ライフサイエンスコーパス: histamine

1 la neurons responded to itch stimuli such as histamine.

2 talysing the decarboxylation of histidine to histamine.

3 samples spiked with known concentrations of histamine.

4 chemical methods for real-time monitoring of histamine.

5 ey interactions similar to those attained by histamine.

6 t-scan cyclic voltammetry (FSCV) methods for histamine.

7 d for contractile responses to carbachol and histamine.

8 labeling for CD63, CD203c, and intracellular histamine.

9 greater interaction with eNOS in response to histamine.

10 s responded to fungal antigens by release of histamine.

11 S spectra with characteristic Raman bands of histamine.

12 cating a potential antitumorigenic effect of histamine.

13 monstrated appearance of CD63 and release of histamine.

14 developed for the instantaneous detection of histamine.

15 ndothelial cells primed with LPS followed by histamine.

16 ontained significantly lower basal stores of histamine.

17 L-5 or IL-17A, also increased the potency of histamine.

18 activate RhoA-for instance, Galphaq-coupled Histamine 1 Receptor signaling via Galphaq-dependent act

19 Use of PPIs and histamine 2-receptor antagonists (H2RA) during the year

20 release of inflammatory mediators, including histamine(2).

21 -modifying therapies for multiple sclerosis, histamine-2 (H2) blockers, and tumor necrosis factor (TN

22 reases large cholangiocyte proliferation via histamine-2 receptor (H2HR), which is increased in patie

23 mpairment among PPI reports when compared to histamine-2 receptor antagonist control group.

24 erotonin reuptake inhibitors, tegaserod, and histamine-2 receptor antagonists have benefit as either

25 ffectiveness include proton pump inhibitors, histamine-2 receptor antagonists, prokinetics, and centr

26 Proton pump inhibitors (PPIs) or histamine-2 receptor blockers (H2RBs) are often prescrib

27 ylaxis with use of proton pump inhibitors vs histamine-2 receptor blockers resulted in hospital morta

28 urrently on therapy (55.2% on PPIs, 24.3% on histamine-2 receptor blockers, and 24.4% on antacids).

29 The histamine 3 receptor (H3R) is a presynaptic receptor, wh

30 ntagonist/inverse agonist of the presynaptic histamine 3 receptor.

31 ules expressed on TH2 lymphocytes, PDE4, the histamine 4 receptor, and Janus kinase) or specifically

32 eased the release of the mast cell mediators histamine (9.0-fold), cysteinyl leukotrienes (4.5-fold),

33 taneous anaphylaxis or direct challenge with histamine, a major granule component.

34 red RNA aptamer that specifically recognizes histamine (A1-949 aptamer), we developed an aptasensor b

35 n of corticostriatal afferents revealed that histamine, acting at H(3) receptors, negatively modulate

36 Together, these results show that histamine acutely modulates developing striatal neurons

37 udy also suggested similar closure rate with histamine administration to the forearms of human volunt

38 Here, we investigated how histamine affects developing corticostriatal circuits, b

39 Na(V)1.8(-/-) impaired histamine and 5-HT-induced scratching while Na(V)1.9 was

40 Histamine and ATP also promoted robust NO formation and

41 olished by the combination of antagonists of histamine and cysteinyl leukotrienes in the presence of

42 mast cells, resulting in reduced release of histamine and cytokines.

43 er plays a central role in the regulation of histamine and dopamine in various tissues through conden

44 However, neutrophil-derived histamine and Eosinophil Cationin Protein production and

45 Elevated concentrations of urinary histamine and its metabolite, methylimidazole acetic aci

46 Histamine and leptin levels were measured by enzyme immu

47 on of systemic anaphylaxis mediators such as histamine and mast cell protease-1 (MCPT-1) in the micro

48 (+) neurons are a direct neuronal target for histamine and Mrgpr agonists.

49 In vivo and in vitro histamine and platelet-activating factor administration

50 ated whether inflammatory molecules, such as histamine and proteases, activate prostaglandin-endopero

51 abolite, methylimidazole acetic acid, plasma histamine and serum tryptase have been reported, consist

52 trains that converted dietary histidine into histamine and shaped colonic motility; a prolific produc

53 on and osteoclast differentiation induced by histamine and Th17 cytokines.

