ライフサイエンスコーパス: higher order structure

1 that concerted change is partially driven by higher order structure.

2 ion in both their primary sequence and their higher order structure.

3 , thus providing a better overall picture of higher order structure.

4 sociation (UVPD) for the characterization of higher order structure.

5 the organization of cellulose fibers into a higher-order structure.

6 ted region (UTR) hairpin that disrupts local higher-order structure.

7 tection at the SPA region, consistent with a higher-order structure.

8 hange reaction without affecting the protein higher-order structure.

9 i interactions are important in formation of higher-order structure.

10 ent with formation of a unique, more compact higher-order structure.

11 laments, most likely due to a twist in their higher-order structure.

12 mplex than that of F-actin, reflecting their higher-order structure.

13 by linking PRC1 to formation of a repressive higher-order structure.

14 iversify their molecular fate while adopting higher-order structure.

15 a well-known technique for studying protein higher-order structure.

16 to a foreign ectodomain, suggesting a common higher-order structure.

17 he polymerization of the nuclear lamins into higher order structures.

18 inked trimers that further oligomerized into higher order structures.

19 guide the arrangement of the acene core into higher order structures.

20 hibited the formation of calnexin dimers and higher order structures.

21 nsin is linked to its ability to form stable higher order structures.

22 ture epitopes displayed on E-homo-dimers and higher order structures.

23 anization of individual building blocks into higher order structures.

24 complexes that can assemble in filaments and higher-order structures.

25 modes could fold chromatin to form distinct higher-order structures.

26 t its ability to bundle actin filaments into higher-order structures.

27 tions through the formation of filaments and higher-order structures.

28 alpha-keratin was influenced by primary and higher-order structures.

29 motility, suggesting a novel role for these higher-order structures.

30 ities, but they can also form bonds to yield higher-order structures.

31 ed epitope peptides enabled investigation of higher-order structures.

32 ection and similarly for transitions between higher-order structures.

33 so blocked discrete steps in the assembly of higher-order structures.

34 roteins that polymerize into filamentous and higher-order structures.

35 ers that in turn associate into a variety of higher-order structures.

36 through self-association of DBHS dimers into higher-order structures.

37 omplete folding can lead to the formation of higher-order structures.

38 NRL influence nucleosome array folding into higher-order structures.

39 iated regions of the cell, where they formed higher-order structures.

40 able to polymerize into apolar filaments and higher-order structures.

41 ce the propensity of Abeta to aggregate into higher-order structures.

42 nto coiled-coil structures and assemble into higher-order structures.

43 ed that HCF-1 self-associates into dimers or higher-order structures.

44 ssembly or the organization of hexamers into higher-order structures.

45 CMSD's self-assembly into the tetrameric and higher-order structures.

46 self-assemble into homodimer, tetramer, and higher-order structures.

47 l representations of degraded signals by the higher-order structures.

48 generation of the corresponding oligomers or higher-order structures.

49 bles the self-assembly of the particles into higher-order structures.

50 o influence the assembly and architecture of higher-order structures.

51 dynamics and the formation of VPS-dependent higher-order structures.

52 clei, this region forms multiple, nonrandom "higher order" structures.

53 cause of polymer formation with quinary, and higher-order, structures.

54 cription factors and can be compacted into a higher-ordered structure.

55 proper folding of nascent polypeptides into higher ordered structures.

56 e and n-hexadecyl-beta-D-maltoside Rho forms higher ordered structures.

57 ave shown the ability to more quickly access higher-ordered structures.

58 rikingly, chromatin shows greatly diminished higher-order structure after fertilization.

59 ed a nuclear imaging system to visualize the higher-order structures along with their dynamics in liv

60 associations to form elongated filaments and higher-order structures, an assembly process we call ann

61 y, the ability to detect changes in both the higher order structure and conformational dynamics of a

62 capable of providing valuable information on higher order structure and conformational dynamics of pr

63 ure of the PDC response is determined by the higher order structure and endosomal location of the CpG

64 of structural elements and enhancers to the higher order structure and expression of the CFTR locus.

65 Understanding protein higher order structure and interfacial interactions is c

66 Understanding higher order structure and its effect on protein stabili

67 data also indicate that the FSHR exists as a higher order structure and that it may heterodimerize wi

68 nding protein, can affect both the chromatin higher order structure and the modification of nucleosom

69 Maeshima investigates the higher order structures and dynamics of chromatin.

70 yntheses, play a role in assembling NCs into higher order structures and hierarchical superstructures

71 uanine or 7-deaza-2'-O-methyl-guanine avoids higher order structures and improves their inhibitory po

72 ins promote assembly of chromatin fibers and higher order structures and regulate gene expression rem

73 hat FoxI1 is capable of remodeling chromatin higher-order structure and can stably create site-specif

74 oligomeric state of FtsA may influence FtsZ higher-order structure and divisome function.

