ライフサイエンスコーパス: highly

1 Flow cytometry of the five most highly abundant peptides (EP1, -2, -3, -7 or EP9) showed

2 The machine learning produced highly accurate and robust classification of resistance

3 ently emerged as powerful tools for building highly accurate PESs for relatively large molecular and

4 We present highly accurate real-time pH measurements of microdrople

5 knowledge of reference genomes and produces highly accurate results, even at a strain level.

6 ries the height of a ground plane, providing highly accurate, millisecond, displacement.

7 Our data suggest that MAIT cells are highly activated and become dysfunctional during clinica

8 The MAPK pathway is often found to be highly activated in TNBC, however the precise functions

9 ts physiological transporter GBIHBP1 that is highly active and largely resistant to physiological inh

10 Venetoclax is highly active at achieving deep remission for most treat

11 Applying harsh conditions, highly active catalysts or highly reactive bonding group

12 The Ocn-Cre(+) dDG neurons were highly active in response to anxiogenic environment but

13 e activity with SAC; however, the enzyme was highly active with l-cysteine, N-acetyl-l-cysteine, and

14 loss and morphological reductions seen among highly adapted aquatic species.

15 eral nerve sheath tumors (MPNSTs), which are highly aggressive sarcomas that originate from cells of

16 Glioblastoma (GB) is a highly aggressive, difficult to treat brain tumour.

17 PA to pre-existing p53-deficient tumors in a highly aggressive, immunocompetent mouse model of lung a

18 Mesothelioma is highly aggressive; its sarcomatoid variants have worse p

19 ighly conducting pure MXene films containing highly aligned large MXene flakes.

20 Heather honey is highly appreciated by consumers for its sensorial profil

21 atured in 18 of the top 20 combinations most highly associated with mortality in UK Biobank and 12 of

22 We show that these filaments are coated by a highly asymmetric, multi-component sheath layer, contras

23 agents, boasts a wide scope, and can be made highly atom economic, makes this new methodology a very

24 dividuals with naturally acquired antibodies highly blocking the binding of PvDBP to the Duffy recept

25 The kidney is comprised of highly complex structures that rely on self-maintenance

26 d is shown for the fabrication of strong and highly conducting pure MXene films containing highly ali

27 Solution-processable highly conductive polymers are of great interest in emer

28 tional DNA substrate for the unessential but highly conserved A* protein.

29 4A1) is a cytosolic sulfotransferase that is highly conserved across species and extensively expresse

30 The Src homology 2 (SH2) domain has a highly conserved architecture that recognizes linear pho

31 ells in the colitis response and shows how a highly conserved chromatin remodeling factor has a disti

32 In this opinion article, we propose that highly conserved DNA methyltransferases (MTases) represe

33 findings show that small changes outside of highly conserved DNA-binding regions can lead to profoun

34 Targeting highly conserved genomic regions make pan-family assays

35 Hsp90 is a highly conserved molecular chaperone important for the a

36 Zn(2+) binding sites within each subunit: a highly conserved primary site in transmembrane domain (T

37 identified three such epitopes derived from highly conserved regions within LASV proteins.

38 lysis and cell culture studies to identify a highly conserved regulatory mechanism linking anxiety an

39 rdiomyocyte maturation trajectories identify highly conserved signaling pathways, pharmacological tar

40 several variants in which one or two of four highly conserved Trp residues in the binding tunnel had

41 Phylogenetic analysis showed Asp t 36 to be highly conserved with close similarity to the triose-pho

42 RNase P and MRP are highly conserved, multi-protein/RNA complexes with essen

43 The changes of stress ratio were highly consistent with clinical data on bifurcation sten

44 hain apex, polar bears (Ursus maritimus) are highly contaminated with persistent organic pollutants (

45 uced across multiple studies and many appear highly context-specific.

46 re sequencing with Hi-C scaffolding produces highly contiguous, chromosome-length scaffolds, and we i

47 required for the sustained stabilization of highly contractile actomyosin structures.

48 lidated for single time-point assessment, in highly controlled settings, and with relatively homogene

49 as revealed that the Orai1 gating process is highly cooperative and strongly allosteric, likely drive

50 in transduces chemoreceptor stimulation to a highly cooperative flagellar motor response.

