Zinc, which does not promote high-affinity DNA binding, is unable to induce the same

109 2A domain provides selective recognition and high-affinity docking of large dense core secretory vesi

110 A decade ago, many high-affinity drugs were thought to bind to their target

111 ADAR RNA editing enzymes are high-affinity dsRNA-binding proteins that deaminate aden

112 sms to target their bacterial hosts, such as high-affinity, environmentally hardy receptor-binding pr

113 SK channels are able to bind inhibitors with high affinity, exceptional selectivity and very slow com

114 A high-affinity Fab was selected from one of the libraries

115 ntibodies at the well surface, each having a high affinity for a specific peptide target.

116 These electrostatic hydrogels have a high affinity for a wide range of organic solutes, achie

117 Lipophilic drugs, such as taxanes, have a high affinity for adipose tissue and a resulting higher

118 CxD7L1 exhibits high affinity for ADP and ATP, a binding capacity not re

119 4694) is an amyloid-beta imaging ligand with high affinity for amyloid-beta plaques.

120 -terminal fragment ELA23-32, which possesses high affinity for APJ (K(i) 4.6 nM) and produces cardior

121 A pseudopeptide analogue with high affinity for both HLA-B*08 and the ERAP1 active sit

122 Results: (64)Cu-CuCB-bicyclam has a high affinity for both the human and the murine variants

123 tidine is a potent analgetic agent with very high affinity for brain nicotinic acetylcholine receptor

124 age through a tunnel-like structure that has high affinity for DSB.

125 Dendritic galactose moieties have a high affinity for galectin-expressing tumor cells.

126 s with eight anions in acetonitrile revealed high affinity for H(2)AsO(4)(-) (log beta(2) = 10.4(-0.4

127 cell cycle promoting genes by virtue of its high affinity for monomethylated H3K4.

128 spectrometry, we discovered variants with a high affinity for pre-microRNA hairpins.

129 (177)Lu-PSMA-617 is a radioligand with high affinity for prostate-specific membrane antigen (PS

130 and there was selection against B cells with high affinity for self-antigen.

131 Retinol, which has a high affinity for the BLG hydrophobic cavity, significan

132 These new compounds are endowed with high affinity for the CB2R and moderate to good selectiv

133 Results: Exendin-4-IRDye700DX has a high affinity for the GLP-1R, with a half-maximal inhibi

134 ntified a 7-hydroxycoumarin fluorophore with high affinity for the MIF tautomerase active site (K(i)

135 ch B cells evolve to produce antibodies with high affinity for various antigens, usually form transie

136 ry B cells (MBCs) are long-lived and produce high-affinity, generally, class-switched antibodies.

137 echanisms that govern the differentiation of high-affinity germinal center (GC) B cells into memory B

138 family 2 member 3 (SLC2A3) which encodes the high-affinity glucose transporter 3 (GLUT3).

139 ryl fluoride motif on YJH08 is essential for high-affinity GR binding in vitro, high tissue uptake in

140 High-affinity guests have been reported for the macrocyc

141 ective of the study was to determine whether high affinity haemoglobin (HAH) affects maximal and subm

142 High affinity haemoglobin and compensatory polycythaemia

143 We studied humans with high affinity haemoglobin and compensatory polycythaemia

144 Those with high affinity haemoglobin had no worsening of pulmonary

145 The high affinity haemoglobin participants demonstrated an a

146 etical models suggest there is no benefit of high affinity haemoglobin to preserve maximal oxygen upt

147 e evolutionarily adapted to hypoxia and have high affinity haemoglobin.

148 has experimentally investigated how low- and high-affinity HBOCs would perform in normoxic and hypoxi

149 ell homeostasis through its recruitment to a high-affinity heterotrimeric receptor complex (IL-2Ralph

150 emendous potential to find clinically useful high-affinity hits for the rapid discovery of drugs for

151 h NMDA acts as a competitive antagonist, and high affinity homomeric glycine activated glutamate rece

152 ion states of the low-affinity ancestral and high-affinity human NCBD/CID interactions.

153 nd to the respective H(2)Rs with moderate to high affinity (human/guinea pig/mouse K(d): 24/28/94 nM)

154 chain of FcepsilonRI, the mast cell/basophil high affinity IgE receptor.