75 The design and construction of higher-order structure and function in proteinosome micr

76 ut they appear to play a specialized role in higher-order structure and function.

77 sites are likely to play a role in collagen higher-order structure and function.

78 onal protein Nervous Wreck (Nwk) has a novel higher-order structure and membrane-deforming activity t

79 Characterization of the higher-order structure and structural dynamics of protei

80 TR primary-site mutation proposed to disrupt higher-order structure and the RNA-silencing machinery.

81 to bind and cross-link actin filaments into higher-order structures and contribute to phagocytosis i

82 ch interactions are critical for assembly of higher-order structures and cooperative increases in GTP

83 Understanding the complexities of protein higher-order structures and dynamics requires integrated

84 ved, allow exploration of the antecedents of higher-order structures and generate testable hypotheses

85 The cell is constructed by higher-order structures and organelles through complex i

86 s, the protein-DNA interactions required for higher-order structures and recombination appear to be s

87 PR experiments failed to assemble into these higher-ordered structures and migrated as dimers.

88 probing of mutants indicated the presence of higher order structure, and sequences in the LS may also

89 sociate either in or out of register to form higher order structures, and mimics the banding found in

90 cus-level features are sufficient to explain higher-order structure, and identify the most influentia

91 for linking protein components into robust, higher-order structures, and expands the design space av

92 gions confirms that all measurable facets of higher order structure are conserved between human and m

93 on crystal dissolution indicating that these higher-order structures are produced dynamically during

94 contain all regulatory elements and preserve higher order structure as much as possible.

95 he scaffold for describing the mechanisms of higher order structures as organelles and cells.

96 -repeat expansion in FRDA cells stimulates a higher-order structure as a fragment containing the GAA-

97 earn action or state values without assuming higher-order structure as in standard reinforcement lear

98 MT)-organizing centers but failed to adopt a higher-order structure, as shown by three-dimensional st

99 soluble at low pH and self-assembles to form higher order structures at physiological pH.

100 ondensin in order to promote the assembly of higher-order structure at centromere and repetitive DNA.

101 The establishment and maintenance of higher-order structure at centromeres is essential for a

102 tin filaments are dynamically assembled into higher-order structures at specified locations to regula

103 (4.8.8) and (3.6.3.6), and one pattern with higher-order structures beyond the complexity observed i

104 It contains a G quadruple that leads to higher order structures by the formation of G tetrads.

105 Cells organize actin filaments into higher-order structures by regulating the composition, d

106 However, an RNA higher-order structure cannot be predicted accurately fr

107 ge-driven molecular dynamics, we studied the higher order structure changes of protein G'e at the mol

108 should be a valuable CL reagent for protein higher order structure characterization by MS.

109 Moreover, a higher-ordered structure, Co-Ni-Cu-O, was found to follo

110 -->4) and alpha(1-->6) linkages and exhibits higher order structures compared with chitin and cellulo

111 a high-throughput manner for batch-to-batch higher-order structure comparison, as well as for the op

112 sition, yet how a new subunit assembled into higher-order structures confers different functions is n

113 esponses, where primary DNA sequence and its higher-order structure constitute a regulatory context l

114 We propose that these putative higher order structures coordinate mitochondrial gene ex

115 noncanonical RNA:RNA interactions supporting higher-order structure critical for translation and repl

116 ssemble in a controlled way into fibrils and higher ordered structures depending on pH.

117 chimeric proteins into gradually developing, higher-order structures differently organized at early a

118 homodimerization, a crucial step in forming higher-order structures during assembly of the CSC.

119 (MS) has become a potent technique to probe higher-order structures, dynamics, and interactions of p

120 in contrast to enteric bacteria, do not form higher-order structures (e.g. ribosomal dimers) upon ent

121 valent homodimers as well as the assembly of higher-ordered structures essential for IFN-gamma bindin

122 ss only a minority of crystal forms, whereas higher-order structures exhibit common interfaces across

123 ancers, raising the possibility for a subtle higher-order structure extending across certain enhancer

124 coronaviruses, and (iii) SLVI is a required higher-order structure for DI RNA replication based on m

125 y biological processes are RNA-mediated, but higher-order structures for most RNAs are unknown, which

126 ion underlies the organization of cells into higher-order structures, for example during development

127 ve interactions between neighboring SBPs and higher order structure formation.

