ライフサイエンスコーパス: high-affinity binding

1 stant (Kd) equal to about 1 nM, indicating a high affinity binding.

2 tensions flanking the central PXXP motif for high affinity binding.

3 pR thereby contributing significantly to its high affinity binding.

4 CCL7 renders oligomerization unnecessary for high affinity binding.

5 ndertaken to elucidate the basis of the very high affinity binding.

6 vers oligomer expansion as a requirement for high affinity binding.

7 contacts but is substantially attenuated in high affinity binding.

8 ommon SUMO1-specific interactions needed for high affinity binding.

9 tion of basic charge on MAM7 is required for high affinity binding.

10 ggesting that multiple solutions may support high-affinity binding.

11 d favorable interactions contributing to the high-affinity binding.

12 residues, Lys21 and Tyr22, are essential for high-affinity binding.

13 iboswitch, divalent cations are required for high-affinity binding.

14 ional amino acids are critically involved in high-affinity binding.

15 ally grafted polar residues are critical for high-affinity binding.

16 ptimizes the surrounding contact surface for high-affinity binding.

17 e opposing minor groove and are required for high-affinity binding.

18 hese peptides are essential for the observed high-affinity binding.

19 four nucleotides adjacent to the 5' cap for high-affinity binding.

20 and requires the K-Ras polybasic region for high-affinity binding.

21 agonist (+)-pentazocine did not compete for high-affinity binding.

22 city in the interface composition supporting high-affinity binding.

23 where high GTP levels are present; however, high affinity binding [(3)H]PGE(2) was observed in broke

24 tory concentration, 7.4 ng/ml), demonstrated high-affinity binding (320 pM), and was capable of thera

25 optimal syntax, whereas enhancers containing high-affinity binding affinities possess suboptimal synt

26 ultivalency-enhanced interactions and create high affinity binding agents.

27 Changes induced by high affinity binding already exist in both a constraine

28 licity changes was essential to achieve both high affinity binding and a stringent targeted absorptio

29 integrity of this interface is critical for high affinity binding and for heterochromatin formation.

30 ptake via FRalpha and -beta, associated with high affinity binding and inhibition of de novo purine n

31 arks within the heptad repeat of the CTD for high affinity binding and provides a molecular interpret

32 ith Unc119a reveals the molecular details of high affinity binding and suggests the importance of the

33 -cGAMP revealed the structural basis of this high-affinity binding and a ligand-induced conformationa

34 tent with a two-step reaction involving fast high-affinity binding and a subsequent slower conformati

35 A fine-tuned balance between high-affinity binding and electrostatic repulsive forces

36 a conformational switch and is essential for high-affinity binding and phosphorylation of EPRS, but n

37 suggesting these probes are preorganized for high-affinity binding and should allow visualization of

38 ingly, a single H830A mutation restores both high-affinity binding and signaling activity with 2'-O-m

39 following extensive washout, consistent with high-affinity binding and slow dissociation from ABL kin

40 ly functional homodimer (or "lysibody") with high-affinity binding and specificity for carbohydrate d

41 strate selection in EAATs and illustrate how high-affinity binding and the efficient transport of glu

42 TonB-dependent transporter that permits the high-affinity binding and transport of cobalamin (CBL),

43 benzothiazole moiety, which greatly enhances high-affinity binding and use-dependent block.

44 t H3R2, H3K4, H3T3, H3T6, and H3S10 disrupts high-affinity binding, and the three most N-terminal ami

45 In solution, the cyanostar shows high-affinity binding as 2:1 sandwich complexes, log bet

46 generated a panel of novel Fc variants with high affinity binding at acidic pH that vary in pH 7.4 a

47 es in BabA and on pH reversible formation of high-affinity binding BabA multimers.

48 Although high affinity binding between streptavidin and biotin is

49 The Satb1 homeodomain is dispensable for high affinity binding but is essential for specificity.

50 Single protein loops can mediate extremely high-affinity binding, but it is unclear whether such a

51 rboxylate of AA with Arg-120 is required for high affinity binding by COX-1 but not COX-2, suggesting

52 This high-specificity and high-affinity binding by NC consequently liberates these

53 ion of stoichiometry and free energy of such high-affinity binding can be far from trivial.

54 High-affinity binding candidates can be produced in a hi

55 d pulsed-EPR measurements, demonstrates that high-affinity binding caused by the CH2-localized mutati

56 These studies indicate high affinity binding, characterized by a low micromolar

57 results in a shift from a low affinity to a high affinity binding conformation of the lectin domain.

