ライフサイエンスコーパス: hippocampal

1 respect to the correlation between raphe and hippocampal 5-HT(1A) binding which was more pronounced i

2 ala, thalamus, IFG and dmPFC correlated with hippocampal 5-HT(1A) binding.

3 irment in spatial learning following chronic hippocampal Abetao injections.

4 e recognition task designed to elicit strong hippocampal activation to test this prediction in human

5 ether, these findings indicate that preonset hippocampal activity does not reflect general arousal/at

6 New evidence reported by Solomon et al. that hippocampal activity tracks distance in semantic space d

7 eurons (CCK+INs) are crucial for controlling hippocampal activity.

8 y high level of similarity in prefrontal and hippocampal afferents but some differences in afferent c

9 nia, and postmortem evidence indicates lower hippocampal alpha5-GABA(A)Rs protein and mRNA levels in

10 is continuously required for the survival of hippocampal and cortical neurons in mice.

11 in primary cortical cultures, and from acute hippocampal and cortical slices from male wild-type and

12 ction potentials in cardiomyocytes, cultured hippocampal and dorsal root ganglion neurons, and brain

13 Hippocampal and fronto-temporo-parietal networks that re

14 We found that hippocampal and frontoparietal regions formed abstract r

15 TDP-43, influence non-linear trajectories of hippocampal and neocortical atrophy in Alzheimer's disea

16 anism through which verubecestat might cause hippocampal (and other brain region) volume loss by asse

17 Persistent neural activity in cortical, hippocampal, and motor networks has been described as me

18 he two-way functional significance of direct hippocampal-anterior thalamic interactions for spatial p

19 anges using PET-MRI in AD compared to global hippocampal assessment.

20 er in the fourth decade of life, followed by hippocampal atrophy and changes in cognition in the fift

21 myloid-beta and tau deposition in the brain, hippocampal atrophy and increased rates of hippocampal a

22 43 and tau are associated with early or late hippocampal atrophy in Alzheimer's disease and primary a

23 , hippocampal atrophy and increased rates of hippocampal atrophy over time.

24 c resonance imaging, but only baseline focal hippocampal atrophy predicted progression to syndromal p

25 widespread ubiquitination, and cortical and hippocampal atrophy.

26 tau and amyloid-beta have all been linked to hippocampal atrophy.

27 as worse with greater bilateral inferomedial hippocampal atrophy.

28 open questions remain regarding the role of hippocampal-based episodic memory systems.

29 ehavior and total percent DNA methylation of hippocampal Bdnf.

30 We examined neuroimaging-derived hippocampal biomarkers in subjects at clinical high risk

31 e and DHEA) that contribute to disruption of hippocampal brain development, which in turn contributes

32 n iterative whole-brain connectomics, during hippocampal CA1 downregulation.

33 The hippocampal CA1 field integrates a wide variety of subco

34 We propose a computational model of the hippocampal CA1 network, which describes the formation,

35 ronments, place fields are rapidly formed in hippocampal CA1 neurons.

36 Thus, following fear acquisition, hippocampal CA1 place cells sharpen their spatial tuning

37 n of long-term depression (LTD) induction at hippocampal CA1 synapses.

38 The hippocampal CA2/CA3 region is thought to be able to rapi

39 pression (LTD) of excitatory transmission at hippocampal CA3-CA1 synapses, as well as suppressing hyp

40 characterized the Ca(2+)/CaM sensitivity of hippocampal CaMKII variants spanning a broad range of li

41 We showed that hippocampal cells contain a diverse collection of over 7

42 er, during resting behavior, coactivation of hippocampal cells in sharp-wave/ripples represent inferr

43 affected spatial working memory performance, hippocampal cellular proliferation, or hippocampal neuro

44 ing evoked local field potentials, increased hippocampal cFos expression, and altered CA1 calcium eve

45 FA of a second corticolimbic projection, the hippocampal cingulum, was not associated with maternal u

46 d their development and integration into the hippocampal circuit.

47 substantial gap in quantitatively describing hippocampal circuits and provides useful model specifica

48 ular clues for treating hyperexcitability of hippocampal circuits associated with neuroinflammation i

49 Plasticity within hippocampal circuits is essential for memory functions.

50 c NFIA as a key transcriptional regulator of hippocampal circuits.