54 has been reported in allergic rhinitis, with histamine and type-2 inflammation being responsible for

55 ontain higher levels of serotonin, dopamine, histamine and tyramine than pulps.

56 odulates several neurotransmitters including histamine and various essential physiological processes,

57 epinephrine, norepinephrine, serotonin, and histamine) and preventing sedimentation by encapsulating

58 ccessfully rejected signals from pH changes, histamine, and H(2)O(2).

59 es) and mediator content (including heparin, histamine, and neutral proteases), test cells are though

60 urotransmitters such as serotonin, dopamine, histamine, and noradrenaline have important and varied p

61 sociated with significant increases in PGE2, histamine, and tryptase in the colonic mucosa.

62 yptamine (9-fold), others (2.4-4.2-fold) and histamine appeared.

63 Tyramine and histamine are the biogenic amines (BA) most commonly fou

64 tch because of the traditional prominence of histamine as a pruritogen.

65 stness, high specificity and selectivity for histamine as a target.

66 the three Brevibacterium strains can utilize histamine as the sole carbon source.

67 Histamine as well as nasal secretions of AR but not idio

68 For FSCV detection of histamine at carbon-fiber microelectrodes, histamine oxi

69 enable the detection of dimethyl sulfide and histamine at limits of 0.5 and 0.035 mug/mL, respectivel

70 centered around the canonical IgE-mast cell-histamine axis.

71 ently of the IgE-Fc epsilon RI (FcepsilonRI)-histamine axis.

72 Displacement of the quencher strand upon histamine binding results in an increased fluorescence.

73 In this work, we sought to identify histamine-binding aptamers that could then be exploited

74 Histamine binds to one of the four G-protein-coupled rec

75 The measured concentrations can degrade histamine, but DAO activity is compromised compared to p

76 small-molecule nucleophiles methylamine and histamine, but when Spy0125 was mechanically unfolded an

77 Culture of cells in 5% O2 (>5 d) decreased histamine- but not shear stress-stimulated endothelial (

78 For histamine, cadaverine and putrescine, the removal percen

79 reatment with IL-13 increased the potency of histamine, carbachol, and leukotriene D(4) as contractil

80 s prior to injection of various pruritogens (histamine, chloroquine, or endothelin-1) and recorded sp

81 The histamine concentration and the biogenic amine index inc

82 In histamine concentration range 0-200mgkg(-1), significant

83 As it is still impossible to determine histamine concentrations in vivo, a nasointestinal cathe

84 Plasma DAO, tryptase, and histamine concentrations of four severe anaphylaxis even

85 Immunohistochemistry for histamine-containing axons reveals striatal histaminergi

86 Finally, histamine content in spoiled fish samples was measured,

87 taining 7 ng of Phl p 5 major allergen) or a histamine control.

88 an analytical range between 5 and 200 nM of histamine, corresponding to physiologically normal condi

89 Thus, histamine couples lineage-specific physiological demands

90 Nevertheless, histamine deficiency leads to behavioral alterations pro

91 O inhibition is essential to inhibit further histamine degradation after blood withdrawal.

92 histamine, possibly encoded by the putative histamine degradation pathway, highlights the importance

93 The histamine degradation rate of DAO in plasma from mastocy

94 The histamine degradation rates were measured in anaphylaxis

95 presence of a putative metabolic pathway for histamine degradation.

96 was associated with increased expression of histamine degrading enzymes and reduced histamine recept

97 ne receptor expression and the expression of histamine degrading enzymes.

98 ol or baclofen are antipruritic against both histamine-dependent and -independent pruritogens, but th

99 ell, Chen et al. (2017) delineate an elegant histamine-dependent feedback mechanism through which mye

100 and biologically characterized Py-5-labeled histamine derivatives.

101 t of rapid, facile, and sensitive assays for histamine detection suitable for point-of-need analysis.

102 ctrochemical methods have been developed for histamine detection, the mechanism of its redox reaction

103 elopment of a rapid and sensitive method for histamine determination in fish based on Surface Enhance

104 stimulated a limited number of cytokines and histamine did not stimulate the release of any cytokines

105 . reuteri mutant that was unable to generate histamine did not suppress carcinogenesis, indicating a

106 In most of the analyzed genotypes, tyramine, histamine, dopamine, serotonin, spermidine, and spermine

107 , FcepsilonR1-mediated MC degranulation, and histamine-driven effector functions preferentially in ma

108 ssociated with elevated levels of intestinal histamine due to chronic immune activation.

