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1 inant in proliferating cells where mTORC1 is highly active.
2 ced solid tumours for which larotrectinib is highly active.
5 ary, preclinical studies show SGN-CD19B is a highly active ADC, which releases a DNA cross-linking ag
10 thoxybenzene, and a sulfonamide isostere, is highly active against laboratory and primary clinical HI
11 leaning" function as it has been shown to be highly active against modified cytidine triphosphates, s
14 ugh the newer antiretroviral (ARV) drugs are highly active against the human immunodeficiency virus (
15 mutant-selective irreversible inhibitors are highly active against the T790M mutant, but their effica
17 ipyridylarylmethane ligand was found to give highly active alkane borylation catalysts that facilitat
18 bacterium tuberculosis, while 9b and 9c were highly active also against multidrug-resistant clinical
20 cover five orthogonal pairs, including three highly active amber suppressors, and evolve new amino ac
21 vide a novel platform for the development of highly active and affordable base metal catalysts for th
23 nteraction with Ce-doped hydroxyapatite, are highly active and coke-resistant catalytic sites for DRM
26 approaches are needed for the development of highly active and durable CMFCs that are capable of repl
27 ns, drives the development of simultaneously highly active and durable platinum group metal-free (PGM
30 ther with a suitable Pd-source resulted in a highly active and enantioselective catalyst system for t
31 ) ligands were recently discovered to afford highly active and enantioselective palladium catalysts f
32 ene)][BAr(F) (4) ] derivatives, proved to be highly active and enantioselective precatalysts for asym
33 complete response, suggesting that this is a highly active and feasible combination in children and a
34 c patients, the risk of SCD was increased in highly active and inactive patients compared with active
35 r revealed that the -505/+62 region was both highly active and influenced by GNA13, and a single NF-k
36 ts physiological transporter GBIHBP1 that is highly active and largely resistant to physiological inh
39 of AlMe3/B(C6F5)3/[Ph3C][B(C6F5)4] yields a highly active and productive catalyst system for the con
40 eing coordinated with iron centers to afford highly active and reusable single-site solid catalysts f
41 lding units of a Zr-MOF with Me2Mg affords a highly active and reusable solid catalyst for hydroborat
42 ollowed by treatment with NaBEt3H afforded a highly active and reusable solid Zr12-TPDC-Co catalyst f
44 ates a balanced Lewis acid-base pair for the highly active and selective cascade ethanol-to-isobutene
47 saturated M(III)H centers in M(III)H-BTC are highly active and selective for 1,4-dearomative hydrobor
48 ter, these bis(diazaphospholane) ligands are highly active and selective in asymmetric hydroformylati
50 sed approaches have been developed to design highly active and selective protease substrates and prob
51 ch that make it a useful tool for developing highly active and selective reagents for a wide variety
52 phylococcus aureus Cas9 guide RNAs that were highly active and specific to the human CEP290 target se
55 hange membrane fuel cells (PEMFCs) relies on highly active and stable electrocatalysts for oxygen red
56 ructure design and sequential synthesis of a highly active and stable hydrogen evolution electrocatal
57 developed a novel purification protocol for highly active and stable mitochondrial complex I using t
59 inetic measurements show this catalyst to be highly active and stable under realistic reaction condit
60 terization of electron-transfer processes at highly active and well-defined catalytic sites on a ligh
61 This work opens doors for the preparation of highly active and well-structured nano-mesoporous alumin
62 N4 sites are structurally reminiscent of the highly active and widely studied non-platinum group meta
63 modelling, we show that the dislocations are highly active, and we delineate the specific atomic-scal
65 nts are suitable hosts for the generation of highly active anti-HIV-1 antibodies with the potential t
66 rption using natural red blood membrane, the highly active antibody-toxin interaction enables the nan
67 ant end point for accelerated development of highly active anticancer therapies, yet its relationship
68 pression-based virtual screening to identify highly active antileukemic drugs that synergize with NOT
69 ether people living with HIV (PLHIV) ever on highly active antiretroviral therapy (ART) follow a patt
71 udy was to determine if patients with HIV on highly active antiretroviral therapy (HAART) had any dif
74 ple have decreased since the introduction of highly active antiretroviral therapy (HAART) in 1996.
