ライフサイエンスコーパス: hinder

1 n of ions, including protons, is efficiently hindered.

2 cular abnormalities after previous DVT often hinder a diagnosis by compression ultrasonography.

3 Natural selection can promote or hinder a population's evolvability-the ability to evolve

4 romine were the chemical components of cocoa hindering Abeta peptide on-pathway aggregation and toxic

5 may limit its access to critical resources, hinder academic promotion, and contribute to physician b

6 ng protective immune response either through hindering access to key epitopes by lymphocytes or throu

7 cing regulates the TEN2-LPHN3 interaction by hindering access to the LPHN-binding surface rather than

8 is a barrier to efficient DNA repair, as it hinders access and processing of certain DNA lesions.

9 ed to six or fewer consecutive base triples, hindering accurate estimation of global and local struct

10 tools exist, the diversity of output formats hinders accurate comparisons between tools and precludes

11 ies related to an aging and damaged soma can hinder achievement of ACM benefit.

12 tured with breast cancer cells in vitro, MCs hindered activation of cMET, a master regulator of the b

13 ns, as philopatry is hypothesized to help or hinder adaptation to climate change depending on the cir

14 How plasticity can contribute or hinder adaptation to different environments hinges on it

15 of a specific cortical architecture does not hinder advanced cognitive skills.

16 art transplant settings that are potentially hindering advancement of this field of investigation.

17 f sepsis at the individual patient level has hindered advances in the field beyond the current therap

18 the applicable material compositions and has hindered advances in this technique.

19 construction of C(sp(3))-rich and sterically hindered alkyl boron reagents in a practical and modular

20 typically high regioselectivity for the less-hindered alpha-position.

21 s been demonstrated at simple and sterically hindered amino acid junctions (Gly, Ala, Trp, Glu).

22 biomarkers meant to capture aging rates has hindered an understanding of the degree to which individ

23 m in which cADORA(1) and pADORA(1) signaling hinder and aggravate DIO, respectively.

24 icantly, this method accommodates sterically hindered and electronically diverse pyrazoles and aldehy

25 and have potent immunosuppressive functions hindering anti-tumor immunity.

26 ed for tremendous amounts of annotation data hinder applications of existing methods in species witho

27 This hinders assay selection and implementation, as well as i

28 found in any other hominin taxon, which has hindered attempts to determine its placement within the

29 brain volumes(5-7), and this complexity has hindered attempts to probe the function of these subnetw

30 h mouse models is that bnAb expression often hinders B cell development.

31 ion of Piezo2 for systemic pain treatment is hindered because of its essential role for mechano-trans

32 , PML pathogenesis research has been greatly hindered because of the lack of an animal model.

33 In contrast, sterically hindered bis-sulfonamides and related nucleophiles react

34 However, progress has been hindered both by the difficulty of identifying individua

35 ng beta-catenin transcriptional interactions hindered both NF-kappaB DNA recruitment and induced prim

36 making cross-study comparisons difficult and hindering broad-scale generalizations.

37 mportant in the cross-coupling of sterically hindered bulky PAHs.

38 ased, but research into peer review has been hindered by a lack of access to peer review reports.

39 ive understanding of cis-clustering has been hindered by a lack of experimental approaches capable of

40 itated by fewer pathogens, but could also be hindered by a lack of mutualists.

41 hannel function of GluDs in neurons has been hindered by a lack of pharmacological tools.

42 t areas of science is drastically slowed and hindered by a lack of standards and networking programme

43 sion of non-alcoholic fatty liver disease is hindered by a lack of suitable non-invasive imaging meth

44 ever, its inclusion in atmospheric models is hindered by a lack of understanding of the first steps o

45 The efficiency of CO(2) flux is hindered by a number of structural and biochemical barri

46 ion of complete mathematical models is often hindered by a pervasive problem: despite the wealth of q

47 Tuberculosis (TB) control is hindered by absence of rapid tests to identify Mycobacte

48 e earliest stages of crown bird evolution is hindered by an exceedingly sparse avian fossil record fr

49 ,3-galactosidase activity of GH43 enzymes is hindered by beta-1,6 branches on beta-1,3-galactans.

