ライフサイエンスコーパス: hindrance

1 mplification steps effectively avoids steric hindrance.

2 ly interfere with JAM-A engagement by steric hindrance.

3 f kinase substrates and regulators by steric hindrance.

4 ction rules driven by ring strain and steric hindrance.

5 dissociates from the cap to overcome steric hindrance.

6 moderate to high yields depending on steric hindrance.

7 ses isomerization as a benefit rather than a hindrance.

8 raminidase enzymatic activity through steric hindrance.

9 -APOA2 antibody (Ab) due to its lower steric hindrance.

10 ion of their composition, charge, and steric hindrance.

11 ated congeners, which we attribute to steric hindrance.

12 initial antibody shape that prevents steric hindrance.

13 ty of situations where clogging represents a hindrance.

14 is combination of traits has been a historic hindrance.

15 n the polbeta active site without any steric hindrance.

16 helix (Phe-1 site), even if it causes steric hindrance.

17 nevertheless, most likely because of steric hindrance.

18 up to C5) providing no additional benefit or hindrance.

19 (i.e., imidazole and its analogs) via steric hindrance.

20 ynes, presumably due to the increased steric hindrance.

21 i-flexible loop structures, providing steric hindrance.

22 condary coordination sphere than from steric hindrance.

23 Reactions are sensitive to steric hindrance.

24 hydride approach is primarily due to steric hindrance.

25 trategies for overcoming an increased steric hindrance.

26 adsorption, protein denaturation, and steric hindrance.

27 high-energy state is not occluded by steric hindrance.

28 f pi delocalization, cage strain, and steric hindrance.

29 Deltalambdamax 13nm), possibly due to steric hindrances.

30 t effective phosphines feature remote steric hindrance, a concept that could guide future ligand desi

31 ly attenuated through introduction of steric hindrance adjacent to the ketone carbonyl.

32 rbenoids, which are less sensitive to steric hindrance, allows sterically encumbered carbon-carbon bo

33 the tryptophan binding site points to steric hindrance and an inability to retain the interactions us

34 tapled Trp peptide exhibited signs of steric hindrance and difficulty translocating.

35 t-lived interactions that derive from steric hindrance and diminished avidity with Nsp1p.

36 role of molecular structure including steric hindrance and directionality of heterocycles in determin

37 mino acid exchange G757D causes local steric hindrance and disruption of the channel complex.

38 (QBTs) with controlled variations in steric hindrance and electron activity of the substituents has

39 CeH-BTC displays low steric hindrance and electron density compared to homogeneous o

40 ed that this is a consequence of both steric hindrance and electrostatic repulsion.

41 network and diffuse through the cap without hindrance and fully displace/release the retained small

42 have demonstrated the crucial role of steric hindrance and hydrogen-bond interactions in thermal stab

43 the hydrogel interfaces with minimal steric hindrance and hydrophobic collapse.

44 act that the hydrolysis is impeded by steric hindrance and improved by sufficient polarity, in this s

45 eave the disulfide bond to weaken the steric hindrance and increase the polarity, promoting the hydro

46 and organotypic tissues, with reduced steric hindrance and no crosslinking compared with multivalent

47 of DNA-vWF interactions, to indirect steric hindrance and partial overlap of the binding sites, resp

48 ic solvents as a result of the strong steric hindrance and propensity for hydrolysis of APTES, which

49 dye uptake saturation by removing the steric hindrance and same-charge repulsion phenomena via multil

50 th boric acid and NDMA is governed by steric hindrance and that they have similar molecular dimension

51 They also experienced the least space hindrance and the fastest rate when binding to target mo

52 ich blocks HCO3(-) activation through steric hindrance and trapping of the Arg176 side chain.

53 the parent compound due to a reduced steric hindrance and/or insertion of electron-donating hydroxyl

54 metal ion radius, likely a result of steric hindrance and/or weaker binding to the larger metal ion.

55 enting protein crowding, myofilament lattice hindrance, and binding to the cytomatrix.

56 mplexation, Lewis acid/base hardness, steric hindrance, and electrostatic interactions.

57 twisted linker conformation, intramolecular hindrance, and framework rigidity.