51 anule cell stabilization and function within hippocampal circuits.

52 The hippocampal complex (HC) is central to long-term memory

53 rted by our subsequent investigation using a hippocampal computational model, revealing increased rep

54 k for distress, in association with neonatal hippocampal connectivity and infant memory.

55 g TSD, two nights of recovery sleep restored hippocampal connectivity to baseline levels, but did not

56 rmance in a scene recognition task, impaired hippocampal connectivity to multiple prefrontal and defa

57 memory performance nor its associations with hippocampal connectivity.

58 (in opposite directions) by between-network hippocampal connectivity.

59 relationships between memory performance and hippocampal connectivity.

60 work has shown evidence both for and against hippocampal contributions to age-related improvements in

61 Further, hippocampal-cortical discoordination is prevalent in ind

62 onsolidation, including the strengthening of hippocampal-cortical networks and integration across mem

63 impaired memory consolidation mechanisms in hippocampal-cortical networks could account for spatial

64 e density modulated connectivity in distinct hippocampal-cortical networks depending on the category

65 on-neuronal form of plasticity that remodels hippocampal-cortical networks following learning and is

66 We conclude that hippocampal cultured neurons can exhibit strong changes

67 We used rat hippocampal cultures and their acute cholesterol depleti

68 en increased neuroimmune gene expression and hippocampal degeneration in alcohol use disorder (AUD) a

69 ing a Cup/Rap model, which recapitulates the hippocampal demyelination that occurs in MS patients.

70 opic, and (2) cause structural remodeling of hippocampal dendrites.

71 The hippocampal dentate gyrus (DG) is a unique brain region

72 pical controls and differentiated these into hippocampal dentate gyrus-like neurons and astrocytes.

73 nvolved in molecular alterations that govern hippocampal-dependent functions.

74 h concomitant hypercorticalism, and impaired hippocampal-dependent spatial orientation.

75 lso possible that the methods used to detect hippocampal development during middle childhood and adol

76 l effects of low maternal n-3 PUFA intake on hippocampal development in mice.

77 ll-length C terminus of p73 is essential for hippocampal development.

78 ADHD-specific intracranial volume and hippocampal differences in children and adolescents, and

79 terns of functional connectomics involved in hippocampal downregulation.

80 The ability to link hippocampal dynamics to memory-guided behaviors has been

81 o measure 3 validated in vivo pathologies of hippocampal dysfunction-focal cerebral blood volume, foc

82 new avenues of study and even therapies for hippocampal dysfunction.

83 ion, astrocytic aromatization, and decreased hippocampal E2 levels compared with FLOX mice.

84 lation on tauopathy in the entorhinal cortex-hippocampal (EC-HIPP) network, we demonstrate that hAPP

85 showed a monotonic change across conditions, hippocampal effects were specific to recall.

86 s reveal an unexpected aspect of theta-based hippocampal encoding and provide a biological mechanism

87 d whether mnemonic prediction errors promote hippocampal encoding versus retrieval states, as marked

88 2-9, adult (postnatal day 70) cerebellar and hippocampal endocannabinoids, related lipids, and mRNA w

89 We demonstrate that hippocampal ensembles encode space at a finer scale foll

90 ampal memory, synaptic plasticity, and alter hippocampal excitability when occurring during postnatal

91 static plasticity at different timescales in hippocampal excitatory neurons.

92 o prevented the ketamine-induced increase in hippocampal excitatory neurotransmission, and this effec

93 s used to monitor dentate (DG), CA3, and CA1 hippocampal extracellular glutamate levels in 2-4, 6-8,

94 rn of SCGN immunostaining in the adult human hippocampal formation (DG, CA1, CA2, CA3, subiculum, pre

95 synapses in the isocortex, olfactory areas, hippocampal formation and cortical subplate.

96 lenial and parietal cortices, as well as the hippocampal formation and striatum, provide a plethora o

97 tegorization task.SIGNIFICANCE STATEMENT The hippocampal formation and the medial prefrontal cortex o

98 The cetacean hippocampal formation has been noted to be one of the sm

99 become available.SIGNIFICANCE STATEMENT The hippocampal formation is a crucial functional substrate

100 rchitecture, and distribution of AChE in the hippocampal formation of the Atlantic white-sided dolphi

101 m the anterior thalamic nuclei to the dorsal hippocampal formation were inhibited, followed by separa

102 ructural and functional heterogeneity of the hippocampal formation, we sought to characterize the sub

103 ex produced reliable and specific effects in hippocampal function at cellular, population, and behavi

104 Computational theories of hippocampal function suggest that dentate gyrus and CA(2

105 Hippocampal function was assessed using a verbal memory

106 ould be particularly effective for impacting hippocampal function, as this stimulation rhythm should

107 f EE during adolescence for restoring normal hippocampal function.

