ライフサイエンスコーパス: highly specific

1 These reactions with rLb6H were highly specific (98.5%) when compared against those for

2 By using a highly specific Ab against a cleavage neoepitope in C4d,

3 estion using Siglech(dtr) mice, which enable highly specific ablation of microglia.

4 that regulates the long-lived production of highly specific Abs by B cells during the germinal cente

5 nases can sense distinct threats and perform highly specific adaptive responses.

6 mophilic variant of protein G (HTB1), into a highly specific aggregation inhibitor (designated HTB1M)

7 s an unexplored subtype that responds to its highly specific agonist absinthin.

8 mechanisms remain unclear, the existence of highly specific alloreactive TCRs has led to their use a

9 Here, we report the identification of a highly specific allosteric inhibitor of Akt through a FR

10 improved explosive detecting system that is highly specific and capable of quickly determining the p

11 panel to be utilized in the development of a highly specific and cost-effective ZIKV rapid quantifica

12 gens that provoke an immune response that is highly specific and dependent on the host major histocom

13 monovalent cations, that ion condensation is highly specific and depends on the nucleotide position.

14 s of 137 and 634 proteins, respectively, are highly specific and highlight 94 potentially novel mitoc

15 Both assays are highly specific and identify down to 0.1% of their targe

16 that one of the simplest animals has evolved highly specific and intimate associations with symbiotic

17 ggesting that TRIC-B-TRIC-B interactions are highly specific and may be important for meeting counter

18 ultiple sites on PSD-95, thus resulting in a highly specific and multivalent stargazin/PSD-95 complex

19 This test has shown to be highly specific and reproducible and able to detect MSV

20 Here we developed a highly specific and robust bimolecular luminescence comp

21 nt cell culture systems due to the lack of a highly specific and selective HBx antibody.

22 or carbon sites by alkysulfamide group(s) as highly specific and selective inhibitors of CAIX.

23 ailability of fluorescent fusion proteins or highly specific and sensitive antibodies.

24 INTERPRETATION: This new highly specific and sensitive assay showed asymptomatic

25 Diagnostic systems that can deliver highly specific and sensitive detection of hepatitis A v

26 In summary, using highly specific and sensitive DNA-SWCNT nanosensors, whi

27 that pathogenic variants in EZH2 generate a highly specific and sensitive DNAm signature reflecting

28 ers, which were used to generate two unique, highly specific and sensitive DNAm signatures.

29 These devices are not only highly specific and sensitive for the parameters being a

30 xt of natural infection due to the lack of a highly specific and sensitive HBx antibody.

31 minimally invasive sample collection with a highly specific and sensitive mass spectrometry (MS) tec

32 say based on latent redox probe approach for highly specific and sensitive quantification in living c

33 These could be accomplished by using highly specific and sensitive substrates, as well as dir

34 Here, we describe highly specific and sensitive top-down and middle-down M

35 The biosensor proved to be highly specific and sensitive, achieving a limit of dete

36 These new assays were highly specific and sensitive.

37 l-to-cell movement of plant rhabdoviruses is highly specific and suggest that cognate MP-nucleocapsid

38 We here leverage a highly specific and targeted rapid PCR methodology to qu

39 e susceptible and resistant interactions are highly specific and that novel and stably inherited meth

40 presents a great potential for understanding highly specific and tightly regulated interactions in bi

41 e, use of up to 4 to 6 primers (rendering it highly specific), and capability of amplifying low copie

42 The proposed immunosensor is 'easy to use', highly specific, and can be used as a quantitative tool

43 label-free methodology is sufficiently fast, highly specific, and sensitive to be used in direct in-f

44 g subfamily membership, and that it produces highly specific annotations of GO terms based on annotat

45 We aimed to assemble a highly specific anti-Zika antibody panel to be utilized

46 nd medicine due to the broad availability of highly specific antibodies and well-established bioconju

47 erties, their low abundance, and the lack of highly specific antibodies, GPCRs are still challenging

48 While the Fab domains mediate highly specific antigenic recognition to block virus ent

49 Custirsen (OGX011) is a second generation highly specific antisense oligonucleotide that inhibits

50 sary tumor-targeting immune infiltrate and a highly specific antitumor immune response.