58 ns such as electrostatic interaction, steric hindrance, and hydrogen bonding as well as HA molecular

59 has relied on decelerative asymmetric steric hindrance approaches.

60 Steric hindrance around the icosahedral 3-fold axes prevents bi

61 rated Lewis pair systems, the lack of steric hindrance around the Lewis basic fragment allows activat

62 eveals strong pai-pai interaction for steric hindrance around the metal active site to achieve strong

63 ing when in the presence of pervasive steric hindrance as is the case with the N-alkoxy-2,2,6,6-tetra

64 i) a cumulative effect resulting from steric hindrance associated with the brush block.

65 and, more importantly, alleviates the steric hindrance associated with typical imide groups.

66 ject to negative cooperativity due to steric hindrance at the dimer interface.

67 s, due to the significantly increased steric hindrance at the periphery.

68 that substrate inhibition arises from steric hindrance between Sites 1 and 2 of adjacent subunits.

69 oth a pai-pai stacking effect and the steric hindrance between substrate and catalyst.

70 tween DNA strands on the surface, (2) steric hindrance between tethered DNA probes, and (3) nonspecif

71 vature of the membrane increases, the steric hindrance between the disordered protein and membrane is

72 the N-terminal end of Aga2p to avoid steric hindrance between the fused Nanobody and the antigen.

73 teins induces their stretching due to steric hindrance between the proteins.

74 The difference in steric hindrance between Tyr/Trp(604) and the trifluoromethoxy

75 hibition of neuraminidase activity by steric hindrance, blocking access of neuraminidase to sialic ac

76 The reaction is sensitive to steric hindrance by 4- and 6'-substituents.

77 lysis and modeling of EhACK indicated steric hindrance by active site residues constricts entry to th

78 Furthermore, to reduce steric hindrance by cells, the signal probes rather than the ta

79 we observed may be due to bead saturation or hindrance by existing glycans in the matrix that preclud

80 bition is not solely mediated by active site hindrance by its antitoxin.

81 acterial strains to fucose alleviated growth hindrance by lactose and partially recovered the fluores

82 ocally slowed-down Brownian motion and local hindrance by obstacles both improve it.

83 These differences may be due to steric hindrance by the 11-keto group in CF3DODA-Me, which prev

84 in the basal membrane, suggesting diffusion hindrance by the adhesion of the cells to the substrate.

85 ain interaction with ADAMTS13 through steric hindrance by the bulky carbohydrate structure.

86 lost when it is N-glycosylated due to steric hindrance by the glycan.

87 phosphorylated state, suggesting that steric hindrance by the His-36 side chain prevents constitutive

88 The detection is based on diffusional hindrance by the insulating objects which alters the flu

89 ligible Si-Ge intermixing owing to geometric hindrance by the Si nano-tip approach.

90 grees of branching, likely due to the steric hindrance by these bulky residues.

91 how binding site complementarity and steric hindrance can tune substrate affinity.

92 this substrate-dependent behavior to steric hindrance caused by substrate-induced rumpling of the Fe

93 To compensate for increased steric hindrance, cells employ two alternative strategies.

94 mobilization of nucleic acids and for steric hindrance close to full hybridization of the surface pro

95 Steric hindrance does not affect this process.

96 onding due to T338M mutation and from steric hindrance due to the presence of an inflexible phenyl ri

97 out questionnaire regarding the symptoms and hindrances due to JCP.

98 There is a different tendency in hindrances due to pediatric JCP between in patients and

99 rs like carbocationic stability, less steric hindrance during C-C coupling, and facile dearomatizatio

100 he studied systems is associated with steric hindrance during the chemiexcitation sequence, rationali

101 of the HER2 extracellular domain, 2) steric hindrance ( e.g., MUC4 and MUC1), 3) parallel pathway ac

102 -15 containing amines having distinct steric hindrances (e.g., primary, secondary) and similar loadin

103 ea of the dye molecule increases, the steric hindrance effect exerted on the neighboring adsorbed mol

104 ectrodes leverages three effects: (1) steric hindrance effects at the nanoscale, (2) a size-dependent

105 Steric hindrance effects of polysaccharide chains on the effici

106 dG-C8-AAF in all sequences stems from steric hindrance effects of the acetyl group which significantl

107 electrochemical sensor that utilizes steric hindrance effects to signal the presence of large macrom

108 d to a signaling DNA strand generates steric hindrance effects, which limits the ability of this DNA

109 the neighboring nanoparticles due to stereo-hindrance effects.

