ライフサイエンスコーパス: highly divergent

1 ini, often called the cytoplasmic tails, are highly divergent.

2 ng mechanisms that mediate taste in each are highly divergent.

3 Y formed a unique clade, suggesting that are highly divergent.

4 M-7 homologs are found only in fungi and are highly divergent.

5 gous to ENaC, but a key functional domain is highly divergent.

6 Hence cell wall regulatory pathways may be highly divergent.

7 olyether antibiotics, which are structurally highly divergent.

8 nsists of genetic loci with alleles that are highly divergent (15.1 megabases of the total genome siz

9 S. invicta contains a highly divergent 17-member OBP gene family, that include

10 e Helkesimastix in a strongly supported, but highly divergent 18S sister clade.

11 Phylogenetic analyses reveal Homotherium as highly divergent (~22.5 Ma) from living cat species, wit

12 first genome wide integration profile of the highly divergent AAV-5 serotype.

13 Two ancient and highly divergent actin-based cytoskeletal systems have e

14 ly occurring enzyme homologues often display highly divergent activity with non-natural substrates.

15 ical traits, suggesting that the ILs contain highly divergent allelic variation.

16 d from a different germ-line gene encoding a highly divergent amino acid sequence.

17 idating these principles because it has many highly divergent amino acid sequences that are <20% iden

18 0 amino acids (aa) is flanked in all FGFs by highly divergent amino-terminal and carboxy-terminal seq

19 among eukaryotes, but surprisingly, ISG15 is highly divergent among animals.

20 The mechanism for TER 3'-end processing is highly divergent among different organisms.

21 This region is highly divergent among different Wee1 proteins, consiste

22 the intergenic regions of the Q/q locus are highly divergent among homoeologous genomes.

23 protein is well-conserved across taxa, TR is highly divergent amongst distinct groups of species.

24 To make sense of highly divergent anatomies requires a hierarchical view

25 ns and appearing organism-specific, may have highly divergent and cryptic orthologs in other species.

26 The CaPIMT2 gene is found to be highly divergent and encodes two possible isoforms (CaPI

27 ssociated with the heterochromatic knobs are highly divergent and heavily methylated compared with th

28 uncinata lineages are able to maintain both highly divergent and highly conserved genes within a rap

29 Unfortunately, many protein families are highly divergent and not suitable for sequence-based rec

30 ell conserved between most organisms, TER is highly divergent and thus difficult to identify.

31 mong eukaryotic eIF4G proteins in that it is highly divergent and unusually small in size, raising th

32 eIFiso4G, one of two isoforms in plants, is highly divergent and unusually small in size.

33 One strain was highly divergent and was designated as the HTLV-4 subtyp

34 Telomerase RNA subunits are phylogenetically highly divergent, and different strategies have evolved

35 However, the Fip1 sequence is highly divergent, and residues on both Pap1 and Fip1 at

36 ssion of these effector molecules is however highly divergent, and tools that identify and preselect

37 This strategy yielded highly divergent antigenic footprints that do not exist

38 A highly divergent approach for the synthesis of metal-bin

39 ans-spliced, and its protein genes, although highly divergent, are evolving under various degrees of

40 to show that alternate supergene alleles are highly divergent at over 1,000 genes and that these alle

41 Despite being highly divergent at the amino acid level, IFITM3 protein

42 Although highly divergent at the primary sequence level, an atomi

43 Although these domains are highly divergent at the primary sequence level, the stru

44 observed to several core ATG genes, such as highly divergent ATG8 paralogs in dermatophytes and mult

45 Through their highly divergent axons, inhibitory neurons indiscriminat

46 immune responses that are protective against highly divergent B. bronchiseptica strains, preventing c

47 , but the U and G forms predominantly harbor highly divergent bacterial lineages belonging to two dif

48 development to all antibiotics tested across highly divergent bacterial species.

49 tification and characterization of distinct, highly divergent bacteriophage families.

50 odern human Y chromosomes-including A00, the highly divergent basal haplogroup.