76 e of brain biopsy in HIV patients in the pre-highly active antiretroviral therapy (HAART) versus post
78 The standard of care for HIV-1 infection, highly active antiretroviral therapy (HAART), combines t
80 HIV-positive persons, both with and without highly active antiretroviral therapy (HAART), methods ha
83 ines in Re coincide with the introduction of highly active antiretroviral therapy and the scale-up of
84 ency virus (HIV)-infected children receiving highly active antiretroviral therapy following immune re
87 y, lipodystrophy, acquired from the standard highly active antiretroviral therapy used to treat AIDS
88 may negatively affect patients' adherence to highly active antiretroviral therapy, psychological heal
91 viral inhibition and CD4 T cell recovery by highly active antiretroviral treatment (HAART), HIV-1 is
93 association of HIV-related exposures (ART or highly active ART [HAART], HIV-RNA plasma viral load [PV
94 ported the association of combination ART or highly active ART use with the following outcomes: high-
97 tionally, CelA is extremely thermostable and highly active at elevated temperatures, unlike commercia
98 inant Burkholderia thailandensis DNase II is highly active at low pH in the absence of divalent metal
99 tudies demonstrated that the Mgp promoter is highly active at the cranial sutures, cranial base synch
101 h protein arrays identify MS patients with a highly active B cell population with antibodies directed
102 is a self-sufficient flavohemeprotein and a highly active bacterial enzyme capable of fatty acid hyd
106 ecent technological improvements, namely two highly active biotin ligase variants (TurboID and miniTu
108 ler density of active sites if compared with highly active bulk MoB2 (which contains only the more ac
109 s of epitope-deleting mutations and produced highly active but aggressively deimmunized constructs in
112 w PNN-pincer ruthenium(0)-imine complex is a highly active catalyst for ester hydrogenation at room t
113 the phosphorus, as a new ligand that forms a highly active catalyst for hydroboration of unactivated
114 enclosed inside a nickel-based MOF act as a highly active catalyst for the Guerbet reaction of ethan
116 s is critical to the rational development of highly active catalyst platforms, experimental data are
118 lorination reaction conditions and show that highly active catalysts comprise single-site cationic Au
120 activated with alkyl aluminum reagents, form highly active catalysts for the polymerization of ethyle
121 se of Pt nanoparticle-decorated nanotubes as highly active catalysts for the reduction of 2,4,6-trini
122 hiral biphenol-type ligands were found to be highly active catalysts in the asymmetric reduction of h
124 s finding provides new insight for designing highly active catalysts with stable superoxo-like/peroxo
129 aving animals, but how the activity of these highly active cells contributes to the mnemonic function
131 ir extracellular gates to ATP occupancy, and highly active CFTR channels that bypass defects in ATP b
132 convert the heat shock protein Hsp33 into a highly active chaperone holdase that binds unfolded prot
133 that the monomers formed upon reduction are highly active chaperones in vitro, but are susceptible t
134 iflimide (Tf2NH) in CH2Cl2 solution leads to highly active chiral Lewis acids that are very effective
135 he identification of compound 9 (OATD-01), a highly active CHIT1 inhibitor with both an excellent PK
137 signment of these newly observed features to highly active Co(4+) centers under catalytic conditions.
138 l-like surface promotes the formation of the highly active Co(Fe)OOH phase, which enhances the OER el
139 en evolution catalysts and, here, we study a highly active Co3O4/Co(OH)2 biphasic electrocatalyst on
140 panel of cancer cell lines and, for selected highly active compounds, interaction with tubulin, cell
141 f the protein scaffold to populate a narrow, highly active conformational ensemble and accelerate thi
142 measured Michaelis-Menten kinetics on these highly active constructs, revealing that the remaining b
144 activation, facilitating the use of compact, highly active CRISPR libraries for single-cell screens.