108 ichment (EE) is a potent promoter of AHN and hippocampal function.

109 r memory abilities and disordered prefrontal-hippocampal functional connectivity.

110 c excitability and spontaneous MFR failed in hippocampal GABAergic inhibitory neurons, which remained

111 0.22), and was not significantly related to hippocampal glutamate concentration (p = 0.13).

112 otic symptoms, but is not strongly linked to hippocampal glutamate concentrations.

113 experienced ego dissolution, lower levels in hippocampal glutamate were associated with positively ex

114 flammation induced by lipopolysaccharides on hippocampal glutamatergic and GABAergic synaptic transmi

115 Preclinical models of psychosis propose that hippocampal glutamatergic neuron hyperactivity drives in

116 ced precuneus/posterior cingulate cortex and hippocampal grey matter density were significantly assoc

117 dren, habitual sleep duration was related to hippocampal head subfield volume (CA2-4/DG).

118 help determine the clinical significance of hippocampal hyperactivity throughout the pathophysiologi

119 campal subfields that can be associated with hippocampal hyperexcitability.

120 We quantified the effects of hippocampal IEDs on single-neuron activity and the impac

121 Behaviorally, the occurrence of hippocampal IEDs was accompanied by a disruption of reco

122 The induction of hippocampal IL-6 after pilocarpine SE was nearly abolish

123 ewing, MDD subjects demonstrated significant hippocampal inhibition of amygdala, basal-ganglia, thala

124 However, greater hippocampal inhibition of amygdala, thalamus, IFG and dm

125 patching recordings and in vivo stereotaxic hippocampal injection of AAV-encoded expression, we iden

126 Our results indicate that hippocampal inputs are necessary to maintain a precise c

127 e immature cognitive networks, as indexed by hippocampal integrity.

128 f awake consolidation processes by targeting hippocampal interactions with lateral occipital cortex (

129 as no significant correlation was found with hippocampal interictal spikes during waking.

130 roperties and activity dynamics of the major hippocampal interneuron classes in behaving animals.

131 Since hippocampal interneurons control information processing,

132 in a mouse model of NF1 reverts deficits in hippocampal learning.

133 In temporal lobe epilepsy cases, hippocampal levels of phosphorylated amyloid precursor p

134 oding reactivation in LOC and memory-related hippocampal-LOC functional connectivity were no longer p

135 of AMPKalpha2 isoform impairs cognition and hippocampal LTP by PERK-mediated eIF2alpha phosphorylati

136 rcise studies targeting postnatal periods of hippocampal maturation (specifically targeting periods o

137 tabilization.SIGNIFICANCE STATEMENT Studying hippocampal maturation can provide insight into episodic

138 y when occurring during postnatal periods of hippocampal maturation.

139 ively privileged in its ability to influence hippocampal memory function.

140 Together, these results demonstrate that hippocampal memory updating is impaired with aging and e

141 during the 4(th) postnatal week, can enable hippocampal memory, synaptic plasticity, and alter hippo

142 needed to fully restore memory function and hippocampal-memory associations after one night of total

143 -1beta gene expression, and visualization of hippocampal microglia revealed similar effects in vivo.

144 vious study has investigated APOE effects on hippocampal microstructure using NODDI.

145 iRNA-seq to study TBI-induced changes in rat hippocampal miRNAs up to one year post-injury.

146 ut little is known about the relationship of hippocampal morphology with memory.

147 In contrast, FXGs in hippocampal mossy fibers increased in abundance across d

148 dentified specific and delayed disruption of hippocampal-mPFC synaptic transmission and functional co

149 Our data reveal important insights into the hippocampal-neocortical dialogue, which is of key import

150 tive consolidation, comprising a neocortical-hippocampal-neocortical reactivation loop initiated by t

151 ct inhibitory synapses and its regulation of hippocampal network activity is not well understood.

