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1 ergy transfer within ice giants, our results highlight the need for a deeper understanding of the che
4 LASV) in overlapping endemic areas of Africa highlight the need for a prophylactic vaccine that would
6 t effects that we identified, these findings highlight the need for a rigorous safety assessment of n
8 therapy in adults with COPD or ILD but also highlight the need for additional research to guide clin
12 modern high energy-dense rechargeable cells highlight the need for advanced battery screening techno
14 biological sequence data heterozygosity, we highlight the need for better measures of assembly quali
15 istic relationships between these constructs highlight the need for better understanding of their bi-
18 f potentially confounding genetic events and highlight the need for careful characterization of each
19 in the regulation of energy homeostasis and highlight the need for careful consideration of its deve
24 s to effective long-term therapeutic success highlight the need for continued drug development using
25 reases in importation and global circulation highlight the need for coordinated initiatives to reduce
26 in order to raise the index of suspicion and highlight the need for correct and timely diagnosis.
27 results guide the interpretation of TWAS and highlight the need for corroborative data to provide con
29 rtcomings of current training strategies and highlight the need for developing new optimal metrics to
30 are not attenuated by carvedilol therapy and highlight the need for development of specific combinato
31 h focused mainly on part of the E1 gene, and highlight the need for direct measurements of mutation r
32 d by behavioral and neurobiological data and highlight the need for diversifying the field in order t
33 some states and among younger and black PLWH highlight the need for early diagnosis and treatment of
35 Disparities in hypertension control by sex highlight the need for effective interventions among you
36 ng advanced EMI shielding materials but also highlight the need for exploring fundamental mechanisms
42 ion, synaptic dysfunction, and inflammation, highlight the need for further research into common copa
45 regulating excessive alcohol consumption and highlight the need for future studies to examine how thi
46 ry tools that can guide spatial sampling and highlight the need for greater use of mixed-effects mode
48 and lack of effective antifibrotic therapies highlight the need for identification of pathways and co
50 hospitalization stay; these findings further highlight the need for implementation of patient-based p
51 h deaths in Australia's Murray-Darling Basin highlight the need for improved conservation methods for
56 ction and predicted climate change scenarios highlight the need for improvements in crop sustainabili
61 the potential adverse effects of CAR T cells highlight the need for mechanisms to modulate CAR T-cell
62 uronal function during tissue remodeling and highlight the need for mechanistic studies that consider
64 ke, dementia and lower QALYs after lobar ICH highlight the need for more effective prevention for thi
67 ign are crucial for biological activity, and highlight the need for more studies to determine the com
68 rpretation of TSPO in multiple sclerosis and highlight the need for neuropathological characterizatio
69 the P3b as a neural marker of awareness and highlight the need for new approaches to the neuroscienc
71 anatomical variation across individuals and highlight the need for new technologies and analytical m
72 e mesenchymal compartment of BT BM niche and highlight the need for novel strategies to target the ni
75 d depression, and the results of this review highlight the need for ongoing, long-term mental health
76 DSA and the correlation with acute rejection highlight the need for optimizing immunosuppression, clo
77 ten strength of biological impacts we reveal highlight the need for outdoor artificial night-time lig
78 inflammation by C5a-C5aR1 signaling in brain highlight the need for precision of therapeutic design.
83 ized medicine for next-generation healthcare highlight the need for sensitive and accurate point-of-c
92 essful RV144 HIV vaccine trial in humans and highlight the need for the development of improved HIV e
95 andemic, caused by the SARS-CoV-2 virus, has highlighted the need for antiviral approaches that can t
96 ity wounds in recent military conflicts have highlighted the need for clinical decision support tools
98 t clinical trials in Alzheimer's disease has highlighted the need for the development of a more compl
100 e evasion and regulation of gene expression, highlighting the need for a multifaceted intervention ap
101 a stagnation in the decline of TB incidence, highlighting the need for additional interventions inclu
102 , related to study design and parasite type, highlighting the need for additional multiscale research
103 nts respond to T-cell checkpoint inhibitors, highlighting the need for alternative immunotherapeutics
104 ct the domains of Bub1 necessary for arrest, highlighting the need for Bub1-CD1, which binds Mad1 [9]
105 are identified and which ones may be missed, highlighting the need for careful consideration of the s
106 pared to snails exposed for short durations, highlighting the need for caution when conducting acute
107 the previously reported Ker14-Cre/Stim1 cKO, highlighting the need for cell- and stage-specific Cre l
108 l location and history of travel, as well as highlighting the need for commercially available specifi
109 ix African countries (16 from South Africa), highlighting the need for data from a broader range of A
111 igh-resolution decision aids for management, highlighting the need for EEZ-specific analyses in addre
112 mainly by older individuals aged >=65 years, highlighting the need for effective regular screening an
114 t of conflicts of interest - with the aim of highlighting the need for ethical analysis of specific i
115 e to maintain current community composition, highlighting the need for external recruitment sources t
116 r and noncardiovascular hospital admissions, highlighting the need for focus on underlying morbidity
117 ation and virulence appear to vary by genus, highlighting the need for further functional studies to
118 eractions for diet response prediction while highlighting the need for further research and larger sa
120 of complex diseases for admixed individuals, highlighting the need for further study of these populat
121 dental diagnoses and low provider suspicion, highlighting the need for improved awareness about this
122 with current oversimplified membrane models highlighting the need for improved epithelial membrane m
123 verse effects and are potentially addictive, highlighting the need for improved therapeutic agents.
