ライフサイエンスコーパス: high-affinity ligand

1 mammalian cells depends on the presence of a high affinity ligand.

2 mall protein scaffold in order to identify a high affinity ligand.

3 transforms consensus sequence peptides into high affinity ligands.

4 ormational change in the protein, leading to high affinity ligands.

5 by deriving a plausible binding pose for the high affinity ligands.

6 iciently high to enable in vivo imaging with high affinity ligands.

7 er a successful strategy for the creation of high-affinity ligands.

8 al its functional interaction interface with high-affinity ligands.

9 sed screening approach for rapidly modifying high-affinity ligands.

10 ligands, and with Hg(Cys)2, which has bulky, high-affinity ligands.

11 idly combinatorial mixtures of compounds for high-affinity ligands.

12 e when tuning selection pressures to isolate high-affinity ligands.

13 e in the generation of memory in response to high-affinity ligands.

14 s model, we found that AHR activation by the high-affinity ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin

15 s factor receptor superfamily and binds to a high-affinity ligand (4-1BBL) expressed on several antig

16 ively express AhR, and its activation by the high-affinity ligand 6-formylindolo[3,2-b]carbazole (FIC

17 The binding of a high affinity ligand, Ac-Asp-Ala-Asp-Glu-F(2)Pmp-Leu-NH(

18 yl azelaoyl phosphatidylcholine (azPC), as a high affinity ligand and agonist for PPARgamma.

19 developed a method to quantitatively select high affinity ligands and applied the Stabilized Peptide

20 se, but foreign peptides can incidentally be high affinity ligands and can therefore stimulate T cell

21 3beta-Adiol is a high-affinity ligand and agonist of ERbeta and is derive

22 is well established that the monomer is the high-affinity ligand and that the interactions between t

23 hesis and time required for the discovery of high-affinity ligands and appears particularly useful in

24 16 structures of PDZ domains in complex with high-affinity ligands and have elucidated four additiona

25 tners, and in experiments comparing low- and high-affinity ligands and oncogenic EGFR mutants.

26 labeling, is suited to the slow kinetics of high-affinity ligands, and has agonist binding, which ha

27 CCCC and CCAA with Hg(CN)2, which has small, high-affinity ligands, and with Hg(Cys)2, which has bulk

28 Cs might determine local availability of its high-affinity ligand APRIL, because sBCMA has been shown

29 nnel are poorly understood because selective high affinity ligands are not available, and the thresho

30 monstrated that, when high concentrations of high affinity ligands are used in this RC system, double

31 se receptors, more selective small-molecule, high-affinity ligands are needed for a better understand

32 Similar high-affinity ligands are rarely available for most rece

33 olding state can be reversibly tuned using a high affinity ligand, as model substrates to interrogate

34 JMV-180 ( 1) and CCK-8(s) are high affinity ligands at the CCK 1 receptor that have si

35 s model will be useful for the prediction of high-affinity ligands at radiolabeled H(1) receptors in

36 e anticipated to be useful for the design of high affinity ligand based probes of siglec function.

37 steines play a critical role in removing the high-affinity ligands before Hg(II) reaches the redox-ac

38 for which lysophosphatidylcholine (LPC) is a high affinity ligand, belongs to a newly defined lysopho

39 ntegrin beta cytoplasmic tails (CTs) induces high affinity ligand binding (integrin activation), wher

40 of the receptor was critically important for high affinity ligand binding activity.

41 ntegrin extracellular domain is required for high affinity ligand binding and is also involved in pos

42 s require different sets of interactions for high affinity ligand binding and receptor activation.

43 ly(6.55)) as a critical residue required for high affinity ligand binding and receptor function.

44 c), a subunit of the IL-2R, is essential for high affinity ligand binding and signal transduction due

45 e charge at the C1 position is essential for high affinity ligand binding and that the charge at this

46 ses, we show that the motif is necessary for high affinity ligand binding as well as function.