58 First, eIF4E binding to eIF4G generates a high-affinity binding conformation of the eIF4F complex

59 a point mutant (alpha-catenin L344P) lacking high affinity binding does not activate vinculin.

60 Such therapeutics typically utilize high-affinity binding domains that have the propensity t

61 ntain multiple occurrences of G(A/G)GGC, the high-affinity binding element for the viral initiator T-

62 The minimal high affinity binding epitope of SL2-1 was alpha1-6 fuco

63 The cloned 12-HETER demonstrated high affinity binding for 12-(S)-[(3)H]HETE (K(d) = 4.8

64 Calcium accumulation assays and high affinity binding for [(3)H]epibatidine determined t

65 ose in other collectins, result in specific, high-affinity binding for GlcNAc.

66 s, and patients whose HLA genetics predicted high-affinity binding had more allergy (P = 3.3 x 10(-4)

67 gnaling, all other mutant receptors retained high affinity binding, indistinguishable from wild-type

68 These modifications facilitate the high affinity binding interaction with IL-6 and provide

69 ombination of E1A aggregation propensity and high-affinity binding interactions.

70 es a basic patch that constitutes a putative high-affinity binding interface spanning both DBL domain

71 High affinity binding is destabilized by osmotic stress,

72 In both cases, high affinity binding is found to involve conformational

73 her ETS domains (e.g., Ets-1, TEL) for which high-affinity binding is driven by rapid association (>1

74 side chain, the pH effect is abolished, and high-affinity binding is observed until LacY is destabil

75 re designed to mimic the profile of ABT-089, high affinity binding ligand for the alpha4beta2 nAChR,

76 4-methylenedioxy-N-methylamphetamine adopt a high-affinity binding mode consistent with a transportab

77 Only the high-affinity binding mode was observed in the complex w

78 By unveiling this high-affinity binding mode, our studies establish a high

79 e PPARgamma agonists with, however, a unique high-affinity binding mode.

80 at unmodified PARP-1 engages in at least two high-affinity binding modes with chromatin, one of which

81 Specific IGF2 and M6P high-affinity binding occurs via domain-11 and domains-3

82 tor because it appears to be responsible for high affinity binding of a number of benzodiazepines to

83 cated network of interactions that result in high affinity binding of all 43 S PIC components with th

84 Gel shift assays confirmed high affinity binding of CsrA to relA mRNA leader and we

85 We demonstrate that the observed high affinity binding of Fab to TNF-alpha is an enthalpy

86 RR31 is an NDH subunit that is necessary for high affinity binding of ferredoxin, indicating that chl

87 Nedd4 and ARRDC3 expressed in HEK293 cells, high affinity binding of full-length ARRDC3 and Nedd4 is

88 e relative and specific titration of IGF2 by high affinity binding of IGF2R represents a mechanism th

89 The results show that high affinity binding of NotD to FVa is membrane-indepen

90 formation on the structural requirements for high affinity binding of organic nitrates to the catalyt

91 Thus, our data (a) indicate that high affinity binding of Pg to Fn is not essential for F

92 High affinity binding of PsbO to PSII is required to pro

93 triads of SRCR domains 2 and 3 abrogates the high affinity binding of recombinant CD163 to Hp-Hb.

94 urface-bound TG2 inactive, whereas specific, high affinity binding of S-nitrosylated TG2 (SNO-TG2) to

95 High affinity binding of short peptide analogs of HVR to

96 These studies revealed high affinity binding of SHP-2 to phosphorylated forms o

97 Our studies revealed high affinity binding of the farnesylated-Cys probe to t

98 inal tail of EIIA(Glc) are essential for the high affinity binding of the protein to the transporter.

99 On the basis of the high affinity binding of trimethoprim (TMP) to Escherich

100 ses are, however, tightly linked because the high affinity binding of urokinase regulates the binding

101 tion binding assays, SET knockdown increased high-affinity binding of agonist in intact cells and mem

102 Our results support the relevance of high-affinity binding of ARF transcription factors to un

103 reliably predict those mutated peptides with high-affinity binding of autologous human leukocyte anti

104 Multimicrosecond simulations of NavAb reveal high-affinity binding of benzocaine to F203 that is a su

105 vity of Ad-FX and Ad-FVII complexes, despite high-affinity binding of both these coagulation factors

106 t sufficient for CaMKII activation, although high-affinity binding of calmodulin is.