152 ly distinct homeostatic responses influenced hippocampal network activity, we quantified the rate of

153 Brief volleys of TBS targeting the hippocampal network increased activity of the targeted (

154 his by targeting an accessible region of the hippocampal network via transcranial magnetic stimulatio

155 n of multiple unique environments within the hippocampal network.

156 ANCE STATEMENT Patterned network activity in hippocampal networks plays a key role in the formation a

157 to the development and construction of these hippocampal networks, and ultimately clues to their func

158 rect influence of noninvasive stimulation on hippocampal neural activity and highlight that the theta

159 rect, beneficial influence of stimulation on hippocampal neural activity related to memory and suppor

160 Similarly, greater hippocampal neurite orientation-dispersion was linked to

161 pecificity may increase our understanding of hippocampal neurobiology and associated pathologies.

162 dies specifically on the role of human adult hippocampal neurogenesis (AHN) in MDD and AD.

163 Understanding why adult hippocampal neurogenesis (AHN) is impaired in Alzheimer'

164 adult-specific deletion of Ars2 compromises hippocampal neurogenesis and results in specific behavio

165 h a majority of MS patients, we investigated hippocampal neurogenesis and structural development of a

166 myelination, providing critical insight into hippocampal neurogenesis as a potential therapeutic targ

167 Hippocampal neurogenesis plays an important role in lear

168 In addition, adult hippocampal neurogenesis was observed in both species, o

169 ich cross into the brain and stimulate adult hippocampal neurogenesis.

170 ance, hippocampal cellular proliferation, or hippocampal neurogenesis.

171 , underlies age-related alterations in adult hippocampal neurogenesis.

172 Here, we investigated, in rat hippocampal neuronal cultures derived from embryos of un

173 Studying PAT1 in mouse primary hippocampal neuronal cultures from both sexes and using

174 Primary adult murine hippocampal neuronal cultures infected with HSV-1, with

175 MARCKS stimulates neuritogenesis of primary hippocampal neurons after addition to the culture.

176 otentials in single trials from cultured rat hippocampal neurons and can be used in concert with gree

177 at the cellular level and most prominent in hippocampal neurons and cerebellar Purkinje cells.

178 iously published data from dissociated mouse hippocampal neurons and dissociated rat cortical neurons

179 f the modulation of the individual firing of hippocampal neurons by an IED predicted the extent of re

180 Fo ATP synthase function in primary cultured hippocampal neurons by using non-lethal oligomycin A tre

181 interleukin-33 (IL-33) is expressed by adult hippocampal neurons in an experience-dependent manner an

182 in the hippocampus, we recorded from single hippocampal neurons in macaque monkeys navigating a virt

183 e, a significant overexpression of A(2A)R in hippocampal neurons of aged humans, which is aggravated

184 ng, we show that knocking down GluN3A in rat hippocampal neurons promotes the inducible transcription

185 Knockdown of LASP1 in cultured rat hippocampal neurons results in a substantial reduction i

186 Our computational model of BD hippocampal neurons that was based on our measurements r

187 loss-of-function assays, we show that in rat hippocampal neurons the MPS is an actomyosin network tha

188 ging and single nanoparticle tracking in rat hippocampal neurons to unveil the nanoscale topography o

189 phorylation of endogenous Nlgn1 in CA1 mouse hippocampal neurons using a photoactivatable tyrosine ki

190 Cultured rat hippocampal neurons were treated with cerebrospinal flui

191 cute and/or latent HSV-1 infection in mature hippocampal neurons, a region of the brain severely impa

192 ng a molecular replacement approach in mouse hippocampal neurons, we show here that tamalin plays a c

193 lei of Purkinje cells, striatal neurons, and hippocampal neurons.

194 C1 or mTORC2 in cultured mouse glutamatergic hippocampal neurons.

195 spines and synaptic deficits in cultured rat hippocampal neurons.

196 lar stress-gated switch function in cultured hippocampal neurons.

197 ation in synaptic facilitation of excitatory hippocampal neurons.

198 ith 40 nm spatial resolution, on primary rat hippocampal neurons.

199 s toward the leading edge in growth cones of hippocampal neurons.

200 s synaptic plasticity in dendritic spines of hippocampal neurons.

201 nts and increases action potential firing in hippocampal neurons.