51 luidic platform equipped with 1) immobilized highly specific aptamer probes and 2) field-effect trans

52 ir regulatory function is the formation of a highly specific aptamer-ligand complex.

53 Two highly specific aptamers, crn-1 and crn-2, were develope

54 [(18)F]BF4(-)-PET was also highly specific as in all detected tissues cancer cell p

55 This inhibition was highly specific as multiple viruses, including influenza

56 This blockade of PKR function is highly specific, as LCMV is unable to similarly inhibit

57 ors have evolved remarkable sensitivities to highly specific aspects of membrane structure and dynami

58 Focusing on highly specific aspects of the immune response is likely

59 However, the mechanisms that underlie the highly specific assembly of ascarosides are not understo

60 ib, and abemaciclib represent a new class of highly specific ATP-competitive CDK4/6 inhibitors that i

61 erax volcanii possess an extremely high, and highly specific, basal caspase activity in exponentially

62 The technique is highly specific because we observed no off-target protei

63 Candida albicans as a model, we identified a highly specific bifunctional molecule able to mediate th

64 icial symbiont Vibrio fischeri, which form a highly specific binary mutualism.

65 We applied pY-TRAP to create highly specific binders to folded Ub-pY59, a rarely stud

66 ng site is a prerequisite for the subsequent highly specific binding of a second RR dimer to the low-

67 are tailored with a monoclonal antibody for highly specific biological recognition (BSW biochip).

68 sphorylated at threonine 181 (p-tau181) is a highly specific biomarker for Alzheimer's disease pathol

69 A highly specific biotinylated DNA/LNA molecular beacon (M

70 r data may contribute towards designing new, highly-specific, Bm86 antigen vaccine candidates against

71 We further found that highly specific bone fracture targeting of multiple pept

72 Treatment of Nlgn3-knockout mice with a new, highly specific, brain-penetrant inhibitor of MAP kinase

73 The current WHO ILI case definition was highly specific but had low sensitivity.

74 Conclusion US is highly specific but nonsensitive for perforated pediatri

75 oated with a multilayer assembly that allows highly specific capture of EpCAM (epithelial cell adhesi

76 ines that our non-invasive approach achieves highly specific capture rates of bladder cancer cells ba

77 rm for the modular design of a collection of highly specific CB(2)R fluorescent probes, used successf

78 The highly specific CDK7 kinase inhibitors, BS-181 and THZ1,

79 Highly specific cell shape recognition can also be achie

80 quencing has enabled the characterization of highly specific cell types in many tissues, as well as b

81 d show that two of them mediate distinct and highly-specific changes in leg muscle activity during ba

82 here the ligation of these two gives rise to highly specific chimeric ring structures.

83 nostic kit, which offers the potential for a highly specific clinically-relevant detection system.

84 a infects the honey bee gut, which harbors a highly specific, coevolved microbiota heavily involved i

85 dendrites are only sparsely recruited under highly specific conditions in vivo, our results provide

86 s (RTKs) results in their activation through highly specific conformational changes in the extracellu

87 DVR that form the core of a dense network of highly specific connections between this region and othe

88 This provides a highly specific contrast mechanism that can be used to r

89 condary-cell secretions might therefore make highly specific contributions to the seminal proteome an

90 s tagged using a system that rapidly forms a highly specific covalent bond to its cognate catcher lin

91 dings suggest that recent loss of smell is a highly specific COVID-19 symptom and should be considere

92 Highly specific CPX imprinted nanoparticles were synthes

93 Overall, we have identified highly specific CRISPR targets that significantly reduce

94 We found that AMD3100, a highly specific CXCR4 antagonist, directly down-regulate

95 Laser ablation of NI caused highly specific deficits in tectally mediated loom-avoid

96 as shown a tremendous potential to provide a highly specific detection of target analyte/molecule wit

97 ction agents, respectively, giving rise to a highly specific detection of Zika NS1 with a detection l

98 ass measured for the intact lipid as well as highly specific diagnostic product ions that reveal both

99 Immunofluorescence is a highly specific diagnostic test for PCD, and it improves

100 We are presenting a highly specific diagnostic tool for the detection of SAR

101 We found that the T2Candida panel is a highly specific diagnostic tool; however, the sensitivit

102 tion success with prevalences close to zero, highly specific diagnostics are necessary.