107 ndings, here we have successfully introduced high-affinity binding of capsaicin and resiniferatoxin t

108 , and MD-predicted structures shows that the high-affinity binding of Car9 to the silanol-rich surfac

109 n shown that Ca(2+) binding is necessary for high-affinity binding of CBL to BtuB, and earlier simula

110 5 interaction with (NF)G proteins eliminates high-affinity binding of CCR5 chemokines but preserves r

111 re labeling, a supramolecular assay based on high-affinity binding of cucurbit[7]uril, and two colori

112 end targeting of EB1 has been attributed to high-affinity binding of EB1 to GTP-tubulin that is pres

113 Cellulosomes are assembled by selective high-affinity binding of enzyme-borne dockerin modules t

114 We determined sequences that mediate high-affinity binding of ETS-5, VAB-3 and CEH-32.

115 ptor complexes, as they are required for the high-affinity binding of FGF19, FGF21 and FGF23 to their

116 reates a strong thermodynamic driver for the high-affinity binding of guests in aqueous solution for

117 The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO

118 High-affinity binding of heparin/heparan sulfate to the

119 ne through accommodation surfaces may assist high-affinity binding of HIV-1 MPER epitope at membrane

120 Direct high-affinity binding of hPg/plasmin to pattern D GAS is

121 and binding-based reconstitution assays show high-affinity binding of inositol pyrophosphates to the

122 High-affinity binding of InsP(8) to the XPR1 N-terminus

123 recognition of 5-HT, this mutation disrupts high-affinity binding of many competitive antagonists in

124 with the role of Ser438 as a key residue for high-affinity binding of many SSRIs, including (S)-cital

125 The results show high-affinity binding of neomycin to 27-nucleotide model

126 We observed that high-affinity binding of oligonucleotides induces confor

127 into the key molecular determinants for the high-affinity binding of peptide toxins to KCa3.1, and d

128 show that native chemokines fail to prevent high-affinity binding of PSC-RANTES, analog-mediated cal

129 Here, we demonstrate specific, high-affinity binding of quinine to the complementarity-

130 High-affinity binding of RS1-Reg to ODC1 was demonstrate

131 s in increased resistance, probably owing to high-affinity binding of SAP2 to pyrethroid insecticides

132 d surface plasmon resonance studies revealed high-affinity binding of septins to the microtubule plus

133 The high-affinity binding of the AO7 clamp to UbcH5B has als

134 An apparent paradox is that the high-affinity binding of the AO7 clamp to UbcH5B, which

135 It has been shown that high-affinity binding of the BMP10 prodomain to the matu

136 nds of interactions account for the specific high-affinity binding of the c-di-AMP ligand.

137 late strand alignment in the active site for high-affinity binding of the initiating nucleotides.

138 condary repulsive effects contributes to the high-affinity binding of the lin-benzoguanines.

139 In BtuB, the high-affinity binding of TonB(33-239) was eliminated by

140 ation of myeloid dendritic cells induced the high-affinity binding of VCAM-1/CD106 Fc chimeric protei

141 l virulence factors, relying on specific and high-affinity binding of zinc by a periplasmic solute-bi

142 y relying on a polyzwitterion polymer, where high-affinity binding onto the QDs is driven by multicoo

143 luid, we find that galectin-3 is a specific, high-affinity binding partner for lubricin.

144 Our data reveal SPATA2 as a high-affinity binding partner of CYLD and HOIP, and a re

145 Loss of Munc18-1, a high-affinity binding partner of Stx1, also showed sever

146 synthetic auxin derivative 5-Ad-IAA and its high-affinity-binding partner OsTIR1F74A.

147 cking of KARs, Neto1 determined both the KAR high-affinity binding pattern and the distinctively slow

148 We found that both the high-affinity binding pattern in the mouse brain and the

149 eration of new therapeutic molecules such as high affinity binding peptides or modified high affinity

150 Sex hormone-binding globulin (SHBG) is the high-affinity binding protein for androgens and estrogen

151 We created fluorescent sensors that monitor high-affinity binding reactions and used them to study i

152 ing antigens or due to the lack of specific, high-affinity binding reagents and reliable assays with

153 high binding selectivity is associated with high-affinity binding regions, leading to a model where

154 Our results reveal that high-affinity binding requires a distinct sequence and s

155 Our results demonstrate the presence of a high affinity binding site at the enzyme periphery.

156 ged E3 for the proteasome, with a dedicated, high affinity binding site contributed by hRpn10.

