ライフサイエンスコーパス: higher eukaryote

1 s acquired additional functional features in higher eukaryotes).

2 100- to 1,000-kbp-sized domains observed in higher eukaryotes).

3 egulatory axis in controlling development in higher eukaryotes.

4 died in bacteria and yeast, less is known in higher eukaryotes.

5 ay play a role in lysosomal acidification in higher eukaryotes.

6 nisms targeting genes and repeat elements in higher eukaryotes.

7 genomic fragments for genetic engineering of higher eukaryotes.

8 r poses a significant information problem in higher eukaryotes.

9 Bub3 activity and chromosome congression in higher eukaryotes.

10 ike the unfolded protein response pathway in higher eukaryotes.

11 omic diversity, which is likely unique among higher eukaryotes.

12 ation of genome stability by nuclear RNAi in higher eukaryotes.

13 reas RNMTL1 appears to have evolved later in higher eukaryotes.

14 are subject to restricted nuclear export in higher eukaryotes.

15 important means of diversifying function in higher eukaryotes.

16 for homologues of Rgf1p in budding yeast and higher eukaryotes.

17 hannel synthesis being controlled by Mg2+ in higher eukaryotes.

18 ted gene families that are commonly found in higher eukaryotes.

19 posons and other repetitive elements in many higher eukaryotes.

20 fication present in the messenger RNA of all higher eukaryotes.

21 of monomeric actin (G-actin) within cells of higher eukaryotes.

22 nticodon 'wobble' position in both yeast and higher eukaryotes.

23 tekeeper role in the proteostasis network of higher eukaryotes.

24 res many conserved biological functions with higher eukaryotes.

25 replication of G-quadruplex DNA (G4 DNA) in higher eukaryotes.

26 by a complex, replication-coupled pathway in higher eukaryotes.

27 basis and regulation of NAD(+) metabolism in higher eukaryotes.

28 ) subunits present in both budding yeast and higher eukaryotes.

29 functional diversification between lower and higher eukaryotes.

30 ng nucleosomes, much like heterochromatin in higher eukaryotes.

31 ination is not well defined, particularly in higher eukaryotes.

32 -tail signaling pathway is poorly defined in higher eukaryotes.

33 e versatile regulators of gene expression in higher eukaryotes.

34 an essential strategy for gene silencing in higher eukaryotes.

35 prevent ethanol-associated carcinogenesis in higher eukaryotes.

36 fects of oxidative stress on mitochondria in higher eukaryotes.

37 d for formation of extracellular matrices in higher eukaryotes.

38 ransposons and other repeat elements in many higher eukaryotes.

39 s underlying the developmental ontologies of higher eukaryotes.

40 rnal modification of messenger RNA (mRNA) in higher eukaryotes.

41 ll migration and neuronal differentiation in higher eukaryotes.

42 So far, no CaM gene deletion was reported in higher eukaryotes.

43 s, morphogenesis, and the development of all higher eukaryotes.

44 oxidase site is identified in ferritins from higher eukaryotes.

45 s highly conserved from unicellular yeast to higher eukaryotes.

46 tion as a widespread regulatory mechanism in higher eukaryotes.

47 echanisms controlling Cdc14B phosphatases in higher eukaryotes.

48 described, process of ribosome biogenesis in higher eukaryotes.

49 dreds of nuclear and cytoplasmic proteins in higher eukaryotes.

50 lamina is a key step during open mitosis in higher eukaryotes.

51 he regulation of transcription initiation in higher eukaryotes.

52 oper selection of DNA replication origins in higher eukaryotes.

53 rs and their target genes are commonplace in higher eukaryotes.

54 lymerase 1 (PARP1), a chromatin regulator in higher eukaryotes.

55 important genes in the genomes of almost all higher eukaryotes.

56 ary development of redundant NLSs in NXF1 of higher eukaryotes.

57 se proteins are used for "genome editing" in higher eukaryotes.

58 ssential roles in the chromatin structure of higher eukaryotes.

59 d is a major source for protein diversity in higher eukaryotes.

