ライフサイエンスコーパス: high-resolution structure

1 o the lack of homology to other proteins and high-resolution structure.

2 er mechanisms - has not been observed in any high-resolution structure.

3 myoglobin was the only protein with a known high-resolution structure.

4 f PDE6, and each domain was readily fit with high resolution structures.

5 ny years was characterized by the paucity of high-resolution structures.

6 is and other biological processes, many lack high-resolution structures.

7 fall within the footprints identified by our high-resolution structures.

8 ive KOW domains in Spt5, and a lack of their high-resolution structures.

9 roscopy (cryo-EM) as a technique to generate high-resolution structures.

10 ine receptors has been hindered by a lack of high-resolution structures.

11 d structures are in very good agreement with high-resolution structures.

12 m of ZnT8 remains unclear due to the lack of high-resolution structures.

13 e protein backbone rather than of individual high-resolution structures.

14 We present here a high resolution structure (1.55 A) of ZIKV NS5 methyltra

15 Here, we report the first high-resolution structure (1.92A) of UP1 bound to a 5'-A

16 The high-resolution structure allowed us to identify putativ

17 his map, combined with previously determined high resolution structures and molecular dynamics simula

18 This high-resolution structure and accompanying functional an

19 Ultra-high-resolution structure and composition analysis via s

20 We present a high-resolution structure and dynamics of Ixolaris and d

21 ther facilitate its use by the community for high-resolution structure and function prediction.

22 es cerevisiae (yeast) and humans, aided with high-resolution structures and biochemical characterizat

23 ns in disease-related variants, knowledge of high-resolution structures and dynamics of C domains is

24 mportant HRD motif deviates from ideality in high-resolution structures and the strained geometry res

25 Outcomes reconcile low- and high-resolution structures and yield a partial sequentia

26 High resolution structures are available for individual

27 st of the prokaryotic transporters for which high-resolution structures are available.

28 DEBS, as well as a set of domains for which high-resolution structures are available.

29 e find that the constructs upon which extant high-resolution structures are based predominantly occup

30 High-resolution structures are essential for rational dr

31 All available high-resolution structures are of homopentameric recepto

32 Their flexibility limits both the number of high-resolution structures available, leaving only a sma

33 ected by yeast surface display combined with high-resolution structure-based predictions, and validat

34 The former can produce high-resolution structures but is limited to highly puri

35 ing the smallest protein crystals to yield a high-resolution structure by X-ray crystallography to da

36 ty of pure RNAs makes it difficult to obtain high-resolution structures by cryo-EM.

37 Complete data sets and resulting high-resolution structures can be obtained from a single

38 aled that with this supramolecular approach, high-resolution structures can be written that show unpr

39 these fusion protein TMDs have so far eluded high-resolution structure characterization because of th

40 intact SARS-CoV-2 virions and determine the high-resolution structure, conformational flexibility an

41 complexes recently revealed that all current high-resolution structures correspond to downstream stat

42 exemplified in homomeric structures, but no high-resolution structure currently exists of heteromeri

43 Thereby, the comparison of their high-resolution structures defines the mechanistic and s

44 Our high-resolution structures delineated the altered PAM re

45 sting technical difficulties associated with high resolution structure determination of transmembrane

46 spectroscopy and outline a strategy for the high-resolution structure determination and positioning

47 m in their native conformation and allow for high-resolution structure determination by cryo-electron

48 evelopments that led to this breakthrough in high-resolution structure determination by cryo-EM and p

49 r nanocrystals can provide a simple path for high-resolution structure determination by the cryoEM me

50 High-resolution structure determination crucially depend

51 ces in cryo-electron microscopy have enabled high-resolution structure determination of AAA+ proteins

52 "developing cryoelectron microscopy for the high-resolution structure determination of biomolecules

53 P) crystallization has proven successful for high-resolution structure determination of challenging m

54 The characterization and high-resolution structure determination of this enzyme s

55 imaging, improves image quality, and allows high-resolution structure determination with a minimum o

56 thologies that render them inappropriate for high-resolution structure determination.

57 tly celebrate the maturation of cryo-EM as a high-resolution structure-determination tool, I believe

58 The resulting high-resolution structure displays metrical parameters c

59 plicity of biological sample preparation for high-resolution structure elucidation by cryo-EM.