110 m of the reactant alkenes arises from steric hindrance encountered in bond formation at the adjacent

111 of the xanthine plane because of the steric hindrance exerted by the two carbonyls.

112 ees ) in PPP-NN were observed due to smaller hindrance for a five vs a six membered ring.

113 ter and in a humid environment is a critical hindrance for applications.

114 apid response in chemical sensing is a major hindrance for further development in the field.

115 entral hydrophobic region provides the major hindrance for ion diffusion along the permeation pathway

116 ode and input/output modes has been the main hindrance for many applications.

117 Steric hindrance for naphthalene increases exponentially from 9

118 rotein activities, but also creates a steric hindrance for protecting the glycoproteins from degradat

119 vator molecule asymmetrically without steric hindrance for the binding of a second cofactor.

120 lation at Asn-163 of CD16 removes the steric hindrance for the CD16-hIgG1 Fc binding and thus increas

121 in the constriction zone that suffers steric hindrance for the reorientation needed for its onward tr

122 s during mammalian embryogenesis, is a major hindrance for the transmission of nongenetic information

123 s PSII supercomplexes from plants has been a hindrance for their deep structural and functional chara

124 However, a major hindrance for wider use of the technology is the reduced

125 indered its deposition mainly through steric hindrance forces.

126 ed nanopores without steric or electrostatic hindrance from hydrophobic or charged regions of transpo

127 is is the first time that deleterious steric hindrance from long single-stranded regions adjacent to

128 variants all converge to remove N-TR1 steric hindrance from the 806-epitope, which we show is alloste

129 e thiol-Ag chemistry and the specific steric hindrance from the organic layer of fluorescent Ag nanoc

130 drated saccharide residues as well as steric hindrance from the polymer backbone.

131 angevin motion (fLm) due to the viscoelastic hindrance from the surrounding network of proteins and c

132 Due to steric hindrance from the two relatively large labels, attachme

133 The increased steric hindrance generated by the substitution reduced the exci

134 lood-Brain Barrier (BBB), known as the major hindrance, greatly limits therapeutics penetration into

135 One possible hindrance has been the lack of immunogens that properly

136 ing new approach, the electrochemical steric hindrance hybridization assay (eSHHA) has been introduce

137 Using this steric hindrance hybridization assay in an electrochemical form

138 rt a peptide-mediated electrochemical steric hindrance hybridization assay, PeSHHA, specially for the

139 de perovskite solar cells has become a major hindrance impairing the ultimate performance and stabili

140 the 40S subunit, suggesting that mere steric hindrance impedes Listerin recruitment.

141 r to that of EC1 alone but shows that steric hindrance imposed by EC2 would likely prevent multiprote

142 A major hindrance in engineering tissues containing highly metab

143 modifications (PTMs) is a widely recognized hindrance in epigenetics research.

144 city of examples has served as a significant hindrance in furthering our understanding of this proces

145 The major hindrance in large-scale production of olive oil is oliv

146 te for another, potentially explains a major hindrance in reconstituting enzymatic activity in vitro.

147 A major hindrance in studying human meiosis has been the inabili

148 half, resulting in a reduction of the steric hindrance in the "fjord" region of the molecule, which c

149 Bub3-Bub1 molecules: low Bub1 abundance and hindrance in the binding of more than one Bub3-Bub1 mole

150 hanisms underlying fertilization have been a hindrance in the development of transmission-blocking in

151 w that 5-methylcytosine indeed causes steric hindrance in the HIF binding pocket.

152 amines, and we quantify the degree of steric hindrance in the ortho positions that is required for at

153 prodrugs; (ii) negative charges, high steric hindrance in the side chains, or a rigid diester decreas

154 dest effect on reaction rate, whereas steric hindrance in the transition state can significantly reta

155 of the configuration depending on the steric hindrance in the vicinity of the hydroxy group.