60 that are generally common to those found in higher eukaryotes.

61 chaperone, called Scm3 in yeast and HJURP in higher eukaryotes.

62 environments, including during infection of higher eukaryotes.

63 al fraction of NAC is non-ribosomal bound in higher eukaryotes.

64 nscriptional repression and silencing in all higher eukaryotes.

65 ations impact the function of H1 variants in higher eukaryotes.

66 ionally analogous to the mucus secretions of higher eukaryotes.

67 n clathrin-mediated endocytosis in yeast and higher eukaryotes.

68 T corresponds to the mediator head module of higher eukaryotes.

69 are critical regions for gene regulation in higher eukaryotes.

70 de a mechanism for lethality of Apex loss in higher eukaryotes.

71 protein processing are poorly understood in higher eukaryotes.

72 a C-terminal domain (CTD) that is unique to higher eukaryotes.

73 tes a pre-rRNA processing event specific for higher eukaryotes.

74 ments that are sequestered in the nucleus in higher eukaryotes.

75 er networks, such as functional networks for higher eukaryotes.

76 synthesized acid hydrolases to lysosomes in higher eukaryotes.

77 is a predominant form of gene regulation in higher eukaryotes.

78 lex may also function in RNA surveillance in higher eukaryotes.

79 with the preferred methylation consensus of higher eukaryotes.

80 clear how recovery and fork restart occur in higher eukaryotes.

81 ents (TEs) are major sources of new exons in higher eukaryotes.

82 identify TFs and cis regulatory elements in higher eukaryotes.

83 nderstanding of NE structure and function in higher eukaryotes.

84 either of these types of microorganisms with higher eukaryotes.

85 erved organelles present in basal as well as higher eukaryotes.

86 n unicellular organisms, but is mitigated in higher eukaryotes.

87 rototype for understanding related events in higher eukaryotes.

88 logue of the AMP-activated protein kinase in higher eukaryotes.

89 n, and also influences gene transcription in higher eukaryotes.

90 tanding the distinctions of origin firing in higher eukaryotes.

91 eby crucially regulate gene transcription in higher eukaryotes.

92 n of cargo and phagophores are integrated in higher eukaryotes.

93 ed polymer are scarcely known, especially in higher eukaryotes.

94 D functions through a conserved mechanism in higher eukaryotes.

95 choring and function extends beyond yeast to higher eukaryotes.

96 cription machinery relevant from bacteria to higher eukaryotes.

97 ve roles in multiple processes that occur in higher eukaryotes.

98 or proteome expansion and gene regulation in higher eukaryotes.

99 G-protein-based symmetry-breaking systems of higher eukaryotes.

100 and as the first independent I9 inhibitor in higher eukaryotes.

101 and non-randomly organized in the nucleus of higher eukaryotes.

102 tiotemporal and functional specialization in higher eukaryotes.

103 of lysosomes where it is typically found in higher eukaryotes.

104 arches in transcriptional gene regulation in higher eukaryotes.

105 80CTR and DNA-PKcs only occur in a subset of higher eukaryotes.

106 tical roles in maintaining sterol balance in higher eukaryotes.

107 MN), a multifunctional protein essential for higher eukaryotes.

108 decapping activities and mRNA metabolism in higher eukaryotes.

109 n certain yeast strains, but barely found in higher eukaryotes.

110 omplexes also encounter replication forks in higher eukaryotes.

111 ses that shape the complex transcriptomes of higher eukaryotes.

112 complexes is largely unknown, especially in higher eukaryotes.

113 ernative MPC subunits have been described in higher eukaryotes.

114 derstood how CDC6 activity is constrained in higher eukaryotes.

115 mechanisms at the inner nuclear membrane of higher eukaryotes.

116 % of all alternative splicing (AS) events in higher eukaryotes.

117 ey structural components of the chromatin of higher eukaryotes.

118 ay critical roles in chromatin compaction in higher eukaryotes.

119 as a cell-specific mRNA labeling reagent in higher eukaryotes.

120 restoring small linear chromosome numbers in higher eukaryotes.