60 High-resolution structure elucidation has been challengi

61 graphy to medicine was evident, as the first high-resolution structures emerged in the 50s and 60s.

62 Although high-resolution structures exist for AcrB, its conformat

63 ational rearrangements during translocation, high-resolution structures exist for essentially only on

64 No structural homologs or high-resolution structure exists for the TP domain.

65 Currently, no high-resolution structure exists for this region, limiti

66 espite its importance, there is currently no high resolution structure for subunit a of the V-ATPase.

67 nts in experimental techniques are revealing high resolution structures for an increasing number of m

68 This first high-resolution structure for a kobuvirus is intermediat

69 In the absence of a high-resolution structure for either PfENT1 or a homolog

70 y, the solid state NMR data lead to a unique high-resolution structure for the dimerization interface

71 We have determined a high-resolution structure for the rotavirus VP1 RdRp in

72 Herein, we provide high-resolution structures for an EAL enzyme Bd1971, fro

73 There are no high-resolution structures for any of the ToxB homologs,

74 Despite having high-resolution structures for eukaryotic large ribosoma

75 We recently reported the first high-resolution structures for heterochiral coiled-coil

76 The transmembrane surfaces of all available high-resolution structures for K(+) channels were swept

77 High-resolution structures for tetramers of two blades,

78 This high-resolution structure guided targeted mutagenesis at

79 nsitive to these modulators, and for which a high resolution structure has been solved.

80 ionality and plasticity, but for decades its high-resolution structure has remained elusive.

81 Isolating virions for determining high-resolution structures has been hindered by latency-

82 In recent years, a number of high resolution structures have supported this general f

83 their isolation from infected tissue and no high resolution structures have yet been reported.

84 High-resolution structures have been solved for an allos

85 High-resolution structures have not been reported for re

86 resented a number of challenges, but several high-resolution structures have now become available.

87 Although high-resolution structures have provided atomic details

88 While previous high-resolution structures have provided insights into t

89 High-resolution structures have revealed intricate detai

90 X-ray crystallography can reveal high resolution structures; however, one perceived limit

91 High-resolution structured illumination microscopy (SIM)

92 High-resolution structured illumination microscopy sugge

93 rast to G proteins, for which there are many high-resolution structures in complex with GPCRs, the mo

94 By probing recent high-resolution structures in the context of functional

95 sequence-dependent features of DNA found in high-resolution structures introduce irregularities in t

96 Despite their importance, only one high-resolution structure is available for SPs within pr

97 structure of cpSRP43 has been determined, no high-resolution structure is yet available for cpSRP54.

98 ance (NMR) spectroscopy, the availability of high-resolution structures is limited owing to the frequ

99 The high-resolution structures made possible the identificat

100 Regardless, high-resolution structures obtained from XFEL data mostl

101 dely investigated as potential therapeutics, high-resolution structures obtained under biologically r

102 Unfortunately, efforts toward a high resolution structure of full-length apoA-I have not

103 There is no high resolution structure of human P-gp, but homology mo

104 utations was analyzed by comparison with the high resolution structure of Sphingomonas sp. A1-III alg

105 High resolution structure of synthetic alpha-pheromone f

106 The high resolution structure of the metal-bound variant ill

107 We recently reported the high resolution structure of the N-terminal domain of Tb

108 A high resolution structure of the NTD of TbBILBO1 showed

109 High resolution structures of all the individual BAM sub

110 embly pathways for viruses are inferred from high resolution structures of purified stable intermedia

111 ndent enzyme, we have determined a series of high resolution structures of QueG from Bacillus subtili

112 Despite high resolution structures of the HCN1 channel in the cA

113 Here, we report the high resolution structures of the major pilin subunit, P

114 These x-ray structures are also the first high resolution structures of the Pierisin subgroup of t

115 CRBP1 in a ligand-free form as well as ultra-high resolution structures of this protein bound to eith

116 Based on high resolution structures of TRPV1, we discuss T406 bei

117 Despite efforts, a high-resolution structure of a channel for this family o

118 sue of Cell, Gong et al. (2019) describe the high-resolution structure of a critical component of the

119 We report a high-resolution structure of a designed MPER trimer asse

120 Here, we describe the first high-resolution structure of a full-length PLC-gamma iso

121 A high-resolution structure of a holotoxin embedded in mem

122 We solved the first high-resolution structure of a peptide docking motif (PI

123 al information; currently, there is only one high-resolution structure of a plant sHsp published, tha