50 rial DNA (mtDNA), however, has thus far been hindered by challenges associated with the delivery of g

51 d constructs in preclinical studies is still hindered by complications such as strictures or fistulae

52 ion of the Na metal anode has been primarily hindered by dendritic and "dead" Na formation that leads

53 es remains a desirable goal, but progress is hindered by difficulties in preparing large crystalline

54 pies against mutant BRAF or MEK1/2 have been hindered by existence of innate or development of acquir

55 al component of conservation efforts, but is hindered by inconsistent, unpredictable outcomes.

56 ir use in practical applications is severely hindered by intrinsically narrow band performance.

57 ption of ozonation for water disinfection is hindered by its high ozone demand and the resulting high

58 nderstanding granadaene's toxic activity are hindered by its instability and insolubility in purified

59 vironmental cues eliciting their activity is hindered by laborious in vitro experiments, especially w

60 hicles (BEVs) in fleet applications has been hindered by lack of charging infrastructure and long cha

61 ms to support malaria care pathways has been hindered by lack of data, a tendency towards universal "

62 but understanding how they evolved has been hindered by lack of insight from commonly studied invert

63 nnings of the human threat response has been hindered by lack of realistic in-lab threat paradigms.

64 ermining high-resolution structures has been hindered by latency-a hallmark of EBV infection-and atom

65 espread use of controlled release systems is hindered by limitations, which are discussed in this rev

66 ly investigated; however, its application is hindered by limited cell survival due to the harmful dys

67 However, such engineering is currently hindered by our limited knowledge of plant cis-regulator

68 However, this is hindered by overlapped leucine and valine frequencies.

69 however in practice its performance is often hindered by poor mechanical properties and high roughnes

70 roadly protective antibody responses are not hindered by promotion of terminal plasmacytic differenti

71 mer formation is accelerated by H(2)O(2) and hindered by reducing agents, resulting in faster and slo

72 However, the application of a Zn anode is hindered by severe dendrite formation and side reactions

73 settings with very low prevalence and can be hindered by spatial heterogeneities in risk.

74 thorough understanding of these processes is hindered by that annihilation rates are often convoluted

75 f the mechanism underlying kidney disease is hindered by the almost exclusive use of a few animal mod

76 typic plasticity under natural conditions is hindered by the apparently complex environment and the i

77 development of anti-CoV drugs has long been hindered by the capacity of CoVs to proofread and remove

78 Linking phenotypes to genotypes in F0 was hindered by the complex mosacism and wide indel spectrum

79 adoptive T-cell transfer therapies (ACT) is hindered by the cost and time required for product devel

80 he molecular study of these relationships is hindered by the degradation of ancient DNA.

81 ve analysis of human T-cell specificities is hindered by the diversity of HLA alleles (>20,000) and t

82 Progress in the area is hindered by the fact that error rates of conventional se

83 understanding of their long-term impacts is hindered by the few studies that have simultaneously inv

84 cently, research on the Drosophila brain was hindered by the lack of a complete and uniform nomenclat

85 studies of anaerobic gut bacteria have been hindered by the lack of a fluorescent protein system to

86 for therapeutic development, but progress is hindered by the lack of available information about spec

87 imulus transformations by neural circuits is hindered by the lack of comprehensive yet interpretable

88 practical application to treatment has been hindered by the lack of hospital-scale accelerators.

89 Development of tendon therapeutics has been hindered by the lack of informative adult mammalian mode

90 lizations of mechanical metamaterials remain hindered by the lack of rapid-prototyping ferroelectric

91 validation of this model, however, has been hindered by the lack of specific physiological substrate

92 However, progress is hindered by the lack of suitable analytical methods for

93 However, MS-based methods are still hindered by the large dynamic range between high abundan

94 lore Sec-facilitated protein biosynthesis is hindered by the large system sizes and long (i.e., minut

95 pment of lithium-selenium batteries has been hindered by the low selenium reaction activity with lith

96 e of SCs in nerve regeneration strategies is hindered by the necessity of removing a healthy nerve to

97 However, the practicality of such systems is hindered by the requirement of toxic, flammable organic

98 , but their practical applications have been hindered by the safety and low-efficiency concerns relat