51 Guided by synteny, we identified a highly divergent basalin ortholog in the related Leishma

52 rches for the BBI inhibitory loop discovered highly divergent BBI-like sequences in the seedless, vas

53 bilize an intermolecular beta-sheet around a highly divergent beta-strand of the BTB domain.

54 epeat- and transposon-associated siRNAs were highly divergent between A. thaliana and A. arenosa.

55 hibition are encoded by a small exon that is highly divergent between ankyrin family members but cons

56 g B lineage specification and commitment was highly divergent between B-1 and B-2 progenitors.

57 Stl proteins are highly divergent between different SaPIs and respond to

58 we identified 57 protein sequences that are highly divergent between East Asian and non-Asian strain

59 larly, melanism of the central primaries was highly divergent between L. argentatus and L. cachinnans

60 tween 100 and 300 amino acids in length, are highly divergent between organisms, and are resistant to

61 hese results suggest that DNA methylation is highly divergent between populations, and that this dive

62 more meagerly expressed in females, and more highly divergent between species.

63 king in Saccharomyces cerevisiae, identified highly divergent box C'/D' motifs that are bound by snoR

64 rference are shared between S. pombe and the highly divergent budding yeast Saccharomyces cerevisiae

65 l bunyavirid group suggests that ancient and highly divergent bunyavirid lineages remain undetected i

66 Most P450 families are highly divergent, but in contrast the cytochrome P450 14

67 in the interaction with the ECF module and a highly divergent C-terminal domain that binds the substr

68 laminin-332 beta3 chain provide distinct and highly divergent cell adhesion and tumor-promoting funct

69 Remarkably, the highly divergent channel possesses similar features as h

70 We found a highly divergent circovirus in serum samples from severa

71 We found that B. suis is a highly divergent clade with extensive intraspecific gene

72 We show that X-cells group in two highly divergent clades, robustly sister to the bivalve

73 The cytochrome P450s (CYPs) represent a highly divergent class of enzymes involved in the oxidat

74 Highly divergent co-existing strain variants emerge duri

75 ifferences relative to strain R, including a highly divergent complement of vlhA surface lipoprotein

76 to a broad spectrum of complex inhibitors of highly divergent composition including humic acid, bone

77 tems, and the carbocyclic diastereomers have highly divergent conformational profiles.

78 Finally, in a challenging circuit with highly divergent connections, BAcTrace correctly identif

79 Overall, the highly divergent contents of FP and EFP indicate that th

80 A highly divergent coronavirus, tentatively named coronavi

81 we found that trigenic interactions in this highly divergent cross were substantially more frequent

82 Cyclophilin38 (CYP38) is one of the highly divergent cyclophilins from Arabidopsis thaliana.

83 12, and have now investigated three further highly divergent, cystoviral P4 NTPases (from 6, 8 and 1

84 h ancestral neurogenesis mode prefigures the highly divergent cytoarchitectures that are seen in exta

85 ilies listed in the SCOPPI database and from highly divergent cytokine families.

86 A highly divergent de novo asymmetric synthesis of benzyl

87 gramma, two closely related sea urchins with highly divergent developmental gene expression and life

88 study focuses on the dorsal ectoderm in two highly divergent dipterans, the fruitfly Drosophila mela

89 r discovery and de novo assembly of a novel, highly divergent DNA virus at the interface between the

90 for cell size control in this important and highly divergent domain of life.

91 gue (C domain), we also identified a second, highly divergent E1 superfamily member, annotated as an

92 he predictable migratory patterns and use of highly divergent ecosystems shown by male tiger sharks a

93 data show that dietary n-3 DPA and EPA have highly divergent effects on human lipid mediator profile

94 irically designed shRNA constructs exhibited highly divergent efficiencies in mediating EGFR knockdow

95 while simultaneously enabling collimation of highly divergent emission for far-field accumulation.

96 ern, central, and eastern ancestries, plus a highly divergent Ethiopian population.

97 r, these studies provide insights into how a highly divergent eukaryote has re-wired protein N-glycos

98 inucleate pathogen Giardia intestinalis is a highly divergent eukaryote with a semiopen mitosis, lack

99 me of the trypanosome NPC, a representative, highly divergent eukaryote.