124 vious structure of bacterial ELIC (the first high-resolution structure of a pLGIC) as a "locally clos

125 Here, we present a high-resolution structure of a proteorhodopsin from a pe

126 Here we report the first high-resolution structure of a SctK protein family membe

127 Our study reveals the high-resolution structure of a small molecule bound to F

128 We report here the high-resolution structure of a ternary complex of SARS-C

129 -tube crystal structure represents the first high-resolution structure of a virally encoded DNA-trans

130 We present functional characterization and high-resolution structure of an Organic Lake Phycodnavir

131 FliD from Pseudomonas aeruginosa, the first high-resolution structure of any FliD protein from any b

132 Determination of a high-resolution structure of APETx2 combined with scanni

133 The high-resolution structure of authentic infectious prions

134 We have determined and report here the high-resolution structure of B19 virus-like particles (V

135 Homology models based upon the high-resolution structure of bacterial NaV channels pred

136 However, by solving the high-resolution structure of both the wild-type and muta

137 elling activity is hindered by the lack of a high-resolution structure of complexes from this family.

138 Here we solved the high-resolution structure of DISC1 C-terminal tail in co

139 Although the high-resolution structure of EF-G bound to the posttrans

140 r monomeric actin (G-actin) are available, a high-resolution structure of F-actin is still missing, h

141 Here, we present the first high-resolution structure of hGMPK in the apo form, dete

142 The high-resolution structure of holo-PS1 is in sub-A agreem

143 While the high-resolution structure of human PHPT1 (hPHPT1) is ava

144 To date, however, there is no high-resolution structure of iC3b, and some aspects of i

145 cked a library of 600,000 fragments into the high-resolution structure of KDM4A.

146 Here we show the high-resolution structure of melon (Cucumis melo) eIF4E

147 Here, we present the high-resolution structure of netrin-4, which shows uniqu

148 We report a complete high-resolution structure of the 200 kDa alpha-actinin-2

149 due with leucine (p.P72L) that, based on the high-resolution structure of the 28S ribosome, is predic

150 We have determined the high-resolution structure of the BPV capsid assembled fr

151 this issue of Blood, Zhou et al reported the high-resolution structure of the collagen-activated oste

152 Here we present the first high-resolution structure of the complex between an intr

153 We now present a high-resolution structure of the Ctf3c bound to the Cnn1

154 Now, Fernandez-Martinez et al. present a high-resolution structure of the cytoplasmic nuclear por

155 We present the high-resolution structure of the entire AFP particle in

156 We report here a high-resolution structure of the Est3 telomerase subunit

157 The high-resolution structure of the eukaryotic ribosome fro

158 Here, we describe a high-resolution structure of the export apparatus of the

159 A high-resolution structure of the hC3Nb3-C345c complex ex

160 identified a sodium ion binding pocket in a high-resolution structure of the human adenosine A2A rec

161 t sequencing approaches to generate a global high-resolution structure of the IAV genome.

162 infectious scrapie form known as PrP(Sc) The high-resolution structure of the infectious PrP(Sc) stat

163 Here, we determined a high-resolution structure of the LT, an outer membrane l

164 The high-resolution structure of the mammalian ribosome-Sec6

165 According to the high-resolution structure of the mature virion, VI and V

166 Since the first high-resolution structure of the nucleosome was reported

167 Although a high-resolution structure of the protein is still lackin

168 crystal scanning approach, we determine the high-resolution structure of the radiation sensitive mol

169 Here we present the first high-resolution structure of the receptor type found in

170 Here, we report the high-resolution structure of the tail adaptor protein gp

171 Here we report the high-resolution structure of the unbound IKKbeta-binding

172 Understanding the high-resolution structure of the Z-band will help us und

173 cture of the IL-1alpha/aptamer, we provide a high-resolution structure of this critical cytokine and

174 allow for further efforts toward obtaining a high-resolution structure of this important signaling co

175 s TPP1 at telomeres, setting the stage for a high-resolution structure of this interface.