99 ic traits, such as nervous systems, arose is hindered by the scarcity and fragmented nature of genome

100 lag the pace of risk variant identification, hindered by the sheer number of targets and their predom

101 sure-retarded osmosis (PRO) in this work, is hindered by the unsatisfactory membrane transport proper

102 ication of scRNA-seq to prokaryotes has been hindered by their extremely low mRNA abundance(14-16), l

103 gy-density lithium metal batteries have been hindered by their formation and growth of lithium dendri

104 The accuracy of these models, however, is hindered by their inability to capture indirect regulato

105 etentive protonation of the least sterically hindered C-B bond.

106 B[7]), enabling widespread applications, but hindering CB[7] materials from being returned to their g

107 replication, Mdm4 depletion only marginally hindered cell proliferation, likely due to compensation

108 Methodological reasons that have hindered consensus include inconsistent measurements of

109 data has become one of the major bottlenecks hindering crop breeding and functional genomics studies.

110 ecause of their low solubility and the often hindered cyclodehydrogenation reaction of their nonplana

111 ug activation, but genetic heterogeneity has hindered development of a molecular diagnostic test.

112 sion symptoms are not completely understood, hindering development of novel treatments.

113 reporting of deaths of older individuals can hinder direct comparisons of mortality rates and the und

114 downstream PI3K pathway activation and also hindered DNA double-strand break repair, which both led

115 use of these materials, however, is greatly hindered due to challenges in material handling and depl

116 ract knowledge from these large datasets are hindered due to the lack of formalization methods and to

117 n of material-associated diseases, currently hindered due to the lack of in-depth understanding of ca

118 riction, where the chains still interact and hinder each other: the first Zimm relaxation time is as

119 However, acquired epigenetic states can also hinder effective tumor immunity or contribute to autoimm

120 This hinders effector T-cell infiltration, proliferation and

121 t utilization among PWID in some areas could hinder efforts to end the intertwined human immunodefici

122 adaptation to limited iron availability has hindered efforts to identify optimal supplementation str

123 clines in different populations or contexts, hindering efforts to improve bee health.

124 emit light that is poorly tissue penetrant, hindering efforts to visualize targets in deep tissues.

125 ial pharmacokinetics (PK) at infection sites hinders efforts to optimize antimicrobial dosing and sho

126 on increases, the ion adsorption on the PTFE hinders electron transfer and results in the suppression

127 nd the aza-Morita-Baylis-Hillman reaction of hindered electrophiles.

128 allocation versus acquisition of resources, hindering empirical testing.

129 l storage disorders in which immune response hinders ERT.

130 the lack of genomic resources for Dalbergia hinders evolutionary studies and conservation applicatio

131 simultaneously accelerate hole injection and hinder excessive electron injection.

132 ange) and poor fragmentation characteristics hinder facile simultaneous quantification by liquid chro

133 cientific issues and technical problems that hinder further development of these materials for use in

134 ledge the existence of unknown unknowns that hinder further improvement in BMP effectiveness and sugg

135 Progress is hindered further by the confused and sometimes contradic

136 ng a reduction in genetic variation that may hinder future adaptation for populations facing multiple

137 he position of the pinned THV leaflets would hinder future coronary access in up to 78% of patients a

138 n online chemical/metabolite databases, will hinder future discovery of bioactivities and affect the

139 personal access to information is helping or hindering health outcomes and how the perceived trustwor

140 d with lentiviral intasome biochemistry have hindered high-resolution structural studies of how INSTI

141 scess resolution and bacterial clearance are hindered in DeltafakA mutant-infected mice.

142 erial quality, directly testing this idea is hindered in part because it is not known which genes con

143 At high pressure, rotation is hindered in Phase I, such that it cannot be regarded as

144 Compromised shape control is particularly hindering in geometrically complex microenvironments, wh

145 neutralizing antibodies that can potentially hinder induction of broad neutralizing antibody response

146 and contains redundant overlapping GO terms hindering informative functional interpretations.

147 y, we demonstrate that this acid pH does not hinder initial activation of naive T-cells by dendritic

148 imal methods of PRO analysis in cancer RCTs, hindering interpretation of results.