100 As evolutionarily highly divergent eukaryotes, the organisation and conser

101 ch longevity genes are conserved between two highly divergent eukaryotic species, the yeast Saccharom

102 rfectly conserved among eukaryotes, ISG15 is highly divergent, even among mammals.

103 chanisms of plants and animals despite their highly divergent evolutionary paths.

104 fy the hypothetical Mtb protein Rv2179c as a highly divergent exoribonuclease.

105 ylogenetic search and uncovered more than 35 highly divergent families of actin-like proteins (Alps)

106 ifying radical SAM enzymes associated with a highly divergent family of peptides in which the only cl

107 lts from our computational case study of the highly divergent family of retroelements accord with pre

108 alization and in vivo protection against two highly divergent filovirus species, i.e., Ebola virus an

109 These haplotypes are highly divergent, frequently associated with structural

110 Detecting genetic variants that are highly divergent from a reference sequence remains a maj

111 elated Aequorea species, with most sequences highly divergent from A. victoria green fluorescent prot

112 A) gene encodes a protein that appears to be highly divergent from all known influenza NAs and was as

113 The neuraminidase (NA) gene is highly divergent from all known influenza NAs, and the i

114 Human mitochondrial ribosomes are highly divergent from all other known ribosomes and are

115 s virus, named astrovirus VA1 (AstV-VA1), is highly divergent from all previously described astroviru

116 nd rice, a protein-poor agronomic crop, both highly divergent from Arabidopsis.

117 clearly related to the asfarvirus family but highly divergent from ASFV.

118 of 122 RNA bacteriophage phylotypes that are highly divergent from each other and from previously des

119 strovirus, HAstV-VA1/HMO-C-UK1(a), which was highly divergent from human astrovirus (HAstV 1-8) genot

120 results suggest that Drosophila myosin-18 is highly divergent from most other myosins in the superfam

121 imation may result in FST estimates that are highly divergent from one another.

122 ave numts of the COI gene, many of which are highly divergent from orthologous mtDNA sequences, and D

123 The N-terminal tail of CENP-A is highly divergent from other H3 variants.

124 teristic of the family Polyomaviridae but is highly divergent from other members of this family.

125 The sequence of J3 is highly divergent from previous anti-HIV-1 VHH and its ow

126 in hyperthermophilic archaeal hosts and are highly divergent from RNA viruses that infect eukaryotes

127 The sequences of all of these enzymes are highly divergent from sequences found in other organisms

128 echnical challenge when the novel species is highly divergent from the closest known species.

129 ed SERT phosphorylation site, Thr-276, being highly divergent from the consensus PKG phosphorylation

130 Because C. parvum IMPDH is highly divergent from the host counterpart, selective in

131 to detect unknown phages, some of which are highly divergent from the known phage families.

132 Both variants are highly divergent from the prototype virus and variants i

133 The Boodlea chloroplast genes are highly divergent from their corresponding orthologs, and

134 izing human monoclonal antibodies (MAbs) are highly divergent from their germ line counterparts.

135 The commercial population was genetically highly divergent from wild-caught North American monarch

136 le that is related at the sequence level but highly divergent functionally.

137 series of distinct corepressor variants with highly divergent functions.

138 on resulted in diverse and - in some cases - highly divergent future potential occupancy patterns for

139 Single channel analysis showed highly divergent gating behavior with Hom and WT favorin

140 l other primate hepaciviruses, including the highly divergent GBV-A and GBV-C viruses, are functional

141 Here, we report the discovery of a novel and highly divergent GBV-B-like virus in an Old World monkey

142 proposed to accommodate two newly discovered highly divergent geminiviruses that presently have no kn

143 al genomes, which are compact with fewer and highly divergent genes [8].

144 enome consisting of a family of 4-10 tandem, highly divergent genes encoding pseudokinases that are i

145 rther indicate that about one third of these highly divergent genes, including cagA and vacA, are und

146 her not targeted by the RVP or missed due to highly divergent genome sequences.

147 Phylogenetic analysis placed these highly divergent genomes near the root of the picorna-li

148 ments, and thus is particularly suitable for highly divergent genomes.