109 neurodevelopmental disorders resulting from histamine dysregulation.SIGNIFICANCE STATEMENT Monogenic

110 l growth and differentiation, partly through histamine engagement of H(1)R and H(4)R.

111 Furthermore, histamine enhanced the signal transducer and activator o

112 was unaffected by PGE2, but PGE2 attenuated histamine-evoked IP3 accumulation.

113 Munc13-4 promotes histamine-evoked WPB exocytosis and is present on WPBs,

114 WPB and to serve as a novel factor promoting histamine-evoked WPB exocytosis and VWF secretion.

115 Pase-activating proteins (RabGAPs) inhibited histamine-evoked, Ca(2+)-dependent WPB exocytosis, presu

116 Here we show that histamine evokes the release of the proinflammatory liga

117 oping corticostriatal synapses and show that histamine facilitates NMDA receptor-dependent LTP via H(

118 to revert into quiescence in the absence of histamine feedback, leading to their depletion, while an

119 , H and F components, threshold tracking and histamine flare and itch response and neuropathological

120 Histamine formation in fermented foods can cause histami

121 In vitro studies showed IL-24 to release histamine from human mast cells sensitized with purified

122 ccompanied with increased mRNA expression of histamine H(1) and cysteinyl leukotriene CysLT(1) recept

123 this, binding rate constants for a series of histamine H(1) receptor (H(1)R) antagonists were determi

124 tadine (2) have a long residence time at the histamine H(1) receptor (H(1)R).

125 which display potent affinity for the human histamine H(1) receptor and improved metabolic stability

126 alpha(1), dopamine D(2), serotonin 5-HT(2A), histamine H(1), and muscarinic M(1) receptors, and favor

127 Currently employed histamine H(2) receptor (H(2)R) radioligands possess sev

128 )H]UR-KAT479 ([(3)H]23), a subtype selective histamine H(2) receptor G protein-biased agonist.

129 ely characterized fluorescent probes for the histamine H(3) receptor (H(3)R) and especially for the H

130 Despite the high diversity of histamine H(3) receptor (H(3)R) antagonist/inverse agoni

131 timizations guided by in vitro affinity at a histamine H(3) receptor (H(3)R), physicochemical propert

132 gy based on targeting complexes of D(1)R and histamine H(3) receptors (H(3)R).

133 d dose with and without co-administration of histamine H1 receptor antagonist, cetirizine, and cystei

134 Histamine H1 receptor antagonists (antihistamines) are r

135 The human histamine H3 receptor (hH3R) is subject to extensive gen

136 ficacy and safety of pitolisant, a selective histamine H3 receptor antagonist with wake-promoting eff

137 e such circuit is the posterior hypothalamic histamine (HA) system, implicated in supporting wakefuln

138 Histamine (HA), a wake-promoting monoamine implicated in

139 One neurotransmitter, histamine (HA), has been well studied in both vertebrate

140 In regions with high basal permeability, histamine had no obvious effect.

141 ction in the synthesis of the neuromodulator histamine has been associated with Tourette's syndrome a

142 Histamine has pleiotropic pathophysiological effects, bu

143 from the first postnatal week onwards, with histamine having diverse effects on their electrical pro

144 The HDC/histamine/histamine receptor axis, ductular reaction, an

145 ial strains can also express HDC and secrete histamine; however, the influence of bacterial-derived h

146 Histamine, IL-17, and IL-22 stimulated RANKL expression

147 blood (PB) CD14+ monocytes were treated with histamine, IL-17, IL-21 and IL-22, and a H4R antagonist

148 of CD63 and CD203c as well as the release of histamine, IL-4 and IL-13.

149 Histamine, IL-6, IL-17, IL-21 and IL-22 induced the expr

150 nsor on human intestinal liquids spiked with histamine in a testing setup that mimics the environment

151 based competitive assay for the detection of histamine in both buffer and synthetic urine, achieving

152 rified the roles of HDC-expressing cells and histamine in heart failure post-MI using HDC-EGFP transg

153 d degranulation and release of cytokines and histamine in response to allergen.