147 zyme with the Ser-His-Asp catalytic triad, a highly active cysteine-lipase having a Cys-His-Asp catal
148 for reticular design of highly efficient and highly active D-A systems for solar energy harvesting an
150 ted Cmr-alpha binary complex functioned as a highly active DNase to destroy a large excess DNA substr
151 potent AMCase inhibitors, led us to discover highly active dual (i.e., AMCase and CHIT1) inhibitors w
156 The brain's default mode network (DMN) is highly active during wakeful rest when people are not ov
160 one of the simplest strategies for preparing highly active electrocatalysts and is very flexible for
162 stems benefit from the efficient wiring of a highly active enzyme pair and allow for the reversible c
163 phocytic leukemia, where it has proven to be highly active, even in patients with high-risk del(17p)
165 adaptable networks (CANs) often make use of highly active external catalysts to provide swift exchan
166 Pyrolysis is indispensable for synthesizing highly active Fe-N-C catalysts for the oxygen reduction
167 rane preparations of A. fermentans contain a highly active ferredoxin/flavodoxin-NAD(+) reductase (Rn
170 infection, the present study developed novel highly active food-grade antimicrobial peptides affectin
173 njugated rhenium (GCC-Re) catalysts that are highly active for CO2 reduction to CO in acetonitrile el
175 is stable under an atmosphere of N(2) and is highly active for hydrogen isotope exchange at (hetero)a
176 Notably, longer oligomers are found to be highly active for nonlinear absorption and emission prop
177 lysts containing dative nitrogen ligands are highly active for the borylation and silylation of C-H b
179 s it from an inert material into one that is highly active for the hydrogen evolution reaction (HER).
180 emistry from a mesityl complex [Cu5Mes5] are highly active for the hydrogenation of a broad range of
181 re we show metal/oxide interfacial sites are highly active for the oxidation of benzyl alcohol and ot
183 This area of immunological research has been highly active for the past 50 years and is now enjoying
185 dppb = 1,4-bis(diphenylphosphino)butane) are highly active for the transfer hydrogenation of ketones
186 facile experimental approach to isolation of highly active functional RNAs from low-diversity populat
188 This includes reduced expression of the highly active glycine-n-methyltransferase and the biliar
191 ational preparation of heterostructures with highly active heterosurfaces remains a challenge because
192 neurons, the existence of donor L1s that are highly active ('hot') in specific spatiotemporal niches,
194 s, containing a B26-B29 triazole bridge, was highly active in binding to both IR isoforms, with a sig
195 nd 2 studies, ceritinib has been shown to be highly active in both ALK inhibitor-naive and ALK inhibi
197 ng mediated by NFkB-inducing kinase (NIK) is highly active in intestinal lymphoid follicles, and is r
199 5 (Cdk5), a serine-threonine kinase that is highly active in postmitotic neurons and in many cancers
200 zing the anti-apoptotic function of Bcl-2 is highly active in preclinical models of refractory acute
205 simple and effective approach for producing highly active in situ catalysts on a carbon support for
210 ndeed, an inhibitor of Bcl2, venetoclcax, is highly active in the treatment of patients with CLL.
