ライフサイエンスコーパス: highly metastatic

1 ds to a castration-resistant disease that is highly metastatic.

2 tics of human osteosarcomas, including being highly metastatic.

3 e C-alpha (PKC-alpha), is both malignant and highly metastatic.

4 ablation, chemo- and radiotherapy, but also highly metastatic.

5 strogen unresponsive, fully tumorigenic, and highly metastatic.

6 ARCaP is tumorigenic and highly metastatic.

7 ed as postpartum breast cancer (PPBC) and is highly metastatic.

8 Colorectal cancer (CRC) is highly metastatic.

9 ancers arising from neuroendocrine cells are highly metastatic.

10 PKCdelta levels are increased in highly metastatic 13762NF mammary tumor cells (MTLn3) co

11 In vitro incubation of the highly metastatic 253J B-V cells and the IFN-alpha-resis

12 able to suppress the metastatic phenotype in highly metastatic 4T1 and MDA-MB-231 SCP28 cells, as wel

13 w aspirates and mouse models challenged with highly metastatic 4T1 breast cancer cells, we demonstrat

14 tand the chemoresistance mechanism using the highly metastatic 4T1 breast cancer model, which emulate

15 is associated with doxorubicin resistance of highly metastatic 4T1 breast cancer.

16 py was tested against weakly immunogenic and highly metastatic 4T1 breast tumor using SU6668, an angi

17 y, cleaved caspase-3 decreased by 45% in the highly metastatic 4T1 cells after hypoxia.

18 e nonmetastatic 67NR cells and lowest in the highly metastatic 4T1 cells.

19 C expression by small interfering RNA in the highly metastatic 4T1 mammary tumor cell line expressing

20 erapy strategy in the weakly immunogenic and highly metastatic 4T1 murine mammary cancer model.

21 In the highly metastatic A375-M human melanoma cells, p190-RhoC

22 Transfection of AP-2 into highly metastatic A375SM melanoma cells (AP-2-negative a

23 First, the PLD2 gene was silenced in highly metastatic, aggressive breast cancer cells (MDA-M

24 The highly metastatic amelanotic C8161 human melanoma line w

25 o a transition from androgen-dependence to a highly metastatic and androgen refractory (androgen depl

26 (TN) breast cancers (ER(-)PR(-)HER2(-)) are highly metastatic and associated with poor prognosis.

27 Pancreatic ductal adenocarcinoma is highly metastatic and current preoperative evaluation of

28 Because the disease is highly metastatic and difficult to diagnosis until late

29 programmed cell death protein 1 (anti-PD-1), highly metastatic and fibrotic, and secreted TGFbeta/CXC

30 lectively knock down GnT-V expression in the highly metastatic and invasive human breast carcinoma ce

31 Cells lacking vinculin are highly metastatic and motile.

32 xpressed pluripotency-associated genes, were highly metastatic and showed long-term in vivo tumorigen

33 cer cell lines and selected subpopulation of highly metastatic and tumorigenic cells (ALDH(high)) str

34 hotopic growth and spontaneous metastasis of highly metastatic, androgen-insensitive caveolin-1-secre

35 ane glycoprotein found on the surface of the highly metastatic ascites 13762 rat mammary adenocarcino

36 abundantly expressed on the cell surface of highly metastatic ascites 13762 rat mammary adenocarcino

37 viral Gag-like protein p58gag expressed in a highly metastatic ascites rat mammary adenocarcinoma has

38 f the Mr 85,000 standard form of CD44 in the highly metastatic AT3.1 rat prostatic cells greatly supp

39 containing this region was transferred into highly metastatic AT6.3 rat prostate cancer cells by mic

40 f B16 melanoma and at much reduced levels in highly metastatic B16 variants.