149 We show that these two states acquire highly divergent genomic distributions with substantial

150 Parallel phenotypic changes thus masked highly divergent genomic responses to selection, illustr

151 that some soluble gp120s and gp140s exhibit highly divergent glycosylation profiles compared to trim

152 he immunogen elicited bnAbs that neutralized highly divergent group 1 (H1 and H5 subtypes) and 2 (H3

153 r of the amidohydrolase superfamily (AHS), a highly divergent group of enzymes that catalyze primaril

154 ing the same genetic background, but showing highly-divergent growth rates and nutritional status.

155 dbx belongs to the highly divergent H2.0 family of homeobox genes.

156 isolation and partial characterization of a highly divergent hantavirus, named Nova virus (NVAV), fr

157 covered that the genome was characterized by highly divergent haplotypes and showed 10- to 30-fold va

158 Population-genetic analyses identified two highly divergent haplotypes at the glc-1 locus that have

159 were attributable to the segregation of two highly divergent haplotypes, Hbbs (which carries two ide

160 Highly divergent HIV drug resistance profiles were obser

161 Highly-divergent HIV drug resistance profiles were obser

162 haeal biochemistries of NH(3) oxidation is a highly divergent homolog of the ammonia monooxygenase (A

163 onuclease P-can sometimes be replaced with a highly divergent homolog, the cellular response to such

164 e, with improvement being most prominent for highly divergent homologs.

165 Such recognition of highly divergent homologues can be improved by reference

166 If this is true, one might expect highly divergent Hsp70-JDP pairs to be unable to functio

167 The highly divergent HST branch is indicative of greater mtD

168 Surprisingly, the highly divergent human SE domain functions in yeast.

169 The species with highly divergent, hyperossified skulls often have a spec

170 ymbionts, despite their common function, are highly divergent in different hosts.

171 Genes that are highly divergent in East Asian H. pylori strains compare

172 Furthermore, TRIM69 is highly divergent in human populations and exhibits signa

173 The protoflgCK gene organization was highly divergent in relation to other CK genes but share

174 Type II REases are highly divergent in sequence as well as in topology, i.e

175 ding site sequence and a Cro protein that is highly divergent in sequence, dimerization interface and

176 ants, referred to as eIF4G and eIFiso4G, are highly divergent in size, sequence, and domain organizat

177 ssion of gene neighbors in either species is highly divergent in the other, in particular when the ne

178 me was found to contain a second, redundant, highly divergent infC gene which, when deleted, had no e

179 The recent identification of highly divergent influenza A viruses in bats revealed a

180 the breadth of binding and neutralization to highly divergent influenza virus strains and subtypes.

181 owever, it is unknown what, if any, role the highly divergent intracellular N and C termini contribut

182 way while seahorses (Hippocampus) featured a highly divergent invariant chain (CD74).

183 of cytoplasmic actins from humans and even a highly divergent invertebrate Ciona intestinalis qualita

184 Two highly divergent isoforms of eIF4G, known as eIF4G and e

185 to fully elucidate the mechanisms underlying highly divergent LD patterns found in commercial chicken

186 na benthamiana plants were associated with a highly divergent left intergenic region and C4 gene.

187 ents-vimentin intermediate filament (IF) and highly divergent, lens-specific beaded filament (BF)-seq

188 A second, highly divergent lentiviral clade, PLVA, infects mountai

189 are the sole surviving representatives of a highly divergent lineage that arose near the dawn of ant

190 for transmissible strains the coexistence of highly divergent lineages acquired by patient-to-patient

191 es to reveal that their causative agents are highly divergent lineages related to M. mackini (Paramik

192 sloths have a single origin but comprise two highly divergent lineages that are not directly related

193 Four highly divergent lineages were observed, all with signal

194 Moreover, we identify one highly divergent locus in African taurine cattle, which

195 ncestor was unusual in having maintained two highly divergent long-term L1 lineages with different le

196 l positions, providing an explanation of how highly divergent Ly49s that retain the ability to bind c

197 step process, starting from N(tolyl)(3) in a highly divergent manner (7 examples).