121 kely relevant for development and disease in higher eukaryotes.

122 nserved during evolution from prokaryotes to higher eukaryotes, a detailed evolutionary assessment of

123 In higher eukaryotes, a variety of proteins are post-transl

124 homologues initiate mismatch repair and, in higher eukaryotes, act as DNA damage sensors that can tr

125 onribosomal peptide synthetase (NRPS) from a higher eukaryote and contains a C-terminal sequence that

126 ier PRMT7 is the only Type III PRMT found in higher eukaryotes and a restricted number of unicellular

127 highlighting distinctions between yeast and higher eukaryotes and a role for eIF3 in elongation.

128 to post-replicative DNA repair in yeast and higher eukaryotes and accumulates at sites of laser-indu

129 hat are conserved in homologous complexes in higher eukaryotes and are reported to interact with modi

130 s notion that the enzyme is non-essential in higher eukaryotes and cautions against targeting the enz

131 es applicable to numerous species, including higher eukaryotes and humans.

132 tif found in critical regulatory proteins of higher eukaryotes and in certain species of bacteria.

133 s a modified base present in the mRNA of all higher eukaryotes and in Saccharomyces cerevisiae, where

134 r tryptophan restriction extends lifespan in higher eukaryotes and increased proline or tryptophan le

135 hanges with target loci is unprecedented for higher eukaryotes and indicates that most repair events

136 st-translational modification that occurs in higher eukaryotes and is involved in cell-cell communica

137 Cellular messenger RNA (mRNA) of higher eukaryotes and many viral RNAs are methylated at

138 he mechanism of ATG3 recruitment by ATG12 in higher eukaryotes and place ATG12 among the members of s

139 ryotes and a newly established member of the higher eukaryotes and prokaryotes nucleotide-binding (HE

140 the other RNase activity provided by the two Higher Eukaryotes and Prokaryotes Nucleotide-binding (HE

141 d by catalytic residues in the two conserved Higher Eukaryotes and Prokaryotes Nucleotide-binding (HE

142 h degrade RNA non-specifically using a HEPN (Higher Eukaryotes and Prokaryotes, Nucleotide binding) a

143 cytoplasmic filaments of the NPC specific to higher eukaryotes and provides a multitude of binding si

144 g controls a myriad of cellular processes in higher eukaryotes and similar signaling pathways are evo

145 nservation of NatA biochemical properties in higher eukaryotes and uncover specific and essential fun

146 ional chromatin states between the algae and higher eukaryotes and uncovered regulatory components at

147 nt DNA double-strand break repair pathway in higher eukaryotes) and is stimulated by XLF.

148 plex subassembly Okp1/Ame1 (CENP-Q/CENP-U in higher eukaryotes), and that this interaction is inhibit

149 PTS2 processing upon import is conserved in higher eukaryotes, and in watermelon the glyoxysomal pro

150 Lalpha complexes remain mostly unexplored in higher eukaryotes, and models are predominately based on

151 roles in organization of complex genomes of higher eukaryotes, and their coordinated actions appear

152 Centromeres in most higher eukaryotes are composed of long arrays of satelli

153 Centromeres of higher eukaryotes are defined by the epigenetic inherita

154 Centromeres of higher eukaryotes are epigenetically defined by centrome

155 Centromeres of higher eukaryotes are epigenetically marked by the centr

156 ance systems that respond to such defects in higher eukaryotes are not clear.

157 wall and their roles in neurotransmission in higher eukaryotes are well-established.

158 that the Trf4p/Air2p complex is conserved in higher eukaryotes as well as in yeast and that the TRAMP

159 t are likely to apply to related proteins in higher eukaryotes as well.

160 dictate asymmetric cell division in diploid, higher eukaryotes as well.

161 e them are also used in antiviral defense in higher eukaryotes, as they are in plants and lower eukar

162 le to assume that this mechanism operates in higher eukaryotes, as well.