156 re state of the flow, constituting a serious hindrance in turbulence theory and even establishing reg

157 Steric hindrance in turn depends on matrix porosity, matrix def

158 ith the more crowded C2 and C3, where steric hindrance increases the interplanar separation at contac

159 The steric hindrance induced by the antibody leads to a current dec

160 fic interfacial interactions owing to steric hindrance induced by the covalent tether.

161 structure but the microscopic basis of this hindrance is not fully understood.

162 driven anti-viral immunity; however, a major hindrance is STING's cytosolic localization which requir

163 rements and simulations indicate that steric hindrance is the dominant factor responsible for motion

164 igestion was aimed at removing the molecular hindrance, made up by the heavily glycosylated egg prote

165 One hindrance may come from the adoption of the organic chem

166 However, rate-limited kinetic hindrance may explain our observations.

167 sion by CNMs is likely dominated by a steric hindrance mechanism, coupled with electrostatic repulsio

168 ents of a standard immunoassay due to steric hindrance-mediated release of prebound fluorescent repor

169 Ring size and adjacent steric hindrance modulate this hidden hydrophilicity, thus maki

170 tography-derived indices of tract volume and hindrance-modulated orientational anisotropy (HMOA).

171 Structurally, the dorsal cingulum volume and hindrance-modulated orientational anisotropy was signifi

172 The reason is that steric hindrance must be overcome to nucleate the binding compl

173 Insertion of a steric hindrance mutation in the center of TM7 (G286F in positi

174 affinity and base-CP affinity through steric hindrance; Nas6 clashes with the lid in the ATP-hydrolys

175 mical methods and that to account for steric hindrance near the reaction center, it was also necessar

176 chain conformation due to the strong steric hindrance of bulky ethylhexyl side chains.

177 Our work suggests that steric hindrance of ethereal ligands plays an important role in

178 with a few lysines inserted to overcome the hindrance of extreme insolubility and two D-lysines to l

179 f the molecule, probably resulting in steric hindrance of ficolin-1 interaction with PTX3.

180 ld serve as a simple means to prevent steric hindrance of flagellar motility or to ensure that phage-

181 These findings strongly suggest that steric hindrance of heterophilic transinteraction between Dsg a

182 by compaction of higher-order chromatin and hindrance of mRNPs from engaging nuclear pores.

183 We further showed that the steric hindrance of Mucin-4, a membrane protein, was responsibl

184 s multimodal delivery strategy minimizes the hindrance of NP diffusion imposed by the brain extracell

185 The steric hindrance of Py and FA largely dictates the HDF reaction

186 We report that steric hindrance of R1 and R2 groups of the chiral lithium amid

187 Further increase in the steric hindrance of R1 and R2 groups results in the formation o

188 n of organics) were attributed to a physical hindrance of SiO(2)-cell interactions by the SOM and enh

189 3-57.4% in adult medaka breeding pairs, with hindrance of SSC development resulting in the largest di

190 of the enzymatic activity is not a result of hindrance of substrate binding, but rather a consequence

191 est that inhibition of AMPK occurs by steric hindrance of the active site pocket and by inhibition of

192 free N2O or MesCNO despite increased steric hindrance of the adducts.

193 Owing to the steric hindrance of the axle phenyl group, the threading of the

194 The steric hindrance of the core unit exerted upon the rotors prove

195 h surface sites and play a marginal sterical hindrance of the crystal growth.

196 are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyhetero

197 The diffusional hindrance of the glycocalyx along the cell surface on ex

198 linear product is facilitated by the steric hindrance of the IPr ligand.

199 Li.S)2 was observed by increasing the steric hindrance of the ligand.

200 show that the ability to overcome the steric hindrance of the matrix cannot be attributed to a single

201 and resisting forces arising from the steric hindrance of the matrix.

202 ich was previously "protected" by the steric hindrance of the MB stem-loop structure, accessible.