47 While high affinity ligand binding has been attributed to the

48 e presence of the appropriate LIBS antibody, high affinity ligand binding of the constrained receptor

49 complexes in the extended conformation, the high affinity ligand binding pocket between domains I an

50 this aspartate ring also contributes to the high affinity ligand binding site.

51 r reveal the mechanism by which TACI engages high affinity ligand binding through a single CRD, and w

52 High affinity ligand binding to alphaIIb/beta3 triggers

53 ated protein (RAP), a universal inhibitor of high affinity ligand binding to LRP, to evaluate the par

54 When Asp(374) was substituted by alanine, high affinity ligand binding was abolished and inhibitio

55 nist-mediated receptor activation but not in high affinity ligand binding.

56 arge extracellular (EC) sequence forming the high-affinity ligand binding domain.

57 These results suggest that high-affinity ligand binding is an intrinsic property of

58 This high-affinity ligand binding process is unique among the

59 he case of the glucocorticoid receptor (GR), high-affinity ligand binding requires the interaction of

60 High-affinity ligand binding was demonstrated with both

61 These studies showed that high-affinity ligand binding was sufficient for DT388-GM

62 ed Bpa-substituted Ste2p receptors exhibited high-affinity ligand binding, and incorporation of Bpa i

63 gen atoms provides a significant barrier for high-affinity ligand binding.

64 nd R7.67 produced mutant receptors that lost high-affinity ligand binding.

65 6-alpha7 loop and alpha7-helix, required for high-affinity ligand binding.

66 s a 15 nucleotide motif that is required for high-affinity ligand binding.

67 inhibitors, suggesting that they target the high affinity ligand-binding pocket of EphA4 and inhibit

68 he beta subunit to form a heterodimer with a high affinity ligand-binding site.

69 phaXbetagamma complex was able to induce the high affinity ligand-binding state in the N-formyl pepti

70 ipated in Hsp-ER-alpha complex, enhanced the high-affinity ligand-binding capacity of ER-alpha, and s

71 chemokine activation of CXCR3 involves both high-affinity ligand-binding interactions with negativel

72 This substitution disrupted the high-affinity ligand-binding interface of the prolactin

73 arization, whereas activation of Alk1 by its high-affinity ligand BMP9 rescues hypersprouting induced

74 Its high-affinity ligand, bone morphogenetic protein 9 (BMP9

75 four major effects: first, the definition of high affinity ligands both for T cells and antibodies; s

76 etric dimer of Drosophila EGFR with a single high-affinity ligand bound and provides a model for sing

77 secutive steps: (i) a gel-shift selection of high-affinity ligands bound to the AChR in the electropl

78 Nicotinic acid is a high affinity ligand, but the endogenous ligand is still

79 or family members, HER-2/neu does not bind a high-affinity ligand, but rather functions as the prefer

80 established that the monomer functions as a high-affinity ligand, but the binding affinity of the di

81 G8 with weak affinity, was converted into a high-affinity ligand by a single point mutation.

82 nt development of in vitro methods to select high-affinity ligands by combinatorial chemistry methodo

83 The development of high-affinity ligands capable of selectively recognizing

84 In addition, its high-affinity ligand CD155 was upregulated in mediastina

85 nds at overlapping epitopes, we hypothesized high affinity ligands compete with low affinity ligands

86 ue virus NS2B-NS3 protease in complex with a high-affinity ligand containing a tert-butyl group.

87 by alpha5beta1 integrin interaction with its high-affinity ligand CRRETAWAC in murine and human MSCs

88 VACV-138 also abrogated D8 binding to the high-affinity ligand CS-E, but we observed residual CS-E

89 ded the bile acid pool enriched with the FXR high affinity ligand, DCA.

90 We show activin A and other high affinity ligands directly inhibited signaling by th

91 Activation of AHR by a high-affinity ligand during T(H)17 cell development mark

92 of the binding thermodynamics of hydrophobic high-affinity ligands employing a new calorimetric compe

93 ty of BGC 945 for the alpha-FR is 70% of the high-affinity ligand folic acid.