163 nly a few centromeres have been sequenced in higher eukaryotes because of their repetitive nature, th

164 The strap is conserved in higher eukaryotes but absent from yeast and prokaryotes

165 This protein has homologs not only in higher eukaryotes but also in bacteria, fungi, and plant

166 interactions are physiologically relevant in higher eukaryotes but also indicate that these interacti

167 owth of cells ranging from microorganisms to higher eukaryotes, but its molecular targets are largely

168 totic cyclin types, cyclin A and B, exist in higher eukaryotes, but their specialised functions in mi

169 ndoplasmic reticulum and nuclear envelope of higher eukaryotes, but what it does and how changes caus

170 thin pericentromeric heterochromatin in most higher eukaryotes, but, interestingly, it can show euchr

171 Such conjecture has been supported in higher eukaryotes by direct studies of several individua

172 Higher eukaryotes can thus control low rates of near irr

173 esidues on cytosolic and nuclear proteins of higher eukaryotes catalyzed by O-GlcNAc transferase (OGT

174 on or reduction of FIT proteins in yeast and higher eukaryotes causes LDs to remain in the ER membran

175 A occurs and what its potential roles are in higher-eukaryote cells remain unknown.

176 In higher eukaryotes, centromeres are typically composed of

177 R)-plasma membrane (PM) contacts in cells of higher eukaryotes concerns proteins implicated in the re

178 DNA repair by non-homologous end-joining in higher eukaryotes, consists of a catalytic subunit (DNA-

179 spite much progress, it is still unclear why higher eukaryotes contain multiple core histone genes, h

180 Although higher eukaryotes contain multiple TAF variants that spe

181 e find that the C-terminal domain of OS-9 in higher eukaryotes contains "mammalian-specific insets" t

182 udy thus reveals a unique mechanism by which higher eukaryotes deal with the collateral effect of sil

183 nome-wide screen for dosage sensitivity in a higher eukaryote demonstrates the importance of global g

184 rom transit amplifying cells is critical for higher eukaryote development.

185 ve organism to study cytokinesis as it, like higher eukaryotes, divides using a contractile actomyosi

186 ation is relatively limited, particularly in higher eukaryotes, due to technical difficulties stemmin

187 We suggest that "silencing" in higher eukaryotes (e.g., by Polycomb or HP1) follows sim

188 Knockdown of UAP56 [2, 3] and NXF1 [4-7] in higher eukaryotes efficiently blocks mRNA export, wherea

189 Higher eukaryotes encode various Y-family DNA polymerase

190 Higher eukaryotes express repeated copies of three close

191 ies that are conserved from bacteria through higher eukaryotes facilitate assembly of the FeS cofacto

192 uine is a micronutrient that is scavenged by higher eukaryotes from the diet and gut microflora.

193 In higher eukaryotes, growth factors promote anabolic proce

194 5 protons to make each ATP, but until now no higher eukaryote has been examined.

195 nd long-term effect of ionizing radiation on higher eukaryotes has been well documented, we do not ha

196 The extensive alternative splicing in higher eukaryotes has initiated a debate whether alterna

197 Complementary work on autophagy in higher eukaryotes has revealed both the deep conservatio

198 ces cerevisiae Sae2 and its ortholog CtIP in higher eukaryotes have a conserved role in the initial p

199 cerevisiae protein Ddi1 and its homologs in higher eukaryotes have been proposed to serve as shuttli

200 Higher eukaryotes have evolved elegant and redundant pat

201 Many higher eukaryotes have evolved strategies for the matern

202 Higher eukaryotes have two complexes, condensin I and co

203 in bacterial and viral pathogens as well as higher eukaryotes, have evolved to inhibit and fine-tune

204 In higher eukaryotes, heritable gene silencing is associate

205 signaling extends the life span in yeast and higher eukaryotes; however, the mechanisms are not compl

206 In higher eukaryotes, Hsp90 and Hsp70 form a functionally a

207 owever, mechanistic insights into the HSR in higher eukaryotes, in particular in mammals, are limited

208 teria to mediating the action of hormones in higher eukaryotes, including human.