154 The concentration of histamine in synovial fluid (SF) and sera in patients wi

155 designed for measuring the concentration of histamine in the human duodenum.

156 The importance of histamine in various physiological functions and its inv

157 ting a significant role of the cometabolite, histamine, in suppression of chronic intestinal inflamma

158 Inflammatory mediators, such as thrombin and histamine, increase intracellular calcium levels.

159 We found that acute itch stimuli, such as histamine, induced anxiety-like behavior and increased a

160 IL-4- and histamine-induced ABL1 activation in human VE cells and

161 k, which was associated with protection from histamine-induced barrier dysfunction in vitro following

162 IL-4, but not IL-5 and IL-17A, enhanced the histamine-induced Ca(2+) mobilization that was accompani

163 uctance on TV membranes that is required for histamine-induced Ca(2+) release from TV stores.

164 We show that absinthin reduces cytosolic histamine-induced Ca(2+) rises and simultaneously increa

165 s does not induce Ca(2+) signals but reduces histamine-induced cytosolic Ca(2+) increases.

166 endent mast cell cytokine production, and 2) histamine-induced endothelial permeability.

167 1(-/-) male mice were largely protected from histamine-induced hypovolemic shock, which was associate

168 ed non-histaminergic itch, without impairing histamine-induced itch.

169 male mice reduces capsaicin-induced pain and histamine-induced itch.

170 ed p38 activation depended on TAB1-TAB3, but histamine-induced p38 activation required TAB1-TAB2.

171 wing histamine treatment and is required for histamine-induced permeability.

172 model where it exhibited robust reversal of histamine-induced scratching bouts in mice.

173 temperature, most likely due to accelerated histamine-induced vasodilation.

174 A concentration of histamine inducing a 20% decline in FEV1 (PC20 ) </=16 m

175 Itch sensation to histamine injection was lost in most symptomatic patient

176 Histamine injections resulted in light-like phase delays

177 Histamine intolerance is thought to trigger manifold cli

178 the results between patients with suspected histamine intolerance, food allergy and healthy controls

179 the study was to investigate the presence of histamine intolerance, to therefore establish day profil

180 tamine parameters in patients with suspected histamine intolerance.

181 mptoms and strongly suggests the presence of histamine intolerance.

182 histamine levels in a subgroup of suspected histamine-intolerants.

183 amine formation in fermented foods can cause histamine intoxication.

184 Histamine is a key immunoregulatory mediator and can dam

185 Here we show that histamine is an active neuromodulator during the earlies

186 Histamine is an important immunomodulator influencing bo

187 herefore, accurate and facile measurement of histamine is of practical importance.

188 biogenic markers, i.e., dimethyl sulfide and histamine, is developed to monitor the spoilage of raw m

189 100 protein, tumor necrosis factor-alpha and histamine, (Kolofort) under outpatient conditions in pat

190 uinea pig airways challenged by noninjurious histamine-leukotriene-type autacoids also respond throug

191 , CRF(2)(-/-) mice exhibited increased serum histamine levels and colonic permeability after acute re

192 ance, to therefore establish day profiles of histamine levels and DAO activities, and to compare the

193 ce, CRF(2)(-/-) mice exhibited greater serum histamine levels and exacerbated IgE-mediated anaphylaxi

194 at genetic or environmental perturbations of histamine levels can impact striatal development.

195 ased DAO activities correlated with elevated histamine levels in a subgroup of suspected histamine-in

196 mptom scores, core body temperatures, plasma histamine levels, basophil numbers, antigen-specific IgE

197 gens (C48/80, endothelin, 5-HT, chloroquine, histamine, lysophosphatidic acid, trypsin, SLIGRL, beta-

198 For accurate histamine measurements during anaphylaxis, DAO inhibitio

199 Further, histamine-mediated hypothermia and regulation of endothe

200 luated as ligands of 34 serotonin, dopamine, histamine, melatonin, acetylcholine, and adrenergic rece

201 o normal mice observing the well-established histamine model of acute itch in demonstrator mice.