41 that it was substantially down-regulated in highly metastatic B16-F10 melanoma cells, which contribu

42 In the poorly immunogenic, highly metastatic, B16/F10.9 tumor model a dramatic redu

43 d SENP7L levels lessens the dissemination of highly metastatic BCa cells to the lungs from primary im

44 Here, using a highly metastatic breast cancer (4T1) model, we show tha

45 breast carcinoma and on the cell surface of highly metastatic breast cancer cell line MDA-MB-231.

46 re linked to MCT expression in MDA-MB-231, a highly metastatic breast cancer cell line.

47 e show that the loss of KiSS-1 expression in highly metastatic breast cancer cell lines correlates di

48 e 2, I-branching enzyme, is overexpressed in highly metastatic breast cancer cell lines of human and

49 type plasminogen activator, and cytokines in highly metastatic breast cancer cell lines.

50 The restoration of miR-203 in highly metastatic breast cancer cells inhibited tumor ce

51 onditioning of naive mice with exosomes from highly metastatic breast cancer cells revealed the accum

52 These genes are upregulated in highly metastatic breast cancer cells, and their increas

53 verexpression of protein kinase Calpha), and highly metastatic breast cancer cells.

54 miR-203 was significantly down-regulated in highly metastatic breast cancer cells.

55 we found that stable SDPR overexpression in highly metastatic breast cancer model cell lines inhibit

56 on of hyaluronan synthase 2 (HAS2) occurs in highly metastatic breast cancer stem-like cells (CSC) de

57 ve breast cancer (TNBC) is an aggressive and highly metastatic breast cancer subtype.

58 Overexpression of AP-2alpha into highly metastatic breast cell lines did not alter KiSS-1

59 is greater than that in normal tissue, with highly metastatic breast epithelial cells expressing the

60 Furthermore, blockade of activated Stat3 in highly metastatic C4 cells significantly suppressed the

61 e expression of a dominant-negative Stat3 in highly metastatic C4 tumor cells inhibited the MMP-2 pro

62 K-1735 melanoma system, we demonstrated that highly metastatic C4, M2, and X21 tumor cells express el

63 l that Trp consumption and Kyn production by highly metastatic cancer cells (HT29) were significantly

64 and invasion and that MTA1 overexpression in highly metastatic cancer cells drives cell migration and

65 For highly metastatic cancer cells, the pH measured at the s

66 Nasopharyngeal carcinoma (NPC) is a highly metastatic cancer that is consistently associated

67 Uveal melanoma (UM) is a highly metastatic cancer that, in contrast to cutaneous

68 cells from hepatocellular carcinoma (HCC), a highly metastatic cancer, undergo epithelial to amoeboid

69 but significantly reduced the likelihood of highly metastatic cancer.

70 si-mesenchymal state that is associated with highly metastatic capabilities and poor survival of pati

71 In conclusion, the highly metastatic capability of a unique TS subpopulatio

72 y a poorly metastatic cell line to that by a highly metastatic cell line 24 h after injection in the

73 -2 mRNA stabilization in MDA-MB-231 cells, a highly metastatic cell line derived from a human mammary

74 ential reversal of oncogenic properties of a highly metastatic cell line with the introduction of non

75 ially expressed (greater than 2-fold) in all highly metastatic cell lines relative to their reference

76 The undifferentiated, highly metastatic cell lines with high metastatic potent

77 We found that in vivo selected highly metastatic cell populations showed little genetic

78 Highly metastatic cells (MDA-MB-435) expressing high lev

79 Within minutes of adhesion, the highly metastatic cells acquire the ability of enhanced

80 subset of drug-resisting, self-renewing, and highly metastatic cells called tumor initiating cells or

81 ere we show that loss of c-KIT expression in highly metastatic cells correlates with loss of expressi

82 at up-regulation of MCAM/MUC18 expression in highly metastatic cells correlates with loss of expressi

83 ration of miR-10b antagomirs to mice bearing highly metastatic cells does not reduce primary mammary

84 Highly metastatic cells evade this tumor-suppressive pat

85 ompared with poorly metastatic cancer cells, highly metastatic cells expressed increased levels of th