51 formation from similar sensory space exhibit highly correlated electrical activity that is critical f

52 pattern repetitions; and importantly, it is highly correlated with behavioral learning outcomes.

53 t 1, segmentation-free RNFL predictions were highly correlated with conventional RNFL thickness (r =

54 nd to be 105 h, 48 h, and 17 h respectively, highly correlated with TVB-N, TVC, pH and sensory evalua

55 ial circRNA-disease associations and provide highly credible candidates for biological experiments.

56 ugh shown by in situ X-ray diffraction to be highly crystalline in the reaction mixture, is much less

57 be dependent on underlying cycle length in a highly curvilinear fashion with the dependency significa

58 Systems of highly degenerate frozen states may exhibit the rare and

59 Recognition of highly degenerate mammalian splice sites by the core spl

60 andardised HRCT score system for COVID-19 is highly demanded.

61 is process with single-particle precision is highly demanding, mostly due to insufficient understandi

62 Honey bees are highly dependent on circadian clocks to regulate critica

63 Management of fisheries that are highly dependent on reefs may need to adapt to declining

64 single-crystal TiO(2)(110)) was found to be highly dependent on the anchor group, with Ipa establish

65 cal coral populations at higher latitudes is highly dependent on the persistence of up-current tropic

66 rsible shape transformation and locking, are highly desirable for a plethora of applications, includi

67 with high phosphorus use efficiency (PUE) is highly desirable for organic pulse crop biofortification

68 ve countermeasures against these viruses are highly desired.

69 Through this work, we have made available a highly-detailed data source for future investigation.

70 yme-catalyzed malonate desymmetrization, and highly diastereoselective nitrile oxide cycloaddition.

71 are unique among primates in that we consume highly digestible foods, wean early, mature slowly, and

72 predicted to be piezoelectric because of its highly directional properties and non-centrosymmetric la

73 AcrIIA1 also uniquely inhibits a highly diverged Cas9 found in Listeria (similar to SauCa

74 Nursing homes have highly divergent urine culturing rates; this variability

75 brain, the blood, and the lung, and thus in highly diverse and dynamic environments.

76 data from dead minds open up an untapped and highly diverse subject pool.

77 potential of cells, termed pluripotency, is highly dynamic and progresses through a continuum of nai

78 quid-liquid phase separation (LLPS), forming highly dynamic liquid droplets.

79 Mitochondria are highly dynamic organelles that can exhibit a wide range

80 This complex and highly dynamical chemical process involves assembly and

81 hematite, an earth-abundant material, to be highly effective and thermally stable to catalyze methan

82 Anti-interleukin-6-directed therapies are highly effective in many iMCD patients, but additional t

83 Weight loss is highly effective in preventing T2D; however, the at-risk

84 Treatment for LTBI was highly effective in preventing TB among close contacts o

85 ting the size of the central acene ring is a highly effective molecular design strategy to optimize t

86 icyclo[1.1.1]pentane (BCP) have been used as highly effective phenyl mimics.

87 ented reactivity, acting as a convenient and highly effective precursor for selective formation of br

88 TE is well tolerated in BALB/c nude mice and highly efficacious against AR42J tumors in vivo.

89 ethylbutyryl)taxol side chain), TmAAE15 as a highly efficient candidate for hexanoic acid activation

90 with the latter showing excellent promise as highly efficient catalysts under inert atmosphere condit

91 hieve very rapid (picosecond time scale) and highly efficient energy transfer (around 90% efficiency)

92 etic zinc-imidazole frameworks (ZIF-4), as a highly efficient media for on-line separation of phenoli

93 This highly efficient multiplex CRISPR/Cas9_Trex2 system make

94 Here, we describe a rare case of highly efficient near-cognate initiation.

95 esign a Th-metal-organic framework (MOF) for highly efficient separation of C(2)H(4) from a binary C(

96 In this study, we established a highly efficient synchronization method for G2/M phase o

97 hat the sensory correlates of frequency were highly electrode dependent: On some electrodes, changes

98 Recently a highly enantioselective and regioselective protocol for

99 ming prion strains instead developed plaques highly enriched in ADAM10-cleaved PrP and heparan sulfat

100 Exosomes are highly enriched in tetraspanins (TSPNs) and syndecans (S

101 l toxins disarm their targets emphasizes the highly evolved nature of these processes.