128 We conclude that higher-order structures formed by RNA and bound proteins

129 study provides insight into the formation of higher-order structures from self-assembling DNA origami

130 The accurate prediction of different RNA higher-order structures from their nucleic acid sequence

131 the filaments assemble on their own to form higher order structures, growing evidence suggests that

132 er, the extent of evolutionary divergence in higher order structure has not been rigorously measured

133 and to cross-link actin microfilaments into higher-order structures has been correlated with increas

134 The organization of DNA into nucleosomes and higher-order structures has profound implications for DN

135 interactors of insoluble proteins that form higher-order structures have remained challenges in biol

136 Protein higher order structure (HOS) describes the three-dimensi

137 yl NMR provides a powerful tool to probe the higher order structure (HOS) of monoclonal antibodies (m

138 The higher order structure (HOS) of proteins plays a critica

139 ics is the comprehensive characterization of higher order structure (HOS).

140 Higher-order structure (HOS) is a crucial determinant fo

141 ite-specific conjugation technologies on the higher-order structure (HOS) of mAbs.

142 The higher-order structure (HOS) of proteins plays a critica

143 Proteins adopt different higher-order structures (HOS) to enable their unique bio

144 n, devoting little attention to biomolecular higher-order structures (HOSs) which critically impact l

145 s (BCoV) genome is predicted to contain four higher-order structures identified as stem-loops I to IV

146 vestigate computationally how differences in higher-order structure impact on epidemic threshold, fin

147 distributions not only by affecting protein higher order structure in solution but also through modu

148 s enzyme is a mixture of monomer, dimer, and higher order structures in solution.

149 tures remain rare, despite the importance of higher-order structure in biomacromolecules.

150 ivative, CL67, which binds to a G-quadruplex higher-order structure in the HIF promoter sequence in v

151 of this segment of Gag, show that it is in a higher-order structure in the virus particle, and provid

152 dor representations is therefore mediated by higher-order structure in the wiring diagram that is ada

153 involves the modification of chromatin, the higher-order structure in which DNA is packaged.

154 e but not the negative strand, and (iv) as a higher-order structure in wild-type (wt) and mutant mole

155 he propensity of dynamin to oligomerize into higher-order structures in an actin-dependent manner and

156 eteromeric complexes that form filaments and higher-order structures in cells.

157 t is unknown how septins are arranged within higher-order structures in cells.

158 termines its intrinsic roles in facilitating higher-order structures in CSCs.

159 Characterization of the higher-order structures in idursulfase (iduronate-2-sulf

160 DNA is organized and compacted into higher-order structures in order to fit within nuclei an

161 s, Spr28-Spr3-capped rods are unable to form higher-order structures in solution but assemble to form

162 ch conformer (PrP(Sc)) that accumulates into higher-order structures in the brain and other tissues.

163 that do not tolerate mutations contribute to higher-order structures in VLPs.

164 materials hierarchically self-assemble into higher-order structures, in which, according to molecula

165 ved, GTP-binding proteins that assemble into higher order structures, including filaments and rings w

166 Higher-order structure influences critical functions in

167 The usefulness of the higher-order structure information provided by hydrogen/

168 Together, our results strongly suggest that higher-order structures integrate inputs across afferent

169 three such ligands required to guarantee the higher-order structure integrity.

170 ts suggest that the NRL may direct chromatin higher-order structure into either a nucleosome position

171 aken together, these data suggest that local higher order structures involving AREs may function as p

172 al-life decision-making problems incorporate higher-order structure, involving interdependencies betw

173 urements provide a clear indication that the higher order structure is affected well beyond the coval

174 The organization of chromatin into higher order structures is essential for chromosome segr

175 Condensation of chromatin into higher order structures is mediated by intra- and interf

176 The self-assembly of proteins into higher order structures is ubiquitous in living systems.

177 nal lipid bilayers, in which the assembly of higher-order structures is also mediated by complex memb

178 f-assembly of molecular building blocks into higher-order structures is exploited in living systems t

179 Whether pairwise loops synergize to form higher-order structures is still unclear.

180 e mechanisms that fold chromatin fibers into higher-order structures is therefore key to understandin

181 ll-length IFN-gammaBPs were observed to form higher-ordered structures larger than the previously rep

182 generated from actin filaments arrayed into higher-order structures like actin cables and bundles.