149 of Notch1 inhibition and the obstacles that hinder its clinical application are discussed.

150 exceptional among viral vaccine antigens and hinder its immunogenicity in absolute and comparative te

151 erpotential and low Faradaic efficiency (FE) hinder its practical application.

152 reagents and steps and the high cost of PCR hinder its worldwide implementation to contain the outbr

153 d systemic instability (short half-life) has hindered its therapeutic efficacy.

154 s during the global SARS-CoV-2 pandemic have hindered its universal on demand adoption.

155 or not practise ISBCS and identify barriers hindering its implementation in the UK.

156 ous capacity loss and voltage decay, further hindering its practical application.

157 interaction with the Purkinje fibers, which hinders its clinical application as a P-gp inhibitor.

158 t for the initiation of HCMV replication but hinders its completion.

159 USP18, being stabilized by ISG15, sterically hinders JAK1 from binding to the IFNAR2 subunit of the I

160 For low-reactive or sterically hindered ketones (e.g., benzophenone, adamantanone), "Cu

161 strong influence of short-term processes may hinder long-term epidemiological forecasts.

162 First, the biological barriers that hinder mass and drug transport to the CNS are described,

163 yrosinating enzymes have remained ambiguous, hindering mechanistic study and therapeutic development.

164 rformed; this leads to arbitrary choices and hinders method development.

165 reversible, chemically modifying the RNA and hindering molecular analysis.

166 f L. camara, and this might be the reason of hindering molecular studies leading to identification of

167 t plant C allocation to an AM fungus without hindering mycorrhizal-acquired nutrient uptake.

168 atisfy the clinical need, and the challenges hindering nanomedicines delivery should be conquered for

169 r the grading of limbal stem cell deficiency hinder objective assessments of the clinical outcome of

170 e radial velocity profile which reflects the hindering of the evaporation at the rim of the droplet b

171 c factors and disturbance regimes that could hinder or promote species range shifts in response to cl

172 Asymmetry was also not apparent under hindering or assisting mechanical loads in the optical t

173 roalkene substitution and heteroaromatic and hindered ortho-substituted arenes on the azomethine ylid

174 s in the data from different experiments can hinder our ability to identify real biological variation

175 The lack of such methods has hindered our understanding of the direct correlation bet

176 s, and insect outbreaks are still uncertain, hindering our ability to accurately predict tree mortali

177 with many questions largely unexplored, thus hindering our ability to anticipate and prepare for the

178 nt of the primary productivity loss on land, hindering our understanding of the effects on global bio

179 vegetation types is poorly understood, which hinders our capacity to accurately estimate carbon turno

180 owever, the lack of subtype-specific markers hinders our understanding of the different roles of fibr

181 go undetected, undermining patient care and hindering outbreak preparedness and response.

182 ure with altered biochemical properties that hinder P. palmivora infection progress.

183 sts during experimental malaria unexpectedly hindered parasite control by impeding germinal center re

184 k showed that this rTMS on the parietal site hindered participants' ability to integrate "what" (stim

185 ppreciably slow even at 80% RH, resulting in hindered partitioning of SVOCs to large viscous particle

186 linical applications of stem cells have been hindered partly owing to a lack of standardized techniqu

187 rarchy, sometimes facilitating and sometimes hindering performance.

188 t glycans reduce spongiform degeneration and hinder plaque formation in prion disease.

189 This would hinder potential dysregulation of epigenetic control and

190 ting reports about their chemical character, hindering potential applications that could exploit the

191 High costs to the health care system may hinder PrEP expansion.

192 itional overlapping phonon modes, which have hindered previous efforts.

193 diffusion through the 8-ring in general is a hindered process, corresponding to a hopping event of th

194 s therefore poorly accessible for study, has hindered progress in mechanistic understanding.

195 ed for a bioactive attachment substrate also hinders progress.

196 eins (PVs) and other anatomic structures may hinder PV isolation.

197 tifacts, deteriorate imaging capability, and hinder quantification of fluorescent signals, thereby co

198 eral extractions with successive adjustments hindering rapid process intervention.

199 A limitation of BCIs that has hindered real-world adoption is poor long-term reliabili

200 derlie phenotypes like phantom limb pain and hinder recovery.