198 HTCC5015 is a novel, highly divergent marine member of the Gammaproteobacteri

199 1 is a 'housekeeping' gene, and GmPpcK4 is a highly divergent member, distantly removed from the legu

200 genomes encoding replicase proteins plus two highly divergent members of the Picornavirales order wer

201 f sequence homology-based identification for highly divergent microorganisms is the short length of r

202 hin the angiosperm genus Silene that exhibit highly divergent mitochondrial mutation rates.

203 The approach also predicted highly divergent MoAs for two FDA-approved antihistamine

204 Two new studies show how highly divergent modes of male reproduction in a wading

205 Our work illustrates how highly divergent morphologies can be derived from modifi

206 Combined, these data suggest that this highly divergent motor may function as an actin tetherin

207 hole-genome bisulfite sequencing data on two highly divergent mouse strains to study this problem.

208 ernal domains forming a catalytic core but a highly divergent N terminus.

209 egulation of CSB/ERCC6 despite the otherwise highly divergent nature of the N- and C-terminal regions

210 We identify highly-divergent New World SNPs that coincide with high-

211 nvestigation using a metagenomic approach, a highly divergent novel Human papillomavirus type was ide

212 shown that SM gene clusters are often either highly divergent or uniquely present in one or a handful

213 The trypanosomatids are highly divergent organisms and possess well-documented b

214 Although regeneration competence is found in highly divergent organisms throughout the animal kingdom

215 -domains from three phages representative of highly divergent P22-like homology groups.

216 ependent plasmid incompatibility between the highly divergent Par operons of plasmids pB171 and pCP30

217 cluded from the study due to the presence of highly divergent paralogs or xenologs.

218 Sequences from a highly divergent parvovirus, provisionally called bufavi

219 onserved, numerous peripheral structures are highly divergent, perhaps reflecting requirements to int

220 This clade is characterized by highly divergent physiological strategies, with deciduou

221 f independently evolved lateral organs among highly divergent plant lineages, contributing to the mor

222 sequencing approach, we identified a novel, highly divergent polyomavirus, provisionally named MX po

223 ficity, the functional NKT cell subsets were highly divergent populations with many gene-expression a

224 with related individuals and admixture from highly divergent populations, we demonstrate that REAP g

225 or admixture mapping in hybrid zones between highly divergent populations.

226 thods, and computational studies have led to highly divergent pore models.

227 iven proton pulses, inherently broadband and highly divergent, pose a challenge to established beamli

228 nous retrovirus (ERV) germline integrants in highly divergent, previously unsequenced mouse lineages,

229 transcription and cell viability, but has a highly divergent primary sequence in comparison to TFIIB

230 Initial studies found that despite the highly divergent primary structure of different amyloid-

231 sful fusion between a PKS and NRPS that make highly divergent products, and four previously reported

232 tructurally conserved regions (SCRs) even in highly divergent protein families.

233 Inferring evolutionary relationships among highly divergent protein sequences is a daunting task.

234 First, what evidence supports these highly divergent proteins being true homologues to the p

235 g, ab initio, phylogenetic relationships for highly divergent proteins in a quantifiable and robust m

236 ions increases with genetic distance so that highly divergent proteins may have evolved codependencie

237 dings that suggest the presence of unique or highly divergent proteins that may offer therapeutic opp

238 ntrast to their eukaryotic counterparts, are highly divergent proteins whose wide-ranging functions a

239 process versus outcomes metrics and lead to highly divergent provider rankings.

240 og revealed an NA-like structure, but with a highly divergent putative active site exhibiting little

241 ory CD4 T cells comprise subpopulations with highly divergent rates of turnover, and show that inflow

242 use this same switch locus to generate their highly divergent red and brown color pattern elements.

243 tion across intermediate-sized and sometimes highly divergent repeats.

244 plicate humanized mice generated diverse and highly divergent repertoires.