103 Australian koala is an iconic marsupial with highly specific dietary requirements distributed across

104 ormational changes and learn that there is a highly specific direction for applied forces to drive th

105 We used a highly specific discovery proteomic approach (Protein Ex

106 egrees of binding specificity, we found that highly specific DNA-binding proteins show balanced hydro

107 strand and coil secondary structure types in highly specific DNA-binding proteins while multi-specifi

108 A highly specific DNA-functionalized hydrogel sensing laye

109 , we used neuromelanin-sensitive MRI and the highly specific dopamine transporter PET radioligand, 11

110 quadruplex targeting strategy by conjugating highly specific duplex-binding molecules with potent qua

111 The functioning of proteins requires highly specific dynamics, which depend critically on the

112 In summary, our findings indicate highly specific effects of NTZ on the usher folding path

113 quired for rRNA methylation has profound and highly specific effects on organismal development and ph

114 hecal application of endomorphin 2 [EM2; the highly specific endogenous mu-opioid receptor (MOR) liga

115 as then further enhanced with the use of the highly specific endonuclease dsDNase for an enzymatic am

116 c separation of glycopeptides resulting from highly specific enzymatic digestions.

117 The glyoxalase system is a highly specific enzyme system existing in all mammalian

118 of these cells, extracellular cues determine highly specific epigenetic landscapes and transcriptiona

119 that genomic signatures of adaptation can be highly specific, even with respect to subtle environment

120 excitatory neurons, despite the presence of highly specific excitatory connectivity, which was deeme

121 rimental conditions while ideally also being highly specific, extremely sensitive, and spatially conf

122 overcomes these disadvantages, as these are highly specific, fast, easy, cost effective, and highly

123 is a promising candidate for development of highly specific fibrinolysis inhibitors with reduced sid

124 address this, we present an approach that is highly specific for a target miR sequence and has the ab

125 X40 (CD134) is a cell surface marker that is highly specific for activated T cells, is upregulated du

126 Sensitization to Pru du 6 was highly specific for almond allergy, while frequencies of

127 We found p-tau-217 and p-tau-181 were highly specific for amyloid plaque pathology in the disc

128 ION: GFAPalpha-IgG, when detected in CSF, is highly specific for an immunotherapy-responsive autoimmu

129 This connectivity pattern was highly specific for delusional misidentifications compar

130 ients, and the presence of aberrant CD56 was highly specific for detecting a mutation.

131 o observed that this binding interaction was highly specific for Dmc1 and found no evidence for an as

132 esion molecules, and cytokine transcripts is highly specific for each model, not shared with advanced

133 The assay is highly specific for each target gene and is not affected

134 daA, representing peptidoglycan deacetylases highly specific for GlcNAc or MurNAc residues, respectiv

135 mporter (GlcP(Se)) is a membrane transporter highly specific for glucose and a homolog of the human g

136 and the presence of endometrial echoes were highly specific for identifying the onset of puberty, pa

137 This effect of PD-1H is highly specific for iTreg because both naturally generat

138 At 7 days, IgM and macrophages were highly specific for NPIs (alpha1,3-galactosyltransferase

139 easingly clear that proteins long-considered highly specific for one or the other cytoskeletal system

140 ty of 1 genomic copy per 4-mul sample and is highly specific for Rickettsia 364D.

141 All assays tested were found to be highly specific for SARS-CoV-2, with no cross-reactivity

142 This biosensor is highly specific for SDS and has minimal interference fro

143 Each of these prenyltransferases was highly specific for stilbenoid substrates, and we confir

144 c, they bind with nanomolar affinity and are highly specific for the 1A3 isoform.

145 CSF Xpert MTB/RIF and CSF LAM are highly specific for the diagnosis of TBM.

146 h a single-stranded oligonucleotide donor is highly specific for the Gaa(c.1826) locus without genomi

147 , and TBP in complex with DNA, our method is highly specific for the mapping of DNA binding domains.