155 allergic reaction caused by cross-linking of high-affinity IgE antibodies on the surface of mast cell

156 er T(fh)13 cells regulates the production of high-affinity IgE in mouse models of allergy and can als

157 tanding the cellular mechanisms that lead to high-affinity IgE production is required to develop bett

158 TK) is an enzyme thought to be essential for high-affinity IgE receptor (FcepsilonRI) signaling in hu

159 allergen-specific IgE, which sensitizes the high-affinity IgE receptor FcepsilonRI on mast cells and

160 IgG autoantibodies against the high-affinity IgE receptor, FceRIalpha, contribute the p

161 Most high-affinity IGFBPs were unchanged in individuals with

162 Here we show that IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregu

163 ferentiation of macrophages that express the high-affinity immunoglobulin E receptor FcepsilonRIalpha

164 n binds to PCDH15 and CDH23 with moderate-to-high affinities in vitro.

165 rdered proteins can form complexes with very high affinity in which both binding partners fully retai

166 Structures of TASK-1 bound to two high-affinity inhibitors show that both compounds bind b

167 y taking advantage of the well-described and high-affinity interaction between KRAS and CRAF, and we

168 (apt) undergoes upon binding hypoxanthine, a high-affinity interaction leading to conformational refo

169 stimulated by the UBL domain, which mediates high-affinity interaction with the polyubiquitin chain.

170 loop were also observed to be important for high-affinity interactions.

171 Ixekizumab, a high-affinity interleukin-17A (IL-17A) monoclonal antibo

172 ndrial iron homeostasis and are required for high-affinity iron import during active proliferation of

173 High-affinity islet autoantibodies predict type 1 diabet

174 [(3)H]6 reversibly labeled the receptor with high affinity (K(D) 2.08 nM).

175 ound that RPA binds RNA with an unexpectedly high affinity (K(D) ~ 100 pm).

176 uggests that the binding dynamics of low and high affinity KRAS interactors contribute to rewiring.

177 nimal size (ca. 15-20 amino acids) affording high-affinity lanthanide ion binding, and X-ray fluoresc

178 FGF18, a high affinity ligand for FGFR3, is the only FGF-based dr

179 S analysis revealed that the presence of the high affinity ligand GM1 (at substoichiometric amounts r

180 atibility 2, Q region locus 10 (H2-Q10) is a high-affinity ligand for CD8alphaalpha which also binds

181 A high-affinity ligand specific for mHTT aggregates could

182 developed a method to quantitatively select high affinity ligands and applied the Stabilized Peptide

183 s suggested that, when present together with high affinity ligands, low affinity GSL ligands can cont

184 tners, and in experiments comparing low- and high-affinity ligands and oncogenic EGFR mutants.

185 cted to help considerably the development of high-affinity ligands for TSPO-based therapies or diagno

186 However, identification of high-affinity ligands to serve as PROTAC starting points

187 ilicity of VSDs by dynamic encapsulation and high-affinity ligands to target the construct to specifi

188 d to identify hL-FABP ligands, and all eight high-affinity ligands were selectively captured from 74

189 a route to simultaneously bias pools toward high-affinity ligands while reducing the demand for targ

190 y occupied throughout this range, indicating high affinities (likely submillimolar), while only the c

191 lamino-dihydrocodeinone (CACO), that display high affinity, long residence time and pronounced select

192 The selected aptamers bind with high affinity (low nanomolar K(d) values) and selectivit

193 ether, these data reveal that Sox2 employs a high-affinity/low-specificity paradigm for RNA binding i

194 onal antibody (mAb) epitopes while retaining high-affinity mAb epitopes.

195 minority variants sustaining propagation of high-affinity majority phenotypes.

196 [n,n]CPPs showed a remarkable performance as high affinity material for vapor analyte sensing.

197 Surprisingly, we discovered that high-affinity membrane-targeted RAS binding proteins inh

198 Thus, we provide a high-affinity MIF binder as a novel tool to advance MIF-

199 t is increased through overexpression of the high-affinity mitochondrial iron importer Mrs3.

200 We found that solution contamination with a high-affinity modulator such as zinc is most likely to a

201 on in future studies aimed at characterizing high-affinity modulators of the glycine receptor.

202 tform for discovery of clinically applicable high affinity monoclonal antibodies against a broad rang

203 these binding partners is achieved through a high-affinity motif and a low-affinity motif within myos

204 SARS-CoV-2 spike (S) glycoprotein exhibits a high-affinity motif for binding TCRs, and may form a ter

205 related compounds are potent ligands for the high-affinity nicotine receptors of the brain, which are

206 elopment and drives tumorigenesis, whereas a high-affinity non-acetylatable mutant does not.