209 cies in craniofacial and limb development in higher eukaryotes, including split hand and foot malform

210 evidence suggests that UPRT homologues from higher-eukaryotes, including Drosophila, are incapable o

211 In higher eukaryotes, increasing evidence suggests, gene ex

212 ) plays a central role in DNA replication in higher eukaryotes, initiating synthesis on both leading

213 The best understood PCD pathway in higher eukaryotes is apoptosis although emerging evidenc

214 Protein fate in higher eukaryotes is controlled by three complexes that

215 The existence of a DPC protease in higher eukaryotes is inferred from data in Xenopus laevi

216 1/RAD50/NBS1 (MRN) complex in end joining in higher eukaryotes is less certain.

217 Our findings suggest that UPRT from all higher eukaryotes is likely enzymatically active in vivo

218 Oxygen sensing via the Cys-Arg/N-end rule in higher eukaryotes is linked through a single mechanism t

219 Mitosis in higher eukaryotes is marked by the sequential assembly o

220 trates that regulation of O-mannosylation in higher eukaryotes is more complex than envisioned, and t

221 aling diversity and subsequent complexity in higher eukaryotes is partially explained by one gene enc

222 Ribosomal protein (RP) expression in higher eukaryotes is regulated translationally through t

223 Elongator in higher eukaryotes is required for normal growth and deve

224 anism in genome defense and RNA silencing in higher eukaryotes is suggested.

225 Alternative splicing (AS), in higher eukaryotes, is one of the mechanisms of post-tran

226 f its catalytic core that is only present in higher eukaryotes, lead to gain-of-function X-linked pro

227 In higher eukaryotes, loss of cytoplasmic ribosomal protein

228 ound in the mitochondria and chloroplasts of higher eukaryotes, mammalian nuclei, and many other bact

229 strates for the alkyltransferase proteins in higher eukaryotes might, by analogy, signal such lesions

230 In higher eukaryotes, mtRNAP requires two transcription fac

231 Higher eukaryotes must adapt a totipotent genome to spec

232 Because postmitotic cells in higher eukaryotes often do not starve, we developed a mo

233 ignaling pathway of bacteria--is found among higher eukaryotes only in plants, where it regulates div

234 Thus, sterols such as cholesterol in higher eukaryotes or ergosterol in fungi may regulate th

235 binds to specific DNA elements; however, in higher eukaryotes, ORC exhibits little sequence specific

236 in which to elucidate consequences of GD for higher eukaryotes, owing to their propensity for chromos

237 position CTD kinases have been identified in higher eukaryotes: P-TEFb and CDK12/CyclinK.

238 Targeting endogenous protein complexes of higher eukaryotes, particularly in large-scale efforts,

239 tissue specification and differentiation in higher eukaryotes, particularly man, remains limited.

240 dentification of i6A37-containing tRNAs in a higher eukaryote, performed using small interfering RNA

241 Compared to higher eukaryotes, Plasmodium parasites have a fundament

242 iscovery of interchromosomal interactions in higher eukaryotes points to a functional interplay betwe

243 The chromosomes of higher eukaryotes possess discrete compartments that are

244 In higher eukaryotes, proteins containing DENN-domains comp

245 In higher eukaryotes, reductions of H3K9me3 and DNA methyla

246 teristic heptad repeats (K7ac)-only found in higher eukaryotes-regulates phosphorylation of serines a

247 that control this PtdIns4P pool in cells of higher eukaryotes remain elusive.

248 nd bacteria, the mechanism of DNA priming in higher eukaryotes remains poorly understood in large par

249 ciently demonstrated, its biological role in higher eukaryotes remains poorly understood.

250 ated reaction; in contrast, its mechanism in higher eukaryotes remains unclear.