148 Both the COI and 16S assays were highly specific for the targeted organism and showed sim

149 hysical properties in both nucleic acids, is highly specific for thymine/uracil, and maintains and sl

150 allowed upon immunization the generation of highly specific fully human mAbs for therapeutic applica

151 ign of fluorescent activatable chemokines as highly specific functional probes for imaging subpopulat

152 lls to be targeted and killed by F49A-FTP, a highly specific fusion toxin protein that binds this vir

153 RNA interference (RNAi) is a highly specific gene-silencing mechanism that can cause

154 The CRISPR/Cas system is a highly specific genome editing tool capable of distingui

155 Deep-sequencing experiments reveal highly specific, genome-wide DNA insertion across dozens

156 ly assumed fluctuations either occur between highly specific genotypes (matching allele: MA) or from

157 three-dimensional microconstructs, evincing highly specific geometry that includes control over posi

158 These results reveal a highly specific GlcNAc-binding pocket in conglutinin and

159 ineer an improved tRNA scaffold that enables highly specific guide RNA production from a Pol-II promo

160 There is an urgent need for highly specific IGF-1 and IGF-2 antibodies, yet only a s

161 a protocol for a large-scale production and highly specific immobilization of Im7 to a solid support

162 nabled biosensor to detect Zika virus with a highly specific immobilized monoclonal antibody.

163 called allelic exclusion, is fundamental for highly specific immune responses to pathogens.

164 t of two recombinant plant rhabdoviruses was highly specific in requiring their cognate MPs.

165 These mutant-p53-specific siRNAs (MupSi) are highly specific in silencing the expression of the inten

166 al nerve stiffness measurements appear to be highly specific in the diagnosis of established DPN.

167 e to multiple steviol substrates yet remains highly specific in the glycosidic linkage it creates.

168 The assay was also found to be highly specific in the presence of common biopharmaceuti

169 method to demonstrate that tRNA cleavage was highly specific in vivo.

170 9 editing, we provide in vivo evidence for a highly specific inhibition that leaves basal TRPV1 funct

171 f Rapgef3 expression in cells treated with a highly specific inhibitor of LRRK2 protein kinase activi

172 f HIF-2alpha using a clinically relevant and highly specific inhibitor successfully treated iron over

173 a yeast surface display technique to obtain highly specific inhibitors of MMP-14 by modifying the na

174 indings by the ability of calcium to block a highly specific interaction between PLC delta1-PH and PI

175 t remodeling arising from Kcne3 deletion was highly specific, involving just 3 of 69 alpha subunit ge

176 A simple magnet allows highly specific isolation of the labeled cells, which th

177 We demonstrate single-molecule, highly specific, label- and background free-electronic d

178 Moreover this highly specific LAMP detection technique can reduce the

179 at these two EGF-CFC homologs have distinct, highly specific ligand binding activities.

180 eptoid combinatorial cell screen to identify highly specific ligands that bind a CSC subpopulation of

181 LIMK1 expression blocks HIV-1 infection, no highly specific LIMK inhibitor is available.

182 more complete definition, the findings of a highly specific liquid biopsy strongly support moving fo

183 pinpoint the nanoscale dynamics changes in a highly specific manner.

184 ng a portion of its structure (epitope) in a highly specific manner.

185 ly detect antibiotic resistant bacteria in a highly specific manner.

186 Coronary artery calcium (CAC) is a highly specific marker for coronary atherosclerosis.

187 Our data suggest M30 as highly specific marker of liver apoptosis both in ALD an

188 Robust and highly specific methods for the detection of the protein

189 onization of body epithelial surfaces with a highly specific microbial community is a fundamental fea

190 The developed highly specific microcantilever sensor has a response ti

191 ied in vivo, allowing for the fabrication of highly specific microsensors to study NO physio-patholog

192 lly performed using expensive instruments or highly-specific miniaturized sensors.

193 as provided an unprecedented opportunity for highly specific modulation of signaling by individual mA

194 ioluminescent detection is a fast, low-cost, highly specific molecular diagnostic technique that is t

195 mponents of human upper limb nerves based on highly specific molecular features from spinal cord leve

196 sure digested peptide mixtures, TDP provides highly specific molecular information that avoids the bi

197 A highly specific molecular interaction of diffusible liga

198 for new radiochemical methods to synthesize highly specific molecules bearing positron-emitting radi

199 Strikingly, we identify a series of highly specific monobodies acting either as strong kinas

200 aise selective anti-OTC rabbit antiserum and highly specific monoclonal antibody (mAb).

