ライフサイエンスコーパス: high-threshold

1 er threshold or the longer-term benefit of a high threshold.

2 one retrieval and replacement of TLP due to high thresholds.

3 nels, characterized by small conductance and high thresholds.

4 campaigns is preserved unless triggers have high thresholds.

5 le regime are usually achieved either with a high threshold (10(2)-10(4) MW cm(-2)) or at cryogenic t

6 g GCMR to the Rasch model from IRT and the 2-High-Threshold (2HT) recognition model.

7 haemically sensitive C fibre afferents had a high threshold (86 +/- 12 mmHg, n = 10) and a larger pea

8 li that are sufficiently intense to activate high-threshold A(delta) and C sensory fibres, which rela

9 6/S1 DRG, of which approximately 75% exhibit high-threshold action potentials that are mediated by TT

10 ve to capsaicin and exhibited TTX-resistant, high-threshold action potentials, whereas a smaller prop

11 NX-482-sensitive transient Ca(2+) current is high-threshold activated and shows moderate steady-state

12 ed by single agent ATRi and CHK1i requires a high threshold activity CDK2.

13 Lamina I NK1R+ neurons were shown to receive high-threshold (Adelta/C fiber) monosynaptic input, wher

14 the TRPV1+/+ littermates while surprisingly high threshold afferent sensitivity was unchanged.

15 NS (33 +/- 7%) and may require activation of high-threshold afferent fibres.

16 nd that ageing is associated with attenuated high-threshold afferent mechanosensitivity in the murine

17 rons in specific spinal laminae that process high threshold afferents and that harbor neurons with sy

18 chanosensory function was more pronounced in high-threshold afferents compared to low-threshold affer

19 e difference from the average gene exceeds a high threshold and codon usage differences from ribosoma

20 bias relative to the average gene exceeds a high threshold and the codon bias relative to ribosomal

21 the deep dorsal horn and were classified as high threshold and wide dynamic range.

22 eral biceps and quadriceps the responses had high thresholds and delayed onset compared with normal s

23 Sodium and potassium have high thresholds and prefer the CF(3) end of the molecule

24 Excitatory neurons show high thresholds and strong adaptation, making them fire

25 to be performed, it may be sufficient to set high thresholds and thereby reduce the complexity of the

26 he modiolar side of the IHC, where ANFs with high-thresholds and low spontaneous rates are normally f

27 c chemiluminescent immunoassay (CLIA) with a high threshold, and immunoglobulin G (IgG)-specific CLIA

28 cal stimuli are classified as low threshold, high threshold, and wide dynamic range neurons.

29 h perception will improve when channels with high thresholds are deactivated.

30 s demonstrated that channels with relatively high thresholds, as measured with the tripolar configura

31 t for fremanezumab's selective inhibition of high-threshold, as a result of a predominant A-delta inp

32 ccine-induced neoantigen-specific T cells by high-threshold assays, 18-month recurrence-free survival

33 A model combining damage to high-threshold auditory nerve fibers with increased resp

34 noise exposure can cause a selective loss of high-threshold auditory nerve fibers without affecting a

35 elevations can occur when there is damage to high-threshold auditory nerve fibre synapses with cochle

36 The most vulnerable medium- and high-threshold-auditory nerve fibres innervate various c

37 that typifies plague is a consequence of the high threshold bacteremia level that must be attained to

38 izing RTK signaling is to erect and maintain high threshold barriers that prevent inappropriate respo

39 ited by thalamocortical neurons that exhibit high-threshold bursts.

40 al dura, and found a selective inhibition of high-threshold but not wide-dynamic range class of neuro

41 pheral inflammation induces 1-2 Hz firing in high-threshold C fibers.

42 reflect the large population of unmyelinated high-threshold C fibre afferents that innervate the urin

43 ith the incidence of spontaneous activity in high-threshold C-fiber afferents.

44 cate that this oscillation correlates with a high threshold Ca(2+) current in the dendrites.

45 ich is capable of the production of isolated high threshold Ca(2+) spikes in distal branch segments,

46 An aging-related increase was found in high-threshold Ca and barium (Ba) currents, particularly

47 pected because it also reduced the composite high-threshold Ca channel current recorded in these cell

48 It similarly reduced the high-threshold Ca channel current that remains after a b

49 It included N-type Ca channels as well as high-threshold Ca channels that displayed the pharmacolo

50 agonist blocks the potentiation by CXCL12 of high-threshold Ca(2+) channels in rat neurons.

51 reas the apamin-sensitive channels relate to high threshold Ca2+ channels.