202 The number of histamine neurons that surround the dopaminergic neurons

203 ciated with a defect in the recycling of the histamine neurotransmitter.

204 the suppressive effect of bacterial-derived histamine on BAL inflammation was lost in HDC-deficient

205 t fibroblasts, and the inhibitive effects of histamine on fibroblast proliferation could be blocked b

206 Last, we investigated effects of histamine on longer-term changes at developing corticost

207 investigate the effect of bacterial-derived histamine on lung inflammatory responses.

208 however, the influence of bacterial-derived histamine on the host immune responses distant to the gu

209 Histamine, one of the most important biogenic amines (BA

210 on of novel imidazole alkaloids derived from histamine or histidinol and generally investigating the

211 omote adipose beiging through the release of histamine or other products.

212 d in physiologic (5%) O2 and stimulated with histamine or shear stress.

213 Here, we studied the mechanism of histamine oxidation at carbon electrodes and used that m

214 tron spectroscopy (XPS), we demonstrate that histamine oxidation requires a potential of at least +1.

215 f histamine at carbon-fiber microelectrodes, histamine oxidation was adsorption-controlled, and the a

216 Knowing the mechanism of histamine oxidation will facilitate design of better ele

217 duct adsorbed on the electrode surface after histamine oxidation.

218 etween subjective complaints and serological histamine parameters in patients with suspected histamin

219 Crucially, we show that histamine permits NMDA receptor-dependent corticostriata

220 administration of colon biopsy supernatants, histamine, PGE2, a small interfering RNA against EP2, or

221 eletion or TWEAK-blocking antibody prevented histamine/platelet-activating factor-induced vascular su

222 Histamine plays an important role in neuromodulation and

223 The capability to utilize histamine, possibly encoded by the putative histamine de

224 Histamine produced by bacteria through decarboxylation o

225 MATERIALS AND We analyzed ECP and histamine production in response to LPS by ELISA.

226 a functional link between immunomodulation, histamine production, and folate metabolism, the central

227 oxylase (HDC) is the main enzyme involved in histamine production.

228 or agonists adenosine triphosphate (ATP) and histamine promoted rapid increases in eNOS phosphorylati

229 multiple GPCRs agonists, including thrombin, histamine, prostaglandin E(2), and ADP, stimulated robus

230 Based on the results, histamine, putrescine and cadaverine were selected as in

231 Histidine decarboxylase (HDC) and histamine receptor (HR) expression were detected by qPCR

232 ed by platelet-activating factor receptor or histamine receptor 1 blockade.

233 proinflammatory responses via activation of histamine receptor 2 (H2 R).

234 In histamine receptor 2 (H2R)-deficient mice, administratio

235 These effects are influenced by host histamine receptor expression and the expression of hist

236 n of histamine degrading enzymes and reduced histamine receptor expression.

237 selected NE genes (adrenomedullin 2 [ADM2], histamine receptor H1 [HRH1], neuron-specific enolase [N

238 lated molecules including MrgprA3, MrgprC11, histamine receptor H1, IL-31 receptor, 5-hydroxytryptami

239 Pretreatment with histamine receptor-1 antagonist, azelastine prevented th

240 fusion demonstrates expression of functional histamine receptors from the first postnatal week onward

241 ichment of nine Mrgpr family members and two histamine receptors in MrgprA3(+) neurons, suggesting th

242 R shows transcripts for H(1), H(2), and H(3) histamine receptors in striatum from the first postnatal

243 ch physically interacts with macrophages via histamine receptors, exhibits substantially diminished b

244 ition of glutamate, GABA, acetylcholine, and histamine receptors, suggesting cell-autonomous mechanis

245 Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mous

246 Histamine release (HR) was tested for time-of-day- or di

247 utyrate treatment inhibited allergen-induced histamine release and airway contraction in guinea pig P

248 Ex vivo, mast cell-mediated histamine release and degranulation was augmented upon T

249 basophil activation test (BAT) and basophil histamine release assay (BHRA).

250 ify absorbed Ara h 2 and 6, and the basophil histamine release assay and the human passive cutaneous

251 and CNX-774) on IgE-dependent activation and histamine release in blood basophils obtained from aller

252 onfirmed by demonstrating that IgE-dependent histamine release in ex vivo blood basophils is largely

253 drugs are potent inhibitors of IgE-dependent histamine release in human basophils.