203 reaction that was unsuccessful due to steric hindrance of the oxygen at the C33 position, we were abl

204 he N-terminal segment of Par17 causes steric hindrance of the Par17 active site, thus interfering wit

205 Structural and steric hindrance of the polymer backbone forces acene polymeriz

206 tic acid was observed possibly due to steric hindrance of the polymer chains in the cross-linked hydr

207 ed bulkier (NbOF5)(2-) caused the looked-for hindrance of the previously free-rotating pyrazine moiet

208 ning both the proton affinity and the steric hindrance of the probe to fully understand and map the c

209 Increase of steric hindrance of the R1 and R2 groups suppresses the formati

210 tion singles calculations suggested that the hindrance of the rotational relaxation of the S(1) state

211 However, the limited tolerance to steric hindrance of these couplings restricts the synthetic ava

212 i ions has a strong influence through steric hindrance of transverse fluoride ion vibrations, which d

213 Wip1 is a negative regulator of p53 and hindrance of Wip1 activity by novel inhibitor GSK2830371

214 g the composition of pivot groups and steric hindrances of the substituents on various linker rotamer

215 re and the physical properties (e.g., steric hindrance) of the organic shell were fully utilized for

216 uctural characteristics (amine order, steric hindrance, -OH group substitution and alkyl chain length

217 A strong effect of the steric hindrance on the absorption and emission spectra was rev

218 For DPAC and FlPAC with higher steric hindrance on the N,N'-substituents, normal Stokes-shifte

219 ons as an antiviral clamp, conferring steric hindrance on the RNA-dependent RNA polymerases of divers

220 ones, probably due to the effects of steric hindrance or electron donors at the ortho position to su

221 es can be restricted in reactivity by steric hindrance or enhanced by binding interactions with nearb

222 ransient anomalous diffusion due to obstacle hindrance or power-law-distributed residence times (cont

223 ment controls this motion - either by steric hindrances or by modulating the electronic structure of

224 One hypothesis proposes that the hindrance originates in large part from the presence of

225 ten controlled by directing groups or steric hindrance ortho to a potential reaction site.

226 nnective tissue and must overcome the steric hindrance posed by pores that are smaller than the cells

227 These data suggest that the hindrance presented by the location of a DNA lesion is d

228 of keratins, neighboring residues and steric hindrance preventing deamidation of N.

229 the unfolded region may alleviate the steric hindrance produced by the cargo protein, by functioning

230 immuno-magnetic aggregates providing steric hindrance protecting the interior binding sites from int

231 epulsion, high hydrophilicity and the steric hindrance provided by the coating that blocks bacterium-

232 anarization, DPAC and FlPAC encounter steric hindrance raised by the N,N'-disubstitutes, resulting in

233 g enzyme 2 (ACE2) receptor because of steric hindrance rather than epitope overlap.

234 I) diazoalkane complex showcases that steric hindrance represents an inherent limitation of the chose

235 by parasitic plants is a major agricultural hindrance resulting in substantial crop losses worldwide

236 oxybenzene units present considerable steric hindrance, resulting in the formation of isomers and inh

237 In order to overcome these hindrances, scientists around the globe are searching fo

238 However, this hindrance should not act as a barrier to delay intervent

239 tional methods, shedding light on its steric hindrance, sigma-donating ability, and Bronsted and Lewi

240 e of its high ring strain and reduced steric hindrance, Sph exhibited fast reaction kinetics (k2 up t

241 rbed quantity at saturation (N asat), steric hindrance (tau), concentration at half saturation (c1/2)

242 igate how cells respond to changes in steric hindrance that arise from altered cell mechanical proper

243 alizumab light chain, perhaps causing steric hindrance that disrupts viral entry.

244 that KIR binding to HLA-C must override the hindrance that His-36 puts on KIR2DL1 self-association.

245 ow that the intersection poses a significant hindrance that leads to long pauses in transport only wh

246 glycosylation at this site may remove steric hindrance that reduces EBV gH/gL binding to EphA2.

247 In line with this steric hindrance, the recombinant GH43 variants did not release

248 ndau, Verwey and Overbeek (XDLVO) and steric hindrance theories to interpret the experimental results

249 e binding pocket that imposes a clear steric hindrance thereby excluding bulkier lignin precursors.