94 Here we show that RA is a high affinity ligand for another nuclear receptor, namel

95 ich binds only retinoic acid receptors, is a high affinity ligand for both retinoic acid receptors an

96 It is a high affinity ligand for cancer cell targeting.

97 the CD2 subset of the Ig superfamily, is the high affinity ligand for CD48.

98 and patterning in the developing head, is a high affinity ligand for Cubn.

99 FGF18, a high affinity ligand for FGFR3, is the only FGF-based dr

100 VEGF-A, expressed in the epithelium, is a high affinity ligand for Flk-1.

101 Instead, the high affinity ligand for mouse CD22 has N-glycolylneuram

102 of compounds has been developed based on the high affinity ligand for nAChRs, 2-chloro-5-((1-methyl-2

103 resulted in strong down-regulation of H60, a high affinity ligand for NKG2D, from the surface of viru

104 The major high affinity ligand for P-selectin on human leukocytes

105 plasmon resonance (SPR) confirmed it to be a high affinity ligand for Robo1.

106 reconstituted HDL particles, functions as a high affinity ligand for SR-BI.

107 omain of laminin alpha4 chain is a specific, high affinity ligand for the alphavbeta3 and alpha3beta1

108 bitory factor (LIF), a previously identified high affinity ligand for the cation-independent mannose

109 The peptide growth factor apelin is the high affinity ligand for the G-protein-coupled receptor

110 ng protein from rabbit and rat brain using a high affinity ligand for the I(2) subtype, 2-BFI, to gen

111 he discovery of H-Phe-Phe-NH2 as a small and high affinity ligand for the substance P 1-7 (SP(1-7), H

112 for this approach is the identification of a high affinity ligand for the target Siglec.

113 Our findings suggest that, in the absence of high affinity ligand for the TCR, the CD28-B7.2 system p

114 we show that human R-spondin1 (hRspo1) is a high affinity ligand for the Wnt co-receptor LRP6 (K(d)

115 osttranslational modification by itself is a high affinity ligand for XRCC1, requiring a minimum chai

116 tizing thiazolidinedione (TZD) compounds are high affinity ligands for a member of the nuclear recept

117 strate that 7-oxygenated sterols function as high affinity ligands for both RORalpha and RORgamma by

118 lass of oxidized phospholipids that serve as high affinity ligands for CD36 and mediate recognition o

119 ospholipids (oxPC(CD36)) that serve as novel high affinity ligands for cells stably transfected with

120 is approach with the discovery of selective, high affinity ligands for CLL BCRs of the aggressive, st

121 to these cells was not competed by the other high affinity ligands for CXCR3, monokine induced by IFN

122 or multivalency is widely applied to achieve high affinity ligands for diagnostic and therapeutic pur

123 D45 requires expression of core 2 O-glycans (high affinity ligands for galectin-1), galectin-1 signal

124 ession pattern correlates with expression of high affinity ligands for L-selectin.

125 n mouse skin, it is now clear that different high affinity ligands for PKC have distinct biological e

126 d to the identification of a number of novel high affinity ligands for RXRalpha.

127 vo at sites of oxidative stress and serve as high affinity ligands for scavenger receptors class B (C

128 ethylpyrrolidinyl analogues were found to be high affinity ligands for the CB1 and CB2 cannabinoid re

129 Hence, the generation of rhGAA containing high affinity ligands for the CI-MPR represents a strate

130 These compounds were shown to be high affinity ligands for the ER with nanomolar IC50 bin

131 ioactive cyclic N-methylated hexapeptides as high affinity ligands for the integrin alphavbeta3 is ba

132 oxPC(CD36) serve as high affinity ligands for the scavenger receptor CD36, m

133 ine ANV indicated that low concentrations of high affinity ligands for the TCR were efficient inducer