86 Highly metastatic cells growing in culture constitutivel

87 Highly metastatic cells growing in the prostate expresse

88 usly shown that enforced c-KIT expression in highly metastatic cells inhibited tumor growth and metas

89 ational regulator, and its downregulation in highly metastatic cells leads to the lengthening of 3' u

90 Silencing of IL-13Ralpha2 in highly metastatic cells led to a decrease in adhesion ca

91 Does it arise from rare, variant, highly metastatic cells or does a primary tumor progress

92 Introduction of Psap in highly metastatic cells significantly reduced the occurr

93 Loss of CC3 in highly metastatic cells such as SCLC might render them r

94 Highly metastatic cells survived to produce numerous lun

95 When the highly metastatic cells were compared with their low met

96 The pH at the surfaces of highly metastatic cells within tumors was found to be ab

97 kinase expression was first demonstrated in highly metastatic cells, whilst re-expression of the pro

98 s phosphoinositide 3-kinase, AKT, and SRC in highly metastatic cells.

99 n upon miR-200 overexpression toward that of highly metastatic cells.

100 elta levels were relatively increased in the highly metastatic cells.

101 transcripts displaying reduced stability in highly metastatic cells.

102 gainst poorly metastatic cells compared with highly metastatic cells.

103 ignificantly impairs the bone progression of highly metastatic cells.

104 etastatic variants, suggest that not only do highly-metastatic cells display constitutively elevated

105 g ligand activation of the EGFR, but only in highly-metastatic cells.

106 ecause they preferentially activate c-Src in highly-metastatic cells.

107 ces neoplastic transformation and promotes a highly metastatic cellular phenotype.

108 ch, in turn, are likely to contribute to the highly metastatic character of NPC.

109 cancers in humans due to late detection and highly metastatic characteristics.

110 Overexpression of NOS II in a highly metastatic clone by transfection with NOS II gene

111 A highly metastatic clone of K1735 cells, SW1-C, and its s

112 Furthermore, both poorly and highly metastatic clones contained an identical p53 muta

113 Highly metastatic clones exhibited higher levels of NOS

114 rays to analyze the secretomes of poorly and highly metastatic colorectal cancer cells.

115 Suppression of Akt2 expression in highly metastatic colorectal carcinoma cells inhibits th

116 e type II TGF-beta receptor (PyMT(mgko)) are highly metastatic compared with control PyMT-induced car

117 noma (NPC), an EBV-associated malignancy, is highly metastatic compared with other head and neck tumo

118 d nitrogen radicals that kill weakly but not highly metastatic CRC cells.

119 In the highly metastatic CT26 murine colon cancer cell line, wh

120 Nearly 10-fold more highly metastatic CX-1 cells survive within the livers o

121 lone A and MIP-101 cells at 24 h but <15% of highly metastatic CX-1 cells.

122 ne A and MIP-101 CRC cells die, whereas many highly metastatic CX-1 CRC cells survive.

123 ndent cells but was significantly reduced in highly metastatic derivative clones.

124 an prostate carcinoma cell line PC-3 and its highly metastatic derivative PC-3M.

125 Ovarian cancer is an highly metastatic disease characterized by ascites forma

126 s evaluated, all were demonstrated to effect highly metastatic disease involving multiple organs, alt

127 pe of a murine model of pancreatic cancer, a highly metastatic disease that frequently displays p53 m

128 Lung squamous carcinoma (LUSC) is a highly metastatic disease with a poor prognosis.

129 Ovarian cancer (OC) is a highly metastatic disease, but no effective strategies t

130 Ovarian cancer is a highly metastatic disease.

131 Highly metastatic Dunning AT3.1 rat prostate cancer cell

132 eomycin resistance gene, was introduced into highly metastatic Dunning AT6.1 prostate cancer cells by

133 xpression of a dominant-negative CDK5 in the highly metastatic Dunning AT6.3 prostate cancer cell lin