102 here offer prospects for tailored design of highly evolved, genetically encoded organophosphorus sca

103 Fish have been highly exposed to radiation in freshwater systems after

104 hages are likely targets as these cell types highly expressed 15-PGDH.

105 We found that lon-1 was highly expressed during animal infection, implying an im

106 restricting to LOF variants located in exons highly expressed in cardiac tissue (TTN(LOF)).

107 NA transcripts and protein isoforms that are highly expressed in central nervous system cells.

108 ant excess of loss-of-function DNMs in genes highly expressed in craniofacial tissues, as well as gen

109 LIN28B is highly expressed in neuroblastoma and promotes tumorigen

110 idate gene (ILDR1), which encodes a receptor highly expressed in prostate tissue and is related to th

111 The transcription factor JUN is highly expressed in pulmonary fibrosis.

112 -A orphan G-protein-coupled receptor that is highly expressed in the brain and represents a promising

113 While both LASP1 and LASP2 are highly expressed in the brain, little is currently known

114 alpha5, beta2, beta3, gamma2, and delta were highly expressed in the dentate molecular layer, whereas

115 mouse alkaline ceramidase 2 gene (Acer2) is highly expressed in the placenta between embryonic day (

116 Siglec-8 is highly expressed on eosinophils and mast cells in asthma

117 s, we show that chromatin remodeler Hmga1 is highly expressed prior to specification and maintained i

118 pairs of faces in two conditions: a famous, highly familiar face with a novel face or two novel face

119 They are highly fecund, optically clear and an excellent platform

120 usly shown to interact with CNBP, contains a highly flexible loop surrounded by more ordered helices.

121 er-like substrate, which is polycrystalline, highly flexible, ultralong, and mechanically stable.

122 The derivatives are highly fluorescent and feature low oxidation potentials.

123 calized high-concentration electrolytes, and highly fluorinated electrolytes, surface coatings that c

124 d that Tim-3 was preferentially expressed on highly functional ganglionic CD8(+) T cells during acute

125 enchymal cells that support formation of the highly functional tooth root and the periodontal attachm

126 ment of synthetic materials that rival their highly functional, natural counterparts.

127 We contend that ice sheets create highly geochemically reactive particulates in subglacial

128 fectiveness of implementing national bans of highly hazardous pesticides to reduce the burden of pest

129 ity of computational stability predictors is highly heterogeneous across different proteins, and that

130 , current protocols yield either complex but highly heterogeneous aggregates ('organoids') or 3D stru

131 Thus, BLA excitatory neurons are a highly heterogenous collection of neurons that spatially

132 water flow and reef morphology resulted in a highly heterogenous physical environment even within iso

133 ound that when expressed in human cells, two highly homologous HSP70s, HSPA1A and HSPA1L, have opposi

134 Fungi (the mycobiota) represent a highly immunologically reactive component of the gut mic

135 oma immune microenvironment is recognized as highly immunosuppressive, posing a major hurdle for indu

136 the phase transition from gel to crystal are highly important for the development of various function

137 based on the murine brain samples revealed a highly improved annotation quality as measured by sensit

138 zing power of sMMO-Q necessary to attack the highly inert C-H bonds of methane.

139 The highly infectious and zoonotic pathogen Francisella tula

140 They are also highly infectious in their homologous host species.

141 nd transport behaviors of phosphate ions are highly influenced by electrolyte pH, and it used experim

142 We found that ECoGs were highly informative and outperformed other signals in inf

143 usion, this in vivo study confirms that Scia highly inhibits SCD1 expression and activity.

144 termination converts from SrO to RuO(2) , a highly insulating and nonferromagnetic phase emerges wit

145 rimental models and humans have identified 9 highly interconnected hallmark processes driving mammali

146 This secretome consists of a highly interconnected network enriched in RNA-binding pr

147 In the highly interconnected network, we identify pathway commu

148 ional analyses suggested that this 12-mer is highly labile and that apparent on-MHC trimming rates ar

149 The impact of these highly lipophilic sensors has, however, been limited due

150 Ability of highly lithiated phase of Li(7) Ti(5) O(12) for Deep Neu

151 ich are currently unascertained in gnomAD-as highly LoF intolerant or not.