134 Donepezil is a high-affinity ligand for acetylcholinesterase-the enzyme

135 erotype of foot-and-mouth disease virus is a high-affinity ligand for alpha v beta 6, and we recently

136 turally related to (+)-ryanodine, which is a high-affinity ligand for and modulator of ryanodine rece

137 vascular cell adhesion molecule-1 (VCAM-1) a high-affinity ligand for apha4beta1, and that VCAM-1 med

138 ration-inducing ligand" (APRIL) is a natural high-affinity ligand for BCMA and transmembrane activato

139 anisotropy approach, PEA-15 is shown to be a high-affinity ligand for both ERK1 and 2, exhibiting a d

140 novel fibrate, designated GW2331, that is a high-affinity ligand for both PPARalpha and PPARgamma.

141 sults demonstrate that only the monomer is a high-affinity ligand for both receptors, and also provid

142 ncentrations of CCL2 (also known as MCP1), a high-affinity ligand for CCR2, are elevated in obesity,

143 atibility 2, Q region locus 10 (H2-Q10) is a high-affinity ligand for CD8alphaalpha which also binds

144 , Pachymedusa dacnicolor, and validated as a high-affinity ligand for CRF receptor studies.

145 Reports of a high-affinity ligand for E-selectin, sialyl di-Lewis(x)

146 though a lipid metabolite, lipoxin A4, was a high-affinity ligand for FPRL1, it was not reported to i

147 We show that LPC is a high-affinity ligand for G2A, a lymphocyte-expressed G p

148 , the major elicitor-releasing isozyme, is a high-affinity ligand for GIP1, which completely inhibits

149 bean endoglucanases: EGaseA, which acts as a high-affinity ligand for GIP1; and EGaseB, with which GI

150 a novel nonthiazolidinedione identified as a high-affinity ligand for human PPAR-gamma.

151 ora-3a,4a-diaza-s-indacene (BODIPY FL), as a high-affinity ligand for human PXR with a Kd value of 67

152 s, compound 5a (GSK8470) was identified as a high-affinity ligand for LRH-1 and SF-1.

153 We report that Dkk-1 is a high-affinity ligand for LRP6 and inhibits Wnt signaling

154 This compound was found to be a high-affinity ligand for MCHr1 and a potent inhibitor of

155 demonstrated that soluble NE is a specific, high-affinity ligand for NRP1 with a calculated Kd of 38

156 We characterized a high-affinity ligand for P450 2D6, also devoid of a basi

157 ProNGF is a high-affinity ligand for p75(NTR) with high affinity and

158 ifferent plasma lipoproteins and serves as a high-affinity ligand for several receptors.

159 le, we report the development of a selective high-affinity ligand for Siglec-G and its application as

160 ine-glycine-aspartic acid) peptide that is a high-affinity ligand for the alphavbeta3 integrin.

161 fructose 2,6-bisphosphate and cyclic AMP, a high-affinity ligand for the AMP/ADP binding site.

162 ddition of the HIV-1 Nef protein, which is a high-affinity ligand for the Hck SH3 domain, to either t

163 ry N-acetyl galactosamine (GalNAc, GN3: ), a high-affinity ligand for the hepatocyte-specific asialog

164 d supertypic epitope C2, which constitutes a high-affinity ligand for the inhibitory natural killer (

165 dinated to 3,5,3'-triiodothyronine (T(3)), a high-affinity ligand for the nuclear TH receptors TR alp

166 ing from the phosphorylated dipeptide (2), a high-affinity ligand for the p56lck SH2 domain, we have

167 Hybrid peptides consisting of a high-affinity ligand for the peptide-binding site of hsp

168 15d-PGJ(2) is a high-affinity ligand for the peroxisome proliferator-act

169 f fluoro furanyl norprogesterone (FFNP) 1, a high-affinity ligand for the progesterone receptor (PgR)

170 on of a distinct drug clearance program by a high-affinity ligand for the related nuclear receptor, t