201 unately, the lack of analytic techniques has hindered researchers' ability to quantify the associatio

202 Rotation around the exocyclic double bond is hindered, resulting in room-temperature fluorescence.

203 iates with ribosomes and that EBP1 silencing hinders ribosomal RNA processing.

204 ically, we observe that a G545S substitution hinders rotation of the beta3 strand necessary to form t

205 is can yield highly overlapping spectra that hinder sample identification.

206 titutional diversity, unless addressed, will hinder SER's ability to address other aspects of diversi

207 nt effect prediction methods, data diversity hindered simplification and generalization.

208 Off-sample ion images confound and hinder statistical analysis, metabolite identification a

209 Coronary calcification hinders stent delivery and expansion and is associated w

210 tropomyosins are all in positions that would hinder strong myosin binding to actin.

211 shingles, but its cell-associated nature has hindered structure studies.

212 loci of the yeast genome are not available, hindering studies of DSB repair in different genomic reg

213 The major complication hindering successful subzero preservation is the formati

214 are essential to overcome current challenges hindering successful vaccine development.

215 roduction as a potential physical barrier to hinder T cell infiltration.

216 We have shown hindered terminal Schwann cell (tSC) injury response and

217 46% global) are the nucleophilic attack of a hindered tertiary alkoxide, a ring-closing metathesis re

218 be adaptive, these hard-wired reactions can hinder the ability to learn flexible "instrumental" acti

219 rognosis; however, multiple challenges still hinder the adoption of TMB as a biomarker.

220 ous electrodeposition and contact loss often hinder the application of a lithium metal anode in solid

221 llectual property and privacy control, still hinder the application of network analysis to financial

222 ex assay methods in cultured mammalian cells hinder the breadth, speed and scale of these experiments

223 labor requirements and technical limitations hinder the cell composition quantification using cell-so

224 However, various biological barriers hinder the clinical translation of oral insulin.

225 al research and practical applications still hinder the commercialization of SSLSBs.

226 ectivity, especially in a pure-water system, hinder the development of photocatalytic CO(2) RR owing

227 Aromatic hydrocarbon pool species severely hinder the diffusion and their spatial distribution in t

228 ly curved mid to anterior presacral spine to hinder the dorsal slope of the whole presacral series ca

229 ability to suppress adaptive immunity and to hinder the effectiveness of anticancer treatments.

230 iology and clinical trial design constraints hinder the enrollment of those populations at the greate

231 wells can be suitably sealed with cement to hinder the escape of CO(2).

232 ess; in fact, strikingly, awareness seems to hinder the exploitation of the relevant knowledge.

233 e variability among the class 5 adhesins may hinder the generation of cross-protective antibodies.

234 ently accurate atomic structure calculations hinder the identification of suitable transitions in HCI

235 ther polyploid crops, sequencing costs still hinder the implementation of genome-based breeding metho

236 ith higher costs and poor compliance and can hinder the implementation of global immunization campaig

237 gy disbalance and aberrant maturation likely hinder the integration of PV(+) interneurons into cortic

238 lity and durability, and high cost, thus far hinder the scalable synthesis and industrial application

239 Novel antibiotics must be used sparingly to hinder the spread of resistance, but small companies can

240 rticularly when studying biomedical data may hinder the use of classical statistical methods.

241 Moreover, depletion of ITGB3 hindered the ability of vIL-6 to promote angiogenesis.

242 ariability with gHDX measurements, which has hindered the broader adoption of gHDX for structural MS.

243 ck of consistency in methods and designs has hindered the comparability of study findings.

244 dels for hepatitis C virus (HCV) has greatly hindered the development of effective vaccines.

245 vation and G protein-coupling knowledge have hindered the development of therapeutic applications.

246 rtunately, a scarcity of molecular tools has hindered the discovery of new drug targets.

247 To date, scalability limitations have hindered the exploration and application of sequence-def

248 The loss of SKAP2 significantly hindered the K. pneumoniae-induced phosphorylation of SF

249 sful, but residual significant problems have hindered the opportunity to take full advantage of the p

250 residue in CD28 drove T cell exhaustion and hindered the persistence of CD28-based CAR-T cells and c

251 ar alone, and in the presence of emulsifier, hindered the polymorphic form IV-to-V transition.