52 rences in the proportion of low-threshold to high-threshold Ca2+ channels were observed in small and

53 zation of this current was consistent with a high-threshold Ca2+ current.

54 High-threshold Ca2+ currents were also suppressed by (1S

55 The high-threshold calcium channel (gCa) and C-type potassiu

56 a-CTx-MVIIC blocked approximately 50% of the high-threshold calcium channel current; one component (a

57 critically evaluated for antagonism of three high-threshold calcium channel subtypes in rat neurons t

58 icologically relevant lead concentrations on high-threshold calcium currents in chronically exposed m

59 cologically relevant lead concentrations and high-threshold calcium currents in mammalian cells.

60 or human embryonic kidney 293 cells produced high-threshold calcium currents that were blocked by ome

61 prevent the activation and sensitization of high-threshold (central) trigeminovascular neurons by co

62 macological compound that modulates Kv3.1, a high-threshold channel expressed in fast-spiking neurons

63 To select high-threshold channels for deactivation, subjects' thre

64 ype, L-type, and at least two other types of high-threshold channels.

65 effects of XE991 and camphor are largest in high-threshold cold nociceptors.

66 ponded mainly to those of canonical low- and high-threshold cold thermoreceptor neurons.

67 ynia is linked to a reduction of IKD in both high-threshold cold thermoreceptors and nociceptors expr

68 lation not only enhances cold sensitivity of high-threshold cold thermoreceptors signaling cold disco

69 hange occurred earlier in low-threshold than high-threshold cold thermosensors.

70 Kv3.1 gene in mice results in the loss of a high-threshold component of potassium current and failur

71 atients randomized to SLK at week 24 for the high-threshold composite endpoints of ACR70 + PASI 100 (

72 Strictly using high-threshold criteria for HRA referral would have led

73 n our current low-threshold criteria, and if high-threshold criteria were used for HRA referral.

74 o a functional downregulation of IKD in both high-threshold CSNs and in a subpopulation of polymodal

75 IKD density was reduced in high-threshold CSNs from CCI mice compared with sham ani

76 Three components of high-threshold current were distinguished on the basis o

77 onclustered channels are responsible for the high threshold delayed rectifier K(+) current typical of

78 Given the high thresholds demonstrated by LDPC codes, our estimate

79 .6%; anxiety: 36.5%; (hypo)mania: 52.1%) and high thresholds (depression: 9.4%; anxiety: 6.1%; (hypo)

80 High-threshold dorsal root ganglion (HT DRG) neurons fir

81 drotoxin (DTX)-sensitive current (ILT) and a high-threshold DTX-insensitive current (IHT).

82 uracy appears to be inadequate in tests with high thresholds (ELISA; IgG-specific CLIA), combination

83 red spatial response is a spatially-limited, high-threshold expression pattern.

84 the recruitment, but not the firing rate, of high-threshold fast-like motoneurons, with limited influ

85 iated with the higher expression in RAPNs of high threshold, fast-activating voltage-gated Kv3 channe

86 The cac channels contribute to low- and high-threshold, fast- and slow-inactivating types of Ca2

87 Single-fiber analysis showed that high-threshold fibers were particularly affected by alph

88 ergic neurons also had convergent input from high-threshold fibers, suggesting that this novel subcla

89 individual afferents into low-threshold and high-threshold fibres.

90 fibres (2) wide dynamic range fibres and (3) high-threshold fibres.

91 V vaccine development has been hampered by a high threshold for acceptable adverse events.

92 dicate that Kv3.1 channels have an unusually high threshold for activation.

93 n response to stimulatory inputs, imposing a high threshold for changing behaviours.

94 Behavioral screens using a high threshold for detection have generally had limited

95 ty of dopaminergic neurons may explain their high threshold for firing and their low discharge rate.

96 e for the low ligand stability and suggest a high threshold for gammadelta T cell activation.

97 sis algorithm with two tunable parameters: a high threshold for identifying vessel pixels and a low t

98 propose that in the L2 stage, lin-14 sets a high threshold for LIN-12 activation to help prevent pre

99 a-DTX)] played a prominent role in setting a high threshold for somatic calcium spikes, thus restrict

100 The relatively high threshold for spontaneous seizures indicates that s

101 This raises a high threshold for success in future intervention protoc

102 suggest that DNA-PK is involved in setting a high threshold for the ATR-Chk1-mediated S-phase checkpo

103 erian Shakers and channels with an unusually high threshold for voltage activation.