152 The Protein-Probe method is based on highly luminescent europium chelate-conjugated probe, wh

153 The sp(2) carbon frameworks are highly luminescent even in the solid state and exhibit t

154 ch to treat cancer, however, its efficacy in highly malignant brain-tumors, glioblastomas (GBM), is l

155 Medulloblastoma (MB) is a highly malignant cerebellar tumor predominantly diagnose

156 Cholangiocarcinoma (CCA) is a highly malignant epithelial tumor of the biliary tree wi

157 Trabecular meshwork (TM) is a highly mechanosensitive tissue in the eye that regulates

158 tion is a unique biological process by which highly mineralized tissues emerge into the outer world,

159 In fact, only 12% of GLUT1 resolved into a highly mobile subpopulation.

160 In highly modified landscapes, spatial nutrient transport t

161 and directly visualize DNA lesion search by highly motile ATL and ATL-UvrA complexes on DNA at the m

162 ed probability estimates for these typically highly multiclass classification tasks are still lacking

163 NHEJ has the potential to be highly mutagenic because it uses DNA polymerases, nuclea

164 Highly negative experiences would result if these aspect

165 ate that this strategy can be used to create highly nonlinear single-molecule circuits.

166 Using a highly novel gene therapy approach in a canine, rapid at

167 demonstrate that the plasticity rules depend highly on three factors: (1) the location of the input w

168 ond formations were found to proceed through highly ordered cyclic or bicyclic transition states, lea

169 ide nanotubes was applied in the assembly of highly ordered two-dimensional droplet networks.

170 s the ability of epithelial cells to possess highly organized defense machineries, which can jointly

171 ture hiPSC-CMs showed rod-shaped morphology, highly organized sarcomeres, elevated cTnI expression an

172 on from ethanol resulted in a network with a highly organized, porous structure of increased ductilit

173 , internalizing, thought disorder) exhibited highly overlapping patterns of reduced global and widely

174 feeding behaviors, namely overconsumption of highly palatable food (HPF), that may drive obesity.

175 Highly pathogenic avian influenza (HPAI) viruses of the

176 ease complement deposition on the relatively highly pathogenic strain MNZ41.

177 e hypothesise that the parallel emergence of highly-pathogenic AIV may be facilitated by permissive o

178 Psychotic illness in this highly penetrant deletion was associated with similar ne

179 d ASD and elucidate mechanisms through which highly penetrant, multigene copy number variants contrib

180 y and high permeability, as well as a set of highly permeable consensus sequences.

181 at Syrian hamsters, in contrast to mice, are highly permissive to SARS-CoV-2 and develop bronchopneum

182 cells, leading to populations enriched with highly plastic hybrid epithelial/mesenchymal cells, whic

183 We demonstrate that phosphine oxides are highly polar functional groups leading to high solubilit

184 AMOT130 is highly polarized and present only at the apical side of

185 chromophore archetype, FeNHCPZn, features a highly polarized CT state having a profoundly extended (

186 perience; induced CCL1 production identifies highly polyfunctional CD8(+) and CD4(+)T(M) subsets; lon

187 ltiple light scattering events, enabled by a highly porous (>99.99%) non-absorbing nanoarchitecture,

188 BMP15 residues into latent GDF9 generated a highly potent growth factor, called hereafter Super-GDF9

189 Conclusion: PSMA PET results are highly predictive of FFP at 3 y in men undergoing sRT fo

190 meets all seven criteria and demonstrates a highly predictive skill against our test datasets.

191 Overall, IgE sensitization to extracts was highly prevalent (43%-73%) but allergen arrays indicated

192 omyalgia, and neuropathic pain disorders, is highly prevalent but remains poorly treated.