171 Recently, we reported that LGD1069, a high-affinity ligand for the retinoid X receptors (RXRs)

172 Targretin (LGD1069; a high-affinity ligand for the retinoid X receptors) is an

173 macological studies showed that Ucn III is a high-affinity ligand for the type 2 CRF receptor (CRF-R2

174 using 125I-linear-AVP, which is a selective high-affinity ligand for the V1a receptor, we found earl

175 represents a powerful method of identifying high-affinity ligands for a broad range of molecular tar

176 g solubilized membranes show oligomers to be high-affinity ligands for a small number of nonabundant

177 structural biology is the identification of high-affinity ligands for arbitrary receptors.

178 ng strategy for template-driven selection of high-affinity ligands for biological targets from equili

179 has emerged as a successful method to design high-affinity ligands for biomacromolecules of therapeut

180 d choline glycerophospholipids that serve as high-affinity ligands for CD36 were at markedly increase

181 ty of using N6-modified ATP/ADP analogues as high-affinity ligands for CFTR gating, since these analo

182 imal models, ADM and PanINs are initiated by high-affinity ligands for EGF-R or activating Kras mutat

183 fen (TAM), and 4-hydroxytamoxifen (4-OHT) as high-affinity ligands for ERR gamma.

184 Our findings show that PCB sulfates are high-affinity ligands for human TTR and therefore indica

185 oforms of the neurotrophins are preferential high-affinity ligands for p75NTR and potent inducers of

186 acylglycerol (DAG) lactones, which behave as high-affinity ligands for protein kinase C (PK-C), have

187 tro selection methods to identify drug-like, high-affinity ligands for protein targets of interest.

188 pected to have increased chances of yielding high-affinity ligands for proteins, and they suggest tha

189 sation is integral to the rational design of high-affinity ligands for proteins.

190 nding proteins, led to the identification of high-affinity ligands for siglec-9 and siglec-10.

191 d synthetic HDL-like nanoparticles (HDL NP), high-affinity ligands for SR-B1, to carry a fluorescentl

192 The search for high-affinity ligands for studying such interactions inv

193 These peptides are the first high-affinity ligands for tetrodotoxin-resistant periphe

194 In our effort to develop high-affinity ligands for the dopamine transporter which

195 These results demonstrate the existence of high-affinity ligands for the ERR family of orphan recep

196 that certain tetrasubstituted pyrazoles are high-affinity ligands for the estrogen receptor (ER) and

197 dized phospholipids that serve as endogenous high-affinity ligands for the macrophage scavenger recep

198 cted to help considerably the development of high-affinity ligands for TSPO-based therapies or diagno

199 ed hydroxylated PCB metabolites (OH-PCBs) as high-affinity ligands for TTR, but the binding potential

200 TA and OA are high-affinity ligands for TYRA-3 and F14D12.6, respectiv

201 d the outnumbered clusters engendered by the high-affinity ligands from launching the more complete c

202 S analysis revealed that the presence of the high affinity ligand GM1 (at substoichiometric amounts r

203 No high affinity ligand has yet been reported for this rece

204 kinase C (PKC) binding to several classes of high-affinity ligands has been investigated through comp

205 ominant due the presence of large amounts of high-affinity liganded hemoglobin dimers.

206 ELC, SLC, and TECK comprised high affinity ligands (IC50 <15 nM); lower affinity liga

207 There are more high-affinity ligands (IC50 < 1 micromol/L) derived from

208 dless of ligand density, like a low density, high affinity ligand in all these parameters.

209 al over time allows T cell activation with a high-affinity ligand in the absence of CD8 engagement.