104 These lineages have high thresholds for phylogenetic distance and clade size

105 -standing and unproven fundamental idea that high thresholds for plasticity in the cortex protect pre

106 rrow inclusion criteria focused only on MDD, high thresholds for quality, potential publication bias,

107 tunately, inappropriate screening practices, high thresholds for referral, misplaced concerns about c

108 High-threshold GABAergic inputs, in contrast, cause nonm

109 of morbidity amongst the elderly population High-threshold gastrointestinal sensory nerves play a ke

110 We suggest that some of these "high-threshold" genes dominantly suppress the activity o

111 rates of serious adverse events (25% in the high-threshold group and 22% in the low-threshold group;

112 red in 26% of the infants (85 of 324) in the high-threshold group and in 19% (61 of 329) in the low-t

113 t thresholds of 50,000 per cubic millimeter (high-threshold group) or 25,000 per cubic millimeter (lo

114 In the high-threshold group, 90% of the infants (296 of 328 inf

115 between severe/non-severe BE reactors or low/high threshold groups.

116 R thresholds are used for decision-making: a high threshold (>/=90 ml/min per 1.73 m(2)) to accept an

117 GD, whereas 42/57 (74%) of these neurons had high-threshold (> or =0.4 ml) responses to DD.

118 king it a candidate receptor for transducing high-threshold heat responses in this class of cells.

119 Consistent with CL-II being critical for high-threshold Hh target gene expression, its phosphoryl

120 normal cytology) if availability is high and high-threshold (high-grade squamous intraepithelial lesi

121 CSD-induced activation and sensitization of high threshold (HT) and wide dynamic range (WDR) central

122 were made from wide dynamic range (WDR) and high threshold (HT) dorsal horn neurons in mice with tum

123 Single-unit analysis revealed that both high threshold (HT) fibres (> 15 mmHg; known to be assoc

124 Abs) prevent activation and sensitization of high-threshold (HT) but not wide-dynamic range trigemino

125 in both sexes, fremanezumab inhibited naive high-threshold (HT) neurons, but not wide-dynamic range

126 STT cells in the superficial dorsal horn and high-threshold (HT) STT cells in superficial or deep lay

127 or higher dose of peanut were classified as high-threshold (HT), those who reacted to lower doses we

128 ted two different types of action potential: high-threshold humped spikes in small-sized neurones and

129 neurones which were small in size exhibited high-threshold humped spikes mediated by tetrodotoxin (T

130 Selective organic antagonists of high-threshold (HVA) Ca2+ channels, nimodipine, omega-Co

131 rison, we simulated synaptopathy by removing high threshold IHC-SGN synapses and found that the ampli

132 ion of all three databases at the respective high thresholds improved identification sensitivity to 3

133 When IK(IR) begins to decrease, a high-threshold inactivating Ca2+ current and a slowly ac

134 ion action potentials that are mediated by a high-threshold, inactivating Ca2+ current.

135 and synaptic terminal, contrasting with the high threshold K+ channel subunit Kv3.1 which is located

136 By blocking high-threshold K(+) conductances in motor neurons within

137 ata demonstrate that clusters do not contain high threshold Kv2.1 channels whose voltage sensitivity

138 ape and composition of low-threshold Kv1 and high-threshold Kv3 potassium currents but display marked

139 Many such neurons express "high threshold" Kv3-family channels that are required fo

140 lting temperature and P is pressure, above a high threshold laser fluence; while the slower thermal p

141 Current optical transmitters consisting of high-threshold lasers plus external modulators consume f

142 xhibit a constant probability of attaining a high threshold level of Spo0A P due to fluctuations in t

143 ter bacterial numbers in vivo have reached a high threshold level, commonly called the lethal load.

144 ed with, and preceded by, Spo0A P reaching a high threshold level; (iii) activation of Spo0A takes pl

145 tation, we found that sporulation required a high (threshold) level of Spo0A and that many genes in t

146 control rats were capsaicin sensitive, with high-threshold long-duration action potentials that were

147 gets of the low- and mid-thresholds with the high-threshold (maximum sample size, 1500 with respect t

148 aw withdrawal responses to low threshold and high threshold mechanical stimuli compared to pre-operat

149 nd lowered the threshold of response for the high threshold mechanical stimuli in a dose-dependent ma

150 Here, we show that Cirl is also expressed in high-threshold mechanical nociceptors where it adjusts n

151 ry neurons that are selectively activated by high-threshold mechanical stimulation (HTMRs).