183 Higher-order structures like fibril bundles and fibers a

184 n of PopZ relied on its self-assembly into a higher-order structure (matrix) and that the unipolar to

185 ter denaturation of RNA, suggesting that the higher order structure may contribute to the greater iro

186 We detected the presence of a localized higher-order structure motif in the pro-part of proNGF.

187 Higher-order structure must affect these reactions if th

188 e rapid, high-resolution analyses of protein higher order structures needed to ensure drug efficacy a

189 The E. coli FtsZ chimera readily formed higher order structures normally seen only in the presen

190 mportant characterization information on the higher order structure of antibodies and conformational

191 e used to quickly provide information on the higher order structure of antibody therapeutics.

192 ll-length S glycoprotein of SARS-CoV forms a higher order structure of approximately 500 kDa, which i

193 The higher order structure of chromatin in vivo is criticall

194 K20 is involved in the maintenance of proper higher order structure of DNA and is consequently essent

195 ental evidence that UVPD is sensitive to the higher order structure of gas-phase proteins.

196 merged as a premier tool to characterize the higher order structure of protein therapeutics and in pa

197 To explore the higher order structure of transcribable chromatin in viv

198 The higher order structure of viral RNA appears to be an imp

199 Chromatin in eukaryotic cells is folded into higher order structures of folded nucleosome filaments,

200 ble for identification of differences in the higher order structures of proteins.

201 identification of cis-regulatory modules and higher order structures of the regulatory sequences, whi

202 elopment of an RNA interactome that maps the higher-order structure of a postulated RNA domain within

203 the utility of HDX-MS for interrogating the higher-order structure of ADCs and other protein therape

204 ified by the folded secondary, tertiary, and higher-order structure of biomolecules.

205 -a feature critical for stabilization of the higher-order structure of chromatin and for repression o

206 The complex regulates the higher-order structure of chromatin, and has important r

207 in model, can be largely accommodated by the higher-order structure of chromatin.

208 nucleosomes, which further compact into the higher-order structure of chromatin.

209 mes and to exploration of the epigenome, the higher-order structure of DNA that dictates the expressi

210 The higher-order structure of heterochromatin contributes to

211 spectrometry approach for characterizing the higher-order structure of intact antibodies, by combinin

212 nd show utility for studying the primary and higher-order structure of peptides and proteins.

213 y (MS) are increasingly being used to obtain higher-order structure of proteins and protein complexes

214 st direct methodology for characterizing the higher-order structure of proteins in solution.

215 Intuitively, learning the higher-order structure of statistical relationships shou

216 ctor binding, RNA polymerase pausing and the higher-order structure of the chromatin fibre.

217 fferences in morphology and composition, the higher-order structure of the inner and outer rings is u

218 cleotide substitutions that alter either the higher-order structure of the panhandle or the primary s

219 ages is a new property that emerges from the higher-order structure of the protein cage, rather than

220 ippocampal patients were unable to grasp the higher-order structure of the task with the same success

221 nes play important roles in the formation of higher-order structures of chromatin and the regulation

222 gered, likely important for the formation of higher-order structures of different shapes.

223 We propose that filaments or other higher-order structures of ICP8 may provide a scaffold o

224 both ScpA and ScpB favored the formation of higher-order structures of SMC complexes, suggesting a r

225 nsuring the correct assembly, stability, and higher-order structures of these important biomolecules

226 Since the conformation (or higher order structure) of a protein is a major modulato

227 Significantly, higher-order structures (oligonucleotides, peptides and

228 d others to hypothesize that SIRPalpha forms higher order structures on the cell surface.

229 homolog in groups 1 and 3, (ii) exists as a higher-order structure on the basis of enzyme probing, (

230 Septins form higher-order structures on fungal plasma membranes and a

231 GTP-binding proteins that form filaments and higher-order structures on the cell cortex of eukaryotic

232 Thus, the DCC imposes a distinct higher-order structure onto X chromosomes while regulati

233 on of many viruses involves the formation of higher-order structures or replication "factories." We s

234 ntation of molecules while they form dynamic higher-order structures, our approach can provide insigh

235 The assembly of DNA duplexes into higher-order structures plays a major role in many vital

236 performed a simple decision-making task with higher-order structure, probabilistic reversal learning.

237 We postulate that the higher-order structure promotes (+)-strand synthesis.

238 ons, indicating the involvement of chromatin higher-order structure rather than nucleosomes in the re

239 epigenetic factors, organizes the genome in higher order structures required for transcriptional con

240 There, Gag forms higher ordered structures required for the correct assem

241 on the ability of the 3D polymerase to form higher-ordered structures required for positive-strand R

242 els of SAS-6 in Drosophila cells resulted in higher order structures resembling central tubule morpho

243 yotic DNA is sequestered as nucleosomes, the higher-order structure resulting from nucleosome interac

244 ence-directed versatile assembly of periodic higher-order structures reveals a general organizational

245 Instead, stimulatory activity resides in higher-order structured RNA that contains single-strande

246 first tetrapods to man, that is crucial for higher order structure self-assembly of the key intrinsi

247 asing attention due to their ability to form higher ordered structures similar to proteins.