124 g 2013-17 were programmatically preventable, highlighting the need for improving the effectiveness of
125 valence of 2-5% in Europe and North America, highlighting the need for increased diagnosis and treatm
126 could generate spatial variation in defence, highlighting the need for large-scale studies that can d
127 eported in populations of European ancestry, highlighting the need for larger studies, particularly i
128 hich may impact the linkages they construct, highlighting the need for management plans that transcen
129 ich complicates its production in pure form, highlighting the need for metabolic engineering approach
130 as 3.3 years among people diagnosed in 2015, highlighting the need for more effective strategies for
131 as 3.3 years among people diagnosed in 2015, highlighting the need for more effective strategies for
132 tic algorithms driven by rifampicin testing, highlighting the need for new rapid molecular technologi
133 ug-resistant mutants is observed frequently, highlighting the need for novel antiviral therapies.
134 ncentrations consistent with poor adherence, highlighting the need for novel approaches and long-acti
135 an first-generation antiseizure medications, highlighting the need for novel strategies in epilepsy d
136 currently available are minimally effective, highlighting the need for novel therapeutic intervention
137 all cases, we find hallmarks of generic DE, highlighting the need for nuanced interpretation of gene
138 improve transparency in the PBM industry and highlighting the need for reliable, timely, and relevant
139 in MPA planning derive from tropical reefs, highlighting the need for research in other ecosystems a
141 gh the impact is scale and context specific, highlighting the need for safeguards to ensure that expa
143 uptake and population-level HIV reductions, highlighting the need for simplifying delivery and reduc
144 g fisheries targeting transboundary species, highlighting the need for strengthened effective and equ
146 fic differences in AML have been identified, highlighting the need for tailored treatments for paedia
148 do not benefit from checkpoint blockade(12), highlighting the need for targeting of alternative immun
149 berrations that could confound quantitation, highlighting the need for the "aberration compensated" a
150 s differentiation remains a major challenge, highlighting the need for understanding developmental me
151 The rapid increase of global temperatures highlights the need for a clear assessment of how sex ra
154 cale of reductions in ecosystem CO(2) uptake highlights the need for a process-based understanding of
155 at doses found in nuclear waste streams and highlights the need for a systematic approach to underst
158 ecurrence due to endocrine resistance, which highlights the need for additional predictive and progno
162 bitats for framework-forming DWC species and highlights the need for conducting more systematic surve
164 ed by the Betacoronavirus SARS-CoV-2 (SCoV2) highlights the need for coordinated research to combat C
165 d community with intense household crowding, highlights the need for coordinated, interdisciplinary,
166 ration of infection after symptom resolution highlights the need for diagnostic MG testing of men wit
168 ratory health and environmental hazards, and highlights the need for further experimental constraints
169 ly, there is no cure for this disease, which highlights the need for further investigation about the
171 ciated with the HSS intervention, this study highlights the need for further quality improvement in c
175 predominant disorders identified, this study highlights the need for increased owner awareness to man
176 result from changes in the distant past, and highlights the need for integrating evolutionary dynamic
177 functional dimensions in tropical trees and highlights the need for integrating tree physiological a
179 fts to rapid changes in climate and land use highlights the need for new biogeographic frameworks to
180 The low and homogeneous rate of HBsAg loss highlights the need for new therapeutics aimed at achiev
181 represents a major global health problem and highlights the need for novel anti-infective therapies.
183 patient characteristics and hospital volume highlights the need for patient selection and surgical e
184 of progression of COVID-19 lung disease and highlights the need for peripheral blood biomarkers that
186 er disease burden in lower-resource settings highlights the need for public health efforts aimed at i
189 ality reflects the burden of comorbidity and highlights the need for risk-reducing interventions.