157 potentially providing access by TERT to this high affinity binding site during an early step in TERT-

158 lacing multiple permeant ions, en route to a high affinity binding site that remains loosely defined.

159 proteolysis is the driving force to unveil a high affinity binding site(s) for FXa.

160 In addition to a high affinity binding site, SERT possesses a low affinit

161 ses the active state and therefore makes the high-affinity binding site accessible.

162 ttering experiments showed zinc binding to a high-affinity binding site and three low-affinity sites

163 n may result from periodic drug-binding to a high-affinity binding site during the action potentials

164 easing the fraction of channels presenting a high-affinity binding site for PF-05089771 and suggestin

165 93 collectively contribute to establishing a high-affinity binding site for SCF(Slimb).

166 -labeled analogue of stearic acid detected a high-affinity binding site for the fatty acid with stron

167 (3)H]NCS-382, a representative ligand of the high-affinity binding site for the neuroactive substance

168 G) variant repeat predominated and created a high-affinity binding site for the nuclear receptors COU

169 d the open capsid conformation, in which the high-affinity binding site is available, best fit the da

170 l five PCB sulfates were able to bind to the high-affinity binding site of TTR with equilibrium disso

171 re we show that four charged residues in the high-affinity binding site on obscurin for sAnk1 (betwee

172 of HK domain 5 (HKD5) to gC1qR shows only 1 high-affinity binding site per trimer.

173 rmining segment and therefore emergence of a high-affinity binding site resulted in WT-like catalytic

174 the DNA repair protein RAP80 and provides a high-affinity binding site that sequesters the tumor sup

175 tion is necessary and sufficient to reveal a high-affinity binding site with which PF-05089771 intera

176 nteractions with a protein bound to RNA at a high-affinity binding site.

177 ly coordinate zinc and then convey it to the high-affinity binding site.

178 main protein that contains the following two high affinity binding sites for LRP1: one is located wit

179 Liver exhibits high affinity binding sites for RBP4, but specific recep

180 ble for use in agriculture), suggesting that high affinity binding sites were already in excess in th

181 d approximately 0.3 molecules of thrombin at high-affinity binding sites (Kd = 0.15 muM).

182 y of Sox2 and Pax6 demands the relaxation of high-affinity binding sites and is enabled by alternativ

183 ty analogs (medium nanomolar Ki) for the GHB high-affinity binding sites as the most high-affinity an

184 redicted that the pnr enhancer would contain high-affinity binding sites for the Dpp effector Smad tr

185 we used these advances to rapidly mutate 10 high-affinity binding sites for the nucleoid occlusion p

186 bly and desensitization, and incorporate the high-affinity binding sites for zinc and ifenprodil.

187 -out signaling that culminate in exposure of high-affinity binding sites on integrin alpha(IIb)beta(3

188 Combining multiple high-affinity binding sites with the twofold change in F

189 of transient cholesterol clusters around the high-affinity binding sites.

190 ly diminished when we examine only predicted high-affinity binding sites.

191 eceptor 1 (NFR1) bind Nod factor directly at high-affinity binding sites.

192 richment analysis and to define and classify high-affinity binding sites.

193 HB) is a neuroactive substance with specific high-affinity binding sites.

194 inesins, which are open when doing work, the high-affinity binding state for microtubule-depolymerizi

195 at the fast inactivated state represents the high-affinity binding state.

196 These data indicate sequence specificity for high affinity binding, supporting the view that sulfate

197 intensive and mostly limited to elucidating high-affinity binding target proteins.

198 n is weak, its implicit multivalency induces high-affinity binding through avidity.

199 We found that Tmod achieves high-affinity binding through several discrete low-affin

200 Thus, while high affinity binding to 3' ends requires the La domain

201 We identified ECD-scFvhFc, which exhibited high affinity binding to both the isolated ECD and to th

202 calorimetry (ITC) measurements demonstrated high affinity binding to caveolin by the T20 variants wi

203 and brain bioavailability, while maintaining high affinity binding to ERalpha and both potency and ef

204 Ultra-high affinity binding to FcRn at both acidic and neutral

205 we show that each of these domains mediates high affinity binding to ferric heme (hemin) and that it

206 PCBP1 and -2 exhibited high affinity binding to ferritin in vitro.

207 forms functional homo-oligomers that mediate high affinity binding to its corresponding cellular liga

208 antigen receptor for chemokines (DARC) shows high affinity binding to multiple inflammatory CC and CX

209 our mutational data conceivably depended on high affinity binding to Na1.