210 amily kinase Hck, SH3 was unable to engage a high-affinity ligand in trans and that interaction with

211 surprise, we find that even single copies of high-affinity ligands in a pool of billions can strongly

212 nism whereby alpha5beta1 integrin priming by high-affinity ligands integrates Wnt/beta-catenin signal

213 type of the DeltaL8TbpA mutant suggests that high-affinity ligand interaction is required for transfe

214 In both species, the high affinity ligand is based on the sequence Siaalpha2-

215 eged" substructure concept for the design of high-affinity ligands is presented, and an example of th

216 This represented a high affinity ligand (K(i) = 56 +/- 8 nM) that was a pot

217 ively eliminated by itraconazole, which is a high-affinity ligand known to coordinate to the heme iro

218 since direct access of HgX2 substrates with high-affinity ligands leads to formation of an inhibited

219 Circular dichroism demonstrated that high affinity ligands (long chain fatty acyl-CoAs, unsat

220 s suggested that, when present together with high affinity ligands, low affinity GSL ligands can cont

221 The chemokine receptor, CCR5, and its three high-affinity ligands, macrophage inflammatory protein-

222 Ala), while the high affinity site binds the high affinity ligand Manalpha(1-2)Manalpha with a K(d) v

223 ryl hydrocarbon receptor (AhR) activation by high-affinity ligands mediates immunosuppression in asso

224 Addition of a high affinity ligand mimetic peptide or Mn(2+) results i

225 Finally, a high affinity ligand-mimetic compound stabilized noncova

226 The high affinity ligand N-acetylmannosamine (ManNAc) binds

227 The structures disclosed that the high-affinity ligand N-acetyl-d-glucosamine (GlcNAc) bin

228 4-positive cells, suggesting that gp120 is a high affinity ligand of CXCR4.

229 that the endogenous lipid mediator AGP is a high affinity ligand of PPARgamma but that it binds via

230 results indicate that PPT-C encodes another high affinity ligand of the NK1 receptor which may play

231 ow that 20-mer peptide ligands, derived from high affinity ligands of alpha v beta6 (foot-and-mouth-d

232 Neurocan and phosphacan are also high affinity ligands of amphoterin and HB-GAM (Kd = 0.3

233 the thiazolidinediones (TZ), which are also high affinity ligands of peroxisome proliferator-activat

234 Although all are high affinity ligands of the human receptor (K(i) <5 nm)

235 studies resulted in the discovery of several high affinity ligands of which compound 22 showed the hi

236 s activities, p17 mimicked IL-8, the natural high-affinity ligand of CXCR1.

237 ondeamidated precursor, and (iv) a reference high-affinity ligand of HLA-DQ2 that is not recognized b

238 Phosphatidylinositol 3,4,5-trisphosphate, a high-affinity ligand of JFC1 did not affect its ATPase k

239 w that the INS region in HIV-1 gag mRNA is a high-affinity ligand of p54nrb/PSF, a heterodimeric tran

240 ion for binding to the molecule CCdApPuro, a high-affinity ligand of ribosomal peptidyl transferase d

241 nd diabetic rat hearts with rosiglitazone, a high-affinity ligand of the peroxisome proliferator-acti

242 Pase-activating protein (GAP) for Rab7, is a high-affinity ligand of the retromer cargo selective com

243 High-affinity ligands of enzymes are much larger than th

244 protein-tyrosine phosphatase-zeta/beta), are high-affinity ligands of tenascin-C.

245 ple modification of fullerenes can result in high-affinity ligands of the HIV protease, for which the

246 osine phosphatase-zeta/beta were found to be high-affinity ligands of the neural cell adhesion molecu

247 Positive beads that carry high-affinity ligands of the SH2 domains were identified

248 st the SH2 domains, and the beads that carry high-affinity ligands of the SH2 domains were identified

249 phosphatase SHP-1, and the beads that carry high-affinity ligands of the SH2 domains were identified

250 ic acid (Neu5Ac) as the sialic acid, and the high affinity ligand on naive B-cells contains 6-O-sulfa

251 we show in both mice and humans that loss of high affinity ligands on GC B-cells unmasks the binding

252 bules bind proteins in a specific manner via high affinity ligands on the polar head groups of the li

253 proteomics initiatives is the production of high affinity ligands or probes that specifically recogn

254 The functional activity of high-affinity ligands ranged from antagonist to full ago

255 e closely resembles the pyranose ring in the high-affinity ligands rapamycin and FK506.