134 results in metastasis suppression in certain highly metastatic Dunning R-3327 rat prostatic cancer su

135 er to introduce human chromosome 16 into the highly metastatic Dunning rat prostatic cancer cell line

136 inally, EGFR-MET signaling was enhanced in a highly metastatic EGFR-mutant cell subpopulation, compar

137 helial (EpCAM(hi)) and quasi-mesenchymal and highly metastatic (EpCAM(lo)) cells in conventional huma

138 minyltransferase (LARGE) gene in a cohort of highly metastatic epithelial cell lines derived from bre

139 This resulted in generation of highly metastatic epithelial-to-mesenchymal transition-l

140 53(R172H) mutation were undifferentiated and highly metastatic, exhibited minimal TP53 transactivatio

141 Here we report that these tumors become highly metastatic following hemizygous deletion of the N

142 e and to an in vivo-derived subline that was highly metastatic for growth in the lungs.

143 Osteosarcoma is a highly metastatic form of bone cancer in adolescents and

144 crine PrCa (NEPrCa), a highly aggressive and highly metastatic form of PrCa, for which there is no ef

145 c potential and its experimentally selected, highly metastatic form.

146 criptional regulation of the MMP-9 gene in a highly metastatic H-ras and v-myc transformed rat embryo

147 Highly metastatic H7 murine pancreatic adenocarcinoma ce

148 Another cell line, UMRC3, is highly metastatic, having lost TBR3 and TBR2 expression.

149 xpression of TIMP2 open reading frame in the highly metastatic HCC cell line, MHCC-97L, significantly

150 votal role in regulating RUNX2 expression in highly metastatic HNSCC cells, where it was downregulate

151 ricle injection into nude mice to identify a highly metastatic human breast cancer cell line (MDA-MET

152 oRNA-146b (miR-146a/b) when expressed in the highly metastatic human breast cancer cell line MDA-MB-2

153 functionally relevant betaAR subtype in the highly metastatic human breast cancer cell line MDA-MB-2

154 timigratory and antiinvasive effects against highly metastatic human breast cancer MDA-MB-231 cells v

155 in 3F (SEMA3F) was markedly downregulated in highly metastatic human cell lines in vitro and in vivo,

156 MUC2 levels were manipulated in highly metastatic human colon cancer cells using eukaryo

157 nst proteins preferentially expressed by the highly metastatic human epidermoid carcinoma cell line,

158 eLa (human cervical cancer), HCI-H460-LNM35 (highly metastatic human lung cancer) and B16 (murine mel

159 tisense cathepsin B-expressing clones of the highly metastatic human melanoma A375M and prostate carc

160 ected the c-KIT gene into the c-KIT negative highly metastatic human melanoma cell line A375SM and su

161 al human melanocyte cell line and weakly and highly metastatic human melanoma cell lines, we presentl

162 Medium conditioned by a highly metastatic human pancreatic cancer cell line BxPC

163 i-amino-C1-C3-alkane-sulfonic acid), against highly metastatic human pancreatic carcinoma cells injec

164 Highly metastatic human pancreatic carcinoma L3.6pl cell

165 The highly tumorigenic and highly metastatic human transitional cell carcinoma (TCC

166 nvasive, murine colon cancer cells that were highly metastatic in an immunocompetent mouse model to i

167 The primary neoplasm generated is a highly metastatic islet cell carcinoma of the pancreas.

168 nscript stability measurements in poorly and highly metastatic isogenic human breast cancer lines.

169 Evidence is now provided, using weakly and highly metastatic isogenic melanoma variants, that mda-9

170 CD44 on the highly metastatic KM12L4 clone is more heavily substitut

171 In addition, highly metastatic L3.6pl cells growing in the pancreas e

172 th transformation of SB2 melanoma cells to a highly metastatic line.

173 cally defective liver stem cells (LSCs) into highly metastatic liver cancer cells in premalignant liv

174 xA also reduced motility and invasiveness of highly metastatic LOX melanoma cells.