201 As a new approach, we developed a highly specific mouse anti-mouse C3d mAb that blocks its

202 We propose a highly specific, mutation-dependent role of activated Ca

203 rity of reported synthesis techniques, their highly specific nature, and lack of mechanistic understa

204 Given the low toxicity and highly specific neuron-targeting properties of BoNT/C1 a

205 provides a foundation for the development of highly specific neuroprotective compounds for the treatm

206 We show highly specific neurotransmitter signaling during neurog

207 LPs) representing different genotypes showed highly-specific neutralization activity against GII.4 an

208 strated that 2-hydroxy-NQs (2-OH-NQs) act as highly specific noncovalent inhibitors of the essential

209 ations of odors are preprocessed to generate highly specific, nonoverlapping odor patterns used for l

210 f SULT1A1 and mefenamic acid (MEF)-a potent, highly specific NSAID inhibitor of 1A1.

211 jor finding of our study was the intense and highly specific nuclear expression of Ataxia Telangiecta

212 cialist insect herbivores are constrained by highly specific odor recognition systems to accept suita

213 Clusters of hyperreflective objects are highly specific of AK.

214 of the adult population of Meliandou used a highly specific oral fluid test and detailed interviews

215 Each stress directed a highly specific pattern of change, which reflected the r

216 beta-lactamase members, and YSVVPVYQEFAR, a highly specific peptide common to 11 of 12 OXA-48 family

217 sensor was then engineered with a novel and highly specific peptide nucleic acid (PNA) as the recogn

218 ntixafor PET/CT is suitable for noninvasive, highly specific PET imaging of CXCR4 expression in the a

219 ignaling through in vivo administration of a highly specific pharmacologic inhibitor (1NM-PP1) of Ret

220 Using Phos-tag, a highly specific phosphate binding tag for separating pho

221 However, introducing low densities of a highly specific piscivorous fish into the community to p

222 Here, we report on a highly-specific, potent, and efficacious activator of br

223 In principle, maintaining a large set of highly specific priors may be inefficient and restrict t

224 nt unneeded antibiotic prescriptions require highly specific probes with sensitive and accurate trans

225 ermal systems and the importance of coupling highly specific process indicators to elucidate the comp

226 s involved in general proteolysis as well as highly specific processing proteases.

227 We used ADAPT as a highly specific profiling tool that distinguishes women

228 be derived from distinct progenitors, their highly specific properties are shaped by the local envir

229 LF is a highly specific protease, exclusively cleaving mitogen-a

230 ease states by releasing exosomes containing highly specific protein and RNA cargos, but how inflamma

231 BI-3802 can induce polymerization coupled to highly specific protein degradation, which in the case o

232 acid side chains, are more prevalent in the highly specific protein-DNA complexes than those in the

233 and angiogenesis, and its transport entails highly specific protein-protein interactions.

234 ediate neuronal targeting in the fly through highly specific protein-protein interactions.

235 distinct role throughout the body, obtaining highly specific receptor agonists is essential.

236 Highly specific recognition cavities can be made into po

237 lly weak docking interactions facilitate the highly specific recognition of ERK2 by Ets-1, and enable

238 Here, we utilize the highly specific recognition of ribose by ribose-binding

239 genuine awake resting-state periods leads to highly specific reductions both in activation and interh

240 A) based sensor has been confirmed using the highly specific reference method based on lactate oxidas

241 pendent metabolome, we found significant and highly specific regulation of 11 intracellular metabolit

242 ctivity by using monobodies that bind to the highly specific regulatory allosteric pocket of the onco

243 gulation, demonstrating that Cas9 controls a highly specific regulon of four genes that must be repre

244 The assay is highly specific, reproducible, and sensitive, allowing d

245 ample analysis are validated assays that are highly specific, reproducible, and with known performanc

246 s are voltage-activated to give enhanced and highly specific responses.

247 of a rapid, sensitive, robust, reliable, and highly specific reverse transcription-RPA technique coup

248 ation, in which a small molecule induces the highly specific, reversible polymerization of a target p

249 diversified carbocation chemistry, including highly specific ring formations, proton and hydride tran

250 displaces contaminating species, leading to highly specific RNA capture of individual RNAs.