248 tion and equal clustering, exhibit different higher-order structure, specifically, overlapping triang

249 is required to promote further assembly into higher order structures such as rings or spirals.

250 and disassembly of actin into filaments and higher order structures such as stress fibers and lamell

251 n molecules form fibrils, which arrange into higher-ordered structures such as fibers and fascicles.

252 l is known about the components that include higher order structures, such as lamellar meshes, filopo

253 lexes that assemble into filaments and other higher-order structures, such as rings or hourglasses, a

254 Two designed peptides that formed higher-order structures suggest how future design protoc

255 er cell and is packaged into several hundred higher-order structures termed nucleoids.

256 es from a single origin are colocalized into higher-order structures termed replication factories.

257 ent with a computational model that exploits higher-order structure than with simple reinforcement le

258 The large GTPase dynamin assembles into higher order structures that are thought to promote endo

259 n conveyed by DNA sequence and chromatin are higher order structures that encompass portions of chrom

260 ides to the protein induced the formation of higher order structures that may represent biocrystallin

261 ith the posterior medial thalamic nucleus, a higher-order structure that carries both top-down and bo

262 to the tetrameric state, forming a transient higher-order structure that drives both the activating a

263 onetheless, has an RNA genome with a complex higher-order structure that likely reflects high informa

264 n limit of HX-MS for detection of changes in higher-order structure that might be encountered in prot

265 Genomic DNA is folded into a higher-order structure that regulates transcription and

266 Septins assemble into filaments and higher-order structures that act as scaffolds for divers

267 ence of the PAR confers unique chromatin and higher-order structures that are crucial for recombinati

268 sistent with roles in modulating assembly of higher-order structures that are unique to individual or

269 Pentameric DdrB was found to assemble into higher-order structures that coat ssDNA.

270 igins: the use of landmarks, the creation of higher-order structures that enable geometric sensing, a

271 ary-structure epitopes found on E dimers and higher-order structures that form the viral envelope.

272 linear sequence of their RNA genomes and in higher-order structures that form when the genomic RNA s

273 Higher-order structures that originate from the specific

274 re both in vivo and in vitro, forming stable higher-order structures that were resistant to depolymer

275 hromatin and defects in PcG protein-mediated higher-order structures, thereby leading to impaired PcG

276 d nucleosomes, reflecting a fibre of uniform higher-order structure, this organisation is disrupted b

277 uence the folding of a nucleosome chain into higher-order structure; this hypothesis was borne out in

278 tributions by proteins involved in mediating higher order structure to DNA DSB responses.

279 mers and established the importance of these higher order structures to intracellular trafficking and

280 ) alone in the receptor directly assembles a higher-order structure to drive signaling and that this

281 tic spectrum by which proteins assemble into higher-ordered structures to achieve membrane deformatio

282 these side chains, as formed by a protein's higher order structure, tunes their reactivity such that

283 It has been proposed that MDA5 forms higher-order structures upon viral dsRNA recognition or

284 diffusion-driven process, while formation of higher-order structures was complex and involved self-te

285 To identify and quantify such higher order structure, we applied Raman optical activit

286 on binding capacity, and the ability to form higher-order structures were also examined for each muta

287 bearing halogen bond-accepting amine groups, higher-order structures were obtained in both organic so

288 ctin filaments promote dynamin assembly into higher order structures, which in turn efficiently relea

289 his hypothesis depends on the formation of a higher-order structure, which has yet to be identified u

290 f GTP-binding proteins that oligomerize into higher-order structures, which associate with membranes

291 ase-primase requires formation of a dimer or higher-order structure while ATPase activity does not.

292 elles, which extend and coalesce to form the higher order structures with a rate and a degree of coop

293 Taken together, CEACAM16 can probably form higher order structures with other tectorial membrane pr

294 y: meaningful words are combined into larger/higher-order structures with derived meaning.

295 binding site may thus allow access to other higher-order structures with multimetallic vertices.

296 Most classes showed a disruption of the higher order structure, with the degree of disorder depe

297 terminase adopts a heterogeneous mixture of higher-order structures, with an average molecular mass

298 l that cytosolic proteins are organized into higher order structures within axon-enriched fractions t

299 We find evidence for higher-order structure within satDNA arrays that suggest

300 can interactions that drive the formation of higher-order structure within the glycan shield.