152 Positive C-fibre high threshold mechanoreceptive (HTM) units had receptiv

153 nd thermal stimuli as nociceptive (including high-threshold mechanoreceptive (HTM) units), and non-no

154 ptor (LTM) units, A-mechanoheat (AMH) units, high threshold mechanoreceptor (HTM) units, and C-mechan

155 in C-fibre nociceptors was apparent both in high threshold mechanoreceptor and polymodal nociceptors

156 rast, none of twenty superficial cutaneous A high threshold mechanoreceptor units or the thirty-five

157 receive convergent inputs from both low- and high-threshold mechanoreceptor subtypes and exhibit one

158 n shown to deplete the population of A-delta high threshold mechanoreceptors and to reduce neurogenic

159 reduced von Frey thresholds of C- and A-slow-high-threshold mechanoreceptors (HTMR) fibers but had no

160 hether the same might be true for myelinated high-threshold mechanoreceptors (HTMRs).

161 few small nociceptor neurons (which include high-threshold mechanoreceptors).

162 In contrast, citric acid activated only 8/17 high threshold mechanosensitive jugular Adelta fibres.

163 In the gut, high-threshold mechanosensitive fibres also express Nav1

164 Sensations of touch, proprioception, and high-threshold mechanosensitive nociception, as well as

165 High-threshold mechanosensory afferent fibres and small-

166 arations, octreotide inhibited both low- and high-threshold mechanosensory responses, whereas in the

167 ns, which were correlated with TTX-sensitive high-threshold membrane potential oscillations mediated

168 susceptibility to excitability changes since high-threshold MNs innervating fast fatigable muscle fib

169 s a differential adjustment between low- and high-threshold motor units during painful conditions.

170 An increase in excitatory drive to high-threshold motor units is likely required to compens

171 which was greater for low- than medium- and high-threshold motor units.

172 In contrast, blockade of high-threshold N-type calcium channels increased the fir

173 The activation of high-threshold (N-type and L-type) voltage-gated Ca(2+)

174 I neurons in control slices were elicited by high-threshold nerve stimulation, whereas the majority o

175 ascular Adelta-, C-, wide-dynamic range, and high-threshold neurons in male and female rats.

176 s a result of a predominant A-delta input to high-threshold neurons, but not wide dynamic-range dorsa

177 of the Adelta-, C-, wide-dynamic range, and high-threshold neurons, respectively.

178 ctivation of a normally silent population of high-threshold neurons.

179 tors may be restricted to synapses formed by high-threshold nociceptive (pain-sensing) and thermorece

180 These neurons include high-threshold nociceptors that are involved in transduc

181 effects on low-threshold mechanosensors and high-threshold nociceptors.

182 ection of noxious heat in a subpopulation of high-threshold nociceptors.

183 en expressed heterologously, gives rise to a high-threshold noninactivating potassium current.

184 Kv3.1 mRNA levels and in the amplitude of a high-threshold, noninactivating current before the onset

185 other delayed rectifier channels by its very high threshold of activation and lack of use-dependent i

186 um channel Kv3.1, a delayed rectifier with a high threshold of activation, is expressed in the time c

187 The lung must maintain a high threshold of immune 'ignorance' to innocuous antige

188 mary, our findings suggest that a relatively high threshold of similarity is required to establish ef

189 rmal tissues of young mice but is induced by high thresholds of aberrant hyperproliferative signals,

190 n and DNA damage that are triggered when the high thresholds of intracellular Ca2+ required for cell

191 Despite high-threshold operation parameters of the fs system, co

192 threshold, relay cells produce a fast ragged high threshold oscillation in somatic voltage.

193 ible for separating low threshold input from high threshold output neurons of lamina I.

194 (IR) is absent when only a slowly activating high-threshold outward K+ current is present, these acti

195 asers reported to date exhibit impractically high thresholds owing to their unfavourable bandstructur

196 nts included 23 children with no PA, 74 with high-threshold PA (reacting to >= 443 mg cumulative pean

197 tomes as 73 children aged 4 to 14 years with high-threshold peanut allergy received OIT or avoided pe

198 ng rats demonstrated the loss of low but not high threshold penile inputs to medullary reticular form

199 ocess initiated by activation of specialised high-threshold peripheral sensory neurons.

200 The expression patterns for two high-threshold potassium channels, Kv3.1 and Kv3.3, that

201 We propose that, after the decay of high-threshold potassium currents, the tonic cation curr

202 asy-to-fabricate nanolasers, but suffer from high threshold powers.

203 These receptors also contribute to high-threshold primary afferent drive onto NK1R+ neurons

204 derlie inflammation-induced sensitization of high-threshold primary afferent neurons, including the m

205 igated by decision curve analysis showed, at high threshold probabilities (0.8, aiming to avoid false

206 Low versus high threshold reactivity-groups had differential freque

207 oral task, children (7- to 11-year-olds) had high thresholds, regardless of language status, but teen

208 ndows and stratified into low, moderate, and high thresholds, respectively.