251 The highly specific S1 serine protease factor D (FD) plays a

252 Complement factor D (FD), a highly specific S1 serine protease, plays a central role

253 The LAMP-ECL sensor is shown to be highly specific, sensitive (>/=0.1pg/muL) and rapid ( ap

254 A robust and highly specific sensor based on electroactive molecularl

255 ique opportunities relative to "traditional" highly specific sensor elements such as antibodies.

256 generated and validated reporter systems as highly specific sensors of zinc stress.

257 ution for each binding site and delineated a highly specific sequence and structure motif for Vts1 bi

258 his method Cas effector proteins are used as highly specific sequence recognition elements that can b

259 wever, diagnosis is straightforward when the highly specific serum aquaporin-4 antibodies are detecte

260 ogical research and medical diagnoses, where highly specific signal enhancement is required.

261 DNA-methylation profiles from plasma reveal highly specific signatures to detect and accurately disc

262 Finally, we demonstrate that a novel, highly specific small molecule inhibitor of JAB1, CSN5i-

263 e packaged as cargo into eHAV vesicles via a highly specific sorting process.

264 es cerevisiae triggers rapid activation of a highly specific stress pathway that coordinately upregul

265 nd their functions are determined in part by highly specific structural features.

266 We identified 23 highly specific structured regions of the genome, and co

267 ple separation is based on the expression of highly specific surface markers CD63 and EpCAM.

268 ing its potential role in initiation of this highly specific symbiosis.

269 tical for HPV16 carcinogenesis, presenting a highly specific target for etiologic and therapeutic res

270 hesis: if a synthetic piece of DNA lacks the highly specific target recognition motifs for a host's R

271 Antibody-drug conjugates (ADCs) harness the highly specific targeting capabilities of an antibody to

272 e that ensembles of dopamine neurons provide highly specific teaching signals, opening new possibilit

273 Although it is highly specific, the sensitivity varies between 20-80% i

274 utoreactive cells offers the potential for a highly specific therapeutic agent for MG.

275 and has implications for the development of highly specific therapeutics.

276 of bacteriophages (phages) is proposed as a highly specific therapy for intestinal pathobiont elimin

277 cal to the function of many proteins are the highly specific three-dimensional structures they adopt.

278 Because the profile of a histone mark is highly specific to a cell type, cell isolation from tiss

279 This relationship is highly specific to a single clade of Haliclona sponges.

280 enome-sequenced tumors identified signatures highly specific to alkylation mutagenesis and indicate t

281 This increase was highly specific to delusion severity as compared to the

282 The enzyme, glutathione reductase, is highly specific to glutathione.

283 with VPS52, and show that the association is highly specific to Mpersicae-host interactions.

284 Importantly, sialylation was highly specific to pathogenic IgG at the site of inflamm

285 -citrullinated peptide antibodies (ACPA) are highly specific to RA and assayed with the commercial CC

286 The method was confirmed to be highly specific to S. typhimurium without interference f

287 cular weight = 20,395 Da) RNA-based aptamer, highly specific to the human IL-23 cytokine, with picomo

288 Increased miR-138 expression is highly specific to this subtype, correlates with poor pr

289 usted by choosing from a continuous range of highly specific to very sensitive parameters.

290 ophore complexes are actively taken up using highly specific TonB-dependent transporters (TBDTs) loca

291 typically 15-25 nt long and considered to be highly specific towards their intended target sequence,

292 2 hours after ACTH administration, involved highly specific, transient (lasting <24 hours) induction

293 he future provide a new, minimally invasive, highly specific treatment method for hyperinsulinemic hy

294 y ultrasound exposure has been shown to be a highly specific treatment modality, making the potential

295 In mesothelioma, we identified a highly specific tumor cell surface antigen that can be t

296 ecific tRNA (tRNASec) drives the recoding of highly specific UGA codons from stop signals to Sec.

297 al types of collectins were endocytosed in a highly specific uPARAP-dependent process, not shared by

298 These motifs are highly specific with implications for both signal proces

299 alysis shows that our biosensing approach is highly specific, with an area under the curve of 1.0.

300 ific gene biomarkers (e.g. AMBP and AHSG) is highly specific, with autopsy-derived organ samples corr