256 he contribution of Arg(120) and Glu(121) for high-affinity ligand-receptor interactions is essential,

257 High-affinity ligands recognizing biomolecules with high

258 structurally related PBR ligands, including high-affinity ligands Ro5-4864 and PK11195, failed to in

259 (<2 kDa) molecules (referred to as selective high-affinity ligands [SHALs]) to mimic the targeting pr

260 A high-affinity ligand specific for mHTT aggregates could

261 We conclude that the high-affinity ligand SPP specifically induces the revers

262 0, a low-affinity ligand, but still binds to high-affinity ligands, such as Mad1 and MBP1, forming li

263 Previous studies suggested that high affinity ligands targeting M cells may be used to d

264 Herein, we describe the design of high affinity ligands that bind expanded rCUG and rCAG r

265 strategy to inhibit amyloidosis is to design high affinity ligands that specifically increase the sta

266 l)furan-2-carboxamide], a positron-emitting, high-affinity ligand that is specific for the macrophage

267 al features relevant to the design of novel, high-affinity ligands that are family and subtype specif

268 Thus far, there are no high-affinity ligands that directly target any inward-re

269 ep toward this goal is the identification of high-affinity ligands that stabilize an sGC conformation

270 nd at pH 6.5 (i.e. trans Golgi network) to a high affinity ligand (the terminally phosphorylated tris

271 ility, we examined whether the addition of a high affinity ligand to rhGAA would improve its delivery

272 r, REDOR NMR requires strategically labeled, high affinity ligands to determine interlabel distances

273 High affinity ligands to human IFN-gamma from each modif

274 ed displacement assay, however, requires the high-affinity ligand to be soluble at high concentration

275 change labeling-quench strategy, employing a high-affinity ligand to displace Cdc42 from WASP, was us

276 ration of distinct modes of docking the same high-affinity ligand to highly homologous receptors.

277 The ratio of each high-affinity ligand to its individual target within a p

278 This method is based on the coupling of a high-affinity ligand to the binding of the low-affinity

279 We tested these ideas by isolating high-affinity ligands to human keratinocyte growth facto

280 chnology as a method for producing specific, high-affinity ligands to proteins.

281 However, identification of high-affinity ligands to serve as PROTAC starting points

282 A method for the rapid identification of high-affinity ligands to Src homology-2 (SH2) domains is

283 ilicity of VSDs by dynamic encapsulation and high-affinity ligands to target the construct to specifi

284 gives a greatly reduced rate of selection of high-affinity ligands to that target.

285 g the groundwork for discovery and design of high-affinity ligands to this class of cofactor-independ

286 ntially applicable to any pro- or eukaryotic high-affinity ligand transport process.

287 Antisense oligonucleotides may be coupled to high-affinity ligands (triantennary N-acetyl galactosami

288 id structural basis for the design of novel, high-affinity ligands useful in modulating the activity

289 zation of ActRIIB binding to several low and high affinity ligands using a soluble activin receptor t

290 A strategy is described for designing high-affinity ligands using information derived from the

291 High affinity ligands were able to reverse a reduction i

292 The AR agonist and antagonist activities of high-affinity ligands were determined by the ability of

293 High-affinity ligands were discovered for recombinant hu

294 High-affinity ligands were identified by replacing the 6

295 d to identify hL-FABP ligands, and all eight high-affinity ligands were selectively captured from 74

296 Thus, high affinity ligands, when presented to DP thymocytes b

297 a route to simultaneously bias pools toward high-affinity ligands while reducing the demand for targ

298 e and phenyl-2-aminoimidazoline compounds as high affinity ligands with conflicting functional activi

299 forms of the insulin hexamer, the design of high-affinity ligands with a carboxylate donor for coord

300 ies against fresh human colonic adenomas for high-affinity ligands with preferential binding to prema