176 Here, we determined the first 1.3 angstrom high-resolution structure of this life-extending protein

177 We reconstructed a high-resolution structure of WHAMM's MT-binding motif (M

178 Here, we report high-resolution structures of 4 states on the pathway of

179 However, despite the availability of high-resolution structures of a mouse 5-HT(3) receptor,

180 made possible the determination of the first high-resolution structures of a peptide and a protein in

181 pening, and activation-gate closure based on high-resolution structures of a single sodium channel pr

182 utiny of the myosin superfamily, the lack of high-resolution structures of actin-bound states has pre

183 While high-resolution structures of all three proteins have be

184 -EM) has emerged as a method for determining high-resolution structures of biological macromolecules

185 Determining high-resolution structures of biological macromolecules

186 Recently, high-resolution structures of both open- and closed-pore

187 Altogether, our database consists of 37 high-resolution structures of caspase-3 variants, and we

188 Here, we present high-resolution structures of catalytic domain 2 from Da

189 Therefore, we used the available high-resolution structures of DEBS domains to model the

190 We present high-resolution structures of Deinococcus radiodurans (D

191 document molecular features consistent with high-resolution structures of engineered soluble and det

192 n isoforms and modeling muscle diseases, but high-resolution structures of fruit fly contractile prot

193 However, high-resolution structures of full-length monomeric M1 a

194 Here, we present two high-resolution structures of Helicobacter pylori XerH w

195 are not known, due, in part, to the lack of high-resolution structures of highly tension-sensitive m

196 High-resolution structures of HIV-1 intasomes are requir

197 program, CATM, predicts ab initio the known high-resolution structures of homodimeric GASright motif

198 We determined high-resolution structures of human GCH1-GFRP complexes

199 Here we present the high-resolution structures of human GPR52 in three state

200 Here we present high-resolution structures of human Sirt2 in complex wit

201 To address this problem, we solved high-resolution structures of human TDG bound to DNA wit

202 Although several high-resolution structures of individual NOS domains hav

203 Making use of high-resolution structures of individual VSG domains, we

204 bly by a momentous increase in the number of high-resolution structures of ion channels, which are pu

205 By determining high-resolution structures of key components of this mot

206 is entering an exciting time where many new high-resolution structures of large complexes and membra

207 However, the lack of high-resolution structures of Lmod nucleators in action

208 yo-electron microscopy (cryo-EM) to generate high-resolution structures of macromolecular complexes h

209 Here, we report high-resolution structures of Magnetospirillum gryphiswa

210 on microscopy is currently poised to produce high-resolution structures of many biological assemblies

211 escribed in budding yeast, and there are now high-resolution structures of many components of the yea

212 Our study provides high-resolution structures of medically relevant FluPol(

213 High-resolution structures of metalloamyloids are needed

214 Here we report the high-resolution structures of MvINS, an Insig homolog fr

215 Here, we determine high-resolution structures of Myo7a and Myo7b C-terminal

216 The absence of high-resolution structures of oligomers formed by alpha-

217 High-resolution structures of oligomers formed by the be

218 hts into receptor-ligand interactions, while high-resolution structures of other members of the penta

219 ivity, is poorly understood, largely because high-resolution structures of PfAct1 filaments were miss

220 We determined high-resolution structures of Phactr1/PP1 bound to the d

221 We have determined high-resolution structures of PhnZ bound to its substrat

222 Despite the existence of several high-resolution structures of pLGICs, their dynamical pr

223 Our high-resolution structures of pro-activin A share featur

224 tal during the past two decades in providing high-resolution structures of protein complexes.

225 We report high-resolution structures of retrovirus-like capsids fo

226 The absence of high-resolution structures of RyR1 has limited our under

227 d groups of clan CD peptidases, there are no high-resolution structures of separases and the details

228 Here we present high-resolution structures of several DHBV capsid-like p

229 al crystallography and the ability to obtain high-resolution structures of small crystals without the

230 yo-EM methodologies can be used to determine high-resolution structures of specimens amassing less th

231 Recent high-resolution structures of TAR-protein complexes have

232 No high-resolution structures of tau filaments are availabl

233 We report the first high-resolution structures of TDG in an enzyme-substrate

234 We generated high-resolution structures of the 1E6 TCR bound to 7 alt

235 A number of high-resolution structures of the 20S proteasome with an

236 on-competent state is unclear due to lack of high-resolution structures of the activated state.