209 This induces a suite of high-threshold response genes in the underlying mesenchy

210 ral neurogenic ectoderm demands a relatively high-threshold response to dl.

211 esponses to DD (<or=0.2 ml) and 26 (22%) had high-threshold responses to DD (>or=0.4 ml).

212 nses preferentially and failed to affect the high-threshold responses.

213 proposed thresholds were more sensitive than high thresholds (sensitivities: distribution volume rati

214 old sensory fibres, while these receptors on high threshold sensory fibres mediate pain.

215 ing neurons received direct projections from high-threshold sensory afferents but transmitted nocicep

216 al spinal cord, where they are innervated by high-threshold sensory afferents.

217 of intense or noxious stimuli by specialized high-threshold sensory neurons (nociceptors), a transfer

218 We also identify a pair of high-threshold sensory neurons that encode variability i

219 classes of primary afferents were found: 70 high-threshold serosal afferents, four low-threshold mus

220 sustained unresponsiveness (SU) or sustained high threshold (SHT) have different baseline sequential

221 Blockade or ablation of high-threshold, small-diameter unmyelinated group C nerv

222 trated a mixture of inputs from both low and high threshold sources.

223 ble Pittsburgh compound-B signal, as well as high thresholds (standard uptake value ratiohigh = 1.40,

224 The mature action potential is mediated by a high-threshold sustained Ca2+ current.

225 rointestinal system is innervated by low and high threshold sympathetic C fibre afferents, the latter

226 e of the BMP-activity gradient and increased high threshold target gene expression in the early embry

227 Surprisingly, the high-threshold target gene snail only requires Dorsal in

228 wing discs, overexpression of Ihog represses high-threshold targets, while extending the range of low

229 Onset cells have a unique high-threshold tetraethylammonium-sensitive K(+) current

230 neurones which were small in size expressed high-threshold tetrodotoxin (TTX)-resistant Na+ channels

231 includes a model for a specialized class of high-threshold thalamocortical cells (HTC cells), which

232 PTEN), potentially setting Akt activity at a high threshold that is unresponsive to EGFR inhibition a

233 were found to be unrelated, as predicted by high-threshold theories.

234 tential V2 (TRPV2) has been proposed to be a high-threshold thermosensor.

235 Firing threshold decreases among high-threshold TMNs and increases in a subpopulation of

236 Neurons with high thresholds to injected currents contact hair cells

237 lls at synaptic positions where neurons with high thresholds to sound-intensity are found in vivo.

238 Such a high threshold together with local parity-check measurem

239 This high-threshold transient K+ current was abolished by ext

240 Adelta) and central (wide dynamic range and high-threshold) trigeminovascular neurons in intact and

241 ifting the expression of Na+ channels from a high-threshold TTX-resistant type to a low-threshold TTX

242 Enhancements above the generally high threshold value of 2.5 have important implications

243 or each individual revealing both abnormally high threshold values (P = 0.0053) and shallow psychomet

244 45% of individual variances in the low- and high-threshold variants of three psychoacoustic tasks as

245 uclear export of Dorsal leads to loss of the high-threshold, ventrally expressed target gene snail (s

246 viously reported that the current density of high threshold voltage-activated (HVA) calcium (Ca(2+))

247 substantial decrease in the amplitude of the high-threshold voltage-activated (HVA) calcium current.

248 K current is activated by Ca2+ entry through high-threshold voltage-activated Ca2+ channels (L- and N

249 d K+ currents and their Ca2+ sources through high-threshold voltage-activated Ca2+ channels were stud

250 ve to that of Kv3.1b subunits, which mediate high-threshold voltage-activated currents.

251 xhibited significantly decreased whole cell, high-threshold voltage-dependent calcium currents, with

252 Ca(2+) influx through the dendritic high-threshold voltage-gated Ca(2+) channels activates C

253 + and was inhibited 65 +/- 3% by blockade of high-threshold voltage-gated Ca2+ channels with omega-gr

254 , chloride efflux through CaCC, coupled with high-threshold voltage-gated calcium channels, sustains

255 High-threshold voltage-gated calcium currents were recor

256 three different pathways for calcium influx: high-threshold voltage-sensitive calcium channels, NMDA

257 also shown for five of seven parameters for high-threshold vs. low-threshold MNs, and three of seven

258 quire determining whether the other types of high-threshold VSCCs (e.g., N, P/Q, and R) also exhibit

259 In both spinal segments, an area of high threshold was found in the middle of the dorsolater

260 cellular Wg, producing ectopic activation of high threshold Wg targets but reducing the expression of