245 ic-based classification for HCC have yielded highly divergent results, indicating difficulty in ident

246 The highly divergent ribosomes of human mitochondria (mitori

247 (Leptomonas pyrrhocoris ostravirus 1) with a highly divergent RNA-dependent RNA polymerase missed by

248 unction, revealing that these receptors have highly divergent roles in vascular and metabolic homeost

249 A highly divergent route to lipophilic iminosugars that ut

250 In summary, porcine NoVs and highly divergent SaVs were present in North Carolina fin

251 fh), binds the signal peptides, which have a highly divergent sequence divisible into a positively ch

252 at positions 38, 39, and/or 40 of tRNAs with highly divergent sequences and structures through a poor

253 Template switches between highly divergent sequences appear to be mechanistically

254 tail was substituted with the equivalent but highly divergent sequences from Francisella tularensis.

255 und signature of purifying selection only in highly divergent sequences, suggesting that the method y

256 may detect evolutionary relationships among highly divergent sequences.

257 e we report the identification of two novel, highly divergent simian arteriviruses related to SHFV, M

258 rial DNA phylogenies suggested that it was a highly divergent sister lineage to all extant cat specie

259 Highly divergent sites in multiple sequence alignments (

260 f population substructure, we identified 114 highly divergent SNPs as candidates for environmental se

261 This transfer of novel S determinants into a highly divergent species (>140 million years apart) with

262 of temperate and tropical forest plots with highly divergent species pools (46 vs. 607 species).

263 a latitudinal gradient in eastern China with highly divergent species pools.

264 Therefore, particularly when comparing highly divergent species, functional sequences that are

265 nction relationship of these residues across highly divergent species.

266 the conservation of protein function between highly divergent species.

267 en parallel evolution will be observed among highly divergent species.

268 ring neutralizing antibody responses between highly divergent strains suggested that the MNV genogrou

269 ured when genetic mapping is performed using highly divergent strains, and closely similar strains ar

270 bination with xylem vulnerability to produce highly divergent strategies of water management.

271 ory elements mecI/mecR that also have novel, highly divergent structures.

272 ides a straightforward approach for modeling highly divergent subclasses of patients, which may be ad

273 ns, ACT2, ACT7, and ACT8, in two ancient and highly divergent subclasses.

274 A concise and highly divergent synthetic use of 1 was developed, there

275 Previously, we identified a highly divergent T. brucei N-acetylglucosaminyltransfera

276 ra/Tcrd locus is unique because it undergoes highly divergent Tcrd and Tcra recombination programs in

277 he proteins that make up the kinetochore are highly divergent; the inner kinetochore comprises at lea

278 Although these viruses are highly divergent, they share a similar genomic plan and

279 divergence and is depleted in patients with highly divergent TIL repertoires.

280 ng RNA (siRNA) biogenesis at the 3' cleaved, highly divergent transcript regions, generating over 100

281 eing showed similar affective correlates but highly divergent transcriptome profiles.

282 Further, we find the two biomes to have highly divergent tree species compositions and to repres

283 he Holliday junction intermediate of several highly divergent tyrosine recombinases.

284 Trichomonas vaginalis is a highly divergent, unicellular eukaryote of the phylum Me

285 Nursing homes have highly divergent urine culturing rates; this variability

286 ng sequence designs, yielding functional yet highly divergent variants from natural homologs.

287 environments and organisms continue to yield highly divergent viral genomes NCA provides a rapid and

288 The identification of slightly mutated and highly divergent virus genomes has been shown to be most

289 We found that ticks are hosts to highly divergent viruses across several taxa, including

290 frican monkeys and discovered several novel, highly divergent viruses belonging to the family Arteriv

291 ice against lethal influenza challenges with highly divergent viruses.

292 Notch ligand expression are observed in two highly divergent wild C. elegans isolates.

293 n virulence determinants (CagA and VacA) are highly divergent, with 77% and 87% mean amino acid seque

294 The three transcriptomes are highly divergent, with about three-quarters of those gen

295 nterestingly, several other protists possess highly divergent XPB paralogues suggesting that XPBs spe

296 inetoplastid organisms, however, possess two highly divergent XPB paralogues with only the larger bei

297 Finally, another highly divergent yeast RCAN, termed Rcn2 (YOR220w), was

298 es with a copurifying partner termed NupA, a highly divergent yet essential NPC protein.

299 s of cadherins from invertebrates, which are highly divergent yet function in similar roles, remain u

300 ively across the glomerular layer to provide highly divergent yet selective output onto interneurons