193 Allele (A) was highly prevalent in CRC tissues represented 0.56 (P < 0.

194 V-vectored vaccines might invade despite the highly prevalent wild-type virus.

195 that coagulase-negative staphylococci are a highly prominent infectious agent in peritonitis, and su

196 ts using topical corticosteroids in mice are highly promising for recovery of spirochetes, further op

197 d triplet-triplet annihilation represent two highly promising ways of increasing the efficiency of ph

198 ly the coordination structure of Ni, remains highly puzzling, as previous density functional theory (

199 fast, irreversible labeling species that are highly reactive and footprint broadly several amino acid

200 harsh conditions, highly active catalysts or highly reactive bonding groups, as is done in classical

201 packed bed flow reactor capable of achieving highly regio- and stereoselective C-H functionalization

202 Mitochondrial fission and fusion are highly regulated by energy demand and physiological cond

203 chondrial metabolism and gene expression are highly regulated to accommodate these environmental chan

204 Placental immune responses are highly regulated to strike a balance between protection

205 io) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigat

206 L18R(+) Tregs with molecular characteristics highly reminiscent of tissue-resident effector Tregs.

207 a threshold of 25% of SUV(max) (SUV(25)) was highly reproducible (<9% variability).

208 A highly reproducible finding in CMV-seropositive individu

209 roadly neutralizing antibody VRC01-N using a highly reproducible humanized mouse model.

210 All biometry devices delivered highly reproducible measurements, and most comparative s

211 Our microfluidic technology enabled highly reproducible production of multicomponent eHNPs i

212 In this study, we analyzed highly resolved spatial variables in cities, together wi

213 untimes and performance of the different C++ highly reusable coalescence mergers (binary, multiple, h

214 More importantly, this novel approach is highly scalable and could be approximately >1000 times f

215 The frequency of highly selected gut-associated germinal centres is marke

216 al calcium uniporter complex in metazoans, a highly selective and tightly controlled Ca(2+) channel o

217 on BTK inhibitor, with zanubrutinib, a novel highly selective BTK inhibitor, in patients with WM.

218 g materials have recently been identified as highly selective catalysts for the oxidative dehydrogena

219 on nitride, have recently been identified as highly selective catalysts for the oxidative dehydrogena

220 s C5-modified sialosides, through the use of highly selective enzyme cascades.

221 icles show that these main-group cations are highly selective for the fluoride anion, which is transp

222 ined results allowed the identification of a highly selective G-quadruplex ligand that, when studied

223 les of GSK789, a potent, cell-permeable, and highly selective inhibitor of the first bromodomains of

224 EGF overexpression culminating in extensive, highly selective loss of DG GCs (thereby also reinforcin

225 ote the development of robust, efficient and highly selective LRSPR based biosensors with SiO(2) as t

226 ional analysis of VirChR1 shows that it is a highly selective, Na(+)/K(+)-conducting channel and, in

227 lability led to the discovery of the potent, highly selective, orally available ATR inhibitor BAY 189

228 e interaction), between F(-) and MOF host, a highly selective, sensitive, and reliable fluoride senso

229 The obtained experimental data demonstrate a highly sensitive and reliable detection of ultra-low con

230 ouse liver tissue samples, demonstrating its highly sensitive and specific glycoproteomics and phosph

231 gs, amyloid PET, (18)F-FDG PET, and MRI were highly sensitive for neuropathologic AD.

232 ticles (NPs), thus making them detectable by highly sensitive inductively coupled plasma mass spectro

233 Highly sensitive laser light scattering observations hav

234 pt technique shows significant potential for highly sensitive quantitative detection of multiplex car

235 communities and related carbon dynamics are highly sensitive to changes in climate.

236 , the probe turned out to be unprecedentedly highly sensitive to even subtle differences in the induc

237 tically significant Rt changes, inference is highly sensitive to the function choice.

238 In contrast, we find that Rca activity is highly sensitive to truncations and mutations in the con

239 Here, we present a highly sensitive, rapid and multiplexed protocol termed

240 Four highly sensitized (calculated panel reactive antibody [c

241 show that only females and not males show a highly significant correlation between an increase in TA

242 re increasingly marginal for production, but highly significant for wildlife, and suggest that such t

243 developed a final multivariate model with a highly significant relationship to UOC (Receiver operati

244 e remarkable functional specificities of two highly similar CDC42 splice variants in regulating disti

245 flanking regions of SLF genes, resulting in highly similar flanking regions between different types

246 epresentational dissimilarity for unexpected highly similar foils in DG and CA3.

247 protein sequences and folding structures are highly similar, these StBiPs are distinguishable by thei

248 itical solution temperature (LCST), they are highly soluble.

249 nd would provide a new approach to construct highly sophisticated supramolecular architectures.