210 ido-NAADP ([(32)P-5N(3)]NAADP) that exhibits high affinity binding to NAADP receptors.

211 Annexin A5 is a 35-kDa protein with high affinity binding to negatively charged phospholipid

212 ists compete directly with retinoic acid for high affinity binding to purified receptors.

213 al integrity was further demonstrated by its high affinity binding to soluble CD4, CD4 binding site a

214 The Phl p 2-ScFv showed high affinity binding to the allergen and blocked the bi

215 Zinc inhibition through high affinity binding to the ATD has been examined throu

216 These glycoconjugates showed high affinity binding to the human transmembrane lectin

217 procapsid (PC-portal) that is competent for high affinity binding to the large terminase packaging p

218 trating the structural features required for high affinity binding to the receptor.

219 osition 52a in HCDR2 is sufficient to confer high affinity binding to the selecting H1 antigen, consi

220 site-specific glycosylation requirements for high affinity binding to these lectins.

221 e DNA binding interface that is required for high affinity binding to ureA but not nixA.

222 with WDR5 provide structural basis for their high affinity binding to WDR5.

223 at the C terminus of PPXY1, is important for high affinity binding to WW3.

224 en implicated in endocrine disruption due to high affinity-binding to the thyroxine-carrying protein,

225 hort beta2 phospho-peptide is sufficient for high-affinity binding to 14-3-3-zeta.

226 recognition motif (RRM1) are sufficient for high-affinity binding to 3' oligoU, recognition of HCV d

227 ith a binding constant of 18 nM and displays high-affinity binding to a range of SSRIs, SNRIs and a T

228 ow for promiscuity in a protein selected for high-affinity binding to a single target remain unclear.

229 How proteins achieve high-affinity binding to a specific protein partner whil

230 vel class of proteins selected for specific, high-affinity binding to a target protein.

231 ffold and preorganizes CPSF-30 and WDR33 for high-affinity binding to AAUAAA.

232 te-lisinopril complexes possesses a range of high-affinity binding to ACE, introduces the advantage o

233 modularity with particular domains, lack of high-affinity binding to all DNA triplets, and difficult

234 or the chaperone/GEF Ric-8A], while favoring high-affinity binding to all known GBA motifs.

235 n-interacting motif (UIM)-like sequences for high-affinity binding to an alternative ATG8 interaction

236 allergy whereby HLA-DRB1 alleles that confer high-affinity binding to asparaginase epitopes lead to a

237 After initial high-affinity binding to AU-rich elements in 3' untransl

238 (18)F-Tr-Sgc8 was found to possess high-affinity binding to both cell lines, with binding a

239 s elaborated to explore the requirements for high-affinity binding to both TSPO wild type (WT) and th

240 hed the molecular basis of its selective and high-affinity binding to C11/C12-chain fatty acids.

241 how that while the CCD of SA11 NSP4 exhibits high-affinity binding to Ca(2+) at neutral pH and forms

242 ar enzymes, composed of discrete domains for high-affinity binding to cell wall carbohydrates and cle

243 tide and DNA wrapped in MNs is essential for high-affinity binding to chromatin.

244 This RRTRK motif is important for high-affinity binding to DNA and is essential for recogn

245 ture of the polynuclear compounds results in high-affinity binding to DNA and very efficient nuclear

246 -secretase activity is not required and that high-affinity binding to DR6 requires a more C-terminal

247 th and affinity of binding while maintaining high-affinity binding to existing targets, surpassing a

248 anomolar) to both BtuB and FhuA; however, no high-affinity binding to FecA was observed.

249 ation of TM4, eliminates G protein-dependent high-affinity binding to GLP-1(7-36)NH(2) but has select

250 Six of these epitopes exhibited high-affinity binding to HLA-A*02:01 molecules.

251 modified by the enzyme TG2, leading to their high-affinity binding to HLA-DQ2 or HLA-DQ8 molecules, p

252 , and eight of the nine candidates exhibited high-affinity binding to human chemokines.