237 in information on ANK folding, we solved two high-resolution structures of the ANK repeat-containing

238 Complementary high-resolution structures of the apo- and Cx-SAM bound

239 Here, I review the extensive ensemble of high-resolution structures of the building blocks of the

240 Here we determine the high-resolution structures of the catalytic domain compr

241 Here we present high-resolution structures of the complete EphA4 ectodom

242 Here, we determined high-resolution structures of the complex of neurexophil

243 Several high-resolution structures of the CTD-CTD dimerization i

244 High-resolution structures of the curved assembly, or in

245 High-resolution structures of the designed proteins CA01

246 Here we report high-resolution structures of the DH and PH domains and

247 Here, the high-resolution structures of the homologous 22-residue

248 Because high-resolution structures of the human LRRK2 kinase dom

249 There are no high-resolution structures of the human transporters ava

250 nisms of which remain unclear due to lack of high-resolution structures of the ligand/co-receptor/rec

251 change remains unresolved and in most cases high-resolution structures of the non-specific complexes

252 High-resolution structures of the protein from Gloeobact

253 ng their predicted folding pathways based on high-resolution structures of the proteins in their nati

254 We also determined high-resolution structures of the trimeric MERS-CoV S ec

255 In this paper, we describe the high-resolution structures of the two main astrovirus ca

256 y Cramer and Ben-Shem and colleagues present high-resolution structures of the yeast SAGA transcripti

257 es, NMR has recently provided the first-ever high-resolution structures of their complexes with unfol

258 -crystallin (ABC) and HSP27; here we present high-resolution structures of their core domains (cABC,

259 With high-resolution structures of these engineered NaK chann

260 High-resolution structures of these proteins while they

261 y of L is largely unknown due to the lack of high-resolution structures of this complex in this viral

262 High-resolution structures of this protein and its assoc

263 This study obtained the first high-resolution structures of three human bocaparvovirus

264 In this issue, Alushin et al. report high-resolution structures of three states of the microt

265 Here we present high-resolution structures of toluene 4-monooxygenase hy

266 Here, we determined high-resolution structures of wild-type Escherichia coli

267 Here we report high-resolution structures of yeast Rev1 with three BP-N

268 The high-resolution structures of yeast RNase for mitochondr

269 Because high-resolution structures of zfV2 and mammalian V1 have

270 High-resolution structures often fail to capture the cou

271 ometer spatial resolution cell that opens up high resolution structure-(photo)activity measurements.

272 ructurally largely uncharacterized and their high-resolution structure prediction is currently hinder

273 High-resolution structures provide new insights into how

274 The high-resolution structure provides detailed insight into

275 Env constructs and ligand complexes used for high-resolution structures recently revealed that they c

276 Owing to their large size (nearly 2.2 MDa), high-resolution structures remained elusive until the ad

277 Furthermore, high-resolution structures representative of nearly ever

278 Enabled by the growing database of high-resolution structures, required deposition of diffr

279 ing protein secondary structure content from high-resolution structures requires definitions and thre

280 These high resolution structures reveal a conserved positively

281 These high resolution structures revealed a hydrophobic groove

282 High-resolution structures revealed that in a two-antibo

283 A high-resolution structure reveals how the ribonucleoprot

284 The high-resolution structure reveals unambiguously the heli

285 High-resolution structures show common patterns of stero

286 The data, together with a survey of high resolution structures, show that the vast majority

287 The high resolution structures showed that removal of the ar

288 However, unlike high-resolution structures stored in PDB, methods for co

289 Furthermore, despite high resolution structures the transported substrate in

290 haracterizing RNA-protein interactions, from high resolution structures to transcriptome-wide profili

291 This work emphasizes the need for a high-resolution structure to guide mutational analysis a

292 rial femtosecond crystallography has allowed high-resolution structures to be determined from micro-m

293 ically realistic atomistic models from known high-resolution structures to determine joint x-ray and

294 mrE, efforts are now underway to determine a high-resolution structure using the S64V mutant identifi

295 isotopic labeling have enabled us to obtain high-resolution structures using fusion proteins, unifor

296 er technique offers the possibility to solve high-resolution structures using submicron crystals.

297 A high-resolution structure was solved for a (full-length

298 its solution behavior and compare it to the high-resolution structure we previously published on ver

299 Prior to achieving a high-resolution structure, we are investigating whether

300 High-resolution structures were determined for four of t