250 Tanycytes are highly specialized ependymal cells that line the bottom

251 logists and historians, to have maintained a highly specialized horse-facilitated form of mobile past

252 s are especially powerful when deconvoluting highly specialized microenvironments, such as stem cell

253 e susceptible and resistant interactions are highly specific and that novel and stably inherited meth

254 DVR that form the core of a dense network of highly specific connections between this region and othe

255 sensor was then engineered with a novel and highly specific peptide nucleic acid (PNA) as the recogn

256 of a rapid, sensitive, robust, reliable, and highly specific reverse transcription-RPA technique coup

257 ete set of cation derivatives is to discover highly stable cations, which are further integrated to c

258 evertheless, we still lack an economical and highly stable chitinase enzyme for use in the industrial

259 -mode MCF cores, and that these patterns are highly stable to fibre movement.

260 Of note, glucocorticoids highly stimulated macrophage mobility; unexpectedly, DPP

261 ioselective strategy for the construction of highly strained spiro[2,3]hexane skeletons from methylen

262 ey intermolecular contacts and was otherwise highly structurally heterogeneous.

263 bout their evolutionary adaptations to these highly structured but heterogeneous environments.

264 The highly structured differential cross sections directly r

265 While knowledge of highly structured regions is integral for mechanistic in

266 cleophiles to provide access to a variety of highly substituted pyridines.

267 Evidence was graded as convincing, highly suggestive, suggestive, weak, or nonsignificant.

268 in a particular host is not common except in highly susceptible life-stages, and that single infectio

269 ntly, mice lacking Ly6e in immune cells were highly susceptible to a murine CoV-mouse hepatitis virus

270 peptides on the surface of CpCP3, which was highly susceptible to digestive enzymes and did not alte

271 However, CD163(-/-) mice are highly susceptible to S aureus infections, demonstrating

272 ith more than 250 species, many of which are highly threatened due to overexploitation for their rose

273 all and soluble prefibrillar aggregates, are highly toxic due to their strong ability to seed tau mis

274 limits to-date for many compounds, including highly toxic iodinated, brominated, and nitrogen-contain

275 have synthesized 11 trisaccharides that are highly tunable in structure and sulfation pattern, allow

276 cted 331,696 Twitter posts referencing 1,800 highly tweeted bioRxiv preprints and leveraged topic mod

277 Due to the strongly donating and highly twisted nature of the TTAC donor as well as the s

278 The triconodontid molar series was highly uniform and adapted to a precise fit, with self-s

279 mitochondrial intermembrane space, making it highly unlikely that mHTT interacts with TIM23 and inhib

280 can be used as a promising way of protecting highly unsaturated oils such as FO against oxidation.

281 ood branch of life, including species with a highly unusual body plan and a range of unique adaptatio

282 during the S phase when their expression is highly upregulated.

283 ses in tooth extraction, a procedure that is highly used by publicly insured or uninsured patients.

284 We suggest that tool-using NC crows offer highly useful data for current debates over the necessar

285 uence searches, yet, such a feature would be highly useful to investigators.

286 A highly validated CSC model (FGbeta(3) cells) was used to

287 eaf area and vegetation stress intensity was highly variable among models.

288 e drugs is largely hampered by their low and highly variable bioavailabilities.

289 ainties surrounding the pathogenesis and the highly variable clinical presentation.

290 evelop a mathematical model to show, that in highly variable environments, not only does sensing prom

291 We confirmed highly variable estimates within risk groups, necessitat

292 of field samples that showed persistent but highly variable frequencies of aphid clones containing p

293 seasonal precipitation variation in already highly variable precipitation regimes gives rise to a pa

294 cts on SI variability and whether those with highly variable SI respond to stressful events with incr

295 commercially available serologic assays are highly variable, differing in their format, the antibody

296 glucorticoids (GC) for vocal fold injury is highly variable.

297 sults suggest that even in endemic settings, highly virulent clones can rapidly emerge demanding cons

298 g column demonstrated a kinetic control with highly viscous FIL/ILs, revealing higher performance dif

299 The membrane is also highly vulnerable to many types of perturbation, includi

300 G6PD deficiency makes red cells highly vulnerable to oxidative damage, and therefore sus