253 al hydrogen bond in Arabidopsis ARF1 confers high-affinity binding to individual DNA sites.

254 s conformational changes in gp120 that allow high-affinity binding to its coreceptors.

255 d naRNAs, each previously implicated in HU's high-affinity binding to kinked or cruciform DNA, leads

256 s on alpha-dystroglycan that is required for high-affinity binding to laminin.

257 e TP53INP1 LIR peptide, are required for its high-affinity binding to LC3A and LC3B, whereas binding

258 conformational changes in PCSK9 required for high-affinity binding to LDL particles.

259 tifs embedded in miR-122 are responsible for high-affinity binding to Lupus La and sorting into vesic

260 In addition to the expected high-affinity binding to methylated cytosine in the CG c

261 ecessary but not sufficient to maintain this high-affinity binding to N.

262 These MAbs show high-affinity binding to NSP2 and differentially recogni

263 hSSB1 exhibits high-affinity binding to PAR and recognizes iso-ADP ribo

264 resonance experiments they showed comparable high-affinity binding to Phl p 1 as a complete human IgE

265 signal on ER precursors, which also display high-affinity binding to PI(3)P.

266 the oligomannose context is sufficient for a high-affinity binding to receptor CI-MPR, while the pres

267 ed against multiple S. aureus antigens, only high-affinity binding to SpA was observed.

268 ix DNA-binding domains (DBDs) in RPA promote high-affinity binding to ssDNA yet also allow RPA displa

269 units and ribosomal protein S1 alone display high-affinity binding to standby-competent fluorescein-l

270 These compounds showed high-affinity binding to Stat3's SH2 domain, inhibited i

271 mal titration calorimetry analysis confirmed high-affinity binding to STAT3, with K(D) of 880 nM (7g)

272 , slows down SNARE complex formation through high-affinity binding to syntaxin.

273 bispecific antibodies in vivo, we found that high-affinity binding to TfR caused a dose-dependent red

274 an ApoE isoforms attenuated CCC activity via high-affinity binding to the activated CCC-initiating C1

275 the growth of prostate cancer cells through high-affinity binding to the AR and inhibition of AR nuc

276 my virus long terminal repeat (LTR) that has high-affinity binding to the CCCTC-binding factor.

277 gnizes a receptor on the host cell, enabling high-affinity binding to the cell surface, after which t

278 Furthermore, we found that the NTD exhibits high-affinity binding to the chaperone-adhesin (PapDG) c

279 guanosines essential for both packaging and high-affinity binding to the cognate Gag protein are exp

280 o group by SimC7 was shown to be crucial for high-affinity binding to the enzyme.

281 etworks and basement membranes (BMs) through high-affinity binding to the laminin gamma1 chain.

282 We confirm the hypothesis that methoctramine high-affinity binding to the M(2) receptors involves sim

283 hate 4-phosphatase domain of P-REX2 provides high-affinity binding to the postsynaptic density-95/Dis

284 ctivities of these metal complexes and their high-affinity binding to the targeted RRE mRNA following

285 s occupancy of both subsites is required for high-affinity binding to TRIP13.

286 to the cell surface, and further facilitate high-affinity binding to virus-specific cell-surface rec

287 WDR5 establishes their structural basis for high-affinity binding to WDR5.

288 The resulting antibody, Ab513, exhibits high-affinity binding to, and broadly neutralizes, multi

289 icroarray, the MGL(short) H259T variant lost high-affinity binding toward Tn-containing glycopeptides

290 st, LacY mutants that exhibit pH-independent high-affinity binding up to pH 11.0 (e.g., Glu325 --> Gl

291 liI homologs from diverse bacterial species, high affinity binding was also observed for the type III

292 As well as being required for high affinity binding, we also demonstrate that the Arg-

293 lex that drive heterodimeric specificity and high affinity binding, we carried out biophysical analys

294 o explore the criteria for ligand economical high affinity binding, we systematically probed distance

295 identify molecular targets for specific GHB high-affinity binding, we undertook photolinking studies

296 correlation between the energies of low- and high-affinity binding, which implies that gating commenc

297 While GIC elements responsible for its high affinity binding with Ac-AChBP and alpha3beta2 nACh

298 , we predict and then experimentally confirm high-affinity binding with multiple other HLA-A*02 subty

299 oligosaccharide context are all critical for high-affinity binding with the major M6P receptor.

300 identified molecular features important for high-affinity binding, with high predictive validity.