190 and for high-capacity rechargeable batteries highlights the need for sensitive and accurate diagnosti
191 rule than the exception, but the study also highlights the need for similar high spatial resolution
192 neity of hot particles on a micrometer scale highlights the need for spatially resolved techniques to
195 rise of gonococcal antimicrobial resistance highlights the need for strategies that extend the clini
196 Niger's dynamic Nm serogroup distribution highlights the need for strong surveillance programs to
197 patients; the Mumtaz readmission risk score highlights the need for targeted interventions in order
199 with expanded virus-specific CD8(+) T cells highlights the need for targeting other adaptive immune
200 poor regenerative capacity of neural tissue highlights the need for the development of cellular envi
201 multiple existing non-classical theories and highlights the need for the direct evidence presented by
203 n extended and nanoscale Pt surfaces, and we highlight the needs in advancing both characterizations
205 als has yielded promising antitumor effects, highlighting the need of systematic analysis of neural i
208 perspective on Holocene ENSO variability and highlight the need to address ENSO reconstruction with a
209 nature and the ecology of CWD in Europe, and highlight the need to assess the zoonotic potential of t
211 ted with various potable reuse scenarios and highlight the need to carefully consider drinking water
214 different results reported by other studies highlight the need to conduct longitudinal studies acros
215 tators of HIV dispersal throughout China and highlight the need to consider harmonized country-wide p
216 ne-associated rainfall in the North Atlantic highlight the need to consider how such shifts, together
218 Ca and not only bridge the knowledge gap but highlight the need to consider SPARC protein expression
220 tion in response to reduced PP(i) conditions highlight the need to consider tissue-specific responses
221 inders to mitigate environmental burdens and highlight the need to consider trade-offs among environm
223 metastatic progression of breast cancer and highlight the need to control PI, a pervasive inflammato
224 in the environment under certain conditions, highlight the need to develop effective decontamination
229 t reliant upon active SIRT3, and our results highlight the need to examine known roles of SIRT3 in th
230 ross maternal immune activation studies also highlight the need to examine preclinical offspring neur
233 on of CRBN with endothelial cell targets and highlight the need to further elucidate the mechanism(s)
236 tance and the failure to eradicate infection highlight the need to identify new pathways to target th
239 ibility to neurodegenerative disease, and we highlight the need to investigate the contribution of mo
245 nd timing of the Deepwater Horizon oil spill highlight the need to study oil and hypoxia exposure in
251 lementation of new eco-friendly solvents has highlighted the need to analyse both the structures and
252 of forest biomass in Paleotropical locations highlighted the need to incorporate variation in hydraul
253 n and increasing environmental problems have highlighted the need to research new eco-friendly solven
254 tant genes and are in human clinical trials, highlighting the need to carefully consider the normal f
255 slope, wilderness status, and other factors, highlighting the need to complement disposal via biomass
256 efore, increase with repeated introductions, highlighting the need to constrain future introductions
257 (s) effects were detected in some behaviors, highlighting the need to control for G(i)xG(s) effects w
258 on in well-detector gamma spectroscopy, thus highlighting the need to correct for this TDS-influenced
259 d with a significant delay in EVT initiation highlighting the need to develop more efficient stroke s
260 oxicities and obesity-related complications, highlighting the need to develop novel therapeutic appro
261 s with cancer benefit from these treatments, highlighting the need to identify new cells and molecule
262 lable for patients with KRAS-driven cancers, highlighting the need to identify new molecular targets
263 d quality of life as patients age worldwide, highlighting the need to investigate the critical uncert
264 concentrations of urea and shellac, further highlighting the need to maximize coating transfer effic
265 that acts upon it, as well as more generally highlighting the need to measure colour objectively in o
266 endent manifestation of membrane properties, highlighting the need to reassess cholesterol's role in
267 risk for COVID-19 and its adverse outcomes, highlighting the need to screen and treat individuals wi
268 resulted different performance in each site, highlighting the need to select scores based on the popu
269 rtant factor determining treatment response, highlighting the need to take drug levels into account w
270 reveal plasticity of CSC maturation in AML, highlighting the need to therapeutically eradicate cance
271 ccurs after several months in most patients, highlighting the need to understand mechanisms of resist
272 nked to cancer and mental illness disorders, highlighting the need to understand the molecular mechan
273 via angiotensin-converting enzyme 2 (ACE2), highlighting the need to understand the relationship bet
278 C>T SNP and breast-milk UMFA, albeit modest, highlights the need to better understand the determinant
282 trates that sizers are important in vivo and highlights the need to determine their underlying molecu
283 etween measures of pain and IVD degeneration highlights the need to evaluate pain or nociception in I
285 antibiotic resistance expressed by gonococci highlights the need to find alternative approaches to cu
288 the events of HIV replication and therefore highlights the need to have optimum translational interv
289 at can be used to assess resistance risk and highlights the need to include spatial or demographic he
294 CH(4) than previously thought, our research highlights the need to reappraise trace gas budgets in t
298 ls using mRNA to modulate inflammation, this highlights the need to understand inflammatory signaling
299 Prevalence of drug-resistant P. falciparum highlights the need to understand the biology of resista