252 Analytical limitations have hindered the study of cooking in the past, but this stud

253 e ethical hurdles of research in humans have hindered the translation of these NPs to clinical use.

254 nimals in efficiency of iAs methylation have hindered the translational potential of the laboratory s

255 ky system size and slow switching speed have hindered the widespread application of ToF technology.

256 al speciation from particulate to dissolved, hindering the ability of filtering organisms to capture

257 tional activity of the SM22alpha promoter by hindering the binding of serum response factor (SRF) to

258 faster motions have remained underexplored, hindering the development of a comprehensive model of co

259 reducing this problem, perspectives differ, hindering the development of effective solutions.

260 barrier properties during in vitro culture, hindering the development of robust assays for blood-bra

261 selective replacement of a single C-F bond, hindering the development of the enantioselective substi

262 k of source-diagnostic observations of BC is hindering the evaluation of uncertain bottom-up emission

263 able for the 3D structure prediction of RNA, hindering the standardization of comparative tests in th

264 ve proven to be really low (<0.01%), greatly hindering the study of these molecules.

265 ory T (T(reg)) cells accumulate into tumors, hindering the success of cancer immunotherapy.

266 cture of root neighborhoods remains unclear, hindering the understanding of belowground community ass

267 ucing the impact of the information gathered hindering the understanding of the mechanisms involved i

268 A major limitation hindering the widespread use of synthetic phages in medi

269 lls, suggesting that chromatin-bound cohesin hinders the advance of the replisome.

270 functional structures remains elusive, which hinders the continued development of these technologies.

271 Our limited understanding of such epistasis hinders the correct prediction of the functional contrib

272 PVA and other flexible ice-binding polymers hinders the design of more potent IRI.

273 nseparable mixture of thousands of compounds hinders the determination of structure-function relation

274 pable of mimicking human physiology severely hinders the development and clinical translation of ther

275 rt are, however, not fully understood, which hinders the development of new therapies.

276 This hinders the development of novel treatment modalities th

277 equirement for freshly isolated mitochondria hinders the feasibility of respirometry in multi-site cl

278 ithin a static framework in which the linker hinders the free rotation of the fluorophores and exclud

279 measurement in low-/middle-income countries hinders the identification of HBV-infected pregnant wome

280 rmal samples is still not resolved, and this hinders the potential clinical applications.

281 l energy, low surface charge density greatly hinders the practical applications of triboelectric nano

282 e number of compounds present in the spectra hinders the productive analysis of large MSI datasets wh

283 ermeability of the blood-brain barrier (BBB) hinders the release of tumor biomarkers.

284 and multiallelic experimental animals often hinders the use of genetically engineered mouse models (

285 ssion and high intrafamily sequence homology hinder their accurate annotation.

286 by evolving bacterial populations presumably hinder their adaptation in ways that are not fully under

287 dical sites in isomeric benzynes is known to hinder their radical reactivity.

288 r, low numbers of these cells in humans have hindered their clinical applications.

289 ver, limitations such as short half-life has hindered their usage.

290 PS externalized by apoptotic cells, thereby hindering their interaction with immune cells.

291 ts under solvent-free atmospheric conditions hinders their industrial application.

292 The congested nature of quaternary carbons hinders their preparation, most notably when stereocontr

293 ibitors has emerged as a major obstacle that hinders their utility beyond ER(+) breast cancer.

294 n understanding the biological barriers that hinder tissue-specific drug delivery and strategies to o

295 and Wnt-Frizzled (Fzd) cross-reactivity have hindered translational Wnt applications.

296 s can modulate gene expression by sterically hindering tRNA binding and inhibiting translation elonga

297 potentially impart a resistance to cancer by hindering tumor progression and metastasis.

298 ny of the acronyms used in scientific papers hinder understanding and contribute to the increasing fr

299 es the vicinal bisperoxidation of sterically hindered various substituted arylidene-9H-fluorene/aryli

300 uration step and suggest promising routes to hinder viral infections by inducing mis-assembly.