207 The genome contains several high-affinity non-functional binding sites for transcrip

208 ) transport is due to ClO(4)(-) binding to a high-affinity non-transport allosteric site that prevent

209 the C(3)-substituted indoles are selective, high affinity NOP ligands, the steric, polar, and cation

210 This restoration is not dependent on the high-affinity Nramp family Mn transporter, MumT, as a De

211 These findings suggest that high affinity of a Cas9 nuclease for its cognate PAM pro

212 lar recognition capacity of aptamers and the high affinity of aptamers with analyte to trigger TiO(2)

213 aps reflecting the specificity and generally high affinity of biologic agents, these therapeutics hav

214 In fact, molecular docking predicted a high affinity of CGA for alpha-glucosidase.

215 Given the high affinity of DupA to PR-ubiquitinated substrates, we

216 Integrative studies reveal an exceptionally high affinity of the EhActn2 CaMD for Ca(2+), binding of

217 eement with an experimental study, we find a high affinity of the hexapeptide to the binding interfac

218 topes, peripheral splenic T cells maintained high affinity only to the HIP2.5 epitope.

219 The ideal operating ranges for high-affinity P(i) adsorption using PBP resin were pH 4.

220 PBAR-G(s) complexes stabilized by either the high-affinity P395(4) or the semisynthesized bile acid d

221 Many high-affinity peptide antagonists of MDM2 and MDMX have

222 e used to exchange placeholder peptides with high affinity peptides of interest.

223 er intravenous injection of a (64)Cu-labeled high-affinity peptidomimetic ligand referred to as (64)C

224 reported to be a Y(4)R partial agonist with high affinity (pK(i) Y(4)R: 8.43).

225 phage display panning strategy to isolate a high affinity pool (KD range: 0.399-233 nM) of CD160 tar

226 Exposure to troglitazone, a high-affinity PPARgamma agonist-induced vasorelaxation i

227 Of particular concern was the high-affinity R-state PolyhHb, which led to no improveme

228 Therapeutic TCRs exhibited high affinities, ranging from nanomolar to low micromola

229 chondroitin-4-sulfate molecule for specific, high affinity receptor binding.

230 IL-2Ralpha, in part, comprises the high affinity receptor for IL-2, a cytokine important in

231 urotrophic factor (BDNF) signals through its high affinity receptor Tropomyosin receptor kinase-B (Tr

232 Both express robustly the high-affinity receptor for IgE, FcepsilonRI, and thereby

233 Tropomycin receptor kinase A (TrkA) is the high-affinity receptor for nerve growth factor.

234 BDNF and its high-affinity receptor TrkB are reduced in Alzheimer's d

235 5-LO metabolite leukotriene (LT)B(4) and its high-affinity receptor, BLT1, in this response.

236 lthy tissues bound to resident cells via its high-affinity receptor, FcepsilonRI.

237 In vivo-specific deletion of the Sema3E high-affinity receptor, plexinD1, on macrophages led to

238 ful case of ACT included oligoclonal TCRs of high affinity recognizing distinct conformations of neoa

239 dopamine receptors, D1 and D2, with low and high affinity, respectively.

240 Our structure reveals a high-affinity resting-state-specific toxin-channel inter

241 ted that chelating endolysosome calcium with high-affinity rhodamine-dextran or chelating cytosolic c

242 duced-fit conformational changes and confers high-affinity RNA hairpin binding, which may be advantag

243 rkably, SERT inhibitor Lu AF60097, the first high-affinity S2-ligand reported and characterized here,

244 Consequently, low amounts of high-affinity self-reactive T cells also escaped the thy

245 nism that will facilitate rational design of high-affinity SERT allosteric inhibitors.

246 inst RBD, leading to the identification of a high-affinity single-chain fragment variable region (scF

247 Intracellular delivery of high-affinity, single-domain antibodies may offer a new

248 iology would result from their conversion to high-affinity sites (thereby mimicking FadR overproducti

249 specific sites into high-affinity sites, and high-affinity sites into 'super sites' that exhibit stro

250 tches also converted non-specific sites into high-affinity sites, and high-affinity sites into 'super

251 Unlike the other high-affinity sites, which bind NC with exothermic energ

252 9m)Tc-labeled derivative of acetazolamide, a high-affinity small organic ligand of carbonic anhydrase

253 TXB2 VNAR was identified as a high affinity, species cross-reactive VNAR antibody agai

254 In conclusion, TXB2 is a high affinity, species cross-reactive, and brain-selecti

255 their encoding messenger RNAs (mRNAs) via a high-affinity stem-loop RNA binding domain interaction,

256 We propose that high-affinity substrate binding increases the specificit

257 ng acute immune responses, T cells harboring high-affinity T cell antigen receptors (TCRs) are prefer

258 toires, we found that the immunodominance of high-affinity T cell clones declined during the chronic

259 minimal-length aptamer sequence required for high-affinity target binding.