250 inhibit NA enzymatic activity through steric hindrance, thus limiting NA access to sialic acids when

251 assembly of nascent desmosomes due to steric hindrance, thus rendering acantholysis irreversible.

252 ly excludes larger substrates through steric hindrance, thus serving as a molecular gatekeeper for su

253 by a combination of glycol coverage, steric hindrance, TiO2(110) order, and the amount of subsurface

254 larges nanopores, which helps relieve steric hindrance to adsorption.

255 and colleagues identify epitope masking as a hindrance to antibody boosting after repeated administra

256 brane itself appears not to be a significant hindrance to diffusion of Fa.

257 g dead-space microdomains, contribute to the hindrance to diffusion.

258 yrase and Topoisomerase I inhibitors suggest hindrance to escape supercoiling buildup at low temperat

259 h sides of the cell membranes form the major hindrance to Fa transfer.

260 of plant species richness and N inputs is a hindrance to forecasting the state of the soil N cycle a

261 une evasion by sequence variation is a major hindrance to HIV-1 vaccine design.

262 , suggesting that the latter is the greatest hindrance to increased precision.

263 tants conferred resistance by causing steric hindrance to inhibitor binding.

264 One hindrance to its universality is that no single protocol

265 content suggests that the decrease in steric hindrance to rupture the (3)C-O bond is the fundamental

266 has been at best misleading and at worst, a hindrance to selecting the appropriate treatment plan fo

267 Such draft genomes present a hindrance to the complete understanding of the biology a

268 One hindrance to the development of cardioprotectants is the

269 e network, as opposed to repulsion or steric hindrance to the diffusion of molecules through narrow p

270 tism has long been conjectured to be a major hindrance to the discovery of genetic risk factors, lead

271 rom known alloy parameters remains the major hindrance to the discovery of new systems.

272 , relapse and chemoresistance remain a major hindrance to the fight to minimize the burden of the dis

273 ent drug release rates resulting from steric hindrance to the formation of enzyme-substrate complex a

274 This hindrance to the study of alternative mechanisms of G pr

275 A major hindrance to the study of honey bee pathogens or the eff

276 current brain-machine interfaces is a major hindrance to their clinical translation.

277 e(-) transfer process, which poses a severe hindrance to their practical use.

278 es, and improper badge placement are a major hindrance to this goal.

279 ency in the timing of such assessments, is a hindrance to understanding its true prevalence, severity

280 othesized to be due to alterations in steric hindrance to water and urea, and/or changes in protein f

281 O, making foulant adsorption not create much hindrance to water flux.

282 reatment are burdensome to the patient and a hindrance to widespread use of PDT as standard field the

283 gion 1 (HVR1) of E2 are believed to be major hindrances to developing universally protective HCV vacc

284 re cited by only 26% of respondents as major hindrances to implementation of surveyed programs.

285 Given the substantial economic and logistic hindrances to providing ART for all people with HIV in r

286 l))) of the pyrimidines (Pyr) and the steric hindrance toward intermolecular energy transfer and intr

287 ood and drinking water is a major threat and hindrance towards ensuring food and water safety.

288 may block membrane fusion by induced steric hindrance upon primary receptor binding, thereby abrogat

289 Removal of distal pocket steric hindrance via a Leu-->Ala mutation yields favorable O(2)

290 ne metathesis of substrates with propargylic hindrance was investigated, revealing the successful com

291 Despite this increase of steric hindrance, we find that cell invasion is only marginally

292 onditions was initially attributed to steric hindrance, we found out that cyclization via the amide o

293 roxyl groups, hydrophobic bonding and steric hindrance were characterised.

294 l or hydroxyl group and have moderate steric hindrance were enzymatically transformed, likely by phos

295 ng linkers differing in the degree of steric hindrance were used in antibody conjugates to test the e

296 xpected that van der Waals forces and steric hindrance will render the motion of the larger triptycen

297 HF moiety, presumably causing greater steric hindrance with CC-chemokines.

298 alkyl side chains in order to prevent steric hindrance with neighboring hydrogens attached to core th

299 ows, upon CO binding, a reduced heme sliding hindrance, with the heme present in a peculiar double co

300 ompeting effects of base polarity and steric hindrance, without changing the average structure.