202 er widespread waves of extracellular GABA in hippocampal neuropil.

203 We found that hippocampal NLGN1 was decreased in patients with AD in c

204 Our study shows that proliferation of hippocampal NSCs and synaptic connectivity of adult-born

205 e direct access of blood-borne substances to hippocampal NSCs.

206 neurons are sparse, and local processing of hippocampal output signals within mEC LV is asymmetric,

207 synaptic efficacy, and significantly reduced hippocampal oxidative stress and neuroinflammation.

208 We investigated the impact of parenthood on hippocampal OXTR in male and female titi monkeys, a pair

209 physical abuse occurred in limbic (amygdalar-hippocampal), paralimbic (cingulo-insular and ventromedi

210 contrast MRI revealed immediate and sizable hippocampal parenchymal enhancement indicating BBB openi

211 In healthy brains, spatially tuned hippocampal place cells and entorhinal grid cells exhibi

212 t al. discover that neuronal firing rates of hippocampal place cells code for periodically repeating

213 genic mice with AD significantly dissociated hippocampal plaques.

214 pressant outcome, and that larger amounts of hippocampal plasticity may not be conducive to positive

215 However, it remains unclear what role hippocampal plasticity plays in the antidepressant respo

216 inergic and noradrenergic neuromodulation of hippocampal plasticity processes.

217 re disruptions to sharp wave ripples (SWRs), hippocampal population events with a critical role in me

218 icipants completed two tasks known to elicit hippocampal-prefrontal theta coupling: a spatial memory

219 The results were compared with hippocampal profiling from other bred rat models.

220 oderates the proliferative capacity of human hippocampal progenitors, which may subsequently impact o

221 essful inference, the mammalian brain uses a hippocampal prospective code to forecast temporally stru

222 h RBX2 knockout and Cullin 5 knockdown cause hippocampal pyramidal neuron mislocalization and develop

223 Hippocampal pyramidal neurons are characterized by a uni

224 s (AP(syn)) role in synaptic facilitation in hippocampal pyramidal neurons has been difficult due to

225 electrophysiological recordings of mouse CA1 hippocampal pyramidal neurons, AK-42 acutely and reversi

226 upon entering a context, differences between hippocampal representations of contexts (i.e., neural pa

227 se, where the great majority of experimental hippocampal research is currently performed.

228 and neocortex (NC) time-locked to individual hippocampal ripple events.

229 actions between thalamocortical spindles and hippocampal ripples.

230 d 1249 patients: temporal lobe epilepsy with hippocampal sclerosis (n = 599), temporal lobe epilepsy

231 ecially disturbances in episodic memory, and hippocampal sclerosis are common in temporal lobe epilep

232 al tumour (LEAT), vascular malformation, and hippocampal sclerosis had the best seizure outcome at 2

233 rences were most pronounced in patients with hippocampal sclerosis in the ipsilateral parahippocampal

234 r malformation, and 71.5% (2108 of 2948) for hippocampal sclerosis.

235 but less marked than those in patients with hippocampal sclerosis.

236 er, fastigial excitation robustly attenuated hippocampal seizures.

237 Research into hippocampal self-regulation abilities may help determine

238 potentiated imipramine binding and increased hippocampal serotonin level in rats.

239 ard (telencephalic) and feedback (entorhinal-hippocampal) signal propagation.SIGNIFICANCE STATEMENT P

240 tion that a global coordination mechanism of hippocampal sleep dynamics by cholinergic pontine transi

241 vo in EAE animals and ex vivo in organotypic hippocampal slice cultures.

242 Electrophysiological recordings on acute hippocampal slices showed that exogenous Amh protein add

243 Here we used mouse hippocampal slices to address how PVs signal to newborn

244 cretion by VAMP8 was also observed in murine hippocampal slices.

245 d currents in CA1 pyramidal neurons in acute hippocampal slices.

246 y over 1 week was negatively correlated with hippocampal spike frequency during sleep, whereas no sig

247 studied the correlations between interictal hippocampal spike frequency during waking and the first

248 This study investigated whether interictal hippocampal spikes during sleep would impair long-term m

249 errors may drive memory updating-by biasing hippocampal states.