175 Mucin purified from highly metastatic LS-Lim6 human colon cancer cells bound

176 ated with the Epstein-Barr virus (EBV), is a highly metastatic malignant tumor.

177 e expression of CXCR4 in murine 4T1 cells, a highly metastatic mammary cancer cell line that is a mod

178 Suppression of Twist expression in highly metastatic mammary carcinoma cells specifically i

179 early completely inhibits lung metastasis of highly metastatic mammary carcinoma cells.

180 We define ECM signatures of poorly and highly metastatic mammary carcinomas and these signature

181 Using a highly metastatic mammary tumor cell line that expresses

182 In the mouse, the development of highly metastatic mammary tumors is associated with an a

183 icantly, the HMG-Y protein isolated from the highly metastatic MCF-7/PKC-alpha cells possesses a uniq

184 tion of methylation reduces migration of the highly metastatic MDA-MB-231 breast cancer cell line.

185 gnificantly increased the penetration of the highly metastatic MDA-MB-231 breast cancer cells across

186 20S proteasome and 26S proteasome in intact highly metastatic MDA-MB-231 breast cancer cells, result

187 urthermore, forced expression of KLF4 in the highly metastatic MDA-MB-231 breast tumor cell line was

188 n-invasive MCF7 (56%) cells, but not for the highly metastatic MDA-MB-231 cell.

189 oduced a normal human chromosome 11 into the highly metastatic MDA-MB-435 breast carcinoma cell line

190 ry matrix supported motility and invasion in highly metastatic MDA-MB-435 cells, but not in cells wit

191 s found to suppress motility and invasion in highly metastatic MDA-MB-435 cells, whereas involution m

192 nes, nor was a difference observed between a highly metastatic melanoma cell line (A375SM) or its par

193 progression, we conducted a microarray on a highly metastatic melanoma cell line in which NFAT1 expr

194 ated receptor-1 (PAR-1)] is overexpressed in highly metastatic melanoma cell lines and in patients wi

195 wth (P < 0.01) and metastasis (P < 0.001) of highly metastatic melanoma cell lines in vivo.

196 showed that inducible expression of CD82 in highly metastatic melanoma cells significantly increased

197 Forced expression of TRAF2DeltaN in HHMSX highly metastatic melanoma cells that lack Fas expressio

198 on of the invasive and migratory behavior in highly metastatic melanoma cells, similar to the overexp

199 we use an in vivo selection scheme to select highly metastatic melanoma cells.

200 anocytes, we observed variably pigmented and highly metastatic melanoma with 100% penetrance.

201 onal CDK5 knockout mice and a mouse model of highly metastatic melanoma, we found that CDK5 is dispen

202 Exosomes from highly metastatic melanomas increased the metastatic beh

203 using retroviral vectors in EpRas cells and highly metastatic mesenchymal mouse colon carcinoma cell

204 a critical role in keeping cancer cells in a highly metastatic mesenchymal state.

205 Highly metastatic MeWo human melanoma cells were transfe

206 It is highly metastatic, migrating through lymph nodes to dist

207 To explore this possibility, the highly metastatic MMTV-PyMT mice were crossed with 25 AK

208 Furthermore, highly metastatic MNNG-HOS cells have increased levels o

209 Using a highly metastatic model of mammary cancer, we identified

210 In vitro analysis of a highly metastatic mouse mammary tumor cell line ectopica

211 Here we observed that highly metastatic mouse mammary tumours acquired more in

212 Cells derived from a highly metastatic mouse model of SCCHN were used to conf

213 The two cell lines used were the highly metastatic MTLn3 cells and nonmetastatic MTC cell

214 erinuclear and at the leading edge), whereas highly metastatic MTLn3 cells have only a perinuclear di

215 beta 2m protein and RNA are not expressed in highly metastatic, multidrug-resistant MCF-7/Adr cells w

216 fluorescently labeled exosomes derived from highly metastatic murine breast cancer cells distributed

217 ting angiogenesis and lymphangiogenesis in a highly metastatic murine model of Burkitt's lymphoma (E

218 a human alveolar basal epithelial (A549) and highly metastatic murine osteosarcoma (K7M2) cells lines

219 PANC02-H7 highly metastatic murine pancreatic adenocarcinoma cells

220 Ab induces a substantial survival benefit in highly metastatic murine TNBC models poorly responsive t

221 vivo gene therapy modalities to counter the highly metastatic nature of human melanoma.