214 Here, we develop CD229 CAR T cells that are highly active in vitro and in vivo against MM plasma cel
215 lpha, HK2 and glycolytic metabolism was also highly active in vivo as demonstrated by fluorodeoxygluc
218 for electrocatalytic water oxidation on the highly active iron(Fe)-doped beta-nickel oxyhydroxide (b
222 inishing the l-glutaminase activity of these highly active l-asparaginases, our engineered ErA varian
223 imetallic mixtures revealed the formation of highly active lithium diorganodialkoxyzincates of type [
225 Adipose tissue has been recognized as a highly active metabolic and endocrine organ, secreting a
227 eorgeite, which we find to be a precursor to highly active methanol-synthesis and superior LTS cataly
228 s, decreased glutathione redox capacity, and highly active mitochondria with increased vulnerability
229 Selection under conditions that resolve highly active mutants reveals that 23.3% of all single p
231 normal distribution, with a small portion of highly active neurons (termed Primed Neurons) filling th
234 hat enables the large scale proliferation of highly active NK cells in support of large scale third p
236 The piggyBac (PB) transposon system is a highly active non-viral gene delivery system capable of
237 te that a novel nitride, Ni(2) Mo(3) N, is a highly active OER catalyst that outperforms the benchmar
240 that were active in C deamination were also highly active on methylated C (mC), with hap II displayi
241 ein, we describe the marriage of tunable and highly active organic catalysts with programmed continuo
242 The polymers are synthesized using a new, highly active organometallic heterodinuclear Zn(II)/Mg(I
243 rication of novel platinum-group-metals-free highly active ORR electrocatalysts in alkaline media.
244 However, progress in the development of highly active oxide nanostructures is hampered by a lack
246 rward renewable energy technology to develop highly active oxygen evolution reaction (OER) catalysts
249 ), increased risk for SCD was encountered in highly active patients (hazard ratio, 7.46 [95% CI, 2.32
255 e presence of LIF occupy a ground state with highly active pluripotency-associated transcriptional an
259 ind that Chlorobi-affiliated bacteria may be highly active protein degraders, catabolizing extracellu
262 g on nucleoside analogs to capitalize on the highly active salvage pathways of Leishmania, which are
264 Dmt = 2',6'-dimethyltyrosine) resulted in a highly active, selective MOR antagonist, c[-d-Arg-Phe-Ly
265 oparticles embedded in the capsule walls are highly active, selective, and recyclable catalysts for t
267 e mutation plus a cytosolic GOF mutation was highly active (single-channel open probability >0.3) in
268 In summary, helenalin acetate is the first highly active small-molecule C/EBPbeta inhibitor that in
270 uel cells also requires a WGS catalyst to be highly active, stable, and energy-efficient and to match
271 l application of FeS(2)/C nanocomposite as a highly active, stable, and recyclable catalyst for heter
273 um between a predominant inactive and a rare highly active state that mediates bleaching adaptation i
274 eus undergoes programmed transformation from highly active status, associated with execution of the g
276 (SL) in root exudates from 5-deoxystrigol, a highly active Striga germination stimulant, to orobancho
278 functional impairment which was supported by highly active suppressive mechanisms established within
279 theory calculations suggest the formation of highly active surface layers during strontium leaching w
280 s relies on the design of architectures with highly active surfaces and optimized utilization of the
281 -1) is very close to the reported values for highly active synthetic models of compound I of cytochro
282 d the nucleoplasm, sandwiched in between two highly active systems inside the cell: cytoskeleton and
283 loyed are limiting broader implementation of highly active tailor-made arylborane Lewis acids and Lew
286 hting the utility of our approach to develop highly active therapeutic leads purely based on computat
287 2)-supported rhodium catalyst is found to be highly active, this is not the case for MgO, most likely
288 lfanyl, and 6-methyl derivatives, which were highly active to cancer cells and less toxic or nontoxic
293 is of density functional studies that reveal highly active under-coordinated cobalt atoms in the clus
294 cumulate and/or deplete a diverse variety of highly active, unstable or stable target proteins in dif
296 er describes an optimization strategy of the highly active vinyl ketone 3 which was recognized as a s
298 l-CoA specificities: two DGAT2 isoforms were highly active with 22:1-CoA, while the ability of the ot
299 e activity with SAC; however, the enzyme was highly active with l-cysteine, N-acetyl-l-cysteine, and