250 l literature, successfully characterizes the hippocampal-striatal system as a general system for deci

251 llenge for investigators seeking to decipher hippocampal structure and function at cellular and molec

252 during childhood have been linked to altered hippocampal structure and memory performance in adulthoo

253 multaneous time-of-flight (TOF) PET/MRI with hippocampal subfield analysis of AD, mild cognitive impa

254 These hippocampal subfield changes serve to confirm and extend

255 isms suggests that the cornu ammonis 3 (CA3) hippocampal subfield supports recent, but not remote, ep

256 en's performance on a source memory task and hippocampal subfield volumes.

257 m also increased astrogliogenesis in CA1/CA2 hippocampal subfields but not in the cortex.

258 nstrated functional and molecular changes in hippocampal subfields that can be associated with hippoc

259 ng leads to dissociable coding strategies in hippocampal subfields, in line with computational theori

260 ge for indirectly related memory elements in hippocampal subfields.

261 ked by distinct network connectivity between hippocampal subfields.

262 endritic spine maturation in the ventral CA1 hippocampal subregion.

263 We analyzed hippocampal surface shapes on high-resolution magnetic r

264 e, spindles were phase-coupled with DWs, and hippocampal SWR-cortical DW coupling was strengthened in

265 ynaptic vesicle exocytosis at cultured mouse hippocampal synapses, we induced single action potential

266 e glycoprotein 2A (SV2A), were used to study hippocampal synaptic integrity in vivo in an equal numbe

267 The discovery of impaired hippocampal synaptic plasticity in the heterozygous mous

268 However, hippocampal synaptic plasticity, learning, and memory ar

269 DARs have both previously been implicated in hippocampal synaptic plasticity.

270 "pacemaker" timing signal is imposed on the hippocampal system, or it may assist in organizing targe

271 ep brain stimulation (DBS) of the entorhinal-hippocampal system, the brain's major memory hub, has be

272 or, intestinal SAA1 and SAA2 production, and hippocampal Th17 cell accumulation.

273 , recordings from humans have indicated that hippocampal theta oscillations are lower in frequency an

274 Finally, we demonstrate that hippocampal theta phase modulates parahippocampal gamma

275 Hippocampal theta thus supports learning through two int

276 To characterize human hippocampal theta, we examine the properties of theta os

277 Further, RNA-Seq data from APP/PS1 hippocampal tissue revealed that ChS significantly chang

278 KDM5A also resulted in dysregulation of the hippocampal transcriptome.

279 as demonstrated that selective modulation of hippocampal transmission by systemic administration of a

280 LAN was associated with reduced hippocampal vascular endothelial growth factor-A (VEGF-A

281 of-flight angiography we manually classified hippocampal vascularization patterns in older adults wit

282 ry afferent pathways, we showed that ventral hippocampal (vHipp) input alone enhances palatability up

283 .35 to -0.02 cm2; P = .05), 0.10-cm3 smaller hippocampal volume (95% CI, -0.17 to -0.03 cm3; P = .006

284 (PET), (18)F-flortaucipir PET, and adjusted hippocampal volume (aHCV).

285 dictive value for long-term memory function, hippocampal volume and training benefit across the human

286 Right hippocampal volume deficit and inferior temporal cortex

287 ation did not explain heterogeneity of total hippocampal volume effect sizes.

288 receptor (A(2A)R) encoding gene-ADORA2A, and hippocampal volume in AD patients was recently described

289 ults extend neuroimaging findings of smaller hippocampal volume in schizophrenia patients and further

290 However, whole hippocampal volume in the patients decreased by 0.6% aft

291 Reduced hippocampal volume is a consistent finding in neuroimagi

292 Hippocampal volume loss was attenuated (-27%) at 12 mont

293 matter hyperintensity (WMH) grade, brain and hippocampal volume, and sulcal and ventricle atrophy usi

294 ith brain disorders characterized by reduced hippocampal volume, including Alzheimer's disease (AD) a

295 lysis on each subfield, co-varying for whole hippocampal volume.

296 Previous work has suggested that posterior hippocampal volumes in depressed patients may be associa

297 ease, but it is also associated with reduced hippocampal volumes, age-related cognitive decline and p

298 DHD compared with those with OCD had smaller hippocampal volumes, possibly influenced by IQ.

299 alteration, but not through the amygdala and hippocampal volumes.

300 ariate approaches (averaging activity across hippocampal voxels), which may not be sensitive to nuanc