222 any potential link between the virus and the highly metastatic nature of MCC.

223 k between MCPyV T antigen expression and the highly metastatic nature of MCC.

224 ancreatic cancer to other organs, due to the highly metastatic nature of the disease.

225 nduce apoptosis of human melanomas including highly metastatic ones despite their low surface Fas lev

226 in the majority of osteosarcoma cases and in highly metastatic osteosarcoma cell lines.

227 metastasis, poorly metastatic Panc02-H0 and highly metastatic Panc02-H7 cells were injected into the

228 B with an oncogenic Kras allele, we observed highly metastatic pancreatic adenocarcinomas.

229 ciency cooperates with Kras(G12D) to promote highly metastatic pancreatic cancer.

230 We then demonstrated in a highly metastatic pancreatic mouse tumor model (Panc-02)

231 lencing MUC4 expression in an aggressive and highly metastatic pancreatic tumor cell line CD18/HPAF t

232 t case, the invasive ascents of the Tepui by highly metastatic PC-3 and noninvasive LNCaP prostate ca

233 nt LNCaP, hormone-independent DU145, PC-3 to highly metastatic PC-3M cancer cell lines.

234 Highly metastatic PC-3M human prostate cancer cells were

235 Highly metastatic PC-3M human prostate cancer cells were

236 Highly metastatic PC3 and PC3M-LN4 cells were found to a

237 poptosis in poorly metastatic PC3 M-Pro4 and highly metastatic PC3 M-LN4 subclones demonstrated that

238 In the highly metastatic PC3-MM2 cells, expression of a non-pho

239 sitively regulates E-cadherin and suppresses highly metastatic PCA cell invasion by modulating Rho pa

240 a1 in regulation of INPPB, we engineered the highly metastatic PCa cell line, PC3, to express ERbeta1

241 that miR-25 can act as a tumor suppressor in highly metastatic PCSCs by direct functional interaction

242 In a mouse model of osteosarcoma, a highly metastatic pediatric cancer, we found ezrin to be

243 ggest a possible molecular mechanism for the highly metastatic phenotype associated with MCC.

244 beta4 integrin was sufficient to revert this highly metastatic phenotype in the MNNG-HOS model withou

245 wth factor (EGF) receptor (EGFR) indicates a highly metastatic phenotype of breast cancer.

246 vels of GLI1 are likely to contribute to the highly metastatic phenotype of PDAC.

247 ogressively lost as the cells take on a more highly metastatic phenotype.

248 onsive, estrogen receptor (ER) negative, and highly metastatic phenotype.

249 s of proteases and angiogenic factors, and a highly metastatic phenotype.

250 opically to regulate an undifferentiated and highly metastatic phenotype.

251 dermal growth factor receptor)-positive, and highly metastatic phenotype.

252 oma (PDAC), a cancer type characterized by a highly metastatic phenotype.

253 p27 knockdown in highly metastatic PI3K-activated cells reduces STAT3 bin

254 Cell velocity in the highly metastatic population shows a relative insensitiv

255 lusters are both increasingly appreciated as highly metastatic precursors and virtually unexplored.

256 Rapid, specific adhesion of highly metastatic prostate adenocarcinoma cells (PC3M-LN

257 n at both the mRNA and protein levels in the highly metastatic prostate cancer cell line PC3.