254 hrine stimulated mast cell degranulation and histamine release in vitro.

255 ntal algorithm for classifying the nature of histamine release induced by serum from 3 classes of sub

256 were incubated with participants' serum and histamine release was quantified as HR.

257 ated allergen-driven basophil activation and histamine release.

258 in E (IgE)-mediated mast cell activation and histamine release.

259 tyrosine kinase, induction of cytokines, and histamine release.

260 ergen presentation, basophil activation, and histamine release.

261 I, Ando et al. provide a causal link between histamine-releasing factor (HRF) interactions with IgE a

262 The CQ and histamine responses were not influenced by removal of TR

263 Optogenetic activation of histamine-responsive amygdala neurons affected both scra

264 Selective optogenetic activation of histamine-responsive amygdala neurons in adult male and

265 Electrophysiological characterization of histamine-responsive amygdala neurons showed that this p

266 , stimulation with the proinflammatory agent histamine results in a transient increase in paracellula

267 r manifold clinical symptoms after ingesting histamine-rich food due to reduced activity of diamine o

268 gy of these neurodevelopmental disorders and histamine's role in the development of corticostriatal c

269 or 2 (H2R)-deficient mice, administration of histamine-secreting bacteria also reduced inflammatory c

270 Histamine secretion from bacteria within the gut can hav

271 ions in vivo, a nasointestinal catheter with histamine-sensing capabilities has the potential to beco

272 ion of prestored MC granule mediators (e.g., histamine, serotonin, and proteases) and reduced mediato

273 ls was distinct in both released substances (histamine, serotonin, and tryptase) and the pattern of a

274 mast cell (MC) activation, biliary H2HR, and histamine serum levels were studied.

275 The synergistic cytotoxicity of tyramine and histamine should be taken into account when establishing

276 otein and Ca(2+) signals to couple on-demand histamine signals to selective WPB trafficking.

277 Moreover, thrombin- and histamine-stimulated interleukin-6 production required b

278 Indeed, in EA.hy926 cells, thrombin- and histamine-stimulated p38 activation depended on TAB1-TAB

279 Upon continued histamine stimulation, Rab46 senses localized elevations

280 ed a biphasic increase of RhoA activity upon histamine stimulation.

281 fic monoclonal antibody TF2 (anti-CEA x anti-histamine-succinyl-glycine [HSG]) and the di-HSG-DOTA pe

282 ter injection of 150 MBq of (68)Ga-IMP288, a histamine-succinyl-glycine peptide given after initial t

283 ngs of striatal spiny projection neurons and histamine superfusion demonstrates expression of functio

284 nonsense mutation in the coding gene for the histamine-synthesizing enzyme has been associated with T

285 tolisant is a first-in-class agent utilizing histamine to improve wakefulness by acting as an antagon

286 Addition of histamine to the ZnO@PLP and ZnO@Py solution resulted se

287 of E coli BL21_HTW, which is able to secrete histamine, to wild-type mice reduced lung eosinophilia a

288 cells, MALT1 protease is activated following histamine treatment and is required for histamine-induce

289 and release Eosinophil Cationic Protein and histamine, two important inflammatory mediators previous

290 We propose that histamine undergoes one-electron oxidation on an imidazo

291 wed that acute itch induced by serotonin and histamine was attenuated in Trpc4-knockout mice and ML20

292 SF and serum concentration of histamine was higher in RA, compared with osteoarthritis

293 was assessed by flow cytometry; HR-released histamine was quantified by a glass fiber-based fluorome

294 e high binding affinity of the H2 aptamer to histamine was validated using four independent assays (

295 The response to CQ, but not histamine, was largely absent in mrgpr-cluster Delta(-/-

296 eutrophil TEM when additionally treated with histamine, whereas the effects on neutrophil TEM of the

297 We conclude that a compound, in this case histamine (which has a short primary effect on vascular

298 anatomical proximity to MB-HSCs and produce histamine, which activates the H2 receptor on MB-HSCs to

299 Extraction of histamine with 0.4M perchloric acid and purification wit

300 bility of detection and spectral analysis of histamine with SERS.