260 ng alpha4beta2 nicotinic receptors (nAChRs), high-affinity targets for beta amyloid (Abeta).

261 ng beta2-beta3 loop sequences present in two high-affinity TBPs (K(D) values of 4.2 +/- 0.3 and 3.0 +

262 tiviral activity through its ability to form high-affinity ternary complexes containing CEP250 and FK

263 gG4 Fab-arm-exchanged autoantibodies reach a high-affinity threshold required for pathogenic capacity

264 binds an alpha-helical epitope in N-CSP with high affinity through extensive shape and charge complem

265 acts directly with one of these lncRNAs with high affinity through its HMG DNA-binding domain in vitr

266 hat the RGG motif of human FMRP binds with a high affinity to an RNAG-quadruplex structure that lacks

267 ical for the rapid expansion of B cells with high affinity to antigen.

268 ulti-walled carbon nanotubes laccase shows a high affinity to be adsorbed onto the surface of naphthy

269 Here, we report that AcrIIA1 binds with high affinity to Cas9 via the catalytic HNH domain.

270 fueled a model in which ARF dimers bind with high affinity to distinctly spaced repeats of canonical

271 acids (PNAs) are DNA analogs that bind with high affinity to DNA and RNA in a sequence-specific mann

272 ific secondary structural elements conveying high affinity to DUX4 as assessed by fluorescence resona

273 HAI-1, and recombinant HAI-2 proteins had a high affinity to form a complex with TMPRSS2.

274 All of our immunotoxins displayed high affinity to human GPC3, with HN3-T20 having a K(D)

275 the investigated metallohelices bind with a high affinity to human telomeric RNA G-quadruplex and th

276 y their superior light-harvesting system and high affinity to iron.

277 ineer an anti-VISTA antibody that binds with high affinity to mouse, human, and cynomolgus monkey VIS

278 omponents of adaptive immunity, binding with high affinity to pathogenic epitopes.

279 rs PKIalpha, PKIbeta, and PKIgamma bind with high affinity to PKA and block its kinase activity, modu

280 Annexin A5 (AnxA5) binds with high affinity to PS externalized by apoptotic cells, the

281 Intriguingly, LOTUS domains exhibit high affinity to RNA G-quadruplex tertiary structures im

282 gonucleotide was described that demonstrates high affinity to RNA, exceptional nuclease resistance, e

283 ro binding assay that identify epitopes with high affinity to soluble HLA-DRB1 molecules; and (iii) a

284 space and identify molecules that bind with high affinity to target proteins.

285 pine, a Cav1.2 Ca(2+) channel inhibitor with high affinity to the CNS.

286 ydrolysis, we demonstrate that EBs bind with high affinity to the GTP conformation of microtubules.

287 0 and 2G10, were bound specifically and with high affinity to the ketoreductase domain of DEBS module

288 small molecule, (+)SW033291, that binds with high affinity to the PGE2-degrading enzyme 15-hydroxypro

289 nsition of the transport mode of YfkE from a high-affinity to a low-affinity state.

290 se binding on the AuNP-MIP sensor revealed a high affinity toward glucose with a dissociation constan

291 nsion (Nterm) previously shown to facilitate high-affinity tRNA binding and aminoacylation.

292 cytotoxic (monomethyl auristatin E: MMAE; a high-affinity tubulin ligand).

293 from the environment, bacteria have evolved high-affinity uptake systems, predominant among which is

294 show that high-affinity vaccines targeting rare B cells capable of

295 blocks interaction between ACE2 and several high affinity variant forms of the spike protein.

296 pro-myostatin in complex with 29H4-16 Fab, a high-affinity variant of SRK-015, at 2.79 angstrom resol

297 brane protein that transports allantoin with high affinity when expressed in yeast.

298 These variants bound with high affinity with the effector-binding site of Ras in a

299 offer insights into the design of monomeric, high-affinity Xe sensors.

300 In whole-cell recordings, application of a high-affinity Y(1)R agonist led to hyperpolarization in