258 st completely inhibited lung colonization of highly metastatic prostate cancer cells without affectin

259 tional regulator, is abnormally expressed in highly metastatic prostate cancer cells.

260 In contrast, highly metastatic prostate carcinoma cells were resistan

261 pluripotency in embryonic stem cells and in highly metastatic prostate tumors.

262 ersely, recombinant expression of Cav-1 in a highly metastatic PyMT mammary carcinoma-derived cell li

263 were transfected and stably expressed in the highly metastatic rat Dunning MAT-LyLu prostate cancer c

264 d with lycopene against proliferation of the highly metastatic rat prostate adenocarcinoma MAT-LyLu c

265 SPARC selectively supports the migration of highly metastatic relative to less metastatic prostate c

266 We used J774 tumors (a highly metastatic reticulum cell sarcoma line) and PDT w

267 r to introduce normal human chromosomes into highly metastatic rodent prostatic cancer cells to map t

268 mplete inhibition on invasion (P < 0.001) of highly metastatic SiHa cells via reduced transcriptional

269 6.1, without metastasis suppression in other highly metastatic sublines, such as AT3.1.

270 in-7 expression in poorly differentiated and highly metastatic SW620 colon cancer cells induced epith

271 ong epithelial gene program were enriched in highly metastatic TICs, while a second subpopulation wit

272 for these cells revealed that CSCs that are highly metastatic to bone and brain expressed significan

273 -MB cells, a breast cancer cell line that is highly metastatic to bone.

274 NME1(LOW) cells were also highly metastatic to lung and liver when xenografted sub

275 A murine melanoma cell line highly metastatic to lymph nodes (B16F10) was implanted

276 , FAK expression is increased in a number of highly metastatic tumor cell lines.

277 ate that secretion of inhibitory TFPI-2 by a highly metastatic tumor cell markedly inhibits its growt

278 within extracellular vesicles secreted from highly metastatic tumor cells can be internalized by wea

279 In vivo tumor modeling studies with a highly metastatic tumor line, PC-3ML cells, revealed tha

280 titumor efficacy and overall survival in two highly metastatic tumor models.

281 rate that several proteins characteristic of highly metastatic tumors (LTBP3, SNED1, EGLN1, and S100A

282 ant organs, whereas inhibition of miR-105 in highly metastatic tumors alleviates these effects.

283 n, which can be defeated in the evolution of highly metastatic tumors by combined loss of both p66(Sh

284 sing a mouse model of metastasis reveal that highly metastatic tumors express proteolyzed cyclin E an

285 Instead, these mice develop highly metastatic tumors of neuroendocrine, not epitheli

286 Consistently, highly metastatic tumors upregulated multiple pyrimidine

287 the control clones produced rapidly growing, highly metastatic tumors within 2 wk of inoculation on c

288 oss in the mouse lung to promote aggressive, highly metastatic tumors, that are initially sensitive t

289 we found that 4.1B expression is reduced in highly metastatic tumors.

290 or discrimination between non-metastatic and highly metastatic tumors.

291 cell lines, POS (low metastatic) and HMPOS (highly metastatic), under normoxia and hypoxia.

292 e human-human somatic cell fusions between a highly metastatic, undifferentiated, ER-negative line of

293 rom the compound mutant prostates, which was highly metastatic upon orthotopic transplantation.

294 o search for metastasis-related mutations in highly metastatic uveal melanomas of the eye.

295 an prostate cancer cell line LNCaP, with its highly metastatic variant LNCaP-LN3, by two-dimensional

296 man breast carcinoma MDA-MB-435-F-L cells, a highly metastatic variant of human breast cancer MDA-MB-

297 c GI101A human breast cancer cell line and a highly metastatic variant, GILM2.

298 y be essential for this process, we isolated highly metastatic variants from a poorly metastatic huma

299 ic vs. immunosuppressed newborn rat-selected highly metastatic variants.

300 However, HCT116 was highly metastatic with 68% metastasis observed in liver