251 e possibility that appearance of this PTM in higher eukaryotes represents an evolutionary substitutio

252 In higher eukaryotes, secretory vesicles are transported to

253 verall our data indicate that Neurospora and higher eukaryotes share a common mechanism for the signa

254 sed hypothesis is suggested to apply also to higher eukaryotes, since the key components are conserve

255 SAXS, we also describe the structure of the higher eukaryote specific RPC5 C-terminal extension.

256 e data indicate that NF45 and NF90 are novel higher-eukaryote-specific factors required for the matur

257 r yeast heterohexameric counterparts, but in higher eukaryotes such as Drosophila, MCM-associated DNA

258 Small RNAs are well described in higher eukaryotes such as mammals and plants; however, k

259 Whereas higher eukaryotes such as plants and mammals hardly surv

260 The expansion of the ATG8 family in higher eukaryotes suggests that specific interactions wi

261 through much more diversified mechanisms in higher eukaryotes than previously thought.

262 emonstrate a mechanism for RNR regulation in higher eukaryotes that acts by enhancing allosteric RNR

263 mologous type IA TOP3alpha and TOP3beta from higher eukaryotes that also have multiple 4-Cys zinc rib

264 enabling insertional mutagenesis screens in higher eukaryotes that are not amenable to germline tran

265 s (GPCRs) are important membrane proteins in higher eukaryotes that carry out a vast array of cellula

266 or the mechanistic pathway in ferritins from higher eukaryotes that drive uptake of bivalent cation a

267 During evolution of higher eukaryotes that utilize vitamin B12, the high rea

268 In higher eukaryotes, the APC/C works with the E2 enzyme UB

269 Within the secretory pathway of higher eukaryotes, the core of these glycans is frequent

270 In higher eukaryotes, the endoplasmic reticulum (ER) contai

271 ion of the dynein motor domain from yeast to higher eukaryotes, the extensively studied S. cerevisiae

272 n metabolism differ drastically in fungi and higher eukaryotes, the glutaredoxins are conserved, yet

273 In Saccharomyces cerevisiae and higher eukaryotes, the loading of the replicative helica

274 ng pathways in different hosts.IMPORTANCE In higher eukaryotes, the majority of transcribed RNAs do n

275 Instead, our data show that, like other higher eukaryotes, the MCM complex in plants remains in

276 In higher eukaryotes, the microRNA biogenesis enzyme Dicer

277 In higher eukaryotes, the mitochondrial GTPase Miro binds M

278 In higher eukaryotes, the related actin depolymerizing fact

279 Thus, in higher eukaryotes, there appears to be redundancy betwee

280 Similar to 'enhancer-blocking insulators' in higher eukaryotes, these factors shield the proximal pro

281 In higher eukaryotes, these processes are important for pre

282 ive splicing (AS) of pre-mRNA is utilized by higher eukaryotes to achieve increased transcriptome and

283 s a powerful tool but has been restricted in higher eukaryotes to artificial cell lines and reporter

284 Alternative splicing enables higher eukaryotes to increase their repertoire of protei

285 In higher eukaryotes, transfer RNAs (tRNAs) with the same a

286 In higher eukaryotes, up to 70% of genes have high levels o

287 It is well established that higher eukaryotes use alternative splicing to increase p

288 ria in their microbial consortia, similar to higher eukaryotes, using unique secondary metabolites th

289 Higher eukaryotes utilize Spt4-Spt5 (DSIF) to regulate p

290 In higher eukaryotes we find a strong enhancement of Z-form

291 y the physiological significance of Cdc20 in higher eukaryotes, we generated hypomorphic mice that ex

292 an integral component of the CSN complex in higher eukaryotes, where it is essential for life.

293 starvation, this pathway is also present in higher eukaryotes, where it is triggered by stress signa

294 This observation contrasts with higher eukaryotes, where RPS23 is monohydroxylated; the

295 se modifications are signatures of "self" in higher eukaryotes, whereas unmodified cap0-RNA is recogn

296 is a crucial factor for the survival of most higher eukaryotes which depend on class II photolyases t

297 g greater degrees of chromatin compaction in higher eukaryotes, which have evolved several mechanisms

298 recursor of the transcription factor Nrf1 in higher eukaryotes, which results in the up-regulation of

299 2A.Z-containing pericentric chromatin, as in higher eukaryotes with regional centromeres, is importan

300 mtFAS is poorly characterized, especially in higher eukaryotes, with the major product(s), metabolic